Nasuhi Engin Aydin, MD

Nasuhi Engin Aydin,  M.D. a graduate of Hacettepe University Faculty of Medicine, Ankara with E.C.F.M.G. Certification. He started his academic career at Ankara University working on short-term carcinogenicity tests with his research cited in NCI, Bethesda Monograph 65. He has been working as a registered Anatomic Pathologist in Turkey since 1983. Main topics of interest are research on gynecologic pathology besides forensic and surgical pathology with manuscripts published internationally. 

Current research on adenomyosis tissues with immunohistochemistry reveal novel findings

Dr. Xiaofang Xu and associates from Fudan University, China have recently published their research on adenomyosis-related research results in "Reproductive Biology and Endocrinology". Adenomyosis is a benign gynecological condition, prevalent worldwide that is characterized by the presence of ectopic endometrial tissues in the myometrium. Dysmenorrhea is the most common symptom besides abnormal uterine bleeding. Scientific findings indicate that adenomyotic lesions, similar to endometriotic lesions, are wounds undergoing repeated tissue injury and repair (ReTIAR) due to cyclic bleeding of ectopic endometria.  In this setting,…

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Endometrial receptivity after the removal of ovarian endometriotic cysts

Mikhaleva and associates from the "Russian Research Institute of Human Morphology" published their results in “Reproductive Sciences” yielding their novel morphological findings of eutopic endometria in patients following surgical excision of endometriotic ovarian cysts. Current therapeutic measures are targeting to relieve symptoms related to endometriosis as a fundamental goal. There is a need for further scientific elucidation of endometriosis-related patho-morphology. Infertility is an important aspect of endometriosis that seems to be mainly due to subtle changes in endometrial capacity for…

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Oxygen deprivation (hypoxia) has a critical role in the pathogenesis and progression of endometriosis

Dr. Wan-Ning Li and associates from academic institutions from Taiwan have published their review paper on the role of hypoxia and possible therapeutic outcomes in the medical journal named "Reproduction" recently.  Endometriosis is an important ailment with huge medical and social impact that remains elusive in regard to its pathogenesis. The development of endometriosis seems to be related to the interactions of multiple gene–gene and gene–microenvironmental factors. Hypoxia-inducible factors (HIFs), a group of heterodimeric molecules with α and β subunits, are…

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A comparison of symptomatology and histopathologic features in surgically resected colorectal endometriosis

Dr. Tschan and associates from Feldrich Academic Teaching Hospital, Austria published their retrospective research on patients requiring colorectal surgical resection for endometriosis in European Journal of Medical Research. Bowel endometriosis requiring colorectal surgical resection causes important morbidity. The rectum and sigmoid colon are the most frequent involvement around 90% of intestinal endometriosis cases. Most of the patients experience diminished quality of life due to pain, infertility, and repeated operations besides possible long-term medical therapy. The histopathological features of endometriosis lesions…

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"Speckle sign": a novel transvaginal ultrasound finding for posterior compartment endometriosis

Dr. Balcacer and associates from three medical institutions located in the USA report the results of their retrospective study on deep infiltrating endometriosis utilizing transvaginal ultrasound examination and the proposed  “speckle sign” in the "Journal of Ultrasound Medicine". Pelvic ultrasound is routinely used mainly for the diagnostic workup of endometriosis but deep infiltrating endometriosis may cause diagnostic challenges due to common atypical presentations. This study focused on defining a meaningful sign in patients with deep invasive endometriosis where the authors…

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Time for noninvasive serum markers for endometriosis diagnosis

Dr. Onur Guralp and associates from Germany and Turkey published their results on serum markers predicting endometriosis in the "Journal of Obstetrics and Gynaecology".   Still, in 21st-century medicine, doctors can not diagnose endometriosis using biochemical serum markers. Proposed serum markers suggested for this purpose such as CA125 and others have been so far not effective in this regard. In this study researchers aimed to find the diagnostic value of a panel consisting of CA125, endocan, YKL-40, and copeptin for the…

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Separation of epithelia and stroma components in endometriosis lesions yields remarkable molecular points - Ie-Ming Shih, MD, Ph.D.

The pathologies of adenomyosis and endometriosis are unique among non-malignant gynecological diseases and provide fertile research topics. Ectopic endometrial tissues may have distinct molecular changes distinct from eutopic endometria despite having similar morphology. In this regard, there are intriguing suggestions as peritoneal endometriosis and adenomyosis seem to be molecularly related. Research made on molecular aspects of eutopic and ectopic endometrium by separating epithelia from stroma has been rewarding. Whole-exome sequencing besides global methylation profiles utilizing this separation technique by laser-capture microdissection was…

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It is time for redefining endometriosis with our contemporary scientific knowledge - Philippe Koninckx, MD, Ph.D.

Endometriosis defined as endometrium-like tissue outside the uterus has a poorly understood natural history. It is a heterogeneous disease having genetic-epigenetic features with many biochemical changes in the lesions. The Sampson hypothesis of implanted endometrial cells following retrograde menstruation is not able to explain all observations. The property of genetic- and epigenetic features transmitted at birth may explain the hereditary aspects, the predisposition, and the endometriosis-associated changes in the endometrium, immunology, and placentation. However, the pathogenesis of cystic ovarian or deep…

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How to unveil the discrepancy regarding the effect of chemicals on the etiology of endometriosis

Kristen Upson from Michigan State University published a review article evaluating research papers on environmental factors effective in endometriosis from an epidemiological perspective in "Current Epidemiology Reports". Endometriosis is a multifactorial disease with anatomical, hormonal, immunological, estrogenic, genetic, epigenetic, and environmental factors operating. Exogenous chemicals, interfering with any aspect of the hormonal milieu (endocrine-disrupting chemicals) are suspected in yielding a risk in endometriosis. The list of environmental chemicals suspected having a role in endometriosis expanded tremendously and includes perfluoroalkyl substances,…

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Endometriosis and adenomyosis could be the “sides of the same coin”.

The two common gynecological disorders, namely adenomyosis, and endometriosis are not settled yet, whether they are representing two different entities or different phenotypes of the same ailment. Dr. Maruyama and colleagues from Nara, Japan searched PubMed and Google Scholar electronic databases published between January 2000 and April 2020 for keywords ‘adenomyosis’, ‘endometriosis’, ‘pathogenesis’, ‘classification’, ‘subtype’, ‘phenotype’, and ‘fibrosis’. The results of this search were published in the "European Journal of Obstetrics & Gynecology and Reproductive Biology" recently. Endometriosis has three…

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It is time for non-invasive tests for peritoneal endometriosis diagnosis

Maria Szubert with colleagues from Lodz Medical University, Poland, investigated the possibility of potential diagnostic biomarkers in the eutopic endometrial tissue from peritoneal endometriosis patients and published their results in the "Journal of Gynecology Obstetrics and Human Reproduction". Currently, diagnostic laparoscopy is the golden standard procedure to prove peritoneal endometriosis since it is not visible either on ultrasound or MRI. There is a need to have a contemporary non- or less-invasive diagnostic tool for patients with a presumptive diagnosis of…

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An animal model of endometriosis reveals stress related disturbed vitamin D - vitamin D receptor axis

Lopez and colleagues from academic institutions of Puerto Rico published their experimental endometriosis findings on female rats regarding the effect of stress on vitamin D-vitamin D receptor systems and recently published their findings in "Reproductive Sciences". The group previously showed the negative impact of stress in the same animal model of endometriosis.  Altered levels of vitamin D are noted in patients with endometriosis. Vitamin D signaling through the vitamin D receptor system is known to have anti-proliferative properties. Stress may alter adversely…

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Time for reassessment : Laparoscopic surgery and bowel endometriosis

Ferrero and associates from medical centers of Verona and Genoa, Italy, made a comprehensive review covering all aspects of the surgical approach to bowel endometriosis, published their results in "Best Practice & Research Clinical Obstetrics and Gynaecology". Bowel endometriosis is the presence of endometriotic glands and stroma infiltrating at least the main muscle layer of the intestinal wall and causing symptoms like dyschezia, abdominal bloating, constipation, or diarrhea worsening during the menstrual cycle, the passage of mucus in the stools, rectal…

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Endometrial polyps of patients with and without endometriosis

Endometrial polyps are benign local overgrowths comprising both glands and the stroma, and are quite common in gynecological practice. Endometriosis patients also commonly have polyps, which have yielded different features than those from patients without endometriosis.  Dr. Jiangand and associates from the Center of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical University, China, have made recent research on polyps from endometriosis patients comparing with those from non-endometriosis. The results have been published in a recent issue of  "The…

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Natural history of spontaneous endometriosis in crab-eating monkeys

Kaori Hayashi and associates from Shiga University of Medical Science, Japan, published their observations on spontaneously occurring endometriosis in crab-eating monkeys in "Tohoku Journal of Experimental Medicine"https://www.jstage.jst.go.jp/article/tjem/251/4/251_241/_pdf/-char/en. The presence of endometrial tissue outside the uterus, i.e., endometriosis is a progressive prevalent condition among women of reproductive age. Along with abdominal pain and infertility endometriosis severely affects the quality of life in young women. Animal models of human disease are quite valuable in medical research in revealing pathogenetic mechanisms and investigating the effects…

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The effects of nutrients on endometriosis-related symptoms

A recent literature review from the Netherlands by researchers Emma Huijs and Annamiek Nap, published in "Reproductive Biomedicine Online" puts light on the effects of some nutrients for endometriosis-related symptomatology.  Endometriosis has heterogeneous pathogenesis involving genetic, immunological, environmental, and hormonal components. Due to this complexity, current treatment methods are not completely successful, and women with endometriosis are trying to control their diseases individually. These women are in the search for remedies available in daily life. An Australian online survey showed…

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Suggested remedies for endometriosis patients during coronavirus pandemic

The pandemic of COVID-19 continues to have important effects on endometriosis patients worldwide. Many health care facilities stopped providing surgical management and outpatient appointments are canceled or postponed. Dr. Leonardi from Australia and associates from several countries published their proposals for this awkward situation in their recent paper at the open-access journal, "Human Reproduction". The authors proposed expert opinion-based self-management guidance for endometriosis patients in particular which may be applicable to others during crisis periods.  Unavailable surgeries postponed appointments to healthcare…

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International experts commentary for assisted fertility treatment facilities amidst COVID-19

A multinational and multi-institutional commentary led by Dr. Alviggi from Italy and Dr.Esteves from Brazil has addressed important issues on assisted reproductive technology treatment amid COVID-19 lockdown suggesting remedies in the journal of "Reproductive Biology and Endocrinology" May 2020 issue. Prolongation of lockdown in health services providing high tech fertility treatments has been advocated by most of the authorities, however, this situation is affecting adversely both the infertility patients and the whole society together. Restarting these services after the lockdown…

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Discrepancies between racial/ethnic groups and choice of hysterectomy procedures

Dr. Pollack and associates from Washington University, St.Louis, made multistate research regarding the patient profile in hysterectomies and published their results in the 2019 December issue of "The Journal of Minimally Invasive Gynecology". The most frequently performed nonobstetric surgery in women is hysterectomy, with more than 400 000 procedures for benign gynecologic conditions performed each year in the US. Minimally invasive surgery, i.e. vaginal, laparoscopic/robot-assisted hysterectomy is preferred over abdominal hysterectomy for benign conditions owing to a quick return to…

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Laparoscopic surgery for COVID-19 positive patients: A Dilemma

COVID-19 pandemic is the most important issue of our days. In this regard, it is crucial to keep health care providers (HCPs) safe and away from contamination. Doctors Without Borders reported that regardless of all preventive measurements, nearly eight percent of the total COVID-19 cases in Italy are HCPs making HCP the highest risk group, and the importance of protecting this group is clear. All HCP who are in direct contact with infectious secretions from a patient with COVID-19 at…

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