Nasuhi Engin Aydin, MD
Nasuhi Engin Aydin, MD is a graduate of Hacettepe University Faculty of Medicine, Ankara with ECFMG Certification. He started his academic career at Ankara University working on short-term carcinogenicity tests, supported by TUBITAK grant with his research cited in NCI, Bethesda Monograph 65. He has been working as a licensed Anatomic Pathologist in Turkey since 1983. Main topics of interest are anatomic and surgical pathology with published manuscripts mainly in gynecopath and forensics.(Web of Science ResearcherID O-90432016 H-Index 20 as of 12/2022)
https://www.youtube.com/watch?v=cNq6VTWVk80
Rare but clinically important diagnosis; Herlyn-Werner-Wunderlich syndrome
The staff of the Department of Ultrasonography, Third Xiangya Hospital Central South University, Hunan, China have published their case series of the rare Herlyn-Werner-Wunderlich syndrome (HWWS) in a recent issue of Reproductive Sciences. HWWS, is a rare genital tract anomaly first noticed in 1922, with uterine didelphys, blind hemivagina, and ipsilateral renal agenesis. Although Obstructed Hemivagina and Ipsilateral Renal Anomaly, (OHVIRA) was also suggested for this compilation in 2007, HWWS has gained wide acceptance. The authors have revealed 85 cases having…
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Low-grade albeit longstanding inflammation may have a pivotal role in the ovary
Academicians from Japan led by Associate Professor Makoto Orisaka published their update related to the role of inflammation in polycystic ovaries, endometriosis, and aging in the medical journal Frontiers in Endocrionology. Inflammation is the response of tissues to noxious stimuli that may be acute, longstanding, i.e. chronic, and may have adverse outcomes on the body even though being a defensive action involving vessels and white blood cells. In this regard, chronic low-grade inflammation may have adverse effects on many ovarian reproductive…
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The role of immunity in endometriosis
Academicians from Japan and China have recently published their comprehensive updated immunological review for endometriosis in the Journal of Reproductive Immunology. Endometriosis is a multifactorial condition with multiple theories of pathogenesis. The role of innate and adaptive immunology in this regard has not been unveiled yet. However, scientific research related to immunity in endometriosis has been restricted to observational papers. Innate immunity seems to play an important role in the pelvic environmental milieu, especially in retrograde menstruation of endometrial cells. In unilateral…
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Postmenopausal endometriosis is often neglected
Romanian academicians led by Dr. Mihai-Daniel Dinu have published their review of the published scientific data related to postmenopausal endometriosis in a recent special issue of the medical periodical Life. Even though endometriosis is accepted as a hormone-dependent disorder of reproductive years, endometriosis in postmenopausal patients may occur in a similar way to endometriosis in premenopausal patients. Some researchers have claimed the potential involvement of the immune system in the development of endometriosis, Complaints of pelvic pain commonly underestimate the…
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Recommendations of experts on transvaginal ultrasonography
Following June 2022, the Society of Radiologists in Ultrasound composed of a panel of 16 experts in imaging and management of endometriosis, the recommendations have been published in a recent issue of Radiology. Transvaginal sonography is accepted as a first-line clinical step for pelvic pain and infertility besides being a second-line modality for preoperative visualization of endometriomas and deep endometriosis management. There is immense published literature describing the techniques on endometriosis, the Society of Radiologists in Ultrasound had a multidisciplinary…
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A comprehensive review of subdermal progestin in adenomyosis management
French academicians from Lyon and Marseilles led by Dr. Chene have published recently an electronic database search on the effectiveness of progestin subdermal implants in adenomyosis patients. This review appeared in the March 2024 issue of “The European Journal of Contraception & Reproductive Health Care” The long-acting reversible contraception progestin subdermal implant seems to be effective in ameliorating symptoms of endometriosis. Since adenomyosis is regarded as a histopathological form of endometriosis there is a question on the effectiveness of progestin subdermal…
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The depth of the iceberg: Parametrial involvement in deep endometriosis
Academicians led by members of the International School of Surgical Anatomy from Italy have published their paper on parametrial involvement of deep endometriosis in the medical periodical named “Best Practice & Research Clinical Obstetrics & Gynecology”. Deep endometriosis is troublesome when compared to the other endometriosis types due to the invasive properties beneath the peritoneum and also through the muscular layer of visceral organs. Few studies emphasize parametrial involvement is not a rare finding in patients with deep endometriosis who undergo surgery. This…
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Ovarian endometriomas revisited
Dr. Farr R. Nezhat and his world-renowned team have published their narrative review on ovarian endometrioma in a recent issue of the Obstetrics and Gynecology. Endometriotic cysts (endometriomas) of the ovaries range from small (1–3 cm) to large (20 cm or greater) masses that affect 6% of patients with ovaries. Endometriomas have potential risks of chronic pain, infertility, pregnancy complications, and also cancer transformation. Two favored pathogenetic views for endometriomas are; endometriotic invasion or metaplasia of preexisting functional ovarian cysts and…
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Sophisticated study yields hopes for a new potential remedy
Academicians from the Institute of Biomedical Sciences, Tokushima University Graduate School, Japan, conducted a clinical and experimental study on the role of SMAD (Suppressor of Mothers Against Decapentaplegic) molecules in endometriosis, and have published their results in a recent issue of Endocrine Journal. Activin is known to enhance the development of endometriotic lesions in laboratory mice. Also, a suppressor of mothers against decapentaplegic homolog 2/3 (pSAMA2/3) molecule in endometriotic lesions by immunostaining has been reported. Activin may therefore be involved in…
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Stem cells may open new horizons in various gynecological disorders
In-Sun Hong, PhD, a researcher in regenerative medicine at Korean Gachon University has published a comprehensive review on the role of stem cells in gynecological disorders in a recent issue of the International Journal of Biological Sciences. Endometrium changes the menstrual cycle and the extraordinary regenerative capacity depends on tissue-resident stem cells within the uterine mucosa. Despite variations in specific characteristics among endometrial stem cells, the common denominator is strong self-renewal capacity and the ability to differentiate into multiple cell types. The…
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Fact or fiction: prescribing medicinal cannabioids in endometriosis patients in Australia
A team of academic institutions from Australia has published their cross-sectional study on cannabis usage in endometriosis patients which has appeared in the recent issue of the Australian and New Zealand Journal of Obstetrics and Gynaecology. As victims of a chronic inflammatory ailment, endometriosis patients have been using cannabinoid-based medicinal products as well as illicit preparations for symptomatic relief worldwide. Though legal medicinal cannabis products are being used by endometriosis patients commonly, there is a high cost of prescription necessitating…
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Hot research in endometriosis; new vessel formation: angiogenesis
Caixia Bo and Yunfei Wang from Jining Medical University, China have recently published their comprehensive review on angiogenesis-related aspects of endometriotic tissues in a recent issue of journal named Molecular Medicine Reports. The main potential pathogenetic aspects of endometriosis include retrograde menstruation, uterine stem cells, and somatic epithelia. Whichever theory is operative, ectopic endometria needs nutrient support via new vessel formations, i.e., angiogenesis is the key factor for the viability of these ectopic islands. The authors have made literature search for…
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Inguinal endometriosis is a commonly neglected differential diagnosis
A case series of inguinal endometriosis with eight patients from Tehran, Iran has appeared in a recent issue of the Journal of Medical Case Reports. It is a fact that many inguinal endometriosis cases are undiagnosed since they undergo herniorrhaphy by surgeons without any consideration for endometriosis. The estimated incidence of inguinal involvement is about 0.3–0.6% in all endometriosis cases and the total number of reported cases is 133 till 2022. This report presents eight Iranian cases of inguinal endometriosis…
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Chronic stress may be involved both in the pathogenesis and progression of endometriosis
Chong Lu and associates from Shangai, China have published their novel research on chronic stress and endometriosis in a recent issue of International Journal of Molecular Sciences. During the natural course of endometriosis many patients are under chronic stress, which may yield depression, anxiety, and low social support, however, there is also an intriguing dilemma whether chronic stressful environment could cause endometriosis too. Patients confirmed as having endometriosis via intraoperative pathology consultations were recruited from the Fudan University Affiliated Obstetrics…
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Hands-on proposals for medical counseling and verbalizations to use for women with endometriosis
An overview has been published recently in the Archives of Gynecology and Obstetrics on patient–doctor communication and psychological counseling in endometriosis by two academicians, Drs. Wischmann and Ditzen, from Heidelberg University, Germany. There is no known cure for endometriosis and primary management aims at controlling and ameliorating the symptoms. Since the stressful chronicity of endometriosis, the patients may feel passive/dependent and helpless during the natural course of the ailment. Interventions aimed primarily at women with traumas may also be helpful in the…
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Clinical awareness for endometriosis in infertility should be surged
A team of researchers from multiple centers including Stanford University and Swiss Federal Laboratories, led by Dr.Camran Nezhat have published their cross-sectional retrospective study on endometriosis and unexplained infertility association. This research paper appeared in a recent issue of the Journal of Clinical Medicine. It is a pity that potential stigma and healthcare access problems may hamper the diagnosis of endometriosis for about 11 years. Endometriosis patients face the physical and emotional burdens of the ailment, including chronic pain, dysmenorrhea, dyspareunia,…
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Endometriosis vs. adenomyosis : is there a common pathogenesis ?
This is a collaborative review on the pathophysiology of adenomyosis and endometriosis by academicians of the University of Leicester, UK; Fudan University, Shanghai, China and Sapienza University of Rome, Italy, published in a recent issue of “Biomolecules”. The pathophysiology of endometriosis and adenomyosis remain still unresolved but a critical analysis of our current understanding is crucial. The so-called “endometrial determinism” theory is based on the hypothesis of abnormal endometrium as a predisposing factor for endometriosis whereas the tissue injury and…
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Could brain-derived neurotrophic factor (BDNF) be a potential marker of endometriosis ?
Medical student Kyana Jafarabady and academicians from several medical centers in Iran have published their database research on Brain-derived neurotrophic factor (BDNF) in endometriosis patients in a recent issue of BMC Women’s Health. BDNF is a neurotrophin that plays an important role in the development, survival, and plasticity of neurons of the central nervous system. However scientific research suggests that it is also expressed in peripheral tissues, including the reproductive system. High levels of BDNF have been reported in the peritoneal fluid,…
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New visions on diaphragmatic endometriosis
Elvin Piriyev and Thomas Römer from Academic Hospital Cologne Weyertal, Germany have published their retrospective analysis of diaphragm endometriosis in a recent issue of the European Journal of Obstetrics and Gynecology. About 7-10% of reproductive-age women have endometriosis but diaphragm involvement is estimated to be around 1.1 % among these patients. Diaphragm endometriosis frequently accompanies pelvic endometriosis and may either be symptomatic or asymptomatic. The authors aimed to investigate and present the clinical characteristics of diaphragm involvement, and to reveal whether…
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Beware of deep endometriosis involving ureter
Dr. Vacaroiu and colleagues from the Romanian academic milieu have published a case report of urinary tract endometriosis that could have otherwise resulted in kidney failure when remained undiagnosed. This case appeared in a recent issue of the Journal of Clinical Medicine. Extrapelvic endometriotic lesions are more commonly revealed in the 4th decade and are generally diagnosed about 5 years later than genital lesions. Less than 1% of endometriosis occurs in the urinary tract, often due to its subclinical progression. hydronephrosis…
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