Bahar Yuksel, MD

Bahar Yuksel graduated from Istanbul University Istanbul Medical School at the top of the class in 2010. She completed her residency in Istanbul Medical School Obstetrics and Gynecology Department with the top score Residency Board Exam. Between 2016 and 2017 she studied at Stanford School of Medicine and did research on ovarian physiology.  Her projects were funded by The Scientific And Technological Research Council Of Turkey several times. Her main interests are endometriosis and ovarian physiology. Now she has her practice in Istanbul as an associate professor in Ob&Gyn, cofounder of Endometriosis Research and Support Society, EndoTurkiye, and works for the Endometriosis Foundation of America (EndoFound.org) as Research Associate.

Machine learning based potential biomarkers

To explore potential biomarkers for an accurate diagnosis and treatment, and to elucidate the mechanism of endometriosis, Yi Huang et al, analyzed gene differences between eutopic and ectopic endometrium and the status of the immune microenvironment., and published their results in the scientific journal named "Frontiers in Endocrinology". A variety of machine learning algorithms were applied for feature selection to screen for diagnostic markers. From the public functional genomics database named Gene Omnibus, the endometriosis-related datasets were downloaded and DEGs between eutopic and ectopic endometrium…

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Predictability of IVF success by basal progesterone levels on patients with endometriosis

Endometriosis causes infertility in around 30-40% of all diagnosed women. Thus, strategies leading to more successful IVF results remain important. In the prospective study by Jovan Bila, the menstruation day 3 levels of serum progesterone were questioned to have a predictive value. Women younger than 40 years old, primarily infertile only related to endometriosis with no other factor and no gynecologic disease, have 3-15 antral follicles and have regular menses with normal BMI have enrolled prospectively in the study. All…

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Foreseeing what will be seen on laparoscopy

Endometriosis diagnosis still relies on preoperative prediction and its confirmation by taking biopsies. Thus, a prediction model for forecasting what would be waiting for the surgeon and the patient will be promising to get prepared.   In the study conducted by Yanhua Yang et al, the authors collected data from patients to find the correlation between preoperative evaluations and operative findings. The database included non-pregnant patients older than 18 years old; who have a normal hepatic and renal function; have undergone…

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Embryo implantation and endometriosis

Infertility is one of the main symptoms of endometriosis. And unfortunately, monthly fecundity rates decrease from 15% to 2-10% for women with endometriosis. The reason for these decreases is controversial and still not known whether it is because of impaired oocyte quality or endometrial receptivity. In the review conducted by Astrid Boucher et al, the main reasons are underlined. The PubMed database has been searched for the words “endometriosis” and “embryo implantation”, including studies published up to April 2022 and…

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Devilish triad: Endometriosis-irritable bowel syndrome and eating disorders

Most women with endometriosis report digestive symptoms. But it is not well-defined whether those are related to endometriosis itself or a secondary syndrome may be the cause. Irritable bowel syndrome, eating disorders, and anxiety are very commonly diagnosed diseases among women as well as endometriosis. In the study conducted in France by Alexandra Aupetit et al, the relationship between these disorders has been questioned. Patients between 18 and 50 years diagnosed with endometriosis in the last 4 years have been selected…

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Time to change out taboos about the radiologic evaluation of scar endometriosis

Scar endometriosis is one of the rare forms of endometriosis. According to traditional belief, it has always been evaluated radiologically on menstruation days. In the study conducted by Balaban et al, the authors compared the differences in lesions according to different phases of the menstrual period. A total of 24 excised and histologically confirmed cases of scar endometriosis have been evaluated with their preoperative radiologic findings. All lesions were checked by ultrasonography, color Doppler US, and sono-elastography by evaluating lesion…

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Is endometriosis an oxidative stress-induced inflammation?

The roots of endometriosis are still controversial, but the effects of inflammation and oxidative stress have been accepted by scientific authorities. In the review conducted by Lauren Clower et al, the studies about oxidative stress and endometriosis have been analyzed. The article was recently published in the journal Biomolecules. The analysis includes the current literature concerning oxidative stress in endometriosis, the mechanisms of endometriotic pain, and treatment suggestions to stop oxidative stress. The summary of the results that have been accepted…

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Turn around to come to the same spot: Nothing specific to predict AMH decline

Endometriomas are challenging lesions as they might cause a decline in ovarian function either only by their presence or related to their surgery. Thus, any preoperative parameter that might give a vision to a surgeon for postoperative results is crucial. In the prospective study conducted in Tehran by Maliheh Fakehi et al, the parameters related to endometrioma have been checked by multivariate analysis to examine the correlation between the postoperative AMH decline. Women between 18 to 44 years old who…

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A call for mast cells from endometriotic lesions

Endometriosis is a well-known hormonal-dependent inflammatory disease. But what type of inflammatory cells is responsible, and when does estrogen take part, are questions that have not been answered yet. In the study conducted by Alison McCallion et al, the role of mast cells and the underlying mechanisms are analyzed. The researchers have sought answers from endometriotic lesions, endometrial cell cultures, and mouse models of endometriosis. Endometrium, endometriosis tissue, and peritoneal fluid of 14 advanced stage endometriosis patients and 8 eutopic…

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The predictive value of operative findings concerning ovarian reserve

Having endometrioma is a proven factor that affects the ovarian reserve of patients with endometriosis. Not only its presence but also the surgery applied, and concomitant disease stage might affect the reserve. In this retrospective analysis conducted in Korea by Jisun Lee et al, the researchers questioned the factors affecting postoperative ovarian reserve on endometrioma surgery. They analyzed 112 patients with ovarian endometrioma who underwent ovarian cystectomy over a 7-year-old period. rASRM scores, depth, and size of the endometrioma, and extension…

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The effect of postoperative hormonal medication preferences on the recurrence rate of endometrioma

Endometrioma is the most investigated type of endometriosis. The recurrence after surgery is important regarding its and reoperation’s effect on ovarian functions. In the study conducted by Seung-Hye Choi et al, the researchers questioned the effect of different postoperative hormonal treatment modalities on endometrioma recurrence. Women who had planned endometrioma surgery at a single center between 2000 and 2020 have been included. The data of 372 women who had COC after GnRH agonist and 252 patients who used dienogest for…

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Start exercising for pain relief

Physical exercises have always been suggested for chronic pain-related diseases as well as endometriosis. However, the effect of exercise and the frequency that is effective on pain relief is unknown. In the study conducted by Ipek Ensari et al, a self-reported phone application program was used to analyze the daily bases symptoms and their changes after exercise were studied. The data was collected from a self-reports phone application program called Phendo where patients enter their surgery details, exercise, and pain…

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Estradiol metabolism, endometriosis and migraine

Endometriosis and migraine are the leading pain diseases of women of reproductive ages. As both are known to be induced by hormonal changes, in the review conducted by Joy-Fleur van der Vaart et al, the authors aimed to find out the overlapping polymorphisms on hormone receptor genes by searching the literature about migraine and endometriosis case studies. The PubMed database was searched for the studies published between 2000 and 2021 on gene polymorphism for endometriosis and migraine separately by using “endometriosis”…

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How to reduce follicle loss during endometrioma surgery?

Bilateral endometrioma is a critical situation to decide on further approaches when both infertility and pain are concerned. Techniques to protect ovarian functions are crucial when applying a cyst removal is inevitable. In the retrospective study conducted by Lingli Xin et al., the effects of vasopressin injection between cyst wall and ovarian tissue have been questioned in women with bilateral endometrioma. 122 patients who had regular menstrual periods have cysts larger than 5 cm, and who were not on any…

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Chasing gold to find endometriosis.

Endometriosis is a disease that doesn’t have a proper preoperative diagnostic test. Thus, animal models to study endometriosis are vital to show the effects of drugs and the effects of the disease on the body. In the study conducted by Ryan M. Marquardt et al, a mouse model of endometriosis has been designed by using silica-coated gold nanoparticles which allow noninvasive prediction and tracking of endometriotic lesions. The donor mice were injected with estradiol for 3 days, and after euthanasia,…

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The role of oxidative stress on endometriosis symptomatology

Endometriosis is not only a hormonal disease, but it is also an inflammatory illness provoked by hormones. In the review conducted by Hossein Ansariniya et al., from Iran, the relation between oxidative stress, free radicals, free iron, and the development of endometriotic lesions has been analyzed. By referring to the literature, the authors explained the role of oxidative stress molecules in endometriosis symptoms. The summary of their findings is listed as followings: Iron-induced oxidative stress provokes a set of reactions that…

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Endometrioma and its relation with fibrosis, dysmenorrhea, and AMH levels.

Endometrioma is an indicator of endometriosis which makes it easy to diagnose the disease for most clinicians. But the symptoms and relationship of endometrioma with menstrual pain severity and the ovarian reserve as well as its markers are not well known. In the study conducted by Jichan Nie et al., the authors questioned the relationship between ovarian fibrosis at the endometrioma site, the level of AMH levels, and the severity of dysmenorrhea. A total of 313 patients who underwent laparoscopic…

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A search for a marker to show the malignancy risk of endometriomas

The premalignant features and precursors that show the malignant potential in endometriomas are not well-known. In the systematic review conducted by Ludovica Bartiromo et al, the markers for malignant transformation have been analyzed and recently published in a recent issue of the International Journal of Molecular Sciences. In the literature review, databases have been checked for the keywords: “Endometriosis”, “Atypical”, “Atypical endometriosis”, “Marker”, “Biomarker”, and “Atypia”. Only full-length, English-written manuscripts, including the case reports and research papers, have been included. PRISMA criteria…

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The clearance system is defective for women who develop endometriosis

Endometriosis is both a hormonal and an immune disease thus overcoming the immune response by improving the underlying mechanism would help fight the disease. In the study conducted by Dr.Guidice group at the University of California San Francisco, San Francisco, CA, USA, the researchers analyzed the immune response distribution on endometrium and blood of healthy women and women with endometriosis. A total of 34 endometrial tissues (Control = 14, Endometriosis = 20) and a total of 60 blood samples (Control =9,…

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No way to sleep when you suffer from pain

Having chronic disease might alter the sleep quality and disturb sleeping periods. Besides insomnia, endometriosis itself changes the pain sensitivity and increases the body’s reaction to inflammatory and painful inputs. Thus, as a chronic and painful long-term situation, the relation between endometriosis and sleep disturbances is extremely important. In the study conducted by Ricardo José de Souza et al, the researchers conducted a prospective self-report-based survey to outline the relation between endometriosis-related pain levels and insomnia. Women between 18-50 years…

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