Bahar Yuksel, MD

Bahar Yuksel graduated from Istanbul University Istanbul Medical School at the top of the class of 2010. She completed her residency in Istanbul Medical School Obstetrics and Gynecology Department by the top score Residency Board Exam. Between 2016 and 2017 she studied at Stanford School of Medicine and did research about ovarian physiology.  Her projects were funded by The Scientific And Technological Research Council Of Turkey several times. Her main interests are endometriosis and ovarian physiology. Now she has her practice in Istanbul as an Ob&Gyn , member of Turkish Endometriosis and Adenomyosis Society and works for the Endometriosis Foundation of America (EndoFound.org) as Research Associate.

Genetic prediction models for endometriosis diagnosis

There are many studies trying to find a mysterious gene that would solve all the mysteries of endometriosis, yet none have been identified up to now. In the study conducted by She et al, the authors revealed an R system modeling using artificial intelligence and literature-based gene data sets that covers a comparison of healthy and endometriosis diagnosed patients’ genes aiming to define a diagnostic system.  The researchers downloaded public datasets to the R package to obtain an annalistic profile…

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Endometriosis information coming from the social media

Today’s changing and evaluating world led everything to be lived online. For sure endometriosis and searching for cures or support for endometriosis have been transferred to online social media platforms too. The study conducted by Julian Matthias Metzler et al analyzed a 2-day snapshot view of Instagram and Facebook posts about endometriosis. The authors made a search on Facebook and Instagram using the words “endo” and “endometriosis” to reach out to the social media accounts using those names in a…

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It is all about awareness when it comes to endometriosis

Endometriosis and chronic pelvic pain are known to have debilitating effects on daily life, educational life, and work life. However, the true prevalence and effects of the disease data are still controversial all over the World. The survey-based study conducted in New Zealand by JordanTewhaiti‑Smith et al. questioned the population-based effects of endometriosis on daily life, personal relations, employment, and education. Basic demographic data, diagnostic timing, educational delay, work-related problems, social wellbeing, and recent prevalence of the disease have been…

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Blocking endometriosis through the inflammasomes

The medical treatment for endometriosis covers hormonal medications which prevent ovulation and fertility when on pills. In the study conducted by Murakami et al., a nonhormonal medication option has been evaluated for both blocking the endometriosis growth and also promoting the ovarian functions. As far as endometriosis is a well-known inflammatory disease, the authors worked on the level of inflammasomes and especially NLRP3, a known inflammasome in endometriosis. Twenty-five samples of endometriosis and matched eutopic endometrium tissues from patients with endometriosis;…

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The largest series of diaphragmatic endometriosis

Diaphragmatic endometriosis is one of the most common extra pelvic endometriosis types, yet the correct incidence is unclear. In the study conducted by Ceccaroni Marcello et al from the International School of Surgical Anatomy, Verona, Italy, the authors analyzed the data of 215 patients diagnosed with DE in the last 15 years. The lesion symptomatology of all patients, pelvic staging, DE lesion types, and type of surgeries applied were evaluated. For typing,  lesions were classified as “Foci” for bidimensional superficial…

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Urinary Tract Endometriosis

Endometriosis is mostly seen in patients of fertile age, and urinary tract endometriosis affects 1.2 to 6% of women with endometriosis. French coloRectal Infiltrating ENDometriosis Study (FRIENDS) group investigated the characteristics of urinary tract endometriosis in 232 patients from 31 centers. Authors found that total ureteral endometriosis and total bladder endometriosis are the most common locations. The results of this interesting study have recently been published in the European Journal of Obstetrics Gynecology and Reproductive Biology. The authors stated that 47.8% of…

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Egg or chicken, which is causing bladder symptoms, DIE or surgery for DIE?

Urinary symptoms could be overwhelming and sometimes could be hidden behind pain symptoms, but still might cause secondary damages on kidneys and bladder if remain undetected. In the prospective study conducted by Laterza et al, the authors questioned whether the overactive bladder is a case for patients who has DIE diagnosis and do not have urinary nodules and could be improved after surgery. Patients who have been operated on for DIE diagnosis and have overactive bladder symptoms (OAB), in two…

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Endometriosis: Beyond the naked eye visibility

The gold standard method for endometriosis diagnosis is histopathologic evaluation of the resected lesions. The study conducted by Sara-Michelle Gratton et al. in Canada evaluated the possible effect of developed laparoscopic skills and equipment on the endometriosis diagnosis, and whether it is possible to replace the histopathologic diagnosis. The charts of the patients who had operation in a tertiary endometriosis center in Canada. The charts of 96 patients with definitive explanations of endometriosis lesions, ASRM classification, and histopathologic confirmation have…

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Shining like fireflies: a new approach to visualize early endometriosis

Endometriosis is a complex and unsolved disease that requires animal studies in order to understand its nature. There are a group of animal models designed for endometriosis studies, but most require sacrificing the animal. In the experimental study designed by the team led by Tasuku Harada, the authors announced a novel animal model which would allow noninvasive monitoring of the lesions with the help of luciferase enzymes. Emerald luciferase vector is used to generate the transgenic mouse. After the vector creation, The uterine…

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Fertility Problems and Pregnancy Complications: Are They Coming From the Same Root Theory?

Endometriosis and adenomyosis are bad sisters causing not only infertility but also when pregnancy is achieved, complications related to the disease. In the review paper written by Gruber et al, it is described that adenomyosis and endometriosis come from the same root theory named "archimetrosis". The theory has been explained as a cessation of the junctional zone caused by microtraumas on the uterine lining leads to adenomyosis and endometriosis. Also, the complications are told to be related to the results of…

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To be or not to be [surgery or hormonal therapies for pain] that’s the question!

Deep infiltrative endometriosis is the most challenging type of endometriosis disease. Surgical management is the one that most surgeons prefer for dealing with, while it requires experience and usually causes complications related to the requirement of difficult operative techniques. Thus, it would be essential if a noninvasive option would be as effective as surgery. In the comparative retrospective annalistic study conducted by Rezende et al, the authors questioned whether hormonal medications alone or if continued after surgery, are as effective…

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Is it iron that calls vessels to form endometriosis

The trigger mechanism of endometriosis formation is still under investigation. But it is clear that there is an iron overload on endometriotic lesions. In the study conducted by Guojing Li et al, the mechanism of iron on endometriosis formation has been questioned. The researchers analyzed the effect of ferroptosis, a programmed cell death mechanism, on endometriosis formation and possible serving cytokines of this mechanism to promote endometriosis formation, and published their results in the journal Cell Death Discovery. Eutopic and ectopic…

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Machine learning tools to predict endometriosis

The current gold standard diagnostic method for endometriosis is the surgical diagnosis and yet no approaches have been found to replace it. In the study conducted by Sofiane Bendifallah et al, the authors aimed to use machine learning algorithms to give an opportunity for first step catch of the disease by general practitioners or even patients themselves. The data of 8000 patients, who are suspicious for endometriosis, on a national study platform have been analyzed. 6266 data have been excluded…

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What do endometriosis and ovarian cancer have in common?

While endometriosis is not a malignant disease, it is for sure known that it shares genetic disorders with cancers. In the bioinformatics study applied by Leyi Ni et al, the researchers analyzed the genetic pathways shared by both ovarian cancers and endometriosis to find out the paths showing endometriosis to cancer conversion. The keywords for “endometriosis” and “ovarian cancer” were searched in an online dataset for genes, named the GEO. Datasets for endometriosis, healthy human and ovarian cancer gene data were…

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Cancer invasion genes to explain invasiveness of adenomyosis

Adenomyosis looks similar to endometriosis, but it is not the same. However, the invasiveness and migration patterns of both diseases have something in common. The study conducted by Guo et al. questioned whether invasiveness genes that have already been studied in deep infiltrative endometriosis have also a role in adenomyosis formation. They have examined SKP2 and ZEB1 and their crossmatching roles on adenomyotic cell cultures. Endometriotic samples of patients who had a hysterectomy for adenomyosis and for subserosal myoma were…

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Vitamin A interrupts epithelial-mesenchymal transition in endometriosis

The mechanism underlying the endometriosis formation is still not clear. Recent studies are focusing on the effect of retinoic acid and IL6 on epithelial-to-mesenchymal transition (EMT). In the study conducted by Luyi Li et al, the researchers also questioned the relation between retinoic acid, IL-6, and EMT, in the paper published in "Annal of Palliative Medicine". Endometriosis samples were taken from the ovarian endometrioma operations, and control endometrial samples were obtained from the eutopic endometrium of patients without endometriosis. The…

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Indocyanin Green dye for recognition of occult endometriotic lesions

The surgery for endometriosis is challenging and the resection of all lesions is not accurately related to not catching all lesions under white light (WL) conventional laparoscopy. In the study conducted by Luigi Carlo Turco et al., in a tertiary endometriosis center, near-infrared (NIR) light was applied after intravenous indocyanine green (ICG) administration to evaluate whether this is a feasible method to be used to visualize occult endometriosis lesions. Fifty-one patients have been included in the study after 84 were…

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Herbicide Alters Immune System on the Route to Endometriosis

A popular environmental pollutant and herbicide named 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) and its receptor named aryl hydrocarbon receptor (AHR) have been suggested for causing endometriosis, but the mechanism was not clear. In the study conducted by  Mahsa Tanha et al, the researchers investigated the immunologic pathways that TCDD herbicide and its receptor AHR use to cause endometriosis. The study examined the peripheral blood samples from 24 women, half with histological confirmation for stage 4 endometriosis, and the rest have…

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Is it the new gold mine for endometriosis: oral GnRH antagonists

Progestins and combined oral contraceptive pills are the first step hormonal options for women with endometriosis. But the more the use expands the more cases are seen with resistance to progestins. This gave birth to a need for different therapeutic options. In the review summarized by Donnez et al., the use of oral GnRH antagonists on endometriosis has been analyzed. A literature search was done from PubMed and Embase including studies from 2010 to 2021. The keywords as ‘GnRH antagonist…

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The Epithelial–Mesenchymal Transition and IVF success

Endometriosis is a disease with lots of unknowns and one is that the reason for causing infertility. It is possible that a decrease in mitochondrial content may diminish oocyte quality in endometriosis. Furthermore, endometriosis alters the microenvironment of maturing oocytes that result in ovulatory dysfunction hence causing poor oocyte quality, diminished fertilization and implantation rates, low-grade embryos, underscoring the direct effect of endometriosis on the development of oocytes, embryos, and the receptivity of the endometrium. In the study led by Dr.…

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