Nasuhi Engin Aydin, MD
Nasuhi Engin Aydin, MD is a graduate of Hacettepe University Faculty of Medicine, Ankara with ECFMG Certification. He started his academic career at Ankara University working on short-term carcinogenicity tests, supported by TUBITAK grant with his research cited in NCI, Bethesda Monograph 65. He has been working as a licensed Anatomic Pathologist in Turkey since 1983. Main topics of interest are anatomic and surgical pathology with published manuscripts mainly in gynecopath and forensics. (Web of Science ResearcherID O-90432016 H-Index 20 as of 12/2022)
https://www.youtube.com/watch?v=cNq6VTWVk80
From Finland : How to increase health issues in endometriosis patients
Dr. Henna-Riikka Rossi and associates from the University of Oulu, Oulu, Finland have published their recent prospective cohort study on possible existing comorbidities of endometriosis patients in the journal Fertility and Sterility. Endometriosis is an estrogen-dependent chronic ailment affecting about 6-10% of women which may be associated with painful periods, dyspareunia, chronic pelvic pain, abdominal bloating, nausea, fatigue, and sometimes depression, anxiety, and infertility. Besides, this common gynecological disorder seems to have an increased risk of other health issues like…
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Is the pathogenesis of endometriosis hidden in immune-related gene profiles ?
Yanan He and colleagues from the Department of Gynecology, Harbin Medical University, China have published their manuscript on potential immune markers in endometriosis in a recent issue of “Journal of Immunology Research” Pathophysiologic mechanisms involving endometriosis are complicated and have various parameters like local inflammation, proliferation, invasion, and angiogenesis of endometrial cells. All these have not been well understood yet. The majority agrees that immune factors have a major role in the viability of ectopic endometria with depressed immunosurveillance and…
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Diaphragmatic Endometriosis: a Call for Awareness
Dr. Pagano and colleagues from the Department of Gynecology and Obstetrics, University of Bern, Switzerland, have published a prospective cohort study on diaphragmatic involvement in endometriosis patients in a recent issue of “The Journal of Minimally Invasive Gynecology”. Endometriosis is a common gynecological disorder that is seen predominantly in the pelvic area and, less frequently, in the upper abdomen and rarely in extra-abdominal organs. Following the first clinical description of diaphragmatic endometriosis in 1954, the estimated maximal prevalence is about 1.5%…
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Transvaginal ultrasound or MRI for retroflexed uterus in endometriosis
Dr Matsuda and colleagues from the Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan have published their study evaluating the effectiveness of transvaginal ultrasound on the diagnosis of uterine retroflexion in a recent issue of “Journal of Nippon Medical School”. Uterine retroflexion is a variant present in 20% of healthy women, but it is also associated with posterior deep endometriosis and adhesions in endometriosis. Adhesion or closure of the cul-de-sac obliteration is frequent in deep endometriosis which may…
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Scientific unfolding will lead new drug targets
Drs. Dolmans and Donnez from academic institutions located in Brussels, Belgium, have published their comprehensive review on the current pathophysiological concepts in endometriosis with possible drug treatment potentials in the recent issue of a scientific journal named “Biomolecules”. As a chronic inflammatory disorder, endometriosis causes distressing symptoms like pain and infertility in women of reproductive age. Even though each of the common pelvic forms, peritoneal, ovarian, and rectovaginal endometriosis has specific presentations, dysmenorrhea and chronic non-menstrual pelvic pain are the…
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Uterine leiomyomas and endometriosis may coexist yielding important clinical implications
Drs. Uimari, Nazri, and Tapmeier from Finland, the UK, and Australia have published their comprehensive review on the comorbidity of endometriosis along with uterine leiomyomas in the medical journal “Frontiers in Reproductive Health”. The comorbidity of uterine leiomyomas and endometriosis has been put forward by various recent large-population observational studies. Comorbidity incidence is much higher in retrospective studies conducted in tertiary medical referral centers than is reported in medical insurance documents. Both pathologies may yield severe pelvic pain, painful periods and…
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Rare but important entity: perineal endometriosis
Dr. Zhu and colleagues from Peking Union Medical College Hospital have published their retrospective research on "surgically treated perineal endometriosis cases" in a recent issue of BMC’s Women’s Health. Perineal endometriosis is a rare type of endometriosis accounting for at most 0.37% of women consulting for treatment of endometriosis. A literature search starting from 1923 for perineal endometriosis revealed around three hundred cases till 2021. Diagnosis and therapy could be problematic mainly due to its rarity and low awareness of…
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Uterine agenesis patients may have endometriosis too
Dr. Steinmacher and colleagues at the Tuebingen University Hospital, Germany have published their unique study on a series of patients with congenital Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome in a recent issue of the “Journal of Clinical Medicine”. The absence uterus and upper part of the vagina with normal secondary sex characteristics and normal female karyotype characterize congenital MRKH syndrome. The estimated incidence is about 1 of 4500 live female births. The reported incidence of the presence of uterine remnants varies from 50%…
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Efficacy of Uterine Artery Blockage in Endometriosis Management
Dr. Li Ma and associates from Liaoning, China have published their results of a computerized database search on the role of uterine artery embolization in endometriosis in a recent issue of the periodical “Computational Intelligence and Neuroscience”. Currently, the management of endometriosis consists of surgical interventions add hormonal therapy. This classic approach may slow down the development of endometriosis, and achieve the purpose of relieving the disease and inhibiting recurrence. Thinking that the application of uterine artery embolization in the…
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Antimicrobial agent ornidazole yields promising effects in an animal model of endometriosis
Xiaoduo Qin and collaborators from Chinese medical centers, have published their results on the role of ornidazole using an experimental rat model in a recent issue of the periodical “Gynecologic and Obstetric Investigation”. Progression of endometriotic foci depends on the presence of an adequate blood supply, i.e. angiogenesis, and chronic inflammatory response is also closely related in its pathogenesis. Ornidazole is a well-known antimicrobial agent with a strong anti-inflammatory effect besides possessing some antiangiogenetic and anticancer properties. In this regard, ornidazole could…
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TSH receptor antibodies show promising results in the diagnostic workup of endometriosis
Dr. Svensson with collaborators from the Swedish Lund University has published their results on the possible role of TSH receptor antibodies as biomarkers in endometriosis diagnosis in a recent issue of “European Journal of Obstetrics & Gynecology and Reproductive Biology”. Possible pathophysiologic mechanisms in endometriosis include molecular abnormalities and a defective immune system enabling the growth of ectopic endometria. Besides, the presence of a wide range of autoimmune diseases, including thyroid disorders is known to be increased in endometriosis patients.…
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Understanding what we see: endometriosis laparoscopic appearance and microscopic verification
Chia-Sui Weng and colleagues from the Mayo Clinic, USA have published their results on laparoscopic appearances and microscopy of endometriotic lesions in “The Journal of Minimally Invasive Gynecology”. Even though the diagnosis of endometriosis has evolved greatly with advanced imaging techniques surgery with histopathologic evaluation is still the diagnostic gold standard. Nevertheless, this diagnostic pathway may have difficulties due to various factors depending on the patient and surgical pathologist. Laparoscopic biopsies yield opportunities in confirming endometriosis via the pathologist’s microscope…
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Organizing structural protein Ezrin and its active form in endometriosis biopsies
Dr. Alessandra Peloggia and colleagues from Brazil have published their results on immunostaining of Ezrin protein and its phosphorylated active form in endometrial tissues in a recent issue of “Clinics” Possible factors on endometrial cell implantation and proliferation in the pelvic cavity have been discussed extensively in research projects. However, there has been limited discussion regarding Ezrin and its active form Phospho-Ezrin in this regard. The authors aimed to assess the expression of Ezrin and its active form Phospho-Ezrin in…
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T-cell-targeted immunotherapy and immune checkpoint inhibitors for the treatment of endometriosis
Dr. Monika Abraimuk and colleagues from Poland published their review on "the importance of immunity in endometriosis" in a recent issue of the medical journal “Cellular Signaling”. A great challenge in contemporary medical issues is endometriosis which still lacks a full scientific understanding of the disease process and thus currently searching for effective therapies. The scientific database yields information on the involvement of immune cells in the pathogenesis of endometriosis, namely neutrophils and peritoneal macrophages along with chemicals aiding in…
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Do endometriosis patients have increased risk of stroke?
Dr. Leslie V. Farland and colleagues from the University of Arizona, published their prospective research on the risk of stroke in women with laparoscopically confirmed endometriosis in a recent issue of a scientific journal named “Stroke”. Endometriosis is a chronic inflammatory gynecologic condition that seems to negatively affect cardiometabolic status through alterations in inflammatory, immunologic, and hormonal milieu. The study aimed to prospectively investigate the association between laparoscopically confirmed endometriosis and the risk of incident stroke during 28 years of…
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Endometriotic cyst fluid and the postoperative recurrence of endometriosis
Dr. Xinxin Xu and colleagues from the Department of Obstetrics and Gynecology, School of Medicine, Zhejiang University, China, published their research on the viability of endometrial cells in ovarian cyst fluids in a recent issue of “Journal of Ovarian Research”. Following surgeries, all types of endometriosis may recur but the highest rates are seen in ovarian endometriomas, the recurrence rates are more than 9 and 15% at 3 and 5 years after excision. Mainly two procedures are used to prevent…
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Combined "Platelet-to-lymphocyte ratio and CA125" may be promising predictor for adhesions
Drs. Guo & Zhang from the Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China published their manuscript on the importance of combined "platelet-to-lymphocyte ratio and CA125 level" as a biomarker of endometriosis in a recent issue of the journal “Frontiers ın Oncology”. Currently, endometriosis is accepted as a local and systemic inflammatory disease even with tumor-like biological behaviors, including invasion, adhesion, recurrence, and metastasis. Unfortunately, adhesions may yield difficulties in surgical management, such as injury…
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Genomic evidence: The recognition of endometriosis as an inflammatory systemic disease
Dr. Bao and associates from Shangai-China published a new article on the genomic features of endometriosis that could yield information on its inflammatory basis and possible therapeutic potential in a recent issue of “Frontiers ın Immunology”. Endometriosis is a systemic process with multi-organ consequences leading to high comorbidity. Genomics-led target prioritization called ‘END’ yielded better findings than the customary approaches to provide genomic evidence for endometriosis as an inflammatory systemic disorder. Multi-step prioritization process was utilized as (i) the preparation of genomic…
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Would it be possible to diagnose endometriosis from a vaginal swab?
Ectopic endometrial tissues with new vessel formations in an inflammatory background have a component of mast cell-derived exosomal tRF-Leu-AAG-001 promoting inflammation and angiogenesis. This information is according to the paper published in a recent issue of the journal “BMC Women’s Health”, by Dr. Li and associates from Ningbo Women and Children’s Hospital, Ningbo, China. Currently, laparoscopy with tissue biopsy is the gold standard for the diagnosis of endometriosis in clinical management strategies. Eutopic and ectopic endometrial tissues (when present), and leucorrhea were…
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Soluble CD90 : a potential serum biomarker in endometriosis
Dr. Bochev and colleagues from several medical centers in Bulgaria published their research on the role of a possible serum biomarker in diagnosing endometriosis in a recent issue of the journal named “Disease Markers”. The definitive diagnosis of endometriosis, an ailment affecting millions of women worldwide currently depends on visual inspection of lesions in laparoscopy and microscopic examination of surgically excised tissues. This diagnostic approach is invasive, may carry risks of postoperative complications, and also it is not easily accessible…
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