Kasthuri Nair

Kasthuri is currently pursuing a Bachelors of Science in Molecular and Cellular Biology at Johns Hopkins University. She has a passion for medical writing that was first ignited in 2015 and hopes to pursue a career in medical journalism. 

Is the Endometriosis Fertility Index Reliable?

Zhang et al. recently published a paper titled “Prediction of Endometriosis Fertility Index in patients with endometriosis-associated infertility after laparoscopic treatment” in Reproductive BioMedicine Online. The research group from the West China Second University Hospital in Sichuan University wanted to analyze the Endometriosis Fertility Index (EFI) and its predictive value. The main function of the EFI is to predict spontaneous conception after surgery. The researchers recruited women with endometriosis-related infertility who were undergoing laparoscopic treatment. These women underwent surgery and…

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Extending the Female Fertility Clock

Varela, Sanchez-de-Puerta, and Garcia-Velasco are a group of scientists from various institutions in Spain and they recently published a review article titled “Fertility, IVF and reproductive genetics” in Current Opinion in Obstetrics and Gynecology. In this publication, the authors discussed recent research pertaining to the impact telomere biology had on ovarian aging and female fertility. More specifically, the authors looked at telomere shortening, the wearing down of the telomere, and telomere dysfunction. The researchers dedicated a section of the article…

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S100A6 May be a Promising Target for Endometriosis Treatments

Peng et al., a group primarily from the Zhejiang University Medical College, recently published a paper in Gynecological Endocrinology titled “Upregulation of S100A6 in patients with endometriosis and its role in ectopic endometrial stromal cells.” This paper delineates a study that sought to understand the role of S100 calcium-binding protein A6 (S100A6) in endometriosis disease progression. The researchers paid particular attention to S100A6 expression in women with endometriosis and looked at potential functional roles played by S100A6 in ectopic endometrial…

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HOXA10: A Culprit in Endometriosis Disease Progression

Zheng et al., a group of authors from the Aerospace Center Hospital in Bejing and from the First Affiliated Hospital of Wenzhou Medical University in Wenzhou, recently published a paper in Reproductive Sciences entitled “Decreased Expression of HOXA10 May Activate the Autophagic Process in Ovarian Endometriosis.” The authors wanted to see if the Homeobox A10 (HOXA10) gene plays a role in endometriosis disease progression by negatively regulating autophagy. In the same vein, the authors wanted to elucidate the exact mechanism regulating…

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Most Effective Embryo Transfer Strategy

Bourdon et al., a group of scientists mainly from the Centre Hospitalier Universitaire, recently published a paper in PLOS ONE titled “The deferred embryo transfer strategy improves cumulative pregnancy rates in endometriosis-related infertility: A retrospective matched cohort study.” This study wanted to compare cumulative assisted reproduction technology (ART) outcomes in women with endometriosis who undergo fresh and deferred frozen-thawed embryo transfer (Def-ET). The researchers recruited and matched women with endometriosis who are scheduled for a fresh-ET cycle with those scheduled…

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Highlights Thoracic Endometriosis Case

Dr. Tamer Seckin, MD, the co-founder of the Endometriosis Foundation of America, was recently featured in a New York Times article titled “The Woman Was Fit and Healthy. Why Did Her Lung Mysteriously Collapse?” The article describes a rather unusual and rare case of endometriosis that presents with a collapsed lung. The patient had a collapsed lung that was initially diagnosed as spontaneous pneumothorax; however, her lungs collapsed multiple times after the initial incident disproving the first diagnosis. The patient…

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No Link Found Between Vitamin D and Endometriosis

Buggio et al., a group of scientists from the Ospedale Maggiore Policlinico, Universita` degli Studi in Milan, recently published a paper in the Reproductive Sciences titled “25-Hydroxyvitamin D Serum Levels and Endometriosis: Results of a Case-Control Study.” The publication sought to analyze vitamin D levels in women with and without endometriosis because it was previously thought that this prohormone may help endometriosis disease progression. As endometriosis is a multifactorial disease and the dysfunction of the immune system which may be responsible…

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Endometriosis From an Epigenetic Lens

Samadieh et al. from the Royan Institute for Reproductive Biomedicine, recently published an article in Reproductive Sciences titled “Epigenetic Dynamics of HOXA10 Gene in Infertile Women With Endometriosis.” In this paper, the researchers wanted to observe HOXA10 gene expression in the eutopic and ectopic endometrium of women with endometriosis. They wanted to see how certain epigenetic marks, like MeCP2, which play a role in the regulatory region of gene promoter, affect HOXA10 gene expression. The study had 2 groups, an experimental group…

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Picture This: 8K UHD Television System for Endometriosis Surgery

This case report by Aoki et al. was published in the journal "Videosurgery and Other Miniinvasive Techniques" under the title “Effect of an 8K ultra-high-definition television system in a case of laparoscopic gynecologic surgery.” In this publication, the authors delineated a case study they hoped would highlight the benefits of using an 8K ultra-high-definition television system. In this particular case, the new system was used during a laparoscopic gynecologic surgery for endometriosis, and the results were compared with that yielded…

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Mechanism for Migration of Endometriosis Cells in the Body

Li et al. recently published a paper in Stem Cells titled “Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis.” This article seeks to understand the mechanisms underlying the migration of endometriosis. The authors initially hypothesize that endometriosis-derived mesenchymal stem cells (MSCs) can travel through the circulatory system. This mechanism allows the creation of new lesions and enables the interactions between distant pre-existing endometriosis. The researchers used mouse models to establish experimental endometriosis in mice. They collected blood from these mice, subjected to…

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Adolescents with Endometriosis are More Susceptible to Migraines

Miller et al. recently published an article titled “The prevalence of migraines in adolescents with endometriosis” in Fertility and Sterility. The main purpose of the study was to determine if adolescents with endometriosis experience more migraines than those without endometriosis. The researchers also wanted to analyze pelvic pain in adolescents with endometriosis who are also suffering from migraines. There were two groups of participants in the study. One group consisted of adolescent females with surgically diagnosed endometriosis. The other group,…

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Endometriosis can Adversely Affect Oocyte Quality

Kasapoglu et al. recently published a study in Gynecological Endocrinology titled “Detrimental effects of endometriosis on oocyte morphology in intracytoplasmic sperm injection cycles: a retrospective cohort study.” In this paper, they compared the oocytes recovered from women who have endometriosis with women whose partners suffer from male factor infertility. The retrieved oocytes were evaluated for morphological abnormalities and fertilization outcomes. The study consisted of 2 groups: an experimental group and a control group. The experimental group was comprised of women…

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An Unusual Case "Free Floating Omental Endometrioma"

Capaccione et al. published an article in Radiology Case Reports titled “Massive endometrioma presenting with dyspnea and abdominal symptoms.” This publication is centered around a particularly unique case report of a woman who was ultimately diagnosed with endometriosis. The patient of interest is a 29-year-old woman with a history of chronic gastroesophageal reflux disease and chronic dysmenorrhea. She has also had a Helicobacter pylori-negative gastric ulcer. She came to her primary physician with the following symptoms: abdominal tension, shortness of…

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A How-To Guide for Endometriosis Surgery

The European Society for Gynaecological Endoscopy (ESGE), ESHRE, and the World Endometriosis Society (WES) recently published a document titled “Recommendations for the surgical treatment of endometriosis—part 1: ovarian endometriomas.” This publication provides surgeons with recommendations for the technical aspects of different surgeries used to treat endometriosis. This publication focuses on women with endometriosis who wish to get pregnant at a later date. This guidebook was created by a working group and is based on expert opinion. The authors recommend that…

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Menstrual Effluent Can Change the Future of Endometriosis

During Endometriosis Awareness Month, Warren et al. published a paper entitled “Analysis of menstrual effluent: diagnostic potential for endometriosis” in Molecular Medicine. This paper relies heavily on the theory of retrograde menstruation, where menstrual effluent flows into the peritoneal cavity. It is thought that retrograde menstruation is a factor that eventually leads to endometriosis. The authors of this study wanted to examine the diagnostic potential of ME-derived stromal fibroblast cells (SFCs). They also looked towards ME-derived cells as a tool…

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Ectopic Pregnancy Risk Factors

Jacob, Kalder, and Kostev recently published an article titled “Risk factors for ectopic pregnancy in Germany: a retrospective study of 100,197 patients” in German Medical Science. The retrospective German study hoped to elucidate the risk factors for ectopic pregnancies. The participants of the study included 3,003 women with ectopic pregnancy and 97,194 women without ectopic pregnancy. The researchers found these participants in the databases of 262 different gynecological practices. The participants were analyzed for various clinical and demographic variables. A…

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The Past, Present, and Future of Diagnosing Endometriosis

This review titled “Endometriosis: Epidemiology, Diagnosis and Clinical Management” published in Current Obstetrics and Gynecology Reports examines the distribution and factors associated with endometriosis. The analysis by Parasar, Ozcan, and Terry also delineates potential biomarkers and risk factors that could be used to diagnose and treat the disease effectively. The authors begin the review by discussing the presentation and clinical course of endometriosis. Endometriosis presents itself differently in different patients, and that can make it difficult to diagnose and classify.…

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The Challenging Path to Diagnosis

Kallia O. Wright, a professor at Illinois College, recently published her essay titled “You have Endometriosis”: Making Menstruation Related Pain Legitimate in a Biomedical World” in Health Communication. This essay delineates the author’s experience with endometriosis. The author started experiencing pain during mensuration after puberty. Her pain was often ignored or made fun of. Additionally, many people, loved ones included, would say that the pain would go away if she just embraced traditional gender roles and started a family. This…

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Hair Cortisol Levels are Higher in Women Suffering from Endometriosis

Aken et al. recently published a piece in Psychoneuroendocrinology titled “Hair cortisol and the relationship with chronic pain and quality of life in endometriosis patients.” This publication discussed a study that analyzed hair cortisol levels in women with and without endometriosis. Hair cortisol levels are indicative of chronic cortisol concentrations, which are further illustrative of individual stress levels. The researchers wanted to discern a link between chronic pain symptoms, health-related quality of life (HRQoL), and hair cortisol levels in women suffering from endometriosis. The…

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Which Endometriosis Treatment is Better: NETA or Extended-cycle OC (Seasonique®)?

Scala et al. recently shared the findings of their patient preference prospective study in a journal article titled “Norethindrone acetate versus extended-cycle oral contraceptive (Seasonique®) in the treatment of endometriosis symptoms: A prospective open-label comparative study,” which was published in the European Journal of Obstetrics & Gynecology and Reproductive Biology in 2018. The article compares extended-cycle oral contraception (OC) with norethindrone acetate (NETA). The dependent variable in their study was patient satisfaction. It is important to note that all the participants…

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