Dr. Youngran Park

Dr. Park received her Ph.D. in Pathobiology from Johns Hopkins University School of Medicine and is currently a postdoctoral research fellow at JHU. She received Pathology Young Investigator Day Award at 2016 and 2017 for her study of ARID1A function in DNA repair. She strongly believes the spirit of translational research is to alleviate human suffering through research.

Therapeutic Roles of Statins in Gynecology and Obstetrics.

Statins are a class of drugs, which act by inhibiting the rate-limiting enzyme of cholesterol biosynthesis, which reduces lipid production. Therefore, statin has been used for the treatment of hypercholesterolemia and coronary artery disease. This study published in Reproductive Sciences performed by Zeybek et al., and the researchers from the Department of Obstetrics & Gynecology, The University of Texas and the Johns Hopkins University School of Medicine, USA, summarize the literature search for articles related to statins in obstetrics and gynecology.…

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Is the presence of endometriosis associated with a survival benefit in pure ovarian clear cell carcinoma?

Ovarian clear cell carcinoma (OCCC) has been known to be associated with endometriosis for a long time. However, the impact of the presence of endometriosis around the tumor on the prognoses of women with OCCC is still controversial. To shed more light on this issue, this group designed a retrospective and dual-institutional study with a well-defined, and homogeneous study population. A total of 93 women met the inclusion criteria. Of these patients, 48 were diagnosed with OCCC arising in endometriosis,…

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Epigenetic regulation of the pathological process in endometriosis.

Epigenetic mechanisms have been recognized as important players in the development of a broad range of human diseases including endometriosis. A growing body of evidence shows that the remodeling of retrograde endometrial tissues to the ectopic endometriotic lesions involves multiple epigenetic alterations such as DNA methylation, histone modification, and microRNA expression. Therefore, in this review, the author focuses on how epigenetic regulatory factors contribute to the development and maintenance of endometriosis. First, the alteration of DNA methylation has been known to…

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The Use of Resveratrol as an Adjuvant Treatment of Pain in Endometriosis

Endometriosis is considered a predominantly estrogen-dependent disease, and therefore hormonal suppression might be an attractive medical approach to treat this disease and its symptoms. Resveratrol is a natural phytoestrogen synthesized by plants and has known to have side effects such as mild, mainly related to a headache and drowsiness. The use of resveratrol has been suggested to treat endometriosis, due to its anti-proliferative action, but the potential benefits and harms have not been demonstrated in endometriosis patients. Therefore, this group…

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The Deregulated Molecular Functions Involved in Malignant Transformation of Endometriosis to Endometriosis-Associated Ovarian Carcinoma

Endometriosis-associated ovarian cancer (EAOC) is postulated to be transformed from endometriosis. Though different deregulated functional areas were proposed accounting for the pathogenesis of EAOC transformation, there is a lack of data-driven analysis to prove this. To understand the EAOC pathogenesis better, this group conducted the function-based, data-driven study to investigate complex diseases with the functionomes. They used microarray gene expression datasets of endometriosis, CCC, and EC from the National Center for Biotechnology Information Gene Expression Omnibus (NCBI GEO) database. The group…

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How good are the current guidelines on endometriosis? 

The endometriosis was first described in 1860, yet the etiology and pathogenesis remain poorly understood. Treatment strategies vary significantly between disease severity and the symptoms of pain and/or subfertility. These challenges have resulted in multidirectional research, and the comparability of research to inform patient care through evidence synthesis in the context of guideline formation and patient information. Therefore, an appropriate and rigorous guideline development is highly required to improve patient care. This is the first study to systematically appraise the…

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Autophagy in endometriosis

Endometriosis is a common gynecologic disease affecting both fertile (5-10%) and infertile (20-50%) women, and it commonly causes chronic pelvic pain, dysmenorrhea, and infertility. Recent research found that the autophagy exerts a pro-apoptotic effect on normal human endometrial cells and it is significantly reduced in endometriosis-derived endometrial tissues compared with the normal endometrium. Based on accumulating in vivo and in vitro evidence, the level of autophagy is most likely associated with the pathogenesis of endometriosis. Therefore, this paper systematically reviews…

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Investigational Medical Therapies for Endometriosis: Current Data and Future Trends. 

The medical treatment of endometriosis has traditionally relied on hormonal therapies. Because these hormonal therapies preclude fertility or may have unwanted side effects, there is a great need for novel hormonal and non-hormonal medical options. Therefore, this review focuses on investigational medical therapies based on in vitro and in-vivo models of endometriosis and assesses the safety and efficacy. It has been suggested that endometriosis, currently treated with GnRH agonists, may be more effectively treated with GnRH antagonists. Several animal studies have demonstrated the…

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Autophagy in endometriosis: Friend or foe?  

Endometriosis is a chronic, estrogen-dependent disease and affects an estimated 10% of the female population of reproductive age. Unfortunately, the etiology of endometriosis is not clear. Recently emerging evidence shows that there is a close relationship between endometriosis and autophagy. However, the precise mechanism has not been fully elucidated yet. This paper provides acquired findings of the connections between endometriosis and autophagy. Also, they discuss which may contribute to the abnormal level of autophagy in endometriosis. Several papers have suggested…

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Endometriosis and Oxidative Stress

The etiology of endometriosis is still unclear. However, it is now widely accepted that oxidative stress, defined as an imbalance between reactive oxygen species (ROS) and antioxidants, may be implicated in the pathophysiology of endometriosis causing a general inflammatory response in the peritoneal cavity.  Scuterio G et al. from the University of Ferrara, Italy, made a systematic review of the literature recently published in the journal "Oxidative Medicine and Cellular Longevity". This study explores the functions of oxidative stress and its role…

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Revisiting the wandering womb: Oxytocin in endometriosis and bipolar disorder

Despite a Hysteria (from Greek hysterikos, meaning ‘of the womb’) was dismissed as causing mental illness, recent evidence links oxytocin with diverse and correlated psychological and physical symptoms and conditions that more frequently affect women than men. This article proposes the novel hypothesis that elevated oxytocin activity jointly mediates risk of bipolar disorder and endometriosis in women. The elevated oxytocinergic activity appears to increase uterine movement, interpersonal distress, and relationship anxiety especially in women, which are the significant characteristics of…

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