Kasthuri Nair

Kasthuri is currently pursuing a Bachelors of Science in Molecular and Cellular Biology at Johns Hopkins University. She has a passion for medical writing that was first ignited in 2015 and hopes to pursue a career in medical journalism. 

A Doctor's Guide to Making Endometriosis Less Scary

Canis, Bourdel, and Chauvet, doctors from CHU Estaing, recently published an article titled “Endometriosis: frightening the patients is not an acceptable alternative to inadequate surgical management and or pathophysiology ignorance” in Fertility and Sterility. Their paper delineated proper health practices that will alleviate or avoid unnecessary stress on patients suffering from endometriosis. The authors discuss surgery as a possible option for endometriosis care. They caution against improper pre- and post-surgical discussions that can cause undue stress on the patient. These…

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Alternative Solutions: Neuromuscular Electrical Stimulation for Endometriosis Pain

Bi and Xie, researchers from The Yan’an People’s Hospital, recently published the results of their retrospective study titled “Effect of neuromuscular electrical stimulation for endometriosis-associated pain” in Medicine. The study hoped to elucidate the effects of using a complementary and alternative medicine, namely neuromuscular electrical stimulation (NMES), for the treatment of endometriosis-associated pain (EAP). There were 83 patients with EAP in the treatment group and these participants underwent NMES therapy. There were 71 patients with EAP in the control group…

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Key to Understanding Ovarian Endometriosis may lay in the Peptides

Xue et al. recently published a paper titled “Peptidomic Analysis of Endometrial Tissue from Patients with Ovarian Endometriosis” in Cellular Physiology and Biochemistry. The research group from various departments of Nanjing Medical University wished to better understand the pathogenesis of Ovarian endometriosis (OvE).  The researchers collected ectopic and eutopic endometria tissue samples from 3 women with OvE, identified and quantified the peptides, and then they investigated the functions of various peptide protein precursors using bioinformatics assays. They also obtained, cultured,…

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Effectiveness of the Endometriosis Symptom Diary

Seitz et al., a research group from Bayer AG and the University of Giessen, recently published an article titled “Patterns of missing data in the use of the endometriosis symptom diary” in BMC Women's Health. The authors were analyzing data from the VALEPRO study. The study used an electronic patient-reported outcome (ePRO) instrument called the Endometriosis Symptom Diary (ESD). The researchers from this study looked for patterns of missing data and wanted to elucidate the factors that led to the…

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Fallopian Tube Capability in Women with Pelvic Endometriosis and Adenomyosis

Xia et al. recently published a paper titled “Effects of pelvic endometriosis and adenomyosis on the ciliary beat frequency and muscular contractions in the human fallopian tube” in Reproductive Biology and Endocrinology. This research group primarily from Shanghai Jiaotong University conducted a study that assessed the fallopian tube transport capacity in women who suffer from Pelvic endometriosis (EM) and adenomyosis (AM). Transport capability of the Fallopian tube was to be measured using ciliary beat frequency (CBF) and tubal smooth muscle…

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Catching Endometriosis Early

Li et al., a group primarily from Sun Yat-sen University in the People’s Republic of China, recently published an article titled “Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages” in Reproductive Biology and Endocrinology. The paper addresses the lack of an optimal diagnostic tool for individuals with minimal-mild stage endometriosis. The researchers used ultra-high-performance liquid chromatography alongside electrospray ionization high-resolution mass spectrometry (UHPLC-ESI-HRMS) in order to discover differences in the eutopic endometrium metabolomic profile in…

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Potential Study: Can Omega-3 purified Fatty Acids Treat Endometriosis Pain?

Abokhrais et al. published a paper titled “A pilot randomized double-blind controlled trial of the efficacy of purified fatty acids for the treatment of women with endometriosis-associated pain (PurFECT): study protocol” in Pilot and Feasibility Studies. The aforementioned authors are primarily from the University of Edinburgh. Their article delineates a procedure that could be potentially be used to test the effectiveness of Omega-3 purified fatty acids (PUFA) for the purpose of addressing endometriosis pain. The study discussed in this article…

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Difficulties Associated with Diagnosing Ascites and Encapsulating Peritonitis in Endometriosis

De Magalhães et al. recently published a paper titled “Ascites and Encapsulating Peritonitis in Endometriosis: a Systematic Review with a Case Report” in Revista Brasileira de Ginecologia e Obstetrícia. The team from the Universidade Federal do Ceará and the Universidade de Fortaleza wanted to increase awareness of a unique presentation of endometriosis, namely overt ascites and peritonitis. Over the course of the article, the authors discuss their systematic review and delineate a case seen at the author’s institution. For the…

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Abnormal Regulation of Pathways Seen in Endometriosis

Sikora et al., a team from the Medical University of Silesia in Katowice, published a study in the Archives of Gynecology and Obstetrics titled “The role of complement components C1q, MBL and C1 inhibitor in the pathogenesis of endometriosis.” It has been said that complement system disorders and endometriosis disease progression may be linked. The paper focused on the complement system components C1q, mannose-binding lectin (MBL), and C1 inhibitor (C1INH) in order to affirm or reject the previous statement. In endometriosis, one of the most important…

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Deep Infiltrating Endometriosis Impairs Sexual Function

Lima et al., a group of scientists from Hospital do Servidor Público Estadual in Brazil, recently published an article entitled “Female Sexual Function in Women with Suspected Deep Infiltrating Endometriosis” in Revista Brasileira De Ginecologia E Obstetricia. The paper analyzed sexual function quality in females suffering from suspected deep infiltrating endometriosis (DIE). The researchers recruited 67 sexually active female patients with suspected or diagnosed DIE. The researchers collected certain key pieces of information from each of the participants. The participant’s…

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Is the Endometriosis Fertility Index Reliable?

Zhang et al. recently published a paper titled “Prediction of Endometriosis Fertility Index in patients with endometriosis-associated infertility after laparoscopic treatment” in Reproductive BioMedicine Online. The research group from the West China Second University Hospital in Sichuan University wanted to analyze the Endometriosis Fertility Index (EFI) and its predictive value. The main function of the EFI is to predict spontaneous conception after surgery. The researchers recruited women with endometriosis-related infertility who were undergoing laparoscopic treatment. These women underwent surgery and…

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Extending the Female Fertility Clock

Varela, Sanchez-de-Puerta, and Garcia-Velasco are a group of scientists from various institutions in Spain and they recently published a review article titled “Fertility, IVF and reproductive genetics” in Current Opinion in Obstetrics and Gynecology. In this publication, the authors discussed recent research pertaining to the impact telomere biology had on ovarian aging and female fertility. More specifically, the authors looked at telomere shortening, the wearing down of the telomere, and telomere dysfunction. The researchers dedicated a section of the article…

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S100A6 May be a Promising Target for Endometriosis Treatments

Peng et al., a group primarily from the Zhejiang University Medical College, recently published a paper in Gynecological Endocrinology titled “Upregulation of S100A6 in patients with endometriosis and its role in ectopic endometrial stromal cells.” This paper delineates a study that sought to understand the role of S100 calcium-binding protein A6 (S100A6) in endometriosis disease progression. The researchers paid particular attention to S100A6 expression in women with endometriosis and looked at potential functional roles played by S100A6 in ectopic endometrial…

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HOXA10: A Culprit in Endometriosis Disease Progression

Zheng et al., a group of authors from the Aerospace Center Hospital in Bejing and from the First Affiliated Hospital of Wenzhou Medical University in Wenzhou, recently published a paper in Reproductive Sciences entitled “Decreased Expression of HOXA10 May Activate the Autophagic Process in Ovarian Endometriosis.” The authors wanted to see if the Homeobox A10 (HOXA10) gene plays a role in endometriosis disease progression by negatively regulating autophagy. In the same vein, the authors wanted to elucidate the exact mechanism regulating…

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Most Effective Embryo Transfer Strategy

Bourdon et al., a group of scientists mainly from the Centre Hospitalier Universitaire, recently published a paper in PLOS ONE titled “The deferred embryo transfer strategy improves cumulative pregnancy rates in endometriosis-related infertility: A retrospective matched cohort study.” This study wanted to compare cumulative assisted reproduction technology (ART) outcomes in women with endometriosis who undergo fresh and deferred frozen-thawed embryo transfer (Def-ET). The researchers recruited and matched women with endometriosis who are scheduled for a fresh-ET cycle with those scheduled…

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Highlights Thoracic Endometriosis Case

Dr. Tamer Seckin, MD, the co-founder of the Endometriosis Foundation of America, was recently featured in a New York Times article titled “The Woman Was Fit and Healthy. Why Did Her Lung Mysteriously Collapse?” The article describes a rather unusual and rare case of endometriosis that presents with a collapsed lung. The patient had a collapsed lung that was initially diagnosed as spontaneous pneumothorax; however, her lungs collapsed multiple times after the initial incident disproving the first diagnosis. The patient…

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No Link Found Between Vitamin D and Endometriosis

Buggio et al., a group of scientists from the Ospedale Maggiore Policlinico, Universita` degli Studi in Milan, recently published a paper in the Reproductive Sciences titled “25-Hydroxyvitamin D Serum Levels and Endometriosis: Results of a Case-Control Study.” The publication sought to analyze vitamin D levels in women with and without endometriosis because it was previously thought that this prohormone may help endometriosis disease progression. As endometriosis is a multifactorial disease and the dysfunction of the immune system which may be responsible…

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Endometriosis From an Epigenetic Lens

Samadieh et al. from the Royan Institute for Reproductive Biomedicine, recently published an article in Reproductive Sciences titled “Epigenetic Dynamics of HOXA10 Gene in Infertile Women With Endometriosis.” In this paper, the researchers wanted to observe HOXA10 gene expression in the eutopic and ectopic endometrium of women with endometriosis. They wanted to see how certain epigenetic marks, like MeCP2, which play a role in the regulatory region of gene promoter, affect HOXA10 gene expression. The study had 2 groups, an experimental group…

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Picture This: 8K UHD Television System for Endometriosis Surgery

This case report by Aoki et al. was published in the journal "Videosurgery and Other Miniinvasive Techniques" under the title “Effect of an 8K ultra-high-definition television system in a case of laparoscopic gynecologic surgery.” In this publication, the authors delineated a case study they hoped would highlight the benefits of using an 8K ultra-high-definition television system. In this particular case, the new system was used during a laparoscopic gynecologic surgery for endometriosis, and the results were compared with that yielded…

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Mechanism for Migration of Endometriosis Cells in the Body

Li et al. recently published a paper in Stem Cells titled “Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis.” This article seeks to understand the mechanisms underlying the migration of endometriosis. The authors initially hypothesize that endometriosis-derived mesenchymal stem cells (MSCs) can travel through the circulatory system. This mechanism allows the creation of new lesions and enables the interactions between distant pre-existing endometriosis. The researchers used mouse models to establish experimental endometriosis in mice. They collected blood from these mice, subjected to…

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