Özge Özkaya, PhD

Özge has a Phd in Molecular Biology and several years experience working as a bench scientists. She has been working in science communication since 2014.

Perineal Endometriosis, How Soon Does it Return After Surgery?

The higher the body mass index (BMI) of a woman during delivery and within one month after delivery, the quicker the symptoms of perineal endometriosis return. This is according to a recent study that appeared in the World Journal of Clinical Cases. Based on this finding, the authors stress the importance of evaluating the location of endometrial lesions before surgery and recommend immediate surgery following a diagnosis of perineal endometriosis.  Perineal endometriosis is a rare form of endometriosis where hard…

Key Points Lay Summary

Selected Blood Inflammatory Biomarkers May Help Identify Endometriosis

Levels of inflammatory biomarkers in the blood differ between women with endometriosis and those without the disease. Levels of some biomarkers also differ according to the stage of endometriosis. This is according to a new study by Polish scientists published in the "International Journal of Molecular Sciences". Based on this finding, the researchers propose a panel of inflammatory biomarkers that could be used to identify women with advanced-stage endometriosis who could qualify for treatment. It is already known that endometriosis…

Key Points Lay Summary

Endometriosis and Sexual Satisfaction

Endometriosis affects the ability to have an orgasm during sexual intercourse, according to a study published in The Journal of Sexual Medicine. However, the disease does not have an effect on reaching orgasm via masturbation or sexual activities with a partner that does not involve intercourse. These findings suggest that women living with chronic pelvic pain due to endometriosis could increase their sexual satisfaction by integrating activities in their sex lives that do not involve intercourse. Painful intercourse is one…

Key Points Lay Summary

Do Adolescents Know About Endometriosis?

Most secondary school girls have painful periods and many of them don’t know what typical periods are like, according to a study published in the "Journal of Pediatric and Adolescent Gynecology".  The majority of the girls do not have knowledge of endometriosis, although they are familiar with other chronic conditions such as diabetes and epilepsy. This finding is important and suggests that menstrual health education at school is important to improve knowledge about what a typical period is like, how to…

Key Points Lay Summary

KEYNOTE: Excision Without Mutilation: It’s Possible! -  Arnaud Wattiez, MD

In his keynote lecture, Dr. Wattiez talks about the pros and cons of endometriosis surgery and the importance of tailoring endometriosis surgery to individual patients.  “Endometriosis is a disease that degrades patient’s wellbeing," Dr. Wattiez says and gives some examples of the disease’s negative impact on patients’ quality of life. According to Wattiez, 84% of women with endometriosis have a decrease in the quality of their work, one in five report being temporarily disabled, and 40% have their career growth…

Key Points Lay Summary

Exploring the Role of Neuropathy in Re-Operative Endometriosis - Marc Possover, MD, PhD

Prof. Possover starts his presentation by summarizing the possible cause of pelvic neuropathy following endometriosis surgery. Pelvic neuropathy is the damage or dysfunction of the pelvic nerve. Prof. Possover explained that this could either be due to incomplete surgery, disease recurrence, or actual damage to the pelvic nerves during endometriosis surgery.  He then talks about the functions of the pelvic nerve including urinary function, rectal function, sexuality, and leg movement describing the role of both the efferent nerve fibers or…

Key Points Lay Summary

Operative techniques for Deep Endometriosis Surgery - Shaheen Khazali, MD

In this presentation, Dr. Shaheen Khazali, an endometriosis surgeon specialized in gastrointestinal and urinary tract endometriosis excision and in neuropelveology, talks about the general principles and some techniques for endometriosis surgery focusing on rectovaginal endometriosis. He also describes the "ten rules of endometriosis surgery". According to Dr. Khazali, the fundamentals of endometriosis surgery are the same as any other surgery and anatomical knowledge is key. “We need to know our anatomy and revise even when you have been doing this…

Key Points Lay Summary

Egg Freezing for Endometriosis: Should she rush - Tomer Singer, MD

In this presentation, Dr. Tomer Singer, a fertility specialist and the medical director at Shady Grove Fertility in Manhattan, New York talks about egg freezing and its importance for women with endometriosis. He emphasizes the importance of having an endometriosis surgeon and reproductive endocrinologist who work together when caring for a woman with endometriosis. He moves on to explain the process of egg freezing stating that it is very similar to in vitro fertilization (IVF) minus the sperm.  It involves consultation…

Key Points Lay Summary

Role of Prophylactic Oophorectomy in Endometriosis Patients with Ovarian Cancer History in the family - Farr Nezhat, MD

Dr. Nezhat starts his presentation by outlining his objectives, which are to review the basics of cancer genetics, give an overview about endometriosis and ovarian cancer, discuss the pathogenesis of malignant transformation of endometriosis, and talk about the clinical implications of endometriosis. He first talks about the factors that can lead to cancer and germline and somatic mutations that can lead to cancer. He then moves onto the characteristics of endometriosis and talks about the common characteristics between endometriosis and…

Key Points Lay Summary

Endometriosis: Less is better. How to improve the integration between surgical and medical therapy - Errico Zupi, MD

In this presentation, Dr. Errico Zupi, Associate Professor in the Department of Obstetrics and Gynecology at the University of Rome talks about the importance of an integrative approach comprising of both medical and surgical interventions to treat endometriosis.  "The first step is an accurate preoperative diagnosis", Dr. Zupi says and adds that in the past there was a lot of confusion about the best possible method but that currently non-invasive imaging, not laparoscopic surgery, is the best approach. According to Dr.…

Key Points Lay Summary

Urological Challenges in Endometriosis Surgery - Guenter Noe, MD

In this presentation, Dr. Guenter Noé, Head of Department of Rheilandklinikum Dormagen in Germany talks about endometriosis affecting the urinary tract. Dr. Noé starts by describing the different parts of the urinary tract that can be affected by endometriosis including the kidneys, ureter, bladder, and urethra.  Dr. Noé then talks about the approaches that can be used to diagnose urinary endometriosis including physical examination, a transvaginal ultrasound, magnetic resonance imaging, and cystectomy. He stresses the importance of having clinicians specializing…

Key Points Lay Summary

Could Cosmetics and Personal Care Products Increase the Risk of Endometriosis?

The use of cosmetics and personal care products may be increasing the risk of endometriosis according to a study by Spanish researchers that was published in the journal "Environmental Research". This finding suggests that restricting the use of these products may help reduce the risk of endometriosis. This is important since there is currently no cure for the disease and the available treatments are only targeted at reducing the symptoms. In order to explore the relationship between the use of cosmetics…

Key Points Lay Summary

Endometriosis and Inflammation: How to Treat it?

Women with endometriosis have systemic and localized inflammation within eutopic and ectopic endometrial tissues found in a study published in the "American Journal of Reproductive Immunology". More importantly, the study also found that the inflammation caused by the disease could be reduced using hormonal therapy. This finding could change the lives of women affected by this debilitating disease causing infertility and chronic pain. It is already known that inflammation plays a key role in endometriosis. However, it is not clear…

Key Points Lay Summary

New Signaling Pathway Could Be Crucial in the Development of Endometriosis

RAMP1 signaling is crucial for growth and blood and lymphatic vessel formation in endometrial tissue, according to a new study published in the Journal of Cellular and Molecular Medicine. This suggests that blocking RAMP1 could be a new way to treat the disease. Using a mouse model of endometriosis, researchers in Japan demonstrated that the neuropeptide calcitonin gene-related peptide (CGRP) and its receptor, Receptor Activity-Modifying Protein 1 (RAMP 1) are crucial for the growth of endometrial tissue.  Neuropeptides are small…

Key Points Lay Summary

A new Marker to Detect Endometriosis and Its Severity?

Macrophage migration inhibitory factor (MIF) could be a novel marker that could help diagnose endometriosis as well as to detect its severity. This is according to a new study by researchers in Egypt, published in the scientific journal "BMC Women’s Health". There are currently no reliable markers that can detect endometriosis in a non-invasive method and laparoscopic surgery remains the gold-standard diagnostic tool. However, this is an invasive method that requires surgical incisions to be made. Macrophage migration inhibitory factor, MIF,…

Key Points Lay Summary

Assessment of Reproductive Health for Women With Endometriosis

Researchers in Iran developed a new and reliable patient-generated instrument to measure the reproductive health of women with endometriosis. Health providers as well as researchers can use the questionnaire to better understand the impact of the disease on women’s reproductive health over time and better meet their needs. Endometriosis affects many dimensions of reproductive health in affected women including physical, psychological, and sexual function. This is the first instrument that measures reproductive health in women with the disease. Researchers used a…

Key Points Lay Summary

Sexual Quality of Life in Women With Endometriosis

Painful intercourse, more severe period pain, worse health-related quality of life, and unemployment are all associated with worse sexual quality of life in women with endometriosis. This is according to a Dutch study published in the scientific journal Sexual Medicine. Being aware of these factors can help clinicians better address any issues related to the sexual quality of life.  The findings of this study also underscore the potential usefulness of the five-item sexual intercourse sub-scale of the endometriosis health profile-30…

Key Points Lay Summary

Effect of Endometriosis on IVF Success Rates

Endometriosis lowers the rate of cumulative live births during in vitro fertilization (IVF). However, this is due to a lower number of embryos being available for transplantation rather than their quality. This is according to a study published in the "Journal of Clinical Medicine". Cumulative live birth rate reflects the chance of getting pregnant over many IVF cycles as opposed to each cycle.  In this study, Dr. Boucret et al. sought to understand the impact of endometriosis on IVF success rates…

Key Points Lay Summary

New Rat Model of Endometriosis Could Help Researchers Develop New Treatments for the Condition

Researchers in Belgium developed a new rat model of endometriosis. The animals showed signs of ongoing pain meaning that the model could provide a tool for researchers to develop potential new ways to treat the different symptoms of the condition including chronic pelvic pain. Endometriosis is a deliberating condition affecting approximately one in 10 women of fertile age. Chronic pelvic pain, one of the symptoms of the disease, badly affects the quality of life of affected women. Currently available treatments…

Key Points Lay Summary

The Impact of Painful Sex on the Physical and Mental Wellbeing of Adolescent and Young Adult Women

Clinicians should ask adolescents and young women about painful sex, not just talk about contraception and the prevention of sexually transmitted diseases. This is because painful sexual intercourse could have a negative impact on relationships and peer engagement, which is very important for the formation of identity during adolescence.  According to a study published in the Journal of Adolescent Health, painful sexual intercourse impacts adolescents and young adult women both with and without endometriosis. This has a negative effect on…

Key Points Lay Summary