Özge Özkaya, PhD

Özge has a Phd in Molecular Biology and several years experience working as a bench scientists. She has been working in science communication since 2014.

KEYNOTE: Excision Without Mutilation: It’s Possible! -  Arnaud Wattiez, MD

In his keynote lecture, Dr. Wattiez talks about the pros and cons of endometriosis surgery and the importance of tailoring endometriosis surgery to individual patients.  “Endometriosis is a disease that degrades patient’s wellbeing," Dr. Wattiez says and gives some examples of the disease’s negative impact on patients’ quality of life. According to Wattiez, 84% of women with endometriosis have a decrease in the quality of their work, one in five report being temporarily disabled, and 40% have their career growth…

Key Points Lay Summary

Exploring the Role of Neuropathy in Re-Operative Endometriosis - Marc Possover, MD, PhD

Prof. Possover starts his presentation by summarizing the possible cause of pelvic neuropathy following endometriosis surgery. Pelvic neuropathy is the damage or dysfunction of the pelvic nerve. Prof. Possover explained that this could either be due to incomplete surgery, disease recurrence, or actual damage to the pelvic nerves during endometriosis surgery.  He then talks about the functions of the pelvic nerve including urinary function, rectal function, sexuality, and leg movement describing the role of both the efferent nerve fibers or…

Key Points Lay Summary

Operative techniques for Deep Endometriosis Surgery - Shaheen Khazali, MD

In this presentation, Dr. Shaheen Khazali, an endometriosis surgeon specialized in gastrointestinal and urinary tract endometriosis excision and in neuropelveology, talks about the general principles and some techniques for endometriosis surgery focusing on rectovaginal endometriosis. He also describes the "ten rules of endometriosis surgery". According to Dr. Khazali, the fundamentals of endometriosis surgery are the same as any other surgery and anatomical knowledge is key. “We need to know our anatomy and revise even when you have been doing this…

Key Points Lay Summary

Egg Freezing for Endometriosis: Should she rush - Tomer Singer, MD

In this presentation, Dr. Tomer Singer, a fertility specialist and the medical director at Shady Grove Fertility in Manhattan, New York talks about egg freezing and its importance for women with endometriosis. He emphasizes the importance of having an endometriosis surgeon and reproductive endocrinologist who work together when caring for a woman with endometriosis. He moves on to explain the process of egg freezing stating that it is very similar to in vitro fertilization (IVF) minus the sperm.  It involves consultation…

Key Points Lay Summary

Role of Prophylactic Oophorectomy in Endometriosis Patients with Ovarian Cancer History in the family - Farr Nezhat, MD

Dr. Nezhat starts his presentation by outlining his objectives, which are to review the basics of cancer genetics, give an overview about endometriosis and ovarian cancer, discuss the pathogenesis of malignant transformation of endometriosis, and talk about the clinical implications of endometriosis. He first talks about the factors that can lead to cancer and germline and somatic mutations that can lead to cancer. He then moves onto the characteristics of endometriosis and talks about the common characteristics between endometriosis and…

Key Points Lay Summary

Endometriosis: Less is better. How to improve the integration between surgical and medical therapy - Errico Zupi, MD

In this presentation, Dr. Errico Zupi, Associate Professor in the Department of Obstetrics and Gynecology at the University of Rome talks about the importance of an integrative approach comprising of both medical and surgical interventions to treat endometriosis.  "The first step is an accurate preoperative diagnosis", Dr. Zupi says and adds that in the past there was a lot of confusion about the best possible method but that currently non-invasive imaging, not laparoscopic surgery, is the best approach. According to Dr.…

Key Points Lay Summary

Urological Challenges in Endometriosis Surgery - Guenter Noe, MD

In this presentation, Dr. Guenter Noé, Head of Department of Rheilandklinikum Dormagen in Germany talks about endometriosis affecting the urinary tract. Dr. Noé starts by describing the different parts of the urinary tract that can be affected by endometriosis including the kidneys, ureter, bladder, and urethra.  Dr. Noé then talks about the approaches that can be used to diagnose urinary endometriosis including physical examination, a transvaginal ultrasound, magnetic resonance imaging, and cystectomy. He stresses the importance of having clinicians specializing…

Key Points Lay Summary

Could Cosmetics and Personal Care Products Increase the Risk of Endometriosis?

The use of cosmetics and personal care products may be increasing the risk of endometriosis according to a study by Spanish researchers that was published in the journal "Environmental Research". This finding suggests that restricting the use of these products may help reduce the risk of endometriosis. This is important since there is currently no cure for the disease and the available treatments are only targeted at reducing the symptoms. In order to explore the relationship between the use of cosmetics…

Key Points Lay Summary

Endometriosis and Inflammation: How to Treat it?

Women with endometriosis have systemic and localized inflammation within eutopic and ectopic endometrial tissues found in a study published in the "American Journal of Reproductive Immunology". More importantly, the study also found that the inflammation caused by the disease could be reduced using hormonal therapy. This finding could change the lives of women affected by this debilitating disease causing infertility and chronic pain. It is already known that inflammation plays a key role in endometriosis. However, it is not clear…

Key Points Lay Summary

New Signaling Pathway Could Be Crucial in the Development of Endometriosis

RAMP1 signaling is crucial for growth and blood and lymphatic vessel formation in endometrial tissue, according to a new study published in the Journal of Cellular and Molecular Medicine. This suggests that blocking RAMP1 could be a new way to treat the disease. Using a mouse model of endometriosis, researchers in Japan demonstrated that the neuropeptide calcitonin gene-related peptide (CGRP) and its receptor, Receptor Activity-Modifying Protein 1 (RAMP 1) are crucial for the growth of endometrial tissue.  Neuropeptides are small…

Key Points Lay Summary

A new Marker to Detect Endometriosis and Its Severity?

Macrophage migration inhibitory factor (MIF) could be a novel marker that could help diagnose endometriosis as well as to detect its severity. This is according to a new study by researchers in Egypt, published in the scientific journal "BMC Women’s Health". There are currently no reliable markers that can detect endometriosis in a non-invasive method and laparoscopic surgery remains the gold-standard diagnostic tool. However, this is an invasive method that requires surgical incisions to be made. Macrophage migration inhibitory factor, MIF,…

Key Points Lay Summary

Assessment of Reproductive Health for Women With Endometriosis

Researchers in Iran developed a new and reliable patient-generated instrument to measure the reproductive health of women with endometriosis. Health providers as well as researchers can use the questionnaire to better understand the impact of the disease on women’s reproductive health over time and better meet their needs. Endometriosis affects many dimensions of reproductive health in affected women including physical, psychological, and sexual function. This is the first instrument that measures reproductive health in women with the disease. Researchers used a…

Key Points Lay Summary

Sexual Quality of Life in Women With Endometriosis

Painful intercourse, more severe period pain, worse health-related quality of life, and unemployment are all associated with worse sexual quality of life in women with endometriosis. This is according to a Dutch study published in the scientific journal Sexual Medicine. Being aware of these factors can help clinicians better address any issues related to the sexual quality of life.  The findings of this study also underscore the potential usefulness of the five-item sexual intercourse sub-scale of the endometriosis health profile-30…

Key Points Lay Summary

Effect of Endometriosis on IVF Success Rates

Endometriosis lowers the rate of cumulative live births during in vitro fertilization (IVF). However, this is due to a lower number of embryos being available for transplantation rather than their quality. This is according to a study published in the "Journal of Clinical Medicine". Cumulative live birth rate reflects the chance of getting pregnant over many IVF cycles as opposed to each cycle.  In this study, Dr. Boucret et al. sought to understand the impact of endometriosis on IVF success rates…

Key Points Lay Summary

New Rat Model of Endometriosis Could Help Researchers Develop New Treatments for the Condition

Researchers in Belgium developed a new rat model of endometriosis. The animals showed signs of ongoing pain meaning that the model could provide a tool for researchers to develop potential new ways to treat the different symptoms of the condition including chronic pelvic pain. Endometriosis is a deliberating condition affecting approximately one in 10 women of fertile age. Chronic pelvic pain, one of the symptoms of the disease, badly affects the quality of life of affected women. Currently available treatments…

Key Points Lay Summary

The Impact of Painful Sex on the Physical and Mental Wellbeing of Adolescent and Young Adult Women

Clinicians should ask adolescents and young women about painful sex, not just talk about contraception and the prevention of sexually transmitted diseases. This is because painful sexual intercourse could have a negative impact on relationships and peer engagement, which is very important for the formation of identity during adolescence.  According to a study published in the Journal of Adolescent Health, painful sexual intercourse impacts adolescents and young adult women both with and without endometriosis. This has a negative effect on…

Key Points Lay Summary

Is Endometriosis More Common Among Women of Certain Race/Ethnicity?

Race/ethnicity seems to have an influence on the prevalence of endometriosis with black women appearing to be less likely to be diagnosed with the disease compared to white women. However, other factors such as access and response to treatment may also influence the rate of "endometriosis" diagnosis. Understanding whether the prevalence of endometriosis really does differ between racial/ethnic groups can improve the ability of doctors to provide a timely and accurate diagnosis to all women and improve patient care. In…

Key Points Lay Summary

A New Treatment Approach for Endometriosis?

A new approach may be effective at relieving pain associated with endometriosis according to a study published in the PM&R Journal. The new technique may also improve “overall pelvic function, particularly in relation to intercourse, working, and sleeping,” according to the authors.  This new method involves pelvic-floor musculature trigger-point injections and peripheral nerve hydrodissection.  Trigger point injection is usually used to treat muscle pain as well as fibromyalgia and tension headaches. Small amounts of anesthetic and steroid are injected into the…

Key Points Lay Summary

Cabergoline or Progesterone not Effective in Rat Model of Endometriosis

Oral treatment with cabergoline or micronized progesterone for four weeks is not effective in the regression of endometriotic implants in a rat model of the disease. This is according to a study published in the "Journal of Investigative Surgery".  Cabergoline is a compound that mimics the action of the signaling molecule dopamine. It also inhibits the formation of new blood vessels, a biological event that is important for the development of endometriosis.  Micronized progesterone is progesterone that has been modified…

Key Points Lay Summary

Endometriosis Diagnosis in White, Black, and Asian Women

In a commentary published in the "International Journal of Obstetrics and Gynaecology", Drs. Farland and Horne talk about a study by researchers in Canada and the Philippines, which found that black women are less likely, and Asian women are more likely to be diagnosed with endometriosis compared to white women. According to Drs. Farland and Horne, there are many unanswered questions regarding this disparity in diagnosis. For example, it is not clear whether these associations are the result of diagnostic bias or…

Key Points Lay Summary