Engin Aydin, MD

Nasuhi Engin Aydin,  M.D. a graduate of Hacettepe University Faculty of Medicine, Turkey received Philadelphia based E.C.F.M.G. Certification. He started his academic career at Ankara University working on short-term carcinogenicity tests with his research cited in NCI, Bethesda Monograph 65. He has been working as a registered Anatomic Pathologist in Turkey since 1983. Main topics of interest are research on gynecologic pathology besides forensic and surgical pathology with manuscripts published internationally. 

New findings in adenomyosis (endometriosis interna) patients with potential theraupetic research implications

Xue Shen and associates from Beijing, China have published their observations related to cannabinoid receptors, i.e., CB1 and CB2, in patients with adenomyosis, recently in the journal  "Biomed Research International".  Adenomyosis is an estrogen-dependent uterine disorder where a nonmalignant invasion of the bioactive endometrium into the myometrium occurs, and little is known about its etiology and its pathogenesis. Since uterus means a lot to women, medical therapy is important in the management of adenomyosis, and the rationale for it rests on…

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Adenomyosis (endometriosis interna): an enigmatic disease that has to be discovered yet

Scientists, Drs. Vannuccini and Petraglia from Italy have published an open access comprehensive review of Adenomyosis in "F1000Research" in March 2019 issue. Adenomyosis is a uterine disorder in which endometrial glands and stroma are pathologically demonstrated within the myometrium, i.e. uterine muscles. For years, adenomyosis has remained a microscopic tissue diagnosis made after hysterectomy in perimenopausal women with heavy menstrual bleeding or pelvic pain. However, adenomyosis has also become a condition identified in young fertile-age women due to recent advances in imaging techniques.…

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The role of adhesion molecules, E-cadherin and hScrib, in endometriosis

Dr. Zhuo Ouyang and associates from the Capital Medical University, Beijing, China have recently published their research related to adhesion molecules in "Medicine (Baltimore)". Endometriosis is a “benign gynecological disease with some similarities to cancer”. Adhesion molecules E-cadherin and hScrib have roles in the establishment of apical-basal polarity besides enhancing cell to cell adhesion, inhibition of cell proliferation and migration thus having an important role in physiological cellular homeostasis.   This retrospective study analyzed 240 women consisting of 80 ovarian endometriosis,…

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A highly sensitive Immunohistochemical Marker for Stromal Cells in endometriosis

Endometriosis is diagnosed histopathologically by the presence of endometrium-like tissues outside the uterus. Positive CD10 immunohistochemistry, highlighting stromal cells of the endometrium, is a useful adjunct for pathologists in the tissue diagnosis. However, CD10 expression is not specific to endometrial stromal cells and is found in other cells such as hematopoietic, renal tubular and smooth muscle cells. Previous studies of endometrial stroma and endometrial stromal neoplasms showed that IFITM1 is more specific to the endometrial stromal cells than CD10.  In this study…

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Anti-inflammatory cytokines: a new horizon in endometriosis with possible clinical relevance

Scientists led by Dr. Li from Shangai PRC, have made a comprehensive review of anti-inflammatory cytokines related to the pathogenesis of endometriosis in a recent issue of Cellular and Molecular Life Sciences.    Inflammation is important in the pathogenesis of endometriosis, particularly at the early stages thus it is stated that endometriosis is an inflammatory disease. It is well known that increased levels of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and IL-17A, are present in the…

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Nutraceuticals may help for endometriosis pain

 Dysmenorrhea and chronic pelvic pain occur in endometriosis patients in a significant percentage. Anti-inflammatory medications and lifestyle changes including diet form the integrated approach in this regard. However, the medications can be used only for the short term. Natural substances with anti-inflammatory properties for this purpose may be effective. Italian physicians conducted a multi-center prospective study on 60 women aged between 20 and 39 with ovarian endometrioma and chronic pelvic pain for one year. The results were published in "Minerva Ginecologica". All women…

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Endometriosis and infertility: current concepts

Hungarian and US scientists have published a comprehensive review on infertility related to endometriosis in Frontiers in Endocrinology, November 2018 issue.  Endometriosis is a common entity in women of reproductive age which often leads to infertility. Compiled research data reveal that endometriosis induces decreased quantities of oocytes and embryos, besides causing decreased embryo quality, and decreased implantation and pregnancy rates.  IVF/ICSI patients with endometriosis have shown decreased quantity and quality of oocytes and embryos. Retrograde menstruation, a working hypothesis for endometriosis,…

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Additional research in understanding the causative link between Notch signaling and endometriosis

Dustin M. Brown and associates from the University of Arkansas for Medical Sciences published their unique complex molecular research in the Journal of the Endocrine Society. This study group previously showed that decreased expression of the progesterone receptor (PGR) resulted from aberrant activation of Notch-1 signaling in mouse uteri. Since the blockage of Notch-1 activation may help clinical management of endometriosis, studies to understand the causative link between Notch signaling and endometriosis are valuable. Eutopic endometria and endometriotic lesions of surgically diagnosed patients…

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New scientific evidence supporting robotic surgical approach to ureteric endometriosis

Surgical treatment of ureteral endometriosis aims to relieve urinary obstruction besides preserving renal functions. In accomplishing these, the best method of surgical approach is still unclear. Andrea Giannini and her colleagues from the University of Pisa, Italy conducted a retrospective study reviewing 31 consecutive patients who underwent robotic-assisted laparoscopic excision of endometriosis with ureteral involvement in a six-year period and published the results in Frontiers in Surgery. Surgery was performed using da Vinci Si and Xi robotic systems by expert gynecologic…

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Factors related to delay in endometriosis diagnosis

Dr. Moniek van der Zanden, a gynecologist from Netherlands has recently made a nationwide survey on the impact of key recommendations of the European Society of Human Reproduction and Embryology (ESHRE) guidelines on endometriosis and aimed to assess factors influencing diagnostic delay of endometriosis. The paper was recently published in the journal Reproductive Biomedicine Online. A nationwide cross-sectional questionnaire study with 56 questions, including 38 multiple choice and 18 open-ended types, was conducted among all hospitals in the Netherlands. This questionnaire addressed demographic…

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Presumed molecular mechanisms for herbal medicinal therapies in endometriosis

Pharmaceutical agents for the management of endometriosis are associated with side effects and are not completely effective. In regard to this, Bina and associates from Tehran University of Medical Sciences have reviewed extensively the literature for herbal remedies. Herbal medicinal products used for the management of endometriosis and their possible mechanisms of action have been summarized after searching different electronic databases including PubMed, Scopus, Cochrane library and Google Scholar. Data collected from 1980 to 2018 of studies investigating the effect of herbal…

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Growth Hormone-Inhibiting Hormone: Somatostatin and its receptors in endometriosis

Yanhua Zhao and colleagues, led by Dr.Zhang from Hunan, China reported their recent research at Experimental and Therapeutic Medicine.  Somatostatin is a natural polypeptide extensively distributed in the digestive and nervous system, exhibiting several biological effects with a restricted clinical application due to its short half‑life in vivo. The somatostatin analog (SSTA) is advantageous due to its long half‑life, relatively long‑lasting effect, high selectivity and the ease of appli­cation. Previous studies had revealed that somatostatin inhibits the proliferation of tumor cells…

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Four cases of endometrioid borderline ovarian tumour: case reports and literature review

Physicians from Kyoto University Graduate School of Medicine, Kyoto, Japan, report four cases of ovarian EBTs and a review literature in a recently published manuscript at British Medical Journal, case reports. Endometrioid borderline tumors (EBTs) of the ovary are uncommon tumors of low malignancy, consisting of atypical endometrioid cells lacking destructive stromal invasion like cancer tissue. As the prognosis of EBT is excellent, overtreatment has to be avoided and correct definitive diagnosis is extremely important. Here the average patient age…

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Vitamin D and Endometriosis

Scientists from Milan, Italy reviewed the effects of vitamin D on the reproductive health, and in particular "endometriosis" in their article which appeared in International Journal of Molecular Sciences. Vitamin D (VD), is a steroid hormone that is activated in the skin, under UVB light, undergoes two more hydroxylation steps mainly in the liver and in the proximal tubules of the kidneys; that mainly acts by VD receptor (VDR) that belongs to the nuclear receptor superfamily to interact with the…

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Angiotensin receptor MAS1 may have a role in the pathogenesis of endometriosis

Takahiro Nakajima and colleagues from Nihon University School of Medicine, Tokyo, Japan report their novel findings on Angiotensin receptor MAS1 in the pathogenesis of endometriosis in Gynecologic and Obstetrics Investigation. The renin-angiotensin system (RAS) is an activation cascade playing a key role in the regulation of blood pressure besides water and electrolyte balance. RAS also plays important roles in regulating tissue remodeling, tissue thickening, and sclerosis; and is particularly involved in cell proliferation, angiogenesis, and apoptosis. Renin cleaves angiotensinogen into…

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Thoracic Endometriosis Syndrome (TES): Diagnosis by cytology of pleural effusion

Parikshaa Gupta and colleagues from Chandigarh, India report a case of thoracic endometriosis diagnosed primarily by pleural fluid cytology in a most recent article at Cytopathology. A 33-year-old female presented with a long history of recurrent bouts of chest pain associated with a dry cough and breathlessness, with some of the episodes coinciding with her menses. Most of these episodes were self-limited and responded to oral analgesics.  Additionally, she was being evaluated for primary infertility. Her elder sister had infertility…

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Commentary on major developments in the pathophysiology of endometriosis

This commentary article by Dr. Warren G. Foster, from MacMaster University, Canada that appeared at Biology of Reproduction, is highly valuable for its leading role in endometriosis research. Although endometriosis is a common disease affecting up to 10% of women, frequently causing pelvic pain and infertility its etiology remains a myth. Basically, it is an estrogen-dependent disease having endometrial tissue outside the uterine cavity. While retrograde menstruation is the most widely accepted theory of causation, regurgitation of menstrual effluent through…

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The pathogenesis of endometriosis : New discoveries with clinical impact

In this recent review article that appeared in Current Women’s Health Reviews, compiled by researchers from the Department of Molecular Cell Biology and Human Genetics, Institute of Cell Biology and Neuroscience Frankfurt, Germany the following important points in regard to the molecular and cellular pathogenesis of endometriosis were outlined. In respect to a main implantation pathogenetic theory of endometriosis, the most likely explanation for the pathologic lesions of endometriosis shed menstrual endometrium is also flushed back into the pelvis. Menstrual cells can attach by gravity to the peritoneal…

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Epigenetic link between endometriosis and cancer

Although endometriosis is considered a benign condition the cellular, histologic, and molecular data strongly demonstrate that endometriosis has neoplastic characteristics. There is strong evidence that endometriosis shares striking features with malignancy like normal tissue dissemination, invasion, and organ damage, as well as new vessel formation (neoangiogenesis).  In the review entitled "Endometriosis malignant transformation: Epigenetics as a probable mechanism in ovarian tumorigenesis", recently published in the International Journal of Genomics, Jiaxing et al from China, summarize specifically the research concerning the relationship between endometriosis and ovarian cancer and epigenetic modifications.…

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