Nasuhi Engin Aydin, MD
Nasuhi Engin Aydin, MD is a graduate of Hacettepe University Faculty of Medicine, Ankara with ECFMG Certification. He started his academic career at Ankara University working on short-term carcinogenicity tests, supported by TUBITAK grant with his research cited in NCI, Bethesda Monograph 65. He has been working as a licensed Anatomic Pathologist in Turkey since 1983. Main topics of interest are anatomic and surgical pathology with published manuscripts mainly in gynecopath and forensics.(Web of Science ResearcherID O-90432016 H-Index 20 as of 12/2022)
https://www.youtube.com/watch?v=cNq6VTWVk80
The Endometrium Speaks: Inflammatory Clues to Peritoneal Endometriosis
A prospective study conducted in Krakow, Poland, and recently published in BMC Women’s Health, explored the potential link between pelvic peritoneal endometriosis and chronic endometritis—a persistent inflammation of the uterine lining that may affect fertility. As endometriosis is a chronic, inflammatory condition, the researchers proposed that chronic endometritis could be a common and under-recognized co-existing condition, potentially contributing to reduced endometrial receptivity and poorer reproductive outcomes. In this study, 64 women undergoing laparoscopy for suspected endometriosis (due to pelvic pain…
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Which Comes First: Endometriosis or Depression?
A short communication in the format of letter to the editor, recently published in the Archives of Gynecology and Obstetrics highlights the potential immunological link between endometriosis and depression. Endometriosis is a highly prevalent gynecological disorder characterized by chronic inflammation and immune dysregulation, particularly in response to ectopic endometrial tissue. Depression, a common and debilitating comorbidity in women with endometriosis, is similarly associated with immune dysfunction and chronic systemic inflammation. Emerging evidence suggests a shared immunopathogenic basis between the two…
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Could sexual activity during menses be a risk factor in endometriosis?
Italian researchers recently published a literature review in Women’s Health exploring the potential role of endometriosis and menstrual sexual activity. The retrograde menstruation theory, first proposed in the early 20th century, remains a popular hypothesis suggesting that menstrual debris contribute to the development of endometriosis in the peritoneal cavity. It is proposed that uterine contractions during sexual intercourse, with or without orgasm, could enhance the retrograde flow of endometrial debris through the uterine tubes. A research team led by Dr.Vercellini conducted an…
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Prevalence of congenital uterine abnormalities and endometriosis
A Swiss research group from Schaffhausen and Zurich conducted a retrospective prevalance study of congenital uterine anomalies among endometriosis patients. The final manuscript has appeared in a recent issue of the medical journal JMIG. Endometriosis being an estrogen-dependent inflammatory disorder affects millions of women worldwide. The most popular pathogenetic theory of “retrograde mensturation” raises a question on the importance of obstructive congenital uterine abnormalities among this gynecologic patient group. A group of researchers from Switzerland have recently published a retrospective…
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Unique features of endometrial cells in endometriosis
Researchers from the University of Texas, San Antonio, have published a detailed study on the properties of endometrial cell components in relation to endometriosis, entitled "Hypersensitive intercellular responses of endometrial stromal cells drive invasion in endometriosis", in the scientific journal eLife. The widely accepted theory of endometriosis suggests that during menstruation, endometrial cells enter the peritoneal cavity, leading to implantation and invasion similar to metastasis. However, limited research has focused on the cellular features of endometrial components that could facilitate this process.…
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Gut Microbiota and Endometriosis; new kid on the block!
Dr. Anjeza Xholli and colleagues from the University of Genova, Italy, conducted a comprehensive review on the potential impact of gut microbiota on gastrointestinal symptoms in endometriosis patients, publishing their findings in Pharmaceuticals, in the leadership of Dr.Cagnacci. Approximately 90% of endometriosis patients experience gastrointestinal symptoms, including bloating, nausea, constipation, diarrhea, and vomiting. Recent research has highlighted a connection between gut microbiota and female reproductive health, suggesting that microbial imbalances may contribute to disease progression. The authors performed a systematic literature…
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Adenomyosis : Early Diagnosis is Essential in Adolescence
Dr. Martire and colleagues from Siena University, Italy, published their recent research on adenomyosis in adolescents in the journal Diagnostics. Traditionally considered a condition affecting women over 40, adenomyosis is now recognized as a disease with early onset, including during adolescence, thanks to advancements in ultrasound and MRI. The authors conducted a comprehensive review of English-language studies in the MEDLINE database through April 2024, focusing on adenomyosis in adolescence. They concluded that early diagnosis is essential to mitigate severe symptoms,…
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Comparison of Postoperative Complications in Total vs. Supracervical Laparoscopic Hysterectomy for Endometriosis
Dr. Raanan Meyer and his team from Cedars-Sinai Medical Center, Los Angeles, have published a study in Archives of Gynecology and Obstetrics, comparing the outcomes of total laparoscopic hysterectomy (TLH) and laparoscopic supracervical hysterectomy (LSCH) in patients with endometriosis. A minimally invasive approach is usually preferred for surgery in endometriosis patients due to refractory to medical management, or for deep infiltrating type. Hysterectomy options include total or supracervical hysterectomies, where the cervix is not removed. The authors investigated the association…
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Reducing False Negatives in Endometriosis Histology Through Deeper Sections
A group of researchers led by gynecopathologist Professor Joseph Rabban has published their findings in the International Journal of Gynecological Pathology, evaluating the diagnostic utility of deeper tissue sections in biopsies from patients with suspected endometriosis. The definitive diagnosis of endometriosis relies on histopathologic examination of biopsied tissue. Interestingly, the diagnostic yield of histopathologic confirmation in clinically suspected peritoneal biopsies ranges from 51% to 89.5%. In some cases, small ectopic endometrial tissue foci in peritoneal biopsies may go undetected, resulting…
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Endometriosis and Ovarian Cancer: A Genetic Connection
Academicians Zhang and Yan from Ningbo University, Zhejiang, China, have recently published a pivotal study in Scientific Reports examining the cancer risk associated with endometriosis. Endometriosis, a chronic condition affecting approximately 6–10% of women worldwide, significantly diminishes quality of life through a range of debilitating symptoms. Alarmingly, individuals with endometriosis also appear to face an elevated risk of developing cancer. While several observational studies have addressed the potential malignancy risk linked to endometriosis, the precise impact of this condition on…
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Understanding Fibrosis in Endometriosis
Fibrosis is a crucial aspect of endometriosis, present in and around endometriosis lesions. It mainly arises from myofibroblasts—cells that transform through specific processes. Fibroblast-to-myofibroblast transdifferentiation, epithelial-to-mesenchymal transition, and, to a lesser extent, endothelial-to-mesenchymal transition are sources of myofibroblasts in endometriosis. The growth factor TGF-β is key in this transformation. Myofibroblasts not only create a stiff environment by depositing a matrix but may also contribute to the pain, so many patients experience. Interestingly, the fibrosis seen in endometriosis resembles that of…
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Cellular mechanisms in endometriosis revisited
Academicians from Kashihara and Nara, Japan led by Dr. Kobayashi have published their review on the cellular mechanisms of endometriotic tissues in a recent issue of Reproductive Medicine and Biology. Endometriosis is a common global gynecologic ailment affecting millions of women. Endometrial cells that regurgitate into the peritoneal cavity face low oxygen levels and lack of nutrients. To survive these harsh conditions, endometriotic cells have developed several adaptive homeostatic strategies in their microenvironments, including evading programmed cell death (apoptosis). Autophagy,…
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Artificial intelligence and Endometriosis
Academicians led by Dr. Yong from Vancouver, Canada, have published a timely review on the utility of Artificial Intelligence (AI) in endometriosis. This review appeared in a recent issue of the BMJ Woman’s Health. As a well-known issue, endometriosis poses important obstacles in terms of diagnosis and treatment so that diagnosis could be delayed an average of 8–12 years, and many patients suffer from pain and other nasty symptoms without proper management. AI is currently being applied to drug development,…
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Nanotechnology for endometriosis
Dr.Talukdar from Morehouse School of Medicine, Atlanta, GA, and colleagues have published a timely review of nanoparticle applications in endometriosis. This review appeared in the June 2024 issue of the journal “Nanomaterials”. As envisioned by Professor Ehrlich in the 19th century, nanoparticles could dissolve insoluble drugs, protect therapeutics from degradation, extend drug circulation times, and target drugs directly to disease sites, thereby reducing systemic toxicity. Recent studies suggest that nanoparticles have the potential to enhance medical procedures such as chemotherapy,…
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The most influential adverse effects of endometriosis
Academicians from the Queen’s University, Ontario Canada led by Dr. Velez published their population-based cohort study related to pregnancy complications in a recent issue of the Journal of Obstetrics and Gynaecology Canada. This population-based cohort study analyzed the association between endometriosis and severe maternal morbidity, and possible effects of infertility and fertility treatment in this regard. Severe maternal morbidity consists of life-threatening conditions occurring during the first 42 days (or within 6 weeks) of gestation. As it is well accepted, endometriosis has pathogenetic pillars of…
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Increasing evidence suggests that endometriosis should be considered a systemic disease
Professors Tulandi from McGill University, Canada, and Vercellini from Milano University, Italy, have recently published their expert opinion on endometriosis as a systemic disorder in Reproductive Biomedicine Online (RBMO). The contemporary view on endometriosis is suggestive of a type of chronic inflammatory disease with long-term adverse consequences such as cardiovascular disease or cancer. Recent research has yielded links between endometriosis and vascular diseases namely; atherosclerosis, migraine, and Raynaud syndrome. The proposed detrimental effect on endothelia may even result in pre-eclampsia…
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New horizons in endometriosis and immunity
Academicians led by Dorota Suszczyk from Lublin, Poland have published their recent comprehensive narrative review on immunity and endometriosis in International Journal of Molecular Sciences. Recent evidence points to the importance of co-inhibitory immune checkpoints which could be related to endometriosis mechanisms that we were unaware of. The authors have made a comprehensive literature overview conducting search via the PubMed/Medline/Scopus database, with a combination of medical subject headings terms, and keywords related to immunity and endometriosis. Endometriosis seems to be associated with…
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Rare but clinically important diagnosis; Herlyn-Werner-Wunderlich syndrome
The staff of the Department of Ultrasonography, Third Xiangya Hospital Central South University, Hunan, China have published their case series of the rare Herlyn-Werner-Wunderlich syndrome (HWWS) in a recent issue of Reproductive Sciences. HWWS, is a rare genital tract anomaly first noticed in 1922, with uterine didelphys, blind hemivagina, and ipsilateral renal agenesis. Although Obstructed Hemivagina and Ipsilateral Renal Anomaly, (OHVIRA) was also suggested for this compilation in 2007, HWWS has gained wide acceptance. The authors have revealed 85 cases having…
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Low-grade albeit longstanding inflammation may have a pivotal role in the ovary
Academicians from Japan led by Associate Professor Makoto Orisaka published their update related to the role of inflammation in polycystic ovaries, endometriosis, and aging in the medical journal Frontiers in Endocrionology. Inflammation is the response of tissues to noxious stimuli that may be acute, longstanding, i.e. chronic, and may have adverse outcomes on the body even though being a defensive action involving vessels and white blood cells. In this regard, chronic low-grade inflammation may have adverse effects on many ovarian reproductive…
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The role of immunity in endometriosis
Academicians from Japan and China have recently published their comprehensive updated immunological review for endometriosis in the Journal of Reproductive Immunology. Endometriosis is a multifactorial condition with multiple theories of pathogenesis. The role of innate and adaptive immunology in this regard has not been unveiled yet. However, scientific research related to immunity in endometriosis has been restricted to observational papers. Innate immunity seems to play an important role in the pelvic environmental milieu, especially in retrograde menstruation of endometrial cells. In unilateral…
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