Endometriosis May Be Causing Women to Become More Sensitive to Pain

Endometriosis May Be Causing Women to Become More Sensitive to Pain By Özge Özkaya

Inflammation caused by endometriosis may be changing the way a woman perceives pain, found a new study published in the journal Regional Anesthesia and Pain Medicine.   According to Dr. Neziri Alban at University Hospital of Bern, Switzerland and the co-authors…

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The Role of Natural Killer Cells in the Development of Endometriosis Unravelled

The Role of Natural Killer Cells in the Development of Endometriosis Unravelled By Özge Özkaya

Specialized immune cells called natural killer cells found in the peritoneal fluid of women with severe endometriosis may facilitate the development of the disease, according to a study published in the American Journal of Reproductive Immunology.   This finding could help…

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A Two-Wave Molecular Mechanism for Endometriosis Disease Progression

A Two-Wave Molecular Mechanism for Endometriosis Disease Progression By Kasthuri Nair

Kobayashi et al. recently published a review paper in Molecular Medicine Reports titled “Pathogenesis of endometriosis: The role of initial infection and subsequent sterile inflammation,” which discusses at length the role of non-specific bacterial infection and sterile inflammation in the…

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Mitogen-Activated Protein Kinase p38 modulates Inflammation in Endometriosis

Mitogen-Activated Protein Kinase p38 modulates Inflammation in Endometriosis By Yu Yu

The p38 mitogen-activated protein kinase (MAPK) is a serine/threonine kinase, which transduces signals within the cell in response to various environmental stimuli. In doing so, it mediates intracellular signaling of cytokine production, cell proliferation, and apoptosis amongst many other cellular…

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CCL19/CCR7 Interaction can Casue Characteristic Cell Proliferation

CCL19/CCR7 Interaction can Casue Characteristic Cell Proliferation By Kasthuri Nair

In their paper published in the American Journal of Reproductive Immunology titled “CCL19/CCR7 contributes to the pathogenesis of endometriosis via PI3K/Akt pathway by regulating the proliferation and invasion of ESCs,” Diao et al. hope to elucidate one of the mechanisms…

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Interleukin-6 Involved in the Development of Endometriosis

Interleukin-6 Involved in the Development of Endometriosis By Özge Özkaya

A chemical produced by the body called Interleukin-6 (IL-6) and known to be involved in inflammation also seems to promote the development of endometriosis. This is according to a study by Chinese scientists published in the journal Medical Science Monitor.…

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Plant Compound May Protect Against Endometriosis

Plant Compound May Protect Against Endometriosis By Özge Özkaya

Marrubiin, a compound derived from a plant in the mint family called white horehound may have protective effects against endometriosis, according to a study published in the journal Molecular Medicine Reports.  Marrubiin is the main analgesic, or painkiller compound found…

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The Role of IL-35 in the Pathogenesis of Endometriosis

The Role of IL-35 in the Pathogenesis of Endometriosis By Kasthuri Nair

The molecular mechanism that drives endometriosis remains elusive to this day. Zhang et al believe that interleukin 35 (IL-35) plays a role in the pathogenesis of the disease. Their recent publication in Reproductive Sciences titled “Upregulation of Interleukin 35 in…

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Endometriosis : A Whole Body Disease

Endometriosis : A Whole Body Disease By Kasthuri Nair

Endometriosis is a disease that impacts multiple parts of an individual’s body. Seminars in Reproductive Medicine recently published a paper by Alderman III et al. entitled “The Systemic Effects of Endometriosis” explores the various comorbidities that can affect individuals suffering…

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Immune Response in Endometriosis and Regulatory T cells

Immune Response in Endometriosis and Regulatory T cells By Yu Yu

The adaptive immune system is crucial for many diseases. Lymphocytes, including T cells, are particularly important in the adaptive immune system. Previous research suggested that defective immune response could play a role in endometriosis. The hypothesis proposes that the immune…

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T-Cell Dysfunction May Worsen Endometriosis

T-Cell Dysfunction May Worsen Endometriosis By Murat Osman

Researchers from the Kyoto Prefectural University of Medicine, Japan, have found that T regulatory lymphocytes (Treg) may be the reason for the formation of the chronic inflammatory environment involved in endometriosis, a study published in The Journal of Clinical Endocrinology &…

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TFF3 May Be Involved in Endometriosis Research Suggests

TFF3 May Be Involved in Endometriosis Research Suggests By Özge Özkaya

Levels of a protein called TFF3 are significantly increased in the peritoneal cavity (the abdominal space) of women with endometriosis, found a study published in the scientific journal Reproductive Sciences. This increase was in line with levels of other known…

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Immune substances in peritoneal fluid for endometriosis diagnosis and armamentarium

Immune substances in peritoneal fluid for endometriosis diagnosis and armamentarium By Yu Yu

Cytokines are immune substances secreted by a broad range of cells within the body, including immune cells like the macrophages, B lymphocytes, T lymphocytes, mast cells, and non-immune cells such as the endothelial cells and fibroblasts. They are important in…

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