Nasuhi Engin Aydin, MD

Nasuhi Engin Aydin,  M.D. a graduate of Hacettepe University Faculty of Medicine, Ankara with E.C.F.M.G. Certification. He started his academic career at Ankara University working on short-term carcinogenicity tests with his research cited in NCI, Bethesda Monograph 65. He has been working as a registered Anatomic Pathologist in Turkey since 1983. Main topics of interest are research on gynecologic pathology besides forensic and surgical pathology with manuscripts published internationally. 

The clues for pain and infertility in endometriosis/adenomyosis complex

Drs. Gruber and Mechsner from Charite University-Berlin, Germany published their comprehensive review on pathophysiological background of endometriosis and adenomyosis in the scientific periodical “Cells”. Chronic pain and fertility problems are the main clinical issue in endometriosis and adenomyosis patients. In order to overcome these problems, it is of utmost important to understand the pathophysiologic basis of these lesions as well as their effect on the surrounding tissues. The treatment needs qualified clinicians since abdominal and gynecological surgery could be necessary in the clinical…

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Promising therapeutic results in experimental endometriosis model

Tiziana Genovese and associates from Italian academic centers reported their pioneering findings in an experimental model of endometriosis administering an anti-tumor agent and glucocorticoid combination, published in the scientific periodical “International Journal of Molecular Sciences”. Endometriosis is a worldwide common disease without a clear-cut treatment modality as yet. The pathogenesis is still not verified precisely, but investigators agree that cellular proliferation, apoptosis and chronic inflammation all have important roles in its pathophysiology.  Fotemustine is an antitumor agent belonging to the widely…

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Resveratrol, isoflavones and puerarin have favorable in vivo results in endometriosis studies

Xia Cai and associates from research units located in China published their review article on the relationship between phytoestrogens and endometriosis in the scientific periodical named “Pharmacology”. The great variation in the prevalence of endometriosis raises questions in regard to lifestyle, effects of certain environmental factors besides genetic vulnerability. Phytoestrogens affect estrogen-mediated responses by binding to estrogen receptors. Laboratory studies and epidemiological observations have been performed to reveal the causal relationship between phytoestrogens and endometriosis. Phytoestrogens may regulate the expression of key…

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Does hyaluronic acid have a role in endometriosis?

Pei-Hsiu Yu and associates from Tainan, Taiwan, published their results of original research on the role of hyaluronic acid in endometriosis formation in a recent issue of  "Taiwanese Journal of Obstetrics and Gynecology". Hyaluronic acid, a glycosaminoglycan protein in the extracellular matrix, is a useful anti-adhesive agent applied after laparoscopic surgery for endometriosis. Hyaluronic acid functions like hyaline cartilage protection in clinical use and anti-inflammatory effect on reducing proinflammatory cytokines. Exogenous hyaluronic acid is a useful anti-adhesive agent in preventing…

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A hot research topic: macrophage reprogramming for endometriosis treatment

 Daria Artemova and colleagues from several research institutes of the Russian Federation have published their review on the cellular aspects of endometriosis related to macrophages, particularly emphasizing  promising therapeutic options for the future in "International Journal of Molecular Sciences". Macrophages have important roles in natural immunity and are dispersed throughout the body. These cellular components of the “innate immunity” may either support or counteract inflammation, depending on the signals received. Neoplasia and endometriosis have much in common, especially cellular viability in…

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New molecular insights in endometriosis pathogenesis

Dr. Rosalba Siracusa and associates from Messina University, Italy, have published their research on cellular pathogenesis of experimental endometriotic lesions in the recent issue of the "International Journal of  Molecular Sciences". Endometriosis is a debilitating chronic estrogen-dependent inflammatory condition and it is the third cause of hospitalization in the USA. There are several published molecular research papers that show alterations in autophagy and mitophagy in endometriosis pathogenesis. In particular, altered autophagic flux induces changes in cellular survival, and it has been demonstrated…

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Combined contraceptive pills and immune system cells in the endometriotic cyst wall

Dr. Wanwisa Waiyaput and associates from Mahidol University, Bangkok, Thailand, have published their results on the immune regulatory cells of the surgically resected endometriotic cyst walls in the “Journal of Ovarian Research”. The defective immune response is believed to have a major impact on the pathogenesis of endometriosis besides coelomic metaplasia, Mullerian rests, lymphatic and hematogenous spread, and differentiated stem cells, and “retrograde menstruation” theories. Although the exact cause of endometriosis is unknown, it is an estrogen-dependent disorder making combined…

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Retinol-binding protein in endometriosis pathogenesis

Dr. Jae Chul Lee and associates from the Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, have published the recent results of their research on endometriosis regarding the role of retinol-binding protein4 (RBP4) in the "International Journal of  Molecular Sciences".  Endometriosis appears to affect 5–10% of the women of reproductive age, but about 80% of the women with pelvic pain, and 20–50% of the women with infertility suffer from this chronic illness. A…

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The need for the standardization of diagnostic protocols for "adenomyosis"

Dr. Squillace and associates from Brasilian Academic and Health Centers published their paper titled “Adenomyosis and in vitro fertilization impacts- a literature review” in a recent issue of "JBRA Assisted Reproduction". As common gynecological ailment adenomyosis frequently coexists with endometriosis. Though there seems to be a causal relationship between adenomyosis and infertility how adenomyosis could affect reproductive outcomes adversely is not fully understood. Most women with adenomyosis face the real impact of this condition during the management of infertility management and…

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Endometriosis from the "EVOLUTIONARY" point of view

Natalie Dinsdale and associates from the Canadian Simon Fraser University Department of Biological Sciences published a critical review titled “ The evolutionary biology of endometriosis” in a recent issue of the journal “Evolution, medicine and public health”. This review focuses on the evolutionary and mechanistic bases for the risk of endometriosis in humans searching for answers to four questions about phenotypes: phylogenetic history, development, mechanism, and adaptive significance.  Endometriosis is defined as the proliferation of endometrial tissue outside of the uterus, ectopia,…

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Promising potential research topic: diagnostic biomarkers for endometriosis

Dr. Toczek and collegues from the Department of Gynecology, Obstetrics and Oncological Gynecology of Medical University of Silesia in Katowice, Poland, have  published a review paper on possible diagnostic aid of cytokines in endometriosis. This review appears in May issue of the scientific journal named "International Journal of Environmental Research and Public Health". Endometriosis is a common condition, a chronic and progressive disease compromising social relationships, sexuality, and mental health of the patients.  The inflammatory and immune response, along with…

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Myeloid-Derived Suppressor Cells are gaining importance in endometriosis

Dr. Wertel and associates from Polish academic centers published their sentimental review paper on the role of "Myeloid-Derived Suppressor Cells" in human diseases, in a recent issue of  Cells. Endometriosis, the most common gynecological disease affecting about 10% of women globally, is now classified as a tumor-like lesion. In this regard, ectopic endometrial tissues outside the uterus have similarities to those of ovarian cancers with their potential of invasion, new vessel formation called neoangiogenesis, reduced cell death, and local inflammation. Research…

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Endometrial epithelial stem/progenitor cells have links to endometriosis with potential therapeutic research aspects

Dr. Cousins with colleagues from Australia and the USA published their review paper on a not well-known subject, the epithelial stem/progenitor cells of the endometrium. This interesting paper is recently published in the scientific journal named "Frontiers in Cell and Developmental Biology". Endometrial tissue has the property of going through continuous cycles of proliferation, differentiation, breakdown, shedding, and repair under the homeostatic control mechanisms of fluctuating circulating ovarian hormones. The endometrium of the mouse uterus consists of luminal epithelium and glandular epithelium,…

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Endometriosis and susceptibility to COVID-19

Dr. Moazzami and associates from Pars Advanced and Minimally Invasive Medical Manners Research Center, Tehran, Iran have published their results on COVID-19 in endometriosis patients in the medical journal named "BMC’s Women’s Health". COVID-19 is still an emerging critical global health problem with plenty of research studying the associated factors. It is not clear whether endometriosis increases the risk of COVID-19. Being an inflammatory disease, endometriosis may risk the patients being more susceptible to COVID-19. If this is the case, more specific…

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Adenomyosis: accuracy of the diagnostic methods and the synchronism with deep infiltrating endometriosis

Dr. Alborzi and associates from Shiraz University of Medical Sciences, Iran, have published their comprehensive retrospective research conducted on 3725 patients with clinical symptoms of endometriosis over a period of 3 years, in "Reproductive Sciences" medical journal.  A relationship between endometriosis and adenomyosis has been suggested for years. Common pathophysiology for their simultaneous presence in the pelvis was sought in scientific papers. Adenomyosis basically is defined as the presence of endometrial glands and stroma within the myometrium which also involves…

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Diaphragmatic defects, liver herniations and catamenial pneumothorax

Dr. Arakawa and associates from The Jikei Katsushika Medical Center, Japan, have published their recent case of catamenial pneumothorax with diaphragmatic defect and liver herniation in the "Journal of Cardiothoracic Surgery". Catamenial pneumothorax is an uncommon condition with a reported incidence of less than 3–6% in women with spontaneous pneumothorax. The main clinical features include repetitive onset of pneumothorax during pre and postmenstrual  periods, right-sided onset, and pelvic endometriosis in reproductive age patients.  The patient presented here was a 43-year-old…

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Current research on adenomyosis tissues with immunohistochemistry reveal novel findings

Dr. Xiaofang Xu and associates from Fudan University, China have recently published their research on adenomyosis-related research results in "Reproductive Biology and Endocrinology". Adenomyosis is a benign gynecological condition, prevalent worldwide that is characterized by the presence of ectopic endometrial tissues in the myometrium. Dysmenorrhea is the most common symptom besides abnormal uterine bleeding. Scientific findings indicate that adenomyotic lesions, similar to endometriotic lesions, are wounds undergoing repeated tissue injury and repair (ReTIAR) due to cyclic bleeding of ectopic endometria.  In this setting,…

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Endometrial receptivity after the removal of ovarian endometriotic cysts

Mikhaleva and associates from the "Russian Research Institute of Human Morphology" published their results in “Reproductive Sciences” yielding their novel morphological findings of eutopic endometria in patients following surgical excision of endometriotic ovarian cysts. Current therapeutic measures are targeting to relieve symptoms related to endometriosis as a fundamental goal. There is a need for further scientific elucidation of endometriosis-related patho-morphology. Infertility is an important aspect of endometriosis that seems to be mainly due to subtle changes in endometrial capacity for…

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Oxygen deprivation (hypoxia) has a critical role in the pathogenesis and progression of endometriosis

Dr. Wan-Ning Li and associates from academic institutions from Taiwan have published their review paper on the role of hypoxia and possible therapeutic outcomes in the medical journal named "Reproduction" recently.  Endometriosis is an important ailment with huge medical and social impact that remains elusive in regard to its pathogenesis. The development of endometriosis seems to be related to the interactions of multiple gene–gene and gene–microenvironmental factors. Hypoxia-inducible factors (HIFs), a group of heterodimeric molecules with α and β subunits, are…

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A comparison of symptomatology and histopathologic features in surgically resected colorectal endometriosis

Dr. Tschan and associates from Feldrich Academic Teaching Hospital, Austria published their retrospective research on patients requiring colorectal surgical resection for endometriosis in European Journal of Medical Research. Bowel endometriosis requiring colorectal surgical resection causes important morbidity. The rectum and sigmoid colon are the most frequent involvement around 90% of intestinal endometriosis cases. Most of the patients experience diminished quality of life due to pain, infertility, and repeated operations besides possible long-term medical therapy. The histopathological features of endometriosis lesions…

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