Vitamin D and Endometriosis

Vitamin D and Endometriosis By Engin Aydin

Scientists from Milan, Italy reviewed the effects of vitamin D on the reproductive health, and in particular "endometriosis" in their article which appeared in International Journal of Molecular Sciences. Vitamin D (VD), is a steroid hormone that is activated in…

Key Points Lay Summary

Epigenetic link between endometriosis and cancer

Epigenetic link between endometriosis and cancer By Engin Aydin

Although endometriosis is considered a benign condition the cellular, histologic, and molecular data strongly demonstrate that endometriosis has neoplastic characteristics. There is strong evidence that endometriosis shares striking features with malignancy like normal tissue dissemination, invasion, and organ damage, as well as new vessel formation (neoangiogenesis).  In…

Key Points Lay Summary

Link Between Type of Endometriosis and Cancer

Link Between Type of Endometriosis and Cancer By Özge Özkaya

The type of endometriosis a woman has could determine her risk of gynecologic cancer, according to a study published in the journal Obstetrics & Gynecology. This is important because it means that those women who are at a higher risk…

Key Points Lay Summary

Managing of endometriosis and associated ovarian cancer risk

Managing of endometriosis and associated ovarian cancer risk By Yu Yu

According to a number of studies, endometriosis is associated with moderate increase in ovarian cancer risk. This risk is elevated in subjects with a long-standing history of untreated ovarian endometriosis. Endometriosis is particularly associated with risk for certain histological subtypes…

Key Points Lay Summary

Are there any risk factor associated with the progression of endometriosis to ovarian cancer?

Are there any risk factor associated with the progression of endometriosis to ovarian cancer? By Murat Osman

Endometriosis is a disease whereby endometrial glands proliferate outside of the endometrial lining. Apart from causing significant morbidity, It has been found that endometriosis is associated with an increased risk of progression to endometroid and clear cell ovarian cancer. However,…

Key Points Lay Summary

Is the presence of endometriosis associated with a survival benefit in pure ovarian clear cell carcinoma?

Is the presence of endometriosis associated with a survival benefit in pure ovarian clear cell carcinoma? By Dr. Youngran Park

Ovarian clear cell carcinoma (OCCC) has been known to be associated with endometriosis for a long time. However, the impact of the presence of endometriosis around the tumor on the prognoses of women with OCCC is still controversial. To shed…

Key Points Lay Summary

When Endometriosis Becomes Malignant

When Endometriosis Becomes Malignant By Kasthuri Nair

Anglesio and Yong recently wrote a review titled “Endometriosis-associated Ovarian Cancers” that was published in Clinical Obstetrics and Gynecology. This review explored the relationship between endometriosis and ovarian cancers. It is important to note that this review is a compilation of…

Key Points Lay Summary

Women with Endometriosis Should Not Worry About Ovarian Cancer

Women with Endometriosis Should Not Worry About Ovarian Cancer By Kasthuri Nair

Kvaskoff, Horne and Missmer recently published an article in The Lancet titled “Informing women with endometriosis about ovarian cancer risk.” This article was written to address the growing concern surrounding the information that women suffering from endometriosis are at increased…

Key Points Lay Summary

Intestinal Endometriosis and Colorectal Cancer versus T4 Colorectal Cancer

Intestinal Endometriosis and Colorectal Cancer versus T4 Colorectal Cancer By Kasthuri Nair

Ishii et al. recently published a paper titled “Intestinal endometriosis combined with colorectal cancer: a case series” in the Journal of Medical Case Reports. This case report follows 7 Japanese women who have intestinal endometriosis and colorectal cancer. These women…

Key Points Lay Summary

EFA Medical Conference 2017: "Ovarian Cancer" Presentation by  Dr. Jeannine Villella

EFA Medical Conference 2017: By Kasthuri Nair

Dr. Jeannine Villella, the Chair of Gynecologic Oncology in the Department of OBGYN at Lenox Hill, presented at the 2017 EFA Medical Conference. Her presentation was titled “Ovarian Cancer, ” and she discussed the similarities, differences, and links between ovarian…

Key Points Lay Summary

A Potential New Drug for Endometriosis?

A Potential New Drug for Endometriosis?  By Özge Özkaya

A steroid derivative called PBRM could be a new emerging drug to treat endometriosis according to a study by Canadian scientists. In the study that was published in The Journal of Steroid Biochemistry and Molecular Biology, researchers characterized the pharmaceutical…

Key Points Lay Summary

Hormonal Contraceptives and the Risk of Breast Cancer

Hormonal Contraceptives and the Risk of Breast Cancer By Kasthuri Nair

A study titled “Contemporary Hormonal Contraception and the Risk of Breast Cancer” was recently published in The New England Journal of Medicine and was immediately picked up and summarized by many well-known newspapers and broadcasting journals, including but not limited…

Key Points Lay Summary

Endometriosis pathogenesis through the lens of reactive oxygen species

Endometriosis pathogenesis through the lens of reactive oxygen species By Yu Yu

Oxidative stress caused by reactive oxygen species is an essential factor in endometriosis pathogenesis. The harmful effects of reactive oxygen species have been implicated in many diseases, although the multiple biological changes caused is unclear especially in endometriosis. The article…

Key Points Lay Summary

EFA Medical Conference 2017: “Literature Review, Our Data, and Case Presentations” by Dr. Karli Goldstein

EFA Medical Conference 2017: “Literature Review, Our Data, and Case Presentations” by Dr. Karli Goldstein By Özge Özkaya

Dr. Karli Goldstein started her presentation with a brief literature review on the relationship between endometriosis and breast cancer. She focused on a research article by Dr. Spandidos and colleagues, which was the first epidemiological study that examined the possible…

Key Points Lay Summary

EFA Medical Conference 2017: "Prophylactic Mastectomy and Breast Reconstruction" Presentation by Dr. Oren Lerman

EFA Medical Conference 2017: By Özge Özkaya

Dr. Oren Lerman, a plastic and reconstructive surgeon at Lenox Hill Hospital in New York City, described the reconstructive options of a woman who has been or is going to go through a mastectomy (removal of breast tissues) whether it…

Key Points Lay Summary

EFA Medical Conference 2017: "Cells Are the New Cure" Presentation by Dr. Max Gomez

EFA Medical Conference 2017: By Kasthuri Nair

Dr. Max Gomez is an award-winning broadcast journalist, CBS News Medical Correspondent, and a presenter at the EFA 2017 Medical Conference. Dr. Gomez’s presentation was titled “Cells Are the New Cure: The Cutting-Edge Medical Breakthroughs That Are Transforming Our Health.”…

Key Points Lay Summary

EFA Medical Conference 2017: "The Environmental Risks of Breast Cancer" Presentation by Dr. Marisa Weiss

EFA Medical Conference 2017: By Kasthuri Nair

The second speaker in the subsection of the conference titled “Estrogen from Inflammation to Cancer: A Distant Link?” was Dr. Marisa Weiss and she gave a presentation titled “The Environmental Risks of Breast Cancer: Common Ground with Endometriosis.” Dr. Weiss…

Key Points Lay Summary

EFA Medical Conference 2017: Welcome Presentation by Dr. Tamer Seckin

EFA Medical Conference 2017: Welcome Presentation by Dr. Tamer Seckin By Kasthuri Nair

The first part of the Endometriosis Foundation of America’s 2017 Medical Conference delved into the mission and history of the Endometriosis Foundation of America. The first presenter was Dr. Tamer Seckin, a renowned surgeon, and gynecologist who is also the…

Key Points Lay Summary

Estrogen Receptor-β in Women’s Health

Estrogen Receptor-β in Women’s Health By Yu Yu

Since the discovery of estrogen receptor (ER), there has been a vast number of studies regarding its functions in cellular and physiological processes. The identification of estrogen receptor-β (ERβ), a second receptor, resulted in a much more complex understanding of the…

Key Points Lay Summary

An update of estrogen receptors on human disease

An update of estrogen receptors on human disease By Yu Yu

Estrogens and its receptors influence numerous human physiological processes. Two estrogen receptors exist, including estrogen receptor α (ERα) and ERβ. Hence, it is essential to elucidate the functions of these receptors in healthy and diseased states. This is particularly important…

Key Points Lay Summary

Endometriosis Does Not Increase Overall Risk of Breast Cancer, Study Finds

Endometriosis Does Not Increase Overall Risk of Breast Cancer, Study Finds By Özge Özkaya

Endometriosis is not associated with the overall risk of breast cancer, according to a study published in the journal Obstetrics & Gynecology.  The condition may, however, be significantly associated with an increased risk of breast tumors that express estrogen receptors (ER)…

Key Points Lay Summary

Is there a risk of developing breast cancer for women with endometriosis?

Is there a risk of developing breast cancer for women with endometriosis? By Murat Osman

Understanding the interplay between the development of breast cancer and the presence of endometriosis and vice versa is complex since many risk factors including hormone or genetic variations and medical treatments have a role in each disease process. Thus, parsing…

Key Points Lay Summary

Endometriosis linked with increased risk of cancer and frequency of future surgical procedures

Endometriosis linked with increased risk of cancer and frequency of future surgical procedures By Vishaan Nursey

The purpose of this data research was to determine how women with endometriosis might be predisposed to other medical conditions later on in their lives. In order to determine if endometriosis affected health outcomes, a group of Scottish researchers collected…

Key Points Lay Summary

Is there any association between menstrual pain and ovarian cancer?

Is there any association between menstrual pain and ovarian cancer? By Yu Yu

Inflammation may be important in ovarian carcinogenesis. Epidemiological studies show that inflammatory conditions such as endometriosis and pelvic inflammatory disease have been associated with an increased risk of ovarian cancer, while regular use of non-steroidal anti-inflammatory drugs has reduced associated…

Key Points Lay Summary

New Approach could help Preoperative Differentiation of Endometriosis and Cancer

New Approach could help Preoperative Differentiation of Endometriosis and Cancer By Özge Özkaya

Researchers in Japan identified some radiological parameters that could be used to differentiate between endometriosis-associated ovarian cancer (EAOC) and a particular type of benign ovarian endometriosis (OE), making it easier for doctors to offer the right treatment to women who…

Key Points Lay Summary

Does endometriosis increase skin cancer risk?

Does endometriosis increase skin cancer risk? By Demet Candaş Green

Two major types of skin cancer are melanoma, which is the least frequent type but with highest metastatic potential; and non-melanoma skin cancers which include basal cell carcinoma and squamous cell carcinoma. Several risk factors are identified for skin cancer…

Key Points Lay Summary

Endometriosis and Ovarian Cancer Risk

Endometriosis and Ovarian Cancer Risk By Yu Yu

Ovarian cancer prevalence in women with endometriosis is higher than the general population. It is often hypothesized that endometriosis-associated malignancies can occur from ovarian endometrioma. This systematic review by Taniguchi highlighted new insights on the relationship between endometriosis and ovarian…

Key Points Lay Summary

Endometriosis : A Whole Body Disease

Endometriosis : A Whole Body Disease By Kasthuri Nair

Endometriosis is a disease that impacts multiple parts of an individual’s body. Seminars in Reproductive Medicine recently published a paper by Alderman III et al. entitled “The Systemic Effects of Endometriosis” explores the various comorbidities that can affect individuals suffering…

Key Points Lay Summary

Is it Estrogen that Regulates Endometriosis Pain?

Is it Estrogen that Regulates Endometriosis Pain? By Yu Yu

Endometriosis-associated pain is a debilitating condition; however, it is surprising that the perceived pain has no correlation to the endometriosis extent. The mechanism that causes the pain is also poorly understood. Nerve growth factor is enhanced in endometriosis and may increase…

Key Points Lay Summary

Mutations Associated with Cancer Were Identified in "Endometriosis without Cancer"

Mutations Associated with Cancer Were Identified in By Özge Özkaya

Lesions in deep infiltrating endometriosis harbor genetic mutations that are associated with cancer, found a study published in the New England Journal of Medicine.  The authors believe that this new discovery may help to distinguish between aggressive and non-aggressive forms of…

Lay Summary

Unexpected "cancer-related" mutations in "non-cancerous" endometriosis: Do they predict aggressiveness?

Unexpected By Laura Ardighieri

A study supported by Endometriosis Foundation of America, reported by scientists from Johns Hopkins Medicine (Baltimore, USA) and the University of British Columbia (Vancouver, Canada) have identified the molecular alterations of deep infiltrating endometriosis trough a wide exome­ sequencing (protein-coding genetic alphabet…

Key Points Lay Summary

Genetic Variations May Link Risk of Endometriosis and Ovarian Cancer

Genetic Variations May Link Risk of Endometriosis and Ovarian Cancer By Özge Özkaya

Variations in a gene called HNF1B could be linked to the risk of endometriosis, according to a study published in the medical journal Gynecologic Oncology. Previous studies had identified the same genetic variation as a risk factor for ovarian cancer.…

Lay Summary

Increased Oxidative Stress in Endometriosis may Be Linked to Higher Risk of Ovarian Cancer

Increased Oxidative Stress in Endometriosis may Be Linked to Higher Risk of Ovarian Cancer By Ezio Rosato

In the study that was published in the scientific journal Translational Oncogenomics, a group of researchers led by Dr. Hariyono Winarto from the Universitas Indonesia in Jakarta identified increased oxidative stress as one of the causes that might explain the…

Lay Summary

Laparoscopic Hysterectomy as Effective as Total Abdominal Hysterectomy, Study Suggests

Laparoscopic Hysterectomy as Effective as Total Abdominal Hysterectomy, Study Suggests By Ezio Rosato

Laparoscopic hysterectomy, a minimally invasive surgical procedure that is used to remove the uterus, results in similar rates of disease-free survival among women with stage 1 endometrial cancer as the standard abdominal hysterectomy, showed a study published in The Journal…

Lay Summary