Dr. Youngran Park

Dr. Park received her Ph.D. in Pathobiology from Johns Hopkins University School of Medicine and is currently a postdoctoral research fellow at JHU. She received Pathology Young Investigator Day Award at 2016 and 2017 for her study of ARID1A function in DNA repair. She strongly believes the spirit of translational research is to alleviate human suffering through research.

The role of acidic ribosomal protein P1 in Endometriosis

Endometriosis is an estrogen-dependent disorder. The disease develops and composed of the ectopic endometrial-like tissue which establishes primarily in the pelvic cavity. Previous findings clearly show that estrogen-related factors are critical for endometriosis development and progression. However, we do have a limited understanding of the complexity of the environment. RPLP1 is part of the ribosomal subunit which functions in regulating protein elongation translation factors. Interestingly, its expression is regulated by the estrogen target gene, c-Myc. According to previous research, RPLP1…

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Impact of Genetic Variations in Endometriosis

Endometriosis is an estrogen-dependent disorder. This disease affects approximately 7% to 10% of reproductive-aged women and causes negative impacts on society. The underlying causes are unclear; therefore, the understanding of this disease remains a major clinical challenge. Endometriosis has a complicated etiology, influenced by genetic and environmental factors. Thanks to the current advances in genetics, more than 40 genetic risk factors have been discovered in endometriosis. Also, a significant amount of somatic mutation has been found, expanding the possible functions…

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CXCR4 or CXCR7 antagonists as novel therapies for endometriosis

Endometriosis is a common, estrogen-dependent chronic inflammatory disorder. It affects approximately 5-10% of reproductive-aged women and 20-50% of infertile women. Endometriosis also has a significant social and psychological impact on the lives of women. Despite such a significant burden, there is no endometriosis-specific treatment available. Bone marrow-derived stem cells (BMDCs) are shown to be involved in the pathogenesis of endometriosis by contributing regeneration and vascularization at the endometriotic lesions. In cancer and/or inflammation conditions, BMDCs get stimulated by chemokines and…

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When to do - and when not to do surgery for endometriosis

Endometriosis is an estrogen-dependent disorder. It was estimated to affect about 176 million women in the world and usually causes pelvic pain and infertility. Unfortunately, the current understanding of this disease is very limited. Though there are many remaining questions, the key question is how to treat patients with the disease.  Several managements are available such as hormonal contraceptives, progestins, and gonadotropin-releasing hormone agonists (GnRH-a) or antagonists. Still, the most frequently used management is laparoscopic surgery. Current therapeutic decision-making is…

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The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis

Endometriosis is a very common gynecological disorder affecting approximately 10% of reproductive-aged women, and it is known by the abnormal growth of endometrial stroma and glands outside the uterus. Though the pathogenesis of endometriosis is not clearly understood so far, several findings suggest that inflammation plays a critical role in endometriosis initiation and progression. Also, other critical factors such as oxidative stress, apoptosis signaling, and angiogenesis are suggested. In this review, the Dr. Asemi group from Iran summarized the current…

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Endometriosis features vs Patient age

Endometriosis, a common gynecological disease, has significant negative impacts on patients’ daily life. Especially in younger women who have yet to achieve pregnancy, effective management should consider the disease progression. Though it is still under debate, some people suggest that the severity of lesions increases with patient age. This suggests that endometriosis lesions might grow over time. To assess the relationship between age and the type, stage and location of endometriotic lesions, the Dr. Roman group from France performed a…

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A new target for the treatment of endometriosis?

Endometriosis affects around 10% of women in reproductive age, estimating more than 176 million women worldwide. Inflammation in the pelvic cavity is very common in endometriosis patients. Therefore, there are high concentrations of cytokines and immune cells in the peritoneal fluids.  The concentrations of the pro-inflammatory prostaglandins (PG)E2 and PGF2a are increased in peritoneal fluid of endometriosis, compared to the healthy women. The main reason for this increase is due to the overexpression of genes that encode prostaglandin synthases in…

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Machine Learning Classifiers for Endometriosis

Endometriosis is a complicated gynecological disorder that affects about 176 million women worldwide. It significantly impairs mental and physical quality of life in patients but the etiology is poorly understood. Endometriosis also causes a large economic burden due to loss of workdays and the health-care costs due to hospitalization and medication. Unfortunately, a definitive clinical symptom or minimally invasive diagnostic method is not available and this causes on average 4 to 11 years diagnostic latency. Therefore, early intervention is crucial…

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Endometriosis as an epigenetically regulated disease

Endometriosis is defined as the abnormal growth of endometrial tissue outside of the uterus. It affects about 10% of reproductive age women resulting in severe pain and infertility. Among various theories of endometriosis pathogenesis, not a single one has successfully elucidated the mechanism of endometriosis. In recent years, many studies focus on the epigenetic signature of endometrial cells to understand endometriosis pathogenesis. Epigenetic change does not involve alteration of the DNA sequence but has significant effects on gene expression. DNA…

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Does ovarian endometriosis affect oocyte quality?

Endometriosis is a very common gynecological disorder affecting women in their reproductive years. It is reported that patients with endometriosis have reduced implantation and pregnancy rates compared to healthy women. According to the various previous studies, the quality of the oocytes seems to be highly affected by the ovarian endometriosis. Previous studies showed that the implantation rate was significantly reduced when people received embryos derived from endometriotic ovaries compared to the people received embryos from healthy donors. Interestingly, it is…

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MicroRNA Inhibitor as an Endometriosis treatment

Endometriosis is a well-known estrogen-dependent gynecological disorder. This disease affects approximately 20% to 50% of infertile women and 10% of reproductive-aged women resulting in infertility and pelvic pains.  In order to find endometriosis-specific treatment, various studies have been tried to identify molecular signatures which are ectopically expressed in endometriosis patients. Unfortunately, current medical treatment is not endometriosis specific but targets sex steroids broadly. Therefore, precision medicine, which reduces side effects significantly, is highly required for medically treating endometriosis in the…

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Impact of Endometriosis on Embryo Development

Endometriosis is a hormone-dependent disorder which affects approximately 10% of women in reproductive age. There are many endometriosis-related problems, but infertility is one of the well-known issues which should be handled and understood. Despite numerous trials, the mechanisms and pathology of how endometriosis specifically leads to infertility are largely unknown. Therefore, more investigations are required for a better understanding. Several studies have been suggested that endometriosis is associated with unfavorable conditions for fertility such as impaired fertilization, elevated oxidative stress,…

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DNA repair defects and Endometriosis

Endometriosis is a hormone-dependent disorder and highly associated with inflammation. It is well suggested that endometriosis increases the risks of developing cancers such as ovarian, breast, endocrine, and colorectal cancers. Compared to cancer, there are many similarities in endometriosis. Well-known characteristics in cancer such as genomic instability, the increased mutation rate in oncogenes, microsatellite instability, tissue-specific gene copy number changes, and lower expression of DNA repair enzymes are highly implicated in endometriosis. DNA repair deficiency got lots of attention in endometriosis.…

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Plausible biomarkers for noninvasive endometriosis diagnosis

Endometriosis is an estrogen-dependent benign gynecological disease characterizing ectopic deposition of endometrial tissue outside of the uterine cavity. It affects about 10% of reproductive-aged women and causes enormous negative impacts on the quality of lives. However, we do not have a non-invasive diagnostic procedure until now. Furthermore, there is no single published biomarker which was clinically validated. According to the previous study, the ideal biomarker is the one which is specific to the disorder, can be detected early in the…

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The Effect of Imbalanced Progesterone Receptors-A/B on Gelatinase Expressions in Endometriosis

Endometriosis is a benign disease which affects approximately 10% of reproductive-aged women and is one of the most common reasons for infertility. Though the underlying mechanisms of disease progression have not been clearly understood, it develops as a consequence of ectopic implantation of retrograded menstrual tissue. Endometriosis significantly decreases the quality of life. The frequency of endometriosis in females with complaints of pain, infertility, or both symptoms is between 35 and 60%. Among the many problems caused by endometriosis, the…

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Seven Hormonal Biomarkers for Diagnosing Endometriosis

Endometriosis is an inflammatory condition characterized by implantation and invasive growth of endometrial tissue outside the uterine cavity. Although it is benign, endometriosis has cancer-like features, a mutation profile similar to that of ovarian cancer, and increased ovarian cancer risk. Therefore, it is of great significance to correctly diagnose endometriosis. Laparoscopy with histology of excised endometriosis lesions remains the gold standard for diagnosis, but it also has numerous disadvantages such as high cost, need for general anesthesia, and risk of…

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Novel inhibitors of estrogen biosynthesis

Endometriosis is a chronic benign disease which is estrogen-dependent. Estradiol creates a positive feedback loop with the synthesis of pro-inflammatory mediators, which sustains further disease establishment and causes the pain symptoms. However, hormone therapies do not cure definitively endometriosis, because of recurrence and lack of evidence that hormonal drugs improve spontaneous fertility of patients with endometriosis. Recently, several studies provided strong evidence that aberrant in-situ estrogen biosynthesis occurs in endometriosis. Therefore, the development of new molecules acting on such local…

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The Wnt/b-catenin signaling in endometriosis

Endometriosis is a very common gynecological disorder, which affects approximately 10% of reproductive-aged women, and is one of the most common reasons for infertility. The normal endometrium undergoes cyclical remodeling under control of sex hormones secreted by ovaries- estrogen and progesterone. It has been accepted that estrogen and progesterone were regulated by Wnt/b-catenin signaling. In a recent study, inhibition of Wnt/b-catenin signaling repressed the main characteristics of endometrial cells involved in the development of endometriosis including cell migration, proliferation, and…

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Fibrogenesis in endometriosis: The role of neuropeptides

Endometriosis is a debilitating gynaecologic disease affecting 6–10% of women of reproductive age. Endometriotic lesions are known to be hyperinnervated due to neurogenesis resulting from neutrophins secreted by endometriotic lesions and possibly platelets. These neutrophins seem to preferentially favor the production of sensory neurons at the expense of sympathetic neurons. The striking histological relationship between nerves and the extent of fibrosis in the endometriosis lesions raise the possibility that nerves, especially sensory nerves, may facilitate the development and fibrogenesis of…

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Anti-angiogenic treatment for endometriosis

Endometriosis is a benign, estrogen-dependent gynecological disorder. The wide variety of surgical and medical treatment has been applied for treating endometriosis, but a definitive therapy has not been achieved so far. Thus, new therapeutic strategies need to be developed. Among them, gene therapy recently has shown that it can be practically attainable for endometriosis. Especially, developing a delivery system using cell-specific receptors is getting more attention to increase the specificity of gene therapy. Dr. Kiselev group, Ott Research Institute from…

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