Özge Özkaya, PhD

Özge has a Phd in Molecular Biology and several years experience working as a bench scientists. She has been working in science communication since 2014.

Could Endometriosis Be Caused by Bacteria?

A new concept called the bacterial contamination hypothesis in endometriosis has been proposed for the first time by researchers in Japan. This means that new potential therapies approaches could exist for this condition in addition to the conventional estrogen-suppressing therapies. The team led by Dr. Jo Kitawaki at the Kyoto Prefectural University of Medicine in Japan measured the levels of endotoxin in the menstrual blood and peritoneal fluid, of women with and without endometriosis. Endotoxins are toxic substance released by…

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Increasing IVF Success Rates

DuoStim or double ovarian stimulation is the most promising approach to increase the number of eggs collected to be used in IVF, according to a review article published in the journal Current Opinion in Obstetrics and Gynecology.  Pain and infertility are common features of endometriosis and research have shown that 35 to 50 percent of women with endometriosis are infertile. IVF may be an option for women with endometriosis who cannot get pregnant naturally, but the technique is not always…

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How Does Endometriosis Affect the Sexual Satisfaction of Men?

Although the majority of men whose partner has endometriosis are satisfied or very satisfied with their sexual relationship, the proportion of men who are not sexually satisfied is higher among those whose partner has endometriosis compared to those whose partner does not have endometriosis. This according to a study by researchers in Switzerland who analyzed almost 500 couples. The results were published in the Journal of Sexual Medicine. According to the authors of the study, these findings stress the importance of…

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miRNAs, Could Be a Reliable Biomarker of Endometriosis

miRNAs, small pieces of genetic material found in the blood could be used as a reliable marker to diagnose endometriosis, according to a study by U.S. researchers. They could also be used to follow the progression of the disease and measure how well it responds to treatment. Being able to monitor the natural behavior of endometriosis and to understand how well a certain therapy works, are of great importance to improve patient care. This research shows that serum miRNAs could…

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Treatment of Endometriosis in Adolescents

Most women with endometriosis who have been treated with Lupron plus add back as adolescents felt the treatment was effective in reducing the pain caused by the condition, according to a study published in the Journal of Pediatric & Adolescent Gynecology. Moreover, most of them would recommend the treatment to others despite the side effects, the study found. Lupron is a gonadotropin-releasing hormone agonist (GnRHa) that provides pain relief and reduces the size of endometriosis lesions. To investigate the tolerability…

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"New Pain Dairy" Could Help Better Evaluate the Impact of Endometriosis on Women’s Daily Lives

Researchers developed a new patient-reported endometriosis pain daily diary.  The diary can help evaluate endometriosis-related pain and the impacts this can have on patients' lives as well as be used in clinical trials to assess patients’ response to treatment. “The [diary] represents an important step in providing an effective [patient-reported outcome] to evaluate pain associated with endometriosis and its related impacts on patients,” the researchers wrote in their article that was published in the journal Health and Quality of Life…

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The Long-Term Effect of Endometriosis

Women with endometriosis have a decreased pain tolerance even after fertile age and therefore require long-term treatment and psychological support Endometriosis has a long-term effect on the pain tolerance of women, suggests a study published in The Journal of Pain. It is therefore of great importance to provide these women with adequate psychological support and medical treatment even after their fertile years. The findings also suggest that delaying the diagnosis of endometriosis may lead to increased pain sensitization. So diagnosing…

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The Chance of Getting Pregnant of a Woman with Endometriosis May Soon Be Predictable

Researchers have found a new way of predicting whether or not an embryo will be able to successfully implant into the womb of a woman with endometriosis. These findings could make it possible to predict whether she is likely to become pregnant either naturally or following assisted reproductive treatments. The predictor in question is the level of so-called natural killer (NK) cells in the uterus. NK cells are types of specialized immune cells that play a crucial role in eliminating…

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Does Endometriosis Cause Infertility?

Infertility may be related to the localization of endometriosis involvement according to a study published in the Journal of Obstetrics and Gynaecology. This finding is in agreement with the results of previous studies and could help clinicians in their decision making about the treatment of infertile women with a diagnosis of endometriosis. To better analyze the relationship between pelvic pain, infertility, and the localization of endometriosis lesions, a team of researchers from Iran assessed the prevalence of endometriosis in 430…

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Another Marker to Predict the Outcome of IVF for Women with Endometriosis

AOPPs or advanced oxidative protein products may be new markers to predict egg quality and the outcomes of IVF in infertile women with endometriosis according to a study published in the journal Experimental and Therapeutic Medicine. This finding suggests that anti-oxidative treatments that can reduce the levels of AOPPs may potentially be used as a treatment to increase egg quality and IVF success rates. Oxidative stress is an imbalance between free radicals (also called reactive oxygen species or ROS) that are produced…

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Restricting Calorie Intake Could Delay or Prevent Endometriosis

Reducing the intake of calories could stop the development of endometriosis according to research conducted in mice. This could be the case even after the lesions are established, i.e. endometriosis has started. Dietary supplements or drug candidates that mimic the beneficial effects of restricting calories may have the same effect. Many studies have shown that reducing calorie intake by 30 to 40 percent without causing deficiencies of any specific nutrients, can prolong lifespan, reduce tumor growth and spread, and delay…

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Potential New Target to Treat Endometriosis?

Special cells called myeloid-derived suppressor cells (MDSC) could be playing a role in the development of endometriosis, suggests a study published in the European Journal of Immunology.  These cells could, therefore, be targeted by novel therapeutic agents to treat endometriosis.  MDSCs are a group of cells that originate from bone marrow stem cells. (Stem cells are unspecialized cells that can differentiate and give rise to any cell type in the body). MDSCs are cells that are still immature and that…

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Endometriosis Costs the Economy Almost $15,000 a Year per Patient

Patients with endometriosis incur significantly higher healthcare costs compared to other patients, a found a study published in the scientific journal Advances in Therapy. Because over 10 million women in the U.S. and an estimated 200 million women worldwide have endometriosis, the disease constitutes a substantial burden on healthcare systems and society. In order to measure the direct and indirect cost of endometriosis, researchers at AbbVie, Truven Health Analytics, and Colorado Center for Reproductive Medicine conducted a retrospective cohort study.…

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Can Getting Pregnant Make my Pain Go Away?

The association between pregnancy and symptoms of endometriosis are controversial and strongly biased, and there is no evidence suggesting that pregnancy reduces the size and number of endometriotic lesions, according to a study published in the journal Human Reproduction Update. Women should therefore not be advised that getting pregnant could help manage the symptoms of the disease and reduce its progression, according to the authors of the study. They should also not stop being evaluated periodically or taking any medical…

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Switching to a Low-Cost Progestin May Help Reduce Endo Pain When Oral Contraceptives Won’t Work

The majority of women with endometriosis-associated pain were satisfied to have switched to a treatment with norethisterone acetate or NETA, a synthetic, orally active progestin, when their oral contraceptive was ineffective, found a study published in the journal Reproductive Sciences. According to the authors, this finding could be used to counsel women with symptomatic endometriosis not responding to treatment with oral contraceptives and inform their decisions on modifications of disease management. To assess whether it was worthwhile to shift to a…

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Endometriosis “Changes” the Brain

Endometriosis changes the electrical properties of the brain as well as gene expression, according to a study by Yale researchers. These changes increase sensitivity to pain, anxiety, and depression. “While medications can be used to treat endometriosis directly, the effects on the brain are largely ignored,” the researchers wrote. They added that genes that are differentially expressed in endometriosis could constitute a target for potential treatments that could cure pain and control emotional disorders causing by endometriosis.  Endometriosis is a…

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Skin Endo Diagnosis

High-frequency ultrasound can be very useful for the early diagnosis of cutaneous endometriosis according to a study published in the journal Skin Research and Technology. The diagnostic tool could be used in patients who have unusual cyclical pain even before skin lesions appear. Cutaneous endometriosis is very rare. It is endometriosis that occurs in the skin usually in within scar tissue from previous surgery or injury. In the present study, researchers led by Dr. J.L. Perrot at the University Hospital…

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Citrus Fruits May Reduce the Risk of Endometriosis

Eating more fruits, and especially citrus fruits like oranges, and grapefruit may lower the risk of a woman developing endometriosis, found a study published in the scientific journal Human Reproduction. In contrast, some vegetables may increase the risk of the condition. Very few studies have examined the association between the consumption of fruit and vegetables and the risk of endometriosis to date. To better decipher this relationship, a group of researchers from the U.S. analyzed data collected from 70,835 women…

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Reason Why Hormone Therapy Alone Cannot Cure Endometriosis Uncovered

Researchers in Belgium have shed light on why hormone therapy cannot cure endometriosis on its own in a study published in the scientific journal Gynecological Endocrinology.  Their findings could shape the direction of future research and may help to find a cure for this complex condition. Hormone therapy is being used by a large number of women with endometriosis to relieve pain. However, it is known that this is not a cure for the condition and that different women with…

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Endometriosis Impacts Many Aspects of a Woman’s Life

Endometriosis has a severe negative impact not only on the physical health of a woman but also on other aspects of her life including optimism and self-esteem. This is according to an Australian study published in the Journal Healthcare for Women International.  This is especially the case for younger women (below the age of 25) who reported inferior outcomes about relationships, social wellbeing, and future life plans. Based on these findings, the authors of the study recommend health providers and…

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