Nasuhi Engin Aydin, MD

Nasuhi Engin Aydin, MD is a graduate of Hacettepe University Faculty of Medicine, Ankara with ECFMG Certification. He started his academic career at Ankara University working on short-term carcinogenicity tests, supported by TUBITAK grant with his research cited in NCI, Bethesda Monograph 65. He has been working as a licensed Anatomic Pathologist in Turkey since 1983. Main topics of interest are anatomic and surgical pathology with published manuscripts mainly in gynecopath and forensics.(Web of Science ResearcherID O-90432016 H-Index 20 as of 12/2022)

https://www.youtube.com/watch?v=cNq6VTWVk80


Hot research in endometriosis; new vessel formation: angiogenesis

Caixia Bo and Yunfei Wang from Jining Medical University, China have recently published their comprehensive review on angiogenesis-related aspects of endometriotic tissues in a recent issue of journal named Molecular Medicine Reports. The main potential pathogenetic aspects of endometriosis include retrograde menstruation, uterine stem cells, and somatic epithelia. Whichever theory is operative, ectopic endometria needs nutrient support via new vessel formations, i.e., angiogenesis is the key factor for the viability of these ectopic islands. The authors have made literature search for…

Key Points Lay Summary

Inguinal endometriosis is a commonly neglected differential diagnosis

A case series of inguinal endometriosis with eight patients from Tehran, Iran has appeared in a recent issue of the Journal of Medical Case Reports. It is a fact that many inguinal endometriosis cases are undiagnosed since they undergo herniorrhaphy by surgeons without any consideration for endometriosis. The estimated incidence of inguinal involvement is about 0.3–0.6% in all endometriosis cases and the total number of reported cases is 133 till 2022. This report presents eight Iranian cases of inguinal endometriosis…

Key Points Lay Summary

Chronic stress may be involved both in the pathogenesis and progression of endometriosis

Chong Lu and associates from Shangai, China have published their novel research on chronic stress and endometriosis in a recent issue of International Journal of Molecular Sciences. During the natural course of endometriosis many patients are under chronic stress, which may yield depression, anxiety, and low social support, however, there is also an intriguing dilemma whether chronic stressful environment could cause endometriosis too. Patients confirmed as having endometriosis via intraoperative pathology consultations were recruited from the Fudan University Affiliated Obstetrics…

Key Points Lay Summary

Hands-on proposals for medical counseling and verbalizations to use for women with endometriosis

An overview has been published recently in the Archives of Gynecology and Obstetrics on patient–doctor communication and psychological counseling in endometriosis by two academicians, Drs. Wischmann and  Ditzen, from Heidelberg University, Germany. There is no known cure for endometriosis and primary management aims at controlling and ameliorating the symptoms. Since the stressful chronicity of endometriosis, the patients may feel passive/dependent and helpless during the natural course of the ailment. Interventions aimed primarily at women with traumas may also be helpful in the…

Key Points Lay Summary

Clinical awareness for endometriosis in infertility should be surged

A team of researchers from multiple centers including Stanford University and Swiss Federal Laboratories, led by Dr.Camran Nezhat have published their cross-sectional retrospective study on endometriosis and unexplained infertility association. This research paper appeared in a recent issue of the Journal of Clinical Medicine. It is a pity that potential stigma and healthcare access problems may hamper the diagnosis of endometriosis for about 11 years. Endometriosis patients face the physical and emotional burdens of the ailment, including chronic pain, dysmenorrhea, dyspareunia,…

Key Points Lay Summary

Endometriosis vs. adenomyosis : is there a common pathogenesis ?

This is a collaborative review on the pathophysiology of adenomyosis and endometriosis by academicians of the University of Leicester, UK; Fudan University, Shanghai, China and Sapienza University of Rome, Italy, published in a recent issue of “Biomolecules”. The pathophysiology of endometriosis and adenomyosis remain still unresolved but a critical analysis of our current understanding is crucial. The so-called “endometrial determinism” theory is based on the hypothesis of abnormal endometrium as a predisposing factor for endometriosis whereas the tissue injury and…

Key Points Lay Summary

Could brain-derived neurotrophic factor (BDNF) be a potential marker of endometriosis ?

Medical student Kyana Jafarabady and academicians from several medical centers in Iran have published their database research on Brain-derived neurotrophic factor (BDNF) in endometriosis patients in a recent issue of BMC Women’s Health. BDNF is a neurotrophin that plays an important role in the development, survival, and plasticity of neurons of the central nervous system. However scientific research suggests that it is also expressed in peripheral tissues, including the reproductive system. High levels of BDNF have been reported in the peritoneal fluid,…

Key Points Lay Summary

New visions on diaphragmatic endometriosis

Elvin Piriyev and Thomas Römer from Academic Hospital Cologne Weyertal, Germany have published their retrospective analysis of diaphragm endometriosis in a recent issue of the European Journal of Obstetrics and Gynecology. About 7-10% of reproductive-age women have endometriosis but diaphragm involvement is estimated to be around 1.1 % among these patients. Diaphragm endometriosis frequently accompanies pelvic endometriosis and may either be symptomatic or asymptomatic. The authors aimed to investigate and present the clinical characteristics of diaphragm involvement, and to reveal whether…

Key Points Lay Summary

Beware of deep endometriosis involving ureter

Dr. Vacaroiu and colleagues from the Romanian academic milieu have published a case report of urinary tract endometriosis that could have otherwise resulted in kidney failure when remained undiagnosed. This case appeared in a recent issue of the Journal of Clinical Medicine.  Extrapelvic endometriotic lesions are more commonly revealed in the 4th decade and are generally diagnosed about 5 years later than genital lesions. Less than 1% of endometriosis occurs in the urinary tract, often due to its subclinical progression. hydronephrosis…

Key Points Lay Summary

A unique approach for visualising endometriosis during surgery

Dr. Jing Peng and associates from Shangai, China have made an experimental study on precise visualization of endometriotic lesions with gonadotropin-releasing hormone analog-modified indocyanine green, publishing their results in the Journal of Molecular Imaging.  Surgical interventions are important aspects of endometriosis and precise intraoperative specification and excision of lesions are critical. Imaging substances are of utmost importance in this regard and methylene blue, 5-Aminolevulinic acid (5- ALA), and several others have been proposed during intraoperative visualization for endometriosis. Indocyanine green…

Key Points Lay Summary

A herbal product has promising results in experimental endometriosis

Neroli oil (bitter orange) is a nontoxic volatile substance from the flowers of Citrus aurantium that belongs to the Rutaceae family. This oil has notable anti-inflammatory effects besides potent antioxidant activity with 100% singlet oxygen scavenging activity. Contemporary pathophysiological views on endometriosis emphasize inflammatory etiology besides oxidative stress as the initiators and perpetuators of this notorious disease. Proinflammatory cytokines take major roles and progression of endometriotic lesions while vascularization has a crucial effect. Dr. Mujde Canday and colleagues from Kars Kafkas…

Key Points Lay Summary

Analysis of steroid hormone receptors in endometriotic tissues reveals chaotic results

  A group of researchers from academic institutions located at Australia and New Zeland, led by Dr. Holdsworth-Carson, have published their recent findings on steroid receptors in peritoneal endometriosis lesions by immunohistochemistry, in the journal Reproduvtive Biomedicine Online.  Endometriosis is notoriously disabling disease affecting millions of women worldwide, and both medical and surgical tmanagement are far from perfect, leading the welfare of the patients to jeopardy. Oral contraceptives, progestins, levonorgestrel-releasing intrauterine devices and several other hormonal theraupetics are frequently used…

Key Points Lay Summary

Quantification of nerve bundle density as a biomarker for endometriosis utilizing PGP9.5 immunostaining

Scientists from Netherlands and Canada have published their authentic study on immunohistochemically assessed nerve fiber bundles of endometriotic tissues in a recent issue of  Frontiers in Reproductive Health. Endometriotic tissues have nerve fibers which are stimulated in inflammatory processes leading to increased physical stimuli. In this context, local neuroproliferation or "neurogenesis" may have a role, as quantitative increase in nerve fibers around endometriotic tissues are shown. However, pelvic pain symptoms are quite different among endometriosis patients so that revised American Society…

Key Points Lay Summary

Increasing awareness of the scientific community on nano-particles for endometriosis.

Academicians from various disciplines from multiple Italian institutions have published their review on the possible role of nanotechology to deal with the management of endometriosis in a recent issue of scientific periodical Nanoscale. Nanotechnology is the science and engineering where nanoscale phenomena occur, and currently attracts widespread enthusiasm in the medical arena. This enthusiasm originates from the fact that, nanoparticles seem to have potential in enhancing conventional therapies and imaging modalities for both detection and treatment of various medical remedies.  There…

Key Points Lay Summary

Could H1-antihistamines be beneficial in endometriosis management ?

K. B. Manthra, PhD, a postdoctoral researcher from the University of Minnesota has written a “clinical opinion” in a recent issue of the periodical American Journal of Obstetrics and Gynecology, Global Reports. Endometriosis is currently regarded as a chronic inflammatory gynecologic process among women of reproductive age. This ailment causes many symptoms affecting the quality of life and mental status of many women worldwide. There is a close relation between inflammatory mediators, and estrogenic hormones, along with immune cells in the…

Key Points Lay Summary

Reviewing all you want to know on endometriosis !

Academicians from the International University of Sarajevo, Bosnia, and Lincoln Medical School, UK have written a comprehensive updated review on endometriosis covering many aspects of endometriosis and published their paper as an open-access manuscript in the journal “Pathology-Research and Practice”.  Endometriosis affects around 6–10% of reproductive-age women all over the world, causing debilitating pain, heavy menstrual bleeding, pain during sexual intercourse, and infertility. The etiology has not been fully revealed yet. However, it is generally accepted that the endometriotic lesions…

Key Points Lay Summary

Asia-Pacific: Expert panel's suggestions for improving endometriosis-related health issues

"Endometriosis should be diagnosed as early as possible for the sake of the patients" and the Asia-Pacific Endometriosis Expert Panel sought to address the reasons for diagnostic delays in this part of the world and published a consensus report in a recent issue of the "International Journal of Gynecology and Obstetrics".  It is a widely known scientific reality that Asian women have relatively high rates of endometriosis when compared to white female populations elsewhere. 60% of the total world population is…

Key Points Lay Summary

Endometriosis in Asia

Academicians from the University of Philippines led by Dr. Velarde have published a recent review on endometriosis and Asian women in the scientific periodical “Endocrine Connections”. The endometriosis prevalence rate is variable among ethnicities, and Asian women including Filipinos, Indians, Japanese, and Koreans are more likely to be diagnosed with endometriosis compared to Caucasian women with an odds ratio of 1.63.  In spite of the high rates of endometriosis in Asians, data on endometriosis and funding support for research are still highly…

Key Points Lay Summary

Vicious cycle: The promoting role of previous endometriosis foci for new lesions

An experimental animal study on the pathogenesis of endometriosis from the Institute for Clinical and Experimental Surgery, Saarland University, Hamburg has been published in a recent issue of International Journal of Molecular Sciences. Endometriosis is a well-known common gynecological ailment characterized by endometrial tissues located ectopically. Most patients have endometriotic lesions on intraabdominal peritoneal surfaces. The most popular pathogenetic postulation for endometriosis is the retrograde transfer of eutopic endometria through Fallopian tubes into the abdomen and adherence to the peritoneal…

Key Points Lay Summary

Omitted facet of endometriosis : mental health related to stigma

A team of clinical psychologists involved in women’s health led by Deniz Kocas has published a recent review on the mental health aspect of endometriosis patients in the European Journal of Obstetrics & Gynecology and Reproductive Biology. Endometriosis is a notoriously complex disease through not well-understood pathogenesis along with multifaceted presentations in patients leading to complicated issues in women’s health worldwide. "Stigma", defined as an “attribute that is deeply discrediting”, also affects the psychosocial milieu of endometriosis patients widely. Stigma sets…

Key Points Lay Summary