Nasuhi Engin Aydin, MD
Nasuhi Engin Aydin, MD is a graduate of Hacettepe University Faculty of Medicine, Ankara with ECFMG Certification. He started his academic career at Ankara University working on short-term carcinogenicity tests, supported by TUBITAK grant with his research cited in NCI, Bethesda Monograph 65. He has been working as a licensed Anatomic Pathologist in Turkey since 1983. Main topics of interest are anatomic and surgical pathology with published manuscripts mainly in gynecopath and forensics.(Web of Science ResearcherID O-90432016 H-Index 20 as of 12/2022)
https://www.youtube.com/watch?v=cNq6VTWVk80
Reviewing all you want to know on endometriosis !
Academicians from the International University of Sarajevo, Bosnia, and Lincoln Medical School, UK have written a comprehensive updated review on endometriosis covering many aspects of endometriosis and published their paper as an open-access manuscript in the journal “Pathology-Research and Practice”. Endometriosis affects around 6–10% of reproductive-age women all over the world, causing debilitating pain, heavy menstrual bleeding, pain during sexual intercourse, and infertility. The etiology has not been fully revealed yet. However, it is generally accepted that the endometriotic lesions…
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Asia-Pacific: Expert panel's suggestions for improving endometriosis-related health issues
"Endometriosis should be diagnosed as early as possible for the sake of the patients" and the Asia-Pacific Endometriosis Expert Panel sought to address the reasons for diagnostic delays in this part of the world and published a consensus report in a recent issue of the "International Journal of Gynecology and Obstetrics". It is a widely known scientific reality that Asian women have relatively high rates of endometriosis when compared to white female populations elsewhere. 60% of the total world population is…
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Endometriosis in Asia
Academicians from the University of Philippines led by Dr. Velarde have published a recent review on endometriosis and Asian women in the scientific periodical “Endocrine Connections”. The endometriosis prevalence rate is variable among ethnicities, and Asian women including Filipinos, Indians, Japanese, and Koreans are more likely to be diagnosed with endometriosis compared to Caucasian women with an odds ratio of 1.63. In spite of the high rates of endometriosis in Asians, data on endometriosis and funding support for research are still highly…
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Vicious cycle: The promoting role of previous endometriosis foci for new lesions
An experimental animal study on the pathogenesis of endometriosis from the Institute for Clinical and Experimental Surgery, Saarland University, Hamburg has been published in a recent issue of International Journal of Molecular Sciences. Endometriosis is a well-known common gynecological ailment characterized by endometrial tissues located ectopically. Most patients have endometriotic lesions on intraabdominal peritoneal surfaces. The most popular pathogenetic postulation for endometriosis is the retrograde transfer of eutopic endometria through Fallopian tubes into the abdomen and adherence to the peritoneal…
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Omitted facet of endometriosis : mental health related to stigma
A team of clinical psychologists involved in women’s health led by Deniz Kocas has published a recent review on the mental health aspect of endometriosis patients in the European Journal of Obstetrics & Gynecology and Reproductive Biology. Endometriosis is a notoriously complex disease through not well-understood pathogenesis along with multifaceted presentations in patients leading to complicated issues in women’s health worldwide. "Stigma", defined as an “attribute that is deeply discrediting”, also affects the psychosocial milieu of endometriosis patients widely. Stigma sets…
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A pioneering study on clinicopathologic features of biopsies of endometriotic lesions
Deep infiltrating endometriosis, where endometriotic lesions have an invasion depth of ≥5mm to the underlying tissues, is well known due to the troublesome features, peritoneal endometriosis is very common and widely distributed by superficial involvement in the pelvic visceral and mural peritoneal tissues. Dr. Qiu and associates investigated the clinical and histopathological features of peritoneal endometriosis and deep infiltrating endometriosis in a total of 100 patients with endometriosis treated at Dalian Women and Children’s Hospital/Dalian Women and Children’s Medical…
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Toxic metal cadmium and Endometriosis
Data analyst Mandy Hall and and colleagues from the Department of Epidemiology and Biostatistics, Michigan State University, USA, have published their results on cadmium levels and endometriosis in a recent issue of “Human Reproduction”. In 2020 the World Health Organization placed cadmium in the top 10 chemicals of public health concern. Cadmium released from industrial sources to the environment is absorbed by plants, including tobacco, leafy vegetables, root vegetables, grains, soybeans, and by aquatic organisms, such as shellfish. Moreover, cigarette…
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Review of neutrophil based scientific research in endometriosis
Xinlei Wang and associates from Jilin University, Changchun, China, have published a comprehensive review on the pathogenetic role of neutrophils in endometriosis in a recent issue of the periodical “Mediators of inflammation”. As a common inflammatory condition where endometrial tissue exists outside the uterine cavity, endometriosis is now widely acknowledged as a final consequence of immune dysfunction. The most widely accepted classical endometriosis theory is retrograde menstruation but although a great number of women have this retrograde menstruation only a fraction…
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The public plea of international group of "endometriosis experts"
A group of international “endometriosis experts” led by Professor Philippe R. Koninckx from Belgium, have published their unique scientific paper “The 10 “Cardinal Sins” in the Clinical Diagnosis and Treatment of Endometriosis: A Bayesian Approach” in a recent issue of Journal of Clinical Medicine. As accepted in all clinical issues, the diagnosis and treatment of endometriosis should be based on the best clues available and evidence-based medicine emphasizes avoiding allocation, patient or observer bias, and (traditional) statistical validation. Evidence-based medicine has…
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Ovarian cancers arising in endometriosis: still an unresolved issue
Alice Bergamini and associates from San Raffaele Scientific Institute, Milan, Italy have published their results on clinicopathologic features of endometriosis-associated ovarian cancers in a recent issue of the journal “Diagnostics”. The association between endometriosis and ovarian cancer was first noticed in 1925 by Sampson, and then, confirmed by Scott in 1953, following observation of benign endometriosis in proximity to ovarian cancer. Scientific studies confirmed that the epithelial ovarian cancers that are most closely related to endometriosis are endometrioid and clear cell…
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Adenomyosis and infertility: Does immunology mapping help?
Professor Dr. Wolfgang Küpker (MD, PhD), Medical Director and CEO of IVF Baden Baden at the University of Schleswig Holstein in Lübeck delivered a conference at the Annual International Medical Conference of the Endometriosis Foundation of America held in New York on April 1-2, 2023. Adenomyosis was first described by Pathologist Rokitansky in the 19th century, nowadays it also has clinical implications in regard to pregnancy issues. It is now well known that endometriosis and adenomyosis both have activating mutations of KRAS and…
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Endometriosis disease modelling via induced pluripotent stem cells has been successful
J. Julie Kim, S. Y. Hung Research Professor and Professor of ObGyn, Reproductive Science in Medicine, Northwestern University, Chicago, Illinois, has delivered a conference at the Annual International Medical Conference of the Endometriosis Foundation of America held in New York on April 1-2, 2023. Current valid main scientific theories of endometriosis include Sampson’s retrograde menstruation besides metaplasia of cells that transdifferentiate into endometrial cells at ectopic sites. Problems of modeling endometriosis are inherent to the multifactorial heterogeneous nature of the illness as well as…
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Epigenetic defects of stromal cells in endometriosis and adenomyosis lead to estrogen sensitivity
Serdar Bulun, MD, J.J. Sciarra Professor and Chair Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois has delivered a conference on “Endometriosis and adenomyosis: single-cell genome-wide approaches” at the Annual International Medical Conference of the Endometriosis Foundation of America held in New York on April 1-2, 2023. Professor Bulun reviewed the molecular alterations in two closely related entities, endometriosis, and adenomyosis which could widen our current approaches in these enigmatic disorders that would affect the current pathogenetic and…
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Stem cells could be a good choice for therapeutic steps in many gynecologic disorders, including endometriosis
Dr. Liu from the First Hospital of Jilin University, China, and colleagues from China and the USA have published their comprehensive review on the therapeutic gateways of stem cells in female genital tract disorders in a recent issue of Life Sciences. A great number of women worldwide suffer from infertility associated with gynecologic disorders including endometriosis. There are drawbacks and potential safety hazards associated with therapeutic modalities for these disorders. Currently, the use of stem cells is being questioned as…
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Antioxidant astaxanthin has promising effects on endometriosis-related infertility.
Dr. Rostami and colleagues from the Tehran University of Medical Sciences, Iran, have published a pioneering clinical study on the effects of antioxidant astaxanthin supplementation in infertile endometriosis patients in the scientific journal named Frontiers in Endocrinology. A complicated network of molecular, cellular, and hormonal factors operate in the pathogenic mechanisms for lowered reproduction in endometriosis patients: Endometriosis occurs in an inflammatory microenvironment, in addition to the oxidative stress and high iron content from red blood cells, along with menstrual…
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Serum Galectin-9 : A promising marker for endometriosis diagnosis
Dr. Jarollahi and colleagues from Iran University of Medical Sciences, Tehran have published their research on serum levels of Galectin-9 as a noninvasive marker for endometriosis in the "Journal of Reproduction & Infertility". Endometriosis imposes a great challenge in the current diagnostic algorithm where it is still the gold standard to visualize directly via laparoscopic examination, which is not feasible as a first-line approach due to its costs and risks. Galectins are members of β-galactoside binding lectins, homologous with an…
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Histopathologic examination always has the final word in tubal endometriosis
Hai-Ning Jiao and coworkers from the Department of Obstetrics and Gynecology of Shanghai Jiao Tong University School of Medicine, China, reported the salient features of 30 tubal endometriosis cases in the World Journal of Clinical Cases. Tubal endometriosis is characterized by ectopic endometrial glands and/or stroma within any part of the uterine tubes. It is notoriously hard to diagnose and is generally detected by histopathologic examination of tissues removed, i.e., microscopic assessment, postoperatively. This retrospective study, among the data of…
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Antiinflammatory lactoferrin molecule and antibody levels in endometriosis patients
A Japanese clinical research team led by Dr. Kaya Mori-Yamanaka from Shiga University of Medical Science Hospital, Otsu, Shiga, Japan, published their pioneering study on the role of serum lactoferrin and anti-lactoferrin antibody levels in endometriosis in a recent issue of Tohoku Journal of Experimental Medicine. Lactoferrin is a single-chain glycoprotein found in human mucosal secretions and milk having well-known anti-inflammatory effects. Besides inhibiting inflammatory substance synthesis, oxygen radical formation, and complement activation, lactoferrin also inhibits endogenous neutrophil extracellular trap formation…
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From Finland : How to increase health issues in endometriosis patients
Dr. Henna-Riikka Rossi and associates from the University of Oulu, Oulu, Finland have published their recent prospective cohort study on possible existing comorbidities of endometriosis patients in the journal Fertility and Sterility. Endometriosis is an estrogen-dependent chronic ailment affecting about 6-10% of women which may be associated with painful periods, dyspareunia, chronic pelvic pain, abdominal bloating, nausea, fatigue, and sometimes depression, anxiety, and infertility. Besides, this common gynecological disorder seems to have an increased risk of other health issues like…
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Is the pathogenesis of endometriosis hidden in immune-related gene profiles ?
Yanan He and colleagues from the Department of Gynecology, Harbin Medical University, China have published their manuscript on potential immune markers in endometriosis in a recent issue of “Journal of Immunology Research” Pathophysiologic mechanisms involving endometriosis are complicated and have various parameters like local inflammation, proliferation, invasion, and angiogenesis of endometrial cells. All these have not been well understood yet. The majority agrees that immune factors have a major role in the viability of ectopic endometria with depressed immunosurveillance and…
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