Nasuhi Engin Aydin, MD

Nasuhi Engin Aydin, MD is a graduate of Hacettepe University Faculty of Medicine, Ankara with ECFMG Certification. He started his academic career at Ankara University working on short-term carcinogenicity tests, supported by TUBITAK grant with his research cited in NCI, Bethesda Monograph 65. He has been working as a licensed Anatomic Pathologist in Turkey since 1983. Main topics of interest are anatomic and surgical pathology with published manuscripts mainly in gynecopath and forensics https://www.youtube.com/watch?v=cNq6VTWVk80

Would it be possible to diagnose endometriosis from a vaginal swab?

Ectopic endometrial tissues with new vessel formations in an inflammatory background have a component of mast cell-derived exosomal tRF-Leu-AAG-001 promoting inflammation and angiogenesis. This information is according to the paper published in a recent issue of the journal “BMC Women’s Health”, by Dr. Li and associates from Ningbo Women and Children’s Hospital, Ningbo, China.  Currently, laparoscopy with tissue biopsy is the gold standard for the diagnosis of endometriosis in clinical management strategies.  Eutopic and ectopic endometrial tissues (when present), and leucorrhea were…

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Soluble CD90 : a potential serum biomarker in endometriosis

Dr. Bochev and colleagues from several medical centers in Bulgaria published their research on the role of a possible serum biomarker in diagnosing endometriosis in a recent issue of the journal named “Disease Markers”. The definitive diagnosis of endometriosis, an ailment affecting millions of women worldwide currently depends on visual inspection of lesions in laparoscopy and microscopic examination of surgically excised tissues. This diagnostic approach is invasive, may carry risks of postoperative complications, and also it is not easily accessible…

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Immune cells in peritoneal endometriosis

Dr. Burcu Ersoy and associates from The University of Sydney, Australia, published their interesting study on surgically removed peritoneal endometriosis tissues in the journal named "F&S Science". It is still a dilemma how ectopic endometrial tissues attach to the peritoneum, persist and develop. The endometriotic foci show a variation in color due to their age ranging from clear vesicles and red to black and finally scarred white ones. Previous studies did not consider lesion age when assessing the immune cell environment. The…

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Is there a component of "microflora imbalance" in endometriosis?

Dr. Oishi and colleagues from Ryukyus and Mie Universities, Japan, published a prospective cohort study on the microbiota of the female genital tract in the journal "Reproductive Medicine and Biology". Recent studies have found a small number of bacteria in female peritoneal fluids and endometria, but it is unclear how this microbiota may affect human health. Also, the relationship between the microbiota of the female genital tract and endometriosis needs to be clarified. The discovery of a female genital tract…

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Preferential expression of some membrane type matrix metalloproteinase proteins

Dr. Maoga and associates from academic institutions located in Germany and Kenya have published their findings on the immunohistochemical expression of MT-MMP proteins, namely MT2-MMP (MMP15) and MT3-MMP (MMP16) in the eutopic endometrium of healthy and endometriotic patients; and also in adenomyosis and different types of endometriosis, in the journal named Diagnostics. Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases capable of degrading extracellular matrix and are involved in different physiological processes like cell proliferation, differentiation, angiogenesis, apoptosis, and cell migration. These…

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Atherosclerosis is augmented in laboratory mice by experimental endometriosis

Dr. Taylor group from Yale School of Medicine, New Haven, CT, USA has published their experimental study in the "American Journal of Obstetrics & Gynecology" on atherosclerosis following endometriosis induction in laboratory mice. The basic inflammation process in endometriosis patients seems to have systemic consequences and epidemiologic studies point to an increased cardiovascular health risk in women with this ailment. If a casual relationship between endometriosis and atherosclerosis can be shown, this potential complication may be prevented. Under normal conditions, laboratory…

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A novel contribution to patient management in endometriosis by immunohistochemistry

Dr. Tarumi and associates from the Kyoto Prefectural University of Medicine, Kyoto, Japan published their retrospective cohort study on the importance of progesterone receptors on recurring ovarian endometriosis in "The Journal of Clinical Endocrinology & Metabolism". Surgery for endometriosis is applied to a great number of patients and the postoperative recurrence rate of endometriosis is estimated to be from 21.5% up to 56.7% within 2 years of surgery. Unfortunately, recurrence following endometriosis surgery decreases the quality of life and increases pain…

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A revolutionary view on endometriosis related pain

Dr. Lydia Coxon and colleagues from Oxford University, UK, have recently published their cross-sectional study on the categorization of endometriosis-related pain in the journal "Frontiers in Pain Research". As a chronic inflammatory condition, endometriosis results in pelvic pain, dysmenorrhea, and dyspareunia not related to disease burden. In the current research, the prevalence of neuropathic-like pain in endometriosis using a questionnaire screening hypothesizes that endometriosis-associated pain would be classified as neuropathic in some women. Similar to other patients with neuropathic pain these…

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Non-invasive diagnostic tools for endometriosis revisited

Dr. Signorile and associates from the Italian Endometriosis Foundation have published the results of their retrospective study on a large cohort of endometriosis patients in a recent issue of the periodical, In Vivo. Endometriosis lacks precise scientific knowledge and this brings about an incredible underdiagnosis and undertreatment with a long interval of 8-12 years between the beginning of symptoms and the appropriate clinical diagnosis. Currently, there is not any non-invasive diagnostic tool for definitive diagnosis. The final diagnosis of endometriosis is…

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International Working Group's review on endometriosis classification systems

International Endometriosis Working Group including AAGL, ESHRE, ESGE, and WES published a comprehensive review on endometriosis classification, staging, and reporting systems in a recent issue of the journal named "Facts, Views & Vision in Obstetrics and Gynecology". Classification and staging systems have improved clinical management, especially in oncology, rheumatology, and Parkinson’s disease. Following the first suggestion for a classification system for endometriosis in 1973, various publications for endometriosis classification, staging, and reporting systems emerged, but there is still no international…

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An important enigmatic promoter of endometriosis: immune dendritic cells

Dr. Larinha and associates from a Brasilian academic center have published their comprehensive review on the role of immune dendritic cells in the pathogenesis of endometriosis in a recent issue of the "Journal of Reproductive Immunology". Antigen-presenting dendritic cells of the immune system present processed antigens to T cells to mediate between innate and adaptive immunity. Dendritic cells originate from bone marrow progenitors and are a heterogeneous group of immune cells with the ability to migrate from blood to lymphoid and…

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Immunotherapy in endometriosis: a challenging research topic

Dr. Maksym and associates from academic centers in Poland have published their comprehensive review on endometriosis emphasizing the immunological aspects of the disease in a recent issue of the "Journal of Clinical Medicine". Even though endometriosis is a multifactorial disease, it is well known that the appearance of ectopic endometrial implants in the peritoneal cavity is possible due to immunological defects allowing the survival of abnormal tissues which would otherwise be cleared. It is well known that endometriosis is characterized…

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A novel approach to a common lesion: mapping adenomyosis by imaging modalities

Dr. Habiba from Leicester, UK, and Dr. Benagiano from Rome, Italy, have published their overview on adenomyosis in an attempt to set light on a clinically important topic in a recent issue of the "International Journal of Environmental Research and Public Health". The common widely accepted definition of adenomyosis is the presence of endometrium, with both glandular and stromal components, in the uterine muscle layer. There is a wide variation in the incidence rates ranging from 5 to 70%. This…

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Diaphragmatic defects, liver herniations and catamenial pneumothorax

Dr. Arakawa and associates from The Jikei Katsushika Medical Center, Japan, have published their recent case of catamenial pneumothorax with diaphragmatic defect and liver herniation in the "Journal of Cardiothoracic Surgery". Catamenial pneumothorax is an uncommon condition with a reported incidence of less than 3–6% in women with spontaneous pneumothorax. The main clinical features include the repetitive onset of pneumothorax during pre and postmenstrual periods, right-sided onset, and pelvic endometriosis in reproductive age patients.  The patient presented here was a…

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Thoracic endometriosis: the most frequent endometriosis involvement outside abdominopelvic cavity

Six to ten percent of reproductive-age women are affected by endometriosis, and about 12% are estimated to be outside the abdominopelvic cavity - the most frequent location being the thorax. Endometriosis within the pulmonary parenchyma or on the diaphragm and pleural surfaces presents different manifestations, collectively known as thoracic endometriosis syndrome.  Besides classic theories of retrograde menstruation, coelomic metaplasia, lymphatic and hematogeneous dissemination in thoracic endometriosis syndrome, a unique prostaglandin theory is also acceptable, where prostaglandin F2α, a potent constrictor…

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Full understanding the role of nervous system in endometriosis could yield new gateways to novel therapeutic approaches

Dr. Velho and associates from Berlin, Germany have recently published their comprehensive review on the role of the nervous system in endometriosis in a recent issue of “International Journal of Molecular Sciences”. Understanding the role of the peripheral nervous system and its interactions with immune cells will reveal novel pathways and targets in endometriosis that could yield new therapeutic gateways. An increase in the levels of cytokines, chemokines, growth factors, and immune cells enhances the inflammatory environment present in the…

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A rare but important disease: "isolated" endometriosis of the sciatic nerve

Professor Marc Possover from Zurich, Switzerland has published his 16-year experience of surgical laparoscopic interventions on isolated endometriosis of the sciatic nerve in a recent issue of the official publication of the European Society for Gynecological Endoscopy; Facts, Views & Vision in ObGyn. Endometriosis is a problematic disease, both for the patients and physicians but endometriosis of the sciatic nerve (ESN) is even more enigmatic. Cyclical sciatic nerve pain in women may be a clue to potential endometriosis of the…

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The relevance of mitosis in endometriotic tissue biopsies

Dr. Wetzk and co-workers from the Technical University, Dresden, Germany have published a retrospective study on the diagnostic impact of mitotic activity in the endometriotic lesion biopsies in the recent issue of the journal “Geburtshilfe und Frauenheilkunde”. Guidelines highly recommend a microscopic assessment, i.e. sending biopsies to the pathology laboratory after surgical procedures to make a diagnosis of endometriosis precisely. However, the current guidelines do not have clear statements about the specific procedures for this histopathological evaluation. This retrospective study carried…

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A trial of exogenous melatonin on dysmenorrhea in women "without endometriosis"

In their recent article published in “European Journal of Clinical Pharmacology”,  Dr. Söderman and associates from Stockholm report the results of their randomized, double-blind, placebo-controlled trial on the effects of oral melatonin in women with dysmenorrhea -unrelated to endometriosis-. Melatonin is a hormone synthesized, and secreted mainly from the pineal gland in the brain and has pain-relieving effects when administered exogenously. Dysmenorrhea related to endometriosis is treated by non-steroid anti-inflammatory drugs and/or hormonal suppression, both having important complications. In 2013, Schwertner and associates showed…

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Intravascular adenomyomatosis: an important entity to be alert

Pathologists from Stanford University, USA have recently published four novel cases of intravascular adenomyomatosis co-existing with pelvic endometriosis in a recent issue of “Human Pathology”. Intravascular leiomyomatosis is characterized by the presence of smooth muscle in venous and lymphatic spaces of the uterine muscle layer, i.e. myometrium. This invasive intravascular tissue consists of typical smooth muscle. Following the first description of a variant coined as intravascular adenomyomatosis, which is the growth of intravascular smooth muscle also featuring endometrial glands and…

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