Bahar Yuksel, MD

Bahar Yuksel graduated from Istanbul University Istanbul Medical School at the top of the class of 2010. She completed her residency in Istanbul Medical School Obstetrics and Gynecology Department by the top score Residency Board Exam. Between 2016 and 2017 she studied at Stanford School of Medicine and did research about ovarian physiology.  Her projects were funded by The Scientific And Technological Research Council Of Turkey several times. Her main interests are endometriosis and ovarian physiology. Now she has her practice in Istanbul as an Ob&Gyn , member of Turkish Endometriosis and Adenomyosis Society and works for the Endometriosis Foundation of America (EndoFound.org) as Research Associate.

A call for mast cells from endometriotic lesions

Endometriosis is a well-known hormonal-dependent inflammatory disease. But what type of inflammatory cells is responsible, and when does estrogen take part, are questions that have not been answered yet. In the study conducted by Alison McCallion et al, the role of mast cells and the underlying mechanisms are analyzed. The researchers have sought answers from endometriotic lesions, endometrial cell cultures, and mouse models of endometriosis. Endometrium, endometriosis tissue, and peritoneal fluid of 14 advanced stage endometriosis patients and 8 eutopic…

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The predictive value of operative findings concerning ovarian reserve

Having endometrioma is a proven factor that affects the ovarian reserve of patients with endometriosis. Not only its presence but also the surgery applied, and concomitant disease stage might affect the reserve. In this retrospective analysis conducted in Korea by Jisun Lee et al, the researchers questioned the factors affecting postoperative ovarian reserve on endometrioma surgery. They analyzed 112 patients with ovarian endometrioma who underwent ovarian cystectomy over a 7-year-old period. rASRM scores, depth, and size of the endometrioma, and extension…

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The effect of postoperative hormonal medication preferences on the recurrence rate of endometrioma

Endometrioma is the most investigated type of endometriosis. The recurrence after surgery is important regarding its and reoperation’s effect on ovarian functions. In the study conducted by Seung-Hye Choi et al, the researchers questioned the effect of different postoperative hormonal treatment modalities on endometrioma recurrence. Women who had planned endometrioma surgery at a single center between 2000 and 2020 have been included. The data of 372 women who had COC after GnRH agonist and 252 patients who used dienogest for…

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Start exercising for pain relief

Physical exercises have always been suggested for chronic pain-related diseases as well as endometriosis. However, the effect of exercise and the frequency that is effective on pain relief is unknown. In the study conducted by Ipek Ensari et al, a self-reported phone application program was used to analyze the daily bases symptoms and their changes after exercise were studied. The data was collected from a self-reports phone application program called Phendo where patients enter their surgery details, exercise, and pain…

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Estradiol metabolism, endometriosis and migraine

Endometriosis and migraine are the leading pain diseases of women of reproductive ages. As both are known to be induced by hormonal changes, in the review conducted by Joy-Fleur van der Vaart et al, the authors aimed to find out the overlapping polymorphisms on hormone receptor genes by searching the literature about migraine and endometriosis case studies. The PubMed database was searched for the studies published between 2000 and 2021 on gene polymorphism for endometriosis and migraine separately by using “endometriosis”…

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How to reduce follicle loss during endometrioma surgery?

Bilateral endometrioma is a critical situation to decide on further approaches when both infertility and pain are concerned. Techniques to protect ovarian functions are crucial when applying a cyst removal is inevitable. In the retrospective study conducted by Lingli Xin et al., the effects of vasopressin injection between cyst wall and ovarian tissue have been questioned in women with bilateral endometrioma. 122 patients who had regular menstrual periods have cysts larger than 5 cm, and who were not on any…

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Chasing gold to find endometriosis.

Endometriosis is a disease that doesn’t have a proper preoperative diagnostic test. Thus, animal models to study endometriosis are vital to show the effects of drugs and the effects of the disease on the body. In the study conducted by Ryan M. Marquardt et al, a mouse model of endometriosis has been designed by using silica-coated gold nanoparticles which allow noninvasive prediction and tracking of endometriotic lesions. The donor mice were injected with estradiol for 3 days, and after euthanasia,…

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The role of oxidative stress on endometriosis symptomatology

Endometriosis is not only a hormonal disease, but it is also an inflammatory illness provoked by hormones. In the review conducted by Hossein Ansariniya et al., from Iran, the relation between oxidative stress, free radicals, free iron, and the development of endometriotic lesions has been analyzed. By referring to the literature, the authors explained the role of oxidative stress molecules in endometriosis symptoms. The summary of their findings is listed as followings: Iron-induced oxidative stress provokes a set of reactions that…

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Endometrioma and its relation with fibrosis, dysmenorrhea, and AMH levels.

Endometrioma is an indicator of endometriosis which makes it easy to diagnose the disease for most clinicians. But the symptoms and relationship of endometrioma with menstrual pain severity and the ovarian reserve as well as its markers are not well known. In the study conducted by Jichan Nie et al., the authors questioned the relationship between ovarian fibrosis at the endometrioma site, the level of AMH levels, and the severity of dysmenorrhea. A total of 313 patients who underwent laparoscopic…

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A search for a marker to show the malignancy risk of endometriomas

The premalignant features and precursors that show the malignant potential in endometriomas are not well-known. In the systematic review conducted by Ludovica Bartiromo et al, the markers for malignant transformation have been analyzed and recently published in a recent issue of the International Journal of Molecular Sciences. In the literature review, databases have been checked for the keywords: “Endometriosis”, “Atypical”, “Atypical endometriosis”, “Marker”, “Biomarker”, and “Atypia”. Only full-length, English-written manuscripts, including the case reports and research papers, have been included. PRISMA criteria…

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The clearance system is defective for women who develop endometriosis

Endometriosis is both a hormonal and an immune disease thus overcoming the immune response by improving the underlying mechanism would help fight the disease. In the study conducted by Dr.Guidice group at the University of California San Francisco, San Francisco, CA, USA, the researchers analyzed the immune response distribution on endometrium and blood of healthy women and women with endometriosis. A total of 34 endometrial tissues (Control = 14, Endometriosis = 20) and a total of 60 blood samples (Control =9,…

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No way to sleep when you suffer from pain

Having chronic disease might alter the sleep quality and disturb sleeping periods. Besides insomnia, endometriosis itself changes the pain sensitivity and increases the body’s reaction to inflammatory and painful inputs. Thus, as a chronic and painful long-term situation, the relation between endometriosis and sleep disturbances is extremely important. In the study conducted by Ricardo José de Souza et al, the researchers conducted a prospective self-report-based survey to outline the relation between endometriosis-related pain levels and insomnia. Women between 18-50 years…

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Preoperative detailed ultrasound is effective for the prediction of surgical extent.

Endometriosis surgery is like opening the box of pandora when you start the surgery. A preoperative guide is extremely important for the surgeon to draw a road map. In the study conducted by Alessandra Di Giovanni et al, the effectiveness of preoperative advanced transvaginal sonography has been questioned as to be a preoperative lead for the surgeon by comparing with perioperative ENZIAN classification.  Ninety-six women who had preoperative transvaginal ultrasonography and then had deep infiltrating endometriosis surgeries during 2019 have…

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Genetic prediction models for endometriosis diagnosis

There are many studies trying to find a mysterious gene that would solve all the mysteries of endometriosis, yet none have been identified up to now. In the study conducted by She et al, the authors revealed an R system modeling using artificial intelligence and literature-based gene data sets that covers a comparison of healthy and endometriosis diagnosed patients’ genes aiming to define a diagnostic system.  The researchers downloaded public datasets to the R package to obtain an annalistic profile…

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Endometriosis information coming from the social media

Today’s changing and evaluating world led everything to be lived online. For sure endometriosis and searching for cures or support for endometriosis have been transferred to online social media platforms too. The study conducted by Julian Matthias Metzler et al analyzed a 2-day snapshot view of Instagram and Facebook posts about endometriosis. The authors made a search on Facebook and Instagram using the words “endo” and “endometriosis” to reach out to the social media accounts using those names in a…

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It is all about awareness when it comes to endometriosis

Endometriosis and chronic pelvic pain are known to have debilitating effects on daily life, educational life, and work life. However, the true prevalence and effects of the disease data are still controversial all over the World. The survey-based study conducted in New Zealand by JordanTewhaiti‑Smith et al. questioned the population-based effects of endometriosis on daily life, personal relations, employment, and education. Basic demographic data, diagnostic timing, educational delay, work-related problems, social wellbeing, and recent prevalence of the disease have been…

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Blocking endometriosis through the inflammasomes

The medical treatment for endometriosis covers hormonal medications which prevent ovulation and fertility when on pills. In the study conducted by Murakami et al., a nonhormonal medication option has been evaluated for both blocking the endometriosis growth and also promoting the ovarian functions. As far as endometriosis is a well-known inflammatory disease, the authors worked on the level of inflammasomes and especially NLRP3, a known inflammasome in endometriosis. Twenty-five samples of endometriosis and matched eutopic endometrium tissues from patients with endometriosis;…

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The largest series of diaphragmatic endometriosis

Diaphragmatic endometriosis is one of the most common extra pelvic endometriosis types, yet the correct incidence is unclear. In the study conducted by Ceccaroni Marcello et al from the International School of Surgical Anatomy, Verona, Italy, the authors analyzed the data of 215 patients diagnosed with DE in the last 15 years. The lesion symptomatology of all patients, pelvic staging, DE lesion types, and type of surgeries applied were evaluated. For typing,  lesions were classified as “Foci” for bidimensional superficial…

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Urinary Tract Endometriosis

Endometriosis is mostly seen in patients of fertile age, and urinary tract endometriosis affects 1.2 to 6% of women with endometriosis. French coloRectal Infiltrating ENDometriosis Study (FRIENDS) group investigated the characteristics of urinary tract endometriosis in 232 patients from 31 centers. Authors found that total ureteral endometriosis and total bladder endometriosis are the most common locations. The results of this interesting study have recently been published in the European Journal of Obstetrics Gynecology and Reproductive Biology. The authors stated that 47.8% of…

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Egg or chicken, which is causing bladder symptoms, DIE or surgery for DIE?

Urinary symptoms could be overwhelming and sometimes could be hidden behind pain symptoms, but still might cause secondary damages on kidneys and bladder if remain undetected. In the prospective study conducted by Laterza et al, the authors questioned whether the overactive bladder is a case for patients who has DIE diagnosis and do not have urinary nodules and could be improved after surgery. Patients who have been operated on for DIE diagnosis and have overactive bladder symptoms (OAB), in two…

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