Nasuhi Engin Aydin, MD

Nasuhi Engin Aydin,  M.D. a graduate of Hacettepe University Faculty of Medicine, Turkey received Philadelphia based E.C.F.M.G. Certification. He started his academic career at Ankara University working on short-term carcinogenicity tests with his research cited in NCI, Bethesda Monograph 65. He has been working as a registered Anatomic Pathologist in Turkey since 1983. Main topics of interest are research on gynecologic pathology besides forensic and surgical pathology with manuscripts published internationally. 

An animal model of endometriosis reveals stress related disturbed vitamin D - vitamin D receptor axis

Lopez and colleagues from academic institutions of Puerto Rico published their experimental endometriosis findings on female rats regarding the effect of stress on vitamin D-vitamin D receptor systems and recently published their findings in "Reproductive Sciences". The group previously showed the negative impact of stress in the same animal model of endometriosis.  Altered levels of vitamin D are noted in patients with endometriosis. Vitamin D signaling through the vitamin D receptor system is known to have anti-proliferative properties. Stress may alter adversely…

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Time for reassessment : Laparoscopic surgery and bowel endometriosis

Ferrero and associates from medical centers of Verona and Genoa, Italy, made a comprehensive review covering all aspects of the surgical approach to bowel endometriosis, published their results in "Best Practice & Research Clinical Obstetrics and Gynaecology". Bowel endometriosis is the presence of endometriotic glands and stroma infiltrating at least the main muscle layer of the intestinal wall and causing symptoms like dyschezia, abdominal bloating, constipation, or diarrhea worsening during the menstrual cycle, the passage of mucus in the stools, rectal…

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Endometrial polyps of patients with and without endometriosis

Endometrial polyps are benign local overgrowths comprising both glands and the stroma, and are quite common in gynecological practice. Endometriosis patients also commonly have polyps, which have yielded different features than those from patients without endometriosis.  Dr. Jiangand and associates from the Center of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical University, China, have made recent research on polyps from endometriosis patients comparing with those from non-endometriosis. The results have been published in a recent issue of  "The…

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Natural history of spontaneous endometriosis in crab-eating monkeys

Kaori Hayashi and associates from Shiga University of Medical Science, Japan, published their observations on spontaneously occurring endometriosis in crab-eating monkeys in "Tohoku Journal of Experimental Medicine"https://www.jstage.jst.go.jp/article/tjem/251/4/251_241/_pdf/-char/en. The presence of endometrial tissue outside the uterus, i.e., endometriosis is a progressive prevalent condition among women of reproductive age. Along with abdominal pain and infertility endometriosis severely affects the quality of life in young women. Animal models of human disease are quite valuable in medical research in revealing pathogenetic mechanisms and investigating the effects…

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The effects of nutrients on endometriosis-related symptoms

A recent literature review from the Netherlands by researchers Emma Huijs and Annamiek Nap, published in "Reproductive Biomedicine Online" puts light on the effects of some nutrients for endometriosis-related symptomatology.  Endometriosis has heterogeneous pathogenesis involving genetic, immunological, environmental, and hormonal components. Due to this complexity, current treatment methods are not completely successful, and women with endometriosis are trying to control their diseases individually. These women are in the search for remedies available in daily life. An Australian online survey showed…

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Suggested remedies for endometriosis patients during coronavirus pandemic

The pandemic of COVID-19 continues to have important effects on endometriosis patients worldwide. Many health care facilities stopped providing surgical management and outpatient appointments are canceled or postponed. Dr. Leonardi from Australia and associates from several countries published their proposals for this awkward situation in their recent paper at the open-access journal, "Human Reproduction". The authors proposed expert opinion-based self-management guidance for endometriosis patients in particular which may be applicable to others during crisis periods.  Unavailable surgeries postponed appointments to healthcare…

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International experts commentary for assisted fertility treatment facilities amidst COVID-19

A multinational and multi-institutional commentary led by Dr. Alviggi from Italy and Dr.Esteves from Brazil has addressed important issues on assisted reproductive technology treatment amid COVID-19 lockdown suggesting remedies in the journal of "Reproductive Biology and Endocrinology" May 2020 issue. Prolongation of lockdown in health services providing high tech fertility treatments has been advocated by most of the authorities, however, this situation is affecting adversely both the infertility patients and the whole society together. Restarting these services after the lockdown…

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Discrepancies between racial/ethnic groups and choice of hysterectomy procedures

Dr. Pollack and associates from Washington University, St.Louis, made multistate research regarding the patient profile in hysterectomies and published their results in the 2019 December issue of "The Journal of Minimally Invasive Gynecology". The most frequently performed nonobstetric surgery in women is hysterectomy, with more than 400 000 procedures for benign gynecologic conditions performed each year in the US. Minimally invasive surgery, i.e. vaginal, laparoscopic/robot-assisted hysterectomy is preferred over abdominal hysterectomy for benign conditions owing to a quick return to…

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Laparoscopic surgery for COVID-19 positive patients: A Dilemma

COVID-19 pandemic is the most important issue of our days. In this regard, it is crucial to keep health care providers (HCPs) safe and away from contamination. Doctors Without Borders reported that regardless of all preventive measurements, nearly eight percent of the total COVID-19 cases in Italy are HCPs making HCP the highest risk group, and the importance of protecting this group is clear. All HCP who are in direct contact with infectious secretions from a patient with COVID-19 at…

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Defective “ferroptosis”: a new pathogenetic explanation of endometriosis

Dr. Ng and associates from Tufts University School of Medicine, Boston, USA made a comprehensive review of the role of the iron element in the development of endometriotic lesions. Though iron element is essential for cell survival, and its deficiency is important in reproductive disorders, iron excess is equally harmful.  In endometriosis, eutopic endometrium has resistance to the process of iron-mediated programmed cell death, i.e., ferroptosis. As far as eutopic endometrial cells do not undergo programmed cell death by ferroptosis, the cells…

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Non-hormonal chemicals for endometriosis related pain reduction

Loi and colleagues conducted a clinical prospective study at the Department of Obstetrics and Gynecology, University of Cagliari, Italy, and published in the journal "International Journal of Women’s Health".  Formation of adhesions and/or interference with the reproductive process endometriosis, severe chronic pain results and may cause functional disability requiring treatment. Activated mast cells in these lesions especially in deep infiltrating lesions being proximal to nerves, may contribute to pain by a direct effect on nerve structures. Cytokines and growth factors secreted…

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All aspects of endometriosis reviewed with focus on modern management

Dr. Chapron and associates from academic centers in France published in Nature Review Endocrinology, a comprehensive review on endometriosis. The article is inclusive of all aspects of endometriosis but especially focuses on the management of the disease with its contemporary status.  Having a heterogeneous nature, endometriosis has a well- recognized subgroups namely, superficial peritoneal lesions, ovarian endometriomas, and deep infiltrating endometriosis. Additionally, endometriosis may be seen in extragenital locations, e.g. pleural, diaphragmatic or umbilical. Adenomyosis is a condition characterized by infiltrating endometrial tissue into…

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Leiomyomas have similar genetic background with endometriosis

This multicenter research conducted in institutions located in the USA and UK published in Nature Communications, October 2019 issue.  Leiomyomata of the uterus are hormone-dependent tumors with an estimated prevalence of about  20-77%. İn several publications. Research in uterine leiomyoma pathogenesis suggests overlapping genetic similarities with endometriosis, both of them affecting millions of women worldwide causing considerable morbidity.  Revealing similar pathogenic mechanisms for uterine leiomyomas and endometriosis may not only a result in deeper better understanding of the pathogenesis, but…

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Primary care physicians have a crucial role in the early diagnosis of endometriosis

Dr. Verket and associates from the University of Oslo, Norway, published their cross-sectional anonymous postal questionnaire study in "BMJ open". Diagnosing endometriosis is difficult because dysmenorrhea, dyspareunia, and infertility are also common among other diseases. The most accurate and reliable diagnosis of endometriosis is by confirmation of the histopathologic findings through surgically resected biopsies. Screening tool development in endometriosis has been confined to women in secondary and tertiary gynecological surgical units or infertility clinics that have sophisticated health facilities.  A prediction model…

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An important environmental contaminant dioxin has links to the pathogenesis of endometriosis

Giampaolinoa and associates from the University of Genoa, Italy published a review on environmental contaminant dioxin and its possible epigenetic role related to endometriosis development in "Gynecological Endocrinology". The authors made a narrative review, with the results of their search questions: “Does it really exist a relation between Dioxin and Endometriosis? Could it be explained through an epigenetic approach?”. The search string was applied to the electronic literature databases MEDLINE and WEB of SCIENCE.  There is increasing evidence of serious…

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Does T-cadherin have a role in endometriosis?

Qinsheng Lu and associates from Guangzhou Medical University, China made a unique study of T-cadherin expression in endometriosis and published their results in the journal "Human Reproduction".  Endometriosis is a common condition of reproductive age women, where hormones, immunity, environment and genetic/epigenetic gene alterations play a role in the pathogenesis. Though endometriosis is not a malignant disease endometriotic tissues have many cancer-like features, such as cell invasion, migration, proliferation, and anti-apoptosis. T-cadherin expression is reduced in various types of cancers,…

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What we should know in managing infertility related to endometriosis?

Dr. Llarena and associates made a comprehensive review of the causes of infertility in endometriosis and adverse effects of surgical procedures in Clinical Medicine Insights: Reproductive Health. Infertility is an important issue in endometriosis patients and about 30-50 % face infertility. Both the pathogenesis of endometriosis and its surgical treatment contribute to decreased ovarian reserve in this regard. There are multiple mechanisms contributing to infertility in endometriosis patients both being related to its etiopathogenesis and extrinsic causes related to surgery. Distorted…

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A comprehensive review on the etiopathogenesis of endometriosis

Endometriosis, being a heterogeneous disease has a highly complex etiopathogenesis.  A multicenter comprehensive review on this important subject from Italy, Germany, and the USA by Lagana and associates, was recently published in the "International Journal of Molecular Sciences" an open-access journal. Computerized databases were used to retrieve publications using the Medical Subject Headings (MeSH)  “Endometriosis”  with “Etiology”, “Immunology”  “Genetics”  and “Epigenesis, Genetic”.  Available scientific evidence reveals that endometriosis is not just simply a transplanted normal endometrium. Numerous differences in hormone receptor levels,…

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A new ultrasound subgrouping reveals good clinical correlations in adenomyosis

Exacoustos and colleagues from two endometriosis tertiary referral centers in Rome, Italy published their observational, prospective study of the recently proposed transvaginal ultrasonographic scoring system in the "Journal of Minimally Invasive Gynecology". Adenomyosis or “endometriosis interna” is defined as the presence of endometrial glands and stroma within the myometrium along with the hypertrophy of the muscle tissue. This condition is also be associated with pelvic endometriosis and both conditions share similar pathogenesis and symptoms. The ultrasonographic scoring systems are designed to…

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Medical databases yield 32 published cases of surgically treated liver endometriosis

Prodromidou and colleagues from Greece have published a review of surgically diagnosed, histopathologically proven liver endometriosis cases published worldwide, in the journal "Annals of Hepatology". Searching at three electronic medical databases namely, PubMed (1966–2019), Scopus(2004–2019), and Google Scholar (2004–2019) for observational studies and case reports, there were  27 studies which yielded 32 patients with surgically treated liver endometriosis. Histopathological examination of surgical specimens revealed the presence of endometrial stroma and glands. In cases in which immunochemistry was performed, estrogen and…

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