Bahar Yuksel, MD

Bahar Yuksel graduated from Istanbul University Istanbul Medical School at the top of the class of 2010. She completed her residency in Istanbul Medical School Obstetrics and Gynecology Department by the top score Residency Board Exam. Between 2016 and 2017 she studied at Stanford School of Medicine and did research about ovarian physiology.  Her projects were funded by The Scientific And Technological Research Council Of Turkey several times. Her main interests are endometriosis and ovarian physiology. Now she has her practice in Istanbul as an Ob&Gyn , member of Turkish Endometriosis and Adenomyosis Society and works for the Endometriosis Foundation of America (EndoFound.org) as Research Associate.

Resveratrol for endometriosis

Endometriosis has been studied previously about its inflammatory nature and its tendency for causing macrophage disfunction. In the study conducted by Chunyan Wang et al, the researchers analyzed the effect of a flavonoid, "resveratrol" on endometriosis lesions and the mechanism underlying these functions by applying RNAseq and transcriptomic analysis.  They studied female rats with an endometriosis autotransplantation model by applying resveratrol intraperitoneally for 28 days.  Mice were divided into 5 groups, endometriosis group, medium or high resveratrol dose groups, and…

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Improvement of sexual-life quality in patients with endometrioma

Endometriosis is a painful disease that affects daily life as well as sexual life quality. In the study conducted by Yalcin Bahat et al, the researchers questioned the effect of periodic use of dydrogesterone on the sexual life quality of patients with endometrioma. Dydrogesterone is synthetic progesterone, works similar to progesterone, and is used to treat menstrual disorders caused by a lack of hormones, relieve pain and menstrual cramps, and prevent miscarriages and abortions. The authors used VAS pain scores and female sexual function…

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Routine preoperative ureteral stent and complications in Deep Infiltrating Endometriosis

Deep infiltrative endometriosis is a devastating disease that includes both anterior and posterior compartments, and ureteral infiltration with endometriotic nodules affects 1 to 6% of all deep infiltrative endometriosis patients. In the study conducted by Giulia Borghese et al., the outcomes of prophylactic ureteral stent insertion have been investigated by comparing 2 groups, one with prophylactic stent and the second with the perioperative decision for the stent. The article has recently been published in the "International Journal of Gynaecology &…

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Small chain fatty acids produced by gut microbiota: Could that be the missing milestone for endometriosis

Endometriosis is a worldwide problem but still, the underlying mechanism and optimal treatment options are controversial. In the study conducted by Sangappa B Chadchan et al., the researchers investigated the possible relationship between gut microbiota and endometriosis. A study published in the journal "Life Science Alliance". The researchers used an endometriosis injection model of mice in order to compare the effect of different small chain fatty acids on endometriotic lesions. First, they produced endometriotic lesions on microbiota-depleted mice and measured the…

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Endometriosis: Beyond the naked eye visibility

The gold standard method for endometriosis diagnosis is histopathologic evaluation of the resected lesions. The study conducted by Sara-Michelle Gratton et al. in Canada evaluated the possible effect of developed laparoscopic skills and equipment on the endometriosis diagnosis, and whether it is possible to replace the histopathologic diagnosis. The charts of the patients who had operation in a tertiary endometriosis center in Canada. The charts of 96 patients with definitive explanations of endometriosis lesions, ASRM classification, and histopathologic confirmation have…

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A new "survey-based" endometriosis diagnostic tool

Endometriosis is a disease that is diagnosed years after its appearance which causes life quality impairment to patients. It is crucial for the patient to find out the probability of the presence of endometriosis, for applying to healthcare providers before it is too late. Thinking that "self-completed probability tests would improve diagnostic accuracy and lessen the years missed before diagnosis", a study conducted by Arnaud Fauconnier et al, using the French language accredited version of a questionnaire which was generated…

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Catching endometriosis from the front line: educating general practitioners

It should be repetitively pronounced that "endometriosis is very common and it is very important to diagnose it as soon as possible before it causes lifelong damage to women’s lives". The sooner the better concerning the diagnosis, and this is possible if the system is built to diagnose endometriosis by the front liners [general practitioners(GPs)]. The study conducted by Dr. Foulon's team in France questioned the effectiveness of GP knowledge on endometriosis. They have made a custom-built survey and reached…

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Outpatient neuromuscular protocol may improve the quality of life in women with chronic pelvic pain

Chronic pelvic pain syndrome is a complicated entity causing central and peripheric sensitization of nerves. The sensitization processes start a loop of unbreakable pain chain causing resistance to conventional therapy methods. The study conducted by Soha Patil et al covering data from 9 centers all around the USA has analyzed the effect of neuromuscular treatment approaches on the improvement of life quality of women with chronic pelvic pain. The authors have included 186 patients of whom 56 were diagnosed with endometriosis…

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The role of physical examination and interview in Endometriosis Diagnosis

Today we know that the most accurate diagnosis of endometriosis necessitates surgery and histopathological examination of the excised lesions. However, many women are misdiagnosed due to various symptoms of endometriosis which mystify gastrointestinal, urinary, and musculoskeletal diseases. Nawrocka-Rutkowska and colleagues investigated the importance and accuracy of interview and physical examination for the diagnosis of endometriosis. The results were recently published in the "International Journal of Environmental Research and Public Health". The authors analyzed data from 148 patients who underwent laparoscopic…

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Urinary Tract Endometriosis

Endometriosis is mostly seen in patients of fertile age, and urinary tract endometriosis affects 1.2 to 6% of women with endometriosis. French coloRectal Infiltrating ENDometriosis Study (FRIENDS) group investigated the characteristics of urinary tract endometriosis in 232 patients from 31 centers. Authors found that total ureteral endometriosis and total bladder endometriosis are the most common locations. The results of this interesting study have recently been published in the European Journal of Obstetrics Gynecology and Reproductive Biology. The authors stated that 47.8% of…

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Not just the pain stops but also the bowel function improves after DIE surgery

Bowel endometriosis and the techniques to operate it have always been a challenge. The study conducted by Beraldo et al., from Brazil, highlighted the results of an effective nerve-sparing bowel surgery on endometriosis lesions and its long-term effects on patients. The results were recently published in the journal named "Diseases of the Colon & Rectum". The authors have included 37 patients who had undergone surgery by the same team and evaluated their preoperative and postoperative long-term results by using Low Anterior…

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It is not that simple: endometriomas are almost never alone

Endometriomas are the widely and easily diagnosed type of endometriosis. They are usually treated by gynecologic surgeons and are thought to be alone most of the time. The study conducted by Piriyev et al highlighted the coexistence of extraovarian endometriosis associated with endometriomas. The authors found only 2.3% of all endometriomas could be without any concomitant extraovarian endometriosis lesions. While 80.6% of all patients had peritoneal endometriosis and 43.2% had deep infiltrating endometriosis, 38% of patients had both lesions together with…

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Postoperative Opioid use after Robotic operations for endometriosis, compared to non-endometriosis

Endometriosis is a common disease in patients of fertile age, and many patients require surgery. Robotic surgery is accepted as a minimally invasive method in the management of endometriosis and other benign conditions. However, postoperative pain status and the best pain relief option after robotic endometriosis surgery have not been optimized yet. Delgado and colleagues analyzed the post-operative pain status and opioid requirement in 119 patients who underwent robotic endometriosis surgery and compared the results with those from 39 patients who…

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Predictors for achieving pregnancy in patients with adenomyosis and endometriosis

Adenomyosis and endometriosis are benign conditions, however, both situations are associated with deterioration of life quality, a requirement of hospital administrations, and infertility. Laparoscopic surgery is the main treatment option especially for women who desire pregnancy. Shi and colleagues aimed to clarify possible factors for achieving successful birth following laparoscopic surgery in patients with coexisting adenomyosis and endometriosis. The authors divided patients into two groups according to achieving successful birth; and found that the patients who had successful delivery following…

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Ultrasonographic signs of adenomyosis, surgery and infertility in endometriosis patients

Adenomyosis is simply defined as the presence of endometrial glands and stroma within the uterine myometrium and is related to severe menstrual bleeding, pain, and infertility. Previous reports demonstrated the coexisting of endometriosis and adenomyosis is common. In the present study, Dr. Eisenberg group investigated the differences of transvaginal ultrasonographic findings of patients for coexisting adenomyosis in endometriosis patients who underwent conservative management and laparoscopic surgery, and predictive factors for infertility. The results were recently published in the "Journal of…

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Women reject using hormonal drugs for endometriosis, an accelerating need for nonhormonal medications

Although the pathophysiology of endometriosis is poorly understood, endocrine drugs are widely used for reducing inflammation and patients’ symptoms. Burla and colleagues aimed to evaluate the patients’ thoughts and expectations about the endocrine drugs which are used in the treatment of endometriosis and analyzed a total of 1420 patients’ answers to their survey. Results showed that 57.5% of patients with endometriosis currently using hormonally active drugs to treat endometriosis and combined oral contraceptives (80%) were the most common among them.…

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Patient- centeredness in endometriosis

Endometriosis is common in fertile age, and women with endometriosis are suffering from serious symptoms including pelvic discomfort, dysmenorrhea, and infertility. Due to resemblances of endometriosis symptoms with other diseases, most endometriosis patients are faced with delays in diagnosis. To solve these problems, patient-centered modality is accepted and questionnaires were formed to understand endometriosis better. The ENDOCARE questionnaire was previously described and validated to understand endometriosis patients’ characteristics, but the Swedish version of it has not been validated yet. Grundström and…

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Vulvo- Perineal Endometriosis: From diagnosis to treatment

Vulvo- Perineal endometriosis is a very rare condition that should be kept in mind to be diagnosed and treated. Due to its very rare occurrence, most of the information in the literature on vulvo-perineal endometriosis is based on case reports and studies with a small number of patients. Miallard and colleagues reviewed 90 articles including 83 case reports and seven retrospective studies, reporting a total of 283 patients.  Authors concluded that 95.3% of patients with vulvo-perineal endometriosis had a history…

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The effect of COVID-19 pandemic on patients with endometriosis

COVID-19 pandemic and related conditions, including transport restrictions, social isolation, and difficulties accessing the professional health system, affected many women’s healthcare and daily routine. Evans and colleagues investigated the impact of COVID-19 and COVID-19 related parameters on endometriosis patients’ health situation and their daily functioning. Patients who participated in a previous study via e-mail in 2019, invited to participate in the present study, and the study link was sent via email for the 12-month survey in June 2020. The authors…

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Endometriosis alters women’s self-behavior

Endometriosis diagnosis is given to almost 15% of women of reproductive age. Although endometriosis could be asymptomatic, many women with endometriosis are faced with several symptoms including chronic pelvic pain, dysmenorrhea, dyspareunia, dyschezia, dysuria, and infertility. The wide variability of symptoms resulting in delayed diagnosis and optimal treatment deteriorate patients’ quality of life. To investigate the effect of endometriosis on womens’ behavior, Estes and colleagues, reviewed the database of Clinformatics® Data Mart (Optum, Inc. Eden Prairie, Minnesota) which includes almost…

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