​Insights into immune dysfunction in endometriosis - Chandrakant Tayade, DVM, PhD

​Insights into immune dysfunction in endometriosis - Chandrakant Tayade, DVM, PhD By Bahar Yuksel

In his speech presented at the Annual International Medical Conference of the Endometriosis Foundation of America held in New York on April 1-2, 2023, Dr. Tayade talks about the relationship between endometriosis and the immune system. Dr. Tayade begins by emphasizing the significance of…

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T-cell-targeted immunotherapy and immune checkpoint inhibitors for the treatment of endometriosis

T-cell-targeted immunotherapy and immune checkpoint inhibitors for the treatment of endometriosis By Nasuhi Engin Aydin

Dr. Monika Abraimuk and colleagues from Poland published their review on "the importance of immunity in endometriosis" in a recent issue of the medical journal “Cellular Signaling”. A great challenge in contemporary medical issues is endometriosis which still lacks a…

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The association between inflammatory cytokines and fertility in women with endometriosis

The association between inflammatory cytokines and fertility in women with endometriosis By Hale Goksever Celik

Women with endometriosis suffer not only from a broad spectrum of symptoms including pain including dysmenorrhea, dyspareunia, and chronic pelvic pain but also fertility problems. Endometriosis-associated infertility develops depending on a combination of several mechanisms such as distorted pelvic anatomy,…

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The Role of Endometrial Cytokines on the Infertility in Endometriosis Patients

The Role of Endometrial Cytokines on the Infertility in Endometriosis Patients By Eylül GÜN

The intrauterine microenvironment and underlying immunological mechanisms in endometriosis pathogenesis have been a popular research topic, mainly due to the efforts to comprehend the reason to elucidate infertility that these patients suffer from. Because of their superiority to other immune…

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Association of psoriasis and endometriosis

Association of psoriasis and endometriosis By Selma Oransay

Psoriasis is an immune-mediated inflammatory skin disease characterized by scalpy, red, and well-demarcated skin plaques that are observed in 2-4% of the population. Approximately 30% of psoriatic patients additionally have joint pain, stiffness, and swelling called psoriatic arthritis. The mechanism…

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Promising potential research topic: diagnostic biomarkers for endometriosis

Promising potential research topic: diagnostic biomarkers for endometriosis By Nasuhi Engin Aydin

Dr. Toczek and collegues from the Department of Gynecology, Obstetrics and Oncological Gynecology of Medical University of Silesia in Katowice, Poland, have  published a review paper on possible diagnostic aid of cytokines in endometriosis. This review appears in May issue…

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Endometrial fluid analysis as a new diagnostic test for endometriosis diagnosis

Endometrial fluid analysis as a new diagnostic test for endometriosis diagnosis By Bahar Yuksel

There is still a huge demand for finding a minimally invasive diagnostic test for endometriosis and yet none has been defined properly. The present study which was conducted in Cleveland Clinic by Natalia C. Llarena et al between March 2017…

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Local inflammation and follicle development in women with ovarian endometriosis

Local inflammation and follicle development in women with ovarian endometriosis By Dr. Youngran Park

Endometriosis, a cause of subfertility, is found in almost 50% of infertile women. The elevated levels of cytokines in the follicular fluid of patients with endometriosis might account for the ovulatory dysfunction. Granulosa cells (GCs) play important roles in follicular…

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Immune System, Cytokines and Endometriosis

Immune System, Cytokines and Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent chronic disease. Diagnosing endometriosis is difficult because the signs and symptoms vary considerably. Therefore, the discovery of a reliable non-invasive diagnostic biomarker would represent a major advance for the clinical diagnosis of endometriosis.  It has been…

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New Insights on Infertility and Low Success Rates of Assisted Reproduction in Women with Endometriosis

New Insights on Infertility and Low Success Rates of Assisted Reproduction in Women with Endometriosis By Özge Özkaya

The fluid surrounding immature eggs waiting to mature and be fertilized by a sperm to lead to pregnancy is different in women with endometriosis compared to those without, according to a study published in Molecular Biology Reports. This could explain,…

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Interleukin-37b inhibits the growth of murine endometriosis-like lesions

Interleukin-37b inhibits the growth of murine endometriosis-like lesions By Nadire Duru

Endometriosis is a chronic gynecological disease that causes chronic pain and infertility in women. Despite continuous efforts and numerous research, there is, ultimately, still much to understand about the pathogenesis of endometriosis. Inflammatory factors including several interleukins have already been…

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Oxidative stress leads to elevated cytokines, excessive structural damage and angiogenesis

Oxidative stress leads to elevated cytokines, excessive structural damage and angiogenesis By Yu Yu

Endometriosis is characterized by elevated intracellular reactive oxygen species, which is then believed to upregulate inflammatory cytokines. Reactive oxygen species also regulate the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which is closely linked with immune responses.…

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Analogous pathways of peritoneal tumor wound healing and endometriosis.

Analogous pathways of  peritoneal tumor wound healing and endometriosis. By Selma Oransay

Endometriosis, diagnosed around 10-15% of women population in their reproductive period, is a chronically progressive inflammatory disease to cause peritoneal lesions while spreading into the abdominal cavity. The pathophysiology of the adhesions between the peritoneum and pelvic organs can be…

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Searching new biomarkers for endometriosis

Searching new biomarkers for endometriosis By Selma Oransay

This recent article published in Advances in Clinical Chemistry, is an overall summary of characteristics, physiopathological theories, diagnostic approaches and variety of biomarkers to diagnose endometriosis and penned by Coutinho et al. from Universidade Federal de Juiz de Fora, Belo Horizonte,…

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Anti-inflammatory cytokines: a new horizon in endometriosis with possible clinical relevance

Anti-inflammatory cytokines: a new horizon in endometriosis with possible clinical relevance By Nasuhi Engin Aydin

Scientists led by Dr. Li from Shangai PRC, have made a comprehensive review of anti-inflammatory cytokines related to the pathogenesis of endometriosis in a recent issue of Cellular and Molecular Life Sciences.    Inflammation is important in the pathogenesis of endometriosis,…

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Endometriosis May Be Causing Women to Become More Sensitive to Pain

Endometriosis May Be Causing Women to Become More Sensitive to Pain By Özge Özkaya

Inflammation caused by endometriosis may be changing the way a woman perceives pain, found a new study published in the journal Regional Anesthesia and Pain Medicine.   According to Dr. Neziri Alban at University Hospital of Bern, Switzerland and the co-authors…

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The Role of Natural Killer Cells in the Development of Endometriosis Unravelled

The Role of Natural Killer Cells in the Development of Endometriosis Unravelled By Özge Özkaya

Specialized immune cells called natural killer cells found in the peritoneal fluid of women with severe endometriosis may facilitate the development of the disease, according to a study published in the American Journal of Reproductive Immunology.   This finding could help…

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A Two-Wave Molecular Mechanism for Endometriosis Disease Progression

A Two-Wave Molecular Mechanism for Endometriosis Disease Progression By Kasthuri Nair

Kobayashi et al. recently published a review paper in Molecular Medicine Reports titled “Pathogenesis of endometriosis: The role of initial infection and subsequent sterile inflammation,” which discusses at length the role of non-specific bacterial infection and sterile inflammation in the…

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Mitogen-Activated Protein Kinase p38 modulates Inflammation in Endometriosis

Mitogen-Activated Protein Kinase p38 modulates Inflammation in Endometriosis By Yu Yu

The p38 mitogen-activated protein kinase (MAPK) is a serine/threonine kinase, which transduces signals within the cell in response to various environmental stimuli. In doing so, it mediates intracellular signaling of cytokine production, cell proliferation, and apoptosis amongst many other cellular…

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CCL19/CCR7 Interaction can Casue Characteristic Cell Proliferation

CCL19/CCR7 Interaction can Casue Characteristic Cell Proliferation By Kasthuri Nair

In their paper published in the American Journal of Reproductive Immunology titled “CCL19/CCR7 contributes to the pathogenesis of endometriosis via PI3K/Akt pathway by regulating the proliferation and invasion of ESCs,” Diao et al. hope to elucidate one of the mechanisms…

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Interleukin-6 Involved in the Development of Endometriosis

Interleukin-6 Involved in the Development of Endometriosis By Özge Özkaya

A chemical produced by the body called Interleukin-6 (IL-6) and known to be involved in inflammation also seems to promote the development of endometriosis. This is according to a study by Chinese scientists published in the journal Medical Science Monitor.…

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Plant Compound May Protect Against Endometriosis

Plant Compound May Protect Against Endometriosis By Özge Özkaya

Marrubiin, a compound derived from a plant in the mint family called white horehound may have protective effects against endometriosis, according to a study published in the journal Molecular Medicine Reports.  Marrubiin is the main analgesic, or painkiller compound found…

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The Role of IL-35 in the Pathogenesis of Endometriosis

The Role of IL-35 in the Pathogenesis of Endometriosis By Kasthuri Nair

The molecular mechanism that drives endometriosis remains elusive to this day. Zhang et al believe that interleukin 35 (IL-35) plays a role in the pathogenesis of the disease. Their recent publication in Reproductive Sciences titled “Upregulation of Interleukin 35 in…

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Endometriosis : A Whole Body Disease

Endometriosis : A Whole Body Disease By Kasthuri Nair

Endometriosis is a disease that impacts multiple parts of an individual’s body. Seminars in Reproductive Medicine recently published a paper by Alderman III et al. entitled “The Systemic Effects of Endometriosis” explores the various comorbidities that can affect individuals suffering…

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Immune Response in Endometriosis and Regulatory T cells

Immune Response in Endometriosis and Regulatory T cells By Yu Yu

The adaptive immune system is crucial for many diseases. Lymphocytes, including T cells, are particularly important in the adaptive immune system. Previous research suggested that defective immune response could play a role in endometriosis. The hypothesis proposes that the immune…

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T-Cell Dysfunction May Worsen Endometriosis

T-Cell Dysfunction May Worsen Endometriosis By Murat Osman

Researchers from the Kyoto Prefectural University of Medicine, Japan, have found that T regulatory lymphocytes (Treg) may be the reason for the formation of the chronic inflammatory environment involved in endometriosis, a study published in The Journal of Clinical Endocrinology &…

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TFF3 May Be Involved in Endometriosis Research Suggests

TFF3 May Be Involved in Endometriosis Research Suggests By Özge Özkaya

Levels of a protein called TFF3 are significantly increased in the peritoneal cavity (the abdominal space) of women with endometriosis, found a study published in the scientific journal Reproductive Sciences. This increase was in line with levels of other known…

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Immune substances in peritoneal fluid for endometriosis diagnosis and armamentarium

Immune substances in peritoneal fluid for endometriosis diagnosis and armamentarium By Yu Yu

Cytokines are immune substances secreted by a broad range of cells within the body, including immune cells like the macrophages, B lymphocytes, T lymphocytes, mast cells, and non-immune cells such as the endothelial cells and fibroblasts. They are important in…

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