Nasuhi Engin Aydin, MD

Nasuhi Engin Aydin,  M.D. a graduate of Hacettepe University Faculty of Medicine, Ankara with E.C.F.M.G. Certification. He started his academic career at Ankara University working on short-term carcinogenicity tests with his research cited in NCI, Bethesda Monograph 65. He has been working as a registered Anatomic Pathologist in Turkey since 1983. Main topics of interest are research on gynecologic pathology besides forensic and surgical pathology with manuscripts published internationally. 

Combined contraceptive pills and immune system cells in the endometriotic cyst wall

Dr. Wanwisa Waiyaput and associates from Mahidol University, Bangkok, Thailand, have published their results on the immune regulatory cells of the surgically resected endometriotic cyst walls in the “Journal of Ovarian Research”. The defective immune response is believed to have a major impact on the pathogenesis of endometriosis besides coelomic metaplasia, Mullerian rests, lymphatic and hematogenous spread, and differentiated stem cells, and “retrograde menstruation” theories. Although the exact cause of endometriosis is unknown, it is an estrogen-dependent disorder making combined…

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Retinol-binding protein in endometriosis pathogenesis

Dr. Jae Chul Lee and associates from the Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, have published the recent results of their research on endometriosis regarding the role of retinol-binding protein4 (RBP4) in the "International Journal of  Molecular Sciences".  Endometriosis appears to affect 5–10% of the women of reproductive age, but about 80% of the women with pelvic pain, and 20–50% of the women with infertility suffer from this chronic illness. A…

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The need for the standardization of diagnostic protocols for "adenomyosis"

Dr. Squillace and associates from Brasilian Academic and Health Centers published their paper titled “Adenomyosis and in vitro fertilization impacts- a literature review” in a recent issue of "JBRA Assisted Reproduction". As common gynecological ailment adenomyosis frequently coexists with endometriosis. Though there seems to be a causal relationship between adenomyosis and infertility how adenomyosis could affect reproductive outcomes adversely is not fully understood. Most women with adenomyosis face the real impact of this condition during the management of infertility management and…

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Endometriosis from the "EVOLUTIONARY" point of view

Natalie Dinsdale and associates from the Canadian Simon Fraser University Department of Biological Sciences published a critical review titled “ The evolutionary biology of endometriosis” in a recent issue of the journal “Evolution, medicine and public health”. This review focuses on the evolutionary and mechanistic bases for the risk of endometriosis in humans searching for answers to four questions about phenotypes: phylogenetic history, development, mechanism, and adaptive significance.  Endometriosis is defined as the proliferation of endometrial tissue outside of the uterus, ectopia,…

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Promising potential research topic: diagnostic biomarkers for endometriosis

Dr. Toczek and collegues from the Department of Gynecology, Obstetrics and Oncological Gynecology of Medical University of Silesia in Katowice, Poland, have  published a review paper on possible diagnostic aid of cytokines in endometriosis. This review appears in May issue of the scientific journal named "International Journal of Environmental Research and Public Health". Endometriosis is a common condition, a chronic and progressive disease compromising social relationships, sexuality, and mental health of the patients.  The inflammatory and immune response, along with…

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Myeloid-Derived Suppressor Cells are gaining importance in endometriosis

Dr. Wertel and associates from Polish academic centers published their sentimental review paper on the role of "Myeloid-Derived Suppressor Cells" in human diseases, in a recent issue of  Cells. Endometriosis, the most common gynecological disease affecting about 10% of women globally, is now classified as a tumor-like lesion. In this regard, ectopic endometrial tissues outside the uterus have similarities to those of ovarian cancers with their potential of invasion, new vessel formation called neoangiogenesis, reduced cell death, and local inflammation. Research…

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Endometrial epithelial stem/progenitor cells have links to endometriosis with potential therapeutic research aspects

Dr. Cousins with colleagues from Australia and the USA published their review paper on a not well-known subject, the epithelial stem/progenitor cells of the endometrium. This interesting paper is recently published in the scientific journal named "Frontiers in Cell and Developmental Biology". Endometrial tissue has the property of going through continuous cycles of proliferation, differentiation, breakdown, shedding, and repair under the homeostatic control mechanisms of fluctuating circulating ovarian hormones. The endometrium of the mouse uterus consists of luminal epithelium and glandular epithelium,…

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Endometriosis and susceptibility to COVID-19

Dr. Moazzami and associates from Pars Advanced and Minimally Invasive Medical Manners Research Center, Tehran, Iran have published their results on COVID-19 in endometriosis patients in the medical journal named "BMC’s Women’s Health". COVID-19 is still an emerging critical global health problem with plenty of research studying the associated factors. It is not clear whether endometriosis increases the risk of COVID-19. Being an inflammatory disease, endometriosis may risk the patients being more susceptible to COVID-19. If this is the case, more specific…

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Adenomyosis: accuracy of the diagnostic methods and the synchronism with deep infiltrating endometriosis

Dr. Alborzi and associates from Shiraz University of Medical Sciences, Iran, have published their comprehensive retrospective research conducted on 3725 patients with clinical symptoms of endometriosis over a period of 3 years, in "Reproductive Sciences" medical journal.  A relationship between endometriosis and adenomyosis has been suggested for years. Common pathophysiology for their simultaneous presence in the pelvis was sought in scientific papers. Adenomyosis basically is defined as the presence of endometrial glands and stroma within the myometrium which also involves…

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Diaphragmatic defects, liver herniations and catamenial pneumothorax

Dr. Arakawa and associates from The Jikei Katsushika Medical Center, Japan, have published their recent case of catamenial pneumothorax with diaphragmatic defect and liver herniation in the "Journal of Cardiothoracic Surgery". Catamenial pneumothorax is an uncommon condition with a reported incidence of less than 3–6% in women with spontaneous pneumothorax. The main clinical features include repetitive onset of pneumothorax during pre and postmenstrual  periods, right-sided onset, and pelvic endometriosis in reproductive age patients.  The patient presented here was a 43-year-old…

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Current research on adenomyosis tissues with immunohistochemistry reveal novel findings

Dr. Xiaofang Xu and associates from Fudan University, China have recently published their research on adenomyosis-related research results in "Reproductive Biology and Endocrinology". Adenomyosis is a benign gynecological condition, prevalent worldwide that is characterized by the presence of ectopic endometrial tissues in the myometrium. Dysmenorrhea is the most common symptom besides abnormal uterine bleeding. Scientific findings indicate that adenomyotic lesions, similar to endometriotic lesions, are wounds undergoing repeated tissue injury and repair (ReTIAR) due to cyclic bleeding of ectopic endometria.  In this setting,…

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Endometrial receptivity after the removal of ovarian endometriotic cysts

Mikhaleva and associates from the "Russian Research Institute of Human Morphology" published their results in “Reproductive Sciences” yielding their novel morphological findings of eutopic endometria in patients following surgical excision of endometriotic ovarian cysts. Current therapeutic measures are targeting to relieve symptoms related to endometriosis as a fundamental goal. There is a need for further scientific elucidation of endometriosis-related patho-morphology. Infertility is an important aspect of endometriosis that seems to be mainly due to subtle changes in endometrial capacity for…

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Oxygen deprivation (hypoxia) has a critical role in the pathogenesis and progression of endometriosis

Dr. Wan-Ning Li and associates from academic institutions from Taiwan have published their review paper on the role of hypoxia and possible therapeutic outcomes in the medical journal named "Reproduction" recently.  Endometriosis is an important ailment with huge medical and social impact that remains elusive in regard to its pathogenesis. The development of endometriosis seems to be related to the interactions of multiple gene–gene and gene–microenvironmental factors. Hypoxia-inducible factors (HIFs), a group of heterodimeric molecules with α and β subunits, are…

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A comparison of symptomatology and histopathologic features in surgically resected colorectal endometriosis

Dr. Tschan and associates from Feldrich Academic Teaching Hospital, Austria published their retrospective research on patients requiring colorectal surgical resection for endometriosis in European Journal of Medical Research. Bowel endometriosis requiring colorectal surgical resection causes important morbidity. The rectum and sigmoid colon are the most frequent involvement around 90% of intestinal endometriosis cases. Most of the patients experience diminished quality of life due to pain, infertility, and repeated operations besides possible long-term medical therapy. The histopathological features of endometriosis lesions…

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"Speckle sign": a novel transvaginal ultrasound finding for posterior compartment endometriosis

Dr. Balcacer and associates from three medical institutions located in the USA report the results of their retrospective study on deep infiltrating endometriosis utilizing transvaginal ultrasound examination and the proposed  “speckle sign” in the "Journal of Ultrasound Medicine". Pelvic ultrasound is routinely used mainly for the diagnostic workup of endometriosis but deep infiltrating endometriosis may cause diagnostic challenges due to common atypical presentations. This study focused on defining a meaningful sign in patients with deep invasive endometriosis where the authors…

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Time for noninvasive serum markers for endometriosis diagnosis

Dr. Onur Guralp and associates from Germany and Turkey published their results on serum markers predicting endometriosis in the "Journal of Obstetrics and Gynaecology".   Still, in 21st-century medicine, doctors can not diagnose endometriosis using biochemical serum markers. Proposed serum markers suggested for this purpose such as CA125 and others have been so far not effective in this regard. In this study researchers aimed to find the diagnostic value of a panel consisting of CA125, endocan, YKL-40, and copeptin for the…

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Separation of epithelia and stroma components in endometriosis lesions yields remarkable molecular points - Ie-Ming Shih, MD, Ph.D.

The pathologies of adenomyosis and endometriosis are unique among non-malignant gynecological diseases and provide fertile research topics. Ectopic endometrial tissues may have distinct molecular changes distinct from eutopic endometria despite having similar morphology. In this regard, there are intriguing suggestions as peritoneal endometriosis and adenomyosis seem to be molecularly related. Research made on molecular aspects of eutopic and ectopic endometrium by separating epithelia from stroma has been rewarding. Whole-exome sequencing besides global methylation profiles utilizing this separation technique by laser-capture microdissection was…

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It is time for redefining endometriosis with our contemporary scientific knowledge - Philippe Koninckx, MD, Ph.D.

Endometriosis defined as endometrium-like tissue outside the uterus has a poorly understood natural history. It is a heterogeneous disease having genetic-epigenetic features with many biochemical changes in the lesions. The Sampson hypothesis of implanted endometrial cells following retrograde menstruation is not able to explain all observations. The property of genetic- and epigenetic features transmitted at birth may explain the hereditary aspects, the predisposition, and the endometriosis-associated changes in the endometrium, immunology, and placentation. However, the pathogenesis of cystic ovarian or deep…

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How to unveil the discrepancy regarding the effect of chemicals on the etiology of endometriosis

Kristen Upson from Michigan State University published a review article evaluating research papers on environmental factors effective in endometriosis from an epidemiological perspective in "Current Epidemiology Reports". Endometriosis is a multifactorial disease with anatomical, hormonal, immunological, estrogenic, genetic, epigenetic, and environmental factors operating. Exogenous chemicals, interfering with any aspect of the hormonal milieu (endocrine-disrupting chemicals) are suspected in yielding a risk in endometriosis. The list of environmental chemicals suspected having a role in endometriosis expanded tremendously and includes perfluoroalkyl substances,…

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Endometriosis and adenomyosis could be the “sides of the same coin”.

The two common gynecological disorders, namely adenomyosis, and endometriosis are not settled yet, whether they are representing two different entities or different phenotypes of the same ailment. Dr. Maruyama and colleagues from Nara, Japan searched PubMed and Google Scholar electronic databases published between January 2000 and April 2020 for keywords ‘adenomyosis’, ‘endometriosis’, ‘pathogenesis’, ‘classification’, ‘subtype’, ‘phenotype’, and ‘fibrosis’. The results of this search were published in the "European Journal of Obstetrics & Gynecology and Reproductive Biology" recently. Endometriosis has three…

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