Hands-on proposals for medical counseling and verbalizations to use for women with endometriosis

Hands-on proposals for medical counseling and verbalizations to use for women with endometriosis By Nasuhi Engin Aydin

An overview has been published recently in the Archives of Gynecology and Obstetrics on patient–doctor communication and psychological counseling in endometriosis by two academicians, Drs. Wischmann and  Ditzen, from Heidelberg University, Germany. There is no known cure for endometriosis and primary management…

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Can We Reliably Measure Sleep Quality in Women With Endometriosis?

Can We Reliably Measure Sleep Quality in Women With Endometriosis? By Özge Özkaya

The Insomnia Severity Index (ISI) and the Pittsburgh Sleep Quality Index (PSQI) lead to consistent scores comparable in women with deep infiltrating endometriosis, according to a new study published in the scientific journal Sleep Medicine. However, the cutoff values of…

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Are women with endometriosis more prone to have mental health disorders?

Are women with endometriosis more prone to have mental health disorders? By Hale Goksever Celik

Endometriosis is a long-term morbidity resulting in impaired physical, sexual, psychological, and social health. The most common clinical findings of endometriosis patients are chronic pelvic pain and fertility problems, associated with impaired quality of life. These women are also affected…

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Clinical awareness for endometriosis in infertility should be surged

Clinical awareness for endometriosis in infertility should be surged By Nasuhi Engin Aydin

A team of researchers from multiple centers including Stanford University and Swiss Federal Laboratories, led by Dr.Camran Nezhat have published their cross-sectional retrospective study on endometriosis and unexplained infertility association. This research paper appeared in a recent issue of the Journal…

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Fertility outcomes after discoid excision for colorectal endometriosis.

Fertility outcomes after discoid excision for colorectal endometriosis. By Selma Oransay

Colorectal endometriosis is one of the most severe forms of deep endometriosis, composing 85% of all bowel lesions. Radical treatment is segmental resection of the bowels, which can cause postoperative severe complications such as rectovaginal fistula and voiding dysfunctions that negatively…

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Vitamin D Levels Associated With Endometriosis Risk

Vitamin D Levels Associated With Endometriosis Risk By Özge Özkaya

Endometriosis is inversely correlated with the levels of 25-hydroxyvitamin D3 in the serum, according to a new study published in the scientific journal PLoS One. However, more research is necessary to establish a causal link between the disease and vitamin…

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Management of uterine adenomyomas with percutaneous cryoablation.

Management of uterine adenomyomas with percutaneous cryoablation. By Selma Oransay

Adenomyosis can negatively affect the quality of life by causing abnormal bleeding, pelvic pain, dysmenorrhea, and dyspareunia. It is often associated with endometriomas and/or leiomyomas. Treatment of the disease differs as conservative or radical, as well as pharmacological or surgical. For…

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Current status of non-invasive biomarkers for endometriosis

Current status of non-invasive biomarkers for endometriosis By Eylül GÜN

Laparoscopy has been the gold standard for the diagnosis of endometriosis, however, the understanding of how many people have the condition is limited because not everyone undergoes surgery. The different treatment modalities for patients with unexplained infertility and the invasiveness…

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Endometriosis vs. adenomyosis : is there a common pathogenesis ?

Endometriosis vs. adenomyosis : is there a common pathogenesis ? By Nasuhi Engin Aydin

This is a collaborative review on the pathophysiology of adenomyosis and endometriosis by academicians of the University of Leicester, UK; Fudan University, Shanghai, China and Sapienza University of Rome, Italy, published in a recent issue of “Biomolecules”. The pathophysiology of…

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Spontaneous Conception After Deep Endometriosis Surgery

Spontaneous Conception After Deep Endometriosis Surgery By Selma Oransay

Deep endometriosis is a severe form of endometriosis where lesions invade deeper than 5 mm into subperitoneal space. Surgical management of the disease is a challenging task requiring a multi-disciplinary approach and significant expertise in the field. Anastomotic leaks, fistula,…

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Exploring the role of thyroid function in endometriosis and polycystic ovary syndrome

Exploring the role of thyroid function in endometriosis and polycystic ovary syndrome By Eylül GÜN

Endometriosis, polycystic ovary syndrome (PCOS), and thyroid disorders are prevalent among women of reproductive age, yet their exact impacts on reproductive health and underlying mechanisms remain unclear. Given the close association of these conditions through the endocrine system, Kirkegaard et…

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Is post-cesarean pain perception and analgesic use in endometriosis-affected women different?

Is post-cesarean pain perception and analgesic use in endometriosis-affected women different? By Hale Goksever Celik

It has been known that endometriosis patients have increased pain sensitivity and different reactions to pain compared to women having no endometriosis. Several mechanisms such as nociception, inflammation, and changes in peripheral and central nervous system pain processing have been…

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Can Endometriosis Affect the Chance of Giving Birth to a Live Baby?

Can Endometriosis Affect the Chance of Giving Birth to a Live Baby? By Özge Özkaya

Deep infiltrating endometriosis and/or endometrioma diagnosed by transvaginal ultrasound is associated with a lower chance of giving birth to a live baby in patients undergoing their first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), according to a new…

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Understanding endometriosis pain

Understanding endometriosis pain By Eylül GÜN

Chronic pain, especially in conditions like endometriosis, poses significant challenges for diagnosis and treatment due to its multifaceted nature. Elina Helosvuori and Venla Oikkonen from Finland conducted a study in which they aimed to explore the complexities of chronic pain,…

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Neonatal uterine bleeding at birth and endometriosis later in life

Neonatal uterine bleeding at birth and endometriosis later in life By Selma Oransay

In the first few days after birth, some female newborns bleed from the vaginal route, and this is called newborn uterine bleeding. The overt and occult neonatal uterine bleeding prevalence rates are 3-5% and 25-60% retrospectively. The causative risk factors for…

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Could brain-derived neurotrophic factor (BDNF) be a potential marker of endometriosis ?

Could brain-derived neurotrophic factor (BDNF) be a potential marker of endometriosis ? By Nasuhi Engin Aydin

Medical student Kyana Jafarabady and academicians from several medical centers in Iran have published their database research on Brain-derived neurotrophic factor (BDNF) in endometriosis patients in a recent issue of BMC Women’s Health. BDNF is a neurotrophin that plays an important…

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Psychosocial Factors Must Be Taken Into Account When Dealing With Endometriosis

Psychosocial Factors Must Be Taken Into Account When Dealing With Endometriosis By Özge Özkaya

It is crucial to take into account both physical and psychosocial factors to maintain physical and mental health in patients with endometriosis, according to a new study published in the scientific journal Psychology & Health. “Treatment should address both pelvic…

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Endometriosis treatment at diagnosis: Is it possible?

Endometriosis treatment at diagnosis: Is it possible? By Eylül GÜN

For most cases of endometriosis, a diagnostic laparoscopy followed by a therapeutic laparoscopy is recommended by The National Institute for Health and Care Excellence. Hypothesizing that patients with endometriosis might benefit from receiving only a therapeutic laparoscopy, combining diagnosis and…

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Should I Have Endometriosis Surgery Before IVF-ICSI?

Should I Have Endometriosis Surgery Before IVF-ICSI? By Özge Özkaya

The live birth rate per in vitro fertilization (IVF) or intrauterine sperm injection (ICSI) cycle was significantly reduced in women who underwent surgery to treat endometriosis before the procedures, found a new study published in the scientific journal Reproductive Sciences.  “These…

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New visions on diaphragmatic endometriosis

New visions on diaphragmatic endometriosis By Nasuhi Engin Aydin

Elvin Piriyev and Thomas Römer from Academic Hospital Cologne Weyertal, Germany have published their retrospective analysis of diaphragm endometriosis in a recent issue of the European Journal of Obstetrics and Gynecology. About 7-10% of reproductive-age women have endometriosis but diaphragm…

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Bladder Function Alterations Following Endometriosis Surgery

 Bladder Function Alterations Following Endometriosis Surgery By Selma Oransay

Although endometriosis is a common gynecologic disorder, urinary tract involvement is present in only 1-5% of these patients. When endometriosis invades the urinary tract, clinical symptoms may vary from asymptomatic to frequency, urgency, bladder pain, hematuria, and recurrent urinary infections.…

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Complementary and alternative therapies for managing acyclic pelvic pain in women with endometriosis

Complementary and alternative therapies for managing acyclic pelvic pain in women with endometriosis By Hale Goksever Celik

The quality of life in women with endometriosis is affected depending on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Because of different clinical spectrum and diagnostic delays, there is no optimum management…

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Effects of Perceived Loneliness in Endometriosis

Effects of Perceived Loneliness in Endometriosis By Özge Özkaya

Perceived loneliness directly affects quality of life, according to a new study conducted in women with endometriosis. It also plays a crucial role in mediating the effects of experiences that women find difficult to verbalize. “It is possible that endometriosis…

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Pregnancy outcomes of women with endometriosis/adenomyosis.

Pregnancy outcomes of women with endometriosis/adenomyosis. By Selma Oransay

Endometriosis and adenomyosis are diseases presented by ectopic growth of endometrial-gland-like tissues, which we can find in ovaries, pelvic organs, and myometrium. These diseases are causes of hypermenorrhea, dysmenorrhea, chronic pelvic pain, and infertility. Although the number of reports about…

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Beware of deep endometriosis involving ureter

Beware of deep endometriosis involving ureter By Nasuhi Engin Aydin

Dr. Vacaroiu and colleagues from the Romanian academic milieu have published a case report of urinary tract endometriosis that could have otherwise resulted in kidney failure when remained undiagnosed. This case appeared in a recent issue of the Journal of Clinical…

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Surgery Pivotal in Improving Quality of Life in Endometriosis Patients

Surgery Pivotal in Improving Quality of Life in Endometriosis Patients By Özge Özkaya

Surgery plays a pivotal role in improving the quality of life of women with endometriosis who have previously not responded to medical therapy. This is according to a new study published in the Journal of Minimally Invasive Gynecology. During the…

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A unique approach for visualising endometriosis during surgery

A unique approach for visualising endometriosis during surgery By Nasuhi Engin Aydin

Dr. Jing Peng and associates from Shangai, China have made an experimental study on precise visualization of endometriotic lesions with gonadotropin-releasing hormone analog-modified indocyanine green, publishing their results in the Journal of Molecular Imaging.  Surgical interventions are important aspects of…

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Risk of endometriosis and related occupational factors among working women

Risk of endometriosis and related occupational factors among working women By Eylül GÜN

As a debilitating disease, endometriosis is well known to have effects on the patient's overall quality of life. Various studies have consistently reported that working women face an increased risk of endometriosis growth. Lee et al. from Korea conducted a…

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Ovarian adhesion prevention with polytetrafluoroethylene during endometrioma surgery.

Ovarian adhesion prevention with polytetrafluoroethylene during endometrioma surgery. By Selma Oransay

The World Health Organization defined infertility as the inability to conceive after 12 months of regular unprotected intercourse or after six months of fertility-focused intercourse. Depending on the chronic inflammatory character and causing adhesion formations within the peritoneum, endometriosis is…

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Peritoneal fluid in young women with endometriosis

Peritoneal fluid in young women with endometriosis By Selma Oransay

Many blood substances are present in peritoneal fluid due to their derivation from the transudation of blood through the peritoneal surface. Ectopic endometriotic lesions can also change the medium to contribute to the definition of the local environment of the…

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Why is there a higher risk of stroke for women with endometriosis?

Why is there a higher risk of stroke for women with endometriosis? By Eylül GÜN

Women diagnosed with endometriosis might face an increased susceptibility to stroke due to alterations in the levels of some molecules in their systems. Studies indicate that especially those undergoing hysterectomy/oophorectomy, have an approximately 30% higher risk of stroke. Dr. Mormile…

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Endometriosis and the risk to have mental disorders

Endometriosis and the risk to have mental disorders By Hale Goksever Celik

The most common clinical findings of endometriosis patients are pelvic pain and fertility problems, resulting in impairment of quality of life. These women are also affected regarding psychological health due to disease-associated symptoms. Dr. Wang et al., from Taiwan, published…

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Study Identifies Potential New Theraputic Target in Endometriosis

Study Identifies Potential New Theraputic Target in Endometriosis By Özge Özkaya

Lactate could drive the progression of endometriosis by upregulating the expression of a gene called HMGB1, according to a new study published in the Journal of Biomedical Research. This finding identifies novel targets for the prevention and treatment of endometriosis.…

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Is Your Surgeon Stressed?

Is Your Surgeon Stressed? By Özge Özkaya

Stress during endometriosis surgery among surgeons is greater than what they anticipate, according to a new study published in the scientific journal Acta Obstetricia et Gynecologica Scandinavica. The stress symptoms reported by surgeons start before surgery and is more common among…

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Endometriosis and the risk of breast cancer

Endometriosis and the risk of breast cancer By Selma Oransay

An increased risk of cancer with endometriosis has been in the attention field of endometriosis researchers since 1925, starting with Sampson. Several large meta-analyses supported the increased risk of clear cell and endometrioid ovarian cancer in women with deep infiltrating endometriosis. Breast…

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A herbal product has promising results in experimental endometriosis

A herbal product has promising results in experimental endometriosis By Nasuhi Engin Aydin

Neroli oil (bitter orange) is a nontoxic volatile substance from the flowers of Citrus aurantium that belongs to the Rutaceae family. This oil has notable anti-inflammatory effects besides potent antioxidant activity with 100% singlet oxygen scavenging activity. Contemporary pathophysiological views…

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Analysis of steroid hormone receptors in endometriotic tissues reveals chaotic results

Analysis of steroid hormone receptors in endometriotic tissues reveals chaotic results By Nasuhi Engin Aydin

  A group of researchers from academic institutions located at Australia and New Zeland, led by Dr. Holdsworth-Carson, have published their recent findings on steroid receptors in peritoneal endometriosis lesions by immunohistochemistry, in the journal Reproduvtive Biomedicine Online.  Endometriosis is…

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The effect of medical treatment on sexual function and quality of life in women with endometriosis

The effect of medical treatment on sexual function and quality of life in women with endometriosis By Hale Goksever Celik

Women with endometriosis suffer from dysmenorrhea, dyspareunia and chronic pelvic pain, all of which has significant negative consequences on their physical and psychological health regarding sexual function, work and social relationships. Biasioli et al. from Italy, published an article entitled…

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Family history of endometriosis and its characteristics

 Family history of endometriosis and its characteristics By Selma Oransay

Depression and migraine are two familial disorders affected by menstrual cycle and endometriosis patients have an increased likelihood of suffering from these comorbidities. A correlation of endometriosis, migraine and depression has been already reporteed in the literature, however a link for…

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Study Finds Link Between Exposure to Pollutants and Increased Riks of Endometriosis

Study Finds Link Between Exposure to Pollutants and Increased Riks of Endometriosis By Özge Özkaya

High concentrations of polycyclic aromatic hydrocarbons in urine may be associated with a higher risk of endometriosis, according to a new study published in the scientific journal Environmental Science and Pollution Research. The study also found that the concentration of…

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"Ovarian Reserve Markers" in Peritoneal Endometriosis

By Selma Oransay

Endometriosis-related subfertility is attributed to multiple factors, including mechanical obstructions, adhesions, pelvic inflammation, and diminished ovarian reserve. Serum anti-Mullerian hormone (AMH) levels and ovarian antral follicle counts (AFC) currently serve as fertility markers to diagnose decreased ovarian reserve and failure.…

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Robotic Surgery For Endometriosis

Robotic Surgery For Endometriosis By Özge Özkaya

Robotic surgery is an option for the treatment of severe endometriosis, according to the results of a preliminary comparative study published in the Journal of Minimally Invasive Gynecology. However, the approach is associated with higher costs.  “Next studies should identify…

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Coupled torture due to endometriosis and depressive symptoms

Coupled torture due to endometriosis and depressive symptoms By Eylül GÜN

Endometriosis significantly impacts various aspects of women's lives including their physical and mental health, careers, and social relationships. Physically, it causes chronic pelvic pain and dyspareunia, affecting 5-10% of reproductive-age women and leading to infertility challenges and a substantial percentage…

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Quantification of nerve bundle density as a biomarker for endometriosis utilizing PGP9.5 immunostaining

Quantification of nerve bundle density as a biomarker for endometriosis utilizing PGP9.5 immunostaining By Nasuhi Engin Aydin

Scientists from Netherlands and Canada have published their authentic study on immunohistochemically assessed nerve fiber bundles of endometriotic tissues in a recent issue of  Frontiers in Reproductive Health. Endometriotic tissues have nerve fibers which are stimulated in inflammatory processes leading…

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The urgent need for research and compassionate care in endometriosis

The urgent need for research and compassionate care in endometriosis By Eylül GÜN

Endometriosis, a common yet little-known inflammatory disorder, has significant patient and public health impacts due to underinvestment in its research and care. Delayed diagnosis and inadequate care persist due to reliance on surgical methods and limited advancements in medical therapies.…

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Embryo Morphokinetics of Endometriotic Patients by Time Lapse Monitoring

Embryo Morphokinetics of Endometriotic Patients by Time Lapse Monitoring By Selma Oransay

Many studies showed adverse effects of endometriosis on oocyte quality due to increased apoptosis and dysregulation of molecular pathways related to the development and growth of granulosa cells resulting on developmental arrest in embryos of women with endometriosis. Time-lapse monitoring…

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Cells Constituting Endometriosis Have Different Properties

Cells Constituting Endometriosis Have Different Properties By Özge Özkaya

Many cell types are altered in endometriosis, found a new study published in the Journal of Pathology. The study also found that depending on the subtype of endometriosis, endometriosis cells show signatures of estrogen responsiveness, immunologic cytotoxicity, and proinflammation. Finally, it identified…

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Novel high-risk candidate genes for familial endometriosis

Novel high-risk candidate genes for familial endometriosis By Hale Goksever Celik

Endometriosis is a chronic inflammatory disease with a genetic background resulting in familial clustering. Although multiple susceptibility loci have been identified in genome-wide association studies, high-risk predisposing variants have not been defined yet. A group of scientists from Finland, published a study…

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Gene Expression Profiles of Endometriosis and Personalized Treatment

Gene Expression Profiles of  Endometriosis and Personalized Treatment By Bahar Yuksel

The study lead by Dr.McKinnon from the Institute for Molecular Bioscience, The University of Queensland, Australia, aimed to understand the gene expression profiles of different endometriosis lesion subtypes and their response to hormonal treatment. The researchers analyzed gene expression data…

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Perception of quality of professional healthcare in Italian patients with endometriosis

 Perception of quality of professional healthcare in Italian patients with endometriosis By Selma Oransay

According to the Italian Ministry of Health, the prevalence rate of endometriosis among women in their reproductive age is 10-15%. Many of them suffer from intense pain and a poor quality of life due to diagnostic delay. The average delay…

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Increasing awareness of the scientific community on nano-particles for endometriosis.

Increasing awareness of the scientific community on nano-particles for endometriosis. By Nasuhi Engin Aydin

Academicians from various disciplines from multiple Italian institutions have published their review on the possible role of nanotechology to deal with the management of endometriosis in a recent issue of scientific periodical Nanoscale. Nanotechnology is the science and engineering where…

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Neurotrophins proposed as possible biomarkers for endometriosis

Neurotrophins proposed as possible biomarkers for endometriosis By Eylül GÜN

As the search for a good-quality biomarker in endometriosis continues, certain growth factors have been investigated for their roles in the pathophysiology of the disease. Neurotrophins, as regulators of neuronal development and survival, are also known to take part in…

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Diagnosis and the Treatment of Postmenopausal Endometriosis

Diagnosis and the Treatment of Postmenopausal Endometriosis By Selma Oransay

About 190 million women around the world are diagnosed with endometriosis. The majority of the cases are between 30 and 40 years of age. After menopause, the incidence of endometriosis declines to 2-5%, and it is more common in women…

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Potential New Therapeutic Avenue for Deep Endometriosis

Potential New Therapeutic Avenue for Deep Endometriosis By Özge Özkaya

The use of lipid nanoparticles carrying methotrexate seems to be safe and feasible in women with deep infiltrating endometriosis, according to a new study published in the scientific journal Archives of Gynecology and Obstetrics. The approach could, therefore, be a new…

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A non-invasive test to determine the risk of endometriosis in women having chronic pelvic pain or unexplained infertility

A non-invasive test to determine the risk of endometriosis in women having chronic pelvic pain or unexplained infertility By Hale Goksever Celik

Women having endometriosis may suffer from chronic pelvic pain and/or infertility, both of which diminish the quality of life in these women. Minimalization of the time between the onset of symptoms and diagnosis is essential to improve patients’ lives. However,…

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Could H1-antihistamines be beneficial in endometriosis management ?

Could H1-antihistamines be beneficial in endometriosis management ? By Nasuhi Engin Aydin

K. B. Manthra, PhD, a postdoctoral researcher from the University of Minnesota has written a “clinical opinion” in a recent issue of the periodical American Journal of Obstetrics and Gynecology, Global Reports. Endometriosis is currently regarded as a chronic inflammatory…

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Quality of life analyses among women with endometriosis

 Quality of life analyses among women with endometriosis By Selma Oransay

Clinical factors that may affect the quality of life in women with endometriosis are mental health, sexual life, working capacity, and social relations. Symptom severity, especially dysmenorrhea, heavy periods, pelvic pain, and infertility complaints, are the most disturbing factors in…

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New developments in endometriosis from a molecular and cellular standpoint

New developments in endometriosis from a molecular and cellular standpoint By Eylül GÜN

Researchers are making significant progress in endometriosis regarding molecular and cellular research, with collaborative efforts by clinicians, scientists, surgeons, and biostatisticians. Laganà et al. from Italy wrote an editorial regarding the recent special issue called "Molecular and Cellular Advances in Endometriosis Research…

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The type of surgical approach compared to complications and recurrence for colorectal endometriosis

The type of surgical approach compared to complications and recurrence for colorectal endometriosis By Hale Goksever Celik

Women with endometriosis may have extension and infiltration of the intestine, called "colorectal endometriosis, in up to 12%. The main symptoms are alterations in bowel habits, pelvic pain, and/or infertility. The gold standard management option for colorectal endometriosis is surgical…

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Deep infiltrating endometriosis and postoperative pregnancy outcomes

Deep infiltrating endometriosis and postoperative pregnancy outcomes  By Selma Oransay

Although the current ESHRE guidelines state that there is no strong evidence to support surgical intervention to improve the spontaneous pregnancy rate in women with deep infiltrating endometriosis and advise Assisted reproduction technology irrespective of the severity of endometriosis, several studies…

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Reviewing all you want to know on endometriosis !

Reviewing all you want to know on endometriosis ! By Nasuhi Engin Aydin

Academicians from the International University of Sarajevo, Bosnia, and Lincoln Medical School, UK have written a comprehensive updated review on endometriosis covering many aspects of endometriosis and published their paper as an open-access manuscript in the journal “Pathology-Research and Practice”. …

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A synopsis of deep infiltrating endometriosis of the digestive system

A synopsis of deep infiltrating endometriosis of the digestive system By Eylül GÜN

The gastrointestinal tract is one of the most common locations of extrapelvic endometriosis. Its infiltrative counterpart exhibits more aggressive behavior and often needs to be distinguished from malignancies clinically. Yin et al. from Harbin, China reviewed the latest findings regarding…

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Blood-based biomarkers for the detection of endometriosis and adenomyosis

Blood-based biomarkers for the detection of endometriosis and adenomyosis By Eylül GÜN

One of the biggest challenges in endometriosis management is the delay in diagnosis. Scientists have been trying to come up with biomarkers to detect it quicker. Thinking blood-based biomarkers could aid in earlier diagnosis and help with the duly administration…

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Monitoring eating behavior is important

Monitoring eating behavior is important By Selma Oransay

The relationship between dietary products and endometriosis gained interest after the recognition that a proper diet can improve pathological and physiological processes. There is also a belief that the benefits of some anti-oxidants may have a therapeutic effect on the…

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Asia-Pacific: Expert panel's suggestions for improving endometriosis-related health issues

Asia-Pacific: Expert panel's suggestions for improving endometriosis-related health issues By Nasuhi Engin Aydin

"Endometriosis should be diagnosed as early as possible for the sake of the patients" and the Asia-Pacific Endometriosis Expert Panel sought to address the reasons for diagnostic delays in this part of the world and published a consensus report in…

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Mediterranean Diet Associated With Less Endometriosis Pain?

Mediterranean Diet Associated With Less Endometriosis Pain? By Özge Özkaya

There seems to be a link between pain relief in endometriosis and a Mediterranean diet, according to a new study published in the International Journal of Science. This finding suggests that a Mediterranean diet could help manage chronic pain in…

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Sacral neuromodulation for endometriosis-related chronic pelvic pain

Sacral neuromodulation for endometriosis-related chronic pelvic pain By Selma Oransay

Sacral neuromodulation is a therapeutic technique that involves electrical stimulation of a sacral nerve route to modulate a neural pathway. The device is an implantable neurostimulator, and the procedure is a minimally invasive procedure with good long-term outcomes. This technique…

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Endometriosis in Asia

Endometriosis in Asia By Nasuhi Engin Aydin

Academicians from the University of Philippines led by Dr. Velarde have published a recent review on endometriosis and Asian women in the scientific periodical “Endocrine Connections”. The endometriosis prevalence rate is variable among ethnicities, and Asian women including Filipinos, Indians, Japanese,…

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The Importance of "uterine adenogenesis" in endometriosis development

The Importance of By Eylül GÜN

Understanding the complex pathogenetic mechanisms underlying endometriosis has been a big challenge. Several studies have demonstrated that the eutopic and ectopic endometrium exhibit distinct characteristics. Researchers led by Signorile et al. from Italy conducted a review of the recent developments…

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No increased risk of major postoperative complications in women operated by experienced surgeons in endometriosis centers

No increased risk of major postoperative complications in women operated by experienced surgeons in endometriosis centers By Hale Goksever Celik

Recurrent surgery may be needed in up to 35% of endometriosis patients. The reason for repeated surgery may be residual or recurrent disease. In other words, multiple surgical procedures are a common phenomenon for women having endometriosis. Knowing the impact…

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The overlap of endometriosis and polycystic ovarian syndrome

The overlap of endometriosis and polycystic ovarian syndrome By Eylül GÜN

Polycystic ovarian syndrome (PCOS) is one of the most common causes of female subfertility similar to endometriosis. It has been hypothesized that owing to the underlying pathophysiological mechanisms, women with endometriosis are at a greater risk of having PCOS than…

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Hazardous substances in pollution and relationship with endometriosis.

Hazardous substances in pollution and relationship with endometriosis. By Selma Oransay

Vallée and colleguages. from the Department of Epidemiology and Public Health of Foch Hospital, France, recently published a narrative review about environmental pollution and its association with endometriosis in BJOG. They used the existing English literature to discuss the association…

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Clinical Trial Tested Safety of Potential New Drug to Manage Endometriosis

Clinical Trial Tested Safety of Potential New Drug to Manage Endometriosis By Özge Özkaya

The non-peptide gonadotropin-releasing hormone antagonist SHR7280 has favorable safety, pharmacokinetics, and pharmacodynamics in 3 different doses, according to the results of a phase 1 clinical trial published in the scientific journal Clinical Pharmacokinetics. “The results of this study provide evidence to…

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Endometriosis and breast cancer- love or hate?

Endometriosis and breast cancer- love or hate? By Bahar Yuksel

Many studies have been conducted to investigate the relationship between endometriosis and breast cancer, but no definitive conclusion has been reached yet. In the study co-authored by Yan and Li et al, endometriosis-related GWAS data was used to determine the…

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Robotic Surgery Not Linked With More Complications in Certain Cases

Robotic Surgery Not Linked With More Complications in Certain Cases By Özge Özkaya

Robotic-assisted excision surgery to treat large rectal endometriotic nodules larger than 3 cm is not associated with a higher risk of complications following the operation compared to conventional laparoscopy, according to a new study published in the journal Colorectal Diseases.…

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Live Birth Rate for ovarian stimulation protocols after laparoscopic endometrioma cystectomy.

Live Birth Rate for ovarian stimulation protocols after laparoscopic endometrioma cystectomy. By Selma Oransay

The laparoscopic cystectomy of the ovaries is the first-line infertility treatment in patients with endometriomas. However, a possible diminished ovarian capacity after cystectomy with ovarian failure to respond to the gonadotropin stimuli seems an undesirable result of this procedure. Controlled…

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A suggestion for a novel in vitro diagnostic test for endometriosis

A suggestion for a novel in vitro diagnostic test for endometriosis By Eylül GÜN

As the research continues to find a gold standard non-invasive diagnostic method for endometriosis, there still is no definitive answer. One of the most commonly studied markers is Cancer Antigen 125 (CA125) – a biomarker that is secreted from the…

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Underestimation of Dysmenorrhea in adolescents

Underestimation of Dysmenorrhea in adolescents By Hale Goksever Celik

Women with endometriosis may suffer from painful symptoms, especially during menstruation or sexual intercourse. One of the main etiologic reasons for secondary dysmenorrhea is endometriosis, and it has a poor impact on life quality. Underestimation of dysmenorrhea and consideration of…

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Menstruating eye: Very rare but possible

Menstruating eye: Very rare but possible By Eylül GÜN

Extragenital cyclical bleeding during a menstrual cycle is called vicarious menstruation and it is mostly reported to be seen in the nasal mucosa but can involve any other organ such as the lungs, stomach, kidney, etc. Endometriosis is a common…

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Perioperative complications of outpatient surgery for endometriosis.

Perioperative complications of outpatient surgery for endometriosis. By Selma Oransay

Surgical treatment of endometriosis plays an essential role in managing the disease. They are miscellaneous perioperative complications such as incomplete removal of the lesions, low quality of the first surgery, or incorrect approach to laparoscopic surgeries that result in increased…

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Vicious cycle: The promoting role of previous endometriosis foci for new lesions

Vicious cycle:  The promoting role of previous endometriosis foci for new lesions By Nasuhi Engin Aydin

An experimental animal study on the pathogenesis of endometriosis from the Institute for Clinical and Experimental Surgery, Saarland University, Hamburg has been published in a recent issue of International Journal of Molecular Sciences. Endometriosis is a well-known common gynecological ailment…

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Comparison of two different surgical approach to deep colorectal endometriosis in terms of postoperative outcomes.

Comparison of two different surgical approach to deep colorectal endometriosis in terms of postoperative outcomes. By Selma Oransay

Deep colorectal endometriosis affects one-fifth of women with endometriosis, which is commonly associated with more pelvic pain and severe gastrointestinal symptoms. Three surgical approaches for deep colorectal endometriosis are segmental colorectal resection, full-thickness discoid resection, and shaving operation. Choosing the…

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Women With Endometriosis Willing to Participate in Research

Women With Endometriosis Willing to Participate in Research By Özge Özkaya

Women with endometriosis are open to participating in research, according to a new Australian study published in the journal "Medicina (Kaunas)". This way, they said, “they felt aligned with their needs, with a significant focus on diagnostic tools and symptom…

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The relationship between lipids and estrogen in endometriosis

The relationship between lipids and estrogen in endometriosis By Eylül GÜN

Lipid metabolism plays important roles in many physiological and pathological conditions such as the storage of energy, immune system functions, steroid hormone production, inflammation, and chronic diseases such as diabetes mellitus and hyperlipidemia. In an attempt to figure out the…

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Omitted facet of endometriosis : mental health related to stigma

Omitted facet of endometriosis : mental health related to stigma By Nasuhi Engin Aydin

A team of clinical psychologists involved in women’s health led by Deniz Kocas has published a recent review on the mental health aspect of endometriosis patients in the European Journal of Obstetrics & Gynecology and Reproductive Biology. Endometriosis is a notoriously…

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Peritoneal Endometriosis and Acyclical pelvic pain

Peritoneal Endometriosis and Acyclical pelvic pain By Eylül GÜN

The most debilitating symptom of endometriosis is chronic pelvic pain. The peripheral nervous system is affected and the growth and regeneration of sensory nerve fibers in endometriotic tissue has been identified. The first line treatment which is hormonal therapy for…

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Endometrioma surgery and the ovarian reserve

Endometrioma surgery and the ovarian reserve By Selma Oransay

Traditionally, cystectomy is the gold standard for surgical approach owing to the reduced risk of recurrence. Still, it may lead to a reduction in postoperative ovarian volume and can be a cause of ovarian failure. The recent conservative surgical management of…

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Peritoneal endometriosis and Peritoneal Immunity

Peritoneal endometriosis and Peritoneal Immunity By Selma Oransay

The peritoneum is an important immune barrier where, under normal conditions, it is balanced. External stimuli cause pro-inflammatory responses. To bring balance to this undesired situation, anti-inflammatory factors come into play. However, in patients with endometriosis, cytotoxicity of T lymphocytes,…

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Endometriosis Associated With Metabolic Syndrome

Endometriosis Associated With Metabolic Syndrome By Özge Özkaya

There seems to be a link between endometriosis and metabolic conditions, according to a new study published in the scientific journal Gynecological Endocrinology. This finding suggests that close attention should be paid to metabolic conditions in women with endometriosis and…

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Endometriosis and Physical Activity

Endometriosis and Physical Activity By Hale Goksever Celik

Endometriosis causes abstinence from their daily life, especially during painful periods. Decreased physical function might result in reduced physical activity. Sachs et al., from Switzerland, published a study titled “Physical Activity in Women with Endometriosis: Less or More Compared with…

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Alterations of mitochondrial dynamics in endometriosis

Alterations of mitochondrial dynamics in endometriosis By Eylül GÜN

Mitochondria are known as the batteries of the cell with the ATP that they produce through oxidative phosphorylation. Mitochondrial dynamics are important mechanisms for mitochondria to maintain their integrity by continuously undergoing changes. Mitochondrial fusion is the joining of two…

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Exploring endometriosis symptoms and their effects on women's lives

Exploring endometriosis symptoms and their effects on women's lives By Eylül GÜN

Endometriosis symptoms, their severity, and the way they affect patients' lives may vary. With the aim of investigating different personal experiences and perceptions of endometriosis symptoms and the way they impact women's daily lives, Hunsche and colleagues from Switzerland and…

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Healthcare Seeking Behaviour May Be Sign of Endometriosis

Healthcare Seeking Behaviour May Be Sign of Endometriosis By Özge Özkaya

Women with endometriosis had a higher utilization of primary and secondary healthcare in the 10 years before receiving a diagnosis, found a new study published in the scientific journal Human Reproduction.  “With this knowledge, healthcare professionals could be better at relating…

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Elevated iron levels in "endometriosis pathogenesis"

Elevated iron levels in By Selma Oransay

The presence of abnormal levels of iron and ferritin in endometriotic lesions is likely due to repeated bleeding episodes. When red blood cells break down, the iron content is released, which can cause inflammation leading to damage to surrounding tissues.…

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A pioneering study on clinicopathologic features of biopsies of endometriotic lesions

A pioneering study on clinicopathologic features of biopsies of endometriotic lesions By Nasuhi Engin Aydin

Deep infiltrating endometriosis, where endometriotic lesions have an invasion depth of ≥5mm to the underlying tissues, is well known due to the troublesome features, peritoneal endometriosis is very common and widely distributed by superficial involvement in the pelvic visceral and…

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The Molecular Mechanisms of how herbal medicine Actaea racemosa modulates Endometriosis Progression

The Molecular Mechanisms of how herbal medicine Actaea racemosa modulates Endometriosis Progression By Bahar Yuksel

Increased proliferation, dysregulated apoptosis, and a pro-inflammatory and oxidative environment are the hallmarks of endometriosis. In the article published in the Journal of Molecular Sciences, penned by Livia Interdonato et al, the molecular mechanisms of the extract from a plant…

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Treatment of superficial dyspareunia using topical estrogens in postmenopausal women with a history of endometriosis

Treatment of superficial dyspareunia using topical estrogens in postmenopausal women with a history of endometriosis By Hale Goksever Celik

Genitourinary syndrome of menopause is defined as a collection of symptoms and signs caused by hypoestrogenic changes to the labia majora/minora, clitoris, vestibule/introitus, vagina, urethra, and bladder that occur in menopausal patients. Sexual dysfunction and superficial dyspareunia can be experienced…

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Assessing endometrial receptivity using menstrual blood samples in patients undergoing in-vitro fertilization

Assessing endometrial receptivity using menstrual blood samples in patients undergoing in-vitro fertilization By Eylül GÜN

Endometrial receptivity is the endometrium's capacity to allow the embryo the chance to adhere, infiltrate, and develop while ensuring an ideal microenvironment. When impaired, it is one of the two major factors contributing to infertility along with embryo quality by…

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A review for genetics of endometriosis.

A review for genetics of endometriosis. By Selma Oransay

There is an increased risk of developing endometriosis among first-degree relatives, which can raise suspicions of the role of genetic factors in endometriosis. Genome-wide association studies and next-generation sequencing have identified numerous genetic loci and variants relating to the disease.…

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A comparative analysis of male and female perspectives on sexuality in couples dealing with endometriosis

A comparative analysis of male and female perspectives on sexuality in couples dealing with endometriosis By Eylül GÜN

Sexual relationships of patients with endometriosis have been an area of research lately, however, studies have focused mostly on female perceptions and opinions leaving out the males.  Helfenstein et al. from Switzerland, Germany, and Austria conducted a multicenter cohort study…

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Study May Explain How Tubal Endometriosis Causes Infertility

Study May Explain How Tubal Endometriosis Causes Infertility By Özge Özkaya

Tubal endometriosis damages the epithelial ultrastructure of the fallopian tubes or the tubes connecting the ovaries to the uterus along which an egg travels each month ready to be fertilized by a sperm cell. This could help explain why tubal…

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Is continuous hormonal treatment safe and healthy method for endometriotic patients?

Is continuous hormonal treatment safe and healthy method for endometriotic patients? By Selma Oransay

One of the studies related to the search for new markers in pathophysiologic causes of endometriosis is circulating microparticles and their subset "tissue factor". In response to damage, activation, or apoptosis, these microparticles are found in human plasma, urine, saliva,…

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Toxic metal cadmium and Endometriosis

Toxic metal cadmium and Endometriosis By Nasuhi Engin Aydin

Data analyst Mandy Hall and and colleagues from the Department of Epidemiology and Biostatistics, Michigan State University, USA, have published their results on cadmium levels and endometriosis in a recent issue of “Human Reproduction”. In 2020 the World Health Organization…

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Novel surgical solutions for catamenial pneumothorax

Novel surgical solutions for catamenial pneumothorax By Eylül GÜN

Catamenial pneumothorax is a spontaneous pneumothorax that occurs during or right after menstruation and is thought to be caused by thoracic endometriosis that includes the diaphragm, lung, and parietal pleura. The solution is surgical removal of endometrial lesions, however, a…

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A new classification called ENDOGRADE to rate surgical complexity in deep endometriosis.

A new classification called ENDOGRADE to rate surgical complexity in deep endometriosis. By Selma Oransay

Correlation with patient outcomes could not be identified in most endometriosis classification systems including the commonly used revised ASRM. Therefore, in addition to grading the depth and invasion pattern of the lesions, there is a need for a classification system to…

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Preoperative flexible sigmoidoscopy in patients with deep infiltrating endometriosis

Preoperative flexible sigmoidoscopy in patients with deep infiltrating endometriosis By Hale Goksever Celik

Deep infiltrating endometriosis is defined as endometriotic lesions extending 5 mm or more below the peritoneal surface. Women with deep endometriosis have rectovaginal lesions affecting the tissue adjacent to, or directly involving the rectum and/or rectosigmoid colon with a 90%…

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Women With Endometriosis More Likely to Also Have Non-Specific Symptoms

Women With Endometriosis More Likely to Also Have Non-Specific Symptoms By Özge Özkaya

Women with endometriosis are more likely to report menstrual symptoms, according to a new study published in the American Journal of Obstetrics and Gynecology. However, they are also at an increased risk of mental health disorders, other pain symptoms, bowel,…

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The compliance for post-surgical follow-ups after endometriosis surgery

The compliance for post-surgical follow-ups after endometriosis surgery By Selma Oransay

. The patient's adherence to follow-ups after surgery is essential as it is the only way to evaluate the surgery's benefits in improving pain symptoms and recurrences, measuring the quality of life, and fertility outcomes. . Dr. Szabo and his…

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Does ZEB1 Gene Expression Govern Endometriosis Infiltration Pattern?

Does ZEB1 Gene Expression Govern Endometriosis Infiltration Pattern? By Özge Özkaya

The expression of a gene called ZEB1 is different between different types of endometriosis, found a new study published in the European Journal of Obstetrics & Gynecology and Reproductive Biology. This could affect whether or not lesions become infiltrative.   More importantly,…

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Review of neutrophil based scientific research in endometriosis

Review of neutrophil based scientific research in endometriosis By Nasuhi Engin Aydin

Xinlei Wang and associates from Jilin University, Changchun, China, have published a comprehensive review on the pathogenetic role of neutrophils in endometriosis in a recent issue of the periodical  “Mediators of inflammation”. As a common inflammatory condition where endometrial tissue…

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Unveiling the Immunological Puzzle: Modulation of Biomarkers in Endometriosis by Progestin Therapy

Unveiling the Immunological Puzzle: Modulation of Biomarkers in Endometriosis by Progestin Therapy By Bahar Yuksel

The study by Daniela Roxana Matasariu et al., aimed to investigate the effects of progestin treatment on the expression of biomarkers in endometriosis, specifically focusing on osteopontin and CD44; and their potential role in the pathogenesis of endometriosis. The researchers…

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Moderate-to-severe Endometriosis and "The Cumulative live birth rate" in IVF Cycles

Moderate-to-severe Endometriosis and By Hale Goksever Celik

Infertility is one of the major symptoms in women with endometriosis. The incidence of endometriosis is approximately 10% in reproductive-aged women and up to 40-50% in infertile women. There are multifactorial mechanisms resulting in endometriosis-associated infertility such as anatomic distortion, impaired…

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"Transumblical single-port laparoscopy" for deep infiltrating endometriosis.

By Selma Oransay

Deep infiltrating endometriosis patients have multi-system involvements, severe pelvic adhesions, and pelvic pain. Dyspareunia, dysmenorrhea, infertility, gastrointestinal symptoms, and lower urinary tract symptoms seriously affect their quality of life. Although hormonal therapy may be the first choice for treating endometriosis,…

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The public plea of international group of "endometriosis experts"

The public plea of international group of By Nasuhi Engin Aydin

A group of international “endometriosis experts” led by Professor Philippe R. Koninckx from Belgium, have published their unique scientific paper “The 10 “Cardinal Sins” in the Clinical Diagnosis and Treatment of Endometriosis: A Bayesian Approach” in a recent issue of…

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Role of peritoneal dendritic cells in endometriosis development

Role of peritoneal dendritic cells in endometriosis development By Eylül GÜN

Dendritic cells (DCs), essential antigen-presenting cells bridging innate and adaptive immunity, play a pivotal role in immune response modulation. They capture process, and present antigens, facilitating T-cell activation. DCs also promote self-tolerance by releasing tolerogenic cytokines, contributing to autoimmune disease…

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Dienogest versus combined oral contraceptives treatment in postoperative endometriosis care

Dienogest versus combined oral contraceptives treatment in postoperative endometriosis care By Selma Oransay

Dienogest is a synthetic progestin derivative, like oral contraceptives, used to prevent endometriosis recurrence after surgery. Randomized clinical trials verified a significantly higher reduction in endometriotic lesions, clinical symptoms, and improved quality of life obtained when dienogest was given to…

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Endometriosis of the skeletal muscular system

Endometriosis of the skeletal muscular system By Eylül GÜN

Endometriosis of the skeletal muscular system (ESMS) is characterized by the presence of endometrial cells in skeletal muscles, bones, or joints. Despite its rare occurrence, ESMS has been reported in various muscle and joint locations, leading to atypical symptoms and…

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New SMS Program Available for Endometriosis Patients

New SMS Program Available for Endometriosis Patients By Özge Özkaya

Researchers from Australia developed a supportive short message service (SMS) program for endometriosis patients. The program aims to support women living with endometriosis to manage their condition. The program called 'EndoSMS" was designed based on the needs and preferences of…

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A Starch-Based Gel Barrier Reduces Pain and Improves Fertility After Endometriosis Surgery

A Starch-Based Gel Barrier Reduces Pain and Improves Fertility After Endometriosis Surgery By Özge Özkaya

The development of pain was reduced in women with endometriosis who underwent surgery for deep infiltrating endometriosis (DIE) resection and the "gel barrier 4DryField® PH" was used during the operation, according to results from a randomized controlled trial. Moreover, fertility was improved. "4DryField® PH"…

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Are women with endometriosis more prone to pregnancy loss?

Are women with endometriosis more prone to pregnancy loss? By Hale Goksever Celik

Endometriosis is a gynecological disease of reproductive-aged women who may suffer from reproductive outcomes such as infertility, miscarriage, and recurrent pregnancy loss. Pregnancy loss is the spontaneous loss of a pregnancy until 22 weeks of gestation including spontaneous abortion, missed…

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Telemedicine for endometriosis

Telemedicine for endometriosis By Eylül GÜN

The COVID-19 pandemic led to the widespread adoption of telemedicine, allowing healthcare professionals to provide care remotely using technology. Telemedicine has proven successful in various medical fields. In obstetrics and gynecology, implementing telemedicine became crucial, especially for conditions like endometriosis.…

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Harnessing the Power of the Immune System: The Potential of Immunotherapy for Treating Endometriosis

Harnessing the Power of the Immune System: The Potential of Immunotherapy for Treating Endometriosis By Bahar Yuksel

The review article by Wenshu Li et al. discusses the potential of immunotherapy as a novel treatment for endometriosis and the potential to overcome possible side effects and recurrence rates related to conventional therapies. The article explains how immunotherapy, which…

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Postoperative outcomes of laparoscopic rectosigmoid resection for bowel endometriosis.

Postoperative outcomes of laparoscopic rectosigmoid resection for bowel endometriosis. By Selma Oransay

Rectosigmoid endometriosis comprises 80-85% of all bowel endometriosis cases and can be localized in the rectovaginal septum, uterosacral ligaments, retro-cervical region, and parametrium. Symptoms of rectosigmoid endometriosis include abdominal bloating, constipation-diarrhea, lower-back pain, dyschezia, and sometimes cyclic rectal bleeding. Minimally…

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Ultrasound and #Enzian Classification for Endometriosis

Ultrasound and #Enzian Classification for Endometriosis By Özge Özkaya

The #Enzian classification can ensure endometriosis is systematically described and classified, which can “greatly facilitates communication between physicians and patients, sonographers and surgeons,” according to an editorial article by Drs. Jörg Keckstein and Markus Hoopmann published in the European Journal of…

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Pain Scoring System for Deep Endometriosis

 Pain Scoring System for Deep Endometriosis By Selma Oransay

The numeric pain scale is commonly used to interpret pain score values. According to the National Comprehensive Cancer Network guidelines, pain scores of 4-7 points indicate moderate, and  8-10 points indicate severe pain. Patients with a local pain score of…

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Sexual activity during menstruation: Any impact on endometriosis development?

Sexual activity during menstruation: Any impact on endometriosis development? By Eylül GÜN

Retrograde menstruation is among the theories for the etiology of endometriosis and there is a hypothesis that sexual activity during menstruation could potentially increase retrograde menstruation, leading to the implantation of endometrial tissue in other areas and consequently increasing the…

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Ovarian cancers arising in endometriosis: still an unresolved issue

Ovarian cancers arising in endometriosis: still an unresolved issue By Nasuhi Engin Aydin

Alice Bergamini and associates from San Raffaele Scientific Institute, Milan, Italy have published their results on clinicopathologic features of endometriosis-associated ovarian cancers in a recent issue of the journal “Diagnostics”. The association between endometriosis and ovarian cancer was first noticed…

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Outcomes of improving chronic pelvic pain with "immersive digital therapeutics" at home.

Outcomes of improving chronic pelvic pain with By Selma Oransay

Studies have shown that virtual reality can effectively treat acute pain experienced by burn victims, during labor, dental surgery, or for chronic musculoskeletal, neuropathic, and cancer pain. Considering the effectiveness of treating chronic pelvic pain at home, Merlot et al.…

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Endometriosis and Genetic Polymorphisms in Proinflammatory Cytokines

Endometriosis and Genetic Polymorphisms in Proinflammatory Cytokines By Hale Goksever Celik

Several pathophysiological mechanisms have been proposed for the chronic inflammatory nature of endometriosis, such as retrograde menstruation, coelomic metaplasia, hormonal change, oxidative stress and inflammation, immune dysfunction, and apoptosis suppression. One of the most widely accepted theories in recent years…

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Autoimmune Disorders in Women with Endometriosis May Impair Embryo Implantation

Autoimmune Disorders in Women with Endometriosis May Impair Embryo Implantation By Bahar Yuksel

The retrospective study by Noemi Salmeri reports the effect of concomitant autoimmune disorders on the ability of the endometrium to support embryo implantation in women with endometriosis who underwent assisted reproductive technology (ART) treatments. The study involved 600 women with…

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A new potential biomarker proposal from leukorrhea of endometriosis patients

A new potential biomarker proposal from leukorrhea of endometriosis patients By Eylül GÜN

Endometriosis is typically diagnosed through laparoscopic surgery, which can be invasive and discourages some patients from participating. Therefore, there is a need for a non-invasive diagnostic method. Exosomes, small vesicles containing biological information, can be found in almost every type…

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Outcomes of chronic pelvic pain after niche repair

Outcomes of chronic pelvic pain after niche repair By Selma Oransay

Rapidly increasing cesarian section rates in recent years increased the cesarian scar defects and the development of "isthmoceles". Isthmocele is a myometrial lesion located around the isthmic portion of the uterus that is a myometrial discontinuity or hypoechoic triangle in…

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Conditioned medium from adipose tissue derived stem cells for endometriosis treatment

Conditioned medium from adipose tissue derived stem cells for endometriosis treatment By Eylül GÜN

Despite the effectiveness of both surgical and medical treatments in addressing complications related to endometriosis, there is still a high recurrence rate indicating the need for the development of novel therapeutic approaches to enhance the effectiveness of endometriosis treatment. Adipose-derived…

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Preoperative MRI Scoring System Could Ensure Women Are Fully Informed

Preoperative MRI Scoring System Could Ensure Women Are Fully Informed By Özge Özkaya

The Deep Pelvic Endometriosis Index is able to predict the length of surgery and hospital stay as well as complications following surgery including voiding dysfunction, according to a new multicenter cohort study, the results of which were published in The Journal…

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Changes over time in day surgery for endometriosis in Canada

Changes over time in day surgery for endometriosis in Canada By Hale Goksever Celik

There are several medical and surgical treatment options for the management of endometriosis. Surgical approach is generally preferred in women with atypical endometrioma appearance on ultrasound, and who have persistent pain despite medical treatment. Surgery is often the first choice…

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Getting help from water to replace colonoscopy and MRI for the diagnosis of deep bowel endometriosis.

Getting help from water to replace colonoscopy and MRI for the diagnosis of deep bowel endometriosis. By Bahar Yuksel

This retrospective study by Martyna Masternak et al. discusses the use of rectal water contrast transvaginal ultrasound (RWC-TVS) as a tool for assessing deep bowel endometriosis. The study explains how the procedure is minimally invasive, and how it involves filling…

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Menopause-management strategies for women with endometriosis.

Menopause-management strategies for women with endometriosis. By Selma Oransay

Menopausal hormonal therapy is the most effective treatment for menopausal symptoms, such as hot flushes, sweating, sleep disturbances, mood changes, and joint pain. Approximately 75% of all women experienced some degree of these symptoms, while 2-4% were diagnosed with endometriosis. Menopausal…

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Questionnaire Can Assess Patient-Centerdness of Endometriosis Care

Questionnaire Can Assess Patient-Centerdness of Endometriosis Care By Özge Özkaya

European patients with endometriosis think that “reaching a diagnosis quickly” and “physicians demarcating the endometriosis complexity level which they can treat” are important aspects of their care, according to a new study published in the scientific journal Best Practice & Research…

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Melatonin for endometriosis-associated pain

Melatonin for endometriosis-associated pain By Eylül GÜN

Treatment options for endometriosis-associated pain include analgesics, hormonal therapy, and surgery. However, these treatments may be ineffective for some women, leading to a search for alternative approaches. Melatonin, a hormone involved in regulating sleep-wake cycles, possesses anti-inflammatory, analgesic, and anti-estrogenic…

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Spheroids: 3D-mini-models for Understanding Endometriosis

Spheroids: 3D-mini-models for Understanding Endometriosis By Bahar Yuksel

The pathogenesis of endometriosis is not fully understood, and there is a need for better models to study the disease. Spheroids are 3D clusters of cells that mimic the structure and function of endometrial tissue. These mini models have several…

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New Model Can Help Understand How Endometriosis-Associated Ovarian Cancer Develops

New Model Can Help Understand How Endometriosis-Associated Ovarian Cancer Develops By Özge Özkaya

Researchers from Japan and the US developed a new mouse model in collaboration, that can be useful to better understand how endometriosis-associated ovarian cancer develops. This new model can help to assess new treatment options for both diseases. The team…

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Limitations of current surgical classification systems for endometriosis.

Limitations of current surgical classification systems for endometriosis. By Selma Oransay

Many classification systems for endometriosis have been developed since the 1970s, and in a 2021 review, more than 20 of those systems were identified. The best-known and most frequently used are rASRM (revised  American Society of Reproductive Medicine), the Enzian…

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Meningioma risk in women with endometriosis using Nomegestrol acetate

Meningioma risk in women with endometriosis using Nomegestrol acetate By Hale Goksever Celik

Women with endometriosis mostly suffer from symptoms such as chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility. Early diagnosis and management have importance as endometriosis impairs the quality of life and creates a serious social and economic burden. There are different…

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Endometriosis and Progesterone Resistance

Endometriosis and Progesterone Resistance By Selma Oransay

Progesterone resistance is the unresponsiveness of endometrium with subsequent dysregulation of the progesterone signaling pathway, and endometrial gene works. Progestins, on the other hand, are the first-line treatment choice, especially for long-term treatment of endometriosis. In the clinics, one-third of…

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Headaches Appear Years Before a Diagnosis of Endometriosis

Headaches Appear Years Before a Diagnosis of Endometriosis By Özge Özkaya

Headache is associated with different forms of migraine, is related to pain, and often appears before diagnosis in women with endometriosis, according to a new study published in the scientific journal Reproductive Biomedicine Online. This knowledge can help ensure women with…

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Interleukin-35 expression in B lymphocytes: A new potential biomarker?

Interleukin-35 expression in B lymphocytes: A new potential biomarker? By Eylül GÜN

Regulatory T-cells (Tregs) and B-cells (Bregs) play a crucial role in establishing tolerance to self-antigens and suppressing immune activity. Therefore, in endometriosis, they are requisite for the endometriotic cells to survive outside the uterus. They suppress immune activity by producing…

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Unraveling the Role of Vascularization in Deep Endometriosis

Unraveling the Role of Vascularization in Deep Endometriosis By Bahar Yuksel

The systematic review by Simon G. Powell published in the journal Cells, analyzed 15 studies including 1125 women with deep infiltrative endometriosis up to March 2023 in several databases and found that angiogenesis plays a crucial role in the growth…

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Does ovarian endometrioma affect embryo aneuploidy rate in fertile women?

Does ovarian endometrioma affect embryo aneuploidy rate in fertile women? By Hale Goksever Celik

One of the most common clinical findings of women with endometriosis is the decline in fertility status. These women often benefit from in vitro fertilization methods to become pregnant. However, whether there is a detrimental effect of endometriosis on oocyte and…

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When to start ART after laparoscopic treatment of endometriosis?

When to start ART after laparoscopic treatment of endometriosis? By Selma Oransay

Laparoscopy combined with histopathologic confirmation of endometriosis is the reference standard for diagnosing endometriosis. Additionally, laparoscopic surgery is considered the most effective way to approach infertility induced by endometriosis. The surgical factors influencing the outcome of treating the infertility of…

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Nutritional recommendations for endometriosis patients

Nutritional recommendations for endometriosis patients By Eylül GÜN

Diet and lifestyle factors have been implicated in the development and progression of endometriosis, in addition to genetic determinants. Piecuch et al. from Poland conducted a review study discussing the importance of different nutrients and nutritional recommendations in endometriosis. The…

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Novel Diagnostic Strategies for the Detection of Malignant Transformation of Endometriosis

Novel Diagnostic Strategies for the Detection of Malignant Transformation of Endometriosis By Bahar Yuksel

Endometriotic implants can grow on various organs and tissues in the pelvis, leading to pain, infertility, and other symptoms. Most cases of endometriosis are benign and there is a small risk of malignant transformation. The review conducted by Dr. Hiroshi…

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Improving the quality of life: The role of cognitive behavioral therapy after endometriosis surgery

Improving the quality of life: The role of cognitive behavioral therapy after endometriosis surgery By Eylül GÜN

Endometriosis and its symptoms have been associated with poor mental health and reduced quality of life. Cognitive behavioral therapy is recognized as an effective psychological treatment for managing depression, anxiety, and stress. Although surgery for endometriosis improves a patient's quality…

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The effect of glucocorticoid use on clinical pregnancy rates

The effect of  glucocorticoid use on clinical pregnancy rates By Selma Oransay

The preference to use glucocorticoids such as dexamethasone, prednisone, and methylprednisolone, along with IVF-ET cycles is due to the diminishing inflammatory response and suppressing immunity. Thus, while autoimmune diseases are suppressed with glucocorticoid administration, the success rate in the implantation…

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A rare and challenging site for endometriosis: Pancreas

A rare and challenging site for endometriosis: Pancreas By Eylül GÜN

Pancreas presents as a rare site for extragenital endometriosis. Gkegkes et al. performed a systematic review of the literature on pancreatic endometriosis. The article was published in the Jan-Feb 2023 issue of the journal Annals of Gastroenterology. A comprehensive search…

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Pregnancy and Endometriosis: The Hidden Risk of Gestational Diabetes

Pregnancy and Endometriosis: The Hidden Risk of Gestational Diabetes By Bahar Yuksel

Getting pregnant with endometriosis may be challenging. Besides, that pregnancy is a high-risk pregnancy. According to the recent meta-analysis led by Dr.Vigano, the risk of gestational diabetes increases in endometriosis patients. The study performed database searches on PubMed, Medline, Embase, and…

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The cost-effectiveness of different GnRH agonist regimes for progestogen-resistant endometriosis.

The cost-effectiveness of different GnRH agonist regimes for progestogen-resistant endometriosis. By Selma Oransay

Surgical and medical treatments are currently used to treat the pelvic pain caused by endometriosis. Respected guidelines recommend using progestins with or without estrogens as first-line medical treatment due to their safety, effectiveness, inexpensive, and tolerability. However, one-third to one-quarter…

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The effect of dienogest vs ethynyl estradiol/dienogest on quality of life in women with endometriosis

The effect of dienogest vs ethynyl estradiol/dienogest on quality of life in women with endometriosis By Hale Goksever Celik

Women with endometriosis suffer from dysmenorrhea, dyspareunia, and chronic pelvic pain that diminishes the quality of their life. Both physical and mental components of quality of life have been affected by endometriosis-associated symptoms. There are several medical and surgical treatment…

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Exploring tissue origins and age characteristics in endometriosis

Exploring tissue origins and age characteristics in endometriosis By Eylül GÜN

Despite its widespread occurrence, the precise factors leading to endometriosis and the nature of its symptoms remain uncertain. To better understand the disease and improve treatment, Leap et al. from the US and Austria explored the use of DNA methylation…

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Exploring the Potential Impact of Prenatal Testosterone on Endometriosis

Exploring the Potential Impact of Prenatal Testosterone on Endometriosis By Bahar Yuksel

The exact causes of endometriosis still remain uncertain but emerging evidence suggests that prenatal factors may contribute to its development. In the review study by Bernard J Cresp et al, the authors discuss the hormonal environment during prenatal development and…

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Another New Approach Could Help Diagnose deep Infiltrating endometriosis

Another New Approach Could Help Diagnose deep Infiltrating endometriosis By Özge Özkaya

Elastography could help distinguish deep infiltrating endometriosis (DIE) nodules from non-endometriotic tissue at different locations, according to a new study published in Ultraschall in der Medizin - European Journal of Ultrasound. The potential of the technique in improving the diagnosis…

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The role of IL-33 and "T-regs" in lesion progression and fibrosis in endometriosis

The role of IL-33 and By Eylül GÜN

It has been recognized that immune regulation likely plays a crucial role in endometriosis. Regulatory T cells (Tregs) are important immune regulators, and studies have linked Tregs to endometriosis development through signaling pathways involving TGF-β1 and PDGF. IL-33, an inflammatory…

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Ultrasonographic findings predicting parametrial deep endometriosis

Ultrasonographic findings predicting parametrial deep endometriosis By Selma Oransay

Transvaginal ultrasonographic evaluation is the primary imaging technique to rule out deep endometriosis. Although the International Deep Endometriosis Analysis Group (IDEA) published a consensus to standardize the nomenclature of ultrasonographic pelvic examination in women with suspected deep endometriosis, parametrial deep endometriosis…

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Deep Infiltrating Endometriosis and Adenomyosis have different genetic pathways

 Deep Infiltrating Endometriosis and Adenomyosis have different genetic pathways By Bahar Yuksel

It is still not defined whether adenomyosis is also a deep endometriosis component or not. In the study conducted by Marshall et al, the researchers compared the gene expression patterns between deep infiltrating endometriosis (DIE) and adenomyosis uteri in order…

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Endometriosis diet and the quality of life

Endometriosis diet and the quality of life By Hale Goksever Celik

Women with endometriosis suffer mainly from pelvic pain which results in a negative effect on the quality of life. Although several treatment options have been proposed, some endometriosis patients still have poor quality of life due to pelvic pain. Upon…

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Surgery for Deep Endometriosis

Surgery for Deep Endometriosis By Selma Oransay

In recent years, minimally invasive surgery has gained popularity, providing the best results in gynecologic cancers and deeply infiltrated endometriosis. With the help of a high-definition camera displayed on a TV monitor, the small structures are enlarged 4-7 times and…

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Neuroendocrine pathway in endometriosis-related infertility

Neuroendocrine pathway in endometriosis-related infertility By Eylül GÜN

Dr. Robert Taylor from Jacobs School of Medicine, University at Buffalo presented on the newly defined neuroendocrine pathway and its role in endometriosis-related infertility and how implantation and pregnancy establishment might be disrupted in endometriosis at the Annual International Medical Conference of…

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Adenomyosis and infertility: Does immunology mapping help?

Adenomyosis and infertility: Does immunology mapping help? By Nasuhi Engin Aydin

Professor Dr. Wolfgang Küpker (MD, PhD), Medical Director and CEO of IVF Baden Baden at the University of Schleswig Holstein in Lübeck delivered a conference at the  Annual International Medical Conference of the Endometriosis Foundation of America held in New York on April…

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From inflammation to remission: The promising role of jun kinase inhibitors in endometriosis

From inflammation to remission: The promising role of jun kinase inhibitors in endometriosis By Eylül GÜN

Stephen Palmer from Baylor College of Medicine presented his speech at the Annual International Medical Conference of the Endometriosis Foundation of America held in New York on April 1-2, 2023. Dr. Palmer began his talk with a philosophy and a personal statement “Endometriosis is…

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​Modeling the feto-maternal interface using pluripotent stem cells

​Modeling the feto-maternal interface using pluripotent stem cells By Özge Özkaya

Researchers from Columbia University led by Dr. Mijo Simunovic created a model using which they can study the relationship between the developing human embryo and the endometrium. The findings were presented at the Annual International Medical Conference of the Endometriosis Foundation…

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The #Enzian classification, an essential tool for surgical management of severe endometriosis

The #Enzian classification, an essential tool for surgical management of severe endometriosis By Hale Goksever Celik

The lecture entitled "The #Enzian classification, an essential tool for surgical management of severe endometriosis" was presented by Professor. Jörg Keckstein, from the University Ulm, Germany, at the Annual International Medical Conference of the Endometriosis Foundation of America held in New York on…

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Endometriosis disease modelling via induced pluripotent stem cells has been successful

Endometriosis disease modelling via induced pluripotent stem cells has been successful By Nasuhi Engin Aydin

J. Julie Kim, S. Y. Hung Research Professor and Professor of ObGyn, Reproductive Science in Medicine, Northwestern University, Chicago, Illinois, has delivered a conference at the  Annual International Medical Conference of the Endometriosis Foundation of America held in New York on April 1-2,…

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​Insights into immune dysfunction in endometriosis - Chandrakant Tayade, DVM, PhD

​Insights into immune dysfunction in endometriosis - Chandrakant Tayade, DVM, PhD By Bahar Yuksel

In his speech presented at the Annual International Medical Conference of the Endometriosis Foundation of America held in New York on April 1-2, 2023, Dr. Tayade talks about the relationship between endometriosis and the immune system. Dr. Tayade begins by emphasizing the significance of…

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Which surgery for deep endometriosis? Laparoscopic shaving or rectal resection?

 Which surgery for deep endometriosis? Laparoscopic shaving or rectal resection? By Selma Oransay

This keynote lecture entitled "Deep endometriosis: The place of laparoscopic shaving" was presented by Dr. Jacques Donnez, the director of the infertility research unit at the Catholic University of Louvain, Brussels, Belgium, at the Annual International Medical Conference of the Endometriosis Foundation…

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Preclinical organ-on-chip models of endometriosis lesions - Linda Griffith, PhD

Preclinical organ-on-chip models of endometriosis lesions - Linda Griffith, PhD By Özge Özkaya

Professor Linda Griffith, Professor of Biological and Mechanical Engineering and the director of the Center for Gynepathology Research at Massachusetts Institute of Technology gave a presentation about their preclinical organ on-chip models of endometriosis lesions at the 14th Annual International…

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Epigenetic defects of stromal cells in endometriosis and adenomyosis lead to estrogen sensitivity

Epigenetic defects of stromal cells in endometriosis and adenomyosis lead to estrogen sensitivity By Nasuhi Engin Aydin

Serdar Bulun, MD, J.J. Sciarra Professor and Chair Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois has delivered a conference on “Endometriosis and adenomyosis: single-cell genome-wide approaches” at the Annual International Medical Conference of the Endometriosis Foundation…

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2023 MedicalConferance: Pros and cons of hormonal interventions for endometriosis - Sarah Berga, MD

2023 MedicalConferance: Pros and cons of hormonal interventions for endometriosis - Sarah Berga, MD By Bahar Yuksel

Prof. Berga, MD., who is the Chair of Ob&Gyn at Jacobs School Medicine and Biomed Sciences, presented this speech at the 2023 EFA Medical Conference. Dr. Berga explains that the primary goals of endometriosis treatment are to reduce pain and improve quality…

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Is there any advantage of addition of hysterectomy on deep endometriotic pelvic pain or on the quality of life?

Is there any advantage of addition of hysterectomy on deep endometriotic pelvic pain or on the quality of life?  By Selma Oransay

 The addition of hysterectomy and salpingo-oophorectomy to the endometriosis excision surgery provided greater benefits when compared to excision surgery alone, according to the results of a comparison study that was recently published in the journal named "Facts Views and Visions in Obstetrics…

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Stem cells could be a good choice for therapeutic steps in many gynecologic disorders, including endometriosis

Stem cells could be a good choice for therapeutic steps in many gynecologic disorders, including endometriosis By Nasuhi Engin Aydin

Dr. Liu from the First Hospital of Jilin University, China, and colleagues from China and the USA have published their comprehensive review on the therapeutic gateways of stem cells in female genital tract disorders in a recent issue of Life…

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A self-diagnostic tool that predicts the likelihood of endometriosis

A self-diagnostic tool that predicts the likelihood of endometriosis By Bahar Yuksel

Early diagnosis and treatment of endometriosis are crucial for preventing these negative outcomes, but the disease is often difficult to diagnose due to a lack of specific symptoms and reliable diagnostic tests. Goldstein et al. aimed to develop a machine-learning…

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 The relationship between p53 gene polymorphism and endometriosis

 The relationship between p53 gene polymorphism and endometriosis By Eylül GÜN

The p53 gene is a well-known tumor suppressor gene that plays a crucial role in preventing cancer by regulating cell growth and division. Recent studies suggest that the p53 gene may also be linked to endometriosis. To investigate the relationship…

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Anti-IL-8 antibody ameliorates inflammation and fibrosis: A promising treatment for endometriosis

Anti-IL-8 antibody ameliorates inflammation and fibrosis: A promising treatment for endometriosis By Eylül GÜN

Endometriosis is a condition associated with chronic inflammation and fibrosis, and there are limitations and side effects with current treatments such as hormonal therapy and surgery. Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP1) are inflammatory cytokines that play a crucial…

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Antioxidant astaxanthin has promising effects on endometriosis-related infertility.

Antioxidant astaxanthin has promising effects on endometriosis-related infertility. By Nasuhi Engin Aydin

Dr. Rostami and colleagues from the Tehran University of Medical Sciences, Iran, have published a pioneering clinical study on the effects of antioxidant astaxanthin supplementation in infertile endometriosis patients in the scientific journal named Frontiers in Endocrinology. A complicated network…

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Transvaginal Hydro laparoscopy for diagnosing and treatment of early stages of endometriosis

Transvaginal Hydro laparoscopy for diagnosing and treatment of early stages of endometriosis By Selma Oransay

Transvaginal hydro laparoscopy is a minimally invasive procedure that allows the exploration of the female pelvis. An obliterated Douglas pouch by a fixed retroverted uterus, an ovarian endometrioma greater than 2 cm, and the presence of deeply infiltrated endometriosis are…

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First-line surgery or first-line ART: A real challenge both for the clinicians and infertile women having DIE without colorectal involvement

First-line surgery or first-line ART: A real challenge both for the clinicians and infertile women having DIE without colorectal involvement By Hale Goksever Celik

Deep infiltrating endometriosis (DIE) is defined as the presence of endometriotic lesions over 5 mm in depth under the peritoneal surface. These women suffer from chronic pelvic pain, dysmenorrhea, dyspareunia, chronic pelvic pain, bloody or painful bowel movements, and infertility. There…

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Insights into the experiences of people with endometriosis during COVID-19 pandemic

Insights into the experiences of people with endometriosis during COVID-19 pandemic By Selma Oransay

During the isolation of Covid 19 pandemic period, the most critical issue was healthcare access for patients. This was worse for patients who had chronic illnesses. Endometriosis is one of these chronic illnesses that need regular care, pain relievers, and…

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Serum Galectin-9 : A promising marker for endometriosis diagnosis

Serum Galectin-9 : A promising marker for endometriosis diagnosis By Nasuhi Engin Aydin

Dr. Jarollahi and colleagues from Iran University of Medical Sciences, Tehran have published their research on serum levels of Galectin-9 as a noninvasive marker for endometriosis in the "Journal of Reproduction & Infertility". Endometriosis imposes a great challenge in the…

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Women With Chronic Pelvic Pain Have a Negative Experience With Doctors

Women With Chronic Pelvic Pain Have a Negative Experience With Doctors By Özge Özkaya

Women with chronic pelvic pain have a negative experience with the healthcare system, according to a study by US researchers published in the International Journal of Obstetrics and Gynecology. This is the case regardless of whether or not they have…

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The enhanced invasiveness, migration and the development of adenomyosis: Importance of M2 macrophages

The enhanced invasiveness, migration and the development of adenomyosis: Importance of M2 macrophages By Hale Goksever Celik

Adenomyosis is the ectopic presence of endometrial stromal and glandular cells inside the myometrial tissue. Adenomyosis is diagnosed in women with gynecological problems with an incidence of 20%, although it is encountered much more frequently in hysterectomy specimens. Among many…

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Does Endometriosis Surgery Increase the Rate of Pregnancy?

Does Endometriosis Surgery Increase the Rate of Pregnancy? By Özge Özkaya

Surgery to treat colorectal endometriosis leads to a high rate of pregnancy following the operation, found a new study published in the Journal of Minimally Invasive Gynecology. The authors of the study said, “studies with a high level of evidence…

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Histopathologic examination always has the final word in tubal endometriosis

Histopathologic examination always has the final word in tubal endometriosis By Nasuhi Engin Aydin

Hai-Ning Jiao and coworkers from the Department of Obstetrics and Gynecology of Shanghai Jiao Tong University School of Medicine, China, reported the salient features of 30 tubal endometriosis cases in the World Journal of Clinical Cases. Tubal endometriosis is characterized…

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New adapted ESHRE guidelines for endometriosis.

New adapted ESHRE guidelines for endometriosis. By Selma Oransay

Eun Hee Yu and Jong Kil Joo from the Department of Obstetrics and Gynecology of Pusan National University School of Medicine, Republic of Korea, published a commentary on the 2022 ESHRE guidelines, referring to the representative changes and important updates in a recently…

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A Multidisciplinary Surgical Team Is a Must in Deep Endometriosis Surgery

A Multidisciplinary Surgical Team Is a Must in Deep Endometriosis Surgery By Özge Özkaya

Endometriosis must be managed by a team of multidisciplniary specialists, especially in case it causes damage to the digestive tract, according to a new study published in the journal Archives of Gynecology and Obstetrics. According to the authors, the presence…

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A review of multimodal imaging modalities for endometriosis.

A review of multimodal imaging modalities for endometriosis. By Selma Oransay

Since there is a lack of non-invasive biomarkers to diagnose endometriosis clinically, imaging techniques such as transvaginal ultrasonography and MRI have significant importance in preoperative endometriosis diagnosis. These imaging techniques allow appropriate surgical planning before laparoscopic excision, especially in deeply…

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Antiinflammatory lactoferrin molecule and antibody levels in endometriosis patients

Antiinflammatory lactoferrin molecule and antibody levels in endometriosis patients By Nasuhi Engin Aydin

A Japanese clinical research team led by Dr. Kaya Mori-Yamanaka from Shiga University of Medical Science Hospital, Otsu, Shiga, Japan, published their pioneering study on the role of serum lactoferrin and anti-lactoferrin antibody levels in endometriosis in a recent issue of…

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Importance of dynamic cystoscopy for bladder endometriosis.

Importance of dynamic cystoscopy for bladder endometriosis. By Bahar Yuksel

Bladder endometriosis is a rare type of endometriosis but when diagnosed it requires extensive surgical procedures which include bladder resections. Thus, diagnosis and proper treatment are vital. In the study conducted in Brazil, the authors questioned the accuracy of applying…

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Laparoscopic resection of bladder endometriosis

 Laparoscopic resection of bladder endometriosis By Selma Oransay

When we talk about deep-infiltrating endometriosis, one of the most commonly affected organs in the urinary tract is the bladder, with a prevalence of 80%. Bladder endometriosis can be defined as the existence of the endometrial glands and stroma inside…

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Current AAGL Staging System Not Good at Predicting Complexity of Endometriosis Surgery

Current AAGL Staging System Not Good at Predicting Complexity of Endometriosis Surgery By Özge Özkaya

The link between the stage of endometriosis as defined by the American Association of Gynecologic Laparoscopists (AAGL) and the level of surgical complexity is weak or moderate, according to a new study published in the Journal of Minimally Invasive Gynecology. …

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Postoperative pregnancy outcomes in women with deep infiltrating endometriosis

Postoperative pregnancy outcomes in women with deep infiltrating endometriosis By Hale Goksever Celik

Subperitoneal invasion of endometriotic lesions exceeding 5 mm in depth is named "deep infiltrating endometriosis' and can be located on uterosacral ligaments, in the intestine, vagina, bladder, and ureter. Women with deep infiltrating endometriosis suffer from pelvic pain and infertility most…

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This time it is good to have this stress: Endoplasmic reticulum stress and endometriosis.

This time it is good to have this stress: Endoplasmic reticulum stress and endometriosis. By Bahar Yuksel

Endometriosis is a hormone-based inflammatory disease. Cell-level therapeutic options are very popular when resistance to cell death capacity of endometriotic cells is on the table. In the review conducted by Hussein Riyadh Abdul Kareem Al‑Hetty et al, the authors summarized…

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Comparison of two surgical approaches for endometriosis.

Comparison of two surgical approaches for endometriosis. By Selma Oransay

Endometriosis is one of the causes of infertility in women. But the pathophysiology of infertility caused by endometriosis is not yet clear. Hormonal disorders, abnormal peritoneal function, distorted pelvic anatomy, and multiple cesarean deliveries are among the accused.  Dr. Li…

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Is there a way for a nonaddictive opioid for endometriosis pain?

Is there a way for a nonaddictive opioid for endometriosis pain? By Bahar Yuksel

Endometriosis is a neuro-inflammatory disease whose current medical treatment is hormonal therapy. Given the side effects and the possible interactions between the opioid system and pain mechanisms, a new opioid medication might be promising. in the review conducted by Dr.Mechsner et…

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From Finland : How to increase health issues in endometriosis patients

From Finland : How to increase health issues in endometriosis patients By Nasuhi Engin Aydin

Dr. Henna-Riikka Rossi and associates from the University of Oulu, Oulu, Finland have published their recent prospective cohort study on possible existing comorbidities of endometriosis patients in the journal Fertility and Sterility. Endometriosis is an estrogen-dependent chronic ailment affecting about…

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Endometriosis awarness for the Gastroenterologists.

Endometriosis awarness for the Gastroenterologists. By Selma Oransay

Women with endometriosis can develop chronic abdominal pain and/or abnormal bowel habits more than eight times compared to women without endometriosis. For this reason, an undiagnosed patient with endometriosis may be referred to a gastroenterologist and remain in a situation…

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Comparison of different IVF stimulation protocols for pregnancy success in infertile endometriosis patients

Comparison of different IVF stimulation protocols for pregnancy success in infertile endometriosis patients By Hale Goksever Celik

Women with endometriosis may suffer from reproductive problems up to an incidence of 50%. Several pathophysiological mechanisms including anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis and sperm movements are the most responsible for the development of endometriosis-associated infertility.…

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Is alcohol a risk factor for endometriosis?

Is alcohol a risk factor for endometriosis? By Eylül GÜN

As complex and unclear as endometriosis pathogenesis is, the influence of environmental factors on the inflammation that underlies the pathogenesis of endometriosis has been thoroughly investigated. Lifestyle factors such as diet, caffeine, environment, smoking, and alcohol consumption have been explored…

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Hypoxia and endometriosis: A review of mechanisms

Hypoxia and endometriosis: A review of mechanisms By Eylül GÜN

Various mechanisms have been suggested to explain the development of endometriosis lesions. One of these is hypoxia, which can induce changes in endometrial cells, but the exact mechanism is not yet clear. Zhou et al from China wrote a review…

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Is the pathogenesis of endometriosis hidden in immune-related gene profiles ?

Is the pathogenesis of endometriosis hidden in immune-related gene profiles ? By Nasuhi Engin Aydin

Yanan He and colleagues from the Department of Gynecology, Harbin Medical University, China  have published their manuscript on potential immune markers in endometriosis in a recent issue of  “Journal of Immunology Research” Pathophysiologic mechanisms involving endometriosis are complicated and have…

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GnRH Antagonists Can Effectively Reduce Endometriosis Pain

GnRH Antagonists Can Effectively Reduce Endometriosis Pain By Özge Özkaya

Oral gonadotropin-releasing hormone (GnRH) antagonists are effective in reducing pain associated with endometriosis in 12 weeks, according to a new study published in the scientific journal Archives of Gynecology and Obstetrics. The safety and efficacy of most drugs were dose-dependent…

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The effectiveness of acupuncture in the treatment of dysmenorrrhea

The effectiveness of acupuncture in the treatment of dysmenorrrhea By Selma Oransay

Asymptomatic endometriosis does not adversely affect women's quality of life and mental health. But the quality of life of women with endometriosis who suffer endometriosis-related pelvic pain, dysmenorrhea, dyspareunia, and dysuria declines as they become more susceptible to anxiety and…

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Activities of cytotoxic cells in endometriosis

Activities of cytotoxic cells in endometriosis By Eylül GÜN

Immunological dysfunction is thought to be involved in the etiopathogenesis of endometriosis, leading to defective immunosurveillance and the growth of endometriotic lesions. In this pathway, reduced cytotoxicity of peripheral and peritoneal natural killer (NK) cells is seen as a contributing…

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Conventional IVF or ICSI: Which one is more accurate in endometriosis-related infertility?

Conventional IVF or ICSI: Which one is more accurate in endometriosis-related infertility? By Hale Goksever Celik

Although the prevalence of endometriosis is 10-15% in the general population at reproductive age, it is diagnosed more frequently in infertile women with a prevalence of 25-40%. Although the exact mechanism explaining the association between endometriosis and infertility has not…

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The optimal endometrial preparation protocol in FET cycles of women with endometriosis.

The optimal endometrial preparation protocol in FET cycles of women with endometriosis. By Selma Oransay

Endometriosis can create infertility and may require treatment with assisted reproductive technology (ART) to induce pregnancy. However, the current literature rarely discusses the optimal endometrial preparation protocol in thawed-frozen embryo transfer (FET) cycles for endometriotic patients. Dr.Jin. group from the Reproductive…

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How Can Endometriosis Care Be Improved?

How Can Endometriosis Care Be Improved? By Özge Özkaya

Researchers identified 61 areas for improvement in endometriosis care based on the answers of endometriosis patients. Of these the top five areas of improvement were to train caregivers in order to develop their knowledge about endometriosis, to provide better management…

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Evaluation of the postoperative disability in women with endometriosis.

 Evaluation of the postoperative disability in women with endometriosis. By Selma Oransay

Endometriosis is a chronic disease with a prevalence of 4,4% in women of reproductive age. It is also estimated that 23,8 of infertile women have endometriosis. Pelvic pain, dyschezia, dysmenorrhea, and dysuria are the symptoms of this disease that negatively…

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The most common gynecologic admissions to the emergency: Endometriosis and adenomyosis

The most common gynecologic admissions to the emergency: Endometriosis and adenomyosis By Hale Goksever Celik

Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Adenomyosis occurs when the endometrial glandular and stromal tissue grows into the muscular wall of the uterus, called the myometrium. Women having adenomyosis also…

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The emotions and experiences of women with endometriosis during and after pregnancy

The emotions and experiences of women with endometriosis during and after pregnancy By Eylül GÜN

It is well-known that endometriosis patients have a high rate of infertility and a hard time getting pregnant compared to women without endometriosis. Despite the belief that pregnancy can alleviate endometriosis symptoms, some studies have shown that women with endometriosis…

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Relation between hormone replacement therapy and postmenopausal endometriosis.

Relation between hormone replacement therapy and postmenopausal endometriosis. By Bahar Yuksel

The faith of endometriosis after oophorectomy with hysterectomy is unknown. It is clear that applying only a hysterectomy but leaving the affected tissue behind is not a solution for endometriosis-related symptoms. Either total clearance or leaving endometriotic tissues behind when…

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Endometriosis Seems to Increase the Risk of Preeclampsia

Endometriosis Seems to Increase the Risk of Preeclampsia By Özge Özkaya

Women with endometriosis who conceive spontaneously, i.e. without the help of assisted reproductive technologies seem to be at a higher risk of preeclampsia, according to a new study published in the Journal of Minimally Invasive Gynecology. However, endometriosis does not…

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Economic burden while living with endometriosis.

Economic burden while living with endometriosis. By Bahar Yuksel

Endometriosis is a debilitating disease when all the symptoms are considered. Besides mental and physical effects, the economic burden is also a problem for the patients. In the study conducted by Josep Darbà et al, the costs of endometriosis have…

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Diaphragmatic Endometriosis: a Call for Awareness

Diaphragmatic Endometriosis: a Call for Awareness By Nasuhi Engin Aydin

Dr. Pagano and colleagues from the Department of Gynecology and Obstetrics, University of Bern, Switzerland, have published a prospective cohort study on diaphragmatic involvement in endometriosis patients in a recent issue of “The Journal of Minimally Invasive Gynecology”. Endometriosis is…

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Iron and toxic environmental elements in ovarian endometriomas

Iron and toxic environmental elements in ovarian endometriomas By Selma Oransay

It is well-known that the growth of endometriotic lesions is estrogen-dependent and supported by inflammatory processes. In addition to oxidative stress, it is believed that several other factors, including chemicals and environmental factors, and genetic predisposition may play a potential…

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Women With More Severe Endometriosis Have Fewer Eggs

Women With More Severe Endometriosis Have Fewer Eggs By Özge Özkaya

Severe endometriosis negatively affects ovarian response and the quality of oocytes and embryos, according to a new study published in JBRA Assisted Reproduction. However, the rate of fertilization does not seem to be affected by endometriosis stage.  These findings could…

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Endometriosis-Associated Pain: The Role of Sensitization

Endometriosis-Associated Pain: The Role of Sensitization By Eylül GÜN

As the most common symptom of the disease, endometriosis-associated pain (EAP) is experienced as dysmenorrhea, non-cyclical pelvic pain, and cyclical pain related to organ function. EAP is contributed to by different mechanisms, including local factors, peripheral sensitization, central sensitization, cross-sensitization,…

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Ultrasonographic Presurgical Staging and Classification of Endometriosis

 Ultrasonographic Presurgical Staging and Classification of Endometriosis By Selma Oransay

Laparoscopic surgery is the gold standard for diagnosing endometriosis, but a preoperative imaging procedure is strongly recommended. Transvaginal sonography by a skilled examiner is not inferior to MRI diagnostics regarding sensitivity and specificity in predicting the extension of deep endometriosis.  …

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Molecular Alterations in Ovarian Endometriosis

Molecular Alterations in Ovarian Endometriosis By Elisabetta Kuhn

Endometriosis is a benign disease with biological features characteristic of malignant tumors, such as invasiveness and migration abilities. In epithelial malignant tumors, it is believed that epithelial-mesenchymal transition (EMT), that is, the switch of an epithelial phenotype versus a mesenchymal…

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Sexual function in infertile women with PCOS and endometriosis

Sexual function in infertile women with PCOS and endometriosis By Hale Goksever Celik

Women with endometriosis suffer from several symptoms and signs including dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility which have a detrimental effect on their quality of life. Sexual dysfunction also is a common problem for endometriosis patients due to complex…

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Transvaginal ultrasound or MRI for retroflexed uterus in endometriosis

Transvaginal ultrasound or MRI for retroflexed uterus in endometriosis By Nasuhi Engin Aydin

Dr Matsuda and colleagues from the Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan have published their study evaluating the effectiveness of transvaginal ultrasound on the diagnosis of uterine retroflexion in a recent issue of “Journal of Nippon…

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Imaging techniques for fallopian tubes

Imaging techniques for fallopian tubes By Selma Oransay

The imaging techniques used for suspected fallopian tube pathology are ultrasound, hysterosalpingo-contrast-sonography, hysterosalpingography, computed tomography, and magnetic resonance imaging. Among several benign lesions that involve fallopian tubes, pelvic inflammatory disease, tubo-ovarian abscess, salpingitis isthmica nodosa, hydrosalpinx, tubal endometriosis, isolated fallopian…

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Do not underestimate the power of red blood cell evaluation in endometriosis

Do not underestimate the power of red blood cell evaluation in endometriosis By Eylül GÜN

In an effort to develop an easy-to-use diagnostic marker, research has focused on the pro-inflammatory nature of endometriosis and the raised levels of inflammatory markers. The neutrophil-to-lymphocyte ratio (NLR) has emerged as one of these markers. Moreover, endometriosis has been…

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Gastrointestinal symptoms in colorectal deep endometriosis

Gastrointestinal symptoms in colorectal deep endometriosis By Eylül GÜN

The colon, particularly the recto-sigmoid is the most commonly involved area in deep endometriosis. These patients suffer from gastrointestinal symptoms almost as much as pelvic pain symptoms the most common being reported as frequent and painful defecation. Gastrointestinal symptoms may…

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Diagnostic criteria for uterosacral ligament involvement in endometriosis.

Diagnostic criteria for uterosacral ligament involvement in endometriosis. By Selma Oransay

Transvaginal ultrasonography is often used to diagnose endometriosis in suspected women due to its high resolution, low cost, and relatively low discomfort. Histologic confirmation of laparoscopically removed specimens is still the gold standard for appropriate diagnosis.  The team led by…

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Scientific unfolding will lead new drug targets

Scientific unfolding will lead new drug targets By Nasuhi Engin Aydin

Drs. Dolmans and Donnez from academic institutions located in Brussels, Belgium, have published their comprehensive review on the current pathophysiological concepts in endometriosis with possible drug treatment potentials in the recent issue of a scientific journal named “Biomolecules”.  As a…

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The "Painful Periods Screening Tool" Could Speed Endometriosis Diagnosis

The By Özge Özkaya

The Painful Periods Screening Tool (PPST) is a useful tool for women with endometriosis, according to a new study published in the scientific journal Reproductive Sciences. The study's authors said that the tool “ facilitated communication between patients and providers…

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Endometriosis and the body perception

Endometriosis and the body perception By Hale Goksever Celik

The most common endometriosis-associated symptoms are pelvic pain, dysmenorrhea, dyspareunia, and infertility. Women with endometriosis should be managed due to the significant impact of these symptoms on their quality of life. Body perceptions of these women are also affected depending…

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 Adverse pregnancy outcomes and endometriosis.

 Adverse pregnancy outcomes and endometriosis. By Selma Oransay

Inflammation plays a big role in the pathogenesis of endometriosis with the release of inflammatory cytokines, angiogenic imbalance, and oxidative stress. These pathways are also common features of severe maternal morbidity. Severe maternal morbidity is life-threatening, causing cardiac and renal…

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Creating a reliable indirect immunofluorescence protocol as a promising diagnostic tool for endometriosis

Creating a reliable indirect immunofluorescence protocol as a promising diagnostic tool for endometriosis By Eylül GÜN

Owing to its inflammatory nature, endometriosis results in the overproduction of reactive oxygen species (ROS) which disrupt the cellular functions and eventually lead the cell to apoptosis and cell cycle arrest. Senescence, the natural state of irreversible cell cycle arrest,…

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Uterine leiomyomas and endometriosis may coexist yielding important clinical implications

Uterine leiomyomas and endometriosis may coexist yielding important clinical implications By Nasuhi Engin Aydin

Drs. Uimari, Nazri, and Tapmeier from Finland, the UK, and Australia have published their comprehensive review on the comorbidity of endometriosis along with uterine leiomyomas in the medical journal  “Frontiers in Reproductive Health”.  The comorbidity of uterine leiomyomas and endometriosis…

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Rare but important entity: perineal endometriosis

Rare but important entity: perineal endometriosis By Nasuhi Engin Aydin

Dr. Zhu and colleagues from Peking Union Medical College Hospital have published their retrospective research on "surgically treated perineal endometriosis cases" in a recent issue of BMC’s Women’s Health. Perineal endometriosis is a rare type of endometriosis accounting for at…

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Gestrinone May Be Safe and Effective in Treating Endometriosis Symptoms

Gestrinone May Be Safe and Effective in Treating Endometriosis Symptoms By Özge Özkaya

Gestrinone seems to be safe for the treatment of endometriosis, according to a new study published in the scientific journal Archives of Gynecology and Obstetrics. It also may be more effective than danazol and other medical treatments.  However, these findings…

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Molecular and cellular mechanisms of fibrogenesis in endometriosis

Molecular and cellular mechanisms of fibrogenesis in endometriosis By Selma Oransay

Endometriosis lesions are characterized by endometrium-like cell proliferation, invasion, and oxidative stress associated with inflammation and neoangiogenesis. Fibrosis, which occurs due to these events, causes chronic pelvic pain depending on the location and the severity of endometriosis. For the purpose…

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 How accurate is ultrasonography in evaluating deep infiltrating endometriosis?

 How accurate is ultrasonography in evaluating deep infiltrating endometriosis? By Eylül GÜN

Deep infiltrating endometriosis (DIE) appears to be the most severe form of endometriosis comprising 15-30% of all endometriosis patients. The difference in the presentation of the lesions ranges from simple adhesions to infiltrative nodules. Even though there is no consensus…

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Do combination GnRH antagonists improve endometriosis-associated pain?

Do combination GnRH antagonists improve endometriosis-associated pain? By Hale Goksever Celik

Endometriosis is a chronic inflammatory disease with a broad spectrum of pain symptoms such as dysmenorrhea, dyspareunia, and chronic pelvic pain. It has been understood in light of scientific evidence that endometriosis results in diminished quality of life in these…

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Which parameter is useful in predicting cardiovascular disease risk in perimenopausal endometriosis patients?

Which parameter is useful in predicting cardiovascular disease risk in perimenopausal endometriosis patients? By Eylül GÜN

Cardiovascular disease is known to be the leading cause of death among women worldwide. Studies have shown that postmenopausal women are at a greater risk as well as women who undergo premature menopause proving the effect of hormonal imbalances on…

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Ovarian endometriomas, ovarian reserve, oocyte quality and IVF/ICSI outcomes

 Ovarian endometriomas, ovarian reserve, oocyte quality and IVF/ICSI outcomes By Selma Oransay

Surgery and assisted reproductive technology (ART) are the preferred treatments for endometrioma in infertile patients. When ART is considered, surgery may seem to have no advantages, as it may not improve pregnancy outcomes and may carry the risk of decreasing…

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Deep Endometriosis Surgery and Women’s Quality of Life

Deep Endometriosis Surgery and Women’s Quality of Life By Özge Özkaya

The physical and social functions as well as the overall physical health is worse than normal among Spanish women who underwent surgery for deep endometriosis, reported a new study published in the Journal of Clinical Medicine. The bodily pain, emotional…

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Uterine agenesis patients may have endometriosis too

Uterine agenesis patients may have endometriosis too By Nasuhi Engin Aydin

Dr. Steinmacher and colleagues at the Tuebingen University Hospital, Germany have published their unique study on a series of patients with congenital Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome in a recent issue of the “Journal of Clinical Medicine”. The absence uterus and upper…

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Minimally Invasive Surgery Improves the Quality of Life of Women With Deep Infiltrating Endometriosis

Minimally Invasive Surgery Improves the Quality of Life of Women With Deep Infiltrating Endometriosis By Özge Özkaya

Minimally invasive surgery improves the quality of life of women with deep infiltrating endometriosis two years after the operation, according to a new study published in the Journal of Clinical Medicine. The results are similar between conservative and total surgery.…

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Breastfeeding Seems to Protect Both Mother and Baby From Endo

Breastfeeding Seems to Protect Both Mother and Baby From Endo By Özge Özkaya

Breastfeeding seems to decrease the risk of endometriosis, according to a new study published in the scientific journal Breastfeeding Medicine. Similarly, there seems to be a negative association between ingesting breast milk and the risk of developing endometriosis later in…

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Efficacy of Uterine Artery Blockage in Endometriosis Management

Efficacy of Uterine Artery Blockage in Endometriosis Management By Nasuhi Engin Aydin

Dr. Li Ma and associates from Liaoning, China have published their results of a computerized database search on the role of uterine artery embolization in endometriosis in a recent issue of the periodical “Computational Intelligence and Neuroscience”. Currently, the management…

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Opioid use following operation for endometriosis or pelvic pain

Opioid use following operation for endometriosis or pelvic pain By Hale Goksever Celik

Women with endometriosis have pain in the form of dysmenorrhea, dyspareunia, and chronic pelvic pain, and they have a diminished quality of life depending on the severity of pelvic pain. Opioids have been preferred in many patients suffering from pain,…

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What causes pelvic pain? Androgens or estrogens?

What causes pelvic pain? Androgens or estrogens? By Selma Oransay

A comparison between women and men reveals that women suffer more pelvic pain. This reality raises the possibility of the pain-relieving effect of testosterone or androgens. It would be a wise solution to investigate how androgens affect pain at different…

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Endometriosis Hospitalization Trends in Spain

Endometriosis Hospitalization Trends in Spain By Eylül GÜN

According to the general assumption, one in every ten women is believed to have endometriosis. However, recent literature shows a big difference in the prevalence rates ranging from 1 to 5%, likely because most cases remain undiagnosed. The need for…

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Anhedonia and its relation to endometriosis as a sole symptom

Anhedonia and its relation to endometriosis as a sole symptom By Eylül GÜN

"Anhedonia may be defined as a broad category of hedonic function deficiencies, including diminished motivation or enjoyment capacity. It has been an area of interest for a long time in psychiatric disorders and has been crucial in some diagnoses such…

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Obstetric Outcomes of Pre-pregnancy Endometriosis Surgery

Obstetric Outcomes of Pre-pregnancy Endometriosis Surgery By Selma Oransay

Endometriosis may be associated with poor pregnancy outcomes, including placenta praevia, preterm birth, premature prelabour rupture of membranes, obstetric hemorrhage, gestational hypertensive disorders, fetal growth restriction, and perinatal death. Some authors have attempted to demonstrate a causal relationship between endometriosis…

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Foreseeing what will be seen on laparoscopy

Foreseeing what will be seen on laparoscopy By Bahar Yuksel

Endometriosis diagnosis still relies on preoperative prediction and its confirmation by taking biopsies. Thus, a prediction model for forecasting what would be waiting for the surgeon and the patient will be promising to get prepared.   In the study conducted…

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Scientists Try to Understand Consequences of Genetic Changes in Endometriosis

Scientists Try to Understand Consequences of Genetic Changes in Endometriosis By Özge Özkaya

The protocol of the "Endometriosis Research Queensland Study" has been published in the scientific journal BMJ Open. The aim of the study is to collect endometrial tissue associated with the disease and chart its genetic architecture. This way, the researchers aim to…

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Antimicrobial agent ornidazole yields promising effects in an animal model of endometriosis

Antimicrobial agent ornidazole yields promising effects in an animal model of endometriosis By Nasuhi Engin Aydin

Xiaoduo Qin and collaborators from Chinese medical centers, have published their results on the role of ornidazole using an experimental rat model in a recent issue of the periodical “Gynecologic and Obstetric Investigation”. Progression of endometriotic foci depends on the presence…

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The Delay in Endometriosis Diagnosis Is Huge

The Delay in Endometriosis Diagnosis Is Huge By Özge Özkaya

Eleven years pass on average in Italy for a woman to get diagnosed with endometriosis from when she starts having symptoms. This delay can even be even longer (4 more years) if the symptoms appear before a woman is age 20.…

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Non-hormonal medication for endometriosis-associated pelvic pain

 Non-hormonal medication for endometriosis-associated pelvic pain By Selma Oransay

The thought of benefiting from non-hormonal therapy in endometriosis pain is based on the pathophysiological findings that include angiogenesis, fibrosis, the presence of inflammatory cytokines and immune cells, apoptosis, and stem cell theory. But the effect of this treatment in…

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Epigenetic changes in endometriosis: A new target area for therapy

Epigenetic changes in endometriosis: A new target area for therapy By Eylül GÜN

Epigenetics is the heritable genetic modifications and changes in chromosomes without alterations in the DNA sequence. Numerous mechanisms, like DNA methylation and RNA editing to mention a couple, have been discovered as epigenetic alterations that are triggered by environmental factors.…

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Embryo implantation and endometriosis

Embryo implantation and endometriosis By Bahar Yuksel

Infertility is one of the main symptoms of endometriosis. And unfortunately, monthly fecundity rates decrease from 15% to 2-10% for women with endometriosis. The reason for these decreases is controversial and still not known whether it is because of impaired…

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Does endometrioma size have an effect on IVF/ICSI outcomes?

Does endometrioma size have an effect on IVF/ICSI outcomes? By Hale Goksever Celik

Assisted reproductive technologies including IVF/ICSI can be suggested as the therapeutic option in women with endometriosis-associated infertility. In literature, there is a controversy regarding the influence of endometrioma size on IVF/ICSI outcomes. The group led by Drs Chapron and Santoulli…

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Endometriosis Care Is More Patient-Centered for age older than 35

Endometriosis Care Is More Patient-Centered for age older than 35 By Özge Özkaya

Women younger than age 35 receive endometriosis care in a less patient-centered manner compared to older women, found a new study published in the Journal of Obstetrics and Gynecology. This finding underscores the importance of improving endometriosis care, especially for…

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Deep lateral parametrial endometriosis nerve-sparing surgery 

Deep lateral parametrial endometriosis nerve-sparing surgery  By Selma Oransay

Dr. Kanno et al. from the Department of Obstetrics and Gynecology of Kurashiki medical center, Okayama, Japan recently published a deep lateral parametrial endometriosis case report in the journal named Fertility and Sterility. The aim is to demonstrate the technical and…

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Devilish triad: Endometriosis-irritable bowel syndrome and eating disorders

Devilish triad: Endometriosis-irritable bowel syndrome and eating disorders By Bahar Yuksel

Most women with endometriosis report digestive symptoms. But it is not well-defined whether those are related to endometriosis itself or a secondary syndrome may be the cause. Irritable bowel syndrome, eating disorders, and anxiety are very commonly diagnosed diseases among women…

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TSH receptor antibodies show promising results in the diagnostic workup of endometriosis

TSH receptor antibodies show promising results in the diagnostic workup of endometriosis By Nasuhi Engin Aydin

Dr. Svensson with collaborators from the Swedish Lund University has published their results on the possible role of TSH receptor antibodies as biomarkers in endometriosis diagnosis in a recent issue of “European Journal of Obstetrics & Gynecology and Reproductive Biology”.…

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How beneficial is colorectal surgery for patients with deep endometriosis?

How beneficial is colorectal surgery for patients with deep endometriosis? By Eylül GÜN

In cases of deep endometriosis, which causes more severe pain and gastrointestinal symptoms, the patient's quality of life and fertility outcomes are negatively affected. Surgical intervention is thought to be the optimal treatment method in colorectal deep endometriosis cases, however,…

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Postoperative serum markers to predict serum AMH recovery following endometriosis surgery

Postoperative serum markers to predict  serum AMH recovery following endometriosis surgery By Hale Goksever Celik

Women with endometriosis seek treatment including ovarian cystectomy, because of symptoms that reduce their quality of life. Ovarian cystectomy using laparoscopic or robotic devices is the preferred therapy. However, it has been shown in the literature that ovarian reserve is…

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Web-based resource to improve menstrual health awareness

Web-based resource to improve menstrual health awareness By Selma Oransay

Many women consider "menstrual pain" a normal part of being female, and do not seek medical help but rather use self-management methods such as heat, rest, and analgesics. They are often unsure which self-management strategies are effective or what the…

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Exposure to toxic metals and the risk of endometriosis

Exposure to toxic metals and the risk of endometriosis By Selma Oransay

Mercury, lead, and cadmium are the best-studied heavy metals for several adverse effects on the human reproductive system. Mercury can induce DNA damage, oxidative stress, and mitochondrial dysfunction, and lead exposure is associated with menstrual disorders, preterm birth, and miscarriage.…

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Time to change out taboos about the radiologic evaluation of scar endometriosis

Time to change out taboos about the radiologic evaluation of scar endometriosis By Bahar Yuksel

Scar endometriosis is one of the rare forms of endometriosis. According to traditional belief, it has always been evaluated radiologically on menstruation days. In the study conducted by Balaban et al, the authors compared the differences in lesions according to…

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The management of diaphragmatic endometriosis

The management of diaphragmatic endometriosis By Selma Oransay

Thoracic endometriosis is a rare disease, and it is likely to have been underdiagnosed and underreported. Optimal diagnostic testing and management options are yet to be determined. Imaging for thoracic endometriosis is still in its infancy, and MRI only helps to…

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Understanding what we see: endometriosis laparoscopic appearance and microscopic verification

Understanding what we see: endometriosis laparoscopic appearance and microscopic verification By Nasuhi Engin Aydin

Chia-Sui Weng and colleagues from the Mayo Clinic, USA have published their results on laparoscopic appearances and microscopy of endometriotic lesions in “The Journal of Minimally Invasive Gynecology”. Even though the diagnosis of endometriosis has evolved greatly with advanced imaging…

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Rhein usage in endometriosis: A potential new therapeutic agent

Rhein usage in endometriosis: A potential new therapeutic agent By Eylül GÜN

The invasive nature of endometriosis has prompted scientists to find preventative and curative methods.  The progression and proliferation of endometriotic lesions are being studied extensively. As one of the agents used in Chinese herbal medicine for inflammatory disorders, rhein is…

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Endometriosis and the possible mechanisms of pain.

 Endometriosis and the possible mechanisms of pain. By Selma Oransay

The most common clinical symptoms of endometriosis are chronic pelvic pain and infertility. It is often not enough to treat pain symptoms with hormonal therapy or a surgical approach. Moreover, the stage of endometriosis has weakly associated with the amount,…

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Organizing structural protein Ezrin and its active form in endometriosis biopsies

Organizing structural protein Ezrin and its active form in endometriosis biopsies By Nasuhi Engin Aydin

Dr. Alessandra Peloggia and colleagues from Brazil have published their results on immunostaining of Ezrin protein and its phosphorylated active form in endometrial tissues in a recent issue of “Clinics” Possible factors on endometrial cell implantation and proliferation in the…

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Endometriosis and the cumulative live birth rate in IVF cycles.

Endometriosis and the cumulative live birth rate in IVF cycles.  By Hale Goksever Celik

Infertility is one of the symptoms encountered in up to 40-50% of women with endometriosis. There are several pathophysiological theories suggesting the development of endometriosis-associated infertility. Assisted reproductive technology (ART) using in vitro fertilization and embryo transfer (IVF-ET) has been…

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Taller Girls More Likely to Have Recurring Endometriosis

Taller Girls More Likely to Have Recurring Endometriosis By Özge Özkaya

Adolescents who are taller and have three or more lesions are at a higher risk of endometriosis recurrence following surgery, according to a new study by Chinese researchers published in the Journal of Obstetrics and Gynaecology. They should, therefore, be…

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The dilemma of autophagy and its role in endometriosis

The dilemma of autophagy and its role in endometriosis By Eylül GÜN

Autophagy is a mechanism for cell survival under metabolic stress that involves the degradation and recycling of intracellular components. Multiple genes actively control this process. Among these, the initiation stage of autophagosome formation is regulated by the gene Beclin-1 and…

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Endometriosis and Body Image

Endometriosis and Body Image By Özge Özkaya

Endometriosis has a negative effect on health-related quality of life and body familiarity according to a new study published in the Journal of Psychosomatic Research. Based on this finding, the authors of the study recommend that body familiarity should be…

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A prediction model to identify endometriosis during routine ultrasound .

A prediction model to identify endometriosis during routine ultrasound . By Selma Oransay

. Ureterolysis is an advanced surgical technique that involves dissection of the ureter from pelvic brim to the ureteric tunnel to avoid injury or freeing the ureter from endometriotic lesions. This manipulation usually requieres advanced surgical training and skill. In…

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T-cell-targeted immunotherapy and immune checkpoint inhibitors for the treatment of endometriosis

T-cell-targeted immunotherapy and immune checkpoint inhibitors for the treatment of endometriosis By Nasuhi Engin Aydin

Dr. Monika Abraimuk and colleagues from Poland published their review on "the importance of immunity in endometriosis" in a recent issue of the medical journal “Cellular Signaling”. A great challenge in contemporary medical issues is endometriosis which still lacks a…

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How do the couples feel when dealing with endometriosis?

How do the couples feel when dealing with endometriosis? By Eylül GÜN

The effects of endometriosis on the patients' psychosocial well-being are well known. However, not many studies have investigated how it impacts the well-being of partners and couples. A few studies focused on the male perspective of the disease, whereas some…

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Parametrial endometriosis and postoperative voiding dysfunction.

Parametrial endometriosis and postoperative voiding dysfunction. By Selma Oransay

Parametrium constitutes a complex connective tissue containing blood vessels, the ureter, and the inferior hypogastric plexus, that extends from the lateral surface of the cervix and vagina to the lateral pelvic wall. Parametrial endometriosis may involve the vessels, nerves, and…

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The association between severe endometriosis and venous thromboembolism

The association between severe endometriosis and venous thromboembolism By Hale Goksever Celik

For clarifying the issue of whether endometriosis patients are at risk for venous thromboembolism due to both their local immune and inflammatory responses and hormonal treatments, Wiegers et al,  from the Netherlands, published an explorative cohort study entitled “Risk of…

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Researchers Develop New Mouse Model of Endometriosis

Researchers Develop New Mouse Model of Endometriosis By Özge Özkaya

Researchers from China developed a new mouse model to study endometriosis that could help researchers better understand the molecular mechanisms that lead to the development of endometriosis and develop potential new treatments for the disease.  Even though many animal models…

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Do endometriosis patients have increased risk of stroke?

Do endometriosis patients have increased risk of stroke? By Nasuhi Engin Aydin

Dr. Leslie V. Farland and colleagues from the University of Arizona, published their prospective research on the risk of stroke in women with laparoscopically confirmed endometriosis in a recent issue of a scientific journal named  “Stroke”. Endometriosis is a chronic…

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Pelvic pain characteristics in young girls with endometriosis.

 Pelvic pain characteristics in young girls with endometriosis. By Selma Oransay

The occurrence of severe and frequent pelvic pain in young women is a piece of evidence that endometriosis begins and develops at an early age. Two-thirds of women with endometriosis who were diagnosed in their adulthood reported the onset of…

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Turn around to come to the same spot: Nothing specific to predict AMH decline

Turn around to come to the same spot: Nothing specific to predict AMH decline By Bahar Yuksel

Endometriomas are challenging lesions as they might cause a decline in ovarian function either only by their presence or related to their surgery. Thus, any preoperative parameter that might give a vision to a surgeon for postoperative results is crucial.…

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Endometriosis Prediction by "Machine Learning"

Endometriosis Prediction by By Selma Oransay

To develop a predictive model for endometriosis and to re-assess the contribution of known risk factors, Blass et al. from the Hebrew University of Jerusalem, Jerusalem, Israel used the data of the UK biobank by machine learning-based models. They compared and…

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Placenta Previa More Common Among Pregnant Women With Endometriosis

Placenta Previa More Common Among Pregnant Women With Endometriosis By Özge Özkaya

Endometriosis is associated with a higher risk of placenta previa, according to a new study published in the scientific journal Reproductive Sciences. This is the case whether the women became pregnant following in vitro fertilization (IVF). Moreover, for women with endometriosis…

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Vitamin C as a possible therapeutic agent in endometriosis

Vitamin C as a possible therapeutic agent in endometriosis By Eylül GÜN

A rather toxic environment is generated with the production of reactive oxygen species by the immune cells in endometriosis. The anti-oxidant metabolism is also altered which results in a state of oxidative stress. As a potent antioxidant, Vitamin C has…

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A call for mast cells from endometriotic lesions

A call for mast cells from endometriotic lesions By Bahar Yuksel

Endometriosis is a well-known hormonal-dependent inflammatory disease. But what type of inflammatory cells is responsible, and when does estrogen take part, are questions that have not been answered yet. In the study conducted by Alison McCallion et al, the role…

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Fibrosis is not only a histological finding in endometriosis

Fibrosis is not only a histological finding in endometriosis By Eylül GÜN

Endometriosis remains to be an active subject of research with its complex pathophysiology and the indistinct mechanisms that cause the proliferation and progression of the lesions. Besides the already known characteristics of the disease, there is strong evidence to support…

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Study Identifies Factors Associated With Risk of UrinaryTract Endometriosis Recurrence

Study Identifies Factors Associated With Risk of UrinaryTract Endometriosis Recurrence By Özge Özkaya

Being younger than age 25 and having an autoimmune disease are significant predictors of the recurrence of urinary tract endometriosis after surgery according to a new study published in the Journal of Minimally Invasive Gynecology. Adjuvant hormonal therapy, on the…

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To Remove the Ovary(ies) or Not During Hysterectomy for Endometriosis

To Remove the Ovary(ies) or Not During Hysterectomy for Endometriosis By Selma Oransay

Some surgeons prefer empiric bilateral salpingo-oophorectomy during the hysterectomy of women with endometriosis based on the knowledge that endometriosis is stimulated by endogenous estrogens, as leaving the ovaries in situ may increase the possibility of endometriosis recurrence and pelvic pain.…

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Coexistence of endometriosis and cardiovascular diseases

Coexistence of endometriosis and cardiovascular diseases By Hale Goksever Celik

The most common presenting complaints are mainly pelvic pain and infertility, most of which relate to the menstrual period. Affected women demand therapy for these symptoms of endometriosis, notably pelvic pain. Several theories have been proposed to explain the development…

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An important matter to revise: Immune system changes in endometriosis

An important matter to revise: Immune system changes in endometriosis By Eylül GÜN

Endometriosis is a multifactorial disease with unclear and obscure pathogenetic mechanisms. In their review, Chopyak et al. revised the immunopathogenic pathways that are proven and/or thought to be responsible for disease development and progression. The article was published in the…

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Endometriotic cyst fluid and the postoperative recurrence of endometriosis

Endometriotic cyst fluid and the postoperative recurrence of endometriosis By Nasuhi Engin Aydin

Dr. Xinxin Xu and colleagues from the Department of Obstetrics and Gynecology, School of Medicine, Zhejiang University, China, published their research on the viability of endometrial cells in ovarian cyst fluids in a recent issue of  “Journal of Ovarian Research”.…

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Transvaginal Ultrasound Could Be Sufficient to Properly Diagnose Deep Endometriosis and Ovarians Endometriomas

Transvaginal Ultrasound Could Be Sufficient to Properly Diagnose Deep Endometriosis and Ovarians Endometriomas By Özge Özkaya

Following the International Deep Endometriosis Analysis consensus can improve the accuracy of transvaginal ultrasound to diagnose ovarian endometriomas and deep infiltrating endometriosis, according to a new study published in the scientific journalUltrasound in Obstetrics & Gynecology. “ (…) at this…

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Endometriosis and environmental factors

Endometriosis and environmental factors By Selma Oransay

The estrogen-dependent nature of endometriosis has generally led to search endocrine-based causes. Especially, polychlorinated biphenyls, dioxins, and Dietilstilbesterol are the most studied chemicals in the literature. Interesting data that needs confirmation in the future also suggest a link with night…

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The predictive value of operative findings concerning ovarian reserve

The predictive value of operative findings concerning ovarian reserve By Bahar Yuksel

Having endometrioma is a proven factor that affects the ovarian reserve of patients with endometriosis. Not only its presence but also the surgery applied, and concomitant disease stage might affect the reserve. In this retrospective analysis conducted in Korea by Jisun…

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Fallopian tube occlusion in infertile women with endometriosis

Fallopian tube occlusion in infertile women with endometriosis By Hale Goksever Celik

Women with endometriosis suffer from fertility problems with an incidence of 40-50%. Among the pathophysiologic mechanisms resulting in impaired fertility in women with endometriosis, distorted pelvic anatomy due to adhesions,  impaired follicular quality-quantity, dysfunction of tubal peristalsis, and implantation problems…

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The Oocyte Quality in Ovarian Endometriosis

The Oocyte Quality in Ovarian Endometriosis By Selma Oransay

Endometrioma is the ovarian involvement of endometriosis affecting up to 44% of women diagnosed with the disease. Owing to the anatomical locus, ovarian endometriosis may impair folliculogenesis and oocyte competence, differing from other forms of endometriosis.  When investigating the relationship between…

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The effect of postoperative hormonal medication preferences on the recurrence rate of endometrioma

The effect of postoperative hormonal medication preferences on the recurrence rate of endometrioma By Bahar Yuksel

Endometrioma is the most investigated type of endometriosis. The recurrence after surgery is important regarding its and reoperation’s effect on ovarian functions. In the study conducted by Seung-Hye Choi et al, the researchers questioned the effect of different postoperative hormonal…

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The effects of resveratrol on endometriotic cells

The effects of resveratrol on endometriotic cells By Eylül GÜN

The current treatment methods for endometriosis still carry recurrence risks and side effects from medications. Herbal medicine has been investigated and used as an additional alternative method. Derived from several plants and found in some dietary sources, resveratrol is a…

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The best method for the diagnosis of endometriosis: SEE and BELIEVE

The best method for the diagnosis of endometriosis: SEE and BELIEVE By Eylül GÜN

Deciding on the best diagnostic procedure for endometriosis patients has been a recent subject of debate. While some clinicians believe non-invasive methods such as imaging and symptom-based treatment should be the choice in the diagnosis, some believe the best method…

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Validity of Magnetic Resonance Imaging for Deep Pelvic Endometriosis.

Validity of Magnetic Resonance Imaging for Deep Pelvic Endometriosis. By Selma Oransay

Video laparoscopy has become a valuable tool for diagnosing and managing endometriosis in recent years. In cases associated with deep infiltrating endometriosis, the need for a non-invasive diagnostic method before laparoscopic evaluation paves the way for using MRI.  The use…

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Gluten Intake May Not Have an Effect on Endometriosis

Gluten Intake May Not Have an Effect on Endometriosis By Özge Özkaya

Carbohydrate quality and certain types of fiber such as total vegetable and cruciferous vegetable fiber seem to be associated with endometriosis in women before menopause, found a new study published in the Journal of Nutrition. According to the study, it…

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Start exercising for pain relief

Start exercising for pain relief By Bahar Yuksel

Physical exercises have always been suggested for chronic pain-related diseases as well as endometriosis. However, the effect of exercise and the frequency that is effective on pain relief is unknown. In the study conducted by Ipek Ensari et al, a…

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Combined "Platelet-to-lymphocyte ratio and CA125" may be promising predictor for adhesions

Combined By Nasuhi Engin Aydin

Drs. Guo & Zhang from the Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China published their manuscript on the importance of combined "platelet-to-lymphocyte ratio and CA125 level" as a biomarker of endometriosis in a recent…

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Sex Education For The Sexual Quality Of Life

Sex Education For The Sexual Quality Of Life By Hale Goksever Celik

The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Decreased quality of life due to pelvic pain, dyspareunia, and psychological conditions such as anxiety and depression can lead to sexual dysfunction in women with endometriosis.…

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Estradiol metabolism, endometriosis and migraine

Estradiol metabolism, endometriosis and migraine By Bahar Yuksel

Endometriosis and migraine are the leading pain diseases of women of reproductive ages. As both are known to be induced by hormonal changes, in the review conducted by Joy-Fleur van der Vaart et al, the authors aimed to find out the…

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Time has come to learn more about endometriosis and take action!

Time has come to learn more about endometriosis and take action! By Eylül GÜN

It has been a long time since endometriosis was defined. Extensive population studies have shown that around 10% of women suffer from this condition. Depending on its severity, it alters the various functions of the body and causes the patients…

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Does the timing of endometriosis diagnosis affect optimal infertility treatment?

Does the timing of endometriosis diagnosis affect optimal infertility treatment? By Selma Oransay

Based on a retrospective population-linked data study in "Human Reproduction", the ESHRE journal club featured a detailed discussion with 50 participants, patients’ representatives, and experts (Paola Vigano´, Mathew Leonardi, Thomas D’Hooghe, Louise Hull), together with the authors of the original article, mainly…

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New Endometriosis Self-Assessment Tool Could Help Women Seek Timely Medical Attention

New Endometriosis Self-Assessment Tool Could Help Women Seek Timely Medical Attention By Özge Özkaya

Researchers from Korea developed a self-assessment tool that may allow women to determine their risk of endometriosis. They described the tool in an article they published in the scientific journal Obstetrics & Gynecology Science. “The devised tool appears valid and…

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How to reduce follicle loss during endometrioma surgery?

How to reduce follicle loss during endometrioma surgery? By Bahar Yuksel

Bilateral endometrioma is a critical situation to decide on further approaches when both infertility and pain are concerned. Techniques to protect ovarian functions are crucial when applying a cyst removal is inevitable. In the retrospective study conducted by Lingli Xin…

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Genomic evidence: The recognition of endometriosis as an inflammatory systemic disease

Genomic evidence: The recognition of endometriosis as an inflammatory systemic disease By Nasuhi Engin Aydin

Dr. Bao and associates from Shangai-China published a new article on the genomic features of endometriosis that could yield information on its inflammatory basis and possible therapeutic potential in a recent issue of “Frontiers ın Immunology”. Endometriosis is a systemic process…

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Evaluation of retrocervical and parametrial deep endometriosis by detailed ultrasonography

 Evaluation of retrocervical and parametrial deep endometriosis by detailed ultrasonography By Selma Oransay

The accuracy of ultrasonographic diagnosis of deep endometriosis in the retrocervical and parametrial areas may be poor due to the variable morphology of endometriotic lesions, the complex structure of the posterior parametrial compartment, and the difference in examiners' experience level.…

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Research Identifies Blood Proteins Associated With Endometriosis in Adolescents

Research Identifies Blood Proteins Associated With Endometriosis in Adolescents By Özge Özkaya

Proteins related to angiogenesis or the formation of new blood vessels and cellular migration are enriched and more active in the blood of adolescents with endometriosis compared to healthy controls. These are the findings of a new study published in…

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Chasing gold to find endometriosis.

Chasing gold to find endometriosis. By Bahar Yuksel

Endometriosis is a disease that doesn’t have a proper preoperative diagnostic test. Thus, animal models to study endometriosis are vital to show the effects of drugs and the effects of the disease on the body. In the study conducted by…

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Endometriosis-associated infertility: How to manage?

Endometriosis-associated infertility: How to manage? By Hale Goksever Celik

Although the underlying reason for endometriosis has not been fully established, there is an association between endometriosis and infertility. Endometriosis is thought to be involved in 40-50 percent of infertility cases. However, natural conception can still occur even in women…

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Is it possible to reduce pain by diet in endometriosis?

Is it possible to reduce pain by diet in endometriosis? By Eylül GÜN

Endometriosis-related pain is one of the most common symptoms of endometriosis that significantly affects the patient's quality of life. The peripheral and central sensitization, caused by chronic inflammation activation, may result in referred pain. The pain perception was shown to…

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Would it be possible to diagnose endometriosis from a vaginal swab?

Would it be possible to diagnose endometriosis from a vaginal swab? By Nasuhi Engin Aydin

Ectopic endometrial tissues with new vessel formations in an inflammatory background have a component of mast cell-derived exosomal tRF-Leu-AAG-001 promoting inflammation and angiogenesis. This information is according to the paper published in a recent issue of the journal “BMC Women’s Health”,…

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Ovarian Endometrioma Reduces the Chance of a Successful Pregnancy With IVF

Ovarian Endometrioma Reduces the Chance of a Successful Pregnancy With IVF By Özge Özkaya

Ovarian endometrioma significantly decreases ovarian reserve or the capacity of the ovaries to produce eggs that are able to be fertilized and give rise to a successful pregnancy. This is according to a study published in the scientific journal Medicine.…

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A new potential therapeutic target in endometriosis: Galectin-3

A new potential therapeutic target in endometriosis: Galectin-3 By Eylül GÜN

The endometrial cells migrate and attach to the peritoneal surface according to the most widely accepted retrograde menstruation theory in endometriosis development. Given that only 10% of women have endometriosis, it is thought that some additional factors contribute to the…

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The role of oxidative stress on endometriosis symptomatology

The role of oxidative stress on endometriosis symptomatology By Bahar Yuksel

Endometriosis is not only a hormonal disease, but it is also an inflammatory illness provoked by hormones. In the review conducted by Hossein Ansariniya et al., from Iran, the relation between oxidative stress, free radicals, free iron, and the development of…

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How do regional differences affect the incidence rates of endometriosis?

How do regional differences affect the incidence rates of endometriosis? By Eylül GÜN

Despite all the ongoing work for endometriosis awareness, it continues to be an underdiagnosed disease. Several different factors are responsible for this. The variations of its symptomatology play a big part as well as the lack of understanding of the…

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Fertility assessment and surgical approach in endometriotic patients.

Fertility assessment and surgical approach in endometriotic patients. By Selma Oransay

The prevalence of endometriosis is around 50-70% in women with pelvic pain, and it has been reported as 50% in patients with infertility. Severe adhesive disease associated with advanced endometriosis is a cause of fertility impairment. The relationship between endometriosis…

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The effect of chronic endometritis on pregnancy outcomes in infertile women having minimal/mild endometriosis

The effect of chronic endometritis on pregnancy outcomes in infertile women having minimal/mild endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease that is frequently diagnosed in reproductive-aged women. Infertility can be associated with endometriosis in these women depending on several pathophysiologic mechanisms such as anatomic distortion, and implantation failure. Thus pregnancy rate is so important, especially…

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Endometrioma and its relation with fibrosis, dysmenorrhea, and AMH levels.

Endometrioma and its relation with fibrosis, dysmenorrhea, and AMH levels. By Bahar Yuksel

Endometrioma is an indicator of endometriosis which makes it easy to diagnose the disease for most clinicians. But the symptoms and relationship of endometrioma with menstrual pain severity and the ovarian reserve as well as its markers are not well…

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Understanding the expression of endometriosis-related pain: A barrier to overcome

Understanding the expression of endometriosis-related pain: A barrier to overcome By Eylül GÜN

It is difficult to describe the feeling of pain, one of the most important symptoms of endometriosis because it is subjective. Endometriosis-related pain is proven to be underestimated by some clinicians resulting in the patient getting a late diagnosis. It…

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Postoperative outcomes of deep intestinal endometriosis surgery.

 Postoperative outcomes of deep intestinal endometriosis surgery. By Selma Oransay

Invasion of endometriotic lesions to the bowels' mucosal and/or muscular levels is called intestinal deep endometriosis. These lesions are most frequently found in the rectosigmoid colon, followed by the rectum, ileum,  appendix, and caecum. The optimal surgical approach to intestinal deep…

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Soluble CD90 : a potential serum biomarker in endometriosis

Soluble CD90 : a potential serum biomarker in endometriosis By Nasuhi Engin Aydin

Dr. Bochev and colleagues from several medical centers in Bulgaria published their research on the role of a possible serum biomarker in diagnosing endometriosis in a recent issue of the journal named “Disease Markers”. The definitive diagnosis of endometriosis, an…

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Immune cells in peritoneal endometriosis

Immune cells in peritoneal endometriosis By Nasuhi Engin Aydin

Dr. Burcu Ersoy and associates from The University of Sydney, Australia, published their interesting study on surgically removed peritoneal endometriosis tissues in the journal named "F&S Science". It is still a dilemma how ectopic endometrial tissues attach to the peritoneum, persist…

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Ankylosing Spondylitis and Endometriosis

Ankylosing Spondylitis and Endometriosis By Hale Goksever Celik

There are several theories contributing the development of endometriosis: one of the proposed pathophysiological mechanisms is the abnormality in immune and inflammatory system. Several immunologic diseases coexist with endometriosis depending on the common immunologic characteristics such as Tumor necrosis Factor…

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The accuracy of transvaginal ultrasound and magnetic resonance imaging for deep urinary tract endometrisis.

The accuracy of transvaginal ultrasound and magnetic resonance imaging for deep urinary tract endometrisis. By Selma Oransay

The prevalence of urinary tract endometriosis is 19-53% in patients within deep infiltrating endometriosis cases. The bladder and ureteral are the most common sites of the involvement. While preparing a radical surgery for a patient with deep endometriosis, the diagnosis…

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A search for a marker to show the malignancy risk of endometriomas

A search for a marker to show the malignancy risk of endometriomas By Bahar Yuksel

The premalignant features and precursors that show the malignant potential in endometriomas are not well-known. In the systematic review conducted by Ludovica Bartiromo et al, the markers for malignant transformation have been analyzed and recently published in a recent issue of…

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Endometriosis in transmasculine people

Endometriosis in transmasculine people By Eylül GÜN

“Transmasculine” refers to people who were assigned female at birth but later identify themselves with masculinity. If they choose to transition to the male gender, they are then prescribed long-term testosterone and some may want to undergo a hysterectomy as…

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Chronic pelvic pain and endometriosis

Chronic pelvic pain and endometriosis By Selma Oransay

Patients may have an average of 7 clinical visits before being diagnosed with endometriosis. Understanding chronic pain conditions including endometriosis-associated pain, and developing chronic pelvic pain benefits the management of the patients. The role of central sensitization, comorbid conditions, and…

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Who Is Diagnosing my Endo?

Who Is Diagnosing my Endo? By Özge Özkaya

It is possible to acquire the skills necessary to diagnose endometriosis lesions as well as adenomyosis using three-dimensional rectosonography after a short learning period in an expert radiology center. This is according to a new study by French researchers published…

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Is it possible to predict recurrence after ovarian endometriosis surgery?

Is it possible to predict recurrence after ovarian endometriosis surgery? By Eylül GÜN

The current treatment methods for endometriosis both have their flaws: the medical treatment is sometimes ineffective and the surgical treatment comes with a high rate of recurrence. Even though new surgical modalities have been developed, laparoscopic cyst removal continues to…

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The association between inflammatory cytokines and fertility in women with endometriosis

The association between inflammatory cytokines and fertility in women with endometriosis By Hale Goksever Celik

Women with endometriosis suffer not only from a broad spectrum of symptoms including pain including dysmenorrhea, dyspareunia, and chronic pelvic pain but also fertility problems. Endometriosis-associated infertility develops depending on a combination of several mechanisms such as distorted pelvic anatomy,…

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The clearance system is defective for women who develop endometriosis

The clearance system is defective for women who develop endometriosis By Bahar Yuksel

Endometriosis is both a hormonal and an immune disease thus overcoming the immune response by improving the underlying mechanism would help fight the disease. In the study conducted by Dr.Guidice group at the University of California San Francisco, San Francisco, CA,…

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Surgery Improves the Sex Life and Sleep of Women With Endometriosis

Surgery Improves the Sex Life and Sleep of Women With Endometriosis By Özge Özkaya

Endometriosis surgery improves patients’ quality of life, sexual function, and sleep confirms a new study by Turkish researchers published in the scientific journal Archives of Gynecology and Obstetrics. According to the first author Dr. Belfin Nur Arici Halici of the…

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Does inhibiting the formation of the new blood vessels aid in endometriosis treatment?

Does inhibiting the formation of the new blood vessels aid in endometriosis treatment? By Eylül GÜN

Current treatment modalities for endometriosis include a hormonal alteration which has many side effects and surgical removal which has a high postoperative recurrence rate. Alternative non-hormonal treatment methods have been investigated and anti-angiogenic therapy is one of them. Dr.s Chung…

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Is there a component of "microflora imbalance" in endometriosis?

Is there a component of By Nasuhi Engin Aydin

Dr. Oishi and colleagues from Ryukyus and Mie Universities, Japan, published a prospective cohort study on the microbiota of the female genital tract in the journal "Reproductive Medicine and Biology". Recent studies have found a small number of bacteria in…

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Early menarche increases the risk of endometriosis.

Early menarche increases the risk of endometriosis. By Selma Oransay

Early menarche is the first menstrual bleeding occurring before 12 years of age. The timing of normal puberty in girls varies between nations due to genetic, socioeconomic, and environmental factors. Notably, the age of menarche decreased significantly in teenagers born…

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How does endometriosis affect the life course of the patients?

How does endometriosis affect the life course of the patients? By Eylül GÜN

Endometriosis, as a chronic disease has impairing effects on women’s lives. Patients carry psychological, social, and work-related burdens along with debilitating physical symptoms. Studies have been performed on these issues at a particular time in patients’ lives, however, only a…

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The relation between body mass index and endometriosis

 The relation between body mass index and endometriosis By Selma Oransay

The studies have emphasized a link between low BMI values and endometriosis, however, this conclusion may be questionable when the estrogen dependence of the disease is concerned. Excess adipose tissue may produce higher circulating estrogen that may result in an…

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Does endometrioma affect ovarian reserve to reach pregnancy and birth?

Does endometrioma affect ovarian reserve to reach pregnancy and birth? By Hale Goksever Celik

Endometrioma occurs in approximately 17-44% of women with endometriosis. These women suffer from dysmenorrhea, dyspareunia, chronic pelvic pain, and also infertility. Although the exact mechanism explaining endometriosis-associated infertility has not been elucidated, distorted pelvic anatomy, impaired ovarian function, altered microenvironment-endometrial receptivity,…

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Adenomyosis Increases Risk of Surgical Complications

Adenomyosis Increases Risk of Surgical Complications By Özge Özkaya

Adenomyosis increases the risk of deep endometriosis surgery complications, according to a new study published in the journal Scientific Reports. Patients with deep endometriosis and adenomyosis should therefore be informed about this risk before undergoing surgery. Adenomyosis occurs together with…

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The consequence of COVID-19 pandemic on endometriosis patients

The consequence of COVID-19 pandemic on endometriosis patients By Selma Oransay

The relevant policies and restrictions concerning Covid-19 have prevented patients from accessing medical care. Similarly, standard care for endometriosis patients has also been negatively impacted by postponed or canceled appointments and suspended surgeries across the countries. Women trying to cope…

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Preferential expression of some membrane type matrix metalloproteinase proteins

Preferential expression of some membrane type matrix metalloproteinase proteins By Nasuhi Engin Aydin

Dr. Maoga and associates from academic institutions located in Germany and Kenya have published their findings on the immunohistochemical expression of MT-MMP proteins, namely MT2-MMP (MMP15) and MT3-MMP (MMP16) in the eutopic endometrium of healthy and endometriotic patients; and also…

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The evaluation of sexual dysfunction in infertile women

The evaluation of sexual dysfunction in infertile women By Eylül GÜN

Infertility constitutes a serious health problem in women and men worldwide. The most common causes of women’s infertility are reported to be endometriosis and polycystic ovarian syndrome. The prevalence of infertility in women with endometriosis is as high as 50%.…

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Comparison of imaging techniques for estimating the depth of bowel wall infiltration by endometriosis.

Comparison of imaging techniques for estimating the depth of bowel wall infiltration by endometriosis. By Selma Oransay

The surgical removal of deep endometriosis is the cornerstone of the management. However, the decision for the varying surgical approach types ranging from conservative management (shaving) to segmental or discoid resection depends on the depth of infiltration within the bowel wall, which…

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Self-Management Strategies for Endometriosis

 Self-Management Strategies for Endometriosis By Özge Özkaya

Many self-management strategies for endometriosis are not more effective at reducing the symptoms of the disease compared to placebo or hormonal therapies, according to a new study published in the journal Reproductive Sciences.  The authors, therefore concluded that “no recommendations…

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Social media and endometriosis management

Social media and endometriosis management By Selma Oransay

Endometriosis has a negative impact on social life, work, daily activities, personal relationship, and overall quality of life. A study from Australia recently published in the Australian New Zeland Journal of Obstetrics and Gynaecology reports that social media helps these…

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Atherosclerosis is augmented in laboratory mice by experimental endometriosis

Atherosclerosis is augmented in laboratory mice by experimental endometriosis By Nasuhi Engin Aydin

Dr. Taylor group from Yale School of Medicine, New Haven, CT, USA has published their experimental study in the "American Journal of Obstetrics & Gynecology" on atherosclerosis following endometriosis induction in laboratory mice. The basic inflammation process in endometriosis patients…

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No way to sleep when you suffer from pain

No way to sleep when you suffer from pain By Bahar Yuksel

Having chronic disease might alter the sleep quality and disturb sleeping periods. Besides insomnia, endometriosis itself changes the pain sensitivity and increases the body’s reaction to inflammatory and painful inputs. Thus, as a chronic and painful long-term situation, the relation…

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Geography May Influence Risk of Endometriosis

Geography May Influence Risk of Endometriosis By Özge Özkaya

The risk of developing endometriosis seems to be geographically heterogeneous across France, according to results from a study published in the journal Scientific Reports. The study identified  20 high-risk hotspots around the country. These showed similar results for non-adenomyosis endometriosis…

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How possible is it to diagnose endometriosis from a urine sample?

How possible is it to diagnose endometriosis from a urine sample? By Eylül GÜN

The development of non-invasive diagnostic methods in endometriosis is essential for successful surveillance. Various biomarkers have been used for this purpose, including biomarkers from serum, peritoneal irrigation fluid, endometrial tissue biopsy, and urine. Dr. Chen et al. from Taiwan conducted…

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Abdominal wall endometriosis is not a rare disease as supposed

Abdominal wall endometriosis is not a rare disease as supposed By Hale Goksever Celik

Abdominal wall endometriosis is an iatrogenic type of endometriosis defined as the localization of endometrial glandular and stromal tissue on the abdominal wall including skin, the rectus abdominis muscle, and rectus muscle sheath. Cyclical pain, mass located on the abdominal…

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The incidence of ovarian cancer after histologically diagnosed endometriosis.

The incidence of ovarian cancer after histologically diagnosed endometriosis. By Selma Oransay

Ovarian cancer has the highest mortality rate among gynecologic cancers. Furthermore, these patients are generally diagnosed in advanced stage due to their non-symptomatic nature. Therefore, preventative strategies have enormous importance for the management of ovarian cancer.  Dr. Hermens and colleagues…

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How reliable are the patient questionnaires in predicting endometriosis?

How reliable are the patient questionnaires in predicting endometriosis? By Eylül GÜN

It is well known that the diagnosis of endometriosis is delayed in the majority of patients throughout the world. The burden that this brings has many effects on the patients’ lives as well as the society. The radiological developments in…

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Distribution of tubal endometriosis

Distribution of tubal endometriosis By Selma Oransay

The incidence of tubal endometriosis was previously reported in a percentage of 4 to 11, but recent studies gave a prevalence up to 42.5 % which indicates the actual incidence of this disease is underestimated.  Some studies in recent literature…

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A novel contribution to patient management in endometriosis by immunohistochemistry

A novel contribution to patient management in endometriosis by immunohistochemistry By Nasuhi Engin Aydin

Dr. Tarumi and associates from the Kyoto Prefectural University of Medicine, Kyoto, Japan published their retrospective cohort study on the importance of progesterone receptors on recurring ovarian endometriosis in "The Journal of Clinical Endocrinology & Metabolism". Surgery for endometriosis is…

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 Which of the suggested environmental risk factors are indeed related to endometriosis?

 Which of the suggested environmental risk factors are indeed related to endometriosis? By Eylül GÜN

Endometriosis is a complex disease with genetic and environmental factors in its poorly understood pathogenesis. Even though many epidemiological studies in the literature have proposed several risk factors, the lack of clear establishment and modification of these potential risk factors…

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Potential New Approach to Treat Endometriosis

Potential New Approach to Treat Endometriosis By Özge Özkaya

Inhibiting ribosome biogenesis could be a potential therapeutic approach for endometriosis according to a new study published in the scientific journal Biomedicines. Ribosome biogenesis plays a key role in protein homeostasis during cell growth and division. Previous research has shown…

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Listening to patients’ complaints is the first step on the way to a diagnosis of endometriosis.

Listening to patients’ complaints is the first step on the way to a diagnosis of endometriosis. By Hale Goksever Celik

Early diagnosis and management of endometriosis are not possible due to the wide spectrum of symptoms and absence of non-invasive diagnostic biomarkers. Particularly the adolescent population is at risk for the diagnostic delay because pelvic pain and dysmenorrhea are very…

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Are the studies based on the nationwide databases more accurate?

Are the studies based on the nationwide databases more accurate? By Eylül GÜN

One of the most common localizations of endometriosis is the ovaries, and therefore, ovarian endometriomas are among the most surgically treated endometriotic lesions. Dr. Roman from Denmark has recently written an editorial about the surgical interventions on ovarian endometrioma and…

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Endometriosis diagnosis and management based on the best available evidence from published literature

Endometriosis diagnosis and management based on the best available evidence from published literature By Selma Oransay

ESHRE, "European Society of Human Reproduction and Embryology" published a Guideline for the diagnosis and treatment of endometriosis in 2005 and then revised it in 2013. Based on new research and development there was a need to renew the last…

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Medicinal Cannabis Use for Endometriosis in Australia and New Zeland

Medicinal Cannabis Use for Endometriosis in Australia and New Zeland By Özge Özkaya

Cannabis use leads to positive outcomes for the management of endometriosis according to the results of an online survey among patients from Australia and New Zealand. These findings, which were published in the journal Cannabis and Cannabinoid Research suggest that…

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Endometriosis information coming from the social media

Endometriosis information coming from the social media   	By Bahar Yuksel

Today’s changing and evaluating world led everything to be lived online. For sure endometriosis and searching for cures or support for endometriosis have been transferred to online social media platforms too. The study conducted by Julian Matthias Metzler et al…

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What are the most common symptoms of endometriosis and how are they related to age?

What are the most common symptoms of endometriosis and how are they related to age? By Eylül GÜN

Even though the incidence of endometriosis is relatively high and numerous studies are being conducted to elucidate its pathogenesis, it is still a highly underdiagnosed and undertreated disease. The symptoms of the disease are well-known; however, the correlation between the…

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A revolutionary view on endometriosis related pain

A revolutionary view on endometriosis related pain By Nasuhi Engin Aydin

Dr. Lydia Coxon and colleagues from Oxford University, UK, have recently published their cross-sectional study on the categorization of endometriosis-related pain in the journal "Frontiers in Pain Research". As a chronic inflammatory condition, endometriosis results in pelvic pain, dysmenorrhea, and…

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Prevalence of endometriosis and adenomyosis by transvaginal ultrasound.

Prevalence of endometriosis and adenomyosis by transvaginal ultrasound. By Selma Oransay

Women who present dyspareunia, dysmenorrhea, dysuria, dyschezia, chronic abdominal, and pelvic pain, and infertility would benefit from the early investigation. If the correct diagnosis of endometriosis and/or adenomyosis can be made in advance, early treatment will improve the quality of…

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Mindfullness Can Hep Reduce Endometriosis Pain

Mindfullness Can Hep Reduce Endometriosis Pain By Özge Özkaya

A brief mindfulness-based intervention can be useful in managing pain related to endometriosis and restoring patients’ psychological well-being, found a new study published in the European Journal of Pain. This finding contributes to the applicability of mindfulness-based interventions in people…

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Planning surgery for recto-sigmoid endometriosis with 3D virtual models.

Planning surgery for recto-sigmoid endometriosis with 3D virtual models. By Selma Oransay

Efforts to reduce the high complication rate of rectosigmoid surgery in deeply infiltrated endometriosis are of great interest to gynecologists. 3D printing, currently used in various surgical specialties to support surgical planning and guide intraoperative procedures may be a way…

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Non-invasive diagnostic tools for endometriosis revisited

Non-invasive diagnostic tools for endometriosis revisited By Nasuhi Engin Aydin

Dr. Signorile and associates from the Italian Endometriosis Foundation have published the results of their retrospective study on a large cohort of endometriosis patients in a recent issue of the periodical, In Vivo. Endometriosis lacks precise scientific knowledge and this brings…

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The underlying reason of implantation failure in women with endometriosis-associated infertility

The underlying reason of implantation failure in women with endometriosis-associated infertility By Hale Goksever Celik

Endometriosis is most frequently encountered in reproductive-aged women, with a prevalence of 10-15% in the general population. However, endometriosis is more frequently diagnosed in infertile women, with a prevalence of 25-40%. Although the exact mechanism explaining the association between endometriosis…

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Cannabis use in the management of endometriosis-related pain during the COVID19 pandemic

Cannabis use in the management of endometriosis-related pain during the COVID19 pandemic By Eylül GÜN

Pain management in endometriosis has been challenging owing to many reasons. Since the pathways that cause pain in endometriosis have not been elucidated extensively, the medical and surgical management of pain remains to be symptomatic. Alternative pain management methods have…

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Prolactin receptor antibodies: A novel treatment proposal for endometriosis

Prolactin receptor antibodies: A novel treatment proposal for endometriosis By Eylül GÜN

Prolactin, a hormone that also acts as a proinflammatory cytokine through its receptor PRLR has been shown to be involved in endometriosis pathogenesis. Previous studies reported that women suffering from endometriosis had elevated prolactin levels. Also, in experimental studies done…

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A French National Study Concerning The "Recovery Protocol" After Deep Infiltrating Endometriosis Surgery.

A French National Study Concerning The By Selma Oransay

In recent years especially for complex surgeries, enhanced recovery after surgery (ERAS) programs have been implemented in several surgical specialties. This is based on a multimodal and multidisciplinary approach centered on the patient’s perioperative situation designed to improve patient management and reduce…

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International Working Group's review on endometriosis classification systems

International Working Group's review on endometriosis classification systems By Nasuhi Engin Aydin

International Endometriosis Working Group including AAGL, ESHRE, ESGE, and WES published a comprehensive review on endometriosis classification, staging, and reporting systems in a recent issue of the journal named "Facts, Views & Vision in Obstetrics and Gynecology". Classification and staging…

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Imaging Techniques Able to Predict Depth of Endometriosis Before Surgery

Imaging Techniques Able to Predict Depth of Endometriosis Before Surgery By Özge Özkaya

Transvaginal ultrasound (TVUS) and pelvic magnetic resonance imaging (MRI) performed by a specialist can accurately predict the depth of rectosigmoid endometriosis before surgery, according to a new study published in the Journal of Minimally Invasive Gynecology. Both approaches are similar…

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A novel scoring tool to standardize surgical complexity for gynecologists.

A novel scoring tool to standardize surgical complexity for gynecologists. By Selma Oransay

The field of gynecologic surgery needs a more comprehensive, objective, and reproducible method for assessing and communicating surgical complexity than the current approach. Actually, there is no formal image-based system that allows surgeons to categorize and communicate the complexity of…

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An important enigmatic promoter of endometriosis: immune dendritic cells

An important enigmatic promoter of endometriosis: immune dendritic cells By Nasuhi Engin Aydin

Dr. Larinha and associates from a Brasilian academic center have published their comprehensive review on the role of immune dendritic cells in the pathogenesis of endometriosis in a recent issue of the "Journal of Reproductive Immunology". Antigen-presenting dendritic cells of…

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A quick insight into the latest research on endometriosis diagnosis and management

A quick insight into the latest research on endometriosis diagnosis and management By Eylül GÜN

Endometriosis research has been expanding with many new studies ranging from new techniques and markers in diagnosis to updates in clinical management and treatment of the disease. The journal Frontiers in Surgery recently brought together articles that reflect important and…

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Immunotherapy in endometriosis: a challenging research topic

Immunotherapy in endometriosis: a challenging research topic By Nasuhi Engin Aydin

Dr. Maksym and associates from academic centers in Poland have published their comprehensive review on endometriosis emphasizing the immunological aspects of the disease in a recent issue of the "Journal of Clinical Medicine". Even though endometriosis is a multifactorial disease,…

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Algorithm for pain management in endometriosis

Algorithm for pain management in endometriosis By Selma Oransay

One of the debilitating symptoms of endometriosis is pain. Mostly due to delayed diagnosis and the high recurrence rate, even after the surgical and hormonal therapy pain control may not be sufficient causing the patient to suffer for decades.  Endometriosis-associated…

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A New Non-Invasive Marker for Endometriosis?

A New Non-Invasive Marker for Endometriosis? By Özge Özkaya

The reactivity of serum immunoglobulin G (IgG) with fucose-specific lectins AAL, LCA, and LTA could be a useful diagnostic biomarker for endometriosis, according to a new study published in the Journal of Inflammation Research. It could also be a clinical…

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Is "non-hormonal therapy" effective in women with endometriosis-associated pain?

Is By Hale Goksever Celik

Women with endometriosis require effective treatment due to the negative impact of the disease on quality of life. Hormonal treatments including oral contraceptives, and progestins are usually recommended to suppress ovulation and decrease pelvic pain. However, some women do not…

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Risk of cardiovascular disease in endometriosis patients

Risk of cardiovascular disease in endometriosis patients By Eylül GÜN

A well-known fact about endometriosis is the inflammatory processes that underlie its pathophysiology. The inflammatory markers have been thought to play a role in many additional disorders in endometriosis patients. One of the primary markers of inflammation is C-reactive protein…

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The consequences of endometriosis on the quality of life

The consequences of endometriosis on the quality of life By Hale Goksever Celik

The most common clinical findings of endometriosis patients are pelvic pain and fertility problems, resulting in impairment of quality of life. These women are affected especially during the menstruation period. Olliges et al., from Germany and Switzerland, published a study…

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Surgery for the Treatment of Endometriosis of the Diaphragm and Thorax

Surgery for the Treatment of Endometriosis of the Diaphragm and Thorax By Özge Özkaya

Diaphragmatic and thoracic endometriosis starts in the abdominal wall of the diaphragm and later invades the thorax, based on findings from a series of patients surgically treated for the disease, reports a study published in the Journal of Gynecology Obstetrics…

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Diaphragmatic defects, liver herniations and catamenial pneumothorax

Diaphragmatic defects, liver herniations and catamenial pneumothorax By Nasuhi Engin Aydin

Dr. Arakawa and associates from The Jikei Katsushika Medical Center, Japan, have published their recent case of catamenial pneumothorax with diaphragmatic defect and liver herniation in the "Journal of Cardiothoracic Surgery". Catamenial pneumothorax is an uncommon condition with a reported…

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Endometriosis of the Diaphragm, What do the Doctors Know About it?

Endometriosis of the Diaphragm, What do the Doctors Know About it? By Özge Özkaya

The median time between the first consultation with a primary care physician and receiving a diagnosis of endometriosis of the diaphragm is two years according to a study by U.K. researchers. In the worse case, it took 23 years for…

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The largest series of diaphragmatic endometriosis

The largest series of diaphragmatic endometriosis By Bahar Yuksel

Diaphragmatic endometriosis is one of the most common extra pelvic endometriosis types, yet the correct incidence is unclear. In the study conducted by Ceccaroni Marcello et al from the International School of Surgical Anatomy, Verona, Italy, the authors analyzed the…

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Diaphragmatic endometriosis

Diaphragmatic endometriosis By Selma Oransay

Diaphragmatic endometriosis is a rare clinical condition that may show signs and symptoms like chest pain, right upper quadrant abdominal pain, shoulder pain, pleuritic pain, hemothorax, pneumothorax, hemoptysis, and thoracic endometriosis syndrome while the major part of the patients is…

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Thoracic endometriosis: the most frequent endometriosis involvement outside abdominopelvic cavity

Thoracic endometriosis: the most frequent endometriosis involvement outside abdominopelvic cavity By Nasuhi Engin Aydin

Six to ten percent of reproductive-age women are affected by endometriosis, and about 12% are estimated to be outside the abdominopelvic cavity - the most frequent location being the thorax. Endometriosis within the pulmonary parenchyma or on the diaphragm and…

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Urinary Tract Endometriosis

Urinary Tract Endometriosis By Bahar Yuksel

Endometriosis is mostly seen in patients of fertile age, and urinary tract endometriosis affects 1.2 to 6% of women with endometriosis. French coloRectal Infiltrating ENDometriosis Study (FRIENDS) group investigated the characteristics of urinary tract endometriosis in 232 patients from 31 centers. Authors…

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Which surgical technique is best for rectal endometriosis?

Which surgical technique is best for rectal endometriosis? By Eylül GÜN

One of the common sites for deep endometriosis is the intestines, with a rate of 3-37%. Intestinal endometriosis constitutes a serious cause of gastrointestinal symptoms, pain, and the alteration of the quality of life, with the rectum and sigmoid colon being…

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Nerve-sparing technique for deep infiltrating endometriosis and its impacts on pelvic organ and sexual functions.

 Nerve-sparing technique for deep infiltrating endometriosis and its impacts on pelvic organ and sexual functions. By Selma Oransay

Deep infiltrating endometriosis and involvement of parametrium cause severe pelvic pain and dysfunction of some pelvic organs resulting in a reduction in women's quality of life. Although surgery for DIE aims to relieve pelvic pain, entering into the posterior parametrial…

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Effects of Bowel Endometriosis Surgery on Mode of Delivery

Effects of Bowel Endometriosis Surgery on Mode of Delivery By Özge Özkaya

Less than a third of doctors counsel women about the possible effects of surgical treatment of bowel endometriosis on their mode of delivery should they become pregnant, according to a new study published in the Journal of Obstetrics and Gynaecology.…

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A comparison of endometriosis Classifications: rASRM, EFI or Enzian?

A comparison of endometriosis Classifications: rASRM, EFI or Enzian? By Selma Oransay

None of the endometriosis classifications provide a clinically valuable system since the very first description of the disease in 1860. One unique terminology to describe the localization and the extension of the disease is needed, which should be the same…

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Egg or chicken, which is causing bladder symptoms, DIE or surgery for DIE?

Egg or chicken, which is causing bladder symptoms, DIE or surgery for DIE? By Bahar Yuksel

Urinary symptoms could be overwhelming and sometimes could be hidden behind pain symptoms, but still might cause secondary damages on kidneys and bladder if remain undetected. In the prospective study conducted by Laterza et al, the authors questioned whether the…

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Surgery before in-vitro fertilization – Is it beneficial in patients with deep endometriosis?

Surgery before in-vitro fertilization – Is it beneficial in patients with deep endometriosis? By Eylül GÜN

Deep pelvic endometriosis is thought to be related to infertility by altering the pelvic environment and anatomy due to pelvic adhesions, and the changes in endometrial receptivity contribute to it. The discussion on whether the surgical intervention was beneficial started…

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Quality of life assessment in women with endometrioma

Quality of life assessment in women with endometrioma By Eylül GÜN

Like most chronic diseases, endometriosis poses a significant risk of diminishing the quality of life in patients suffering from it, particularly with its most considerable symptom; chronic pelvic pain. Although it is known that endometriosis is more common in East…

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Evaluation of daily diary for endometriosis-related pain.

Evaluation of daily diary for endometriosis-related pain. By Selma Oransay

Some endometriosis patient-reported outcomes elements have been previously developed in accordance with regulatory and best practice guidelines including Endometriosis Pain Daily Diary, the Endometriosis Symptom Diary, and Endometriosis Impact Scale. The aim of this study was to develop another content-valid…

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Endometriosis: Beyond the naked eye visibility

Endometriosis: Beyond the naked eye visibility By Bahar Yuksel

The gold standard method for endometriosis diagnosis is histopathologic evaluation of the resected lesions. The study conducted by Sara-Michelle Gratton et al. in Canada evaluated the possible effect of developed laparoscopic skills and equipment on the endometriosis diagnosis, and whether…

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Full understanding the role of nervous system in endometriosis could yield new gateways to novel therapeutic approaches

Full understanding the role of nervous system in endometriosis could yield new gateways to novel therapeutic approaches By Nasuhi Engin Aydin

Dr. Velho and associates from Berlin, Germany have recently published their comprehensive review on the role of the nervous system in endometriosis in a recent issue of “International Journal of Molecular Sciences”. Understanding the role of the peripheral nervous system…

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Endometriosis Seems to Affect The Development of the Embryo

Endometriosis Seems to Affect The Development of the Embryo By Özge Özkaya

Embryos development is impaired in embryos from women with endometriosis found a new study published in the Journal of Assisted Reproduction and Genetics. In spite of this, the outcomes of in vitro fertilization (IVF) are similar for patients with endometriosis…

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Is intrauterine insemination effective in women having endometriosis-associated infertility?

Is intrauterine insemination effective in women having endometriosis-associated infertility?  By Hale Goksever Celik

The most common presenting complaints of women with endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Affected women demand therapy for these symptoms of endometriosis, notably fertility problems. Several underlying mechanisms have been proposed to explain endometriosis-associated infertility including anatomic…

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The necessity of laparoscopy for unexplained infertility.

The necessity of laparoscopy for unexplained infertility. By Selma Oransay

The standard for accepting a couple as "infertile" is the inability to conceive after 12 months of regular unprotected intercourse. When this condition is met, assessing the number of motile sperm in the male partner and certifying the patency at…

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The Role of Endometrial Cytokines on the Infertility in Endometriosis Patients

The Role of Endometrial Cytokines on the Infertility in Endometriosis Patients By Eylül GÜN

The intrauterine microenvironment and underlying immunological mechanisms in endometriosis pathogenesis have been a popular research topic, mainly due to the efforts to comprehend the reason to elucidate infertility that these patients suffer from. Because of their superiority to other immune…

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Association of psoriasis and endometriosis

Association of psoriasis and endometriosis By Selma Oransay

Psoriasis is an immune-mediated inflammatory skin disease characterized by scalpy, red, and well-demarcated skin plaques that are observed in 2-4% of the population. Approximately 30% of psoriatic patients additionally have joint pain, stiffness, and swelling called psoriatic arthritis. The mechanism…

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How likely is it to get pregnant and have a baby after undergoing surgery for high stage endometriosis?

How likely is it to get pregnant and have a baby after undergoing surgery for high stage endometriosis? By Eylül GÜN

As one of the most common causes of infertility in women, endometriosis might be surgically interfered with depending on the stage. For Stage I and II endometriosis, surgery is recommended in the latest guidelines to ameliorate fertility rates, however, there…

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A rare but important disease: "isolated" endometriosis of the sciatic nerve

A rare but important disease: By Nasuhi Engin Aydin

Professor Marc Possover from Zurich, Switzerland has published his 16-year experience of surgical laparoscopic interventions on isolated endometriosis of the sciatic nerve in a recent issue of the official publication of the European Society for Gynecological Endoscopy; Facts, Views &…

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Physical activity and exercise in reducing endometriosis symptoms

Physical activity and exercise in reducing endometriosis symptoms By Eylül GÜN

The treatment modalities to date on endometriosis have focused on the symptomatic relief and management of chronic pain. Hormonal suppression sometimes shows intolerable side effects and is known to lose effect after some time. Surgical interventions may not provide a…

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Is it iron that calls vessels to form endometriosis

Is it iron that calls vessels to form endometriosis By Bahar Yuksel

The trigger mechanism of endometriosis formation is still under investigation. But it is clear that there is an iron overload on endometriotic lesions. In the study conducted by Guojing Li et al, the mechanism of iron on endometriosis formation has been…

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Envorinmental metals harmful for female reproductivity

Envorinmental metals harmful for female reproductivity By Selma Oransay

Heavy metals exposure in a wide range of ways is one of the main causes of increased infertility. According to the 2003 National Health Survey, nearly every pregnant woman in the USA is exposed to at least 43 hazardous chemicals…

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Pain alone is not a specific predictor for endometriosis diagnosis

Pain alone is not a specific predictor for endometriosis diagnosis By Hale Goksever Celik

The most common symptoms and signs of women with endometriosis include dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. However, diagnostic delay still occurs due to the broad clinical spectrum of the disease and the absence of non-invasive diagnostic biomarkers. Gordon et…

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The quality of life and mental health in endometriosis patients

The quality of life and mental health in endometriosis patients By Eylül GÜN

One of the most important aspects of having a chronic illness comes with its relative effect on the patients’ quality of life and mental health status. Being among the most debilitating diseases in women in the reproductive period, endometriosis is…

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How Likely Am I to Conceive After Endometriosis Surgery?

How Likely Am I to Conceive After Endometriosis Surgery? By Özge Özkaya

Women with superficial peritoneal endometriosis and just one type of lesion are more likely to conceive after surgery, according to a new study published in the International Journal of Gynecology and Obstetrics.  This is important because patients will be better…

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From Spain: execution for endometriosis and chronic pelvic pain unresponsive to conventional therapies

From Spain: execution for endometriosis and chronic pelvic pain unresponsive to conventional therapies By Selma Oransay

The current conventional therapy for chronic pelvic pain for endometriosis is defined as either hormonal or non-hormonal medical treatment starting with combined oral contraceptives progestins or dienogest, and then gonadotropin-releasing hormone analogs and/or surgery. Although conventional therapies usually are successful, still…

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The relevance of mitosis in endometriotic tissue biopsies

The relevance of mitosis in endometriotic tissue biopsies By Nasuhi Engin Aydin

Dr. Wetzk and co-workers from the Technical University, Dresden, Germany have published a retrospective study on the diagnostic impact of mitotic activity in the endometriotic lesion biopsies in the recent issue of the journal “Geburtshilfe und Frauenheilkunde”. Guidelines highly recommend a…

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The higher the Endometriosis Fertility Index, the higher the chance of getting pregnant

The higher the Endometriosis Fertility Index, the higher the chance of getting pregnant By Hale Goksever Celik

The women who desire to get pregnant may also suffer from fertility problems depending on several mechanisms such as anatomic distortion, peritoneal adhesions, tubal dysfunction, impaired quality of oocytes, and impaired endometrial receptivity. One of the most important problems in…

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Importance of Language in Communicating Endometriosis Pain

Importance of Language in Communicating Endometriosis Pain By Özge Özkaya

Language is of great importance for women with endometriosis to communicate their pain to their doctor, according to a new study published in Frontiers in Global Women's Health. The study also found that additional tools are needed to help women…

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What do endometriosis and ovarian cancer have in common?

What do endometriosis and ovarian cancer have in common? By Bahar Yuksel

While endometriosis is not a malignant disease, it is for sure known that it shares genetic disorders with cancers. In the bioinformatics study applied by Leyi Ni et al, the researchers analyzed the genetic pathways shared by both ovarian cancers…

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A novel target proposal in endometriosis: Phoenixin

A novel target proposal in endometriosis: Phoenixin By Eylül GÜN

As well as being a hormone-dependent reproductive system disorder, endometriosis is known to be multifactorial, which makes its etiopathogenetic mechanisms even harder to understand. Many new targets have been vastly evaluated with the hope of finding a new diagnostic test…

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A study design to improve the patient-centeredness in endometriosis care.

A study design to improve the patient-centeredness in endometriosis care. By Selma Oransay

It is well known that endometriosis causes impaired daily activity and productivity along with energy loss, fatigue, pelvic pain, deep dyspareunia, and further, infertility accompanies all these negative influences. The chronic nature of the disease forces clinicians to plan long-term care…

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Emotions on the 'Surgery Requirement' in patients with bowel endometriosis

Emotions on the 'Surgery Requirement' in patients with bowel endometriosis By Eylül GÜN

Endometriosis is known to have many adverse effects in patients’ lives such as a significant decrease in the quality of life, psychosocial problems, loss of productivity and focus while working. With the constant chronic pain, the patients mostly present with…

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An Overview on Treatment of endometriosis

An Overview on Treatment of endometriosis By Selma Oransay

There are different guidelines by different gynecological societies for the diagnosis and treatment of endometriosis, which is an extremely complex illness.  Kalaitzopoulos and Samartzis et al. from Switzerland worked on and compared six national and two international widely used guidelines to…

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A trial of exogenous melatonin on dysmenorrhea in women "without endometriosis"

A trial of exogenous melatonin on dysmenorrhea in women By Nasuhi Engin Aydin

In their recent article published in “European Journal of Clinical Pharmacology”,  Dr. Söderman and associates from Stockholm report the results of their randomized, double-blind, placebo-controlled trial on the effects of oral melatonin in women with dysmenorrhea -unrelated to endometriosis-. Melatonin is a hormone…

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New Endometriosis Clinical Trial Now Recruiting Participants

New Endometriosis Clinical Trial Now Recruiting Participants By Özge Özkaya

A new clinical trial investigating the effect of cognitive-behavioral therapy on quality of life in patients undergoing surgery for endometriosis is now recruiting participants. The randomized, controlled trial aims to recruit 100 participants, ages 18 to 50 with proven endometriosis…

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Which one is more effective for the preservartion of postoperative ovarian reserve?

Which one is more effective for the preservartion of postoperative ovarian reserve? By Selma Oransay

Although cystectomy is the most preferred treatment of endometrioma, it is still a matter of debate as it may cause a reduction in the quality and number of remaining follicles, especially important for women who are planning to conceive. Anti-Müllerian…

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Placenta praevia and cesarean section more common in patients with ART for Endometriosis

Placenta praevia and cesarean section more common in patients with ART for Endometriosis By Hale Goksever Celik

Even though endometriosis is known to be associated with infertility, these women still have a chance to get pregnant spontaneously or by assisted reproduction techniques (ART) with the aid of recent technological developments. A It has also been shown that…

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Matrix metalloproteinases and their role in endometriosis

Matrix metalloproteinases and their role in endometriosis By Eylül GÜN

The extracellular matrix harbors important macromolecules such as collagen and glycoproteins which are required for tissue remodeling, differentiation, and homeostasis. The main group of enzymes responsible for these properties is called matrix metalloproteinases (MMPs). It has been proven that MMPs…

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Indocyanin Green dye for recognition of occult endometriotic lesions

Indocyanin Green dye for recognition of occult endometriotic lesions By Bahar Yuksel

The surgery for endometriosis is challenging and the resection of all lesions is not accurately related to not catching all lesions under white light (WL) conventional laparoscopy. In the study conducted by Luigi Carlo Turco et al., in a tertiary…

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Evaluation of patient self-reported outcome measures for endometriosis.

Evaluation of patient self-reported outcome measures for endometriosis. By Selma Oransay

Endometriosis symptomology is multifactorial and it changes over time based on the patient's life experience, perceptions, and medical treatment. These changes require the agility of adaptation for both clinicians and patients to respond properly. The documentation of the patient's specific…

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Efficacy of cannabis on endometriosis symptoms

Efficacy of cannabis on endometriosis symptoms By Eylül GÜN

Endometriosis is related to a wide range of symptoms that affect the quality of life of patients in many aspects. Studies have shown malfunctions in the endocannabinoid system in endometriosis patients which led to the idea to target this pathway…

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Endometriosis and women’s social lives, work and education.

Endometriosis  and women’s social lives, work and education. By Hale Goksever Celik

The women with endometriosis present with a broad clinical spectrum including pelvic pain, dysmenorrhea, dyspareunia, and infertility. All of these symptoms and signs may have a negative impact on women’s lives by having endometriosis. Mastrangelo and Turnbull, from Australia, published…

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Herbicide Alters Immune System on the Route to Endometriosis

Herbicide Alters Immune System on the Route to Endometriosis By Bahar Yuksel

A popular environmental pollutant and herbicide named 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) and its receptor named aryl hydrocarbon receptor (AHR) have been suggested for causing endometriosis, but the mechanism was not clear. In the study conducted by  Mahsa Tanha et…

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Intravascular adenomyomatosis: an important entity to be alert

Intravascular adenomyomatosis: an important entity to be alert By Nasuhi Engin Aydin

Pathologists from Stanford University, USA have recently published four novel cases of intravascular adenomyomatosis co-existing with pelvic endometriosis in a recent issue of “Human Pathology”. Intravascular leiomyomatosis is characterized by the presence of smooth muscle in venous and lymphatic spaces…

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A novel in-vitro endometriosis model with KRAS and PIK3CA mutations

A novel in-vitro endometriosis model with KRAS and PIK3CA mutations By Eylül GÜN

A plethora of research has been ongoing to illuminate the pathogenesis of endometriosis which is a multifactorial disease. These studies have proven the association between some mutated cancer driver genes and endometriosis, and links between certain cancers such as ovarian…

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Is breastfeeding beneficial to endometriosis pain?

Is breastfeeding beneficial to endometriosis pain? By Nasuhi Engin Aydin

Dr. Porta team from Italian academic centers have recently published their research in “International Journal of Environmental Research and Public Health” on breastfeeding mothers who were under follow-up for histologically proven endometriosis. The hormonal milieu is believed to have an important…

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International definition and standardization for endometriosis

International definition and standardization for endometriosis By Selma Oransay

There is huge heterogeneity in classifications, subtypes, diagnostic and therapeutic interventions of endometriosis in published literature. The lack of a uniform and widely accepted terminology of the disease rose the necessity to argue and reach a common consensus with organizations,…

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Preoperative Neutrophil-to-Lymphocyte Ratio for prediction of postoperative pregnancy

Preoperative Neutrophil-to-Lymphocyte Ratio for prediction of postoperative pregnancy By Hale Goksever Celik

Among women with endometriosis, 30 to 50 percent are estimated to have infertility, and 25-50% of infertile patients are found to have endometriosis. Anatomic distortion, diminished tubal peristalsis, diminished sperm movements, dysfunctional folliculogenesis, luteal phase dysfunctions, and alterations in endometrial…

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Relationship Goals and Sexual Satisfaction for Couples Coping with Endometriosis

Relationship Goals and Sexual Satisfaction for Couples Coping with Endometriosis By Selma Oransay

"Relationship satisfaction" is based on an individual's emotional judgment. Physical and emotional obstacles may present and negatively affect relationship satisfaction. Endometriosis is associated with multiple life domains, and also includes relationship and sexual satisfaction. Sexual satisfaction, on the other hand,…

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Cross-cultural translation and adaptation of an endometriosis survey

Cross-cultural translation and adaptation of an endometriosis survey By Eylül GÜN

Endometriosis is a disease that presents heterogeneously which makes it hard to identify a causal relationship. A patient-based questionnaire called Endometriosis Participant Questionnaire (EPQ) has been originated by The World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project. It…

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A plea from pathologists: standardized protocols for adenomyosis and endometriosis  

A plea from pathologists: standardized protocols for adenomyosis and endometriosis   By Nasuhi Engin Aydin

Pathologist Drs. Camboni and Marbaix from Brussels, Belgium published their comprehensive review on adenomyosis and endometriosis titled “Ectopic endometrium: the pathologists’ perspective” in a recent issue of the International Journal of Molecular Sciences. Endometriosis and adenomyosis are well-known entities as…

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The effect of hormone therapy after surgical menopause on endometriosis recurrence

The effect of hormone therapy after surgical menopause on endometriosis recurrence By Selma Oransay

Definitive surgery for severe and advanced endometriosis is hysterectomy with bilateral oophorectomy, which may cause vasomotor symptoms, sleep deprivation, mood change, and dyspareunia in the patients. Furthermore, after the surgical removal of the ovaries, the sudden drop in estrogens causes…

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Does Surgery Improve the Digestive Symptoms of Endometriosis?

Does Surgery Improve the Digestive Symptoms of Endometriosis? By Özge Özkaya

Women with deep infiltrating endometriosis involving the bowels have the most significant improvement in gastrointestinal symptoms following surgery. This is according to the findings of a comparative retrospective study in almost 1,500 women.  “Women with severe bowel symptoms and deep…

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Life quality improves after colorectal endometriosis operation even when the gastrointestinal symptoms persist

Life quality improves after colorectal endometriosis operation even when the gastrointestinal symptoms persist By Bahar Yuksel

Colorectal endometriosis represents a catastrophic picture for patients, and the treatment mostly requires difficult operative techniques. The life quality improvement ratios are important before deciding on an operation. In the study conducted by Horace Roman et al, the life quality…

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Pharmacological Therapy for Endometriosis Pain

Pharmacological Therapy for Endometriosis Pain By Eylül GÜN

The negative effects of endometriosis on women’s quality of life are indisputable. Women who suffer from endometriosis might have to deal with problems in many aspects such as psychological, sexual, social, and economic. Pain which is one of the most…

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Environmental factors play a role in the development of endometriosis

Environmental factors play a role in the development of endometriosis By Hale Goksever Celik

The proposed mechanisms underlying the development of endometriosis may be classified into three groups: in-situ theory, implantation theories, and induction theories. Genetic, hormonal, environmental, and lifestyle-related factors are also involved as no mechanism is solely responsible for endometriosis development. Although there are…

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The new Endometriosis Surgical Complexity Classification: AAGL 2021

The new Endometriosis Surgical Complexity Classification: AAGL 2021 By Selma Oransay

Multiple endometriosis categorizations have been approved in the recent forty years. The American Fertility Society proposed ASRM with a desire to score the impact of the endometriosis in 1996,  which was updated several times later (rASRM), to predict infertility after laparoscopic operations. For…

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How much are the women with endometriosis aware of their symptoms?

How much are the women with endometriosis aware of their symptoms? By Eylül GÜN

Endometriosis is a debilitating disease from the start. It is not easy to diagnose and there is still not a non-invasive gold-standard diagnostic method despite too much effort. Its effects on the quality of life of patients cannot be ignored.…

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Dietary adjustments do not increase the quality of life of women with endometriosis.

Dietary adjustments do not increase the quality of life of women with endometriosis. By Özge Özkaya

Even though dietary changes do not seem to increase patients’ quality of life, they lead to a perceived reduction in symptoms. No specific adjustment in the diet increases the quality of life of women with endometriosis, according to a new…

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Inflammatory and genetical background of endometriosis may yield new therapeutic approaches

Inflammatory and genetical background of endometriosis may yield new therapeutic approaches By Nasuhi Engin Aydin

Elisa Giacomini and colleagues from medical centers in Milan, Italy have published their review manuscript on the inflammatory and genetical pathogenetic background of endometriosis in a recent issue of  “International Journal of Molecular Sciences”, suggesting also new therapeutic approaches. The inflammatory…

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It is "pain" that causes sleep disturbances and fatigue in endometriosis patients

It is By Bahar Yuksel

Endometriosis has been studied previously about its effects on quality of life and the possible effects on sleeping periods. The study conducted by Federica Facchin et al. questioned the reason for endometriosis to cause sleep disturbance. The authors have divided…

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How does adenomyosis affect IVF outcomes?

How does adenomyosis affect IVF outcomes? By Hale Goksever Celik

Adenomyosis is defined as the localization of endometrial tissue in the muscle layer of uterus. Several theories have been proposed to explain the reasons of adenomyosis-associated infertility including uterine dysperistalsis, abnormal transportation of sperm in the uterine cavity, and embryo…

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Green tea as a therapeutic agent in endometriosis

Green tea as a therapeutic agent in endometriosis By Eylül GÜN

Tea is among the most consumed beverages all around the world. It has many kinds which originate from the same plant “Camellia sinensis” but differ in color after the fermentation process. Green tea is the one produced right after the…

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Molecular alterations in endometriosis pathogenesis

Molecular alterations in endometriosis pathogenesis By Eylül GÜN

Endometriosis has been in our lives for decades, however little is known about its pathogenesis making it hard to diagnose and manage. A review study conducted by Balasubramanian et al. from India reveals all the characteristics and the underlying conditions…

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Phytoestrogens could have promising effects in endometriosis management

Phytoestrogens could have promising effects in endometriosis management By Nasuhi Engin Aydin

Dr. Bartiromo and associates from Milan, Italy published a systematic review on phytoestrogens and endometriosis in the periodical “Nutrients”. Endometriosis has features of chronic inflammation based on uncontrolled hormonal response and immune-mediated dysfunctions. Estrogens are endocrine and paracrine agents that could yield…

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Complex Relation Between Body mass index and endometriosis

Complex Relation Between Body mass index and endometriosis By Selma Oransay

This research aimed to find the relationship between BMI and endometriosis especially related to surgical phenotype and lesion location. An observational cohort study was led by  Holdsworth-Carson et al, from Australia. The article was recently published in "RBMO" . Many earlier studies report…

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Urinary Function Alterations after Surgery for Deep Endometriosis.

Urinary Function Alterations after Surgery for Deep Endometriosis. By Selma Oransay

Laparoscopic surgery is a mainstay therapy for symptomatic patients with DE. Although our findings of improvement in many domains of urinary function are encouraging, postoperative deterioration in urinary function was found for patients with initial normal function. More research is…

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Resveratrol for endometriosis

Resveratrol for endometriosis By Bahar Yuksel

Endometriosis has been studied previously about its inflammatory nature and its tendency for causing macrophage disfunction. In the study conducted by Chunyan Wang et al, the researchers analyzed the effect of a flavonoid, "resveratrol" on endometriosis lesions and the mechanism…

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The comparison of the effect of hemostatic techniques on ovarian reserve during endometrioma cystectomy

The comparison of the effect of hemostatic techniques on ovarian reserve during endometrioma cystectomy By Hale Goksever Celik

The possible negative effect of the surgical excision of endometriomas on the ovarian reserve has brought up the meticulous implementation of the decision for surgical approach. Dr. Raquel Silveria da Cunha Araujo et al, from Brazil, published a study titled as…

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Endometriosis, pelvic inflammatory disease and ovarian cancer

Endometriosis, pelvic inflammatory disease and ovarian cancer By Eylül GÜN

Endometriosis is a locally aggressive and chronic inflammatory disease and it is now known that with various genetic pathways it creates susceptibility to certain cancers, the most common being ovarian cancer. Pelvic inflammatory disease on the other hand creates a…

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Persistence of Chronic Pelvic Pain after Hysterectomy

Persistence of Chronic Pelvic Pain after Hysterectomy By Hale Goksever Celik

Chronic pelvic pain is defined as the "pain in the pelvic area that lasts for 6 months or longer". There are several gynecological, urological, and gastrointestinal reasons for the development of chronic pelvic pain. Nociceptive pain or central sensitization is…

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Improvement of sexual-life quality in patients with endometrioma

Improvement of sexual-life quality in patients with endometrioma By Bahar Yuksel

Endometriosis is a painful disease that affects daily life as well as sexual life quality. In the study conducted by Yalcin Bahat et al, the researchers questioned the effect of periodic use of dydrogesterone on the sexual life quality of patients with…

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Assisted Reproductive Technology Outcomes in Women with and without Endometriosis

Assisted Reproductive Technology Outcomes in Women with and without Endometriosis By Selma Oransay

Endometriosis causes infertility in one-third of patients, while in approximately 25-35% of infertile women, the cause is endometriosis.  The primary interest and the question of Moss et al. from the University of Queensland, Brisbane, Australia was "the differences in the…

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Etiopathogenesis of Endometriosis and Links with Endometrial Cancer

Etiopathogenesis of Endometriosis and Links with Endometrial Cancer By Nasuhi Engin Aydin

Professor Terzic and colleagues from the Medical School of Nazarbayev University, Kazakhstan published their review on the molecular aspects of endometriosis and endometrial cancer in “International Journal of Molecular Sciences”. The etiopathogenesis of endometriosis has remained controversial, with recent studies…

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How to Reduce Pain After Laparoscopic Surgery

How to Reduce Pain After Laparoscopic Surgery By Özge Özkaya

Using humidified warm gas with forced-air warming blanket during laparoscopic surgery resulted in significantly less pain in the recovery room, according to a new study published in the journal "Surgical Endoscopy". In patients with endometriosis, using humidified warm air even…

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“Sirtuin-3” as a novel target in endometriosis pathogenesis

“Sirtuin-3” as a novel target in endometriosis pathogenesis By Eylül GÜN

The energy that is needed for a normal cell function is produced in the mitochondria. While producing this energy, a complex and cyclical process occurs with many proteins and enzymes. Enzymes such as glutamate dehydrogenase and succinate dehydrogenase play important…

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Routine preoperative ureteral stent and complications in Deep Infiltrating Endometriosis

Routine preoperative ureteral stent and complications in Deep Infiltrating Endometriosis By Bahar Yuksel

Deep infiltrative endometriosis is a devastating disease that includes both anterior and posterior compartments, and ureteral infiltration with endometriotic nodules affects 1 to 6% of all deep infiltrative endometriosis patients. In the study conducted by Giulia Borghese et al., the…

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Lead and cadmium exposures of female workers should be reduced as much as possible

Lead and cadmium exposures of female workers should be reduced as much as possible By Nasuhi Engin Aydin

Min-Gi Kim and associates from Korea published their results on the possible effects of lead and cadmium exposure in endometriosis induction and severity in a recent issue of “International Journal of Environmental Research and Public Health”. Endometriosis is an illness…

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Impact of surgery before IVF in infertile women with endometrioma

Impact of surgery before IVF in infertile women with endometrioma By Hale Goksever Celik

Among the women with endometriosis, 30 to 50% are estimated to have infertility. On the contrary, among women who present with infertility, 25 to 50% are estimated to also have endometriosis. Several mechanisms have been proposed to explain the association…

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Small chain fatty acids produced by gut microbiota: Could that be the missing milestone for endometriosis

Small chain fatty acids produced by gut microbiota: Could that be the missing milestone for endometriosis By Bahar Yuksel

Endometriosis is a worldwide problem but still, the underlying mechanism and optimal treatment options are controversial. In the study conducted by Sangappa B Chadchan et al., the researchers investigated the possible relationship between gut microbiota and endometriosis. A study published…

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Ovarian cancer risk in endometriosis and adenomyosis

Ovarian cancer risk in endometriosis and adenomyosis By Eylül GÜN

Through the historical development of the nomenclature for endometriotic tissue found inside and/or outside the uterus, many terminologies have been used. The accepted terminology is still the one introduced by Sampson: “Endometriosis”. “Adenomyosis” also known as “endometriosis interna” which is…

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Uterine cancer risk in "endometriosis" and "adenomyosis"

Uterine cancer risk in By Selma Oransay

Adenomyosis and endometriosis share similar characteristics, and endometriosis is reported to have an increased risk of ovarian cancer. However, the risk of uterine cancer is not clear yet. Hermens and colleagues from Catharina Hospital, from the Netherlands, designed a population-based…

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Endogenous cannabinoids are related to endometriosis pain

Endogenous cannabinoids are related to endometriosis pain By Eylül GÜN

Pain, specifically dysmenorrhea is the most important symptom of endometriosis. Prostaglandins are the main director of the pain process in dysmenorrhea, therefore the mechanisms affecting the prostaglandin metabolism have been studied in order to find a treatment for pain, and found that…

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Dienogest treatment increases the risk of Endometriosis reoperation rate

Dienogest treatment increases the risk of Endometriosis reoperation rate By Selma Oransay

The common and accepted therapy of endometriosis is surgery, however medical treatment such as nonsteroidal anti-inflammatory drugs, gonadotropin-releasing hormone agonists, oral contraceptives and oral progestins are used for either relieving pain or to prevent recurrences and reoperation. Due to bone loss and…

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Body Mass Index and indicators of metabolic syndrome in women with Endometriosis

Body Mass Index and indicators of metabolic syndrome in women with Endometriosis By Hale Goksever Celik

Endometriosis is a disease of reproductive-aged women and has common pathophysiological mechanisms with other chronic health morbidities due to its estrogen-dependent chronic inflammatory background. The changes in the inflammatory components of adipose tissue may have an impact on the quality of…

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Potential new Target to Reduce Endometriosis Pain

Potential new Target to Reduce Endometriosis Pain By Özge Özkaya

The inflammatory mediators, bradykinin, and bradykinin B1 receptor may play a role in the onset of endometriosis-associated pain according to a new study by Chinese researchers. They do so by inducing the prostaglandin signaling pathway. Therefore, targeting these biological pathways…

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Best practice: How to reduce intraoperative bleeding?

Best practice: How to reduce intraoperative bleeding? By Selma Oransay

Although laparoscopic hysterectomy is a popular and common approach for removing benign uterine lesions, some technical steps especially concerning uterine artery closure depend on the surgeon's preference. Uterine artery ligation may be performed either at the uterus level, which is common…

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A new "survey-based" endometriosis diagnostic tool

A new By Bahar Yuksel

Endometriosis is a disease that is diagnosed years after its appearance which causes life quality impairment to patients. It is crucial for the patient to find out the probability of the presence of endometriosis, for applying to healthcare providers before…

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Altered Decidualization and Pregnancy Complications

Altered Decidualization and Pregnancy Complications By Nasuhi Engin Aydin

Dr. Carlo Ticconi and colleagues from Italy published their comprehensive review manuscript “Clinical consequences of defective decidualization” in the June 2021 issue of “Tissue and Cell”. Currently, there has been growing research interest in the study of decidualization, and knowledge of…

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Catching endometriosis from the front line: educating general practitioners

Catching endometriosis from the front line: educating general practitioners By Bahar Yuksel

It should be repetitively pronounced that "endometriosis is very common and it is very important to diagnose it as soon as possible before it causes lifelong damage to women’s lives". The sooner the better concerning the diagnosis, and this is…

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A rare complication of  endometriosis

A rare complication of  endometriosis By Selma Oransay

Morales et al. from the Monterrey School of Medicine, Mexico, reported a case of bowel intussusception in a woman with severe endometriosis to draw attention to this very rare endometriosis complication. The case is a 27 years old young female…

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Not all endometriotic lesions behave similar to the eutopic endometrium

Not all endometriotic lesions behave similar to the eutopic endometrium By Eylül GÜN

The most widely accepted theory of endometriosis pathophysiology is Sampson’s theory of retrograde menstruation which suggests the ectopic lesions undergo the same hormonal and morphological changes as eutopic endometrium during the menstrual cycle. Recent studies have shown that only a…

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Research Identifies New Genes That Could Be Targeted to Treat Endometriosis

Research Identifies New Genes That Could Be Targeted to Treat Endometriosis By Özge Özkaya

Researchers identified three new genes that could help understand the invasiveness of endometriosis. They also identified one new gene that could be related to the recurrence of the disease. These genes may potentially be new therapeutic targets for endometriosis. In…

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Awareness is the first step toward endometriosis treatment

Awareness is the first step toward endometriosis treatment By Dr. Youngran Park

We want to reiterate the importance of endometriosis, by handling the paper entitled "Endometriosis awareness: screaming at the top of our voices" published on April 2021 in the journal “Women & Health”. The Endometriosis Awareness Month of 2021 was a little different,…

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A new "nonhormonal" treatment target in endometriosis

A new By Eylül GÜN

Endometriosis is a chronic inflammatory condition that affects millions of women globally. With pelvic pain being its most common symptom, the cost of the treatment of disease-associated symptoms has been found to be almost as high as type 2 diabetes.…

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The incidence of endometriosis may vary over time according to age, period and cohort

The incidence of endometriosis may vary over time according to age, period and cohort By Hale Goksever Celik

Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. Early diagnosis has importance as endometriosis impairs the quality of life of patients and creates a serious social and economic burden. Fortunately, earlier diagnosis and management of endometriosis becomes…

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A new assessment tool for the multi-dimensional burden of endometriosis

A new assessment tool for the multi-dimensional burden of endometriosis By Eylül GÜN

Endometriosis is a disease that has multiple effects on patients’ lives in various ways. The quality of life, the status of the patient’s relationships, the continuity and productivity in the patient’s education and work environment, and psychological, emotional, and even…

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Ovarian Cancer Survival in the presence of Endometriosis

Ovarian Cancer Survival in the presence of Endometriosis By Özge Özkaya

Women with ovarian cancer and histologically proven endometriosis have longer overall survival compared to those with ovarian cancer but no endometriosis, found a study published in the American Journal of Obstetrics & Gynecology.  “[…] Women diagnosed as having ovarian cancer…

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The added value of transvaginal hydro-laparoscopy for infertile women

The added value of transvaginal hydro-laparoscopy for infertile women By Selma Oransay

The added value of invasive diagnostic laparoscopy has been questioned, postponed by the increased usage of ultrasonography for the evaluation of infertile patients. Gordts et al. from Life Expert Center, Leuven, Belgium have been working on an alternative way called "transvaginal hydro-laparoscopy" to…

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Endometrioma post-surgical-recurrence risk factors

Endometrioma post-surgical-recurrence risk factors By Nasuhi Engin Aydin

Jiang and associates from Dailan Medical University, China published their review manuscript “Risk factors for ovarian endometrioma recurrence following surgical excision: a systematic review and meta‑analysis” in the June 2021 issue of "Archives of Gynecology and Obstetrics". The most common form of endometriosis, "ovarian…

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The role of physical examination and interview in Endometriosis Diagnosis

The role of physical examination and interview in Endometriosis Diagnosis By Bahar Yuksel

Today we know that the most accurate diagnosis of endometriosis necessitates surgery and histopathological examination of the excised lesions. However, many women are misdiagnosed due to various symptoms of endometriosis which mystify gastrointestinal, urinary, and musculoskeletal diseases. Nawrocka-Rutkowska and colleagues…

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Non-invasive Construction of Endometrial Organoids

Non-invasive Construction of Endometrial Organoids By Eylül GÜN

Organoids are 3D culture structures established in vitro and they reflect the aspects of the tissue or the organ they represent. They are seen as important tools in the evaluation of normal development, disease course, and the prediction of the…

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The incidence and prevalence of endometriosis in a United States population-based study .

The incidence and prevalence  of endometriosis in a United States population-based study . By Selma Oransay

To define the accurate incidence and prevalence estimates of endometriosis among nonselected cohorts in the USA, Christ et al. from the Departments of Obstetrics and Gynecology of the University of Washington, Seattle, planned a retrospective cohort study using the electronic KPWA…

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Long noncoding RNAs to predict the endometriosis recurrence

Long noncoding RNAs to predict the endometriosis recurrence By Hale Goksever Celik

Despite extensive research, the exact pathophysiologic mechanism of endometriosis remains unclear; and the absence of non-invasive biomarkers to diagnose endometriosis is still a big problem both for clinicians and patients. The recurrence of endometriosis is another challenge that is difficult…

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Endometriosis & adolescents: Overcoming the diagnostic delay via education

Endometriosis & adolescents: Overcoming the diagnostic delay via education By Eylül GÜN

Although the diagnosis of endometriosis is still not timely even in adults, due to its common under- or misdiagnosis in adolescents, the diagnostic delay may further cause the adolescent women to wait to seek medical treatment.  A group of researchers…

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Chemical Found in Self-Care Products May Be Linked to Endometriosis

Chemical Found in Self-Care Products May Be Linked to Endometriosis By Özge Özkaya

There may be a link between exposure to phthalates and endometriosis according to a new study published in the Journal of Assisted Reproduction and Genetics. Although more research is needed, these findings could be translated into clinical practice according to…

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Transvaginal Ultrasound Accuracy for Uterosacral Ligament, Torus Uterinus and Posterior Fornix Endometriosis

Transvaginal Ultrasound Accuracy for Uterosacral Ligament, Torus Uterinus and Posterior Fornix Endometriosis By Selma Oransay

The accuracy of transvaginal ultrasonography for the diagnosis of deep endometriosis depends on the location. The sensitivity is up to 80% when the lesion is in the rectosigmoid, but it decreases up to 66% for the detection of posterior vaginal…

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The clues for pain and infertility in endometriosis/adenomyosis complex

The clues for pain and infertility in endometriosis/adenomyosis complex By Nasuhi Engin Aydin

Drs. Gruber and Mechsner from Charite University-Berlin, Germany published their comprehensive review on pathophysiological background of endometriosis and adenomyosis in the scientific periodical “Cells”. Chronic pain and fertility problems are the main clinical issue in endometriosis and adenomyosis patients. In order to…

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Technical Facts for the Prevention of Complications After Deep Endometriosis Surgery

Technical Facts for the Prevention of Complications After Deep Endometriosis Surgery By Özge Özkaya

There are no differences in the risk of rectovaginal fistula in women with rectovaginal endometriosis who were managed by a liberal or restrictive policy of preventive stoma according to a study by French researchers published in the Journal of Minimally…

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Non-pharmacological self-care: dietary modifications in women with endometriosis.

Non-pharmacological self-care: dietary modifications in women with endometriosis. By Selma Oransay

The academic interest on the role of diet in endometriosis has grown due to its possible relation with inflammation, estrogenic activity, and menstrual cycles. Multiple dietary strategies and prescriptions are being used to deal with the pelvic pain and gastrointestinal…

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How to measure the length of recto-sigmoid deep endometriosis reliably?

How to measure the length of recto-sigmoid deep endometriosis reliably? By Eylül GÜN

An in-depth assessment is needed when rectosigmoid deep endometriosis is decided to be treated surgically. Surgery carries a lot of risks and it is not always easy to decide which procedure the patient would benefit the most from. Patient-oriented surgical…

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A scoping review proposal for the diagnostic and treatment delay of endometriosis

A scoping review proposal for the diagnostic and treatment delay of endometriosis By Hale Goksever Celik

Women with endometriosis suffer from pain for a prolonged time due to diagnostic and treatment delay which is the most challenging aspect of endometriosis. Cromeens et al, from the USA, published a review entitled “Timing, delays, and pathways to the…

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Strong Geographical Gradient in Endometriosis Incidence Identified

Strong Geographical Gradient in Endometriosis Incidence Identified By Özge Özkaya

The geographical distribution of new endometriosis cases showed a very strong north-south spatial gradient in the highly industrialized Friuli Venezia Giulia region of Italy, according to a new study published in the International Journal of Environmental Research and Public Health. “The cluster of…

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Not just the pain stops but also the bowel function improves after DIE surgery

Not just the pain stops but also the bowel function improves after DIE surgery By Bahar Yuksel

Bowel endometriosis and the techniques to operate it have always been a challenge. The study conducted by Beraldo et al., from Brazil, highlighted the results of an effective nerve-sparing bowel surgery on endometriosis lesions and its long-term effects on patients. The…

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Exploring a bonafide biomarker to predict endometriosis

Exploring a bonafide biomarker to predict endometriosis By Eylül GÜN

Endometriosis is a complex disease affecting many women in the reproductive age group. As it is important to figure out the mechanisms responsible for the disease, it is also crucial to identify biomarkers that can be used in the diagnosis…

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Promising therapeutic results in experimental endometriosis model

Promising therapeutic results in experimental endometriosis model By Nasuhi Engin Aydin

Tiziana Genovese and associates from Italian academic centers reported their pioneering findings in an experimental model of endometriosis administering an anti-tumor agent and glucocorticoid combination, published in the scientific periodical “International Journal of Molecular Sciences”. Endometriosis is a worldwide common disease…

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It is not that simple: endometriomas are almost never alone

It is not that simple: endometriomas are almost never alone By Bahar Yuksel

Endometriomas are the widely and easily diagnosed type of endometriosis. They are usually treated by gynecologic surgeons and are thought to be alone most of the time. The study conducted by Piriyev et al highlighted the coexistence of extraovarian endometriosis…

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Preoperative endometrioma diagnosis

Preoperative endometrioma diagnosis By Selma Oransay

The current clinical experience of gynecologists and radiologists indicates that distinguishing a hemorrhagic cyst from endometriomas or ruptured corpus luteal cysts is compelling. For this reason, chosen criteria that can lead to decisive distinctions are valuable for preoperative identification of endometriomas.…

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Is the presence of nerve fibers in the endometrium associated with endometriosis?

Is the presence of nerve fibers in the endometrium associated with endometriosis? By Eylül GÜN

Endometriosis is a common disease in reproductive women and diagnostic imaging have a limited role in its diagnosis. The gold standard diagnostic method remains to be the histopathological examination of the tissue obtained via laparoscopy. One of its most common…

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Resveratrol, isoflavones and puerarin have favorable in vivo results in endometriosis studies

Resveratrol, isoflavones and puerarin have favorable in vivo results in endometriosis studies By Nasuhi Engin Aydin

Xia Cai and associates from research units located in China published their review article on the relationship between phytoestrogens and endometriosis in the scientific periodical named “Pharmacology”. The great variation in the prevalence of endometriosis raises questions in regard to…

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Endometriosis and Rheumatoid Arthritis, Could There Be a Link?

Endometriosis and Rheumatoid Arthritis, Could There Be a Link? By Özge Özkaya

Patients with endometriosis have a higher risk of rheumatoid arthritis according to a study published in the journal Rheumatology. This finding suggests that rheumatologists should be especially mindful of the possibility of underlying endometriosis when treating women with rheumatoid arthritis.…

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Impact of adenomyosis on sexual life

Impact of adenomyosis on sexual life By Selma Oransay

Considering the similar etiopathogenesis and pain symptoms between adenomyosis and deep infiltrating endometriosis, Alcalde et al. from the Department of Gynecology, University of Barcelona, Spain, aimed to call attention to the presence of potential sexual dysfunction not only in patients with deep…

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Postoperative Opioid use after Robotic operations for endometriosis, compared to non-endometriosis

Postoperative Opioid use after Robotic operations for endometriosis, compared to non-endometriosis By Bahar Yuksel

Endometriosis is a common disease in patients of fertile age, and many patients require surgery. Robotic surgery is accepted as a minimally invasive method in the management of endometriosis and other benign conditions. However, postoperative pain status and the best pain…

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Ureteral endometriosis and its management

Ureteral endometriosis and its management By Eylül GÜN

Urinary tract endometriosis prevalence is hard to determine since almost half of the women with this condition appear asymptomatic. The most common form is bladder endometriosis followed by ureteral endometriosis which is seen more rarely. Ureteral endometriosis is usually located…

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Does hyaluronic acid have a role in endometriosis?

Does hyaluronic acid have a role in endometriosis? By Nasuhi Engin Aydin

Pei-Hsiu Yu and associates from Tainan, Taiwan, published their results of original research on the role of hyaluronic acid in endometriosis formation in a recent issue of  "Taiwanese Journal of Obstetrics and Gynecology". Hyaluronic acid, a glycosaminoglycan protein in the…

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Medical Examination Reduces Anxiety in Women With Suspected Endometriosis

Medical Examination Reduces Anxiety in Women With Suspected Endometriosis By Özge Özkaya

Anxiety levels go down after medical examination in women with suspected endometriosis, found a study by Italian researchers that was published in the Journal of Psychosomatic Research. This was especially pronounced in women who had higher baseline distress and who…

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Analyses of the main classification systems of endometriosis in terms of utrasound, MRI and surgery

Analyses of the main classification systems of endometriosis in terms of utrasound, MRI and surgery By Selma Oransay

Several classifications made by gynecologists, image readers, and radiologists lead to confusion while describing the situation and estimating the progress of endometriosis. Daniela Fischerova team from the Charles University of Prague, Czech Republic, analyzed the main classifications of endometriosis in three…

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Does exercise have an effect on pain perception in women with endometriosis?

Does exercise have an effect on pain perception in women with endometriosis? By Hale Goksever Celik

Endometriosis is an inflammatory disease causing pain symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain, and also infertility. Several medical and surgical treatment options have been developed to improve quality of life of these women. Despite extensive research, the optimal…

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MicroRNAs in the pathogenesis of endometriosis and infertility

MicroRNAs in the pathogenesis of endometriosis and infertility By Eylül GÜN

The gold standard in the diagnosis of endometriosis is laparoscopy and histopathological diagnosis, however search for a non-invasive method has been ongoing. Some biomarkers such as Cancer Antigen 125 have been thought to be useful, but because of their low…

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A hot research topic: macrophage reprogramming for endometriosis treatment

A hot research topic: macrophage reprogramming for endometriosis treatment By Nasuhi Engin Aydin

 Daria Artemova and colleagues from several research institutes of the Russian Federation have published their review on the cellular aspects of endometriosis related to macrophages, particularly emphasizing  promising therapeutic options for the future in "International Journal of Molecular Sciences". Macrophages have…

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The Severity of Pain Does not Predict Endometriosis or its Stage, Study Confirms

The Severity of Pain Does not Predict Endometriosis or its Stage, Study Confirms By Özge Özkaya

The intensity of pain a woman experiences could predict whether or not she would undergo laparoscopic surgery. However, it could not predict whether she has endometriosis or in case she did, the severity of her disease. This is according to…

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The relationship between microbiota and endometriosis

The relationship between microbiota and endometriosis By Eylül GÜN

Endometriosis is a multifactorial and complex disease that results in an inflammatory state. This persistent inflammatory state is known to cause immune dysregulation. In the immunopathogenesis of endometriosis, activated macrophages, increased neutrophils, impaired natural killer cells, altered T-cell differentiation, and…

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Predictors for achieving pregnancy in patients with adenomyosis and endometriosis

Predictors for achieving pregnancy in patients with adenomyosis and endometriosis By Bahar Yuksel

Adenomyosis and endometriosis are benign conditions, however, both situations are associated with deterioration of life quality, a requirement of hospital administrations, and infertility. Laparoscopic surgery is the main treatment option especially for women who desire pregnancy. Shi and colleagues aimed…

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A pictorial overview of abdominal wall endometriosis

A pictorial overview of abdominal wall endometriosis  By Hale Goksever Celik

Abdominal wall endometriosis is the most frequent location of extrapelvic endometriosis, and defined as the presence of ectopic endometrial tissue between the peritoneum and the skin through the abdominal wall. Although obstetric or gynecologic surgical history is indispensable for the…

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New molecular insights in endometriosis pathogenesis

New molecular insights in endometriosis pathogenesis By Nasuhi Engin Aydin

Dr. Rosalba Siracusa and associates from Messina University, Italy, have published their research on cellular pathogenesis of experimental endometriotic lesions in the recent issue of the "International Journal of  Molecular Sciences". Endometriosis is a debilitating chronic estrogen-dependent inflammatory condition and…

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Outcomes of chronic pelvic pain of endometriosis after laparoscopic surgery

Outcomes of chronic pelvic pain of endometriosis after laparoscopic surgery By Selma Oransay

The prevalence of endometriosis is up to 35-50% among patients with pelvic pain. Among several medical and surgical options to relieve chronic pelvic pain, surgical options are the preferred method but this depends on patients' age, fertility desire, and disease…

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How Does Endometriosis Affect Patients Quality of Life?

How Does Endometriosis Affect Patients Quality of Life? By Özge Özkaya

Health-related quality of life is significantly lower in patients with endometriomas or deep infiltrating endometriosis compared to women without the disease. This is according to the results of a recent study in adult Spanish women that was published in the "International…

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Postoperative ovulation induction in infertile women with minimal to mild endometriosis

Postoperative ovulation induction in infertile women with minimal to mild endometriosis By Hale Goksever Celik

Infertility is an important problem that is encountered in 30-50% of women with endometriosis. Several etiopathogenetic mechanisms for the development of reproductive problems in women with endometriosis have been proposed including abnormal peritoneal microenvironment, ovarian dysfunction and/or decreased oocyte quality,…

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Combined contraceptive pills and immune system cells in the endometriotic cyst wall

Combined contraceptive pills and immune system cells in the endometriotic cyst wall By Nasuhi Engin Aydin

Dr. Wanwisa Waiyaput and associates from Mahidol University, Bangkok, Thailand, have published their results on the immune regulatory cells of the surgically resected endometriotic cyst walls in the “Journal of Ovarian Research”. The defective immune response is believed to have…

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Is the information on Facebook groups about endometriosis accurate?

Is the information on Facebook groups about endometriosis accurate? By Eylül GÜN

The use of social media platforms has been increasing day by day. The coronavirus pandemic has attributed to this immensely. Facebook pages and groups are among the most commonly used platforms to share knowledge, seek emotional support, and learn. While…

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Adhesion Barrier Helps After Endometriosis Surgery

Adhesion Barrier Helps After Endometriosis Surgery By Özge Özkaya

An adhesion barrier, named "4DryField® PH" significantly reduced the formation of adhesions following endometriosis surgery, according to a new study by German scientists.  The formation of adhesions following endometriosis surgery is a severe problem that affects 90% of patients. The…

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Women reject using hormonal drugs for endometriosis, an accelerating need for nonhormonal medications

Women reject using hormonal drugs for endometriosis, an accelerating need for nonhormonal medications By Bahar Yuksel

Although the pathophysiology of endometriosis is poorly understood, endocrine drugs are widely used for reducing inflammation and patients’ symptoms. Burla and colleagues aimed to evaluate the patients’ thoughts and expectations about the endocrine drugs which are used in the treatment…

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Managing Persistent Pelvic Pain in a distinct "pain" clinic

Managing Persistent Pelvic Pain in a distinct By Selma Oransay

Persistent pelvic pain is an important problem producing physiological stress and productivity loss during the reproductive period of women. A specific pelvic pain clinic named "Mater Health Persistent Pelvic Pain Clinic" was established in 2017 in a part of the emergency…

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Retinol-binding protein in endometriosis pathogenesis

Retinol-binding protein in endometriosis  pathogenesis By Nasuhi Engin Aydin

Dr. Jae Chul Lee and associates from the Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, have published the recent results of their research on endometriosis regarding the role of retinol-binding protein4…

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What causes distress in women with endometriosis?

What causes distress in women with endometriosis? By Eylül GÜN

Endometriosis is a disease that affects a woman’s life from many different aspects; emotionally, sexually, and physiologically. With the burden of the distress caused by the disease, most women suffer from anxiety and depression. This results in lower self-esteem and…

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The Surgical Management of Endometriosis of the Ureter and Bladder

The Surgical Management of Endometriosis of the Ureter and Bladder By Özge Özkaya

Laparoscopic surgery is feasible and safe to manage endometriosis of the ureter and bladder, according to a new study published in the Journal of Minimally Invasive Gynecology. According to the authors of the study, ureteral resection is more strongly associated…

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Factors affecting complications and the recurrence of operated deep infiltrating endometriosis

Factors affecting complications and the recurrence of operated deep infiltrating endometriosis By Selma Oransay

Deep infiltrating endometriosis is classified as penetrating the endometrial tissues more than 5 mm deep on the peritoneal surface, mainly uterosacral ligament, rectovaginal septum, ovarian fossa, pelvic peritoneum, bowels, ureters, and bladder. Treatment of the disease depends on the need…

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The higher the cyst fluid iron concentration, the more severe the pain symptom for endometrioma

The higher the cyst fluid iron concentration, the more severe the pain symptom for endometrioma By Hale Goksever Celik

Endometriosis usually is encountered in three different forms: superficial peritoneal endometriosis, ovarian cysts (endometrioma) and deep infiltrating endometriosis. Endometrioma can be identified as cystic lesions consisting of dark brown endometrial fluid and are sometimes referred to as "chocolate cysts." The presence…

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Patient- centeredness in endometriosis

Patient- centeredness in endometriosis By Bahar Yuksel

Endometriosis is common in fertile age, and women with endometriosis are suffering from serious symptoms including pelvic discomfort, dysmenorrhea, and infertility. Due to resemblances of endometriosis symptoms with other diseases, most endometriosis patients are faced with delays in diagnosis. To…

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Migraine, endometriosis and plasma "Calcitonin Gene-Related Peptide"

Migraine, endometriosis and plasma By Eylül GÜN

Calcitonin gene-related peptide (CGRP) is a neurotransmitter that takes part in migraine and is now thought to have a role in endometriosis. The role of CGRP is well known in migraine, it is released from neurons during acute attacks and…

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Vulvo- Perineal Endometriosis: From diagnosis to treatment

Vulvo- Perineal Endometriosis: From diagnosis to treatment By Bahar Yuksel

Vulvo- Perineal endometriosis is a very rare condition that should be kept in mind to be diagnosed and treated. Due to its very rare occurrence, most of the information in the literature on vulvo-perineal endometriosis is based on case reports…

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The need for the standardization of diagnostic protocols for "adenomyosis"

The need for the standardization of diagnostic protocols for By Nasuhi Engin Aydin

Dr. Squillace and associates from Brasilian Academic and Health Centers published their paper titled “Adenomyosis and in vitro fertilization impacts- a literature review” in a recent issue of "JBRA Assisted Reproduction". As common gynecological ailment adenomyosis frequently coexists with endometriosis.…

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Endometriosis scar disruption may lead to "spontaneous hemorrhage in pregnancy" and can be life-threatening.

Endometriosis scar disruption may lead to By Selma Oransay

Kollikonda et al from Cleveland Clinic Women's Health Institute, Cleveland, Ohio, US penned a case report about their hemoperitoneum experience during labor, which was recently published in the "Journal of Obstetrics and Gyneaecology Canada". The aim is to warn obstetricians…

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The effect of COVID-19 pandemic on patients with endometriosis

The effect of COVID-19 pandemic on patients with endometriosis By Bahar Yuksel

COVID-19 pandemic and related conditions, including transport restrictions, social isolation, and difficulties accessing the professional health system, affected many women’s healthcare and daily routine. Evans and colleagues investigated the impact of COVID-19 and COVID-19 related parameters on endometriosis patients’ health…

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The genomic linkage between ovarian cancer and endometriosis

The genomic linkage between ovarian cancer and endometriosis By Eylül GÜN

Endometriosis has been proven to be the precursor of ovarian clear cell and endometrioid carcinomas, however, it is not well understood why and how endometriosis goes into malignant transformation.  To address this issue, in their review article, Dr. Yachida and…

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How to predict the complications after laparoscopic bowel resection in women with endometriosis

How to predict the complications after laparoscopic bowel resection in women with endometriosis By Hale Goksever Celik

The endometriotic lesions infiltrating the bowel wall more than 5 mm. are called "deep infiltrating endometriosis". The patients having bowel involvement may have constipation, diarrhea, tenesmus, or rectal bleeding. Surgical management is the main treatment modality to provide benefits on pain, infertility,…

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Endometriosis from the "EVOLUTIONARY" point of view

Endometriosis from the By Nasuhi Engin Aydin

Natalie Dinsdale and associates from the Canadian Simon Fraser University Department of Biological Sciences published a critical review titled “ The evolutionary biology of endometriosis” in a recent issue of the journal “Evolution, medicine and public health”. This review focuses…

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The Communication Gap Between Specialists for Endometriosis Diagnosis and Management

The Communication Gap Between Specialists for Endometriosis Diagnosis and Management By Eylül GÜN

An approach to help the different specialties which work as a team but lack sufficient communication in endometriosis management build better communication was proposed by Leonardi et al. from Australia and Canada in their opinion article which was published in…

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Endometriosis alters women’s self-behavior

Endometriosis alters women’s self-behavior By Bahar Yuksel

Endometriosis diagnosis is given to almost 15% of women of reproductive age. Although endometriosis could be asymptomatic, many women with endometriosis are faced with several symptoms including chronic pelvic pain, dysmenorrhea, dyspareunia, dyschezia, dysuria, and infertility. The wide variability of…

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Evaluation of preoperative risk factors of ureteral endometriosis

Evaluation of preoperative risk factors of ureteral endometriosis By Selma Oransay

Endometriosis affects the urinary tract in 1% to 5.5% of the patients, and among them, bladder involvement is 70-85%, while ureteral involvement alone is 9% to 23%.  Ureteral endometriosis is most commonly unilateral, especially on the left side, usually affecting…

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Promising potential research topic: diagnostic biomarkers for endometriosis

Promising potential research topic: diagnostic biomarkers for endometriosis By Nasuhi Engin Aydin

Dr. Toczek and collegues from the Department of Gynecology, Obstetrics and Oncological Gynecology of Medical University of Silesia in Katowice, Poland, have  published a review paper on possible diagnostic aid of cytokines in endometriosis. This review appears in May issue…

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Endometriosis Surgery Improves Sex Life

Endometriosis Surgery Improves Sex Life By Özge Özkaya

Women who underwent laparoscopic resection surgery to treat their deep infiltrating endometriosis had improved sexual quality of life and health-related quality of life according to a new study published in the Journal of Minimally Invasive Gynecology. These findings are important…

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Myeloid-Derived Suppressor Cells are gaining importance in endometriosis

Myeloid-Derived Suppressor Cells are gaining importance in endometriosis By Nasuhi Engin Aydin

Dr. Wertel and associates from Polish academic centers published their sentimental review paper on the role of "Myeloid-Derived Suppressor Cells" in human diseases, in a recent issue of  Cells. Endometriosis, the most common gynecological disease affecting about 10% of women globally,…

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Postoperative infertility management using Endometriosis Fertility Index in endometriotic women

Postoperative infertility management using Endometriosis Fertility Index in endometriotic women By Selma Oransay

"Endometriosis Fertility Index '' score, described by the World Endometriosis Society in 2017, is a robust score and assists to predict the spontaneous pregnancy rate of women with endometriosis, within 3 years after their operation. Its calculation is possible by patient…

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Could There Be a Relationship Between Endometriosis and the "Restless Leg Syndrome"?

Could There Be a Relationship Between Endometriosis and the By Özge Özkaya

Women with endometriosis have a significantly higher prevalence of restless leg syndrome according to a study published in the scientific journal "Frontiers in Endocrinology". This is the first study highlighting such an association between the two conditions. These findings are important…

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Progestin suppression for endometriosis before IVF

Progestin suppression for endometriosis before IVF By Hale Goksever Celik

“Dienogest is a suitable and safe substitute for GnRHa pretreatment in endometriosis patients”, according to the Khalifa et al., from Egypt. Endometriosis is one of the leading reasons for infertility due to decreased oocyte/embryo quality, fertilizability, tubal function, and aberrant endometrial…

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The endless burden: sexual dysfunction and endometriosis

The endless burden: sexual dysfunction and endometriosis By Bahar Yuksel

The relationship between endometriosis and sexual health in women is one of the hottest topics in obstetrics and gynecology practice. There are some previous reports that investigated the effect of endometriosis on the loss of libido, arousal disorder, orgasmic dysfunction,…

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Endometrial epithelial stem/progenitor cells have links to endometriosis with potential therapeutic research aspects

Endometrial epithelial stem/progenitor cells have links to endometriosis with potential therapeutic research aspects By Nasuhi Engin Aydin

Dr. Cousins with colleagues from Australia and the USA published their review paper on a not well-known subject, the epithelial stem/progenitor cells of the endometrium. This interesting paper is recently published in the scientific journal named "Frontiers in Cell and Developmental…

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What Happens to Endometriosis Patients After Endometriosis Surgery?

What Happens to Endometriosis Patients After Endometriosis Surgery? By Özge Özkaya

Although few patients with endometriosis who undergo a hysterectomy need repeat surgery, up to 25% of them need minor surgery. Around 20% of patients who undergo conservative surgery with ovarian preservation require additional endometriosis surgery. Up to one in three…

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Endometriosis in intestine! Segmental resection or linear nodulectomy?

Endometriosis in intestine! Segmental resection or linear nodulectomy? By Bahar Yuksel

Intestinal involvement of endometriosis is common, and the incidence was defined between 45-56%. Previous studies investigating the role of surgery in the management of intestinal endometriosis reported improvement of life quality in up to 95% of cases following surgery. However,…

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Optimal management of infertility in endometriosis patients

Optimal management of infertility in endometriosis patients By Hale Goksever Celik

Pelvic pain and infertility are the main symptoms of endometriosis patients. Although the pathophysiological mechanism for infertility is not clearly understood, there are several theories explaining decreased fertility potential in women with endometriosis. Ata and Telek, from Koc and Istanbul Universities…

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The association of chronic endometritis, endometriosis and tubal infertility

The association of chronic endometritis, endometriosis and tubal infertility By Selma Oransay

Holzer et al. from the Department of Gynecologic Endocrinology and Reproductive Medicine of  Medical University of Vienna, Austria, set up apilot prospective cohort study to evaluate the relationship between chronic endometritis, infertility and endometriosis. The results of the study were recently…

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Endometriosis and susceptibility to COVID-19

Endometriosis and susceptibility to COVID-19 By Nasuhi Engin Aydin

Dr. Moazzami and associates from Pars Advanced and Minimally Invasive Medical Manners Research Center, Tehran, Iran have published their results on COVID-19 in endometriosis patients in the medical journal named "BMC’s Women’s Health". COVID-19 is still an emerging critical global health problem…

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A gentle touch on nerves affects dyspareunia

A gentle touch on nerves affects dyspareunia By Bahar Yuksel

Endometriosis is a common disorder among women. Previous studies reported endometriosis-related deterioration of the quality of life. Deep dyspareunia is a common symptom of endometriosis and young patients face dyspareunia twice as much. Surgical treatments are alternative to medical therapies in cases…

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Improvement of the quality of life after surgery for deep infiltrating endometriosis.

Improvement of the quality of life after surgery for deep infiltrating endometriosis. By Selma Oransay

Deeply infiltrating endometriosis is the most severe form among the endometriosis types. The required laparoscopic approach is the appropriate excision of endometriotic foci from pelvis, by consideration of failure and side effects of the medical treatments. The specialist endometriosis centers…

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Problems in the treatment of deep infiltrating endometriosis

Problems in the treatment of deep infiltrating endometriosis By Bahar Yuksel

The Deep Infiltrating Endometriosis (DIE) is very aggressive in nature with infiltrating the whole pelvic, colon, rectum, bladder, ureter, and pelvic wall. D’Alterio and colleagues analyzed the advantages and disadvantages of both medical and surgical therapies for DIE. The authors…

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Postoperative long-term estro-progestin therapy for endometrioma

Postoperative long-term estro-progestin therapy for endometrioma By Selma Oransay

After the removal of ovarian endometriomas, the major concern is the high recurrence rate of symptoms and endometriotic cysts. The estimated recurrence rate of endometriomas is up to 50% at 5 years after surgery. To prevent the recurrence, postoperatively long-term…

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Autophagy, Endometrium and Endometriosis

Autophagy, Endometrium and Endometriosis By Dr. Youngran Park

Autophagy, or autophagocytosis, is a self-digestion process by which cells recycle non-functional proteins to repurpose them. Unwanted cellular parts in cytosolic material are first isolated within double-membrane vesicles called the autophagosome, which subsequently fuses with the acidic lysosome. Autophagy is a survival…

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Immune-mediated conditions and endometriosis in adolescents and adults

Immune-mediated conditions and endometriosis in adolescents and adults By Hale Goksever Celik

The most common presenting complaints of endometriosis are mainly pelvic pain and infertility, commonly in relation to the menstrual period. Affected women demand therapy for these symptoms. Immunologic diseases such as autoimmune and/or inflammatory diseases, allergies, asthma, previous mononucleosis infection,…

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Testosterone levels effect embryo implantation rates in patients with endometriosis

Testosterone levels effect embryo implantation rates in patients with endometriosis By Bahar Yuksel

Endometriosis is associated with infertility either causing poor oocyte and embryo qualities or poor endometrial receptivity. The effect of androgen levels on IVF outcomes has been described earlier, but the present study conducted by Ling Huang et assocates is the…

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Fertilization rate and pregnancy outcome in IVF cycles of endometriosis.

Fertilization rate and pregnancy outcome in IVF cycles of endometriosis. By Selma Oransay

Endometriosis affects the pelvic cavity, uterus, ovaries and causes impaired fertility as a result. The chronic inflammatory nature of this disease negatively impacts the oocyte quality, maturation, and fertilization. Obviously, fewer oocytes can be harvested in the IVF cycles of…

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Adenomyosis: accuracy of the diagnostic methods and the synchronism with deep infiltrating endometriosis

Adenomyosis: accuracy of the diagnostic methods and the synchronism with deep infiltrating endometriosis By Nasuhi Engin Aydin

Dr. Alborzi and associates from Shiraz University of Medical Sciences, Iran, have published their comprehensive retrospective research conducted on 3725 patients with clinical symptoms of endometriosis over a period of 3 years, in "Reproductive Sciences" medical journal.  A relationship between…

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Can we measure the severity of endometriosis?

Can we measure the severity of endometriosis? By Dr. Youngran Park

Endometriosis is an enigmatic disease associated with serious morbidity and change in the quality of life. Unfortunately, there is no specific test for the diagnosis of endometriosis. While many markers were evaluated in many research studies for the noninvasive diagnosis…

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Postoperative treatment and pregnancy points to decreased recurrence risk for ovarian endometriosis

Postoperative treatment and pregnancy points to decreased recurrence risk for ovarian endometriosis By Hale Goksever Celik

Endometriosis is a disease most frequently diagnosed in women of reproductive age and negatively affects the quality of life. The most common localization for endometriosis is ovaries with a prevalence of 17-44%. Laparoscopic ovarian cystectomy performed as excision or ablation…

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Endometriosis, ART, fertility preservation

Endometriosis, ART, fertility preservation By Selma Oransay

This review entitled "The impact of endometriosis on the outcome of assisted reproductive techniques: role of fertility preservation" was written by Necula et al. from Gynecology and Obstetrics Unit, Biel, Switzerland, and recently published in the journal "Hormone, Molecular Biology and Clinical…

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Tubo-ovarian abscess and endometriosis

Tubo-ovarian abscess and endometriosis By Bahar Yuksel

A tubo-ovarian abscess is the result of pelvic inflammatory disease in women and the previous reports demonstrated that almost one of the third women with a pelvic inflammatory disease had a tubo-ovarian abscess. The main treatment modalities for tubo-ovarian abscess…

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Pain Sensitization and What Should Be Done About it?

Pain Sensitization and What Should Be Done About it? By Özge Özkaya

Pain sensitization and lumbopelvic impairments are common among women with endometriosis, especially if they have advanced stage disease. This is according to a study by researchers in Spain that was published in the scientific journal "Pain Medicine". The finding underscores the…

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Erastin, Ferroptosis and Endometriosis

Erastin, Ferroptosis and Endometriosis By Dr. Youngran Park

Iron overload has been linked to endometriosis. There are abundant free iron and high oxidation in ectopic lesions, probably due to retrograde menstruation. Interestingly, iron overload in endometriosis activates NF-kB signaling and results in proinflammatory communication. More clear pieces of…

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Cancer, is that a real risk?

Cancer, is that a real risk? By Yu Yu

Endometriosis is non-malignant but shares some similar features with cancer, such as the occurrence of local and distant foci, the ability to resist cell death, and the ability to invade other tissues, causing damage to the organs. Endometriosis also generates…

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Controlled use of bipolar cauterization as an alternative to endometrioma cystectomy

Controlled use of bipolar cauterization as an alternative to endometrioma cystectomy By Hale Goksever Celik

The main symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Ablation or coagulation of the cyst wall following laparoscopic drainage of endometrioma may be an alternative treatment for patients with pregnancy intention. Carbon dioxide, laser, and plasma energy…

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Perineal Endometriosis, How Soon Does it Return After Surgery?

Perineal Endometriosis, How Soon Does it Return After Surgery? By Özge Özkaya

The higher the body mass index (BMI) of a woman during delivery and within one month after delivery, the quicker the symptoms of perineal endometriosis return. This is according to a recent study that appeared in the World Journal of…

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The influence of endometrioma and surgery on ovarian reserve

The influence of endometrioma and surgery on ovarian reserve By Dr. Youngran Park

Women with endometriosis and endometrioma, often have subfertility. These patients present considerable problems for the evaluation of ovarian reserve. One of the well-known ovarian reserve biomarkers is anti-Müllerian hormone (AMH) levels. So far, it was known that the reduction of…

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Selected Blood Inflammatory Biomarkers May Help Identify Endometriosis

Selected Blood Inflammatory Biomarkers May Help Identify Endometriosis By Özge Özkaya

Levels of inflammatory biomarkers in the blood differ between women with endometriosis and those without the disease. Levels of some biomarkers also differ according to the stage of endometriosis. This is according to a new study by Polish scientists published…

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“Advanced gynecological ultrasound” for women with suspected endometriosis

“Advanced gynecological ultrasound” for women with suspected endometriosis By Hale Goksever Celik

Different clinical forms of endometriosis such as superficial endometriosis, endometrioma, and deep infiltrating endometriosis are present. Although no specific diagnostic tool is available for endometriosis, clinical findings, physical examination and imaging including transvaginal ultrasound and MRI are helpful to determine…

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Endometriosis and possible cardiovascular outcomes

Endometriosis and possible cardiovascular outcomes By Selma Oransay

A retrospective population-based cohort study from the Institute of Applied Health Research, University of Birmingham, Birmingham, the UK, investigated the long-term cardiovascular outcomes of women with endometriosis. The study included 279,759 women in total, 20,1% (>56.000) were patients with surgically…

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The effects of endometriosis on life satisfaction.

The effects of endometriosis on life satisfaction. By Bahar Yuksel

Endometriosis is well-known for its debilitating effects on women suffering from it. In the review conducted by Masoumeh Namazi et al, the authors have collected studies searching for the wellbeing of women with endometriosis. They have analyzed 46 studies that…

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Endometrial receptivity after the removal of ovarian endometriotic cysts

Endometrial receptivity after the removal of ovarian endometriotic cysts By Nasuhi Engin Aydin

Mikhaleva and associates from the "Russian Research Institute of Human Morphology" published their results in “Reproductive Sciences” yielding their novel morphological findings of eutopic endometria in patients following surgical excision of endometriotic ovarian cysts. Current therapeutic measures are targeting to…

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Managing the physical and emotional effects of endometriosis

Managing the physical and emotional effects of endometriosis By Hale Goksever Celik

Endometriosis is known to affect 5-10% of the general population, but some women are underdiagnosed due to physical and psychological disability. Due to the symptoms including dysmenorrhea, dyspareunia, chronic pelvic pain and infertility, endometriosis has a negative effect on the quality…

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Environmental to occupational exposure, and possible risk factors for endometriosis.

Environmental to occupational exposure, and possible risk factors for endometriosis. By Selma Oransay

Many objects in daily use are made of plasticizing agents. Studies suggest that chronic exposure to these agents are toxic to reproductive organs and cause metabolic disorders. For example, diethyl phthalate is still in use in cosmetic products.  Caporossi et…

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DNA damage response in eutopic endometria of endometriosis patients

DNA damage response in eutopic endometria of endometriosis patients By Dr. Youngran Park

The DNA damage response (DDR) is a network of cellular pathways that sense, signal, and repair the lesions occurring in DNA. Surveillance proteins that monitor DNA integrity activate the DNA repair pathways in response to DNA damage and try to prevent the generation of potentially deleterious mutations. Endometriosis is an estrogen-dependent…

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Impaired fertility potential in endometriosis patients

Impaired fertility potential in endometriosis patients By Hale Goksever Celik

Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis and sperm movements. Garcia-Fernandez and García-Velasco, from Edinburgh, UK and Madrid, Spain, published a mini-review titled “Endometriosis and Reproduction: What We Have…

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Oxygen deprivation (hypoxia) has a critical role in the pathogenesis and progression of endometriosis

Oxygen deprivation (hypoxia) has a critical role in the pathogenesis and progression of endometriosis By Nasuhi Engin Aydin

Dr. Wan-Ning Li and associates from academic institutions from Taiwan have published their review paper on the role of hypoxia and possible therapeutic outcomes in the medical journal named "Reproduction" recently.  Endometriosis is an important ailment with huge medical and social…

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Endometriosis and the risk of Systemic lupus Erythematosus: A report from Taiwan

Endometriosis and the risk of Systemic lupus Erythematosus: A report from Taiwan By Selma Oransay

Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage that affects mostly women, with an M:F ratio of 1:9. Recent evidence has also shown that endometriosis is…

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The incidence of endometriosis and pelvic pain in transgender man

The incidence of endometriosis and pelvic pain in transgender man By Bahar Yuksel

Transgender operations are quite common all around the world and hysterectomies are performed almost 1 in 5 of this population. The studies conducted until now mostly evaluated operative and postoperative outcomes, but the present research also questioned the preoperative symptoms and…

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Nanomedicines for Endometriosis

Nanomedicines for Endometriosis By Dr. Youngran Park

Scientific research on nanoparticles is intense as they have many potential applications in medicine. Nanomaterials have been widely explored for imaging and treatment of various diseases, especially cancer, over the recent twenty years.  The absence of non-invasive diagnostic tests and…

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The improvement of fertility rate and symptoms of superficial endometriosis following laparoscopic peritoneal stripping

The improvement of fertility rate and symptoms of superficial endometriosis following laparoscopic peritoneal stripping By Selma Oransay

Pain, in the form of diverse entities, including dyspareunia, dysuria, dyschezia, is the main symptom of endometriosis patients. The severity of pain is independent of the extent and the location of the disease, and generally causes a negative impact on…

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Vitamin D supplementation, endometriosis symptoms and metabolic profiles

Vitamin D supplementation, endometriosis symptoms and metabolic profiles By Hale Goksever Celik

Patients with endometriosis suffer from dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. These women are also at higher risk for ovarian and breast cancer, cardiovascular events, and metabolic abnormalities. Several medical and surgical alternatives have been recommended to these patients…

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Cancer risk Evaluation in Korean Endometriosis Cohort

Cancer risk Evaluation in Korean Endometriosis Cohort By Bahar Yuksel

The relationship between endometriosis and cancer has always been challenging. The previous studies revealed an increased risk in endometriosis-associated ovarian cancers regarding the alterations in cancerogenic genes or by the effect of iron and hem coming with retrograde menstruation and…

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A comparison of symptomatology and histopathologic features in surgically resected colorectal endometriosis

A comparison of symptomatology and histopathologic features in surgically resected colorectal endometriosis By Nasuhi Engin Aydin

Dr. Tschan and associates from Feldrich Academic Teaching Hospital, Austria published their retrospective research on patients requiring colorectal surgical resection for endometriosis in European Journal of Medical Research. Bowel endometriosis requiring colorectal surgical resection causes important morbidity. The rectum and…

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Antioxidant therapy for the endometriosis pain

Antioxidant therapy for the endometriosis pain By Selma Oransay

Ts the protective defense mechanism of cells, hence the destruction of balance between oxidants and antioxidants in our body is called "redox imbalance".  The major oxidants are reactive oxygen species (ROS) that are involved in multiple cellular processes by physiologically…

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Ovarian, breast and endometrial cancer coexisting with endometriosis.

Ovarian, breast and endometrial cancer coexisting with endometriosis. By Selma Oransay

The invasive nature of endometriosis results in calling the disease " benign cancer". The transformation of endometriosis to malignancy is rare, but when compared to the general population, the relative risk of developing ovarian cancer is 4.2 times greater especially…

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Self-management and the quality of life in women with endometriosis

Self-management and the quality of life in women with endometriosis By Hale Goksever Celik

Endometriosis symptoms can range from mild to severe. The most common presenting complaints are mainly pelvic pain and infertility. There is no doubt that the physical and mental quality of life of these women is adversely affected. There are several studies…

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The role of hormonal treatment after endometriosis surgery

The role of hormonal treatment after endometriosis surgery By Bahar Yuksel

Postoperative hormonal suppression after endometriosis surgery still does not have a uniform approach. The meta-analysis study conducted by Zakhari et al. aimed to find a significant answer regarding this burden. They analyzed the database systems including MEDLINE, Embase, Cochrane CENTRAL,…

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The association between body size and endometriosis

The association between body size and endometriosis By Irem Onur

Until today there have been few studies investigating body size in childhood and adolescence in women with endometriosis. A new study published recently in the journal Acta Obstetricia et Gynecologica Scandinavica provides further evidence of the associations between endometriosis, body…

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"Speckle sign": a novel transvaginal ultrasound finding for posterior compartment endometriosis

By Nasuhi Engin Aydin

Dr. Balcacer and associates from three medical institutions located in the USA report the results of their retrospective study on deep infiltrating endometriosis utilizing transvaginal ultrasound examination and the proposed  “speckle sign” in the "Journal of Ultrasound Medicine". Pelvic ultrasound…

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Oxidative stress, reactive products, detoxification, endometriosis and pain

Oxidative stress, reactive products, detoxification, endometriosis and pain  By Ellen Tumimbang

Oxidative stress is one factor known to be involved in the pathogenesis, progression, and establishment of endometriosis in women.   During oxidative stress, excess reactive oxygen species as a secondary by-product of lipid peroxidation and reactive aldehyde including 4- hydroxynonenal…

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Live Birth Rate in Women Who Underwent Fresh Embryo Transfer Using Freshly Retrieved Donor Oocytes

Live Birth Rate in Women Who Underwent Fresh Embryo Transfer Using Freshly Retrieved Donor Oocytes By Hale Goksever Celik

One of the important clinical findings in women with endometriosis is reproductive problems. Infertility can be encountered in up to 50% of women with endometriosis and up to 50% of women with infertility can be diagnosed with endometriosis. Several pathophysiologic…

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What is the cause of Dienogest-resistance in patients with endometrioma?

 What is the cause of Dienogest-resistance in patients with endometrioma? By Selma Oransay

Endometriosis may cause infertility in women, leading to adhesions in the pelvis, besides affecting the ovaries. Clinicians concern about the child-bearing desire of their patients when treating them surgically or with hormonal therapy. Dienogest (DNG) is a kind of progestin,…

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Time for noninvasive serum markers for endometriosis diagnosis

Time for noninvasive serum markers for endometriosis diagnosis By Nasuhi Engin Aydin

Dr. Onur Guralp and associates from Germany and Turkey published their results on serum markers predicting endometriosis in the "Journal of Obstetrics and Gynaecology".   Still, in 21st-century medicine, doctors can not diagnose endometriosis using biochemical serum markers. Proposed serum markers…

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Analysis of women with endometriosis-related pain before the multidisciplinary endometriosis care management

Analysis of women with endometriosis-related pain before the multidisciplinary endometriosis care management By Irem Onur

Endometriosis patients are generally treated by a single provider and they frequently report dissatisfaction with care. To decrease diagnostic delays, improve pain management, and promote patient satisfaction, multidisciplinary endometriosis centers emerged. But, baseline data assessing the efficacy of the multidisciplinary…

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High-dose progestin intake and sexual functions in endometriosis patients

High-dose progestin intake and sexual functions in endometriosis patients By Selma Oransay

Dr. Oppenheimer et al. from the Department of Reproductive Medicine and Fertility Preservation of Antoine Beclere University Hospital, Clamart, France, recently published this bi-center observational prospective study in "Acta Obstetrica et Gynecologica Scandinavica". The study was designed to put forth…

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Endometriosis, Fatigue and Productivity

 Endometriosis, Fatigue and Productivity By Ellen Tumimbang

Fatigue is one of the prominent and distressing symptoms of endometriosis-associated with insomnia, depression, pain, occupational stress, and reduced health-related quality of life. Endometriosis-related fatigue causes significant impairments in workplace productivity and daily activities of women with endometriosis. Loss of…

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Is hemoglobin the immune trigger of endometriosis?

Is hemoglobin the immune trigger of endometriosis? By Bahar Yuksel

The role of inflammatory cells in endometriosis has been a popular subject. However, the effects of blood inside the endometriomas were not clarified yet. The study conducted by Kusunoki et al. and published in the "Medical Molecular Morphology" journal has…

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Postoperative pregnancy rate in infertile women with deep infiltrating endometriosis

 Postoperative pregnancy rate in infertile women with deep infiltrating endometriosis By Hale Goksever Celik

Deep infiltrating endometriosis (DIE) is fibrous/muscular infiltration of organs and anatomical structures containing endometrial tissue below the peritoneum regardless of the depth of infiltration. Another definition describes DIE as infiltration of the peritoneum by endometriotic lesions deeper than 5 mm. Pain,…

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Deep endometriosis treatment options based on the patient's decision

 Deep endometriosis treatment options based on the patient's decision By Selma Oransay

Deep endometriosis, defined as endometriotic lesions penetrating deeper than 5 mm into the peritoneum comprise approximately 20% of all endometriosis cases. This invasive disease causes a significant reduction in the quality of life, social participation, and sexual health of affected…

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KEYNOTE: Excision Without Mutilation: It’s Possible! -  Arnaud Wattiez, MD

KEYNOTE: Excision Without Mutilation: It’s Possible! -  Arnaud Wattiez, MD By Özge Özkaya

In his keynote lecture, Dr. Wattiez talks about the pros and cons of endometriosis surgery and the importance of tailoring endometriosis surgery to individual patients.  “Endometriosis is a disease that degrades patient’s wellbeing," Dr. Wattiez says and gives some examples…

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Exploring the Role of Neuropathy in Re-Operative Endometriosis - Marc Possover, MD, PhD

Exploring the Role of Neuropathy in Re-Operative Endometriosis - Marc Possover, MD, PhD By Özge Özkaya

Prof. Possover starts his presentation by summarizing the possible cause of pelvic neuropathy following endometriosis surgery. Pelvic neuropathy is the damage or dysfunction of the pelvic nerve. Prof. Possover explained that this could either be due to incomplete surgery, disease…

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Operative techniques for Deep Endometriosis Surgery - Shaheen Khazali, MD

Operative techniques for Deep Endometriosis Surgery - Shaheen Khazali, MD By Özge Özkaya

In this presentation, Dr. Shaheen Khazali, an endometriosis surgeon specialized in gastrointestinal and urinary tract endometriosis excision and in neuropelveology, talks about the general principles and some techniques for endometriosis surgery focusing on rectovaginal endometriosis. He also describes the "ten…

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Laparoscopic Approach to Rectus Muscle Endometriosis and Inguinal Endometriosis - Ted Lee, MD

Laparoscopic Approach to Rectus Muscle Endometriosis and Inguinal Endometriosis - Ted Lee, MD By Selma Oransay

Rectus muscle endometriosis and inguinal endometriosis are two rare types of endometriosis. Operation room videos of several patients with different rectus muscle endometriosis and inguinal endometriosis are shared during the presentation of Dr. Lee to clarify the methods of the…

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Separation of epithelia and stroma components in endometriosis lesions yields remarkable molecular points - Ie-Ming Shih, MD, Ph.D.

Separation of epithelia and stroma components in endometriosis lesions yields remarkable molecular points - Ie-Ming Shih, MD, Ph.D. By Nasuhi Engin Aydin

The pathologies of adenomyosis and endometriosis are unique among non-malignant gynecological diseases and provide fertile research topics. Ectopic endometrial tissues may have distinct molecular changes distinct from eutopic endometria despite having similar morphology. In this regard, there are intriguing suggestions as…

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Exploring Pelvic Pain: Deep to Ischial Spine Including Pre-Sacral Roots - A. Taner Usta, MD

Exploring Pelvic Pain: Deep to Ischial Spine Including Pre-Sacral Roots - A. Taner Usta, MD By Irem Onur

Chronic pelvic pain is defined as pain in the pelvic area that lasts for 6 months or longer and results in functional or psychological disability or requires intervention and treatment by the American College of Obstetrics and Gynecologists. There are…

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Why Persistent or Recurrent Endometriosis Happens? - Dan Martin, MD

Why Persistent or Recurrent Endometriosis Happens? - Dan Martin, MD By Ellen Tumimbang

The objectives of Dr. Martin in this presentation are to understand the difficulties in recognition of deep and hidden endometriosis, difficulties in recognition of small lesions of micron size, and differentiate the look-alike lesions of endometriosis. He addressed overcoming these…

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Role of Prophylactic Oophorectomy in Endometriosis Patients with Ovarian Cancer History in the family - Farr Nezhat, MD

Role of Prophylactic Oophorectomy in Endometriosis Patients with Ovarian Cancer History in the family - Farr Nezhat, MD By Özge Özkaya

Dr. Nezhat starts his presentation by outlining his objectives, which are to review the basics of cancer genetics, give an overview about endometriosis and ovarian cancer, discuss the pathogenesis of malignant transformation of endometriosis, and talk about the clinical implications…

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Further Evidence that endometriosis is related to tubal or ovarian cancer - Togas Tulandi, MD

Further Evidence that endometriosis is related to tubal or ovarian cancer - Togas Tulandi, MD By Selma Oransay

Most authors suggest an association of endometriosis mainly with clear cell, low-grade serous, and endometrioid ovarian cancer.  But in two large cohort studies, no correlation between them is reported (Olson et al. 2002 and Tseng et al. 2019) Dr. Tulandi…

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Insoluble Dilemma of Adenomyosis: Diagnosis, Management, and Treatment  - Errico Zupi, MD

Insoluble Dilemma of Adenomyosis: Diagnosis, Management, and Treatment  - Errico Zupi, MD By Selma Oransay

The prevalence of adenomyosis has been reported to range from 1% to 70% in different studies. This large range can be explained by the lack of standard diagnostic criteria by imaging modalities or pathological analyses. Sixty-five% of the women with adenomyosis…

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It is time for redefining endometriosis with our contemporary scientific knowledge - Philippe Koninckx, MD, Ph.D.

It is time for redefining endometriosis with our contemporary scientific knowledge -  Philippe Koninckx, MD, Ph.D. By Nasuhi Engin Aydin

Endometriosis defined as endometrium-like tissue outside the uterus has a poorly understood natural history. It is a heterogeneous disease having genetic-epigenetic features with many biochemical changes in the lesions. The Sampson hypothesis of implanted endometrial cells following retrograde menstruation is not…

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Urological Challenges in Endometriosis Surgery - Guenter Noe, MD

Urological Challenges in Endometriosis Surgery - Guenter Noe, MD By Özge Özkaya

In this presentation, Dr. Guenter Noé, Head of Department of Rheilandklinikum Dormagen in Germany talks about endometriosis affecting the urinary tract. Dr. Noé starts by describing the different parts of the urinary tract that can be affected by endometriosis including…

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Implantation failure in endometriosis patients - Jovana Lekovich, MD., PhD.

Implantation failure in endometriosis patients - Jovana Lekovich, MD., PhD. By Hale Goksever Celik

Endometriosis is one of the leading reasons for infertility due to decreased oocyte/embryo quality, fertilization ability, tubal function, and aberrant endometrial receptivity. Whether this failure is caused by oocyte/embryo or eutopic endometrium is one of the investigated topics in endometriosis…

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Fixing holes: prevention and treatment of complications - Jon Einarsson, MD, MPH

Fixing holes: prevention and treatment of complications - Jon Einarsson, MD, MPH By Selma Oransay

Dr. Einarsson shared his operating room video screens during his speech for discussing four major complications (ureter, bladder,  bowel, and vascular) of endometriosis surgery and the ways to repair them. Fixing the ureter damage: Endometriotic nodules may settle on the tract…

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Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD

Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD By Selma Oransay

The removal of endometrioma may affect ovarian reserve because healthy follicles near endometrioma could also be excised during this procedure. Another concern about the ovarian reserve is that it may be already low before the surgery. Anti Mullerian Hormone (AMH)…

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In vitro fertilization protocols in endometriosis patients - Pinar Kodaman, MD., PhD.

In vitro fertilization protocols in endometriosis patients - Pinar Kodaman, MD., PhD. By Hale Goksever Celik

Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis, and sperm movements. Even though the disease stage and presence of endometrioma is negatively correlated with infertility, it is unpredictable which women…

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Could Cosmetics and Personal Care Products Increase the Risk of Endometriosis?

Could Cosmetics and Personal Care Products Increase the Risk of Endometriosis? By Özge Özkaya

The use of cosmetics and personal care products may be increasing the risk of endometriosis according to a study by Spanish researchers that was published in the journal "Environmental Research". This finding suggests that restricting the use of these products may…

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Endometriosis and the sexual relations of the couples

Endometriosis and  the sexual relations of the couples By Selma Oransay

From the viewpoint of endometriotic women, the pain during the penetration is not the only complaint. They also have growing depression and anxiety leading to difficulties with their social and sexual relationship, work, and study. The emotional impact of sub-infertility,…

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A Possible genetic target for endometriosis treatment

A Possible genetic target for endometriosis treatment By Dr. Youngran Park

Mutations in the chromosome remodeling complex SWI/SNF subunit ARID1A were first identified in ovarian clear-cell carcinoma and ovarian endometrioid carcinoma, two endometriosis-associated epithelial ovarian cancer subtypes. ARID1A gene mutations are also observed in deep ovarian and deep infiltrating endometriosis, atypical endometrial…

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The recurrence risk of endometrioma in older age

The recurrence risk of endometrioma in older age By Bahar Yuksel

Ovarian endometrioma is more common in reproductive ages and the recurrence rate is around 20 percent in the first 2 years after the initial surgery. The use of postoperative hormonal therapy is a mutual option to decrease recurrences. The rate…

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Endometriosis involving the Sacral Plexus and Sciatic Nerve

Endometriosis involving the Sacral Plexus and Sciatic Nerve By Irem Onur

Endometriosis rarely involves the sacral and sciatic nerves. A retrospective analysis led by Rouen University Hospital, France and Aarhus University Hospital, Denmark, published in the Journal of Minimally Invasive Gynecology, has evaluated preoperative complaints, intraoperative findings, surgical procedures, and postoperative…

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Endometrioma size and anti-Müllerian hormone levels

Endometrioma size and anti-Müllerian hormone levels By Hale Goksever Celik

Endometriotic lesions are encountered in different locations in the pelvic cavity, including but not limited to the ovaries, the pouch of Douglas, the ureters, the bladder, and the bowel. Cystic endometriosis lesions located in the ovary are called "endometrioma". Endometriomas have…

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Does hysterectomy bring a total relief in patients with endometriosis?

Does hysterectomy bring a total relief in patients with endometriosis? By Bahar Yuksel

There is a common belief that hysterectomy is the last option to relieve the pain in patients with endometriosis by stopping the production of menstrual material. The study entitled "Impact of hysterectomy on analgesic, psychoactive and neuroactive drug use in…

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Pelvic MRI, Endometriosis and Radiologist

Pelvic MRI, Endometriosis and Radiologist By Murat Osman

Endometriosis is a condition whereby ectopic endometrial cells implant themselves onto other structures within the body. Depending on where these lesions are, their size, and if they cause symptoms, surgical intervention may be warranted. Although the gold standard for diagnosing…

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How to unveil the discrepancy regarding the effect of chemicals on the etiology of endometriosis

How to unveil the discrepancy regarding the effect of chemicals on the etiology of endometriosis By Nasuhi Engin Aydin

Kristen Upson from Michigan State University published a review article evaluating research papers on environmental factors effective in endometriosis from an epidemiological perspective in "Current Epidemiology Reports". Endometriosis is a multifactorial disease with anatomical, hormonal, immunological, estrogenic, genetic, epigenetic, and…

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Endometriosis and chronic opioid use

Endometriosis and chronic opioid use By Selma Oransay

The members of the American College of Obstetricians and Gynecologists have declared that gynecologists prescribe opioids after laparoscopic hysterectomy, or for relieving endometriosis pain, although guidelines are not available for when or how to use opioids for the treatment of endometriosis-associated…

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Adolescent endometriosis: Diagnostic clues?

Adolescent endometriosis: Diagnostic clues? By Irem Onur

The rates of dysmenorrhea, dyspareunia, and heavy menstrual bleeding in adolescents showing endometriosis signs on ultrasound are significantly higher compared to those without. This is according to a retrospective observational study recently published in the journal "Fertility and Sterility". The…

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Reduced risk of "small for gestational age baby" following frozen embryo transfer in endometriosis patients

Reduced risk of By Hale Goksever Celik

Infertility is encountered frequently in patients with endometriosis. These women could be managed using assisted reproductive technology (ART) including in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) to achieve pregnancy. However, some adverse obstetric and perinatal outcomes are experienced more…

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Endometrial fluid analysis as a new diagnostic test for endometriosis diagnosis

Endometrial fluid analysis as a new diagnostic test for endometriosis diagnosis By Bahar Yuksel

There is still a huge demand for finding a minimally invasive diagnostic test for endometriosis and yet none has been defined properly. The present study which was conducted in Cleveland Clinic by Natalia C. Llarena et al between March 2017…

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Comparison of diagnostic accuracy of imaging modalities for the deep infiltrating endometriosis

Comparison of diagnostic accuracy of imaging modalities for the deep infiltrating endometriosis By Selma Oransay

The treatment of deeply infiltrated endometriosis (DIE) is usually personalized and the potential success for the available therapeutical options is dependent on early and accurate diagnosis. Laparoscopy is the gold standard for the diagnosis of DIE. Other non-invasive diagnostic methods…

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Endometriosis and adenomyosis could be the “sides of the same coin”.

Endometriosis and adenomyosis could be the “sides of the same coin”. By Nasuhi Engin Aydin

The two common gynecological disorders, namely adenomyosis, and endometriosis are not settled yet, whether they are representing two different entities or different phenotypes of the same ailment. Dr. Maruyama and colleagues from Nara, Japan searched PubMed and Google Scholar electronic…

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Endometriosis and Natural Killer Cell Immunity

Endometriosis and Natural Killer Cell Immunity By Dr. Youngran Park

It is known that approximately 25 to 50% of infertile women have endometriosis, and 30% to 50% of the women with endometriosis have infertility and recurrent pregnancy loss. Previous studies have shown that women suffering endometriosis have abnormal NK cell…

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Magnetic resonance imaging classification for the management of deep pelvic endometriosis

Magnetic resonance imaging classification for the management of deep pelvic endometriosis By Irem Onur

A new study published in the journal "Human Reproduction" reported that operating time, hospital stay, and postoperative complications in patients who underwent surgery for deep endometriosis can be predicted by the MRI. This result may be useful for clinicians to…

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Combination of noninvasive biomarkers in the identification of endometriosis

Combination of noninvasive biomarkers in the identification of endometriosis By Timur Seckin

The combined measurement of urine enolase, serum CA125, and CA19-9 may be an accurate test for the prediction and detection of endometriosis. This is according to a study published in the journal BioMedical Research International. The gold standard for the…

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Patients' opinion about surgical treatment of endometriosis

Patients' opinion about surgical treatment of endometriosis By Selma Oransay

Delayed diagnosis and management of endometriosis and chronic pelvic pain is a major problem in gynecologic practice. Alternatively, providers may feel reluctant to perform surgery although they are aware of treatment options and surgical timing. One possible reason for this…

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Segmental bowel resection could be predicted using MRI in patients with rectal endometriosis

Segmental bowel resection could be predicted using MRI in patients with rectal endometriosis By Hale Goksever Celik

The rectum and recto-sigmoid junction are the preferential localisations of bowel endometriosis. The three main surgical approaches are shaving, disc excision, and segmental resection. It is very important to decide the most appropriate surgical method preoperatively and to plan accordingly. …

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Can a grape ingredient, resveratrol, be the promised warrior to defeat endometriosis?

Can a grape ingredient, resveratrol, be the promised warrior to defeat endometriosis? By Bahar Yuksel

Endometriosis is a chronic estrogen-dependent disorder and has a known relationship with angiogenesis, inflammation, and oxidative stress. Resveratrol is a part of a "polyphenol" compound which are thought to act like antioxidants, protects the body against damage. This compound is normally…

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Dyspareunia and Endometriosis

Dyspareunia and Endometriosis By Irem Onur

Women experience severe pain during intercourse related to endometriosis and this has a significant negative impact on the lives of women. This is according to an American study published in the "Journal of Pain Research". The study included 638 endometriosis…

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Bad bad lipid go away!

Bad bad lipid go away! By Yu Yu

Much like the progression of endometriosis, accumulating evidence suggests that systemic chronic inflammation and oxidative stress can contribute to atherosclerosis. The excess low-density lipoprotein increases inflammatory processes in the arteries, which may result in atherosclerosis. Previous studies have shown that…

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Indocyanine green in endometriosis surgery

Indocyanine green in endometriosis surgery By Selma Oransay

Recently, indocyanine green is well studied and used safely in real-time perfusion to organs or tissues, after taking into consideration its binding capacity to the plasma proteins. The usefulness and the effectiveness of near-infrared camera guided indocyanine green is proved with…

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Osteopontin and Endometriosis

Osteopontin and Endometriosis By Dr. Youngran Park

Although characterized as a benign disease, some properties of endometriosis mimic malignant tissues such as proliferation, cell invasion, and metastasis. Osteopontin, also called secreted phosphoprotein 1, is one of the important molecular targets in cancer progression and metastasis. Osteopontin has been…

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It is time for non-invasive tests for peritoneal endometriosis diagnosis

It is time for non-invasive tests for peritoneal endometriosis diagnosis By Nasuhi Engin Aydin

Maria Szubert with colleagues from Lodz Medical University, Poland, investigated the possibility of potential diagnostic biomarkers in the eutopic endometrial tissue from peritoneal endometriosis patients and published their results in the "Journal of Gynecology Obstetrics and Human Reproduction". Currently, diagnostic…

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Psychometric properties of Endometriosis Health survey-Swedish version

Psychometric properties of Endometriosis Health survey-Swedish version By Hale Goksever Celik

Endometriosis is a chronic estrogen-dependent disease resulting in a broad spectrum of symptoms and signs including dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Additionally, gastrointestinal and urinary systems may be affected by this disease. All of these clinical findings impair…

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Fallopian tube endometriosis

Fallopian tube endometriosis By Bahar Yuksel

Endometriosis affects various tissues including pelvic and extra-pelvic organs. Fallopian tube endometriosis is not a widely studied topic in endometriosis, hence the real incidence is unknown as not all studies evaluate microscopically diagnosed Fallopian tube endometriosis. In the retrospective database…

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Non-coding RNAs and Endometriosis

Non-coding RNAs and Endometriosis By Ellen Tumimbang

Non-coding RNAs may have a fundamental role in the development of endometriosis. Non-coding transcripts have regulatory roles in the expression of protein-coding genes, thus regulate several signaling pathways. Based on their length, these non-coding RNAs are classified into two main classes:…

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Body mass index, the incidence of endometriosis and the severity of dysmenorrhoea

Body mass index, the incidence of endometriosis and the severity of dysmenorrhoea By Timur Seckin

According to a case-control study conducted by researchers from China, there is no association between body mass index (BMI) and the incidence of endometriosis. This finding contrasts with the conventional knowledge that low BMI is a risk factor for endometriosis.…

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An animal model of endometriosis reveals stress related disturbed vitamin D - vitamin D receptor axis

An animal model of endometriosis reveals stress related disturbed vitamin D - vitamin D receptor axis By Nasuhi Engin Aydin

Lopez and colleagues from academic institutions of Puerto Rico published their experimental endometriosis findings on female rats regarding the effect of stress on vitamin D-vitamin D receptor systems and recently published their findings in "Reproductive Sciences". The group previously showed…

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The peculiarity of adolescent endometriosis

The peculiarity of adolescent endometriosis By Selma Oransay

Recent studies showed the prevalence of endometriosis in adolescents with chronic cyclic or acyclic pelvic pain is about 60-70%. Moreover, all stages of endometriosis, including deeply infiltrating endometriosis can be found in this population. Gubbels et al. from the Department…

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The intensity of pelvic pain is higher in endometriosis patients

The intensity of pelvic pain is higher in endometriosis patients By Irem Onur

Silva  J.B. et al., researchers from Brazil, conducted a case-control study to determine the intensity of clinical pain, the average body composition, and the anthropometric markers including the body mass index, the perimeters (waist, abdomen, hip), and the percentage of…

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The more than expected prevalence of endometriosis in patients with Mullerian abnormalities

The more than expected prevalence of endometriosis in patients with Mullerian abnormalities By Bahar Yuksel

Congenital müllerian anomalies resulting in a spectrum of uterine abnormalities are caused by the abnormal embryologic fusion of the müllerian ducts to form a normal uterine cavity.  They are often unrecognized because they are usually asymptomatic. The presence of a uterine…

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Depression and anxiety levels in "in vitro fertilization" patients with endometriosis

Depression and anxiety levels in By Hale Goksever Celik

Endometriosis is a reproductive-aged and estrogen-dependent disease. The most common symptoms of this disease are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility affecting the quality of life in several aspects mainly the psychological domain. In the literature, there are many studies…

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Endometriosis-related obstetrical complications and their outcome

Endometriosis-related obstetrical complications and their outcome By Selma Oransay

Borisova et al. from the Department of Gynecology and Obstetrics of Peoples' Friendship University, Moskow, Russia, and her colleagues from the Center of Perinatal and Reproductive Medicine of University Perugia, Italy, recently published a review of the literature data about…

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Time for reassessment : Laparoscopic surgery and bowel endometriosis

Time for reassessment : Laparoscopic surgery and bowel endometriosis By Nasuhi Engin Aydin

Ferrero and associates from medical centers of Verona and Genoa, Italy, made a comprehensive review covering all aspects of the surgical approach to bowel endometriosis, published their results in "Best Practice & Research Clinical Obstetrics and Gynaecology". Bowel endometriosis is the…

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Cellular communications: Exosomes in Endometriosis

Cellular communications: Exosomes in Endometriosis By Dr. Youngran Park

Exosomes have been reported as cell-to-cell communicators, transfer many molecules such as miRNAs, RNAs, and proteins, and their alteration may cause many disease processes, including endometriosis. Considering the role of exosomes and their cargos in a cell to cell communication as important…

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Predictors of voiding dysfunction after surgery for deep endometriosis

Predictors of voiding dysfunction after surgery for deep endometriosis By Selma Oransay

While surgery for deep endometriosis provides relief and improves the quality of life in symptomatic patients for whom medical therapy has limited effect, it may also create postoperative lower urinary tract dysfunction. Moreover, postoperative voiding dysfunction could affect the quality…

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Sleep Quality, Lifestyle Factors and Endometriosis

Sleep Quality, Lifestyle Factors and Endometriosis By Hale Goksever Celik

Endometriosis does not only affect the patients by dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. An important issue in these patients, like other chronic diseases, is sleep quality. Youseflu et al., from Iran, published a study entitled “Effects of endometriosis…

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Colorectal Deep Endometriosis Resection and Potential Complications

Colorectal Deep Endometriosis Resection and Potential Complications By Murat Osman

A severe clinical form of endometriosis, deeply infiltrating endometriosis (DIE) is characterized by more aggressive endometriotic lesions commonly involving deeper pelvic or gastrointestinal organs. It causes significant quality of life impairment and morbidity and is increasingly associated with infertility. When…

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Factors affecting the quality of life of women with endometriosis

Factors affecting the quality of life of women with endometriosis By Timur Seckin

Results from a new study suggest that the quality of life of women with endometriosis is significantly affected by their confidence to manage pain and their belief in the evolution of their condition. In this study, led by Rees M. et…

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Deep Endometriosis or Recto-uterine Obliteration Without Endometrioma

Deep Endometriosis or Recto-uterine Obliteration Without Endometrioma By Selma Oransay

The diagnostic help of ultrasound is increasing by its ability to diagnose deep infiltrating and rectouterine pouch obliteration in patients who are suffering from chronic pelvic pain. Clinicians are used to evaluating the rectal and parametrial areas of the endometriotic…

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Antioxidant Enzymes in Endometriosis

Antioxidant Enzymes in Endometriosis By Dr. Youngran Park

Recent attention has been focused on the effect of oxidative stress in the development of endometriosis. Especially, there are several studies regarding glutathione peroxidase (GPX), a major enzyme in removing various reactive oxygen species. In the field of infertility, the…

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The advantages of combined vaginal-laparoscopic approach on voiding dysfunction for rectovaginal endometriosis

The advantages of combined vaginal-laparoscopic approach on voiding dysfunction for rectovaginal endometriosis By Irem Onur

The patients with rectovaginal endometriotic nodules with extensive vaginal infiltration who are managed combined vaginal-laparoscopic approach have a lower risk of postoperative bladder dysfunction when compared to surgery via laparoscopy alone. This is according to a manuscript published in the…

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Inhibiting killer on the move

Inhibiting killer on the move By Yu Yu

The three main forms of endometriosis are superficial, ovarian, and deep endometriosis. The latter is defined by the presence of endometriotic nodules that are deeper than 5 mm. Deep endometriosis is considered the most aggressive and is associated with severe…

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Endometrial polyps of patients with and without endometriosis

Endometrial polyps of patients with and without endometriosis By Nasuhi Engin Aydin

Endometrial polyps are benign local overgrowths comprising both glands and the stroma, and are quite common in gynecological practice. Endometriosis patients also commonly have polyps, which have yielded different features than those from patients without endometriosis.  Dr. Jiangand and associates…

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The impact of laser vaporization on reproductive outcomes in women with endometrioma

The impact of laser vaporization on reproductive outcomes in women with endometrioma By Hale Goksever Celik

Despite extensive research, the optimal method for the management of endometriosis still remains unclear. Excisional surgery is claimed with a more favorable outcome than drainage and ablation regarding the recurrence of disease and symptoms. On the other hand, cyst vaporization…

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A Call for Pan-Canadian Collaboration for the Care and Quality of Life of Endometriosis Patients

A Call for Pan-Canadian Collaboration for the Care and Quality of Life of Endometriosis Patients By Timur Seckin

Wahl KJ et al., from Canada, drew attention to the lack of health care for endometriosis patients who are estimated to be 1 million in number in Canada in their recent brief communication report. The delay in the diagnosis, the…

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Bowel surgery for endometriosis

Bowel surgery for endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. The disease harbors various complications. Deep endometriosis involving the bowel is only one aspect of the condition that has variable phenotypic presentations and pathologic subtypes. Knowledge of the short- and long-term risks of the surgical…

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Benefits of Nerve-Sparing Hysterectomy

Benefits of Nerve-Sparing Hysterectomy By Selma Oransay

The retroperitoneal spread of endometriosis or cancer may involve pelvic autonomic nerves situated on the lateral aspects of uterosacral ligaments, vesicouterine ligaments, and medial aspects of parametria. During the conventional open hysterectomy operations, nerve-sparing excision is very difficult, simply because pelvic autonomic nerves…

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Mental stress promotes mice endometriosis

Mental stress promotes mice endometriosis By Bahar Yuksel

Endometriosis is a disease for which pathogenesis and progression are not fully understood. Inflammation is one of the key candidates that might be related to the creation or progression of endometriosis. In the study conducted by Kawakita et al from…

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Diagnosis and treatment of endometriosis in adolescents

Diagnosis and treatment of endometriosis in adolescents By Irem Onur

The belief that dysmenorrhea, the primary symptom of endometriosis, in adolescents is an inevitable condition seen in menstruation as well as unwillingness to perform diagnostic laparoscopy may cause the delay of diagnosis of endometriosis. This is according to a recent…

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Natural history of spontaneous endometriosis in crab-eating monkeys

Natural history of spontaneous endometriosis in crab-eating monkeys By Nasuhi Engin Aydin

Kaori Hayashi and associates from Shiga University of Medical Science, Japan, published their observations on spontaneously occurring endometriosis in crab-eating monkeys in "Tohoku Journal of Experimental Medicine"https://www.jstage.jst.go.jp/article/tjem/251/4/251_241/_pdf/-char/en. The presence of endometrial tissue outside the uterus, i.e., endometriosis is a progressive prevalent…

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Is there a commonality between endometriosis and systemic lupus?

Is there a commonality between endometriosis and systemic lupus? By Murat Osman

Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect many organs including the skin, joints, the central nervous system, and the kidneys. Women of childbearing age and certain racial groups are at increased risk to develop the condition.…

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Patient-centered care in patients with endometriosis

Patient-centered care in patients with endometriosis By Hale Goksever Celik

The women with endometriosis suffer from several symptoms and signs including dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility which have a detrimental effect on their quality of life. Endometriosis is diagnosed with 7-10 years of delay due to the absence…

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Immune cells and endometriosis pain

Immune cells and endometriosis pain By Dr. Youngran Park

Endometriosis is an estrogen-dependent inflammatory disorder in women. This disease leads to dysmenorrhea, pelvic pain, and infertility. The immune reaction is one of the most widely accepted pathologies of endometriosis. Estrogen dysfunction stimulates immune cells in the peritoneal cavity affecting…

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Voiding Dysfunction after Colorectal Surgery for Endometriosis

Voiding Dysfunction after Colorectal Surgery for Endometriosis By Timur Seckin

Postoperative voiding dysfunction is a less frequent complication of rectal shaving than that of discoid excision or segmental resection in patients undergoing colorectal surgery for endometriosis, regardless of its definition. This is according to a meta-analysis conducted by researchers from…

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Prevalence, Risk factors and Management of Bowel Fistula after Rectosigmoid Surgery for Deep Endometriosis

Prevalence, Risk factors and Management of Bowel Fistula after Rectosigmoid Surgery for Deep Endometriosis By Selma Oransay

Bowel fistula is a severe complication after the colorectal endometriosis surgery, but little is known about its prevalence, and reports on large series are lacking. To discuss specific management on colorectal deep endometriosis, Roman et al. conducted a retrospective study…

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Endometriosis prevalence among adolescents with pelvic pain

Endometriosis prevalence among adolescents with pelvic pain By Irem Onur

An updated review conducted by the investigators at EGA Institute for Women's Health, University College London, United Kingdom, in collaboration with Birmingham Women’s and Children’s Foundation Trust of the Institute of Metabolism and Systems Research at the University of Birmingham…

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Hormone Therapy Before Endometriosis Surgery

Hormone Therapy Before Endometriosis Surgery By Yu Yu

Hormonal therapy can be effective for endometriosis, although laparoscopic surgery is required for the frequent drug-resistant symptoms. Laparoscopic surgery can markedly improve endometriosis-associated pain. The administration of GnRH agonist prior to endometriosis laparoscopic surgery may be beneficial to improve surgical…

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Reproductive capacity and recurrence rate after surgery for Stage III/IV endometriosis 

Reproductive capacity and recurrence rate after surgery for Stage III/IV endometriosis  By Bahar Yuksel

If gaining fertility back is the main goal, the surgical removal of endometriosis lesions is globally recognized as first-line therapy. Even though, pre- and postoperative hormone therapy leads to a significant decrease in the spread of the disease measured with the…

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The effects of nutrients on endometriosis-related symptoms

The effects of nutrients on endometriosis-related symptoms By Nasuhi Engin Aydin

A recent literature review from the Netherlands by researchers Emma Huijs and Annamiek Nap, published in "Reproductive Biomedicine Online" puts light on the effects of some nutrients for endometriosis-related symptomatology.  Endometriosis has heterogeneous pathogenesis involving genetic, immunological, environmental, and hormonal…

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Early maternal separation and endometriosis progression in adult mice

Early maternal separation and endometriosis progression in adult mice By Hale Goksever Celik

The quality of life in the women affected by endometriosis depends on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Although several studies have been performed to investigate the underlying pathophysiologic mechanism, it…

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Increased expression of epithelial cell adhesion molecule and its possible role in epithelial-mesenchymal transition in endometriosis.

Increased expression of epithelial cell adhesion molecule and its possible role in epithelial-mesenchymal transition in endometriosis. By Dr. Youngran Park

Endometriosis is an estrogen-dependent disease that functional endometrial tissue exists outside both the uterine cavity and myometrium. The pathogenesis of endometriosis remains unclear and controversial. According to the implantation theory, which is the most well-known, migration and invasion are two…

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Fallopian tubes and endometriosis

Fallopian tubes and endometriosis By Selma Oransay

There are multiple theories to explain the pathogenesis of endometriosis, among which the most popular one is Sampson's retrograde menstruation theory. The role of endometrial stem cells/progenitors are widely studied to support the origin of ectopic lesions in recent decades.…

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Hormone Control Related Genes in Women With Endometriosis

Hormone Control Related Genes in Women With Endometriosis By Ellen Tumimbang

Endometriosis is an estrogen-dependent disease.  The development of endometriosis is stimulated by the specific ability to receive the estrogen that is needed for growth and differentiation of endometrial cells and has numerous biological functions in eutopic and ectopic endometrium. Estrogen…

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Endometriosis Impacts Transgender Adolescents

Endometriosis Impacts Transgender Adolescents By Irem Onur

Shim J.Y. et al, from Boston, Massachusetts retrospectively searched the electronic medical records of transmasculine patients younger than 26 years old who were diagnosed with dysmenorrhea and treated at Boston Children’s Hospital, between January 1, 2000, and March 1, 2020.…

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Clinical characteristics linked to recurrence of ovarian endometrioma

Clinical characteristics linked to recurrence of ovarian endometrioma By Nadire Duru

Endometriosis affects 10-15% of women. Three types of endometriosis are peritoneal, ovarian, and deep infiltrating endometriosis. Ovarian endometriosis is the most common type of endometriosis with a high rate of recurrence. Laparoscopy is the gold standard treatment for endometriosis and…

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The impact of obesity on safety and feasibility of laparoscopic endometriosis surgery

The impact of obesity on safety and feasibility of laparoscopic endometriosis surgery By Hale Goksever Celik

The quality of life in the women affected by endometriosis depends on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. The most common locations of endometriosis are ovary, ovarian fossa, uterosacral ligament, and…

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Adolescent endometriosis

Adolescent endometriosis By Timur Seckin

A recent article, led by experts from Peking Medical Union College, describes the clinical characteristics and postoperative symptoms of adolescent endometriosis. The authors inform that their report, which is published in the "Journal of Pediatric and Adolescent Gynecology", can provide…

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Suggested remedies for endometriosis patients during coronavirus pandemic

Suggested remedies for endometriosis patients during coronavirus pandemic By Nasuhi Engin Aydin

The pandemic of COVID-19 continues to have important effects on endometriosis patients worldwide. Many health care facilities stopped providing surgical management and outpatient appointments are canceled or postponed. Dr. Leonardi from Australia and associates from several countries published their proposals…

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Hysterectomy as a choise of chronic pelvic pain relief in endometriotic women.

Hysterectomy as a choise of chronic pelvic pain relief in endometriotic women. By Selma Oransay

Sandstrom et al. from the Department of Obstetrics and Gynecology of Umea University, Sweden, found a significant and long-lasting reduction in pain symptoms after hysterectomy among women with confirmed endometriosis and recently published their results in "BJOG". The authors performed…

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Occult microscopic endometriosis in clinically negative peritoneum

Occult microscopic endometriosis in clinically negative peritoneum By Irem Onur

Occult microscopic endometriosis may be present in approximately 39% of patients with clinically negative appearing peritoneum undergoing laparoscopy for chronic pelvic pain. This finding is presented in a study published online this month in the International Journal of Gynecology &…

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Cancer-associated mutations and endometriosis

Cancer-associated mutations and endometriosis By Ellen Tumimbang

Endometriosis is thought to benign gynecological disease. However, recent studies compiled in this review paper suggest that spontaneous somatic mutations are driven to occur during the cyclic bleeding resulting in endometriosis tissue undergoing repeated tissue injury and repair. Mutations are…

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Cabergoline or Progesterone not Effective in Rat Model of Endometriosis

Cabergoline or Progesterone not Effective in Rat Model of Endometriosis By Özge Özkaya

Oral treatment with cabergoline or micronized progesterone for four weeks is not effective in the regression of endometriotic implants in a rat model of the disease. This is according to a study published in the "Journal of Investigative Surgery".  Cabergoline…

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Adolescent dysmenorrhea diagnosis and management

Adolescent dysmenorrhea diagnosis and management By Hale Goksever Celik

Endometriosis is usually diagnosed in reproductive-aged women. However, recent literature proved that clinical symptoms of endometriosis are also seen the adolescent girls and young women. Dysmenorrhea, the most common gynecologic complaint among this age group, can develop due to endometriosis.…

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Bone morphogenetic protein and endometriosis

Bone morphogenetic protein  and endometriosis By Nadire Duru

Endometriosis is a chronic disease characterized by the presence of endometrial glands and stroma outside the uterus, associated with several discomforts such as pelvic pain, menstrual disorders, and infertility. Although endometriosis is categorized as a benign lesion, the ectopic endometrial…

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Local inflammation and follicle development in women with ovarian endometriosis

Local inflammation and follicle development in women with ovarian endometriosis By Dr. Youngran Park

Endometriosis, a cause of subfertility, is found in almost 50% of infertile women. The elevated levels of cytokines in the follicular fluid of patients with endometriosis might account for the ovulatory dysfunction. Granulosa cells (GCs) play important roles in follicular…

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Anogenital distance and endometriosis

Anogenital distance and endometriosis By Timur Seckin

Endometriosis may be associated with exposure of the embryo to chemicals called ‘endocrine disruptors’. Exposure to endocrine disruptors can be estimated by measuring the anogenital distance (i.e. the distance between the clitoris and the anus), using a centimeter ruler with…

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International experts commentary for assisted fertility treatment facilities amidst COVID-19

International experts commentary for assisted fertility treatment facilities amidst COVID-19 By Nasuhi Engin Aydin

A multinational and multi-institutional commentary led by Dr. Alviggi from Italy and Dr.Esteves from Brazil has addressed important issues on assisted reproductive technology treatment amid COVID-19 lockdown suggesting remedies in the journal of "Reproductive Biology and Endocrinology" May 2020 issue.…

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The effect of endometriosis on the quality of life

The effect of endometriosis on the quality of life By Hale Goksever Celik

Endometriosis, the disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity, can be diagnosed in the reproductive-aged women with an incidence of 7-15%. However, endometriosis is observed in women with chronic pelvic pain syndrome…

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Endometriosis Diagnosis in White, Black, and Asian Women

Endometriosis Diagnosis in White, Black, and Asian Women By Özge Özkaya

In a commentary published in the "International Journal of Obstetrics and Gynaecology", Drs. Farland and Horne talk about a study by researchers in Canada and the Philippines, which found that black women are less likely, and Asian women are more likely to…

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Diagnosing Deep Endometriosis Using Transvaginal Elastosonography

Diagnosing Deep Endometriosis Using Transvaginal Elastosonography By Murat Osman

Deeply infiltrating endometriosis (DIE) is an advanced form of endometriosis that causes significant morbidity to a large number of women. Early detection of endometriosis is imperative for early treatment and improved outcomes for these patients. Currently, transvaginal ultrasound (TVUS) and magnetic…

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Menstrual Blood Proteins for Endometriosis Diagnosis

Menstrual Blood Proteins for Endometriosis Diagnosis By Ellen Tumimbang

Endometriosis is a gynecological disorder characterized by endometrial tissue outside the uterine cavity. The backflow of menstrual blood from the uterus through the fallopian tubes is thought to be the cause of endometrial tissue growing outside the uterine cavity when…

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A hope for postoperative symptomatic endometriosis therapy

A hope for postoperative symptomatic endometriosis therapy By Irem Onur

A new chapter in the treatment of symptomatic endometriosis patients may begin since new medical approaches including oral GnRH antagonists, selective progesterone receptor modulators, aromatase inhibitors, and peritoneal immune response modulators are being actively evaluated. To date, there was only…

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Opioids use in women with endometriosis, what does it tell us?

Opioids use in women with endometriosis, what does it tell us? By Yu Yu

Endometriosis is a debilitating disease that can cause many painful symptoms such as dysmenorrhea, dyspareunia, infertility, chronic pelvic pain, abdominal pain, and sacral or low back pain. More than half of women diagnosed with endometriosis suffer from chronic pelvic pain.…

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Diagnosis and treatment algorithm for endometriosis

Diagnosis and treatment algorithm for endometriosis By Selma Oransay

Endometriosis is a chronic and progressive disease that affects 25-30% of women between 25-35years, clinicians commonly experience during their gynecologic practice. However, the diagnosis is still late or sometimes incorrect, and this creates severe health problems and worse outcomes. A…

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Endometriosis by Race

Endometriosis by Race By Hale Goksever Celik

Endometriosis is usually diagnosed in reproductive-aged women with an incidence of approximately 10%. The most common presenting symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility in patients with endometriosis. Some risk factors have been identified for the development of…

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Health inequalities in USA

Health inequalities in USA By Timur Seckin

Dr. E. Albert Reece, the vice president for medical affairs at the University of Maryland, Baltimore, specialized in maternal and fetal medicine, wrote on health disparities in the American nation, in Obstetrics and Gynecology News, on the website www.mdedge.com, in June…

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Discrepancies between racial/ethnic groups and choice of hysterectomy procedures

Discrepancies between racial/ethnic groups and choice of hysterectomy procedures By Nasuhi Engin Aydin

Dr. Pollack and associates from Washington University, St.Louis, made multistate research regarding the patient profile in hysterectomies and published their results in the 2019 December issue of "The Journal of Minimally Invasive Gynecology". The most frequently performed nonobstetric surgery in…

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Is oocyte cryopreservation useful for fertility preservation in ovarian endometriosis?

Is oocyte cryopreservation useful for fertility preservation in ovarian endometriosis? By Irem Onur

Women with endometriosis tend to have lower fecundity compared to normal couples. Furthermore,  endometrioma itself may reduce the ovarian reserve by altering ovarian physiology in the surrounding healthy ovarian tissue. The treatment for endometrioma is surgical removal in most cases, however,…

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How Can Racial and Ethnic Disparities Be Reduced Among Women’s Health and Healthcare?

How Can Racial and Ethnic Disparities  Be Reduced Among Women’s Health and Healthcare? By Özge Özkaya

The American College of Obstetricians and Gynecologists published a set of recommendations to help reduce racial and ethnic disparities in women’s health and healthcare and encourage obstetricians, gynecologists, and other health care practitioners to engage in activities to help achieve…

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Endometriosis surgery and future pregnancy complications

Endometriosis surgery and future pregnancy complications By Selma Oransay

Endometriosis is one of the known diseases for infertility in the reproductive period of women. Several studies revealed that endometriosis itself maybe the reason for some unfavorable obstetric outcomes. Localization, the type of endometriotic lesions, and the stage of endometriosis…

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Case-control study to develop a questionnaire for early diagnosis of endometriosis

Case-control study to develop a questionnaire for early diagnosis of endometriosis By Nadire Duru

Endometriosis, which affects 5–10% of women of reproductive age, is a chronic gynecological disease characterized by the presence of endometrial glands and stroma outside the uterus, associated with several discomforts such as pelvic pain, menstrual disorders, and infertility. Ultrasound evaluation…

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The predictors for sexual dysfunction in infertile women with endometriosis

The predictors for sexual dysfunction in infertile women with endometriosis By Hale Goksever Celik

Endometriosis is a disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. Its incidence ranges up to 10% of reproductive-aged women. The most common symptoms in these women are chronic pelvic pain, dyspareunia, and…

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Immune System, Cytokines and Endometriosis

Immune System, Cytokines and Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent chronic disease. Diagnosing endometriosis is difficult because the signs and symptoms vary considerably. Therefore, the discovery of a reliable non-invasive diagnostic biomarker would represent a major advance for the clinical diagnosis of endometriosis.  It has been…

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Neglected needs of endometriosis and infertility patients during COVID-19 pandemic

Neglected needs of endometriosis and infertility patients during COVID-19 pandemic By Timur Seckin

With the global outbreak of the COVID-19, hospitals canceled surgeries and people are afraid of going to hospitals. However, chronic diseases still need to be managed. Rowe H. and Quinlivan J., researchers from Australia, pointed out the neglected needs of…

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Risk Factors Associated with Ureteral Endometriosis

Risk Factors Associated with Ureteral Endometriosis By Özge Özkaya

Patients with severe endometriosis, uterosacral ligament deep involvement with endometriosis lesions of  3 cm in diameter or more, and the presence of previous endometriosis surgery have a significantly higher risk of having ureteral endometriosis. This is according to a study…

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White blood cell neutrophils link to immunosuppressive environment in ovarian endometrioma

White blood cell neutrophils link to immunosuppressive environment in ovarian endometrioma By Yu Yu

Recently the contribution of neutrophils to the pathogenesis of endometriosis has been suggested. Several observations fuelled this suggestion, such as the accumulation of neutrophils in the peritoneal fluid of ovarian endometriosis; neutrophil extracellular traps were found in the peritoneal fluid of…

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Resveratrol for infertility: A frenemy?

Resveratrol for infertility: A frenemy? By Selma Oransay

Ovarian aging is defined by an age-specific decline of the functional ovarian reserve. Female ovarian reserve declines progressively with increasing chronological age. Chronic damage by reactive oxygen species results in deterioration and aging through mitochondrial dysfunction, telomere shortening, cohesion dysfunction,…

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Fatigue from the viewpoint of patients with endometriosis

Fatigue from the viewpoint of patients with endometriosis By Irem Onur

Fatigue, feeling spoonie, is documented as a significant symptom of endometriosis in many studies. Researchers from three different institutions dealing with reproductive health conducted individual interviews with patients reporting moderate to severe endometriosis-related pain to better understand endometriosis-related fatigue and…

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Postmenopausal endometriosis: Is it a rare phenomenon?

Postmenopausal endometriosis: Is it a rare phenomenon? By Hale Goksever Celik

Endometriosis, the estrogen-dependent disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity, is generally diagnosed in the reproductive-aged women. However, recent literature proved that this disease can also be observed in the premenopausal and…

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NAT2 as potential biomarker for the diagnosis and treatment of endometriosis

NAT2 as potential biomarker for the diagnosis and treatment of endometriosis By Nadire Duru

Endometriosis affects 5–10% of women of reproductive age causing several discomforts, pelvic pain, menstrual disorders, ectopic bleeding, infertility, and sometimes even malignant transformation but its etiology remains unclear. Accumulating evidence point a key role for genetic factors and there is…

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miR-92a and progesterone resistance in endometriosis

miR-92a and progesterone resistance in endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. This incidence of this disease is 35% to 50% among those who suffer from chronic pelvic pain and infertility, which has a negative effect on the quality of life and on health. Recent genome-wide associations…

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Endometriosis and Insomnia

Endometriosis and Insomnia By Timur Seckin

There should be more awareness among clinicians for the relationship between insomnia and endometriosis, the study suggests. There needs to be a suspect of endometriosis whenever the clinician faces women of reproductive age with sleep or insomnia-related symptoms. This symptom is…

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Progressive nature of ovarian endometrioma

Progressive nature of ovarian endometrioma By Yu Yu

The effective management of endometriosis requires a proper understanding of how the condition progress as women age, especially for those women with early onset of endometriosis. Several studies have tried to characterize the evolution of endometriosis. Some of the key…

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Improved fusion imaging for the detection of Endometriosis

Improved fusion imaging for the detection of Endometriosis By Murat Osman

This paper studied a new fusion method for magnetic resonance (MR) and ultrasound (US) imaging for the appropriate diagnosis of endometriosis. The diagnosis of endometriosis in patients with a chronic pelvic disease is delayed, due to the disease, patient, and physician-led…

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Appendiceal endometriosis

Appendiceal endometriosis By Selma Oransay

Jeong et al. from the Departement of Surgery, Trinity School of Medicine, Saint Vincent, recently published their interesting appendectomy case in "Hong Kong Medical Journal". In their case, endometriosis inside the cavity of the appendix mimicked appendicitis, the patient submitted…

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Defective “ferroptosis”: a new pathogenetic explanation of endometriosis

Defective “ferroptosis”: a new pathogenetic explanation of endometriosis By Nasuhi Engin Aydin

Dr. Ng and associates from Tufts University School of Medicine, Boston, USA made a comprehensive review of the role of the iron element in the development of endometriotic lesions. Though iron element is essential for cell survival, and its deficiency is important…

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Are endometriosis patients at higher risk of bipolar disorder?

Are endometriosis patients at higher risk of bipolar disorder? By Irem Onur

Endometriosis patients are prone to develop certain psychiatric disorders, including depression and anxiety, as well as bipolar disorder, according to a nationwide population-based cohort study from Taiwan. Bipolar disorder formerly called manic-depression is a chronic mental disorder characterized by unusual changes…

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Maternal body mass index and neonatal outcomes in women with endometriosis

Maternal body mass index and neonatal outcomes in women with endometriosis By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal-like tissue outside the uterine cavity. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of…

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Interleukin-37b inhibits the growth of murine endometriosis-like lesions

Interleukin-37b inhibits the growth of murine endometriosis-like lesions By Nadire Duru

Endometriosis is a chronic gynecological disease that causes chronic pain and infertility in women. Despite continuous efforts and numerous research, there is, ultimately, still much to understand about the pathogenesis of endometriosis. Inflammatory factors including several interleukins have already been…

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Hysterolaparoscopy Plus Assisted Reproduction Improves Fertility in Women with Endometriosis

Hysterolaparoscopy Plus Assisted Reproduction Improves Fertility in Women with Endometriosis By Özge Özkaya

Hysteroscopy and laparoscopic surgery is an effective and reliable therapeutic procedure, confirmed a study published in the "Journal of Clinical Medicine". The approach is even more effective when combined with assisted reproductive techniques such as artificial insemination and in vitro…

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Steroid hormone receptors in endometriosis

Steroid hormone receptors in endometriosis By Yohan Suryo

Therapeutics that target the steroid hormones are the standard treatment for women with endometriosis because steroid hormones play an important role in endometrial physiology and pathogenesis of endometriosis. Examples of these therapeutics include anti-estrogens, estrogen receptor (ER) modulators, progestins, and…

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How should MRI images be obtained for optimal endometriosis detection?

How should MRI images be obtained for optimal endometriosis detection? By Murat Osman

It is well known that the diagnosis of endometriosis for some patients with the chronic pelvic disease is delayed, often for years, due to the disease, patient, and physician-led factors. An area of active study is how ordering physicians can…

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Transvaginal sonography for predicting the distance between rectosigmoid endometriosis and the anal verge

Transvaginal sonography for predicting the distance between rectosigmoid endometriosis and the anal verge By Timur Seckin

For optimal surgery, pre-surgical assessment of the distance between rectosigmoid deep endometriosis lesions and the anal verge (Lesion to Anal Verge Distance-LAVD) is recommended by many specialists. A group of researchers from Norway, Austria, and Australia studied the accuracy of…

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Oxidative stress leads to elevated cytokines, excessive structural damage and angiogenesis

Oxidative stress leads to elevated cytokines, excessive structural damage and angiogenesis By Yu Yu

Endometriosis is characterized by elevated intracellular reactive oxygen species, which is then believed to upregulate inflammatory cytokines. Reactive oxygen species also regulate the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which is closely linked with immune responses.…

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Surgical approach to rectovaginal endometriosis.

Surgical approach to rectovaginal endometriosis. By Selma Oransay

Recto-vaginal endometriosis incidence is estimated at 3.8%-37% among women with endometriosis and when it exists it's a part of deeply infiltrated endometriosis, thus advance stage endometriosis. Raimondo et al. from the Department of Obstetrics and Gynecology of the University of…

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tRNA-derived fragments in ovarian endometriosis?

tRNA-derived fragments in ovarian endometriosis? By Dr. Youngran Park

Endometriosis is an estrogen-dependent mysterious disorder characterized by the presence of endometrium outside the normal location of the uterus cavity. This disease affects approximately 10% of reproductive-aged women and becomes a major reason for infertility in reproductive-aged women and dysmenorrhea…

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Recurrence following surgery for subtypes of endometriosis

Recurrence following surgery for subtypes of endometriosis By Hale Goksever Celik

Endometriosis is a disease identified by the location of endometrial stromal and glandular cells outside the uterine cavity. It is considered as a gynecological disease of reproductive-aged women. Three subtypes of endometriosis are peritoneal endometriosis which defines the endometriotic lesions…

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The efficacy of combined hormonal contraception on pelvic pain in endometriosis patients

The efficacy of combined hormonal contraception on pelvic pain in endometriosis patients By Irem Onur

Chronic pelvic pain, which is experienced by more than 33% of endometriosis patients, constitutes a significant challenge for patients and physicians. A new study that appears in the journal Human Reproduction Open has explored the prevalence of endometriosis patients with a history…

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Antioxidants inhibit autophagy in ectopic endometrial cells

Antioxidants inhibit autophagy in ectopic endometrial cells By Nadire Duru

Factors involved in the development of ectopic endometrium are not well-known, but several reports demonstrate a potential role for the pathophysiological processes including autophagy. Studies show that autophagy plays a significant role in endometriosis but the key mechanisms underlying the…

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A Routine Pelvic Ultrasound Examination Should Include an Evaluation for Endometriosis

A Routine Pelvic Ultrasound Examination Should Include an Evaluation for Endometriosis By Özge Özkaya

Routine pelvic ultrasound examination should be extended beyond the uterus and ovaries into the posterior and anterior pelvic compartments, according to Australian doctors.  With such examinations, deep infiltrating endometriosis nodules can be searched, say the authors, allowing women to be…

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The link between ovarian cancer and endosalpingiosis

The link between ovarian cancer and endosalpingiosis By Timur Seckin

The presence of benign glands lined by tubal-type epithelium in the peritoneum and subperitoneal tissues is called "endosalpingiosis". A recent study that investigates the possible association between endosalpingiosis and ovarian cancer was conducted by Hermens et al., from the Netherlands, and has…

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Non-hormonal chemicals for endometriosis related pain reduction

Non-hormonal chemicals for endometriosis related pain reduction By Nasuhi Engin Aydin

Loi and colleagues conducted a clinical prospective study at the Department of Obstetrics and Gynecology, University of Cagliari, Italy, and published in the journal "International Journal of Women’s Health".  Formation of adhesions and/or interference with the reproductive process endometriosis, severe…

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Fertility conservation in women with endometriosis

Fertility conservation in women with endometriosis By Selma Oransay

Endometriosis affects 10-15% of women in their reproductive period and almost half of them may need Assisted Reproductive techniques to conceive. Moreover, increased malignancy risk is threatening the women with severe endometriosis in addition to their decreased ovarian reserve. Due…

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Imaging of gastrointestinal endometriosis

Imaging of gastrointestinal endometriosis By Murat Osman

Endometriosis is a disease characterized by the ectopic implantation of endometrial tissue to surrounding pelvic and extra-pelvic structures. One frequent site of involvement is the gastrointestinal(GI) tract, which occurs especially among women with deep infiltrating endometriosis. Most cases of GI-involving…

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Fertility preservation protocols in women with endometriosis

Fertility preservation protocols in women with endometriosis By Hale Goksever Celik

Infertility is one of the major symptoms in women with endometriosis. Childbearing at a delayed age is preferred by the majority of women recently who consult for the demand for fertility preservation procedures. There are several techniques for fertility preservation…

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Urgent Need For Building Resilience

Urgent Need For Building Resilience By Timur Seckin

According to Naeem et al.’s article, “Coping with Covid”, Cognitive Behavioral Therapy (CBT) is the ideal intervention tool to increase resilience. Their study has recently been published in "Kyber Medical University Journal". The authors investigate the psychological impact of the Covid-19…

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Early Life Factors for Endometriosis

Early Life Factors for Endometriosis By Dr. Youngran Park

Endometriosis affects approximately 10% of reproductive-aged women. Despite the significant impact, the etiology of endometriosis is still unclear. A recent systematic review of 15 studies of adolescents found that overall 65% of girls undergoing laparoscopic investigation were diagnosed with endometriosis.…

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Long-term Pregnancy Results after Surgical Removal of Endometrioma

Long-term Pregnancy Results after Surgical Removal of Endometrioma By Irem Onur

Sun et al., from China, investigated the pregnancy outcomes and the related factors in patients with endometrioma and stage III-IV endometriosis along with a long-term follow-up postoperatively. Their study has recently been published in the journal named "Advances in Therapy".…

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IL-33 Polarize Peritoneal Macrophages for Endometriosis Growth

IL-33 Polarize Peritoneal Macrophages for Endometriosis Growth By Nadire Duru

M2 type macrophages are the most common type of macrophages found in endometriosis and they enhance the development of endometriosis lesions. The key factors that stimulate macrophages to polarize towards M2 and contribute to the increased endometriosis lesions remain to be…

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The Relationship Between Dyspareunia and Infertility in Endometriosis

The Relationship Between Dyspareunia and Infertility in Endometriosis By Selma Oransay

Wahl et al. from the Center of Pelvic Pain and Endometriosis British Columbia Women's Hospital, Vancouver, Canada studied with endometriotic patients suffering from dyspareunia who were referred to their center and built a cross-sectional study to investigate the relations between…

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All aspects of endometriosis reviewed with focus on modern management

All aspects of endometriosis reviewed with focus on modern management By Nasuhi Engin Aydin

Dr. Chapron and associates from academic centers in France published in Nature Review Endocrinology, a comprehensive review on endometriosis. The article is inclusive of all aspects of endometriosis but especially focuses on the management of the disease with its contemporary status.  Having a…

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Abdominal wall endometriosis: Who is at risk and what causes it?

Abdominal wall endometriosis: Who is at risk and what causes it? By Murat Osman

Endometriosis is a condition that can cause anatomic, hormonal, and inflammatory disturbances that may ultimately result in decreased fertility or infertility. It is a disease process that is defined as ectopic endometrial-like tissue implanting itself to various pelvic and extra…

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Polymorphisms and endometriosis: a systematic review and meta-analyses.

Polymorphisms and endometriosis: a systematic review and meta-analyses. By Yohan Suryo

The symptoms of endometriosis are varied among women and include chronic pelvic pain, infertility, and fatigue. There are no reliable blood tests and medical imaging techniques such as MRI and ultrasound are not always satisfactory. The lack of endometriosis-specific symptoms…

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Does Getting Pregnant Really Help When You Have Endometriosis?

Does Getting Pregnant Really Help When You Have Endometriosis? By Özge Özkaya

Pregnancy has a favorable impact on the volume of deep infiltrating endometriosis lesions according to a study published in the scientific journal "PLoS One". This is the first study that demonstrates such a favorable impact of pregnancy on endometriosis lesion…

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Kisspeptin and its Receptor in the Pathogenesis of Endometriosis

Kisspeptin and its Receptor in the Pathogenesis of Endometriosis By Irem Onur

It is known that matrix metalloproteinases (MMP) may play a role in the pathogenesis of endometriosis. For example, the upregulation of MMP-2 and MMP-9 may enhance the degradation of extracellular matrix proteins, facilitating cell migration and invasion. Kisspeptin (KISS1, also…

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The predictive factors for early spontaneous miscarriage in IVF/ICSI cycles

The predictive factors for early spontaneous miscarriage in IVF/ICSI cycles By Hale Goksever Celik

The most common presenting complaints of endometriosis are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Affected women demand therapy for these symptoms of endometriosis, notably fertility problems. The clinical pregnancy rate has increased up to 60% in assisted reproductive…

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Regulation of Inflammation in Endometriosis

Regulation of Inflammation in Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent and multifaceted gynecological condition. Unfortunately, this disease frequently causes chronic and cyclic pelvic pain. Though there are several treatments are available, there is not an actual cure for this disease. Therefore, the development of new therapy…

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Leiomyomas have similar genetic background with endometriosis

Leiomyomas have similar genetic background with endometriosis By Nasuhi Engin Aydin

This multicenter research conducted in institutions located in the USA and UK published in Nature Communications, October 2019 issue.  Leiomyomata of the uterus are hormone-dependent tumors with an estimated prevalence of about  20-77%. İn several publications. Research in uterine leiomyoma…

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Cycle-related gastrointestinal complaints in reproductive age young women

Cycle-related gastrointestinal complaints in reproductive age young women By Timur Seckin

An analysis of 1-year data on 266 patients who presented to the Clinic and Polyclinic for Gynecology and Reproductive Medicine at Jena University Hospital to undergo surgery for endometriosis and its symptoms was performed by Nicolaous K. et al., a…

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Clinical Evaluation of Endometriosis-Associated Pain

Clinical Evaluation of Endometriosis-Associated Pain By Nadire Duru

Endometriosis has a noteworthy impact on the quality of life of the patients diagnosed with it since it is associated with unpleasant conditions such as endometriosis-associated pain. The diagnosis of endometriosis is not always straightforward because of the varying symptoms…

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The relationship of serum concentrations of neuropilin-1 (NRP-1) and endometriosis

The relationship of serum concentrations of neuropilin-1 (NRP-1) and endometriosis By Irem Onur

Although many serum biomarkers or biomarker panels for endometriosis are evaluated, none of them is exact enough to be used in daily laboratory practice. In a recent study, which has been published in Scandinavian Journal Of Clinical and Laboratory Investigation, Barberic…

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The genetic mutations in uterine adenomyosis

The genetic mutations in uterine adenomyosis By Hale Goksever Celik

Adenomyosis is defined as the localization of endometrial stromal and glandular cells in the myometrium. This disease is a reproductive-aged women disease, like endometriosis. Additionally, adenomyosis is frequently observed together with endometriosis and leiomyomas due to common histological features and…

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How well do providers understand endometriosis?

How well do providers understand endometriosis? By Demet Candaş Green

Endometriosis is a challenging disease no matter what side of the equation you are in, a patient or a provider who cares for patients with the disease. It impacts millions of women worldwide, making it one of the most prevalent…

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Phytotherapy as an alternative endometriosis treatment

Phytotherapy as an alternative endometriosis treatment By Dr. Youngran Park

Endometriosis is an estrogen-dependent gynecological disease that affects 5–10% of women in fertile age. Different therapeutic strategies are available to treat this disease, such as surgery, hormonal therapies, and nonsteroidal anti-inflammatory drugs.  Medical therapy usually consists of different hormonal drugs,…

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Adiposity, endometriosis type and severity

Adiposity, endometriosis type and severity By Selma Oransay

Dr. Jiyoung from the division of Public Health, Department of Family and Preventive Medicine of the University of Utah, planned a prospective cross-sectional study to assess whether there is an inverse relationship between the adiposity and endometriosis. The results of…

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The role of microbiota in the etiopathogenesis of endometriosis

The role of microbiota in the etiopathogenesis of endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. Although many advanced types of research about the etiology, differential diagnosis and treatment have been performed, it still remains an enigmatic disease. Dr. Bedaiwy, a scientist and physician…

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Integrated bioinformatic analysis for endometriosis diagnosis

Integrated bioinformatic analysis for endometriosis diagnosis By Nadire Duru

Endometriosis is considered as a non-malignant disease, but it is associated with several unfavorable conditions including non‑menstrual pelvic pain and infertility. Surgical resection and hormone suppression are common means of treatments; however, several side-effects and the recurrence are not preventable.…

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Preoperative serum CA 125 levels predict the severity of adhesions in endometriosis

Preoperative serum CA 125 levels predict the severity of adhesions in endometriosis By Irem Onur

Lee Y. et al., a group of researchers from Korea evaluated the correlation between preoperative serum markers and pelvic adhesions in endometriosis patients and explored the markers’ clinical value for outcome prediction. They have recently published their study in the…

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Which treatment option improves fertility the most?

Which treatment option improves fertility the most? By Murat Osman

Endometriosis is a condition that causes anatomic, hormonal, and inflammatory disturbances that may ultimately result in decreased fertility or infertility. It is estimated that 30-50% of women with endometriosis suffer from infertility. Thus, the role of surgical, medical, or expectant…

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Endometriosis and Women’s Tendency Towards Blood Clotting

Endometriosis and Women’s Tendency Towards Blood Clotting By Özge Özkaya

Women with ovarian endometriomas have an abnormally increased tendency toward blood clotting, study shows. Researchers think that this is due to the inflammatory nature of endometriosis. So abnormal coagulation parameters could be used to diagnose endometriosis, however, more detailed studies…

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Treatment choices for abdominal wall endometriosis

Treatment choices for abdominal wall endometriosis By Selma Oransay

Welch et.al, from the Department of  Radiology, Mayo Clinic, Rochester, worked with his gynecologist colleagues to underline the current treatment algorithm of abdominal wall endometriosis in Mayo Clinic. Their experience results recently published in the journal "Abdominal Radiology". Abdominal wall…

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The role of acidic ribosomal protein P1 in Endometriosis

The role of acidic ribosomal protein P1 in Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. The disease develops and composed of the ectopic endometrial-like tissue which establishes primarily in the pelvic cavity. Previous findings clearly show that estrogen-related factors are critical for endometriosis development and progression. However, we do have…

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Woman at reproductive age suffering from migraines should consider getting evaluated for endometriosis.

Woman at reproductive age suffering from migraines should consider getting evaluated for endometriosis. By Demet Candaş Green

What do migraine and endometriosis have in common? One can easily answer “pain”. Turns out there are other shared aspects when it comes to these two conditions: both have a high prevalence in women of childbearing age, both suffer from…

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Rare lesions in the pathologic examinations of endometriosis.

Rare lesions in the pathologic examinations of endometriosis. By Selma Oransay

Dr. Glenn McCluggage from the Department of Pathology, Belfast Health, and Social Care Trust, penned a review about selected uncommon variants of endometriosis or benign alterations that may cause difficulties of pathologic diagnosis and provided all related histopathological illustrations in…

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A review of endometriosis in adolescent girls and young women

A review of endometriosis in adolescent girls and young women By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease which is commonly diagnosed in reproductive-aged women. On the other hand, this disease can develop earlier in life due to different etiopathogenetic mechanisms. Especially adolescents who experienced neonatal uterine bleeding are under the risk for…

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Role of miR-141 in endometriosis

Role of miR-141 in endometriosis By Nadire Duru

MicroRNAs (miRNAs) are short (18–24 nucleotides) endogenous non-coding RNAs that regulate a broad range of signaling pathways. They bind to specific sequences resulting in mRNA degradation and protein inhibition. Deregulation of miRNAs is associated with the development of many disease…

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Impact of Genetic Variations in Endometriosis

Impact of Genetic Variations in Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. This disease affects approximately 7% to 10% of reproductive-aged women and causes negative impacts on society. The underlying causes are unclear; therefore, the understanding of this disease remains a major clinical challenge. Endometriosis has a…

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The prevalence and severity of endometriosis today

The prevalence and severity of endometriosis today By Irem Onur

Ghiasi M. et al., a group of researchers from the USA, presented a comprehensive review of the prevalence, incidence, and stage of endometriosis worldwide as reported over the past 30 years. Researchers performed a search in four databases, including PubMed,…

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Worrying signs of Endometriosis on Hysterosalpingography

Worrying signs of Endometriosis on Hysterosalpingography By Murat Osman

Hysterosalpingography (HSG) is an imaging modality that utilizes fluoroscopy in order to evaluate the uterine cavity, fallopian tubes, and adjacent peritoneal cavity by injecting contrast media through the cervical canal. It is an important tool in the work-up of patients who…

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Endometriosis Severity and Complication Risks Following Laparoscopic Surgery

Endometriosis Severity and Complication Risks Following Laparoscopic Surgery By Özge Özkaya

In a research article published in the journal Acta Obstetricia et Gynecologica Scandinavica, researchers at Brigham and Women's Hospital in Boston, Massachusetts suggested that the severity of endometriosis could not be a predictor of the risk of post-operative complications. In…

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The association between endometriosis and ectopic pregnancy

The association between endometriosis and ectopic pregnancy By Hale Goksever Celik

Endometriosis is a chronic inflammatory disease with a broad spectrum of symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain and fertility problems. It has been understood in the light of scientific evidence that endometriosis is also associated with other poor…

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What we should know in managing infertility related to endometriosis?

What we should know in managing infertility related to endometriosis? By Nasuhi Engin Aydin

Dr. Llarena and associates made a comprehensive review of the causes of infertility in endometriosis and adverse effects of surgical procedures in Clinical Medicine Insights: Reproductive Health. Infertility is an important issue in endometriosis patients and about 30-50 % face infertility.…

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Endometriosis and atherosclerotic cardiovascular disease

Endometriosis and atherosclerotic cardiovascular disease By Selma Oransay

Endometriosis and atherosclerotic cardiovascular disease show the same pathologic mechanism in terms of endothelial dysfunction. Tan et al. from the Department of Obstetrics and Gynecology, the University of British Columbia, Vancouver, Canada reviewed the literature aiming to determine whether women…

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CXCR4 or CXCR7 antagonists as novel therapies for endometriosis

CXCR4 or CXCR7 antagonists as novel therapies for endometriosis By Dr. Youngran Park

Endometriosis is a common, estrogen-dependent chronic inflammatory disorder. It affects approximately 5-10% of reproductive-aged women and 20-50% of infertile women. Endometriosis also has a significant social and psychological impact on the lives of women. Despite such a significant burden, there…

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A nonhormonal treatment of endometriosis: Dichloroacetate

A nonhormonal treatment of endometriosis: Dichloroacetate By Irem Onur

In women with endometriosis, peritoneal mesothelial cells show higher glycolysis, lower mitochondrial respiration, decreased enzymatic activity of pyruvate dehydrogenase and increased production of lactate compared to women without the disease. Transforming growth factorβ1 and lactate are elevated in the peritoneal…

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What do Women with Endometriosis Think About the Medical Profession?

What do Women with Endometriosis Think About the Medical Profession? By Özge Özkaya

Failure of surgical treatment, use of the emergency room, and access to complementary healthcare are factors associated with a negative perception of the medical profession in women with endometriosis.  This is according to a study conducted by researchers in British…

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A comprehensive review on the etiopathogenesis of endometriosis

A comprehensive review on the etiopathogenesis of endometriosis By Nasuhi Engin Aydin

Endometriosis, being a heterogeneous disease has a highly complex etiopathogenesis.  A multicenter comprehensive review on this important subject from Italy, Germany, and the USA by Lagana and associates, was recently published in the "International Journal of Molecular Sciences" an open-access journal. Computerized…

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Endometriosis and ovarian reserve

Endometriosis and ovarian reserve By Hale Goksever Celik

Endometriosis is most frequently encountered in reproductive-aged women. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of 25-40%. Although the exact mechanism explaining the association between…

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How to design patient-centered interventions to meet the needs of endometriosis patients

How to design patient-centered interventions to meet the needs of endometriosis patients By Selma Oransay

The treatment of endometriosis is not perfect and necessitates the development of patient-oriented care initiatives. On this basis, patient-related transparent information should be the priority for researchers to find out a way for targeted interventions. Steele et al. from Australia and…

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The Molecular Profile Unique to Endometriosis

The Molecular Profile Unique to Endometriosis By Murat Osman

Endometriosis remains to be a disease entity that is not fully understood. However, recent studies suggest that endometriosis is characterized by several dysregulated biochemical pathways that allow for its survival and growth outside the uterine endometrium. Authors have recently published…

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When to do - and when not to do surgery for endometriosis

When to do - and when not to do surgery for endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. It was estimated to affect about 176 million women in the world and usually causes pelvic pain and infertility. Unfortunately, the current understanding of this disease is very limited. Though there are many remaining questions,…

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Endometriosis in the Urinary Bladder

Endometriosis in the Urinary Bladder By Timur Seckin

A case of bladder endometriosis is reported by Geng JH, from Taiwan, and the paper has been recently published in The New England Journal Of Medicine. The patient was a 38-year-old woman presented to the outpatient urology clinic with complaints…

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Does the Severity of Endometriosis Increase the Risk of Complications Following Surgery?

Does the Severity of Endometriosis Increase the Risk of Complications Following Surgery? By Özge Özkaya

The severity of endometriosis cannot predict the risk of complications after laparoscopy. Instead, the complexity of the surgical procedure itself may increase the risk of complications. This is according to a study published in the journal "Acta Obstetricia et Gynecologica Scandinavica".…

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A new ultrasound subgrouping reveals good clinical correlations in adenomyosis

A new ultrasound subgrouping reveals good clinical correlations in adenomyosis By Nasuhi Engin Aydin

Exacoustos and colleagues from two endometriosis tertiary referral centers in Rome, Italy published their observational, prospective study of the recently proposed transvaginal ultrasonographic scoring system in the "Journal of Minimally Invasive Gynecology". Adenomyosis or “endometriosis interna” is defined as the…

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Recent advances in the diagnosis and treatment of endometriosis

Recent advances in the diagnosis and treatment of endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. The most common complaints of women with endometriosis are pain and fertility problems. Although many advanced types of research about the etiology, differential diagnosis and treatment have been…

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Surgery and the endometriosis associated-pain: A systematic review

Surgery and the endometriosis associated-pain: A systematic review By Selma Oransay

The surgical approach for pelvic pain-related to endometriosis depends on the stage and the type of the endometriotic lesion and ranging from ablation and the excision of the lesions to radical surgery as hysterectomy with removal of ovaries and presacral…

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The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis

The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis By Dr. Youngran Park

Endometriosis is a very common gynecological disorder affecting approximately 10% of reproductive-aged women, and it is known by the abnormal growth of endometrial stroma and glands outside the uterus. Though the pathogenesis of endometriosis is not clearly understood so far,…

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Post-menopausal women diagnosed with Endometriosis and "Imaging"

Post-menopausal women diagnosed with Endometriosis and By Murat Osman

Postmenopausal endometriosis is an underrecognized clinical entity that may present similarly to those of younger patients with endometriosis. Radiologists have an important role in the diagnosis of these patients as they recommend which imaging study should be used to differentiate…

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Medical databases yield 32 published cases of surgically treated liver endometriosis

Medical databases yield 32 published cases of surgically treated liver endometriosis By Nasuhi Engin Aydin

Prodromidou and colleagues from Greece have published a review of surgically diagnosed, histopathologically proven liver endometriosis cases published worldwide, in the journal "Annals of Hepatology". Searching at three electronic medical databases namely, PubMed (1966–2019), Scopus(2004–2019), and Google Scholar (2004–2019) for…

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Hemorrhagic Ascites, Belly-Blood: The cause may be endometriosis!

Hemorrhagic Ascites, Belly-Blood: The cause may be endometriosis! By Timur Seckin

A paper on the presentation of hemorrhagic ascites in endometriosis patients, written by Bernard et al. from the United States and China, was published in the journal Fertility and Sterility. From 1978 to 2016, the authors found only 37 articles, which describe 42…

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Circulating Endometrial Cells

Circulating Endometrial Cells By Yu Yu

Endometriosis is difficult to diagnose because of non-specific symptoms. Currently, there is no biomarker that allows for non-invasive diagnosis of the condition.  Surgical laparoscopy remains the standard for diagnosis. Circulating endometrial cells (CECs) is the lymphovascular spread of endometrial cells.…

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MRI findings predicting the need for colorectal surgical treatment of deep infiltrating endometriosis

MRI findings predicting the need for colorectal surgical treatment of deep infiltrating endometriosis By Irem Onur

LAY SUMMARY: Brusic A. et al., a group of researchers from Australia, conducted a retrospective study to identify the features of deep infiltrating endometriosis on MRI which have an association with colorectal surgical bowel resection. They have recently published their…

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Is deep infiltrating rectosigmoid endometriosis a progressive disease?

Is deep infiltrating rectosigmoid endometriosis a progressive disease? By Demet Candaş Green

This study by Netter at al., published in "Human Reproduction" in November 2019 aimed to assess the risk of progression of deep endometriotic nodules infiltrating the rectosigmoid and to evaluate the influence of continuous amenorrhoea (absence of menstruation) on the development…

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Regret assessment in women under 35 years who underwent hysterectomy

Regret assessment in women under 35 years who underwent hysterectomy By Hale Goksever Celik

Hysterectomy is the most common gynecological operation in women for the management of benign or malign indications. Leiomyomas, menorrhagia, endometriosis, and pain unresponsive to medical treatment can be accepted as the most common indications for hysterectomy. However, hysterectomy, as the…

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Endometriosis features vs Patient age

Endometriosis features vs Patient age By Dr. Youngran Park

Endometriosis, a common gynecological disease, has significant negative impacts on patients’ daily life. Especially in younger women who have yet to achieve pregnancy, effective management should consider the disease progression. Though it is still under debate, some people suggest that…

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Cannabis usage among Australian women with endometriosis

Cannabis usage among Australian women with endometriosis By Irem Onur

Sinclair J. et al., a group of researchers from Australia, conducted a cross-sectional online survey to determine the prevalence, tolerability, and self-reported effectiveness of cannabis in women with endometriosis. This study included 484 women with complete responses. Of all women,…

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Cloverleaf Sign: A new MRI sign for diagnosing DIE

Cloverleaf Sign: A new MRI sign for diagnosing DIE By Selma Oransay

Magnetic resonance imaging provides accurate information for the staging of deeply infiltrating endometriosis, especially when the patient is virgin, obese or has limited transvaginal examinations due to pelvic pain. In this recently published study in Investive Radiology, Harma et al.…

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How Best to Assess Productivity at Work Among Women with Endometriosis?

How Best to Assess Productivity at Work Among Women with Endometriosis? By Özge Özkaya

The health-related productivity questionnaire (HRPQ) is a valid tool to evaluate patient-reported productivity at work and at home among women with endometriosis found a study by U.S. researchers.  This finding is important because it shows that HRPQ can be used…

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Recurrent endometriosis is a real challenge both for the patients and clinicians

Recurrent endometriosis is a real challenge both for the patients and clinicians By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Current medical and surgical treatment options have several limitations including the side effects, costs, risk of recurrence, effects on conception capability. Recurrence is a…

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Endometriosis and Insulin dependent Diabetes Mellitus

Endometriosis and Insulin dependent Diabetes Mellitus By Nasuhi Engin Aydin

Simmen and associates from the University of Arkansas for Medical Sciences, Alabama, published a review article about the co-existence of type 1 diabetes mellitus (T1DM)  and endometriosis, in the recent issue of the "Journal of Endocrinology". Insulin-dependent diabetes or T1DM…

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A new target for the treatment of endometriosis?

A new target for the treatment of endometriosis? By Dr. Youngran Park

Endometriosis affects around 10% of women in reproductive age, estimating more than 176 million women worldwide. Inflammation in the pelvic cavity is very common in endometriosis patients. Therefore, there are high concentrations of cytokines and immune cells in the peritoneal…

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Factors affecting risk of ovarian endometriosis malignancy

Factors affecting risk of ovarian endometriosis malignancy By Özge Özkaya

Getting married when older, having had ovarian endometriosis for longer, giving birth in a shorter time, and other complications in the uterus that are benign may all increase the risk of ovarian endometriosis malignancy. This is according to a study…

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M1 and M2 macrophages in ovarian endometriomas

M1 and M2 macrophages in ovarian endometriomas By Yu Yu

Macrophages play an essential role in the immune response during inflammation and have been implicated in diseases such as inflammatory conditions and cancers. Broadly, macrophages are classified into M1 and M2. The M1 macrophages are pro-inflammatory, and in contrast, the…

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The effect of endometriosis on implantation in women with endometriosis associated infertility

The effect of endometriosis on implantation in women with endometriosis associated infertility By Hale Goksever Celik

One of the most common clinical findings of women with endometriosis is fertility problems. Women with endometriosis often benefit from in vitro fertilization methods to get pregnant. However, whether there is a detrimental effect of endometriosis on in vitro fertilization outcomes…

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A rigorous literature review on endometriosis

A rigorous literature review on endometriosis By Irem Onur

Bulun SE. et al., from Feinberg School of Medicine, Northwestern University, Chicago, conducted a rigorous literature review on endometriosis. This outstanding review by Dr. Bulun et al. addresses the definition, remarkable medical features, clinically useful research findings, prevalence and distribution,…

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Machine Learning Classifiers for Endometriosis

Machine Learning Classifiers for Endometriosis By Dr. Youngran Park

Endometriosis is a complicated gynecological disorder that affects about 176 million women worldwide. It significantly impairs mental and physical quality of life in patients but the etiology is poorly understood. Endometriosis also causes a large economic burden due to loss…

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Transvaginal Ultrasound of Endometriosis

Transvaginal Ultrasound of Endometriosis By Murat Osman

A recent manuscript published by Collins et al. from the Department of Radiology at Penn State Hershey Medical Center aims to review the transvaginal ultrasound (TVUS) evaluation of endometriosis and offer a protocol that is dedicated to the thorough evaluation…

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Increased obstetrical complications after ART therapy in endometriosis patients.

Increased obstetrical complications after ART therapy in endometriosis patients. By Selma Oransay

To examine the impact of endometriosis and adenomyosis on ART therapy, Harada et al. from the Department of Obstetrics and Gynecology of Tottori University, Japan, planned a prospective cohort study and published their results recently in PLoS One.  The study…

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Endometriosis of the Appendix

Endometriosis of the Appendix By Timur Seckin

Endometriosis of the gastrointestinal tract is infrequent, and it rarely involves the appendix. A group of researchers from the United States of America reported a case of a 50-year-old postmenopausal woman with endometriosis in the vermiform appendix presenting as acute…

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Serum anti-Müllerian hormone levels for predicting spontaneous pregnancy after endometriosis surgery

Serum anti-Müllerian hormone levels for predicting spontaneous pregnancy after endometriosis surgery By Hale Goksever Celik

Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Although there are several medical and surgical therapeutic options, the most effective treatment modality has not yet been elucidated.    The main…

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Study Sheds Light on Physiological Processes Associated with Endometriosis

Study Sheds Light on Physiological Processes Associated with Endometriosis By Özge Özkaya

Sensory nerves play an important role in the development of endometriosis as well as fibrosis, confirms a study by Chinese researchers.  A better understanding of physiological processes associated with the development of endometriosis can help researchers devise new ways to…

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Endometriosis as an epigenetically regulated disease

Endometriosis as an epigenetically regulated disease By Dr. Youngran Park

Endometriosis is defined as the abnormal growth of endometrial tissue outside of the uterus. It affects about 10% of reproductive age women resulting in severe pain and infertility. Among various theories of endometriosis pathogenesis, not a single one has successfully…

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Consquences of endometriosis in menopausal period.

Consquences of endometriosis in menopausal period. By Selma Oransay

Marie-Scemama et al. from Foch Hospital, Suresnes, France, referred to endometriosis and menopause which is an actual cruising topic and recently published it in the journal named "Hormone Molecular Biology and Clinical Investigation". Endometriosis a well-known estrogen-dependent disease has three…

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Is there any difference between endometriosis patients with or without obliterated cul-de-sac during laparoscopic hysterectomy?

Is there any difference between endometriosis patients with or without obliterated cul-de-sac during laparoscopic hysterectomy? By Hale Goksever Celik

Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. It is diagnosed in 10% to 15% of reproductive-aged women. Women with endometriosis demand therapy for the most common symptoms, which are…

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A new technique for laparoscopic management of ovarian endometriosis.

 A new technique for laparoscopic management of ovarian endometriosis. By Selma Oransay

To cause a minimal hazardous effect on ovarian reserve during laparoscopic surgery of endometriomas is always a great concern for clinicians. Shaltout et al. from Cairo University, Egypt, examined the effect of "Surgicel" on preventing the recurrence of endometriomas and…

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Which surgical approach for bowel endometriosis?

Which surgical approach for bowel endometriosis? By Irem Onur

A group of researchers from Spain, led by Dr. Alicia Hernández Gutiérrez, conducted a retrospective study to compare postoperative complications and recurrence of three surgical techniques: segmental bowel resection (group I), discoid excision (group II), and rectal nodule shaving (group…

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Perinatal risk factors for endometriosis

Perinatal risk factors for endometriosis By Irem Onur

Gao M. et al., from Sweden analyzed the associations of maternal and birth characteristics with the risk of endometriosis among Swedish women of reproductive age. They have recently published their study in the "International Journal of Epidemiology". The authors conducted…

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New Protein for Endometriosis Diagnosis

New Protein for Endometriosis Diagnosis By Özge Özkaya

A protein called TIMP3 (tissue inhibitor of metalloproteinase-3) could be used for the diagnosis and prognosis (likely course) of endometriosis.  The early diagnosis of endometriosis is of paramount importance because it can help to diagnosis and thus initiate the right…

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Does ovarian endometriosis affect oocyte quality?

Does ovarian endometriosis affect oocyte quality? By Dr. Youngran Park

Endometriosis is a very common gynecological disorder affecting women in their reproductive years. It is reported that patients with endometriosis have reduced implantation and pregnancy rates compared to healthy women. According to the various previous studies, the quality of the…

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How does pregnancy affect endometriosis?

How does pregnancy affect endometriosis? By Hale Goksever Celik

Endometriosis is the localization of endometrial stromal and glandular cells outside the uterine cavity. Pregnancy is offered as a treatment option for patients with endometriosis because it causes atrophy of endometrial cells similar to progesterone treatment. Progesterone predominance during pregnancy,…

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Using social media to raise awareness for endometriosis

Using social media to raise awareness for endometriosis By Demet Candaş Green

Raise your hand if you have used internet or social media to search for information today. We all do, every single day. Whether it is a recipe, biography of a favorite singer, reviews of a new restaurant, or today’s weather,…

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Endometriosis and the quality of life

Endometriosis and the quality of life By Selma Oransay

Recent developments of technics and improvement of skill in the laparoscopic field increased the courage of clinicians to attempt early and multiple diagnostic operations on endometriotic patients. Vanuccini et al. from NEUROFARBA, University of Florence, Florence, Italy recently published their…

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Is there an association between endometriosis and sexual activity during menstruation ?

Is there an association between endometriosis and sexual activity during menstruation ? By Nasuhi Engin Aydin

This recent case-control study with 185 women having endometriosis and  370 women as a control group was conducted in Tebriz University, Iran by Dr. Mollazadeh and associates.  Contemporarily, retrograde menstruation is a valid theory for disseminating endometrial tissue to the…

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Analysis of childless women with endometriosis

Analysis of childless women with endometriosis By Irem Onur

Facchin F. et al., from Italy studied if the beliefs of childless women regarding motherhood, female identity, and infertility affected their psychological health. They have recently published their study in the Journal of Health Psychology. The data of this study were…

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How Long Does it Take to Be Diagnosed with Endometriosis?

How Long Does it Take to Be Diagnosed with Endometriosis? By Özge Özkaya

It takes a median of eight years to reach a diagnosis of endometriosis from when the symptoms of the condition first appear confirmed a new British study. Interestingly, it seems that the earlier the symptoms appear, the later the disease…

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Patients preferences for the treatment of endometriosis-associated pain

Patients preferences for the treatment of endometriosis-associated pain By Hale Goksever Celik

Endometriosis is defined as the location of endometrial stroma and glands outside the uterine cavity. The most common presenting complaints are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility, most of which relate to the menstrual period. Those women affected…

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MicroRNA Inhibitor as an Endometriosis treatment

MicroRNA Inhibitor as an Endometriosis treatment By Dr. Youngran Park

Endometriosis is a well-known estrogen-dependent gynecological disorder. This disease affects approximately 20% to 50% of infertile women and 10% of reproductive-aged women resulting in infertility and pelvic pains.  In order to find endometriosis-specific treatment, various studies have been tried to…

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Adolescent dysmenorrhea and future endometriosis

Adolescent dysmenorrhea and future endometriosis By Selma Oransay

Dysmenorrhoea is typically classified as primary, or secondary due to underlying pathologies like fibroids, endometriosis, adenomyosis or uterine anomalies. Generally, long-term dysmenorrhea is present in endometriotic patient's anamnesis, but until recently, the research to clarify this connection remained retrospective. Knox et…

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Impact of Endometriosis on Embryo Development

Impact of Endometriosis on Embryo Development By Dr. Youngran Park

Endometriosis is a hormone-dependent disorder which affects approximately 10% of women in reproductive age. There are many endometriosis-related problems, but infertility is one of the well-known issues which should be handled and understood. Despite numerous trials, the mechanisms and pathology…

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Clinical trial for the use of oral lactobacillus on endometriosis pain severity

Clinical trial for the use of oral lactobacillus on endometriosis pain severity By Yu Yu

The standard treatment of endometriosis consists of surgery and hormonal based treatment. There is evidence for the efficacy of these types of treatment, although their side effects remain a critical consideration for women. Based on molecular studies, changes in the…

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How to predict complications for endometriosis surgery?

How to predict complications for endometriosis surgery? By Timur Seckin

In a new study co-led by scientists at Sorbonne University, a nomogram is built to better inform patients about the risk of deep endometriosis surgery without bowel involvement. The findings have been published in the European Journal of Obstetrics &…

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Melatonin receptors and their role in endometrial cell proliferation

Melatonin receptors and their role in endometrial cell proliferation  By Hale Goksever Celik

Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Despite extensive research, the exact pathophysiological mechanism and the optimal management of endometriosis still remains unclear. Management of endometriosis should aim to relieve pain,…

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Atherosclerotic cardiovascular disease and endometriosis

Atherosclerotic cardiovascular disease and endometriosis By Nasuhi Engin Aydin

Dr. Omur Taskin and associates from British Columbia, Canada, have recently published a review regarding the potential link between atherosclerotic cardiovascular disease (ASCVD) and endometriosis in The Journal of Minimally Invasive Gynecology. Atherosclerotic cardiovascular disease is the leading cause of…

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Impact of hemostatic techniques used in endometrioma surgery on ovarian function

Impact of hemostatic techniques used in endometrioma surgery on ovarian function By Demet Candaş Green

This publication reports on an ongoing clinical trial that aims to assess whether the hemostatic techniques (methods to stop bleeding) used in ovarian endometrioma surgery have damaging effects on ovarian function. The clinical trial stemmed from a multitude of inconclusive…

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Not a malignancy, it is "polypoid endometriosis"

Not a malignancy, it is By Irem Onur

Ghafoor S. et al., from Memorial Sloan Kettering Cancer Center, NY, USA, has recently reported a case of a 60-year-old postmenopausal woman with an incidental pelvic mass mimicking a pelvic malignancy on ultrasound. Their paper has been published in the…

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DNA repair defects and Endometriosis

DNA repair defects and Endometriosis By Dr. Youngran Park

Endometriosis is a hormone-dependent disorder and highly associated with inflammation. It is well suggested that endometriosis increases the risks of developing cancers such as ovarian, breast, endocrine, and colorectal cancers. Compared to cancer, there are many similarities in endometriosis. Well-known characteristics…

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What happens to women with endometriosis after menopause?

What happens to women with endometriosis after menopause? By Selma Oransay

Endometriosis affects women in their reproductive period of life, with expected regression of lesions in the postmenopausal period. Literature about postmenopausal endometriosis assessing the prevalence, pathogenesis, and treatment is limited. As 2-5 % of postmenopausal women are affected by this uncommon condition, developing stress…

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Disparities in Access to Healthcare in Women with Endometriosis

Disparities in Access to Healthcare in Women with Endometriosis By Özge Özkaya

There are significant differences in the use of medical services and prescriptions between women with endometriosis who have private healthcare and those who don’t. This is according to a study published in the American Journal of Obstetrics and Gynaecology.   This…

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A miniaturized version of endometrium: organoids for endometriosis research

A miniaturized version of endometrium: organoids for endometriosis research By Yu Yu

Organoids are a miniaturized version of a tissue that is produced in culture through three dimensions techniques in order to better mimic the tissues of origin. These cultures are supposed to better replicate the complexity of a biological organ/disease. Endometrial…

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The accuracy of "lower endoscopic ultrasound" for the preoperative diagnosis of rectosigmoid endometriosis

The accuracy of By Hale Goksever Celik

Endometriosis affects reproductive-aged women most frequently with a prevalence of 5% to 15%. If the endometriotic lesions involve the bowel especially sigmoid colon and rectum, this subtype of endometriosis is named as "bowel" or "rectosigmoid" endometriosis. Rectosigmoid endometriosis is encountered in…

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Plausible biomarkers for noninvasive endometriosis diagnosis

Plausible biomarkers for noninvasive endometriosis diagnosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent benign gynecological disease characterizing ectopic deposition of endometrial tissue outside of the uterine cavity. It affects about 10% of reproductive-aged women and causes enormous negative impacts on the quality of lives. However, we do not have…

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Nanotechnology as a tool for targeted therapy of endometriosis

Nanotechnology as a tool for targeted therapy of endometriosis By Murat Osman

Endometriosis is a process whereby endometrial cells persistently grow and invade extra-uterine tissue through a primarily estrogen-dependent manner. These ectopic endometrial cells proliferate in sometimes an uncontrolled manner, similar to cancer or inflammatory tissues. To proliferate, cells need cholesterol to…

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How to Classify Endometriosis for a better and effective evaluation

How to Classify Endometriosis for a better and effective evaluation By Selma Oransay

Endometriosis affects 10% of women in their reproductive period and causes infertility around 40% of women who have the disease. Peritoneal fluid may be one of the factors to facilitate the spread of endometriosis to ovaries, peritoneum and other deep…

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Mortality of 49956 midlife women with surgically verified endometriosis

Mortality of 49956 midlife women with surgically verified endometriosis By Irem Onur

Saavalainen L. et al., from Finland recently published a retrospective large cohort study in the journal Human Reproduction, where they retrospectively examined the data of surgically verified endometriosis patients to find out if all-cause and the cause-specific mortality rate is…

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Which Diagnosis Technique is Better?

Which Diagnosis Technique is Better? By Özge Özkaya

Transvaginal ultrasound provides a more accurate localization of vaginal and recto-vaginal endometriosis compared to magnetic resonance imaging (MRI) according to a study published in the International Journal of Gynecology & Obstetrics. However, MRI has better accuracy in detecting bladder endometriosis…

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Pregnancy with endometriosis

Pregnancy with endometriosis By Demet Candaş Green

Current literature suggests that complications of endometriosis during pregnancy are rare; however, a non-negligible increase in the likelihood of placenta accreta (placenta grows too deeply into the uterine wall), preterm birth, and cesarean delivery has been reported. With the increase…

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Prescription Opioid Use in Women With Endometriosis

Prescription Opioid Use in Women With Endometriosis By Deniz Kocas

In this study, researchers examined opioid use, opioid prescribing patterns, and timing of the first opioid prescription in endometriosis patients compared with matched women in the control group without endometriosis. A retrospective analysis of Optum Clinformatics Data Mart was conducted.…

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Early Developmental Gene May Play a Role in Endometriosis

Early Developmental Gene May Play a Role in Endometriosis By Özge Özkaya

An early developmental gene called twist may encourage the connective tissue cells of the lining of the uterus to change from being epithelial to being mesenchymal, so-called epithelial to mesenchymal transition (EMT).  Mesenchymal cells play important roles in biological processes…

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Infertility in women with endometriosis

Infertility in women with endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. The most common presenting complaints are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Despite extensive research, the etiopathogenic mechanism underlying the two has not been fully elucidated. Although human…

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The Effect of Imbalanced Progesterone Receptors-A/B on Gelatinase Expressions in Endometriosis

The Effect of Imbalanced Progesterone Receptors-A/B on Gelatinase Expressions in Endometriosis By Dr. Youngran Park

Endometriosis is a benign disease which affects approximately 10% of reproductive-aged women and is one of the most common reasons for infertility. Though the underlying mechanisms of disease progression have not been clearly understood, it develops as a consequence of…

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Fusion US/MR imaging in the evaluation of deep infiltrating endometriosis

Fusion US/MR imaging in the evaluation of deep infiltrating endometriosis By Timur Seckin

Scioscia M. et al., from Italy presented a case of a large deep infiltrating nodule of the uterosacral ligament and discussed the importance of a relatively new technique, fusion US/MR imaging in their article. The article containing a video of…

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Endometriosis that involves the nerves: how Radiologists can help

Endometriosis that involves the nerves: how Radiologists can help By Murat Osman

Endometriosis is a disease with variable clinical symptoms. While rare, nerve involvement by endometriosis may cause neurologic symptoms such as pelvic pain, muscle weakness, bowel and bladder incontinence, and paraplegia depending on the specific nerve involved. Thus, abdominal radiologists should…

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A position statement of diagnosing and treating endometriosis for gynecologists.

A position statement of diagnosing and treating endometriosis for gynecologists. By Selma Oransay

Endometriosis Treatment Italian Group recently declared 10 "valuable" conducts to evaluate endometriotic patients and published them in Hum. Reprod. Open. This society consists of 16 university departments and training center with expert clinicians on endometriosis from Italy. After arising the idea of…

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Botox as a promising treatment for chronic pelvic pain in endometriosis

Botox as a promising treatment for chronic pelvic pain in endometriosis By Irem Onur

Botulinum toxin (Botox) for treating chronic pelvic pain specifically addressing women with endometriosis has been studied for the first time by Tandon et al., from Bethesda, Maryland, USA. Their paper has recently been published in the journal Regional Anesthesia &…

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MRI or TVS for accurate diagnosis of rectosigmoid endometriosis?

MRI or TVS for accurate diagnosis of rectosigmoid endometriosis? By Demet Candaş Green

Rectosigmoid endometriosis (RE) is seen in about 90% of patients with bowel endometriosis. Rectosigmoid is the region between the rectum and the sigmoid colon, which is a region easily accessed and assessed by two most common noninvasive imaging modalities –…

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Health care resource utilization and cost in women with endometriosis

Health care resource utilization and cost in women with endometriosis By Hale Goksever Celik

Endometriosis is a chronic inflammatory disease affecting 6-10% of reproductive-aged women. The clinical picture of the disease range from asymptomatic findings to dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Endometriosis has also complex etiopathogenetic background. This broad clinical spectrum, the…

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Chronic Fatigue Syndrome and Endometriosis: Comorbid Conditions

Chronic Fatigue Syndrome and Endometriosis: Comorbid Conditions By Irem Onur

In the study of Dr. Boneva et al., from Atlanta, GA, the United States which has recently been published in the journal Frontiers in Pediatrics evaluated the impact of endometriosis on the health of women with chronic fatigue syndrome (CFS). The authors compared…

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A study about adnexial torsion doubts in patients with endometriosis.

A  study about adnexial torsion doubts in patients with endometriosis. By Selma Oransay

Endometrioma is the presence of endometriosis cysts in the ovary, and is one of the most common forms of endometriosis, with unknown pathophysiology. Adnexal torsion results in twisting ovarian tissues resulting in a decreased blood flow. The causes for adnexal torsion due…

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Patients with Pelvic Pain Most Likely to Benefit from Endometriosis Surgery

Patients with Pelvic Pain Most Likely to Benefit from Endometriosis Surgery By Özge Özkaya

Women who experience higher levels of pain are more likely to show improvement in their quality of life (QoL) following endometriosis surgery, according to a study published in The Journal of Minimally Invasive Gynecology. Chronic pelvic pain seems to be…

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Surgical treatment of deeply infiltrating endometriosis in tertiary treatment centers

Surgical treatment of deeply infiltrating endometriosis in tertiary treatment centers By Demet Candaş Green

In the present study, data from patients who were surgically treated for deep infiltrating endometriosis (DIE) in a tertiary referral unit, the Avicenna Centre for Endometriosis and Minimally Invasive Gynecology (ACEMIG, Tehran, Iran), were examined for rates of intraoperative and…

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The predictors for the coexistence of uterine leiomyomas and endometriosis

The predictors for the coexistence of uterine leiomyomas and endometriosis  By Hale Goksever Celik

Uterine leiomyomas are the most common gynecological benign tumors affecting 20-25% of reproductive-aged women. Abnormal bleeding, pelvic pain, pelvic pressure, and infertility are major symptoms of these tumors. Endometriosis is another gynecological disease encountered in 10-15% of reproductive-aged women. The…

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Control on endometriosis progression by a "tyrosine kinase inhibitor"

Control on endometriosis progression by a By Irem Onur

B cells, which are important players of the immune system, are increased in the blood and peritoneal cavity of endometriosis patients. Activation of B cells and the presence of anti-endometrial autoantibodies have been also been described in women with endometriosis,…

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Transvaginal Ultrasound and the Imaging of Endometriosis

Transvaginal Ultrasound and the Imaging of Endometriosis By Murat Osman

Ultrasonography (US) is an imaging tool that uses sound waves to produce a two-dimensional picture inside of the body. The ultrasonography has become especially useful in the assessment of gynecologic pathologies such as endometriosis. Depending on the severity of endometriosis,…

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Importance of monocytic myeloid derived supressor cells in endometriosis

Importance of monocytic myeloid derived supressor cells in endometriosis By Nasuhi Engin Aydin

Myeloid-derived suppressor cells MDSCs are immature myeloid cells that play a major role in immunosuppression in various disease processes.  Ya Sun and associates have investigated these cells in endometriosis utilizing various laboratory methods. published their results in the "American Journal of…

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"Endometriosis", "Fibromyalgia" and "Autoimmune diseases"

By Irem Onur

Greenbaum et al. from Israel, investigated the prevalence of and the association between endometriosis, fibromyalgia and autoimmune diseases in a large population database and described healthcare resource utilization in affected women. Their study has been published in the "American Journal…

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Seven Hormonal Biomarkers for Diagnosing Endometriosis

Seven Hormonal Biomarkers for Diagnosing Endometriosis By Dr. Youngran Park

Endometriosis is an inflammatory condition characterized by implantation and invasive growth of endometrial tissue outside the uterine cavity. Although it is benign, endometriosis has cancer-like features, a mutation profile similar to that of ovarian cancer, and increased ovarian cancer risk.…

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Baby Years and the Risk of Endometriosis

Baby Years and the Risk of Endometriosis By Özge Özkaya

Early-life factors such as whether a baby was breastfed, have had vaginal bleeding at birth, or whether or not their father was a smoker may be associated with her risk of developing endometriosis in later life.  This is according to…

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Analogous pathways of peritoneal tumor wound healing and endometriosis.

Analogous pathways of  peritoneal tumor wound healing and endometriosis. By Selma Oransay

Endometriosis, diagnosed around 10-15% of women population in their reproductive period, is a chronically progressive inflammatory disease to cause peritoneal lesions while spreading into the abdominal cavity. The pathophysiology of the adhesions between the peritoneum and pelvic organs can be…

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Endocrine-disrupting chemicals – yet another environmental factor associated with endometriosis?

Endocrine-disrupting chemicals – yet another environmental factor associated with endometriosis? By Demet Candaş Green

This study by Wen et al., published in Gynecological Endocrinology, analyzed evidence connecting endocrine-disrupting chemicals (EDCs) to the incidence of endometriosis in a collection of 30 previously published studies. Results show that exposure to many EDC's are linked to the…

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Urocortin: A biomarker deserving investigation for endometriosis patients

Urocortin: A biomarker deserving investigation for endometriosis patients By Irem Onur

Urocortin is a neuropeptide in the corticotropin-releasing hormone family and is expressed by eutopic and ectopic human endometria. Since it has paracrine and immunomodulatory effects, urocortin is thought to contribute to the pathogenesis of endometriosis. Its expression has been thoroughly…

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The coelomic metaplasia hypothesis of endometriosis in MRKH cases

The coelomic metaplasia hypothesis of endometriosis in MRKH cases By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity and its incidence is approximately 10% in the general female population. Although the pathophysiological mechanism is not clearly understood, the implantation theory by Sampson…

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ENDORECT scoring system to identify patients at risk for rectosigmoid endometriosis

ENDORECT scoring system to identify patients at risk for rectosigmoid endometriosis By Murat Osman

Patients who suffer from endometriosis may benefit from a preoperative score that predicts rectosigmoid involvement. A recent paper published by Huchon et al. at Poissy Saint-Germain en Laye, France, recruited 119 women who underwent laparoscopy for endometriosis between 2011 and…

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Endometriosis pathophysiology: research in genes updated

Endometriosis pathophysiology: research in genes updated By Nasuhi Engin Aydin

Endometriosis has a broad spectrum of environmental influences and genetic factors. I In this recently published review article in Experimental and Therapeutic Medicine, Vassilopoulou and associates present information about gene‑gene and gene‑environment interactions involved in endometriosis and discuss the effectiveness…

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Novel inhibitors of estrogen biosynthesis

Novel inhibitors of estrogen biosynthesis By Dr. Youngran Park

Endometriosis is a chronic benign disease which is estrogen-dependent. Estradiol creates a positive feedback loop with the synthesis of pro-inflammatory mediators, which sustains further disease establishment and causes the pain symptoms. However, hormone therapies do not cure definitively endometriosis, because…

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Searching new biomarkers for endometriosis

Searching new biomarkers for endometriosis By Selma Oransay

This recent article published in Advances in Clinical Chemistry, is an overall summary of characteristics, physiopathological theories, diagnostic approaches and variety of biomarkers to diagnose endometriosis and penned by Coutinho et al. from Universidade Federal de Juiz de Fora, Belo Horizonte,…

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The association of significant hemoperitoneum (blood in the abdominal cavity) and deep pelvic endometriosis

The association of significant hemoperitoneum (blood in the abdominal cavity) and deep pelvic endometriosis By Irem Onur

 Although there are several theories to explain the etiology of deep endometriosis, the cause is unknown and there are currently no effective strategies to prevent its development. Bean E. et al., from University College London Hospital, UK,  observed that some…

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The Wnt/b-catenin signaling in endometriosis

The Wnt/b-catenin signaling in endometriosis By Dr. Youngran Park

Endometriosis is a very common gynecological disorder, which affects approximately 10% of reproductive-aged women, and is one of the most common reasons for infertility. The normal endometrium undergoes cyclical remodeling under control of sex hormones secreted by ovaries- estrogen and…

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Non‑invasive biomarkers for endometriosis diagnosis

Non‑invasive biomarkers for endometriosis diagnosis By Hale Goksever Celik

Endometriosis is a disease of women in reproductive age and its incidence varies between 5-10%. Since the diagnosis is based on the histological confirmation, there is an average of 7 to 11 years of delays in the diagnosis. Promising non-invasive…

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The reason for lower BMI and less body fat in women with endometriosis.

The reason for lower BMI  and less body fat in women with endometriosis. By Selma Oransay

Zolbin et al. from the Department of Obstetrics and Gynecology of Yale School of Medicine, New Haven, USA, recently published the results of their prospective controlled research on adipocyte alterations in endometriosis, in the journal "Reproductive Biology and Endocrinology". Endometriosis can…

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Fibrogenesis in endometriosis: The role of neuropeptides

Fibrogenesis in endometriosis: The role of neuropeptides By Dr. Youngran Park

Endometriosis is a debilitating gynaecologic disease affecting 6–10% of women of reproductive age. Endometriotic lesions are known to be hyperinnervated due to neurogenesis resulting from neutrophins secreted by endometriotic lesions and possibly platelets. These neutrophins seem to preferentially favor the…

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New findings in adenomyosis (endometriosis interna) patients with potential theraupetic research implications

New findings in adenomyosis (endometriosis interna) patients with potential theraupetic research implications By Nasuhi Engin Aydin

Xue Shen and associates from Beijing, China have published their observations related to cannabinoid receptors, i.e., CB1 and CB2, in patients with adenomyosis, recently in the journal  "Biomed Research International".  Adenomyosis is an estrogen-dependent uterine disorder where a nonmalignant invasion…

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Pathophysiology of peritoneal endometriosis pain.

Pathophysiology of peritoneal endometriosis pain. By Serdar Balci

This article is an invited editorial by Ferrero S et.al. from IRCCS Ospedale Policlinico San Martino, Genoa, Italy, published in the Annals of Translational Medicine. The authors describe the pathophysiology and underlying mechanisms of pain in peritoneal endometriosis with reference to the…

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The genetic predisposition to endometriosis

The genetic predisposition to endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. Although endometrium is a non-malignant disease, its symptoms can range from mild to severe due to the inflammation that ectopic endometrial tissue forms around itself. The exact etiopathogenetic mechanism…

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A new hope for a "targeted" drug for endometriosis

A new hope for a By Selma Oransay

Lin et al. from National Cheng Kung University, Taiwan, recently published in"Theranostics" the article entitled "Targeting Anthrax Toxin Receptor 2 Ameliorates Endometriosis Progression”,  report that ANTRX2 may be a novel therapeutic target for endometriosis. Thinking that the adhesion should be the first and the…

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Anti-angiogenic treatment for endometriosis

Anti-angiogenic treatment for endometriosis By Dr. Youngran Park

Endometriosis is a benign, estrogen-dependent gynecological disorder. The wide variety of surgical and medical treatment has been applied for treating endometriosis, but a definitive therapy has not been achieved so far. Thus, new therapeutic strategies need to be developed. Among…

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Plasma Energy for Ovarian Endometriomas

Plasma Energy for Ovarian Endometriomas By Timur Seckin

There are many different approaches used in the management of ovarian endometriomas such as stripping cystectomy, ablation, including electrical/thermal and CO2 laser ablation, fenestration/aspiration, and combined techniques. Plasma energy is a new promising treatment option for ovarian endometrioma and may be…

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Proposed algorithm for a clinical diagnosis of endometriosis.

Proposed algorithm for a clinical diagnosis of endometriosis. By Selma Oransay

This recently published article in the American Journal of Obstetrics and Gynecology is about the challenge of diagnosing endometriosis, its impact on women's daily life and authored by Agarwal et al. from The University of California, San Diego, CA, USA. Authors called attention…

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Adenomyosis (endometriosis interna): an enigmatic disease that has to be discovered yet

Adenomyosis (endometriosis interna): an enigmatic disease that has to be discovered yet By Nasuhi Engin Aydin

Scientists, Drs. Vannuccini and Petraglia from Italy have published an open access comprehensive review of Adenomyosis in "F1000Research" in March 2019 issue. Adenomyosis is a uterine disorder in which endometrial glands and stroma are pathologically demonstrated within the myometrium, i.e.…

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Endometrial single cells to contribute preexisting endometriosis.

Endometrial single cells to contribute preexisting endometriosis. By Dr. Youngran Park

Endometriosis is an estrogen-dependent inflammatory disease. This disease affects approximately 10% of reproductive-aged women and 20% to 50% of infertile women. Multiple hypotheses have been proposed for the origin of endometriosis. Retrograde menstruation is believed to take part by the…

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Reducing the Risk of Recurrence After Endometriosis Surgery

Reducing the Risk of Recurrence After Endometriosis Surgery By Özge Özkaya

The use of compounds called NF-κB inhibitors and β-blockers before and after endometriosis surgery may reduce the risk of the disease recurring, according to a study conducted in a mouse model. According to the study published in the journal Reproductive…

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Antibiotic therapy for endometriosis

Antibiotic therapy for endometriosis By Yu Yu

Current treatments for endometriosis are surgery and hormone therapy; however, these approaches may have significant side effects and do not prevent a recurrence. Therefore, alternative treatment modalities for endometriosis is needed. Recently, the idea that endometriosis may be influenced by…

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The postoperative functional outcomes of deep infiltrating endometriosis

The postoperative functional outcomes of deep infiltrating endometriosis By Hale Goksever Celik

Rectosigmoid endometriosis is defined as the infiltration of the bowel wall with the endometrial-like glands and stroma, reaching at least the muscular layer. The most commonly involved sites are the rectum and sigmoid colon. For the management of deep infiltrating…

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A new trial to reduce the failure of IVF/ICS protocols in severe endometriosis

A new trial to reduce the failure of IVF/ICS protocols in severe endometriosis By Selma Oransay

Kong et al., from the first affiliated hospital of Zhengzhou University, China, recently published this single-blinded, a multicentered and randomized controlled study in the Journal of Reproductive Health, with the aim to find a safer and more effective ovulation induction regimen for patients with…

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Endometriosis and nuclear receptors

Endometriosis and nuclear receptors By Dr. Youngran Park

It is well recognized that endometriosis is a steroid-dependent disorder. In endometrial stromal cells, progesterone regulates retinoic acid production and action. Retinoids also act via a number of nuclear receptors (NRs) and are involved in normal endometrial function and endometriosis. Estrogen…

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The role of adhesion molecules, E-cadherin and hScrib, in endometriosis

The role of adhesion molecules, E-cadherin and hScrib, in endometriosis By Nasuhi Engin Aydin

Dr. Zhuo Ouyang and associates from the Capital Medical University, Beijing, China have recently published their research related to adhesion molecules in "Medicine (Baltimore)". Endometriosis is a “benign gynecological disease with some similarities to cancer”. Adhesion molecules E-cadherin and hScrib…

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Bladder Endometriosis

Bladder Endometriosis By Demet Candaş Green

Bladder endometriosis is rare – about 1-2% of women with endometriosis may have endometrial lesions in their urinary tract. Diagnosis of bladder endometriosis is difficult because of its nonspecific symptoms such as frequent urination, pelvic pain, and burning sensation when…

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The coexistence deep infiltrating endometriosis and fibromyalgia

The coexistence deep infiltrating endometriosis and fibromyalgia By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The main symptoms of endometriosis which are dysmenorrhea, dyspareunia, and chronic pelvic pain impair the quality of life of these women. This disease may…

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MRI-based "ENZIAN" scoring system and intra-operative endometriosis findings

MRI-based By Murat Osman

Endometriosis is a chronic inflammatory disease whereby endometrial-like glands grow and invade the extra-uterine structures. Endometriosis may affect various parts of the body, including the peritoneum, ovaries, or retroperitoneum. Recently, non-invasive methods for detecting these lesions have included trans-vaginal ultrasound…

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Epithelial Mutations in Endometriosis

Epithelial Mutations in Endometriosis By Dr. Youngran Park

A substantial body of epidemiologic evidence suggests a link between endometriosis and epithelial ovarian cancer, but a plausible underlying mechanism has remained elusive. Here, Dr. Bulun group from Northwestern University provide a focused review of the literature and discuss the…

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Antimullerian Hormone, endometrioma and ovarian reserve

Antimullerian Hormone, endometrioma and ovarian reserve By Selma Oransay

Younis et al. from Baruch-Padeh Medical Center, Poriya, Israel, designed a review study on ovarian reserve alterations before and after endometrioma surgery that recently documented in "Human Reproduction Update". The authors examined the electronic databases of articles published between January…

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A highly sensitive Immunohistochemical Marker for Stromal Cells in endometriosis

A highly sensitive Immunohistochemical Marker for Stromal Cells in endometriosis By Nasuhi Engin Aydin

Endometriosis is diagnosed histopathologically by the presence of endometrium-like tissues outside the uterus. Positive CD10 immunohistochemistry, highlighting stromal cells of the endometrium, is a useful adjunct for pathologists in the tissue diagnosis. However, CD10 expression is not specific to endometrial stromal…

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A guide on the Assessment of Pelvic Endometriosis Imaging

A guide on the Assessment of Pelvic Endometriosis Imaging By Murat Osman

Endometriosis is a disease whereby ectopic endometrial-like tissue invades and survives outside of the endometrial cavity. While biopsy-proven confirmation of endometriosis during laparoscopy has been considered the gold standard for diagnosis, non-invasive imaging modalities are increasingly being utilized for preoperative…

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Can early-life exposures affect endometriosis development later in life?

Can early-life exposures affect endometriosis development later in life? By Demet Candaş Green

Endometriosis is a complex disease with possible multifactor contributors. So far, inflammatory, immunogenic, genetic, and environmental factors have all been associated with endometriosis. In addition, it is possible that different types of endometriosis lesions – peritoneal, ovarian, and deep infiltrating…

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Choosing the Right Technique for Deep Colorectal Endometriosis

Choosing the Right Technique for Deep Colorectal Endometriosis By Dr. Youngran Park

Endometriosis is a benign gynecologic condition, histologically defined by the presence of ectopic endometrium outside the endometrial cavity. Three clinical presentations of endometriosis have been described and could coexist in the pelvis: peritoneal endometriosis, ovarian endometriosis, and deep infiltrating endometriosis.…

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Ovarian stimulation regimes: Concerns on progression or recurrence of endometriosis

 Ovarian stimulation regimes: Concerns on progression or recurrence of endometriosis By Selma Oransay

Somigliana et al., from the University of Milan, Italy, performed a literature review to predict the endometriosis-enhancing effect of ART regimes on infertile women and reported their results in Reproductive Biomedicine Online. Their points of interest were increasing dysmenorrhea, dyspareunia, non-menstrual pain and…

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Preoperative factors to predict unresponsiveness in women undergoing endometriosis surgery

Preoperative factors to predict unresponsiveness in women undergoing endometriosis surgery By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Despite extensive research, the optimal management of endometriosis still remains unclear. Several treatment options include analgesic medication, hormonal treatments, and surgical intervention. There is…

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Impact of Endometriosis-Related Adhesions on Quality of Life among Infertile Women

Impact of Endometriosis-Related Adhesions on Quality of Life among Infertile Women By Dr. Youngran Park

Endometriosis is considered the most common cause of pelvic adhesions in women. It is considered one of the main underlying causes of the development of adhesions. Adhesions are bands of connective tissue, which connect two different tissues that are normally…

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Menstrual blood-derived stem cells

Menstrual blood-derived stem cells By Selma Oransay

Chen et al.  from the Center of Diagnosis and Treatment of İnfectious Disease, Zhejiang University, China penned this recent review in the Journal of Stem Cell Research Therapy which is presenting the clinical potential of MenSCs (Menstrual blood-derived stem cells). …

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Endometriosis involving the superficial peritoneum in Adolescents: Surgical Management

Endometriosis involving the superficial peritoneum in Adolescents: Surgical Management By Murat Osman

Endometriosis is a chronic disease whereby endometrial glands and stroma grow and survive outside of the uterus. In some cases, endometriosis may become symptomatic and cause debilitating, chronic pelvic pain. Among pelvic organ and other surfaces that endometriosis can involve…

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Polymorphisms of STAT4 gene in the pathogenesis of endometriosis

Polymorphisms of STAT4 gene in the pathogenesis of endometriosis By Dr. Youngran Park

Endometriosis is one of the most common gynecological diseases in reproductive-age women characterized by the occurrence of endometrial tissue outside the uterine cavity. Researchers have put forward numerous hypotheses to explain ectopic endometrial tissue, and the bulk of the evidence…

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The appearance of postoperative endometriosis by imaging methods

The appearance of postoperative endometriosis by imaging methods By Hale Goksever Celik

Endometriosis is a chronic gynecological disease mostly encountered in reproductive-aged women. Endometriosis can occur in three different entities: peritoneal, ovarian and deep endometriosis. Golden standard diagnosis is made by histopathological examination of surgical material after laparoscopic surgery in women with…

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Endometriosis and infertility: current concepts

Endometriosis and infertility: current concepts By Nasuhi Engin Aydin

Hungarian and US scientists have published a comprehensive review on infertility related to endometriosis in Frontiers in Endocrinology, November 2018 issue.  Endometriosis is a common entity in women of reproductive age which often leads to infertility. Compiled research data reveal…

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Gal-3 can be a pharmacological target in endometriosis treatment

Gal-3 can be a pharmacological target in endometriosis treatment By Demet Candaş Green

Galectins are known to play a significant role in angiogenesis, which is a key event contributing to the development of many disease conditions, one of which is endometriosis. Past studies, upon examining several human endometriotic lesions, showed that Galectin-3 (Gal-3)…

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Estrogen Receptor Signaling and Endometriosis-Associated Ovarian Cancer

Estrogen Receptor Signaling and Endometriosis-Associated Ovarian Cancer By Selma Oransay

Andersen et al. published a prospective cohort study in the Journal of Hormones and Cancer to enlighten the estrogen signaling pathway during the transition from endometriosis to endometriosis-associated ovarian cancer. Given the shared pathway of endometriosis and ovarian cancer as…

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Immunologic Disorder in the Progression of Endometriosis

Immunologic Disorder in the Progression of Endometriosis By Dr. Youngran Park

Endometriosis becomes increasingly a health-social problem. However, definite diagnostic biomarkers and more effective treatments for endometriosis are still missing to this day.  Many researchers focus on the peritoneal microenvironment of patients with endometriosis, especially the immunological microenvironment. Recently, Jørgensen et…

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The miscarriage rate in women with endometriosis undergoing IVF fresh cycles

The miscarriage rate in women with endometriosis undergoing IVF fresh cycles By Hale Goksever Celik

Endometriosis is a chronic estrogen-dependent disease diagnosed in 25-40% of women with infertility. There are several mechanisms explaining the negative impacts of endometriosis on fertility through the entire reproductive process such as sperm-oocyte interaction, ovarian reserve, and implantation. Endometriosis is…

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A link between endometrioid ovarian carcinoma and endometriosis.

A link between endometrioid ovarian carcinoma and endometriosis. By Selma Oransay

Ciavattini et al.from Polytechnic University Ancona, Italy create a pilot study which recently published in Oncology Letters to clarify the link between endometriosis and endometrioid ovarian cancer. The unfolded protein response (UPR) activity as a promoter of neoplastic progression of malignancies is…

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Long non‐coding RNA, Epithelial mesenchymal transition, and Endometriosis

Long non‐coding RNA, Epithelial mesenchymal transition, and Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen‐dependent inflammatory gynecologic disease and requires attention. However, an in‐depth understanding of the latent pathogenesis of endometriosis development and its new innovative therapeutics are urgently needed. Epithelial‐mesenchymal transition (EMT) refers to the special biological process of epithelial…

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Which comes first in endometriosis management: In vitro fertilization or surgery?

Which comes first in endometriosis management: In vitro fertilization or surgery? By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence is found to be 7%–10%, but among infertile women, it increases up to 50%. Early diagnosis and personalized management are important to…

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Self-management of endometriosis symptoms: from Australia

Self-management of endometriosis symptoms: from Australia By Demet Candaş Green

Effective self-management techniques and lifestyle changes may play an important role in the management of endometriosis symptoms by many women. Due to various reasons such as limited effectiveness of some medications, potential side effects, availability of medical resources, self-desire to…

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Priorities and Unmet Needs of Endometriosis Management

Priorities and Unmet Needs of Endometriosis Management By Murat Osman

Endometriosis is a systemic, chronic disease that is a significant contributor to morbidity in young women. Although endometriosis has gained increasing attention in the medical field, scientific progress for an effective and definitive treatment modality is progressing slowly. The Society…

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Endometrioma, Fertility, and Assisted Reproduction

Endometrioma, Fertility, and Assisted Reproduction By Dr. Youngran Park

Endometriosis can negatively impact a woman’s health and quality of life. Surgery has been considered the primary treatment to overcome infertility in cases of ovarian endometrioma. Patients struggling with endometriosis often pursue assisted reproductive technologies (ART) due to fertility issues.…

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Building an ultrasonographic database for superficial endometriosis.

Building an ultrasonographic database for superficial endometriosis. By Selma Oransay

Chowdary et al. from University of Auckland, Australia, recently published a retrospective, small group study in Australian New Zeland Journal of Obstetrics and Gynecology, to demonstrate ultrasonographic findings of mild endometriosis patients with pelvic pain are associated with their laparoscopic diagnosis.…

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PAX8 immunohistochemistry in the diagnosis of Extragenital Endometriosis

PAX8 immunohistochemistry in the diagnosis of Extragenital Endometriosis By Serdar Balci

This study is performed by Arakawa T et al., from the University of Tokyo, Tokyo, Japan, and the results are published in Reproductive Sciences. Endometriosis is seen in many organs including peritoneum, ovaries, bowel, bladder, and even lung. Histopathologic diagnosis may…

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The association between the development of endometriosis and dietary habits

The association between the development of endometriosis and dietary habits By Hale Goksever Celik

Endometriosis is a chronic disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence is found to be approximately 10% in the general population. Endometriosis is associated with infertility, pelvic pain, and increased…

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Bowel endometriosis: What you need to know

Bowel endometriosis: What you need to know By Demet Candaş Green

When the endometrial tissue infiltrates the intestinal walls and reaches inside the intestines, this condition is called "bowel endometriosis". It is estimated that between 3.8% and 37% of women with endometriosis are affected by bowel endometriosis. The endometriosis lesions infiltrating…

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Signs and Symptoms on Transvaginal Ultrasound associated with the presence of endometriosis.

Signs and Symptoms on Transvaginal Ultrasound associated with the presence of endometriosis. By Murat Osman

Endometriosis is a disease whereby ectopic endometrial cells are present outside of the uterus. Transvaginal ultrasound (TVUS) is a highly specific test for endometriomas and deep endometriosis to assess the involvement of endometriosis in the posterior anatomic compartments. While the…

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Exosome: a new avenue for endometriosis research

Exosome: a new avenue for endometriosis research By Dr. Youngran Park

Endometriosis affects 10% of reproductive-aged women. The pathophysiology of this disease remains mysterious, with a lack of effective biomarkers necessitating surgical intervention for diagnosis. This creates an urgent need for accurate noninvasive diagnostic tests and the identification of effective therapeutic…

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Additional research in understanding the causative link between Notch signaling and endometriosis

Additional research in understanding the causative link between Notch signaling and endometriosis By Nasuhi Engin Aydin

Dustin M. Brown and associates from the University of Arkansas for Medical Sciences published their unique complex molecular research in the Journal of the Endocrine Society. This study group previously showed that decreased expression of the progesterone receptor (PGR) resulted from…

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Can we prevent the progression of endometriosis?

Can we prevent the progression of endometriosis? By Selma Oransay

Torres-Reveron et al. from the University of Texas, USA, planned this prospective laboratory research on female rats to assay the reduce on the progression of endometriosis and recently published the results in PloS One. At first,  endometriosis was induced in female rats…

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Endometriosis and female pelvic pain in all aspects

Endometriosis and female pelvic pain in all aspects By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence of the disease ranges between 6-10% in reproductive-aged women. However, endometriosis is more frequently encountered in women with chronic pelvic pain and…

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The relationship between periodontal disease and endometriosis

The relationship between periodontal disease and endometriosis By Irem Onur

Thomas et al. have recently studied the association between endometriosis and periodontal disease which may share a common pathogenesis, and have published it in the Journal of Human Reproductive Sciences. The authors screened a total of50 women; 25 with and 25…

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Clonal Proliferation and Cancer Associated Mutations in normal uterine endometrium and endometriosis

Clonal Proliferation and Cancer Associated Mutations in normal uterine endometrium and endometriosis By Serdar Balci

Suda et. al., from Niigata University, Japan, has published the article entitled "Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium" in Cell Reports. There are many theories for endometriosis development (retrograde menstruation, coelomic metaplasia, Müllerian remnants),…

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Vaginal Sexual Intercourse during Menstruation

Vaginal Sexual Intercourse during Menstruation By Irem Onur

Mazokopakis and Samonis from Greece examined and discussed the vaginal sexual intercourse during menstruation from a biblical as well as a modern medical point of view in their paper published in MAEDICA – a Journal of Clinical Medicine in September 2018.…

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Somatic mutations in iatrogenic endometriosis.

Somatic mutations in iatrogenic endometriosis. By Selma Oransay

Lac and al., from the Department of Molecular Oncology in BC Cancer Research Center, Vancouver, Canada, planned a retrospective and multinational research to investigate the prevalence of somatic cancer-driver mutations in incisional endometriosis and recently published in the "Journal of Human Reproduction". Their…

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Mistletoe as a Potential Candidate for Endometriosis Treatment

Mistletoe as a Potential Candidate for Endometriosis Treatment By Dr. Youngran Park

Endometriosis, one of the common benign gynecologic disorders, is defined as the ectopic presence of endometrial cells outside of the uterine cavity. Although the underlying mechanisms are not fully understood, the most accepted hypothesis is that endometrial cells pass through…

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Surgical techniques for rectosigmoid endometriosis, and functional outcomes

Surgical techniques for rectosigmoid endometriosis, and functional outcomes By Hale Goksever Celik

Rectosigmoid endometriosis is defined as the infiltration of bowel wall with the endometrial-like glands and stroma, reaching at least the muscular layer. Rectosigmoid endometriosis is encountered in approximately 8-12% of patients with a diagnosis of endometriosis. The most commonly involved…

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A new theory in the pathogenesis of endometriosis

A new theory in the pathogenesis of endometriosis By Serdar Balci

Koninckx et. al., from various countries, have conducted this review, which will be published in Fertility and Sterility. Endometriosis is known for a century. The disease has a variable course in a patient, which may include pain, infections, and infertility.…

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Development of Less Invasive Diagnostic Tests for Endometriosis Through Proteomics

Development of Less Invasive Diagnostic Tests for Endometriosis Through Proteomics By Murat Osman

Proteomics is a field which utilizes various methods to carry out large-scale studies of proteins. Due to the inherent nature of the field, proteomics focuses on the identification, localization, and functional analysis of the protein make-up of a given type…

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New scientific evidence supporting robotic surgical approach to ureteric endometriosis

New scientific evidence supporting robotic surgical approach to ureteric endometriosis By Nasuhi Engin Aydin

Surgical treatment of ureteral endometriosis aims to relieve urinary obstruction besides preserving renal functions. In accomplishing these, the best method of surgical approach is still unclear. Andrea Giannini and her colleagues from the University of Pisa, Italy conducted a retrospective…

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Conservative Surgery May Be Sufficient to Halt the Development of Deep Endometriosis

Conservative Surgery May Be Sufficient to Halt the Development of Deep Endometriosis By Özge Özkaya

Deep endometriosis develops as a result of collective cell migration and nerve recruitment from surrounding organs, suggests a study published in the scientific journal Fertility and Sterility.   Collective cell migration is the biological process whereby a group of cells moves…

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The association of endometriosis and peritoneal malignant mesothelioma

The association of endometriosis and peritoneal malignant mesothelioma By Irem Onur

Endometriosis is well known to cause chronic inflammation of the serosa and incite mesothelial hyperplasia. Although multilocular peritoneal inclusion cysts and well-differentiated papillary mesothelioma were reported to be associated with endometriosis, the association of malignant mesothelioma has not been reported…

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Is the mystery for progression of endometriosis hiding out in abnormally located endometrial cells?

Is the mystery for  progression of endometriosis hiding out in abnormally located endometrial cells? By Selma Oransay

This prospective study was conducted by Hapangama et al. in Research İnstute of the University of Liverpool, UK, and the results have recently published in the Journal of Human Reproduction. The authors hypothesized that abnormally located endometrial basalis-like (SSEA1/nSOX9+)cells could be contributing to…

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The role of circulating microRNA's in Endometriosis

The role of circulating microRNA's in Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. This disease affects approximately 10% of reproductive-aged women and 20% to 50% of infertile women. Steroidogenic factor 1 (SF-1) is an essential transcriptional regulator coordinately regulating multiple genes involved in estrogen biosynthesis. SF-1 is known…

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Endometriosis-associated pain control by contraceptive implant or intrauterine system

Endometriosis-associated pain control by contraceptive implant or intrauterine system By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The most common symptoms are dysmenorrhea, dyspareunia, and chronic pelvic pain, all of which affect the quality of women’s lives. Several studies investigating the…

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Factors related to delay in endometriosis diagnosis

Factors related to delay in endometriosis diagnosis By Nasuhi Engin Aydin

Dr. Moniek van der Zanden, a gynecologist from Netherlands has recently made a nationwide survey on the impact of key recommendations of the European Society of Human Reproduction and Embryology (ESHRE) guidelines on endometriosis and aimed to assess factors influencing diagnostic delay of…

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Does the presence of endometriosis increase the risk of gynecologic malignancies?

Does the presence of endometriosis increase the risk of gynecologic malignancies? By Serdar Balci

Endometriosis shares common risk factors with endometrial carcinoma and ovarian carcinomas such as obesity, type 2 diabetes, hyperestrogenism, and reproductive characteristics. Endometriosis is also known to be a risk factor for gynecologic malignant tumors. In this study, Li et.al. have…

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Extragenital endometriosis and ultrasound

Extragenital endometriosis and ultrasound By Irem Onur

Contrast-enhanced ultrasound (CEUS) is a non-invasive imaging method with no exposure to radiation. There are a few reports on the use of CEUS in the assessment of endometriosis in the literature. Dong et al. reported 3 histopathologically proven cases of…

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Lipophilic Statins inhibit growth and invasiveness of human endometrial cells

Lipophilic Statins inhibit growth and invasiveness of human endometrial cells By Murat Osman

Endometriosis is a disease process whereby cells of the endometrium grow and invade structures outside of the uterus. Through recent research, it has been seen that endometriotic foci in women with endometriosis exhibit an altered phenotype that contributes to its…

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Can we Inhibit the Survival of Endometriosis?

Can we Inhibit the Survival of Endometriosis? By Dr. Youngran Park

Endometriosis is an estrogen-dependent gynecological inflammatory disease. The current anti-estrogen therapies can be prescribed only for a short time due to the undesirable side effects on menstruation, pregnancy, bone health, and recurrence. Therefore, the development of specific therapy which targets…

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Pelvic pain, congenital genital tract anomalies and endometriosis

Pelvic pain, congenital genital tract anomalies and endometriosis By Hale Goksever Celik

Any failure during development and differentiation of female genital tract results in congenital tract anomalies. The origin of the hymen is the union of the caudal portion of the paramesonephric ducts and the urogenital sinus. It functions as a mechanical…

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Further Results From the FEELING Study Published

Further Results From the FEELING Study Published By Özge Özkaya

Some women are more likely to develop deep infiltrating endometriosis according to the further analysis of the results of the FEELING study. These are women who: are married, are older,  have siblings,  have had a prior pregnancy,  or for whom…

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What clinicians know about adenomyosis? Any association with severe endometriosis?

What clinicians know about adenomyosis? Any association with severe endometriosis? By Selma Oransay

Dior et al. from the Royal Women's Hospital in Parkville, Australia, designed a prospective study to assess the association between severity of endometriosis and sonographic evidence of adenomyosis (SEOA) in their recently published article appearing in The Journal of Minimally…

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Immune dysregulation in endometriosis

Immune dysregulation in endometriosis By Yu Yu

The connection between endometriosis and the immune system has long been proposed. However, to date, there is no real consensus on whether immune adaptations actually facilitate endometriotric lesion progression or they are a consequence of endometriosis re-occurrence. Thus, this article…

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Targeted therapy biomarkers in endometriosis associated ovarian carcinomas

Targeted therapy biomarkers in endometriosis associated ovarian carcinomas By Serdar Balci

Endometriosis in ovaries is a known precursor of endometrioid and clear cell carcinomas. They may be resistant to classical therapies. Researchers search for alternative and targeted therapy options. This study, from the University of Campinas, Campinas, São Paulo, Brazil, will be…

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A Brief Review of Endometriosis

A Brief Review of Endometriosis By Timur Seckin

Endometriosis is a common disease among women of reproductive age. It is more frequently seen among women without prior pregnancies, women with a family history of endometriosis, and women with abnormal menstrual periods. Peiris et al., researchers from the United…

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Endometriosis: A review on anatomic principles and the management

Endometriosis: A review on anatomic principles and the management By Irem Onur

In the study of Alimi et al. which has been published in the journal Cureus, various aspects of endometriosis such as the pathophysiology, the anatomy, the pain mechanism, the perineural spread theory, clinical manifestations, diagnosis, and imaging, infertility, unusual cases,…

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Laparoscopic mesenteric vascular and nerve sparing surgery as a tool for DIE resection

Laparoscopic mesenteric vascular and nerve sparing surgery as a tool for DIE resection By Murat Osman

Endometriosis can be characterized by a wide range of clinical aggressiveness based upon the location, character, and growth of ectopic endometrial implants. As one of the most aggressive forms of endometriosis, deep infiltrating endometriosis (DIE) is known to involve the…

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Are women with histologically confirmed endometriosis satisfied with their medical support?

Are women with histologically confirmed endometriosis satisfied with their medical support? By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The most common symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, dyschesia, dysuria, musculoskeletal pain, fatigue and infertility, all of which affect the quality of…

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Anti-proliferative and anti-inflammatory effects of "Quercetin" on endometriosis

 Anti-proliferative and anti-inflammatory effects of By Dr. Youngran Park

Quercetin is a major flavonol that is mainly derived from capers and involves a daily consumption of approximately 25–50 mg through various vegetables. In recent studies, Quercetin is reported as a functional compound in obesity, diabetes and cardiovascular diseases. This compound…

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The use of Elagolix in Women with Liver and Kidney Impairments

The use of Elagolix in Women with Liver and Kidney Impairments By Özge Özkaya

Elagolix may be used in women with moderate liver impairment, when necessary, for up to six months at a dose of 150 mg a day, according to a study published in the scientific journal Clinical Pharmacology in Drug Development. The…

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Progesterone Receptor Status in Endometriosis

Progesterone Receptor Status in Endometriosis By Serdar Balci

Some patients do not respond to progesterone hormone therapy. In this study recently published in the Journal of Clinical Endocrinology and Metabolism, the authors led by Hugh S. Taylor from the Department of Obstetrics, Gynecology and Reproductive Sciences from Yale…

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Programmed-cell death pathway and immune dysfunction in endometriosis

Programmed-cell death pathway and immune dysfunction in endometriosis By Irem Onur

Endometriosis is an estrogen-dependent, immune-associated disease. Women with endometriosis have different proportions of the activated forms of immunocompetent cells, such as T cells and macrophages compared to those from women without. Immune cell dysfunction in the uterine and abdominal cavity…

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Drugs targeting estrogen biosynthesis opening up new approaches to the treatment of endometriosis.

Drugs targeting estrogen biosynthesis opening up new approaches to the treatment of endometriosis. By Selma Oransay

Gibson et al., from the Univerity of Edinburgh, UK, take over a new interest about endometriosis occurrence and progress by endometrial tissue intracrinology in their recently online published article in International Journal of Molecular Sciences. The authors summarize the last…

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How to predict natural conception in women underwent endometriosis surgery?

How to predict natural conception in women underwent endometriosis surgery? By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The most common symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. The prevalence of endometriosis increases in the infertile population. Thus, the important…

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Preoperative Staging of Endometriosis: The Value of MRI After Dynamic Transvaginal Ultrasound

Preoperative Staging of Endometriosis: The Value of MRI After Dynamic Transvaginal Ultrasound By Irem Onur

Since endometriosis is a chronic and progressive disease, early diagnosis and proper staging are important for the patient and for the clinician to discuss and plan the required surgical procedures for treatment. Common diagnostic tools for pre-operative staging of deep…

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An overlooked symptom of endometriosis: Fatigue

An overlooked symptom of endometriosis: Fatigue By Timur Seckin

A majority of endometriosis patients experience fatigue. This is according to a multicenter study conducted by a group of researchers from Switzerland, Germany, and Austria. Fatigue, and feeling spoonie, may be a symptom of endometriosis affecting the daily activities and…

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The pain and its severity in deeply infiltrating endometriosis patients

The pain and its severity in deeply infiltrating endometriosis patients By Selma Oransay

Liang et al. from the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Sun Yat-sen University, China, recently published an interesting paper in the Journal of Pain Research, a prospective study to reveal the relationship between neurogenesis and other potential…

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Any adjustable risk factor for Endometriosis?

Any adjustable risk factor for Endometriosis? By Irem Onur

Endometriosis is believed to be estrogen and progesterone-dependent. Lifestyle factors such as alcohol/caffeine intake, smoking, and physical activity influence estrogen levels in the body and, therefore, may impact the development of endometriosis. In the study of Hemmert et al. which…

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Is Physical Exercise Effective in Endometriosis?

Is Physical Exercise Effective in Endometriosis? By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial tissue outside the uterine cavity. Dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility are mostly encountered symptoms of endometriosis. Although there are several theories explaining the pathogenesis of endometriosis, the exact pathogenesis still has…

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Does ovarian endometrioma damage the ovarian reserve?

Does ovarian endometrioma damage the ovarian reserve? By Dr. Youngran Park

Ovarian endometriomas are commonly present in 17% to 44% of women with endometriosis and are often associated with infertility and pelvic pain. There are several treatment options including surgical treatment. Cyst excision is associated with better results in terms of…

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Four cases of endometrioid borderline ovarian tumour: case reports and literature review

Four cases of endometrioid borderline ovarian tumour: case reports and literature review By Nasuhi Engin Aydin

Physicians from Kyoto University Graduate School of Medicine, Kyoto, Japan, report four cases of ovarian EBTs and a review literature in a recently published manuscript at British Medical Journal, case reports. Endometrioid borderline tumors (EBTs) of the ovary are uncommon…

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The diagnosis and management of endometriosis in Korea

The diagnosis and management of endometriosis in Korea By Selma Oransay

The Korean Society of Endometriosis has scrutinized the present published literature of endometriosis in the domestic and international platform to provide new guidelines and the clinical management of the disease. The study was recently published in the journal "Obstetrics and Gynecology…

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A novel neurotransmitter, Ninj1, has been found to be expressed in endometriosis

A novel neurotransmitter, Ninj1, has been found to be expressed in endometriosis By Irem Onur

Chronic inflammation is involved in the pathogenesis of endometriosis and adenomyosis, and inflammatory cytokines such as IL-1b are highly expressed in them. Inflammation and subsequent hyperinnervation are involved in the pathophysiology of pain generation. High levels of expression of various…

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Can MRI be used to detect anterior pelvic endometriotic lesions?

Can MRI be used to detect anterior pelvic endometriotic lesions? By Hale Goksever Celik

Deep infiltrating endometriosis is the most severe manifestation of endometriosis. It is defined as the infiltration of ectopic endometrial tissue under the peritoneum, pelvic structures, and the organ walls such as the uterosacral ligaments, colon, vagina, bladder, ureter, rectovaginal septum,…

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Feasibility of MRI-Transvaginal Ultrasound Imaging for Deeply Infiltrating Endometriosis

Feasibility of MRI-Transvaginal Ultrasound Imaging for Deeply Infiltrating Endometriosis By Murat Osman

Endometriosis is a disease whereby endometrial tissue is present outside of endometrium. A specific form of endometriosis, Deeply Infiltrating Endometriosis (DIE), is characterized by endometriotic glands that invade through the endometrium and other structures in the pelvis and is associated…

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Does deep infiltrating endometriosis affect sexual activity?

Does deep infiltrating endometriosis affect sexual activity? By Dr. Youngran Park

Endometriosis is one of the most common gynecological diseases in women of reproductive age, and pelvic pain and infertility are the most frequent complications. There are three different type of endometriosis lesions; superficial lesions, deep lesions, and ovarian cysts. In…

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Autophagy, proteolysis and Endometriosis

Autophagy, proteolysis and Endometriosis By Kasthuri Nair

Sui et al., a group of researchers from the Qiqihar Medical University and Qilu Hospital of Shandong University, recently published in Experimental and Therapeutic Medicine. The piece titled “Expression and significance of autophagy genes LC3, Beclin1 and MMP-2 in endometriosis”…

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Best endometriosis articles of the past year.

Best endometriosis articles of the past year.  By Selma Oransay

Dr.Stowall, from the Department of Obstetrics and Gynecology of Methodist Hospital, Dallas, Texas, USA penned this letter and recently published it in the Journal of Obstetrics and Gynecology to show his remarks of importance on four best publications of the…

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Three dimensional sono-vaginography to diagnose rectovaginal endometriosis

Three dimensional sono-vaginography to diagnose rectovaginal endometriosis By Hale Goksever Celik

Deep infiltrating endometriosis is defined as the localization of ectopic endometrial tissue penetrating more than 5 mm into the affected pelvic organs. Rectovaginal endometriosis is the most severe form of deep infiltrating endometriosis in which ectopic endometrial tissue infiltrating rectum…

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Programmed cell death 4 suppresses endometriosis by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway

Programmed cell death 4 suppresses endometriosis by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway By Dr. Youngran Park

Endometriosis is a kind of benign disease but shares many similar features with cancers, such as abnormal cell migration, invasion, and unrestrained growth. It has been known that some genes are expressed differentially in eutopic endometrium of EM patients compared…

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Anatomic distribution of endometriosis

Anatomic distribution of endometriosis By Irem Onur

In the study of Audebert et al. which has been published in the journal European Journal of Obstetrics and Gynecology, the anatomic distribution of endometriosis, the rate of deep infiltrating endometriosis during the various study periods, laterality of endometriosis, pelvic…

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How Ovarian Endometriomas and DIE affect ART outcomes

How Ovarian Endometriomas and DIE affect ART outcomes By Murat Osman

Previous studies have evaluated the impact of an ovarian endometrioma on ovarian reserve and its impact on the success of assisted reproductive technology (ART) outcomes have controversial results.  ART is a method by which a woman’s own hormones are used…

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Suffering in Silence

Suffering in Silence By Deniz Kocas

Although quantitative and qualitative studies have established that endometriosis has a negative impact on multiple domains of quality of life, the majority of qualitative studies to date have used focus groups and interviews. These data collection methods may limit disclosure…

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Maternal and fetal outcomes in women with endometriosis : A review and meta-analysis

Maternal and fetal outcomes in women with endometriosis : A review and meta-analysis By Selma Oransay

Lalani et al from Dept. of Obstet. and Gynecol. , University of Ottowa, Canada, recently published this systemic review and meta-analysis of observational studies in the Journal of Human Reproduction, aimed to present the difference in the maternal and fetal…

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Could Endometriosis-Related Infertility Be Genetic?

Could Endometriosis-Related Infertility Be Genetic? By Özge Özkaya

Researchers identified genetic polymorphisms or individual differences in two genes called AMA5 and KAZN among women with endometriosis who were infertile and control women who were fertile. The identification of these polymorphisms could help scientists better understand why some women…

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Non-assisted reproductive technology treatment: Is it effective in infertile patients with advanced endometriosis?

Non-assisted reproductive technology treatment: Is it effective in infertile patients with advanced endometriosis? By Hale Goksever Celik

The marriage and childbearing ages delay due to the life-style changes in developed countries. As a result, advanced age becomes a major concern in infertility treatments which consist of non-ART and ART modalities. Non-ART treatments include mild ovarian stimulation together…

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IL-37 regulates ectopic endometrial stromal cells to prevent endometriosis

IL-37 regulates ectopic endometrial stromal cells to prevent endometriosis By Dr. Youngran Park

Endometriosis has been identified as a chronic inflammatory disease. It has been shown that in the plasma and peritoneal fluid, women with endometriosis exhibit aberrant numbers of immune cells and concentrations of cytokines and chemokines that promote a chronic inflammatory…

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PROPOFOL: a new combat for endometriosis?

PROPOFOL: a new combat for endometriosis? By Selma Oransay

Feng et al, from the Department of  Gynecology Weifang Medical University Hospital, Shandong, China, recently published their prospective experimental research in the journal Experimental and Therapeutic Medicine. Propofol, a rapid and short-term anesthetic substance, recently has been shown to prevent cancer through inhibiting…

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Parametrial endometriosis: A harder form of endometriosis

Parametrial endometriosis: A harder form of endometriosis By Hale Goksever Celik

Deep infiltrating endometriosis is the most severe manifestation of endometriosis, affecting 20% of all patients with endometriosis. It is defined as the infiltration of ectopic endometrial tissue under the peritoneum, pelvic structures, and the organ walls such as the uterosacral…

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Quality of life for women with endometriosis

Quality of life for women with endometriosis By Irem Onur

Endometriosis symptoms may cause difficulties in daily activities and social life, altering general health and personal relationships and severely decrease the quality of life. Yoldemir T. evaluates the factors affecting the quality of life in endometriosis patients and the management strategies in…

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Vitamin D and Endometriosis

Vitamin D and Endometriosis By Nasuhi Engin Aydin

Scientists from Milan, Italy reviewed the effects of vitamin D on the reproductive health, and in particular "endometriosis" in their article which appeared in International Journal of Molecular Sciences. Vitamin D (VD), is a steroid hormone that is activated in…

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Endometriosis involvement of the pouch of Douglas: TVUS vs pelvic exam

Endometriosis involvement of the pouch of Douglas: TVUS vs pelvic exam By Murat Osman

Deep infiltrating endometriosis (DIE) can lead to a partial or complete obliteration of the pouch of Douglas (POD). POD involvement has been associated with dyschezia, deep dyspareunia, and increased infertility rates. Assessing the extent of endometriosis involvement of the cul-de-sac allows…

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Will I Have Complications After Endometriosis Surgery?

Will I Have Complications After Endometriosis Surgery? By Özge Özkaya

The rate of complications after surgery to treat deep infiltrating endometriosis is low, confirmed a study by researchers in Germany. It is important to know whether major or minor complications following surgery are likely to develop and what the outcome…

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Inhibition of PI3K/AKT/mTOR pathway for the treatment of endometriosis.

Inhibition of PI3K/AKT/mTOR pathway for the treatment of endometriosis. By Dr. Youngran Park

Dr. Matsuzaki et al. (2018) published a paper entitled ‘In vitro and in vivo effects of MK2206 and chloroquine combination therapy on endometriosis’ showing that the efficacy of MK2206, an Akt inhibitor, in combination with chloroquine for inducing autophagy in…

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Laparoscopic surgery of endometriosis through three compartments

Laparoscopic surgery of endometriosis through three compartments By Selma Oransay

This case study which is published in the J. of Minimally İnvasive Gynecology is the video demonstration of Collin et al who performed the laparoscopic operation of their patient in Gynecologic Surgery Department of Strasburg Hospital University, France. 37 years old…

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How to preserve fertility in women with “ovarian endometriosis”?

How to preserve fertility in women with “ovarian endometriosis”? By Hale Goksever Celik

Although there are many treatment modalities in endometriosis, optimal treatment has not been developed yet. The aim of the treatment is to reduce pain, to preserve and improve fertility and to delay recurrence. Ovarian ischemic and perfusion damage during endometriosis…

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Multimodality imaging and clinicopathologic assessment of abdominal wall endometriosis

Multimodality imaging and clinicopathologic assessment of abdominal wall endometriosis By Irem Onur

Abdominal wall endometriosis is a rare clinical entity frequently diagnosed with a significant delay and easily misinterpreted despite multimodality imaging. In the study of Jaramillo-Cardoso et al. which has recently been published in the journal Abdominal Radiology, the clinical, multimodality…

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MTA1 as a predictor for the progression of endometriosis.

MTA1 as a predictor for the progression of endometriosis. By Selma Oransay

Jing Zhang et al. from the Department of Obstetrics and Gynecology, Affiliated Haikou Hospital, Xiangya Medical College of Central South University, Hainan, China, published their article in the open access medical journal "Medicine". Their aim was to evaluate the relationship between…

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A rare location of endometriosis: Perineum

A rare location of endometriosis: Perineum By Timur Seckin

A rare case of perineal endometriosis is reported by Dr. Ravikant, from India, and has been recently published in the "Journal of Medical Ultrasound".  The patient, a 28-year-old woman with one living child, presented with a 6-month history of a…

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Shedding light on the fertility preservation debate in women with endometriosis: a swot analysis.

Shedding light on the fertility preservation debate in women with endometriosis: a swot analysis. By Deniz Kocas

There is little known about fertility preservation in women with endometriosis. Researchers from France and Switzerland conducted a SWOT (strengths, weaknesses, opportunities, and threats) analysis to better understand this topic. Applied to clinical problems, SWOT gives a thorough analysis of…

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Fighting with endometriosis

Fighting with endometriosis By Irem Onur

Maduro M.R. reviewed three separate studies on potential new targets to successfully manage endometriosis in her recent paper titled “Novel Strategies to Fight Endometriosis” published in the journal Reproductive Sciences. In the autotransplantation rat model of Torres-Reveron et al., the…

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Cosmetics and some household products could be responsible for worsening endometriosis.

Cosmetics and some household products could be responsible for worsening endometriosis. By Selma Oransay

A controlled clinical study recently published in the Journal of Human Reproductive Sciences,  composed by Nazir et al. from the University of Health Sciences, Lahore, Pakistan. The study compared the blood diethyl hexyl phthalate (DEHP) levels of fifty infertile women laparoscopically diagnosed…

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Transvaginal ultrasound for "rectosigmoid endometriosis" diagnosis: Is bowel preparation necessary?

Transvaginal ultrasound for By Hale Goksever Celik

Rectosigmoid endometriosis is a severe form of deep endometriosis. Women having rectosigmoid endometriosis present with pain and several intestinal complains such as constipation, diarrhea, intestinal cramping, abdominal bloating, feeling of incomplete evacuation, the passage of mucus and rectal bleeding during…

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Toxic Pelvic Cavity and Infertility

Toxic Pelvic Cavity and Infertility By Murat Osman

Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterine cavity and has an incidence of approximately 10% in women of reproductive age. Thus, it is an important consideration in chronic pelvic pain and infertility…

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Reduced pain and increased fertiliy rates after surgery for colorectal endometriosis

Reduced pain and increased fertiliy rates after surgery for colorectal endometriosis By Selma Oransay

This prospective cohort study which recently published in AOGS by Hudelist et al. from Oslo University, Norway is about their one hundred thirty-four laparoscopic operations of DIE cases performed between 2011 and  2016, in a tertiary center in Oslo. The…

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IVF Is the Best Option to Become Pregnant for Women with Severe Endometriosis, or Is It Not?

IVF Is the Best Option to Become Pregnant for Women with Severe Endometriosis, or Is It Not? By Özge Özkaya

Treating rectal endometriosis with surgery seems to increase the chance of a woman conceiving, with most pregnancies occurring naturally. This is according to a study published in the medical journal Human Reproduction.  The optimal treatment for women with severe endometriosis…

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Endometrioma and endometriosis

Endometrioma and endometriosis By Irem Onur

Exacoustos C. et al. published an article titled “The isolated ovarian endometrioma: a history between myth and reality” in the Journal of Minimally Invasive Gynecology in 2018. They aimed to examine the association between ovarian endometriomas detectable at the transvaginal ultrasound…

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How to evaluate ureteral endometriosis : A review of the literature

How to evaluate ureteral endometriosis :  A review of the  literature By Selma Oransay

In this recently published review of the literature, Barra et al. from Genova, Italy intend to provide a useful tool to guide physicians in the management of deep infiltrating endometriosis. Authors elected 67 abstracts from Pubmed and Medline in accordance with PRISMA…

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Comorbidity Risks Among Women with Endometriosis

Comorbidity Risks Among Women with Endometriosis By Deniz Kocas

Evidence demonstrates that endometriosis is associated with higher rates of conditions such as ovarian and other gynecological cancers, thyroid cancer, autoimmune diseases, asthma/atopic diseases, and cardiovascular diseases. However, as findings remain fragmented, there is a need to assess these associations…

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Endometriosis in adolescents

Endometriosis in adolescents By Irem Onur

Dr. Mama S. T. from Cooper University Hospital, Camden, New Jersey, USA, recently has published his review on advances in the management of endometriosis in the adolescent in the journal “Current Opinion Obstetrics and Gynecology”. In adolescence, there is a…

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A Better Way to Diagnose Endometriosis?

A Better Way to Diagnose Endometriosis? By Özge Özkaya

Three proteins found in the blood and endometrial tissues could be used to determine the stage of endometriosis and the severity of painful periods according to a study published in the journal Current Medical Science. Evaluating the levels of these…

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Pain and emotion regulation predict health-related quality of life

Pain and emotion regulation predict health-related quality of life By Deniz Kocas

Studies have established that pain in endometriosis is negatively correlated with HRQL and that endometriosis is associated with psychological problems, anxiety, depression, distress and poor coping ability. It has been observed that some mental conditions associated with endometriosis are modulated…

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Endometriosis as a chronic disease: The benefits for the patients

Endometriosis as a chronic disease: The benefits for the patients By Selma Oransay

Rebecca O'Hara et al. from Monash University, Melbourne, Australia, recently published their qualitative case study in the Journal "Australian Health Review", to build a National Policy about endometriosis considering as a chronic disease.    In Australia, long-term complex diseases are managed…

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How are endometriosis patients managed clinically?

How are endometriosis patients managed clinically? By Irem Onur

This review paper by Falcone and Flyckt, entitled “Clinical Management of Endometriosis” published in the journal Obstetrics & Gynecology aims to summarize the current strategies for treating endometriosis patients with pain, pelvic dysfunction, and subfertility related to their disease. There are many…

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FDA Approves Endometriosis Pain Treatment

FDA Approves Endometriosis Pain Treatment By Özge Özkaya

The U.S. Food and Drug Administration (FDA) approved a new medication for the treatment of moderate to severe pain associated with endometriosis, making it the first treatment to be approved in 10 years. The decision was announced in the Journal…

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A Balancing Act: How Endometriosis Invades the Body

A Balancing Act: How Endometriosis Invades the Body By Murat Osman

Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterine cavity. Ectopic endometrial tissues have been shown to have some features that mimic malignancy. For example, endometriosis can invade surrounding structures and attach to surfaces such…

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A Tool That Goes Where No One Has Gone Before

A Tool That Goes Where No One Has Gone Before By Kasthuri Nair

Vitral et al., researchers from the Federal University of Juiz de Fora, recently published a paper in the World Journal of Nuclear Medicine titled “Use of radioguided surgery in abdominal wall endometriosis: An innovative approach.” The publication focused on a…

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Should I Have Surgery Before Trying to Conceive?

Should I Have Surgery Before Trying to Conceive? By Özge Özkaya

The presence of rectouterine nodules is associated with a lower chance of becoming pregnant with in vitro fertilization (IVF), according to a study published in the Journal of Gynecology Obstetrics and Human Reproduction. This finding is important as it can…

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The vaginal delivery rate of singleton term pregnancies still remains the same after total deep infiltrating endometrosis excisions

The vaginal delivery rate of singleton term pregnancies still remains the same after total deep infiltrating endometrosis excisions By Selma Oransay

This recently published report in the Journal of Fertility Sterility is planned as a  matched case-control study, by Nirgianakanis et al. from the University of Bern, Switzerland. Authors claimed their study is the first because previous studies on pregnancy outcome after laparoscopic…

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Prior endometriosis surgery and the risk of pregnancy complications

Prior endometriosis surgery and the risk of pregnancy complications By Irem Onur

Koninckx et al. discussed the association of pregnancy complications with endometriosis and endometriosis surgery in their recently published paper in the journal Fertility and Sterility. They especially mentioned about the retrospective study of Nirgianakis et al. published in the same…

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Women recommended laparoscopy for chronic pelvic pain

Women recommended laparoscopy for chronic pelvic pain By Irem Onur

Chronic pelvic pain is a diagnostic and therapeutic dilemma. It has many etiologies in many organ systems. Clinician and patient factors affect the management of chronic pelvic pain. Mirowska-Allen K.L. et al. have recently published an article titled, “The characteristics of…

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Vitamin C supplementation in the patients with endometriosis undergoing in vitro fertilization-embryo transfer

Vitamin C supplementation in the patients with endometriosis undergoing in vitro fertilization-embryo transfer By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Women having endometriosis present with dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Thus, infertility remains a significant problem for women with endometriosis. Endometriosis is…

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Questionnaire based evaluation of sexual life after laparoscopic surgery for endometriosis

Questionnaire based evaluation of sexual life after laparoscopic surgery for endometriosis By Deniz Kocas

Researchers from Denmark note that laparoscopic surgery is being increasingly used for the treatment of endometriosis due to its safety and effectiveness. However, treatment success is often evaluated through follow-up on the experience of pain, leaving other important aspects of…

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Complementary treatments for endometriosis symptoms: acupuncture, exercise, electrotherapy, or yoga?

Complementary treatments for endometriosis symptoms: acupuncture, exercise, electrotherapy, or yoga? By Yu Yu

Endometriosis is associated with debilitating symptoms in some women including dysmenorrhea, chronic pelvic pain, deep dyspareunia, dyschezia, and dysuria. There are a few therapeutic options to treat these symptoms; however, only a few studies have considered treating the pain symptoms…

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Coumarin based compounds found to inhibit the estradiol synthesis pathway

Coumarin based compounds found to inhibit the estradiol synthesis pathway By Murat Osman

Endometriosis is a disease characterized by ectopic endometrial tissue outside the endometrium. Several biochemical and molecular pathways have been researched and used to alleviate endometriosis symptoms by inhibiting key molecules involved in the menstrual cycle. This review paper by Niinivehmas…

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The diagnostic value of “sliding sign” and direct visualization of the bowel in rectal/rectosigmoid deep endometriosis

The diagnostic value of “sliding sign” and direct visualization of the bowel in rectal/rectosigmoid deep endometriosis By Hale Goksever Celik

Deep endometriosis is the presence of endometrial subperitoneal implants of ≥5 mm localized in the rectum/rectosigmoid bowel, uterosacral ligaments, rectovaginal septum, vagina and/or bladder. The most common diagnostic screening methods are the transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI)…

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Is there a new hope for the prevention of endometriotic invasions?

Is there a new hope for the prevention of endometriotic invasions? By Selma Oransay

This research which recently published in Biomed Research International is performed by Xiaomei et al. from Obst/Gyn, Pathology and Genetic departments of three hospitals in Changsha, CHINA. The authors planned a prospective and controlled biochemical study to specify the role…

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Fluorescence Guided Surgery: a New Technique to Treat Deep Infiltrating Endometriosis

Fluorescence Guided Surgery: a New Technique to Treat Deep Infiltrating Endometriosis By Özge Özkaya

Fluorescence-guided surgery could help differentiate recto-vaginal deep infiltrating endometriosis nodules (RVDIEN) from healthy rectal tissue and remove them successfully without perforating the rectum, according to a study published in the scientific journal Surgical Innovation.  The method could offer a better,…

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The role of peritoneal washings in the diagnosis of endometriosis

The role of peritoneal washings in the diagnosis of endometriosis By Irem Onur

Endometriosis is a common entity seen in the gynecologic tract and pelvic surfaces. It may be frequently asymptomatic and/or undiagnosed at the time of gynecologic surgery. Pathologists diagnose endometriosis based on the presence of at least two of the following elements: endometrial glands,…

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“Free butterflies will come out of these deep wounds”: A grounded theory of how endometriosis affects women’s psychological health

“Free butterflies will come out of these deep wounds”: A grounded theory of how endometriosis affects women’s psychological health By Deniz Kocas

Researchers from the Catholic University of Milan and the University of Milan note in Journal of Health Psychology that although qualitative research describes the negative impact of endometriosis on quality of life and psychological well-being, studies that analyze individual differences…

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How to improve the current ASRM classification of endometriosis?

How to improve the current ASRM classification of endometriosis? By Selma Oransay

In this article which recently published in Best Practice&Research Clinical Obst&Gyn.  from the University of Sao Paulo, Brazil, Andres et al.  penned a review of the classification of endometriosis in chronological order, and discussed the limitations of existing classification systems to…

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CARD10 and CARD11 Mutations: Another Piece of the Puzzle

CARD10 and CARD11 Mutations: Another Piece of the Puzzle By Kasthuri Nair

Zou et al., a research group from China, recently published a study titled “Analysis of CARD10 and CARD11 somatic mutations in patients with ovarian endometriosis” in Oncology Letters. The paper looked at the effects of caspase recruitment domain family member…

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Oxidative Stress and Endometriosis

Oxidative Stress and Endometriosis By Murat Osman

Endometriosis is a disease characterized by ectopic endometrial tissue outside the endometrium and is associated with a background of a chronic inflammation. Recent studies have aimed to elucidate the inflammatory mediators involved in endometriotic lesions by studying immune cell interactions,…

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3,6-DHF suppresses the invasive properties of endometrial stromal cells through the Notch signaling

3,6-DHF suppresses the invasive properties of endometrial stromal cells through the Notch signaling By Dr. Youngran Park

Dr. Zhou group reported recently that 3,6-DHF can inhibit the development of EMT, migration, and invasion of endometrial stromal cells by inhibiting the Notch signaling pathway. Endometriosis is a condition in which the layer of tissue (glands and mesenchyme) that normally…

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Impact of coping strategies on quality of life of adolescents and young women with endometriosis.

Impact of coping strategies on quality of life of adolescents and young women with endometriosis. By Deniz Kocas

González-Echevarría et al. report in J Psychosom Obstet Gynaecol. that symptoms caused by endometriosis have been found to be associated with negative quality of life (QoL) in women with endometriosis and the type of coping strategies adopted by patients have been shown…

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Can we predict the complexity of laparoscopic surgery by ultrasound?

Can we predict the complexity of laparoscopic surgery by ultrasound? By Selma Oransay

This is a multicentric, retrospective cohort study recently published in the Journal of Minimally Invasive Gynecology by Tompsett et al. in which the results of the transvaginal ultrasonographic examinations (TVS) are compared to the results of the laparoscopic operations performed…

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Could the Sleep Hormone Treat Endometriosis?

Could the Sleep Hormone Treat Endometriosis? By Özge Özkaya

Melatonin blocks cell proliferation, invasion, and migration in both normal and endometriotic epithelial cells, according to a study published in the scientific journal Reproductive Biology and Endocrinology. Melatonin could, therefore, be a potential treatment for endometriosis  The formation and progression…

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Health-related quality of life in women with Endometriosis and Rheumatoid Arthritis

Health-related quality of life in women with Endometriosis and Rheumatoid Arthritis By Murat Osman

Endometriosis is a chronic inflammatory disease that is defined by the presence of ectopic endometrial tissue outside of the uterus. Unfortunately, endometriosis continues to be a leading cause of chronic pelvic pain and long-term morbidity in women of reproductive age.…

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Thoracic Endometriosis Syndrome (TES): Diagnosis by cytology of pleural effusion

Thoracic Endometriosis Syndrome (TES): Diagnosis by cytology of pleural effusion By Nasuhi Engin Aydin

Parikshaa Gupta and colleagues from Chandigarh, India report a case of thoracic endometriosis diagnosed primarily by pleural fluid cytology in a most recent article at Cytopathology. A 33-year-old female presented with a long history of recurrent bouts of chest pain…

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Endometriosis Development: Pathogenesis and genomics

Endometriosis Development: Pathogenesis and genomics By Selma Oransay

In this review recently published in the International Journal of Molecular Sciences, Baranow et al from Saint Petersburg, Russia,  hypothesize the existence of an endometriosis development genetic program (EMDP) that governs the origin of endometrium stem cells programmed for endometriosis; their transition…

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The association between endometriosis, adenomyosis and preterm delivery

The association between endometriosis, adenomyosis and preterm delivery By Hale Goksever Celik

Endometriosis and adenomyosis are diseases of the same spectrum which have common features and coexist in some but not all patients. Both diseases are characterized by endometrial implants outside of the uterine cavity. Endometriosis is defined as the localization of…

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Polymorphism of IL12B May Help Solve Endometriosis

Polymorphism of IL12B May Help Solve Endometriosis By Kasthuri Nair

Zhao et al. recently published a paper titled “A functional promoter polymorphism in interleukin 12B gene is associated with an increased risk of ovarian endometriosis” in Gene. The research group from Hebei Medical University wanted to explore the potential roles…

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A Doctor's Guide to Making Endometriosis Less Scary

A Doctor's Guide to Making Endometriosis Less Scary By Kasthuri Nair

Canis, Bourdel, and Chauvet, doctors from CHU Estaing, recently published an article titled “Endometriosis: frightening the patients is not an acceptable alternative to inadequate surgical management and or pathophysiology ignorance” in Fertility and Sterility. Their paper delineated proper health practices…

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Personalised Medicine for Endometriosis?

Personalised Medicine for Endometriosis? By Özge Özkaya

The lining of the uterus of women with endometriosis is different from that of women without the disease even if they have chronic pelvic pain found a study published in the scientific journal Biology of Reproduction. The difference is found…

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Is there a definitive guideline for the surgical management of endometriosis?

Is there a definitive guideline for the surgical management of endometriosis? By Murat Osman

Endometriosis is a chronic inflammatory disease that is defined by the presence of ectopic endometrial tissue outside of the uterus. Unfortunately, endometriosis continues to be a leading cause of chronic pelvic pain in women of reproductive age. This article titled,…

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Predictors of psychological distress

Predictors of psychological distress By Deniz Kocas

Studies have now established that endometriosis can negatively impact mental health and quality of life, however, some studies show that not all women with endometriosis are necessarily more distressed than healthy women. This suggests that individual differences may explain women’s’…

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Key to Understanding Ovarian Endometriosis may lay in the Peptides

Key to Understanding Ovarian Endometriosis may lay in the Peptides By Kasthuri Nair

Xue et al. recently published a paper titled “Peptidomic Analysis of Endometrial Tissue from Patients with Ovarian Endometriosis” in Cellular Physiology and Biochemistry. The research group from various departments of Nanjing Medical University wished to better understand the pathogenesis of…

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How do adolescent girls and boys perceive symptoms suggestive of endometriosis among their peers?

How do adolescent girls and boys perceive symptoms suggestive of endometriosis among their peers? By Dr. Youngran Park

Endometriosis, a chronic condition characterized by cells similar to the uterine lining that exist outside of the uterus, is estimated to impact 10% of women of reproductive age. In the USA, that approximates to some 7.4 million women. Endometriosis has…

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Inflammatory molecules promote the migration and invasion of endometriosis cells

Inflammatory molecules promote the migration and invasion of endometriosis cells By Yu Yu

Increasing scientific evidence has shown that the immune and inflammatory mechanisms play a central role in the progression of endometriosis by allowing a permissive environment that allows migration, adhesion, proliferation, and invasion of endometrial cells in ectopic regions of the…

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What is being done to help surgeons detect endometriosis during laparoscopy

What is being done to help surgeons detect endometriosis during laparoscopy By Murat Osman

The gold standard for the diagnosis of endometriosis is diagnostic laparoscopy and histologic confirmation. During laparoscopy, visualization of as many lesions as possible may hold better long-term clinical outcomes. Peritoneal endometriosis is difficult to diagnose intraoperatively due to the heterogeneity…

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Effectiveness of the Endometriosis Symptom Diary

Effectiveness of the Endometriosis Symptom Diary By Kasthuri Nair

Seitz et al., a research group from Bayer AG and the University of Giessen, recently published an article titled “Patterns of missing data in the use of the endometriosis symptom diary” in BMC Women's Health. The authors were analyzing data…

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Fallopian Tube Capability in Women with Pelvic Endometriosis and Adenomyosis

Fallopian Tube Capability in Women with Pelvic Endometriosis and Adenomyosis By Kasthuri Nair

Xia et al. recently published a paper titled “Effects of pelvic endometriosis and adenomyosis on the ciliary beat frequency and muscular contractions in the human fallopian tube” in Reproductive Biology and Endocrinology. This research group primarily from Shanghai Jiaotong University…

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The comparison of Chinese women in terms of risk factors, genetics and treatment of endometriosis

The comparison of Chinese women in terms of risk factors, genetics and treatment of endometriosis By Hale Goksever Celik

Endometriosis is characterized by endometrial implants outside of the uterine cavity. There is a wide spectrum of symptoms of this disease including dysmenorrhea, chronic pelvic pain, dyspareunia, extragenital symptoms. The pathogenesis of endometriosis appears to be multifactorial, including ectopic endometrial…

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Link Between Type of Endometriosis and Cancer

Link Between Type of Endometriosis and Cancer By Özge Özkaya

The type of endometriosis a woman has could determine her risk of gynecologic cancer, according to a study published in the journal Obstetrics & Gynecology. This is important because it means that those women who are at a higher risk…

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Elevated levels of adrenomedullin in eutopic endometrium and plasma from women with endometriosis.

Elevated levels of adrenomedullin in eutopic endometrium and plasma from women with endometriosis. By Dr. Youngran Park

Endometriosis is a common gynecologic disease characterized by the presence of endometrial tissue outside of the eutopic endometrium, commonly in the peritoneum of the pelvis and in pelvic organs, and often causing scarring and pain. The nonspecific nature of endometriosis…

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Pain cognition and pain intensity are negatively associated with health-related quality of life

Pain cognition and pain intensity are negatively associated with health-related quality of life By Deniz Kocas

Pain is a personal experience and is different for every individual. Catastrophizing, fear of pain, and hypervigilance to pain are important factors that contribute to pain perception. These factors are described as pain cognition and refer to the negative appraisal…

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Catching Endometriosis Early

Catching Endometriosis Early By Kasthuri Nair

Li et al., a group primarily from Sun Yat-sen University in the People’s Republic of China, recently published an article titled “Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages” in Reproductive Biology and Endocrinology. The…

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New Target for Endometriosis Treatment?

New Target for Endometriosis Treatment? By Özge Özkaya

NR4A1 could be a novel target for the treatment of endometriosis, according to a study published in the scientific journal Cell Physiology and Biochemistry. NR4A1 is a receptor protein involved in cell division, inflammation, and programmed cell death. The development…

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A prospective cohort study examining meat and fish consumption and endometriosis risk.

A prospective cohort study examining meat and fish consumption and endometriosis risk. By Dr. Youngran Park

Endometriosis is a benign, estrogen-dependent, gynecologic condition with a prevalence of ~10% in women of reproductive age. There has been an increased interest in the identification of modifiable risk factors for endometriosis including diet. Diet may influence endometriosis risk through…

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Contraceptives for the management of endometriosis pain

Contraceptives for the management of endometriosis pain By Murat Osman

Endometriosis is a common gynecologic disease that affects many women of reproductive age and is associated with significant morbidity. One of the treatment options for women with endometriosis is the use of oral contraceptives (OCPs) for pain management. However, its…

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Ambiguous experience: Destructive or Constructive

Ambiguous experience: Destructive or Constructive By Deniz Kocas

A diagnostic delay of 4-12 years is reported among women with endometriosis, which is explained by the lack of awareness of endometriosis as a medical condition among patients and healthcare professionals. In searching for a diagnosis, patients encounter many healthcare…

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Endometriosis in a Man as a Rare Source of Abdominal Pain

Endometriosis in a Man as a Rare Source of Abdominal Pain By Dr. Youngran Park

Endometriosis occurs when a tissue resembling endometrial glands and stroma grows in ectopic sites, commonly causing infertility and pain. Endometriosis has largely been found in women of reproductive age. However, in extremely rare cases, it is also found in men…

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Patient-centered endometriosis care

Patient-centered endometriosis care By Hale Goksever Celik

Endometriosis is defined as endometrial glands and stroma that exist outside the uterine cavity. Ectopic endometrial tissue and resultant inflammation can cause dysmenorrhea, dyspareunia, chronic pain, and infertility, all of which reduce the quality of life. The aim of the…

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A clearer picture of "endometriosis after menopause"

A clearer picture of By Irem Onur

Delfin Avendano Tan and Marie Josephine Guanlao Almeria are obstetrician-gynecologists from the Philippines. They recently published a review article titled "Postmenopausal endometriosis: drawing a clearer picture". In this paper, the authors discussed the pathogenesis, risk factors, and management of postmenopausal…

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How Artificial Intelligence Can Improve Our Understanding of the Genes Associated with Endometriosis.

How Artificial Intelligence Can Improve Our Understanding of the Genes Associated with Endometriosis. By Dr. Youngran Park

Endometriosis is a disease characterized by the development of endometrial tissue outside the uterus. A number of studies have shown that endometriosis could have a genetic basis and numerous genes have been studied and proposed to help explain its pathogenesis.…

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Psychosocial impact of endometriosis

Psychosocial impact of endometriosis By Deniz Kocas

In this review article, researchers from Switzerland report a review to outline the consequences of endometriosis on the psychological, sexual, and interpersonal functioning of both patients and their partners, in the journal Best Practice & Research Clinical Obstetrics and Gynecology.…

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Therapeutic strategies involving uterine stem cells in reproductive medicine

Therapeutic strategies involving uterine stem cells in reproductive medicine By Murat Osman

Stem cells are undifferentiated cells that often serve to regenerate tissue in states of injury or apoptosis. The endometrium has progenitor cells that replace tissue lost after each menstrual cycle. It has been postulated that excessive stem cell recruitment to…

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Abnormal Regulation of Pathways Seen in Endometriosis

Abnormal Regulation of Pathways Seen in Endometriosis By Kasthuri Nair

Sikora et al., a team from the Medical University of Silesia in Katowice, published a study in the Archives of Gynecology and Obstetrics titled “The role of complement components C1q, MBL and C1 inhibitor in the pathogenesis of endometriosis.” It has been said that complement system…

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Stenoses in the colorectal anastomose sites after DIE surgery

Stenoses in the colorectal anastomose sites after DIE surgery By Hale Goksever Celik

Deep infiltrating endometriosis (DIE) is a particular form of endometriosis that penetrates at least 5 mm under the peritoneal surface. DIE is primarily located in the rectosigmoid junction and the rectum with an incidence of 70% and 90%, respectively. The…

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A Way to Better Diagnose Colorectal Endometriosis

A Way to Better Diagnose Colorectal Endometriosis By Özge Özkaya

Combining magnetic resonance imaging (MRI) with computed tomography-based virtual colonoscopy (CTC) can make the assessment of colorectal endometriosis more accurate. This is important because it can help doctors plan the surgery better and inform their patients. In order to evaluate…

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Non-coding RNAs in endometriosis

Non-coding RNAs in endometriosis By Dr. Youngran Park

The pathophysiological mechanisms causing the development of endometriosis, which is a heterogeneous disease remain enigmatic, and a lack of effective biomarkers necessitates surgical intervention for diagnosis. Non-coding RNA (ncRNA) molecules, which are important regulators of cellular function, have been implicated…

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Deep Infiltrating Endometriosis Impairs Sexual Function

Deep Infiltrating Endometriosis Impairs Sexual Function By Kasthuri Nair

Lima et al., a group of scientists from Hospital do Servidor Público Estadual in Brazil, recently published an article entitled “Female Sexual Function in Women with Suspected Deep Infiltrating Endometriosis” in Revista Brasileira De Ginecologia E Obstetricia. The paper analyzed…

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Emerging medical treatments for endometriosis

Emerging medical treatments for endometriosis By Murat Osman

Endometriosis is a disease whereby uterine tissue grows outside the walls of the uterus to the surfaces of other tissues in the body. It is a chronic disease and relies upon estrogen to grow and survive. Current medical therapies take…

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Role of GATA6 in Endometriosis

Role of GATA6 in Endometriosis By Özge Özkaya

Researchers discovered that a protein called GATA6 is crucial in turning endometrial stromal cells into endometriotic-like cells, which may be capable of invading surrounding tissues and growing outside the uterus.  This knowledge can be used to create cell models that…

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Is the Endometriosis Fertility Index Reliable?

Is the Endometriosis Fertility Index Reliable? By Kasthuri Nair

Zhang et al. recently published a paper titled “Prediction of Endometriosis Fertility Index in patients with endometriosis-associated infertility after laparoscopic treatment” in Reproductive BioMedicine Online. The research group from the West China Second University Hospital in Sichuan University wanted to…

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Could Endometriosis Be Caused by Bacteria?

Could Endometriosis Be Caused by Bacteria? By Özge Özkaya

A new concept called the bacterial contamination hypothesis in endometriosis has been proposed for the first time by researchers in Japan. This means that new potential therapies approaches could exist for this condition in addition to the conventional estrogen-suppressing therapies.…

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Exosomal miR-214 from endometrial stromal cells inhibits endometriosis fibrosis.

Exosomal miR-214 from endometrial stromal cells inhibits endometriosis fibrosis. By Dr. Youngran Park

Fibrosis is an important pathological feature of endometriosis. Novel therapies targeting the mechanisms of fibrosis in endometriosis are indispensable for the development of strategies to prevent and treat endometriosis. Previous microarray studies have detected some miRNAs that are aberrantly expressed…

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Extending the Female Fertility Clock

Extending the Female Fertility Clock By Kasthuri Nair

Varela, Sanchez-de-Puerta, and Garcia-Velasco are a group of scientists from various institutions in Spain and they recently published a review article titled “Fertility, IVF and reproductive genetics” in Current Opinion in Obstetrics and Gynecology. In this publication, the authors discussed…

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Thoracic Endometriosis Syndrome : A case report describing endometriosis involvement of the lung

Thoracic Endometriosis Syndrome : A case report describing endometriosis involvement of the lung By Murat Osman

Leonardo-Pinto and authors from the Universidade Estadual de Campinas, Brazil, have recently published a case report titled, "Hemoptysis and Endometriosis: An Unusual Association - Case Report and Review of the Literature" in the Journal, Revista Brasileira De Ginecologia E Obstetricia describing a…

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S100A6 May be a Promising Target for Endometriosis Treatments

S100A6 May be a Promising Target for Endometriosis Treatments By Kasthuri Nair

Peng et al., a group primarily from the Zhejiang University Medical College, recently published a paper in Gynecological Endocrinology titled “Upregulation of S100A6 in patients with endometriosis and its role in ectopic endometrial stromal cells.” This paper delineates a study…

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HOXA10: A Culprit in Endometriosis Disease Progression

HOXA10: A Culprit in Endometriosis Disease Progression By Kasthuri Nair

Zheng et al., a group of authors from the Aerospace Center Hospital in Bejing and from the First Affiliated Hospital of Wenzhou Medical University in Wenzhou, recently published a paper in Reproductive Sciences entitled “Decreased Expression of HOXA10 May Activate the…

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Endometriosis surgery and preservation of fertility, what surgeons should know

Endometriosis surgery and preservation of fertility, what surgeons should know By Murat Osman

Endometriosis can involve most of the pelvic organs including the uterus, ovaries and fallopian tubes and thus has the potential to cause infertility. This article titled, “Endometriosis surgery and preservation of fertility, what surgeons should know” written by H. Roman…

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The use of retinoic acid for the treatment of endometriosis

The use of retinoic acid for the treatment of endometriosis By Murat Osman

Endometriosis is one of the leading causes of chronic pelvic pain in women during their childbearing years. Several drugs have been researched to either reduce inflammation, decrease growth, or kill endometriotic cells. Retinoic acid (Vitamin A) is one such molecule…

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No Link Found Between Vitamin D and Endometriosis

No Link Found Between Vitamin D and Endometriosis By Kasthuri Nair

Buggio et al., a group of scientists from the Ospedale Maggiore Policlinico, Universita` degli Studi in Milan, recently published a paper in the Reproductive Sciences titled “25-Hydroxyvitamin D Serum Levels and Endometriosis: Results of a Case-Control Study.” The publication sought…

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Endometriosis From an Epigenetic Lens

Endometriosis From an Epigenetic Lens By Kasthuri Nair

Samadieh et al. from the Royan Institute for Reproductive Biomedicine, recently published an article in Reproductive Sciences titled “Epigenetic Dynamics of HOXA10 Gene in Infertile Women With Endometriosis.” In this paper, the researchers wanted to observe HOXA10 gene expression in…

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Direct shedding of endometrioma contents visualized by ultrasonography

Direct shedding of endometrioma contents visualized by ultrasonography By Murat Osman

Endometriosis is one of the leading causes of chronic pelvic pain in women during their childbearing years. Researchers from Italy have recently published a case report in the European Journal of Obstetrics & Gynecology and Reproductive Biology observing the direct shedding of endometriotic…

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Exercise can improve pelvic pain and posture associated with endometriosis

Exercise can improve pelvic pain and posture associated with endometriosis By Yu Yu

Nearly half of women affected by endometriosis have mild to severe chronic pelvic pain (CPP). Clinically, postural changes are frequently seen in CPP sufferers. These postural changes can include uneven positions, shortenings, antalgic postures, and tensions. Moreover, endometriosis is also…

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Treatment of Endometriosis in Adolescents

Treatment of Endometriosis in Adolescents By Özge Özkaya

Most women with endometriosis who have been treated with Lupron plus add back as adolescents felt the treatment was effective in reducing the pain caused by the condition, according to a study published in the Journal of Pediatric & Adolescent…

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Picture This: 8K UHD Television System for Endometriosis Surgery

Picture This: 8K UHD Television System for Endometriosis Surgery By Kasthuri Nair

This case report by Aoki et al. was published in the journal "Videosurgery and Other Miniinvasive Techniques" under the title “Effect of an 8K ultra-high-definition television system in a case of laparoscopic gynecologic surgery.” In this publication, the authors delineated…

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Using the "Mushroom Cap" sign to describe endometriotic masses

Using the By Murat Osman

Endometriosis is a disease whereby ectopic endometrial cells attach and grow outside of the uterus. A number of imaging techniques have been used to evaluate and assess endometriotic lesions. Magnetic resonance imaging (MRI) is a type of imaging modality used…

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Endocrine and inflammatory factors in current understanding of endometriosis

Endocrine and inflammatory factors in current understanding of endometriosis By Yu Yu

There are three forms of endometriosis: peritoneal, ovarian, and deep infiltrating. All three forms consist of endometriotic lesions containing endometrial glands, stroma, nerves, blood vessels, and inflammatory cells. Endometriosis symptoms can be accounted by these elements and the involving organs.…

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Adolescents with Endometriosis are More Susceptible to Migraines

Adolescents with Endometriosis are More Susceptible to Migraines By Kasthuri Nair

Miller et al. recently published an article titled “The prevalence of migraines in adolescents with endometriosis” in Fertility and Sterility. The main purpose of the study was to determine if adolescents with endometriosis experience more migraines than those without endometriosis.…

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Endometrial stem cells and Endometriosis

Endometrial stem cells and Endometriosis By Dr. Youngran Park

Human endometrium is a cyclically proliferative tissue, and this monthly regeneration is likely mediated by endometrial stem (or progenitor) cells.The upper functional layer of the endometrium breaks down and is shed into the uterine cavity during menstruation. Re-epithelialization and repair…

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Independent development of endometrial epithelium and stroma within the same endometriosis

Independent development of endometrial epithelium and stroma within the same endometriosis By Murat Osman

Endometriosis is one of the leading causes of chronic pelvic pain in women during their childbearing years. A popular theory for the pathogenesis of endometriosis posits that circulating progenitor cells differentiate into the endometrial stroma and glandular tissue once they…

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An Unusual Case "Free Floating Omental Endometrioma"

An Unusual Case By Kasthuri Nair

Capaccione et al. published an article in Radiology Case Reports titled “Massive endometrioma presenting with dyspnea and abdominal symptoms.” This publication is centered around a particularly unique case report of a woman who was ultimately diagnosed with endometriosis. The patient…

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The use of histone deacetylase inhibitors for the treatment of endometriosis

The use of histone deacetylase inhibitors for the treatment of endometriosis By Murat Osman

Histone deacetylase inhibitors prevent the deacetylation of specific gene sequences thereby allowing the increased transcription of certain genes. Trichostatin A, a histone deacetylase inhibitor, has been seen to induce the expression of a pro-apoptotic gene called nonsteroidal anti-inflammatory drug-activated gene…

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Enhanced UGT1A1 Gene and Protein Expression in Endometriotic Lesions.

Enhanced UGT1A1 Gene and Protein Expression in Endometriotic Lesions. By Dr. Youngran Park

The estrogen plays an essential role in endometriosis. Lately, it is becoming evident that, besides the circulating levels of estrogens, the balance of synthesis versus inactivation (metabolism) of estrogens by intralesional steroid-metabolizing enzymes also determines the local net estrogen availability.…

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Recurrence of Deep Infiltrating Endometriosis

Recurrence of Deep Infiltrating Endometriosis By Yu Yu

There are mainly three types of endometriotic lesions. These are ovarian endometriosis, superficial peritoneal endometriosis, and deep infiltrating endometriosis (DIE). The latter is often described as a lesion with greater than 5 mm invasion of the peritoneal surface. DIE lesions…

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A How-To Guide for Endometriosis Surgery

A How-To Guide for Endometriosis Surgery By Kasthuri Nair

The European Society for Gynaecological Endoscopy (ESGE), ESHRE, and the World Endometriosis Society (WES) recently published a document titled “Recommendations for the surgical treatment of endometriosis—part 1: ovarian endometriomas.” This publication provides surgeons with recommendations for the technical aspects of…

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Does Endometriosis Cause Infertility?

Does Endometriosis Cause Infertility? By Özge Özkaya

Infertility may be related to the localization of endometriosis involvement according to a study published in the Journal of Obstetrics and Gynaecology. This finding is in agreement with the results of previous studies and could help clinicians in their decision…

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A review on the role of immune cells on the pathogenesis of endometriosis

A review on the role of immune cells on the pathogenesis of endometriosis By Murat Osman

Immune cells play a vital role in the homeostasis against infectious pathogens but also in the pathogenesis of endometriosis. Recent research has suggested that different immune cells have unique roles in this pathogenesis. Neutrophils, which are typically the primary acute…

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Collaboration Between the Surgical and Medical Experts of Endometriosis Needed

Collaboration Between the Surgical and Medical Experts of Endometriosis Needed By Murat Osman

The authors of this perspective article aim to initiate a dialogue regarding the current evidence regarding the surgical and medical treatment of endometriosis. In their view, the quality of data regarding the outcomes of surgery for endometriosis is lacking and…

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Interleukin 6 secretion from activated macrophages promotes the migration of endometriotic epithelial cells

Interleukin 6 secretion from activated macrophages promotes the migration of endometriotic epithelial cells By Dr. Youngran Park

Endometriosis is a chronic inflammatory disease. Accumulating evidence suggests that endometriosis patients have a higher level of various inflammatory factors which are associated with the pathogenesis of the disease. Several studies have shown marked increases in macrophage populations and activity…

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Ectopic Pregnancy Risk Factors

Ectopic Pregnancy Risk Factors By Kasthuri Nair

Jacob, Kalder, and Kostev recently published an article titled “Risk factors for ectopic pregnancy in Germany: a retrospective study of 100,197 patients” in German Medical Science. The retrospective German study hoped to elucidate the risk factors for ectopic pregnancies. The…

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Inflammatory mediators in endometriosis pathogenesis

Inflammatory mediators in endometriosis pathogenesis By Yu Yu

Proinflammatory cytokines play an important function in mediating inflammatory reactions in chronic inflammatory diseases and in endometriosis. IL-32 is a new proinflammatory cytokine, and can also induce other proinflammatory cytokines in the body such as Tumour Necrosis Factor-α (TNF-α) and…

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The endometrial stem cell markers notch-1 and numb are associated with endometriosis. 

The endometrial stem cell markers notch-1 and numb are associated with endometriosis.  By Dr. Youngran Park

The pathological mechanisms of endometriosis are still poorly understood. However, stem cells have been candidates of interest because of their high proliferation potential and their ability to differentiate into multiple lineages, contributing to characteristic traits of endometriosis. Also, previous studies…

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Endometriosis and its pro-fibrotic nature. 

Endometriosis and its pro-fibrotic nature.  By Dr. Youngran Park

Endometriosis is currently defined as the presence of endometrial epithelial and stromal cells at ectopic sites. However, with advances in disease knowledge, several vital issues challenge this old definition. Especially, endometrial stromal and glands have been shown to represent only…

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Blood vessels formation in endometriosis

Blood vessels formation in endometriosis By Yu Yu

The endometrium undergoes dynamic changes during the menstrual cycle. Estrogen-driven angiogenesis is associated with the proliferative phase, and progesterone-driven vascular maturation occurs in the secretory phase. Hence, it is reasonable that the vascularization of endometriosis is also under complex regulation…

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The effects of MK2206 and chloroquine combination therapy on endometriosis.

The effects of MK2206 and chloroquine combination therapy on endometriosis. By Dr. Youngran Park

Endometriosis affects approximately 10% of women of reproductive age. A high recurrence rate after medical treatment with or without surgery is a significant clinical problem for patients with endometriosis. Establishment of a complete cure for patients with endometriosis awaits new…

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Can Getting Pregnant Make my Pain Go Away?

Can Getting Pregnant Make my Pain Go Away? By Özge Özkaya

The association between pregnancy and symptoms of endometriosis are controversial and strongly biased, and there is no evidence suggesting that pregnancy reduces the size and number of endometriotic lesions, according to a study published in the journal Human Reproduction Update.…

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Which Endometriosis Treatment is Better: NETA or Extended-cycle OC (Seasonique®)?

Which Endometriosis Treatment is Better: NETA or Extended-cycle OC (Seasonique®)? By Kasthuri Nair

Scala et al. recently shared the findings of their patient preference prospective study in a journal article titled “Norethindrone acetate versus extended-cycle oral contraceptive (Seasonique®) in the treatment of endometriosis symptoms: A prospective open-label comparative study,” which was published in the…

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Inhibition of Histone methyltransferase for fighting endometriosis

Inhibition of Histone methyltransferase for fighting endometriosis By Dr. Youngran Park

Although the histone methyltransferase EZH2 and its product H3K27me3 are well studied in cancer, little is known about their role and potential as therapeutic targets in endometriosis. It has been previously reported that the endometriotic lesions are characterized by global…

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Novel lipid biomarkers may make early detection of endometriosis possible

Novel lipid biomarkers may make early detection of endometriosis possible By Murat Osman

Currently, specific clinical diagnostic indicators for the early detection of endometriosis have not been found with enough specificity and sensitivity for widespread use. Novel diagnostic biomarkers are needed that are both effective and non-invasive to detect endometriosis as early as…

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"N-myc Downstream-Regulated Gene 1" and Endometriosis.

By Dr. Youngran Park

NDRG1 is implicated in many different cellular functions such as differentiation, proliferation, migration, invasion, and vascularization. In endometriosis, NDRG1 is identified as an inhibitor of several important pathways. To focus on the potential function of NDRG1 in endometriosis, Lou et…

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Which cell defines endometriosis?

Which cell defines endometriosis? By Murat Osman

A well-accepted theory regarding the pathogenesis of endometriosis hypothesizes that the origin of endometriosis is from peritoneal dissemination of endometrial cells and stroma during the neonatal period or menarche. Varying cellular components of endometriosis have been observed in the setting…

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Skin Endo Diagnosis

Skin Endo Diagnosis By Özge Özkaya

High-frequency ultrasound can be very useful for the early diagnosis of cutaneous endometriosis according to a study published in the journal Skin Research and Technology. The diagnostic tool could be used in patients who have unusual cyclical pain even before…

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Therapeutic Roles of Statins in Gynecology and Obstetrics.

Therapeutic Roles of Statins in Gynecology and Obstetrics. By Dr. Youngran Park

Statins are a class of drugs, which act by inhibiting the rate-limiting enzyme of cholesterol biosynthesis, which reduces lipid production. Therefore, statin has been used for the treatment of hypercholesterolemia and coronary artery disease. This study published in Reproductive Sciences performed…

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A new hypothesis for the origin of endometriosis-associated ovarian cancers

A new hypothesis for the origin of endometriosis-associated ovarian cancers By Murat Osman

Endometriosis has been associated with an increased risk in the development of the clear cell, endometrioid, and low-grade serous tumors. Thus, progression to these forms of type I tumors is associated with endometriosis precursor lesions that are atypical. The transition…

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Long-term Use of Dienogest can Prevent Recurrence of Endometriomas

Long-term Use of Dienogest can Prevent Recurrence of Endometriomas By Kasthuri Nair

Chandra et al. recently published a paper titled “Clinical experience of the long-term use of dienogest after surgery for ovarian endometriomas” in Obstetrics and Gynecology Science. The publication explored the benefits and repercussions associated with long-term use of dienogest, a…

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Are there any risk factor associated with the progression of endometriosis to ovarian cancer?

Are there any risk factor associated with the progression of endometriosis to ovarian cancer? By Murat Osman

Endometriosis is a disease whereby endometrial glands proliferate outside of the endometrial lining. Apart from causing significant morbidity, It has been found that endometriosis is associated with an increased risk of progression to endometroid and clear cell ovarian cancer. However,…

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Is the presence of endometriosis associated with a survival benefit in pure ovarian clear cell carcinoma?

Is the presence of endometriosis associated with a survival benefit in pure ovarian clear cell carcinoma? By Dr. Youngran Park

Ovarian clear cell carcinoma (OCCC) has been known to be associated with endometriosis for a long time. However, the impact of the presence of endometriosis around the tumor on the prognoses of women with OCCC is still controversial. To shed…

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When Endometriosis Becomes Malignant

When Endometriosis Becomes Malignant By Kasthuri Nair

Anglesio and Yong recently wrote a review titled “Endometriosis-associated Ovarian Cancers” that was published in Clinical Obstetrics and Gynecology. This review explored the relationship between endometriosis and ovarian cancers. It is important to note that this review is a compilation of…

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Women with Endometriosis Should Not Worry About Ovarian Cancer

Women with Endometriosis Should Not Worry About Ovarian Cancer By Kasthuri Nair

Kvaskoff, Horne and Missmer recently published an article in The Lancet titled “Informing women with endometriosis about ovarian cancer risk.” This article was written to address the growing concern surrounding the information that women suffering from endometriosis are at increased…

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Intestinal Endometriosis and Colorectal Cancer versus T4 Colorectal Cancer

Intestinal Endometriosis and Colorectal Cancer versus T4 Colorectal Cancer By Kasthuri Nair

Ishii et al. recently published a paper titled “Intestinal endometriosis combined with colorectal cancer: a case series” in the Journal of Medical Case Reports. This case report follows 7 Japanese women who have intestinal endometriosis and colorectal cancer. These women…

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EFA Medical Conference 2017: "Ovarian Cancer" Presentation by  Dr. Jeannine Villella

EFA Medical Conference 2017: By Kasthuri Nair

Dr. Jeannine Villella, the Chair of Gynecologic Oncology in the Department of OBGYN at Lenox Hill, presented at the 2017 EFA Medical Conference. Her presentation was titled “Ovarian Cancer, ” and she discussed the similarities, differences, and links between ovarian…

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Diagnostic and treatment guidelines for gastrointestinal and genitourinary endometriosis.

Diagnostic and treatment guidelines for gastrointestinal and genitourinary endometriosis. By Murat Osman

Endometriosis may affect the pelvic reproductive system, but it can also be found in non-reproductive organs such as the gastrointestinal and urinary tract. The article outlined below discusses the diagnosis and management of genitourinary and gastrointestinal endometriosis. Gastrointestinal endometriosis: The…

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Atypical Sites of Deeply Infiltrative Endometriosis

Atypical Sites of Deeply Infiltrative Endometriosis By Yu Yu

Endometriosis is the presence of endometrial tissue outside the uterine cavity and is characterizes by fibrosis and inflammatory reaction. The pelvic cavity is the most common location for endometriotic lesions, which involves the retro-cervical space, ovaries, vagina, rectosigmoid colon, bladder…

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Epigenetic regulation of the pathological process in endometriosis.

Epigenetic regulation of the pathological process in endometriosis. By Dr. Youngran Park

Epigenetic mechanisms have been recognized as important players in the development of a broad range of human diseases including endometriosis. A growing body of evidence shows that the remodeling of retrograde endometrial tissues to the ectopic endometriotic lesions involves multiple epigenetic…

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How to Improve the Psycho-Social Well Being in Endometriosis Patients?

How to Improve the Psycho-Social Well Being in Endometriosis Patients? By Kasthuri Nair

Endometriosis and its various symptoms can negatively impact an individual’s psycho-social wellbeing.  Additionally, current endometriosis treatments do not adequately alleviate the symptoms and improve a patient’s health-related quality of life (HRQOL). In their article titled “The association between experiences with…

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Laparoscopic Bowel Resection Can Be Beneficial Rectosigmoid Endometriosis

Laparoscopic Bowel Resection Can Be Beneficial Rectosigmoid Endometriosis By Kasthuri Nair

Riiskjær et al. recently published a paper titled “Pelvic Pain and Quality of Life Before and After Laparoscopic Bowel Resection for Rectosigmoid Endometriosis: A Prospective, Observational Study” in Diseases of the Colon & Rectum. This paper focuses on the effects…

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The Use of Resveratrol as an Adjuvant Treatment of Pain in Endometriosis

The Use of Resveratrol as an Adjuvant Treatment of Pain in Endometriosis By Dr. Youngran Park

Endometriosis is considered a predominantly estrogen-dependent disease, and therefore hormonal suppression might be an attractive medical approach to treat this disease and its symptoms. Resveratrol is a natural phytoestrogen synthesized by plants and has known to have side effects such…

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MRI Best at Detecting Intestinal Deep Infiltrating Endometriosis

MRI Best at Detecting Intestinal Deep Infiltrating Endometriosis By Özge Özkaya

Magnetic resonance imaging (MRI) seems to be a better method in identifying deep infiltrating endometriosis in the intestine compared to two-dimensional ultrasonography (2DUS), found a study by researchers in Italy and Spain. However, this does not seem to be the…

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The Deregulated Molecular Functions Involved in Malignant Transformation of Endometriosis to Endometriosis-Associated Ovarian Carcinoma

The Deregulated Molecular Functions Involved in Malignant Transformation of Endometriosis to Endometriosis-Associated Ovarian Carcinoma By Dr. Youngran Park

Endometriosis-associated ovarian cancer (EAOC) is postulated to be transformed from endometriosis. Though different deregulated functional areas were proposed accounting for the pathogenesis of EAOC transformation, there is a lack of data-driven analysis to prove this. To understand the EAOC pathogenesis…

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Does asthma increase the risk of endometriosis?

Does asthma increase the risk of endometriosis? By Demet Candaş Green

Previous studies have shown an association between asthma and endometriosis but with inconsistency. It is still unclear whether women who have asthma are at a higher risk of endometriosis than women without asthma symptoms. Peng et al., conducted a large…

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Estrogen receptor splice variants may be associated with endometriosis pathogenesis and clinical severity.

Estrogen receptor splice variants may be associated with endometriosis pathogenesis and clinical severity. By Murat Osman

Endometriosis is defined as the presence of uterine stroma and glands outside of the uterine cavity and is one of the leading causes of chronic pelvic pain in women. Thus, understanding key genetic markers of this disease and evaluating those…

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How good are the current guidelines on endometriosis? 

How good are the current guidelines on endometriosis?  By Dr. Youngran Park

The endometriosis was first described in 1860, yet the etiology and pathogenesis remain poorly understood. Treatment strategies vary significantly between disease severity and the symptoms of pain and/or subfertility. These challenges have resulted in multidirectional research, and the comparability of…

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Centralization of Pelvic Endometriosis Care

Centralization of Pelvic Endometriosis Care By Kasthuri Nair

Dr. Patrick Chien, the Deputy Editor-in-Chief of BJOG, recently wrote an article titled “Pelvic endometriosis: will centralization of services improve patient care?” In this article, Dr. Chien formulated an opinion on the centralization of pelvic endometriosis care based on the…

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Autophagy in endometriosis

Autophagy in endometriosis By Dr. Youngran Park

Endometriosis is a common gynecologic disease affecting both fertile (5-10%) and infertile (20-50%) women, and it commonly causes chronic pelvic pain, dysmenorrhea, and infertility. Recent research found that the autophagy exerts a pro-apoptotic effect on normal human endometrial cells and…

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The Heritability of Endometriosis

The Heritability of Endometriosis By Kasthuri Nair

The mechanisms underlying endometriosis, genetic or otherwise, have yet to be understood. Thus, very little is known about how one can be afflicted with this disease. Isidor et al. recently published a paper titled “Familial deep endometriosis: A rare monogenic…

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Diagnosis and management of adolescent endometriosis

Diagnosis and management of adolescent endometriosis By Murat Osman

Early onset endometriosis (EOE) is characterized by endometriosis that begins around menarche or early adolescence. Recent evidence suggests that this form of endometriosis may have a different pathogenic origin than that of adult-onset endometriosis. This opinion article suggests that early…

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Can Ovarian Stimulation Increase Endometrioma Volume?

Can Ovarian Stimulation Increase Endometrioma Volume? By Kasthuri Nair

Seyhan et al. recently published a paper titled “Do endometriomas grow during ovarian stimulation for assisted reproduction? A three-dimensional volume analysis before and after ovarian stimulation” in Reproductive BioMedicine Online. The authors initially believe that ovarian stimulation, often used in…

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Detection and diagnosis of deep endometriosis in the clinical setting

Detection and diagnosis of deep endometriosis in the clinical setting By Murat Osman

This review aims to evaluate the contribution of imaging techniques including transvaginal sonography (TVS) and magnetic resonance imaging (MRI) to the diagnosis of deep infiltrating endometriosis (DIE). Endometriosis is defined by the presence of endometrial tissue outside the uterus and…

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Bowel Function not Affected by Type of Surgery in Deep Rectal Endometriosis, Clinical Trial Shows

Bowel Function not Affected by Type of Surgery in Deep Rectal Endometriosis, Clinical Trial Shows By Özge Özkaya

Conservative surgery for the management of deep rectal endometriosis does not seem to improve the function of the digestive and urinary system compared to more radical surgery according to a new study by French researchers published in the scientific journal Human…

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Ectoenzymes as endometriosis biomarkers

Ectoenzymes as endometriosis biomarkers By Yu Yu

The diagnosis of endometriosis is often delayed by 7 to 11 years because of the lack of a non-invasive diagnostic test. The ovarian endometriomas occur in about 17%-44% of women with endometriosis and cysts which contain endometrial tissue and fluid…

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Hormonal Contraceptives and the Risk of Breast Cancer

Hormonal Contraceptives and the Risk of Breast Cancer By Kasthuri Nair

A study titled “Contemporary Hormonal Contraception and the Risk of Breast Cancer” was recently published in The New England Journal of Medicine and was immediately picked up and summarized by many well-known newspapers and broadcasting journals, including but not limited…

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Effects of osteopathic manipulative therapy in patients with colorectal endometriosis

Effects of  osteopathic manipulative therapy in patients with colorectal endometriosis By Laura Ardighieri

Alternative treatments have been used for colorectal endometriosis, between them Chinese medicine, acupuncture and more recently osteopathic manipulative therapy. The osteopathic manipulative therapy has been shown to reduce the chronic pain working on muscular contractions due to vicious analgesic positions.…

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Short-term effects of dienogest on ovarian endometriomas

Short-term effects of dienogest on ovarian endometriomas By Murat Osman

First-line treatment of symptomatic, uncomplicated ovarian endometriosis is the use of progestins with or without estrogens such as Dienogest (DNG). These drugs are used to inhibit ovulation and thus reduce the estrogenic environment in which endometriosis relies upon for survival.…

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How Could Doctors Reduce Risk of Complications Following Rectal Endometriosis Surgery?

How Could Doctors Reduce Risk of Complications Following Rectal Endometriosis Surgery? By Özge Özkaya

Introducing a temporary opening, known as a stoma, in the abdomen of patients that are operated for rectal endometriosis to collect waste products could reduce the risk of complications such as anastomotic leakage. This is according to a study by…

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Endometriosis pathogenesis through the lens of reactive oxygen species

Endometriosis pathogenesis through the lens of reactive oxygen species By Yu Yu

Oxidative stress caused by reactive oxygen species is an essential factor in endometriosis pathogenesis. The harmful effects of reactive oxygen species have been implicated in many diseases, although the multiple biological changes caused is unclear especially in endometriosis. The article…

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Quality of Life in Women with Endometriosis

Quality of Life in Women with Endometriosis By Murat Osman

Endometriosis is a chronic disease characterized by the presence of endometrial tissue outside the uterine cavity. Progression and spread of the disease to other structures may lead to symptoms such as pelvic pain, urinary, and GI dysfunction. Endometriosis has been…

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How to identify an Expert Centers for Colorectal Endometriosis Surgery

How to identify an Expert Centers for Colorectal Endometriosis Surgery By Özge Özkaya

It is of paramount importance to determine set criteria to define expert centers for colorectal endometriosis surgery, according to a research article published in the scientific journal Surgical Endoscopy.  As the hospital and surgeon case volume has a significant impact…

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Investigational Medical Therapies for Endometriosis: Current Data and Future Trends. 

Investigational Medical Therapies for Endometriosis: Current Data and Future Trends.  By Dr. Youngran Park

The medical treatment of endometriosis has traditionally relied on hormonal therapies. Because these hormonal therapies preclude fertility or may have unwanted side effects, there is a great need for novel hormonal and non-hormonal medical options. Therefore, this review focuses on…

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Endometriosis early pointers

Endometriosis early pointers By Yu Yu

Endometriosis can take a long time to diagnose, thus associated with prolonged symptoms of pain, subfertility and patient frustration/demoralization. It can be difficult to diagnose clinically because the symptoms are common and non-specific so that GP can misconceive them as…

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Surgical treatment is an excellent option for women with endometriosis and infertility.

Surgical treatment is an excellent option for women with endometriosis and infertility. By Murat Osman

Women with endometriosis most often have difficulty becoming pregnant and thus require a combination of endometriosis treatment and infertility techniques to achieve pregnancy. Depending on the severity of endometriotic symptoms, women may or may not need surgical excision of endometriosis…

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Autophagy in endometriosis: Friend or foe?  

Autophagy in endometriosis: Friend or foe?   By Dr. Youngran Park

Endometriosis is a chronic, estrogen-dependent disease and affects an estimated 10% of the female population of reproductive age. Unfortunately, the etiology of endometriosis is not clear. Recently emerging evidence shows that there is a close relationship between endometriosis and autophagy.…

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Treatment of minimal endometriosis in infertile women

Treatment of minimal endometriosis in infertile women By Demet Candaş Green

For women with mild/minimal endometriosis, European Society of Human Reproduction and Embryology (ESHRE) recommends the removal of endometriotic lesions to improve fertility and increase pregnancy rates. For women undergoing assisted reproductive treatment, there is ongoing debate whether surgical removal of…

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Progesterone resistance can cause endometriosis

Progesterone resistance can cause endometriosis By Demet Candaş Green

Progesterone is a steroid hormone produced by the corpus luteum of ovaries. Abnormal progesterone signaling (i.e., progesterone resistance) in the endometrium has been implicated in the establishment of eutopic and ectopic endometrial implants. Several causes for faulty progesterone signaling have been…

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EFA Medical Conference 2017: EFA Research Grants Presentation by Dr. Serin Seckin

EFA Medical Conference 2017: EFA Research Grants Presentation by Dr. Serin Seckin By Kasthuri Nair

Dr. Serin Seckin, a Resident Physician at Mount Sinai Health System, gave a presentation during the 2017 Medical Conference titled “EFA Research Grants.” This presentation delineated and went into some detail about the research grants worth over $400,000 that were…

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Endometriosis and Oxidative Stress

Endometriosis and Oxidative Stress By Dr. Youngran Park

The etiology of endometriosis is still unclear. However, it is now widely accepted that oxidative stress, defined as an imbalance between reactive oxygen species (ROS) and antioxidants, may be implicated in the pathophysiology of endometriosis causing a general inflammatory response…

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EFA Medical Conference 2017: "The Environmental Risks of Breast Cancer" Presentation by Dr. Marisa Weiss

EFA Medical Conference 2017: By Kasthuri Nair

The second speaker in the subsection of the conference titled “Estrogen from Inflammation to Cancer: A Distant Link?” was Dr. Marisa Weiss and she gave a presentation titled “The Environmental Risks of Breast Cancer: Common Ground with Endometriosis.” Dr. Weiss…

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Effects of acupuncture for the treatment of endometriosis-related pain

Effects of acupuncture for the treatment of endometriosis-related pain By Murat Osman

Acupuncture has been seen to offer chronic pain relief most likely due to multiple effects including analgesia and anti-inflammatory changes. Current therapy for endometriosis includes pharmacological and surgical methods. Symptom relief using other supplementary therapies such as acupuncture has been…

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Women with Mild Endometriosis May Have a Higher Risk of Miscarriage

Women with Mild Endometriosis May Have a Higher Risk of Miscarriage By Özge Özkaya

Mild endometriosis presents an increased risk of miscarriage according to a new study published in the scientific journal Fertility and Sterility.  Researchers think that this may be because superficial lesions are associated with a greater extent of the inflammatory disorder, which may lead…

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The role of the B lymphocytes in endometriosis: A systematic review

The role of the B lymphocytes in endometriosis: A systematic review By Murat Osman

Insight into the role of an inflammatory response in endometriosis has sparked further study into the role of different immune cells and their causal relationship to the pathogenesis of endometriosis. Several recent studies have found an association between aberrant immune…

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Highlights from the Endometriosis Foundation of America Medical Conference

Highlights from the Endometriosis Foundation of America Medical Conference By Özge Özkaya

The Endometriosis Foundation of America (EFA)’s 2017 Medical Conference was held in New York City on October 28. The conference titled “Breast, Ovary, and Endometriosis” was attended by more than 100 people and viewed online by more than 5.300. Following…

Lay Summary

Revisiting the wandering womb: Oxytocin in endometriosis and bipolar disorder

Revisiting the wandering womb: Oxytocin in endometriosis and bipolar disorder By Dr. Youngran Park

Despite a Hysteria (from Greek hysterikos, meaning ‘of the womb’) was dismissed as causing mental illness, recent evidence links oxytocin with diverse and correlated psychological and physical symptoms and conditions that more frequently affect women than men. This article proposes…

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Biomarkers as a Diagnostic Tool

Biomarkers as a Diagnostic Tool By Kasthuri Nair

Ahn, Singh and Tayade discuss the difficulties and delay in diagnosing Endometriosis in their paper titled “Biomarkers in endometriosis: challenges and opportunities.” Thus far research has identified a multitude of potential biomarkers that are found in various parts of the…

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Estrogen Receptor-β in Women’s Health

Estrogen Receptor-β in Women’s Health By Yu Yu

Since the discovery of estrogen receptor (ER), there has been a vast number of studies regarding its functions in cellular and physiological processes. The identification of estrogen receptor-β (ERβ), a second receptor, resulted in a much more complex understanding of the…

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An update of estrogen receptors on human disease

An update of estrogen receptors on human disease By Yu Yu

Estrogens and its receptors influence numerous human physiological processes. Two estrogen receptors exist, including estrogen receptor α (ERα) and ERβ. Hence, it is essential to elucidate the functions of these receptors in healthy and diseased states. This is particularly important…

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New Scoring System to Identify Bowel Endometriosis Syndrome

New Scoring System to Identify Bowel Endometriosis Syndrome By Özge Özkaya

Researchers in Denmark have developed a new scoring system to identify women with bowel endometriosis syndrome (BENS) and monitor the effect of treatments on the syndrome. The scoring system that can be used in everyday clinical practice is the first…

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Endometriosis Does Not Increase Overall Risk of Breast Cancer, Study Finds

Endometriosis Does Not Increase Overall Risk of Breast Cancer, Study Finds By Özge Özkaya

Endometriosis is not associated with the overall risk of breast cancer, according to a study published in the journal Obstetrics & Gynecology.  The condition may, however, be significantly associated with an increased risk of breast tumors that express estrogen receptors (ER)…

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Is there a risk of developing breast cancer for women with endometriosis?

Is there a risk of developing breast cancer for women with endometriosis? By Murat Osman

Understanding the interplay between the development of breast cancer and the presence of endometriosis and vice versa is complex since many risk factors including hormone or genetic variations and medical treatments have a role in each disease process. Thus, parsing…

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Association between blood inflammatory markers and the risk of endometriosis

Association between blood inflammatory markers and the risk of endometriosis By Yu Yu

Previous studies have suggested that aberrant immunologic and inflammatory responses may play a role in the pathogenesis of endometriosis. Peritoneal fluid collected from endometriosis contains elevated immune cells that may enhance the survival of endometriosis by secreting growth factors and…

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Migraine and endometriosis?

Migraine and endometriosis? By Murat Osman

Many studies have alluded to the relationship between endometriosis and migraines but have often been inconclusive. A migraine is a neurologic disorder in which intense pain, either focal or generalized, occurs with or without associated symptoms such as photophobia, nausea,…

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Ultrasound-guided High-intensity Focused Ultrasound can Treat Abdominal Wall Endometriosis

Ultrasound-guided High-intensity Focused Ultrasound can Treat Abdominal Wall Endometriosis By Kasthuri Nair

Endometriosis is a painful and complicated disease that can manifest in various ways. One particular way is Abdominal Wall Endometriosis (AWE), which usually arises from surgery. As is true for other types of endometriosis, there has yet to be a…

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Is operation the best option for infertile patients with digestive endometriosis?

Is operation the best option for infertile patients with digestive endometriosis? By Demet Candaş Green

A severe form of endometriosis affecting 8-12% of women with deep endometriosis is bowel endometriosis. Bowel involvement with associated infertility is a serious challenge for gynecologists who must choose between two main therapeutic options: surgery or medically assisted procreation (e.g.…

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An association of negative coping strategies on the presence of chronic symptoms associated with endometriosis

An association of negative coping strategies on the presence of chronic symptoms associated with endometriosis By Murat Osman

Endometriosis is often a long-term condition that becomes disabling and can affect the quality of life and mental health of many women. One area of endometriosis that needs to be focused on is the psychosocial-related issues of endometriosis and how…

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Swimming Against the Stream: Is Surgery Worthwhile in Women with Deep Infiltrating Endometriosis and Pregnancy Intention?

Swimming Against the Stream: Is Surgery Worthwhile in Women with Deep Infiltrating Endometriosis and Pregnancy Intention? By Murat Osman

Management of Deeply Infiltrating Endometriosis (DIE) is further complicated by the implications of affected patients who plan to become or are pregnant. Optimal management in this situation is not standardized due to a lack of randomized trials comparing primary surgery…

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The Endometriosis Fertility index Could Help Better Predict the Chance of Conceiving After Laparoscopy

The Endometriosis Fertility index Could Help Better Predict the Chance of Conceiving After Laparoscopy By Özge Özkaya

The endometriosis fertility index (EFI) can more reliably predict the chance of a woman getting pregnant following endometriosis surgery compared to the revised-American Society of Reproductive Medicine score, according to a study published in the scientific journal Gynecologic and Obstetric…

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Endometriosis linked with increased risk of cancer and frequency of future surgical procedures

Endometriosis linked with increased risk of cancer and frequency of future surgical procedures By Vishaan Nursey

The purpose of this data research was to determine how women with endometriosis might be predisposed to other medical conditions later on in their lives. In order to determine if endometriosis affected health outcomes, a group of Scottish researchers collected…

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Is there any association between menstrual pain and ovarian cancer?

Is there any association between menstrual pain and ovarian cancer? By Yu Yu

Inflammation may be important in ovarian carcinogenesis. Epidemiological studies show that inflammatory conditions such as endometriosis and pelvic inflammatory disease have been associated with an increased risk of ovarian cancer, while regular use of non-steroidal anti-inflammatory drugs has reduced associated…

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Ovarian Reserve Depletion is not Time Sensitive

Ovarian Reserve Depletion is not Time Sensitive By Kasthuri Nair

The European Journal of Obstetrics & Gynecology and Reproductive Biology recently published a paper titled “Is endometrioma-associated damage to ovarian reserve progressive? Insights from IVF cycles.” This publication by Benaglia et al. examines the controversial relationship between endometriosis and ovarian…

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Urocortin 1 as a noninvasive diagnostic marker for endometriosis

Urocortin 1 as a noninvasive diagnostic marker for endometriosis By Demet Candaş Green

Urocortin 1 (Ucn1) is a neuropeptide secreted by epithelial cells of the endometrium. It promotes endometrial differentiation to help with embryo implantation. Endometriotic lesions were shown to be rich in Ucn1, suggesting a potential role for Ucn1 in the pathogenesis…

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Zinc and lead levels in blood are altered in endometriosis

Zinc and lead levels in blood are altered in endometriosis By Demet Candaş Green

Trace metals are metals usually present in small but measurable amounts in the body. They are needed by living organisms to function properly and when depleted, can be replenished through diet and environmental exposures. Some common trace metals include iron,…

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The role of gene polymorphisms in the pathogenesis of endometriosis

The role of gene polymorphisms in the pathogenesis of endometriosis By Murat Osman

Single nucleotide polymorphisms (SNPs) are the most common type of genetic variations that exist among individuals. These polymorphisms differ by a single nucleotide base pair and are scattered throughout the human genome. Scientists use SNPs as a biological marker to…

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Fetal Membranes Abnormalities in Pregnant Women with DIE

Fetal Membranes Abnormalities in Pregnant Women with DIE By Kasthuri Nair

Marcellin, Méhats, and Gogusev formulated a study where they analyzed alterations in the fetal membranes (FM) of women suffering from severe endometriosis. Their paper titled “Histopathological Alterations in Fetal Membranes of Women With Endometriosis” was recently published in the Reproductive…

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Are there contributing factors to the co-presence of Irritable Bowel Syndrome and Endometriosis?

Are there contributing factors to the co-presence of Irritable Bowel Syndrome and Endometriosis? By Murat Osman

Recently, there has been an association between the presence of endometriosis and increased visceral and pressure hypersensitivity, chronic pelvic pain, and other pain and mood disorders. IBS is a functional bowel disorder that is characterized by recurrent abdominal pain or…

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New Approach could help Preoperative Differentiation of Endometriosis and Cancer

New Approach could help Preoperative Differentiation of Endometriosis and Cancer By Özge Özkaya

Researchers in Japan identified some radiological parameters that could be used to differentiate between endometriosis-associated ovarian cancer (EAOC) and a particular type of benign ovarian endometriosis (OE), making it easier for doctors to offer the right treatment to women who…

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Exposure to organic pollutants and endometriosis

Exposure to organic pollutants and endometriosis By Yu Yu

There is increasing evidence suggesting the associations between exposure to endocrine disrupting chemicals and gynecological diseases over the last decade. In rodent and primate experimental models, consistent associations have been previously found between exposure to dioxins and the onset of…

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With so many imaging tools and modalities, which one should be used for endometriosis?

With so many imaging tools and modalities, which one should be used for endometriosis? By Murat Osman

Intestinal endometriosis affects 5 to 12% of women with endometriosis and commonly presents as dyschezia, rectal bleeding, cyclic defecation pain, constipation, and diarrhea. Currently, surgical treatment includes segmental rectal resection with colorectal anastomosis, but it is often riddled with complications.…

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Symptomatology and Surgical Perspective of Scar Endometriosis

Symptomatology and Surgical Perspective of Scar Endometriosis By Laura Ardighieri

Scar endometriosis is a rare condition that occurs as a consequence of iatrogenic implantation of endometrial tissue following cesarean section, vaginal delivery with episiotomy, laparotomy for hysterectomy, tubectomy, ectopic pregnancy surgeries, appendectomy, hernia repair sites; interestingly it can also occur in…

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Characteristics and location of extrapelvic endometriosis

Characteristics and location of extrapelvic endometriosis By Demet Candaş Green

The authors of this study reviewed the medical records of 1000 women with endometriosis from two geographical areas, New Haven, US and Crete, Greece over a 20-year period with a goal of identifying the presence and location of extrapelvic endometriosis…

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Endometriosis increases the risk of miscarriage

Endometriosis increases the risk of miscarriage By Demet Candaş Green

This systematic review was based on four studies in literature and included a total of 31,167 pregnant women with endometriosis. Several studies were previously performed to establish the association between endometriosis and pregnancy loss with contradictory results. This somewhat large…

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Updates in the Field of Endometriosis: Imaging

Updates in the Field of Endometriosis: Imaging By Kasthuri Nair

Hoyos, Johnson, and Puscheck wrote a chapter titled “Endometriosis and Imaging” that discusses the imagining technologies that can be used to diagnosis and examine individuals with the disease. This chapter evaluates three types of imagining, namely Ultrasound (US), Magnetic Resonance…

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Updates in the Field of Endometriosis: Fertility Preservation

Updates in the Field of Endometriosis: Fertility Preservation By Kasthuri Nair

“Endometriosis and Fertility” is a chapter dedicated to examining the role of endometriosis and endometriomas in decreasing fertility. In other words, the authors of this chapter discuss the relationship between endometriomas, surgeries, and infertility. Barnett, Banks and Decherney also deliberate…

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Comprehensive review on the drug delivery options being used for endometriosis and uterine fibroids.

Comprehensive review on the drug delivery options being used for endometriosis and uterine fibroids. By Murat Osman

Both endometriosis and uterine fibroids (uterine leiomyomas) contribute to infertility, chronic pain, and dysmenorrhea across the world. Thus, drug delivery methods ranging from contraceptives to biochemical systems based on nanotechnology are currently being used and developed. Specifically, long-acting implantable contraceptives…

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Environmental toxins and endometriosis

Environmental toxins and endometriosis By Demet Candaş Green

Polychlorinated biphenyls (PCBs) are organic chlorine contaminants that were widely used in industry due to their excellent physicochemical properties. However, they were banned in the US and the rest of the world in 1979. PCBs are highly stable and resistant…

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Women with endometriosis are increasingly seeking alternative medical therapies for symptom relief

Women with endometriosis are increasingly seeking alternative medical therapies for symptom relief By Murat Osman

Cyclic premenstrual pain and discomfort (CPPD) encompasses a number of symptoms commonly experienced by many women including premenstrual syndrome (PMS) and is experienced by both women with and without endometriosis. CPPD includes physical and emotional symptoms associated with menstruation including…

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Best Time for IVF Between 7 and 25 Months Post Surgery Study Suggests

Best Time for IVF Between 7 and 25 Months Post Surgery Study Suggests By Özge Özkaya

The more severe endometriosis is, the lower the success rate of IVF, according to a new study published in the Journal of Minimally Invasive Gynecology. However, the presence of endometriosis as such does not seem to affect the outcome of…

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Arcyriaflavin A Decreases Endometriosis Cell Viability and Proliferation

Arcyriaflavin A Decreases Endometriosis Cell Viability and Proliferation By Vishaan Nursey

The purpose of this research topic was to determine whether Arcyriaflavin A could serve as a potential new therapeutic option for those suffering from Endometriosis. Arcyriaflavin A is a Cyclin D1 inhibitor. Cyclin D1 regulates the cell cycle by interacting…

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First-line surgery followed by ART versus ART alone among women with colon-involving endometriosis.

First-line surgery followed by ART versus ART alone among women with colon-involving endometriosis. By Murat Osman

Endometriosis, a disease characterized by the presence of endometrial tissue outside the uterus, may cause pelvic and gynecologic complications that affect fertility in women of reproductive age. Several forms of endometriosis have been observed that are characterized by the varying…

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Does endometriosis increase skin cancer risk?

Does endometriosis increase skin cancer risk? By Demet Candaş Green

Two major types of skin cancer are melanoma, which is the least frequent type but with highest metastatic potential; and non-melanoma skin cancers which include basal cell carcinoma and squamous cell carcinoma. Several risk factors are identified for skin cancer…

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Human Endometrium-Derived Mesenchymal Stem Cells for Cell-based Therapies

Human Endometrium-Derived Mesenchymal Stem Cells for Cell-based Therapies By Yu Yu

Mesenchymal stem cells are a promising candidate for cell-based targeted therapies because they have characteristics such as self-renewal, multipotency, low immunogenicity, and non-oncogenicity. It has the capacity to migrate to sites of inflammation including in endometrial lesions and tumor. Most…

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Severe Dyspareunia is Related with "Cul-de-sac" and "Uterosacral Ligament" Endometriosis

 Severe Dyspareunia is Related with By Murat Osman

Endometriosis and especially deep infiltrating endometriosis has been associated with an increased risk of severe dyspareunia. Studies reporting the anatomical sites associated with deep dyspareunia and the severity of pain, and the risk factors of these anatomic sites are incongruent;…

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Endometriosis and Ovarian Cancer Risk

Endometriosis and Ovarian Cancer Risk By Yu Yu

Ovarian cancer prevalence in women with endometriosis is higher than the general population. It is often hypothesized that endometriosis-associated malignancies can occur from ovarian endometrioma. This systematic review by Taniguchi highlighted new insights on the relationship between endometriosis and ovarian…

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Special considerations for the evaluation of Endometriosis on MRI

Special considerations for the evaluation of Endometriosis on MRI By Murat Osman

Pelvic endometriosis may involve either superficial peritoneal or ovarian tissues or may spread to the organs and ligaments of the pelvis in what is known as deeply infiltrating endometriosis (DIE). According to the size and location of these lesions, patients…

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DNA methylation changes in endometrium during the transition from pre-receptive to receptive phase

DNA methylation changes in endometrium during the transition from pre-receptive to receptive phase By Yu Yu

The endometrium is unique in that it undergoes remarkable changes during menstrual cycle under the control of hormones, estrogen, and progesterone. The function of the endometrium is crucial for embryo implantation, during which the endometrium is receptive around a week…

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Women with Deep Infiltrating Endometriosis Have a Higher Risk of Appendix Involvement

Women with Deep Infiltrating Endometriosis Have a Higher Risk of Appendix Involvement By Özge Özkaya

Women with deep-infiltrating endometriosis, a form of endometriosis that invades the abdominal and pelvic cavity, have an increased risk of developing endometriosis of the appendix. It is therefore important to check women with deep infiltrating endometriosis for appendix involvement during…

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Ovarian Endometriomas vs Deep Infiltrating Endometriosis

Ovarian Endometriomas vs Deep Infiltrating Endometriosis By Yu Yu

Ovarian endometrioma (OMA) and deep infiltrating endometriosis (DIE) have been described as two disease entities, although they are both characterized by endometrial tissue located outside the uterus. As OMA and DIE look different histologically, it is puzzling what cause their…

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Glycodelin and altered endometrial function in endometriosis

Glycodelin and altered endometrial function in endometriosis By Yu Yu

A laparoscopic examination is the only diagnostic tool for endometriosis to date. Since the procedure is invasive, there has been much effort by researchers to develop a biomarker for non-invasive diagnosis of endometriosis. To this end, there has been growing…

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The Role of IL-35 in the Pathogenesis of Endometriosis

The Role of IL-35 in the Pathogenesis of Endometriosis By Kasthuri Nair

The molecular mechanism that drives endometriosis remains elusive to this day. Zhang et al believe that interleukin 35 (IL-35) plays a role in the pathogenesis of the disease. Their recent publication in Reproductive Sciences titled “Upregulation of Interleukin 35 in…

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Endometrial Receptivity and Infertility

Endometrial Receptivity and Infertility By Kasthuri Nair

A study entitled “Endometrial receptivity in eutopic endometrium in patients with endometriosis: it is not affected, and let me show you why” was recently published in Fertility and Sterility explored the relationship between endometriosis and infertility. This study conducted by Miravet-Valenciano et al.…

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CA-125 may be useful for the diagnosis of deep infiltrating endometriosis

CA-125 may be useful for the diagnosis of deep infiltrating endometriosis By Asli Bahadirli Talbott

Marco Aurélio Oliveira et al. conducted a prospective study at outpatient gynecology clinic and Endometriosis Treatment Center in Pedro Ernesto University Hospital (Rio de Janeiro State University) between January 2012 and January 2016 with two groups of patients: deep infiltrating endometriosis…

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Reduced vascularization in ovarian endometriomas associated with less pain

Reduced vascularization in ovarian endometriomas associated with less pain By Yu Yu

Angiogenesis, i.e., the development of new blood vessels is believed to play an important role in endometriosis pathogenesis and symptoms. Endometriosis is associated and requires neovascularization to proliferate, invade surrounding normal structure in order to establish an endometriotic lesion. Ovarian…

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Reevaluating response and failure of medical treatment of endometriosis

Reevaluating response and failure of medical treatment of endometriosis By Elisabetta Kuhn

Endometriosis is a chronic disease affecting more than 10% of women in the fertile age and causing "pain" symptoms, that may require medical therapy. Most medical treatments used for endometriosis exert a hormonal mechanism to curtail estrogen effects either locally…

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Bowel Involvement in Deep Infiltrating Endometriosis

Bowel Involvement in Deep Infiltrating Endometriosis By Özge Özkaya

Cleansing the colon before an ultrasound makes it easier to detect rectal nodules of deep infiltrating endometriosis, found a study published in the Journal of Minimally Invasive Gynecology.  Cleansing the colon before a surgery is called bowel preparation and is…

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"Kissing Round Ligaments" May Be a Sign of Bladder Endometriosis

By Özge Özkaya

Specific laparoscopic findings may help surgeons diagnose bladder endometriosis, a rare and often undiagnosed condition.  Bladder endometriosis is thought to affect only around one percent of patients with endometriosis. However, this could be an underestimation and many cases may go…

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Abdominal Wall Endometriosis

Abdominal Wall Endometriosis By Kasthuri Nair

Endometriosis can present itself in many places including within the pelvic organs, the more common manifestation, and outside of the pelvic organs, often referred to as extrapelvic endometriosis. One form of extrapelvic endometriosis is Abdominal Wall Endometriosis (AWE). Yela, Trigo,…

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The Involvement of the Blood Clotting System in Endometriosis

The Involvement of the Blood Clotting System in Endometriosis By Özge Özkaya

The blood clotting system might be over-active in women with endometriosis, found a study published in the scientific journal Reproductive Sciences.  Although the authors stated that there is not enough evidence to suggest that over-coagulation may be directly causing endometriosis…

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Is it Estrogen that Regulates Endometriosis Pain?

Is it Estrogen that Regulates Endometriosis Pain? By Yu Yu

Endometriosis-associated pain is a debilitating condition; however, it is surprising that the perceived pain has no correlation to the endometriosis extent. The mechanism that causes the pain is also poorly understood. Nerve growth factor is enhanced in endometriosis and may increase…

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Dienogest for endometriosis pain in clinical practice

Dienogest for endometriosis pain in clinical practice By Yu Yu

Dienogest is a synthetic progestogen that has been marketed as a medical treatment for endometriosis. Previous randomized controlled clinical trials have shown that it is effective in women with endometriosis at different stages of the disease. Given its recent introduction,…

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Detection of Uterine Malformations and its Link to Endometriosis

Detection of Uterine Malformations and its Link to Endometriosis By Kasthuri Nair

Dr. Abd El Fattah recently published a research article titled “Uterine Cavity Abnormalities in Patients with Endometriosis in Alexandria: A Diagnostic Test Accuracy Study” in Obstetrics and Gynecology International that delineated and presented the results of his study. The study has two…

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Endometriosis and Productivity at Home and in the Workplace

Endometriosis and Productivity at Home and in the Workplace By Kasthuri Nair

Soliman et al. recently published an original paper in the Journal of Managed Care and Specialty Pharmacy that discusses the impact that endometriosis symptoms have on an individual’s productivity level at home and work. This publication is titled “The Effect…

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Hormonal Contraceptives and Endometriomas

Hormonal Contraceptives and Endometriomas By Kasthuri Nair

Hormonal contraceptive has recently become a popular choice of birth control for many women. The European Journal of Obstetrics & Gynecology and Reproductive Biology recently published an article entitled “Incidence of ovarian endometrioma among women with peritoneal endometriosis with and…

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Inhibition of key neurotransmitter could reduce endometriosis-related pain

Inhibition of key neurotransmitter could reduce endometriosis-related pain By Asli Bahadirli Talbott

This study published in the scientific journalMolecular MedicineReports[link] by Lian et al. from Shanghai, China, aims to explore the relationship between transient receptor potential vanilloid type 1 (TRPV1) and endometriosis-associated pain. Pain is the most common symptom for women with…

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Symptoms of Endometriosis May Be Partly Caused by an Infection and Be Treated with Antibiotics

Symptoms of Endometriosis May Be Partly Caused by an Infection and Be Treated with Antibiotics By Özge Özkaya

Women with endometriosis are more frequently diagnosed with chronic endometritis compared to other women found a study published in the medical journal Fertility and Sterility.  According to the authors, this finding suggests that although no causal relationship between these two…

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ICSI Outcomes for Laparoscopic Intervention of Endometriosis

 ICSI Outcomes for Laparoscopic Intervention of Endometriosis By Kasthuri Nair

Women with endometriosis can have trouble conceiving and often turn to fertility treatments for help. Guler et al. recently published a paper in Systems Biology in Reproductive Medicine titled “The Impact of laparoscopic surgery of peritoneal endometriosis and endometrioma on…

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Retinoic Acid Signaling Involved in Endometrial Decidualization

Retinoic Acid Signaling Involved in Endometrial Decidualization By Murat Osman

Decidualization occurs in the eutopic endometrium during the luteal phase and is controlled by signaling pathways such as cyclic adenosine monophosphate (cAMP) and progesterone. Researchers from the Northwestern University School of Medicine reported in their recent paper entitled "Altered Retinoid…

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Cryoablation to Treat Abdominal Wall Endometriosis

Cryoablation to Treat Abdominal Wall Endometriosis By Murat Osman

Endometriosis of the abdominal wall (AWE) is often painful and requires hormone therapy or surgery for clinical management. Thus, non-invasive treatment options to help reduce pain and the progression of these lesions will help patients who suffer from this disease.…

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Immune Response in Endometriosis and Regulatory T cells

Immune Response in Endometriosis and Regulatory T cells By Yu Yu

The adaptive immune system is crucial for many diseases. Lymphocytes, including T cells, are particularly important in the adaptive immune system. Previous research suggested that defective immune response could play a role in endometriosis. The hypothesis proposes that the immune…

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Deep Infiltrating Endometriosis, Surgery and Fertility

 Deep Infiltrating Endometriosis, Surgery and Fertility By Kasthuri Nair

Carneiro, Costa, and Ávila recently published an article in a scientific journal named Reproduction, titled “To operate or not to operate on women with deep infiltrating endometriosis (DIE) before in vitro fertilization (IVF),” that explored the relationship between DIE and infertility.…

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The Unresolved Link Between Sexual Dysfunction and Endometriosis

The Unresolved Link Between Sexual Dysfunction and Endometriosis By Kasthuri Nair

Barbara et al. recently published a systematic review of literature in Reproductive Sciences titled “What Is Known and Unknown About the Association Between Endometriosis and Sexual Functioning” that delves into the effects that endometriosis has on female sexual dysfunction. Endometriosis…

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T-Cell Dysfunction May Worsen Endometriosis

T-Cell Dysfunction May Worsen Endometriosis By Murat Osman

Researchers from the Kyoto Prefectural University of Medicine, Japan, have found that T regulatory lymphocytes (Treg) may be the reason for the formation of the chronic inflammatory environment involved in endometriosis, a study published in The Journal of Clinical Endocrinology &…

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The Endometrium Itself is Genetically Different in Endometriosis Patients

The Endometrium Itself is Genetically Different in Endometriosis Patients By Özge Özkaya

Researchers in China identified a number of genes that are differentially expressed in the eutopic endometrium of women with endometriosis and those without. The researchers think that these genes may be involved in the development of endometriosis and that they…

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Combination Therapy Proves More Efficient in the Treatment of Endometriosis

Combination Therapy Proves More Efficient in the Treatment of Endometriosis By Kasthuri Nair

In their recent paper in British Journal of Pharmacology, entitled “Combination therapy with telmisartan and parecoxib induces regression of endometriotic lesions,” Nenicu et al. illustrate the increased effectiveness of telmisartan used along with a cyclooxygenase-2 (COX-2) inhibitor (a non-steroidal anti-inflammatory…

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Body size, adult height and endometriosis

Body size, adult height and endometriosis By Asli Bahadirli Talbott

Endometriosis is associated with lean body size during childhood, adolescence, and adulthood; tall total adult height; and tall sitting height, found a study published in the scientific journal, Human Reproduction. This study aimed to investigate the relationships between body size across…

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A potential indicator of invasive endometriosis. 

A potential indicator of invasive endometriosis.  By Asli Bahadirli Talbott

Furuya & Masuda et al., in their recent article that will be published in Acta Obstet Gynecol Scand, report that the protein encoded by ZEB1 gene (Zinc finger E-box-Binding homeobox) is a potential indicator of invasive endometriosis.  ZEB1 is a transcription factor that has been implicated…

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Characteristics of endometriosis in adolescents and young girls

Characteristics of endometriosis in adolescents and young girls By Murat Osman

Endometriosis is not an uncommon disease. Even among adolescent girls and young women, endometriosis may cause severe symptoms and lead to complications. Understanding the clinical variability of endometriosis in younger and older patients may lead to insight on the risk…

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How Resveratrol is effective in endometriosis?

How Resveratrol is effective in endometriosis? By Asli Bahadirli Talbott

In their review paper, Mohammadi and Arablou recommend using Resveratrol, a  plant-derived compound, for the treatment of endometriosis. Resveratrol is abundant in nature and can be found in many different plant species, fungi, berries, peanuts, legumes, and grasses; however, grapes…

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Women with endometriosis suffer from anxiety and depression

Women with endometriosis suffer from anxiety and depression By Demet Candaş Green

Endometriosis is considered a disabling condition that may significantly affect social relationships, sexuality and mental health of patients. Women who suffer from endometriosis report high levels of anxiety and depression and other psychological disorders. In this review article, the authors…

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Could the cell surface protein "EWI-2" be the new diagnostic marker for endometriosis?

Could the cell surface protein By Murat Osman

Further Understanding: Researchers from the Reproductive Medicine Center of Wuhan University sought to observe the differential expression of EWI-2, (a cell surface protein and an early activation marker, also known as IGSF8 - Immunoglobulin superfamily member 8) in 145 women…

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Asian Women at Higher Risk of Endometriosis and Less Likely to Conceive with IVF but not Because of their Endometriosis

Asian Women at Higher Risk of Endometriosis and Less Likely to Conceive with IVF but not Because of their Endometriosis By Özge Özkaya

The rate of endometriosis is higher amongst women of Asian origin confirms a study published in the Journal of Assisted Reproduction and Genetics. In addition, pregnancy rates following fertility treatments are lower in this group of women. However, this does…

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Endometriosis as a Barrier to Fertility

Endometriosis as a Barrier to Fertility By Murat Osman

Some of the articles in the from the journal "Acta Obstetricia et Gynecologica Scandinavica (AOGS) issue are discussed in further detail below: Pain caused by endometriosis has been seen to significantly impact women's physical, psychosocial, and sexual health. Although endometriosis has been…

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TFF3 May Be Involved in Endometriosis Research Suggests

TFF3 May Be Involved in Endometriosis Research Suggests By Özge Özkaya

Levels of a protein called TFF3 are significantly increased in the peritoneal cavity (the abdominal space) of women with endometriosis, found a study published in the scientific journal Reproductive Sciences. This increase was in line with levels of other known…

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Can a cure be developed for endometriosis?

Can a cure be developed for endometriosis? By Asli Bahadirli Talbott

The Lancet correspondence highlights that regardless of the importance of endometriosis; its full socioeconomic impact is underestimated and endometriosis research is considerably underfunded. The Endometriosis Priority Setting Partnership (PSP) which includes women with endometriosis, their supporters, health-care practitioners, endometriosis researchers, and representatives from…

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Endometriosis Micrometastasis

Endometriosis Micrometastasis By Yu Yu

Micrometastasis is used to describe the migration of a small number of cancer cells from its original location to the other organs within the body. While endometriosis is not cancer, it occurs when endometrial cells migrate outside of the uterus…

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Endometriosis Reduces Chance of Having a Baby Even with Assisted Reproduction, Study Shows

Endometriosis Reduces Chance of Having a Baby Even with Assisted Reproduction, Study Shows By Özge Özkaya

Endometriosis significantly decreases the likelihood of conceiving even with assisted reproductive technique such as in vitro fertilization (IVF) and Intracytoplasmic sperm injection (ICSI), according to a study published in the European Journal of Obstetrics & Gynecology and Reproductive Biology. In…

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Patient-completed or symptom-based screening tools for endometriosis: a scoping review.

Patient-completed or symptom-based screening tools for endometriosis: a scoping review. By Karime Kalil Machado

Endometriosis affects approximately 10% of women in reproductive age. Its clinical presentation is variable, and symptoms, such as chronic pelvic pain, may overlap with those of other benign conditions, making differential diagnosis challenging. Therefore, a patient-completed screening questionnaire could potentially…

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Scientists Grow Miniature Model of Human Endometrium in the Laboratory

Scientists Grow Miniature Model of Human Endometrium in the Laboratory By Özge Özkaya

Researchers in the U.K. managed to grow a miniature functional model of the human endometrium in the laboratory for the first time. These so-called organoids could help scientists better understands events associated with conditions such as endometriosis and help them…

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How rats can help improve colon endometriosis treatment in humans

How rats can help improve colon endometriosis treatment in humans By Demet Candaş Green

Colorectal endometriosis forms about 3–37% of all deep infiltrating endometriosis (DIE) cases. DIE is a highly invasive type of endometriosis, occurs when ovarian endometriomas overgrow and rupture, releasing their contents into the abdominal and pelvic cavity, resulting in the formation…

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More than Four Years Pass Before Endometriosis is Diagnosed After Symptoms First Appear

More than Four Years Pass Before Endometriosis is Diagnosed After Symptoms First Appear By Özge Özkaya

The average time that passes between the onset of symptoms such as pelvic pain and the diagnosis of endometriosis is 4.4 years on average, according to a study conducted by researchers at the pharmaceutical company Abbvie and published in the…

Lay Summary

Women with Endometriosis Undergoing Surgery Often Require Further Treatment

Women with Endometriosis Undergoing Surgery Often Require Further Treatment By Ezio Rosato

Recurrence of endometriosis is common even in women who underwent surgery, a new study confirmed. This suggests that women with endometriosis should be closely followed up even after treatment with surgery. For the study published online in the Journal of…

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Unexpected "cancer-related" mutations in "non-cancerous" endometriosis: Do they predict aggressiveness?

Unexpected By Laura Ardighieri

A study supported by Endometriosis Foundation of America, reported by scientists from Johns Hopkins Medicine (Baltimore, USA) and the University of British Columbia (Vancouver, Canada) have identified the molecular alterations of deep infiltrating endometriosis trough a wide exome­ sequencing (protein-coding genetic alphabet…

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Hypoxia induces molecular pathways favoring survival of endometriosis

Hypoxia induces molecular pathways favoring survival of endometriosis By Laura Ardighieri

Kuei-Yang Hsiao and colleagues from the Department of Physiology and the Department of Obstetrics and Gynecology College of Medicine, National Cheng Kung University, Tainan, Taiwan, have investigated the molecular basis of this phenomenon. In particular, they found that hypoxia significantly…

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Ultrasound Ablation to Treat Endometriosis

Ultrasound Ablation to Treat Endometriosis By Murat Osman

Further Understanding: Deeply infiltrating endometriosis (DIE) often presents in the rectosigmoid colon in women with endometriosis and can be the major cause of gastrointestinal and pelvic symptoms. This preliminary study focuses on the utility of High-Intensity Focused Ultrasound (HIFU) in…

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New Molecular Targets for the Treatment of Endometriosis-Associated Pain

New Molecular Targets for the Treatment of Endometriosis-Associated Pain By Ezio Rosato

The study identifies potential new targets for alleviating chronic pelvic pain that afflicts many women with endometriosis. A new study published in the scientific journal Redox Biology shows that molecules called microRNAs could be a potential new target to combat…

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Women with Endometriosis May Require Additional Care During Pregnancy and Labour

Women with Endometriosis May Require Additional Care During Pregnancy and Labour By Özge Özkaya

Women with endometriosis have a higher risk of bleeding after giving birth, found a study published in the Chinese Medical Journal. In addition, women with endometriosis who conceived by assisted reproduction may also have a higher risk of bleeding after…

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Immune substances in peritoneal fluid for endometriosis diagnosis and armamentarium

Immune substances in peritoneal fluid for endometriosis diagnosis and armamentarium By Yu Yu

Cytokines are immune substances secreted by a broad range of cells within the body, including immune cells like the macrophages, B lymphocytes, T lymphocytes, mast cells, and non-immune cells such as the endothelial cells and fibroblasts. They are important in…

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Characteristics of Ovarian Endometriotic Cysts Could Help Determine Whether Endometrioma Will Reoccur

Characteristics of Ovarian Endometriotic Cysts Could Help Determine Whether Endometrioma Will Reoccur By Özge Özkaya

The features of ovarian endometriotic cysts could help predict whether endometrioma will re-occur in individual patients, according to a study published in the European Journal of Obstetrics and Gynecology. Predicting the risk of recurrence is important because it can help…

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Metabolomic profiling and biochemical evaluation of the follicular fluid of endometriosis patients.

Metabolomic profiling and biochemical evaluation of the follicular fluid of endometriosis patients. By Yu Yu

Metabolites are the intermediates and products of metabolism from our body. Increasingly the study of metabolite content in biological systems can be used to derive useful information to identify disease-related markers, such as the use of glucose in the blood…

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Genetic Variations May Link Risk of Endometriosis and Ovarian Cancer

Genetic Variations May Link Risk of Endometriosis and Ovarian Cancer By Özge Özkaya

Variations in a gene called HNF1B could be linked to the risk of endometriosis, according to a study published in the medical journal Gynecologic Oncology. Previous studies had identified the same genetic variation as a risk factor for ovarian cancer.…

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Complexity of Urinary Tract Endometriosis: Highlights from a Review

Complexity of Urinary Tract Endometriosis: Highlights from a Review By Murat Osman

Understanding the Clinical Complexity of Urinary Tract Endometriosis: Highlights from a Review While endometriosis predominantly affects the pelvic reproductive organs, spread to the urinary tract has also been observed and requires a different subset of surgical techniques for treatment. Accurate…

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Endometriosis doubles the risk of sexual dysfunction

Endometriosis doubles the risk of sexual dysfunction By Karime Kalil Machado

Women with endometriosis are more than two times as likely to present sexual dysfunction as compared to women without the disease, according to a study published in Gynecologic Endocrinology. In this study conducted by researchers from the University of São…

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Diet & Endometriosis

Diet & Endometriosis By Asli Bahadirli Talbott

Diet and the risk of developing endometriosis Current studies examining the modifiable risk factors for prevention of endometriosis are pointing to the development of effective dietary restrictions. Thus understanding the role of nutrition in endometriosis has become critical. In a…

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Laparoscopic Hysterectomy as Effective as Total Abdominal Hysterectomy, Study Suggests

Laparoscopic Hysterectomy as Effective as Total Abdominal Hysterectomy, Study Suggests By Ezio Rosato

Laparoscopic hysterectomy, a minimally invasive surgical procedure that is used to remove the uterus, results in similar rates of disease-free survival among women with stage 1 endometrial cancer as the standard abdominal hysterectomy, showed a study published in The Journal…

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Women with Endometriosis Should be Closely Monitored During Pregnancy and Birth, Study Suggests

Women with Endometriosis Should be Closely Monitored During Pregnancy and Birth, Study Suggests By Özge Özkaya

Women with endometriosis have a significantly higher risk of developing several complications during pregnancy and delivery such as preeclampsia and placental complications, according to a study by Danish researchers. In addition, babies born to mothers with endometriosis have a higher…

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Endometriosis Can Reduce Sleep Quality and Negatively Impact Patient’s Quality of Life Study Suggests

Endometriosis Can Reduce Sleep Quality and Negatively Impact Patient’s Quality of Life  Study Suggests By Özge Özkaya

Most women with endometriosis of the posterior cul-de-sac, experience poor sleep quality, excessive daytime sleepiness and insomnia, according to a study published in the European Journal of Obstetrics & Gynecology and Reproductive Biology. Poor sleep quality can reduce the quality…

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