Nasuhi Engin Aydin, MD

Nasuhi Engin Aydin, MD is a graduate of Hacettepe University Faculty of Medicine, Ankara with ECFMG Certification. He started his academic career at Ankara University working on short-term carcinogenicity tests, supported by TUBITAK grant with his research cited in NCI, Bethesda Monograph 65. He has been working as a licensed Anatomic Pathologist in Turkey since 1983. Main topics of interest are anatomic and surgical pathology with published manuscripts mainly in gynecopath and forensics https://www.youtube.com/watch?v=cNq6VTWVk80

TSH receptor antibodies show promising results in the diagnostic workup of endometriosis

Dr. Svensson with collaborators from the Swedish Lund University has published their results on the possible role of TSH receptor antibodies as biomarkers in endometriosis diagnosis in a recent issue of “European Journal of Obstetrics & Gynecology and Reproductive Biology”. Possible pathophysiologic mechanisms in endometriosis include molecular abnormalities and a defective immune system enabling the growth of ectopic endometria. Besides, the presence of a wide range of autoimmune diseases, including thyroid disorders is known to be increased in endometriosis patients.…

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Understanding what we see: endometriosis laparoscopic appearance and microscopic verification

Chia-Sui Weng and colleagues from the Mayo Clinic, USA have published their results on laparoscopic appearances and microscopy of endometriotic lesions in “The Journal of Minimally Invasive Gynecology”. Even though the diagnosis of endometriosis has evolved greatly with advanced imaging techniques surgery with histopathologic evaluation is still the diagnostic gold standard. Nevertheless, this diagnostic pathway may have difficulties due to various factors depending on the patient and surgical pathologist. Laparoscopic biopsies yield opportunities in confirming endometriosis via the pathologist’s microscope…

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Organizing structural protein Ezrin and its active form in endometriosis biopsies

Dr. Alessandra Peloggia and colleagues from Brazil have published their results on immunostaining of Ezrin protein and its phosphorylated active form in endometrial tissues in a recent issue of “Clinics” Possible factors on endometrial cell implantation and proliferation in the pelvic cavity have been discussed extensively in research projects. However, there has been limited discussion regarding Ezrin and its active form Phospho-Ezrin in this regard. The authors aimed to assess the expression of Ezrin and its active form Phospho-Ezrin in…

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T-cell-targeted immunotherapy and immune checkpoint inhibitors for the treatment of endometriosis

Dr. Monika Abraimuk and colleagues from Poland published their review on "the importance of immunity in endometriosis" in a recent issue of the medical journal “Cellular Signaling”. A great challenge in contemporary medical issues is endometriosis which still lacks a full scientific understanding of the disease process and thus currently searching for effective therapies. The scientific database yields information on the involvement of immune cells in the pathogenesis of endometriosis, namely neutrophils and peritoneal macrophages along with chemicals aiding in…

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Do endometriosis patients have increased risk of stroke?

Dr. Leslie V. Farland and colleagues from the University of Arizona, published their prospective research on the risk of stroke in women with laparoscopically confirmed endometriosis in a recent issue of a scientific journal named  “Stroke”. Endometriosis is a chronic inflammatory gynecologic condition that seems to negatively affect cardiometabolic status through alterations in inflammatory, immunologic, and hormonal milieu. The study aimed to prospectively investigate the association between laparoscopically confirmed endometriosis and the risk of incident stroke during 28 years of…

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Endometriotic cyst fluid and the postoperative recurrence of endometriosis

Dr. Xinxin Xu and colleagues from the Department of Obstetrics and Gynecology, School of Medicine, Zhejiang University, China, published their research on the viability of endometrial cells in ovarian cyst fluids in a recent issue of  “Journal of Ovarian Research”. Following surgeries, all types of endometriosis may recur but the highest rates are seen in ovarian endometriomas, the recurrence rates are more than 9 and 15% at 3 and 5 years after excision. Mainly two procedures are used to prevent…

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Combined "Platelet-to-lymphocyte ratio and CA125" may be promising predictor for adhesions

Drs. Guo & Zhang from the Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China published their manuscript on the importance of combined "platelet-to-lymphocyte ratio and CA125 level" as a biomarker of endometriosis in a recent issue of the journal “Frontiers ın Oncology”. Currently, endometriosis is accepted as a local and systemic inflammatory disease even with tumor-like biological behaviors, including invasion, adhesion, recurrence, and metastasis. Unfortunately, adhesions may yield difficulties in surgical management, such as injury…

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Genomic evidence: The recognition of endometriosis as an inflammatory systemic disease

Dr. Bao and associates from Shangai-China published a new article on the genomic features of endometriosis that could yield information on its inflammatory basis and possible therapeutic potential in a recent issue of “Frontiers ın Immunology”. Endometriosis is a systemic process with multi-organ consequences leading to high comorbidity. Genomics-led target prioritization called ‘END’ yielded better findings than the customary approaches to provide genomic evidence for endometriosis as an inflammatory systemic disorder. Multi-step prioritization process was utilized as (i) the preparation of genomic…

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Would it be possible to diagnose endometriosis from a vaginal swab?

Ectopic endometrial tissues with new vessel formations in an inflammatory background have a component of mast cell-derived exosomal tRF-Leu-AAG-001 promoting inflammation and angiogenesis. This information is according to the paper published in a recent issue of the journal “BMC Women’s Health”, by Dr. Li and associates from Ningbo Women and Children’s Hospital, Ningbo, China.  Currently, laparoscopy with tissue biopsy is the gold standard for the diagnosis of endometriosis in clinical management strategies.  Eutopic and ectopic endometrial tissues (when present), and leucorrhea were…

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Soluble CD90 : a potential serum biomarker in endometriosis

Dr. Bochev and colleagues from several medical centers in Bulgaria published their research on the role of a possible serum biomarker in diagnosing endometriosis in a recent issue of the journal named “Disease Markers”. The definitive diagnosis of endometriosis, an ailment affecting millions of women worldwide currently depends on visual inspection of lesions in laparoscopy and microscopic examination of surgically excised tissues. This diagnostic approach is invasive, may carry risks of postoperative complications, and also it is not easily accessible…

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Immune cells in peritoneal endometriosis

Dr. Burcu Ersoy and associates from The University of Sydney, Australia, published their interesting study on surgically removed peritoneal endometriosis tissues in the journal named "F&S Science". It is still a dilemma how ectopic endometrial tissues attach to the peritoneum, persist and develop. The endometriotic foci show a variation in color due to their age ranging from clear vesicles and red to black and finally scarred white ones. Previous studies did not consider lesion age when assessing the immune cell environment. The…

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Is there a component of "microflora imbalance" in endometriosis?

Dr. Oishi and colleagues from Ryukyus and Mie Universities, Japan, published a prospective cohort study on the microbiota of the female genital tract in the journal "Reproductive Medicine and Biology". Recent studies have found a small number of bacteria in female peritoneal fluids and endometria, but it is unclear how this microbiota may affect human health. Also, the relationship between the microbiota of the female genital tract and endometriosis needs to be clarified. The discovery of a female genital tract…

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Preferential expression of some membrane type matrix metalloproteinase proteins

Dr. Maoga and associates from academic institutions located in Germany and Kenya have published their findings on the immunohistochemical expression of MT-MMP proteins, namely MT2-MMP (MMP15) and MT3-MMP (MMP16) in the eutopic endometrium of healthy and endometriotic patients; and also in adenomyosis and different types of endometriosis, in the journal named Diagnostics. Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases capable of degrading extracellular matrix and are involved in different physiological processes like cell proliferation, differentiation, angiogenesis, apoptosis, and cell migration. These…

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Atherosclerosis is augmented in laboratory mice by experimental endometriosis

Dr. Taylor group from Yale School of Medicine, New Haven, CT, USA has published their experimental study in the "American Journal of Obstetrics & Gynecology" on atherosclerosis following endometriosis induction in laboratory mice. The basic inflammation process in endometriosis patients seems to have systemic consequences and epidemiologic studies point to an increased cardiovascular health risk in women with this ailment. If a casual relationship between endometriosis and atherosclerosis can be shown, this potential complication may be prevented. Under normal conditions, laboratory…

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A novel contribution to patient management in endometriosis by immunohistochemistry

Dr. Tarumi and associates from the Kyoto Prefectural University of Medicine, Kyoto, Japan published their retrospective cohort study on the importance of progesterone receptors on recurring ovarian endometriosis in "The Journal of Clinical Endocrinology & Metabolism". Surgery for endometriosis is applied to a great number of patients and the postoperative recurrence rate of endometriosis is estimated to be from 21.5% up to 56.7% within 2 years of surgery. Unfortunately, recurrence following endometriosis surgery decreases the quality of life and increases pain…

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A revolutionary view on endometriosis related pain

Dr. Lydia Coxon and colleagues from Oxford University, UK, have recently published their cross-sectional study on the categorization of endometriosis-related pain in the journal "Frontiers in Pain Research". As a chronic inflammatory condition, endometriosis results in pelvic pain, dysmenorrhea, and dyspareunia not related to disease burden. In the current research, the prevalence of neuropathic-like pain in endometriosis using a questionnaire screening hypothesizes that endometriosis-associated pain would be classified as neuropathic in some women. Similar to other patients with neuropathic pain these…

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Non-invasive diagnostic tools for endometriosis revisited

Dr. Signorile and associates from the Italian Endometriosis Foundation have published the results of their retrospective study on a large cohort of endometriosis patients in a recent issue of the periodical, In Vivo. Endometriosis lacks precise scientific knowledge and this brings about an incredible underdiagnosis and undertreatment with a long interval of 8-12 years between the beginning of symptoms and the appropriate clinical diagnosis. Currently, there is not any non-invasive diagnostic tool for definitive diagnosis. The final diagnosis of endometriosis is…

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International Working Group's review on endometriosis classification systems

International Endometriosis Working Group including AAGL, ESHRE, ESGE, and WES published a comprehensive review on endometriosis classification, staging, and reporting systems in a recent issue of the journal named "Facts, Views & Vision in Obstetrics and Gynecology". Classification and staging systems have improved clinical management, especially in oncology, rheumatology, and Parkinson’s disease. Following the first suggestion for a classification system for endometriosis in 1973, various publications for endometriosis classification, staging, and reporting systems emerged, but there is still no international…

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An important enigmatic promoter of endometriosis: immune dendritic cells

Dr. Larinha and associates from a Brasilian academic center have published their comprehensive review on the role of immune dendritic cells in the pathogenesis of endometriosis in a recent issue of the "Journal of Reproductive Immunology". Antigen-presenting dendritic cells of the immune system present processed antigens to T cells to mediate between innate and adaptive immunity. Dendritic cells originate from bone marrow progenitors and are a heterogeneous group of immune cells with the ability to migrate from blood to lymphoid and…

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Immunotherapy in endometriosis: a challenging research topic

Dr. Maksym and associates from academic centers in Poland have published their comprehensive review on endometriosis emphasizing the immunological aspects of the disease in a recent issue of the "Journal of Clinical Medicine". Even though endometriosis is a multifactorial disease, it is well known that the appearance of ectopic endometrial implants in the peritoneal cavity is possible due to immunological defects allowing the survival of abnormal tissues which would otherwise be cleared. It is well known that endometriosis is characterized…

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