Nasuhi Engin Aydin, MD

Nasuhi Engin Aydin,  M.D. a graduate of Hacettepe University Faculty of Medicine, Ankara with E.C.F.M.G. Certification. He started his academic career at Ankara University working on short-term carcinogenicity tests with his research cited in NCI, Bethesda Monograph 65. He has been working as a registered Anatomic Pathologist in Turkey since 1983. Main topics of interest are research on gynecologic pathology besides forensic and surgical pathology with manuscripts published internationally. 

Phytoestrogens could have promising effects in endometriosis management

Dr. Bartiromo and associates from Milan, Italy published a systematic review on phytoestrogens and endometriosis in the periodical “Nutrients”. Endometriosis has features of chronic inflammation based on uncontrolled hormonal response and immune-mediated dysfunctions. Estrogens are endocrine and paracrine agents that could yield adverse effects locally, even with modest variations of estrogen production. From this point, local increase in estradiol and modifications of estrogen receptor expressions in ectopic endometrial tissues may activate a network of cell proliferation genes. Phytoestrogens consist of flavonoids (i.e.,…

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Etiopathogenesis of Endometriosis and Links with Endometrial Cancer

Professor Terzic and colleagues from the Medical School of Nazarbayev University, Kazakhstan published their review on the molecular aspects of endometriosis and endometrial cancer in “International Journal of Molecular Sciences”. The etiopathogenesis of endometriosis has remained controversial, with recent studies suggesting a pelvic inflammatory condition, i.e. “sterile peritonitis”. The peritoneal fluid has an increased concentration of activated macrophages besides an inflammatory profile in the cytokine/chemokine molecular status. There is also further evidence on hormonal and immune factors creating a pro-inflammatory…

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Lead and cadmium exposures of female workers should be reduced as much as possible

Min-Gi Kim and associates from Korea published their results on the possible effects of lead and cadmium exposure in endometriosis induction and severity in a recent issue of “International Journal of Environmental Research and Public Health”. Endometriosis is an illness with multiple causal factors and there is growing evidence on endocrine-disrupting chemicals like dioxin could be involved in the induction and severity of the disease. Trace metals like cadmium, lead, copper, chromium, and mercury have been shown to possess endocrine-disrupting…

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Adenomyosis in adolescents

Dr. Exacoustos and colleagues from two tertiary referral university hospitals in Italy published their results on adenomyosis in adolescent patients in a recent issue of  “The Journal of Minimally Invasive Gynecology”. Adenomyosis is the presence of endometrial glands and stroma in the myometrium that could present as a diffuse or focal manner. It is a well known fact that the prevalence studies yield wide variatons which could be due to different diagnostic classifications, patients’ populations, tissue sample sizes and possible…

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Altered Decidualization and Pregnancy Complications

Dr. Carlo Ticconi and colleagues from Italy published their comprehensive review manuscript “Clinical consequences of defective decidualization” in the June 2021 issue of “Tissue and Cell”. Currently, there has been growing research interest in the study of decidualization, and knowledge of this important biological process has been evolving. Growing evidence supports the concept that an improper decidualization could well be a determinant of several pregnancy complications, both in early and in advanced gestation. This comprehensive review has targeted reviewing the biological…

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Endometrioma post-surgical-recurrence risk factors

Jiang and associates from Dailan Medical University, China published their review manuscript “Risk factors for ovarian endometrioma recurrence following surgical excision: a systematic review and meta‑analysis” in the June 2021 issue of "Archives of Gynecology and Obstetrics". The most common form of endometriosis, "ovarian endometrioma" has an estimated prevalence of 17% -44% among endometriosis patients. Surgery is the standard treatment for endometrioma, but there is a risk of recurrence about 21.5% after 2 years and 40–50% after 5-years follow-up. Recurrences after OMA surgeries result in…

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The clues for pain and infertility in endometriosis/adenomyosis complex

Drs. Gruber and Mechsner from Charite University-Berlin, Germany published their comprehensive review on pathophysiological background of endometriosis and adenomyosis in the scientific periodical “Cells”. Chronic pain and fertility problems are the main clinical issue in endometriosis and adenomyosis patients. In order to overcome these problems, it is of utmost important to understand the pathophysiologic basis of these lesions as well as their effect on the surrounding tissues. The treatment needs qualified clinicians since abdominal and gynecological surgery could be necessary in the clinical…

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Promising therapeutic results in experimental endometriosis model

Tiziana Genovese and associates from Italian academic centers reported their pioneering findings in an experimental model of endometriosis administering an anti-tumor agent and glucocorticoid combination, published in the scientific periodical “International Journal of Molecular Sciences”. Endometriosis is a worldwide common disease without a clear-cut treatment modality as yet. The pathogenesis is still not verified precisely, but investigators agree that cellular proliferation, apoptosis and chronic inflammation all have important roles in its pathophysiology.  Fotemustine is an antitumor agent belonging to the widely…

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Resveratrol, isoflavones and puerarin have favorable in vivo results in endometriosis studies

Xia Cai and associates from research units located in China published their review article on the relationship between phytoestrogens and endometriosis in the scientific periodical named “Pharmacology”. The great variation in the prevalence of endometriosis raises questions in regard to lifestyle, effects of certain environmental factors besides genetic vulnerability. Phytoestrogens affect estrogen-mediated responses by binding to estrogen receptors. Laboratory studies and epidemiological observations have been performed to reveal the causal relationship between phytoestrogens and endometriosis. Phytoestrogens may regulate the expression of key…

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Does hyaluronic acid have a role in endometriosis?

Pei-Hsiu Yu and associates from Tainan, Taiwan, published their results of original research on the role of hyaluronic acid in endometriosis formation in a recent issue of  "Taiwanese Journal of Obstetrics and Gynecology". Hyaluronic acid, a glycosaminoglycan protein in the extracellular matrix, is a useful anti-adhesive agent applied after laparoscopic surgery for endometriosis. Hyaluronic acid functions like hyaline cartilage protection in clinical use and anti-inflammatory effect on reducing proinflammatory cytokines. Exogenous hyaluronic acid is a useful anti-adhesive agent in preventing…

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A hot research topic: macrophage reprogramming for endometriosis treatment

 Daria Artemova and colleagues from several research institutes of the Russian Federation have published their review on the cellular aspects of endometriosis related to macrophages, particularly emphasizing  promising therapeutic options for the future in "International Journal of Molecular Sciences". Macrophages have important roles in natural immunity and are dispersed throughout the body. These cellular components of the “innate immunity” may either support or counteract inflammation, depending on the signals received. Neoplasia and endometriosis have much in common, especially cellular viability in…

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New molecular insights in endometriosis pathogenesis

Dr. Rosalba Siracusa and associates from Messina University, Italy, have published their research on cellular pathogenesis of experimental endometriotic lesions in the recent issue of the "International Journal of  Molecular Sciences". Endometriosis is a debilitating chronic estrogen-dependent inflammatory condition and it is the third cause of hospitalization in the USA. There are several published molecular research papers that show alterations in autophagy and mitophagy in endometriosis pathogenesis. In particular, altered autophagic flux induces changes in cellular survival, and it has been demonstrated…

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Combined contraceptive pills and immune system cells in the endometriotic cyst wall

Dr. Wanwisa Waiyaput and associates from Mahidol University, Bangkok, Thailand, have published their results on the immune regulatory cells of the surgically resected endometriotic cyst walls in the “Journal of Ovarian Research”. The defective immune response is believed to have a major impact on the pathogenesis of endometriosis besides coelomic metaplasia, Mullerian rests, lymphatic and hematogenous spread, and differentiated stem cells, and “retrograde menstruation” theories. Although the exact cause of endometriosis is unknown, it is an estrogen-dependent disorder making combined…

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Retinol-binding protein in endometriosis pathogenesis

Dr. Jae Chul Lee and associates from the Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, have published the recent results of their research on endometriosis regarding the role of retinol-binding protein4 (RBP4) in the "International Journal of  Molecular Sciences".  Endometriosis appears to affect 5–10% of the women of reproductive age, but about 80% of the women with pelvic pain, and 20–50% of the women with infertility suffer from this chronic illness. A…

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The need for the standardization of diagnostic protocols for "adenomyosis"

Dr. Squillace and associates from Brasilian Academic and Health Centers published their paper titled “Adenomyosis and in vitro fertilization impacts- a literature review” in a recent issue of "JBRA Assisted Reproduction". As common gynecological ailment adenomyosis frequently coexists with endometriosis. Though there seems to be a causal relationship between adenomyosis and infertility how adenomyosis could affect reproductive outcomes adversely is not fully understood. Most women with adenomyosis face the real impact of this condition during the management of infertility management and…

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Endometriosis from the "EVOLUTIONARY" point of view

Natalie Dinsdale and associates from the Canadian Simon Fraser University Department of Biological Sciences published a critical review titled “ The evolutionary biology of endometriosis” in a recent issue of the journal “Evolution, medicine and public health”. This review focuses on the evolutionary and mechanistic bases for the risk of endometriosis in humans searching for answers to four questions about phenotypes: phylogenetic history, development, mechanism, and adaptive significance.  Endometriosis is defined as the proliferation of endometrial tissue outside of the uterus, ectopia,…

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Promising potential research topic: diagnostic biomarkers for endometriosis

Dr. Toczek and collegues from the Department of Gynecology, Obstetrics and Oncological Gynecology of Medical University of Silesia in Katowice, Poland, have  published a review paper on possible diagnostic aid of cytokines in endometriosis. This review appears in May issue of the scientific journal named "International Journal of Environmental Research and Public Health". Endometriosis is a common condition, a chronic and progressive disease compromising social relationships, sexuality, and mental health of the patients.  The inflammatory and immune response, along with…

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Myeloid-Derived Suppressor Cells are gaining importance in endometriosis

Dr. Wertel and associates from Polish academic centers published their sentimental review paper on the role of "Myeloid-Derived Suppressor Cells" in human diseases, in a recent issue of  Cells. Endometriosis, the most common gynecological disease affecting about 10% of women globally, is now classified as a tumor-like lesion. In this regard, ectopic endometrial tissues outside the uterus have similarities to those of ovarian cancers with their potential of invasion, new vessel formation called neoangiogenesis, reduced cell death, and local inflammation. Research…

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Endometrial epithelial stem/progenitor cells have links to endometriosis with potential therapeutic research aspects

Dr. Cousins with colleagues from Australia and the USA published their review paper on a not well-known subject, the epithelial stem/progenitor cells of the endometrium. This interesting paper is recently published in the scientific journal named "Frontiers in Cell and Developmental Biology". Endometrial tissue has the property of going through continuous cycles of proliferation, differentiation, breakdown, shedding, and repair under the homeostatic control mechanisms of fluctuating circulating ovarian hormones. The endometrium of the mouse uterus consists of luminal epithelium and glandular epithelium,…

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Endometriosis and susceptibility to COVID-19

Dr. Moazzami and associates from Pars Advanced and Minimally Invasive Medical Manners Research Center, Tehran, Iran have published their results on COVID-19 in endometriosis patients in the medical journal named "BMC’s Women’s Health". COVID-19 is still an emerging critical global health problem with plenty of research studying the associated factors. It is not clear whether endometriosis increases the risk of COVID-19. Being an inflammatory disease, endometriosis may risk the patients being more susceptible to COVID-19. If this is the case, more specific…

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