Özge Özkaya, PhD

Özge has a Phd in Molecular Biology and several years experience working as a bench scientists. She has been working in science communication since 2014.

Endometriosis and Inflammation: How to Treat it?

Women with endometriosis have systemic and localized inflammation within eutopic and ectopic endometrial tissues found in a study published in the "American Journal of Reproductive Immunology". More importantly, the study also found that the inflammation caused by the disease could be reduced using hormonal therapy. This finding could change the lives of women affected by this debilitating disease causing infertility and chronic pain. It is already known that inflammation plays a key role in endometriosis. However, it is not clear…

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New Signaling Pathway Could Be Crucial in the Development of Endometriosis

RAMP1 signaling is crucial for growth and blood and lymphatic vessel formation in endometrial tissue, according to a new study published in the Journal of Cellular and Molecular Medicine. This suggests that blocking RAMP1 could be a new way to treat the disease. Using a mouse model of endometriosis, researchers in Japan demonstrated that the neuropeptide calcitonin gene-related peptide (CGRP) and its receptor, Receptor Activity-Modifying Protein 1 (RAMP 1) are crucial for the growth of endometrial tissue.  Neuropeptides are small…

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A new Marker to Detect Endometriosis and Its Severity?

Macrophage migration inhibitory factor (MIF) could be a novel marker that could help diagnose endometriosis as well as to detect its severity. This is according to a new study by researchers in Egypt, published in the scientific journal "BMC Women’s Health". There are currently no reliable markers that can detect endometriosis in a non-invasive method and laparoscopic surgery remains the gold-standard diagnostic tool. However, this is an invasive method that requires surgical incisions to be made. Macrophage migration inhibitory factor, MIF,…

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Assessment of Reproductive Health for Women With Endometriosis

Researchers in Iran developed a new and reliable patient-generated instrument to measure the reproductive health of women with endometriosis. Health providers as well as researchers can use the questionnaire to better understand the impact of the disease on women’s reproductive health over time and better meet their needs. Endometriosis affects many dimensions of reproductive health in affected women including physical, psychological, and sexual function. This is the first instrument that measures reproductive health in women with the disease. Researchers used a…

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Sexual Quality of Life in Women With Endometriosis

Painful intercourse, more severe period pain, worse health-related quality of life, and unemployment are all associated with worse sexual quality of life in women with endometriosis. This is according to a Dutch study published in the scientific journal Sexual Medicine. Being aware of these factors can help clinicians better address any issues related to the sexual quality of life.  The findings of this study also underscore the potential usefulness of the five-item sexual intercourse sub-scale of the endometriosis health profile-30…

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Effect of Endometriosis on IVF Success Rates

Endometriosis lowers the rate of cumulative live births during in vitro fertilization (IVF). However, this is due to a lower number of embryos being available for transplantation rather than their quality. This is according to a study published in the "Journal of Clinical Medicine". Cumulative live birth rate reflects the chance of getting pregnant over many IVF cycles as opposed to each cycle.  In this study, Dr. Boucret et al. sought to understand the impact of endometriosis on IVF success rates…

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New Rat Model of Endometriosis Could Help Researchers Develop New Treatments for the Condition

Researchers in Belgium developed a new rat model of endometriosis. The animals showed signs of ongoing pain meaning that the model could provide a tool for researchers to develop potential new ways to treat the different symptoms of the condition including chronic pelvic pain. Endometriosis is a deliberating condition affecting approximately one in 10 women of fertile age. Chronic pelvic pain, one of the symptoms of the disease, badly affects the quality of life of affected women. Currently available treatments…

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The Impact of Painful Sex on the Physical and Mental Wellbeing of Adolescent and Young Adult Women

Clinicians should ask adolescents and young women about painful sex, not just talk about contraception and the prevention of sexually transmitted diseases. This is because painful sexual intercourse could have a negative impact on relationships and peer engagement, which is very important for the formation of identity during adolescence.  According to a study published in the Journal of Adolescent Health, painful sexual intercourse impacts adolescents and young adult women both with and without endometriosis. This has a negative effect on…

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Is Endometriosis More Common Among Women of Certain Race/Ethnicity?

Race/ethnicity seems to have an influence on the prevalence of endometriosis with black women appearing to be less likely to be diagnosed with the disease compared to white women. However, other factors such as access and response to treatment may also influence the rate of "endometriosis" diagnosis. Understanding whether the prevalence of endometriosis really does differ between racial/ethnic groups can improve the ability of doctors to provide a timely and accurate diagnosis to all women and improve patient care. In…

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A New Treatment Approach for Endometriosis?

A new approach may be effective at relieving pain associated with endometriosis according to a study published in the PM&R Journal. The new technique may also improve “overall pelvic function, particularly in relation to intercourse, working, and sleeping,” according to the authors.  This new method involves pelvic-floor musculature trigger-point injections and peripheral nerve hydrodissection.  Trigger point injection is usually used to treat muscle pain as well as fibromyalgia and tension headaches. Small amounts of anesthetic and steroid are injected into the…

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Cabergoline or Progesterone not Effective in Rat Model of Endometriosis

Oral treatment with cabergoline or micronized progesterone for four weeks is not effective in the regression of endometriotic implants in a rat model of the disease. This is according to a study published in the "Journal of Investigative Surgery".  Cabergoline is a compound that mimics the action of the signaling molecule dopamine. It also inhibits the formation of new blood vessels, a biological event that is important for the development of endometriosis.  Micronized progesterone is progesterone that has been modified…

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Endometriosis Diagnosis in White, Black, and Asian Women

In a commentary published in the "International Journal of Obstetrics and Gynaecology", Drs. Farland and Horne talk about a study by researchers in Canada and the Philippines, which found that black women are less likely, and Asian women are more likely to be diagnosed with endometriosis compared to white women. According to Drs. Farland and Horne, there are many unanswered questions regarding this disparity in diagnosis. For example, it is not clear whether these associations are the result of diagnostic bias or…

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How Can Racial and Ethnic Disparities Be Reduced Among Women’s Health and Healthcare?

The American College of Obstetricians and Gynecologists published a set of recommendations to help reduce racial and ethnic disparities in women’s health and healthcare and encourage obstetricians, gynecologists, and other health care practitioners to engage in activities to help achieve this goal. Significant racial and ethnic disparities still exist in women’s health and healthcare in the U.S.  According to the committee opinion published in the medical journal Obstetrics & Gynecology, in 2015, obstetricians and gynecologists must be aware of such…

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Risk Factors Associated with Ureteral Endometriosis

Patients with severe endometriosis, uterosacral ligament deep involvement with endometriosis lesions of  3 cm in diameter or more, and the presence of previous endometriosis surgery have a significantly higher risk of having ureteral endometriosis. This is according to a study published in the Archives of Gynecology and Obstetrics. The authors of the study also suggest that laparoscopic ureterolysis and ureteroneocystostomy are both safe and have a low complication rate with low endometriosis recurrences. These findings are important because they allow…

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New Insights on Infertility and Low Success Rates of Assisted Reproduction in Women with Endometriosis

The fluid surrounding immature eggs waiting to mature and be fertilized by a sperm to lead to pregnancy is different in women with endometriosis compared to those without, according to a study published in Molecular Biology Reports. This could explain, at least in part, the low success rate of assisted reproductive techniques for couples in which the woman has endometriosis.  The difference is at the level of cytokines, which are signaling molecules that different cells of the immune system use…

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Hysterolaparoscopy Plus Assisted Reproduction Improves Fertility in Women with Endometriosis

Hysteroscopy and laparoscopic surgery is an effective and reliable therapeutic procedure, confirmed a study published in the "Journal of Clinical Medicine". The approach is even more effective when combined with assisted reproductive techniques such as artificial insemination and in vitro fertilization (IVF) performed in a timely manner following surgery.  The combination of the two approaches significantly improves women’s reproductive performance, and enhances their wellbeing and quality of life, the study found. For the study, a team of researchers in Hungary…

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A Routine Pelvic Ultrasound Examination Should Include an Evaluation for Endometriosis

Routine pelvic ultrasound examination should be extended beyond the uterus and ovaries into the posterior and anterior pelvic compartments, according to Australian doctors.  With such examinations, deep infiltrating endometriosis nodules can be searched, say the authors, allowing women to be diagnosed before surgery. This way, a well-prepared team of surgeons can perform a single operation to treat patients. In order to show how the evaluation for endometriosis can be included in a routine pelvic ultrasound examination, Drs. Sophie Piessens and…

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Can Controlled Trials Help Surgeons Decide on Best Way to Treat Endometriosis-Associated Pain?

It may not be realistic to base the decision on the best way to surgically treat pain in a woman with endometriosis on the results of surgical randomized controlled trials. This is according to a study by researchers at the Royal Hospital for Women, and the School of Women's and Children's Health at the University of New South Wales in Sydney, Australia. However, surgeons must be willing to “accept and adopt the evidence when it does demonstrate a particular outcome,"…

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Does Getting Pregnant Really Help When You Have Endometriosis?

Pregnancy has a favorable impact on the volume of deep infiltrating endometriosis lesions according to a study published in the scientific journal "PLoS One". This is the first study that demonstrates such a favorable impact of pregnancy on endometriosis lesion volume. For the study, researchers led by the French researcher Dr. Charles Chapron compared the volume of deep infiltrating endometriosis lesions before and after pregnancy. They did this using magnetic resonance imaging (MRI), an imaging technique that uses a magnetic…

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Endometriosis May Change Women’s Personality, Study Suggests

The personality of women may be altered as a result of endometriosis, according to a study published in the Journal of "Psychosomatic Obstetrics & Gynecology". This finding suggests that a better understanding of the disease is needed in order to provide affected women the best possible care by a multi-disciplinary team that includes psychologists. Endometriosis is a disease that is multidimensional. It has a wide range of symptoms, including chronic pain. In addition, its likely course is full of uncertainties…

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