Özge Özkaya, PhD

Özge has a Phd in Molecular Biology and several years experience working as a bench scientists. She has been working in science communication since 2014.

Potential new Target to Reduce Endometriosis Pain

The inflammatory mediators, bradykinin, and bradykinin B1 receptor may play a role in the onset of endometriosis-associated pain according to a new study by Chinese researchers. They do so by inducing the prostaglandin signaling pathway. Therefore, targeting these biological pathways could be a new therapeutic approach for endometriosis and increase patients’ quality of life. Although pain is one of the main symptoms of endometriosis researchers do not fully understand its exact cause and mechanism in the disease. However, they know…

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Research Identifies New Genes That Could Be Targeted to Treat Endometriosis

Researchers identified three new genes that could help understand the invasiveness of endometriosis. They also identified one new gene that could be related to the recurrence of the disease. These genes may potentially be new therapeutic targets for endometriosis. In order to find new biomarkers and therapies for endometriosis, two researchers from the University of Science and Technology in Wuhan, China, researchers analyzed the common characteristics of endometriosis and endometriosis-related type ovarian cancer by screening differentially expressed genes between the…

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Impact of Endometriosis on Work Life in Finnish Women

Endometriosis is associated with poor "work ability" at late fertile age, according to a Finnish study published in the journal Acta Obstetricia et Gynecologica Scandinavica. Although women with endometriosis have more disability days, their employment rate and risk of early retirement are similar to those without the disease at late fertile age, the study found. Based on these findings, the authors encourage healthcare practitioners to recognize the relevance of organizing timely care for endometriosis patients to promote their "work ability". …

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Ovarian Cancer Survival in the presence of Endometriosis

Women with ovarian cancer and histologically proven endometriosis have longer overall survival compared to those with ovarian cancer but no endometriosis, found a study published in the American Journal of Obstetrics & Gynecology.  “[…] Women diagnosed as having ovarian cancer and concurrent endometriosis should be explained the role of endometriosis in ovarian cancer survival,” the authors of the study wrote. They added that future studies on the treatment and prognosis of ovarian cancer should consider stratifying patients by endometriosis status…

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Depression and Anxiety Common in Women with Endo

Symptoms of depression and anxiety are frequent among women with endometriosis and are related to chronic pain, confirms a review of the literature and meta-analysis published in the Journal of Women's Health.  According to the study authors, correlating factors should be investigated further. Researchers have suggested that the symptoms of endometriosis such as chronic pelvic pain are associated with psychological distress in women with the disease. In order to explore the strength of the associations between endometriosis and depression or…

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Chemical Found in Self-Care Products May Be Linked to Endometriosis

There may be a link between exposure to phthalates and endometriosis according to a new study published in the Journal of Assisted Reproduction and Genetics. Although more research is needed, these findings could be translated into clinical practice according to Dr. Alessandro Conforti and the co-authors of the study. Phthalates often called "plasticizers" are a group of chemicals used to make plastics more durable. They are widely used in many products including vinyl flooring, lubricating oils, and personal-care products such…

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Technical Facts for the Prevention of Complications After Deep Endometriosis Surgery

There are no differences in the risk of rectovaginal fistula in women with rectovaginal endometriosis who were managed by a liberal or restrictive policy of preventive stoma according to a study by French researchers published in the Journal of Minimally Invasive Gynecology. According to the authors, this result suggests that stomas should not be routinely performed in women with rectal and vaginal sutures. Instead, they should be carefully evaluated based on risk factors such as distance from the anal verge.…

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Strong Geographical Gradient in Endometriosis Incidence Identified

The geographical distribution of new endometriosis cases showed a very strong north-south spatial gradient in the highly industrialized Friuli Venezia Giulia region of Italy, according to a new study published in the International Journal of Environmental Research and Public Health. “The cluster of 5 municipalities in the industrialized and polluted south-east part of the region is suggestive,” the researchers wrote. But they said information about patients' characteristics and exposure histories are limited due to the ecologic nature of the study. The incidence estimates…

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Endometriosis and Rheumatoid Arthritis, Could There Be a Link?

Patients with endometriosis have a higher risk of rheumatoid arthritis according to a study published in the journal Rheumatology. This finding suggests that rheumatologists should be especially mindful of the possibility of underlying endometriosis when treating women with rheumatoid arthritis. The molecular mechanism of how rheumatoid arthritis and endometriosis may be linked remains unknown. But what is known is that both diseases are inflammatory in nature. It is also thought that autoimmunity, like in the case of rheumatoid arthritis, may…

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Medical Examination Reduces Anxiety in Women With Suspected Endometriosis

Anxiety levels go down after medical examination in women with suspected endometriosis, found a study by Italian researchers that was published in the Journal of Psychosomatic Research. This was especially pronounced in women who had higher baseline distress and who sought information online. “To create a trustful relationship with women, providing them with tailored counseling, seems essential to improve their psychological wellbeing,” wrote Alessandro Arena and the co-authors of the study.  Their aim was to evaluate the impact of the…

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The Severity of Pain Does not Predict Endometriosis or its Stage, Study Confirms

The intensity of pain a woman experiences could predict whether or not she would undergo laparoscopic surgery. However, it could not predict whether she has endometriosis or in case she did, the severity of her disease. This is according to a study published in "The Australian and New Zealand Journal of Obstetrics and Gynaecology". “These findings indicate the need to review current frameworks guiding practice toward surgery for pelvic pain”, wrote Isabelle Conroy and the co-authors of the study. The…

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How Does Endometriosis Affect Patients Quality of Life?

Health-related quality of life is significantly lower in patients with endometriomas or deep infiltrating endometriosis compared to women without the disease. This is according to the results of a recent study in adult Spanish women that was published in the "International Journal of Environmental Research and Public Health".  This is an important finding because it may have important implications in terms of prevention, clinical practice, and intervention. In order to assess health-related quality of life in adult Spanish women with endometriomas…

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Adhesion Barrier Helps After Endometriosis Surgery

An adhesion barrier, named "4DryField® PH" significantly reduced the formation of adhesions following endometriosis surgery, according to a new study by German scientists.  The formation of adhesions following endometriosis surgery is a severe problem that affects 90% of patients. The findings of this study, therefore, provide practical benefits for endometriosis patients undergoing surgery.  In order to evaluate the effectiveness of this particular adhesion barrier in preventing the formation of adhesions following endometriosis surgery, a team of researchers led by Dr.…

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The Surgical Management of Endometriosis of the Ureter and Bladder

Laparoscopic surgery is feasible and safe to manage endometriosis of the ureter and bladder, according to a new study published in the Journal of Minimally Invasive Gynecology. According to the authors of the study, ureteral resection is more strongly associated with laparotomy and more complications compared to other procedures and should be reserved for cases where ureterolysis is not feasible or in case of recurrence. The best surgical management of patients with endometriosis of the ureter and bladder remains controversial. …

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Peritoneal Pockets and Endometriosis

Infertile women with peritoneal pockets had more endometriosis compared to women without pockets according to a study published in the Journal of Obstetrics and Gynaecology Canada. Severe pelvic pain was also associated with the presence of pockets and the presence of endometriosis as well as its severity. These findings are important because they can guide decision-making about whether or not to treat peritoneal pockets in women with infertility and endometriosis. In order to evaluate the prevalence of endometriosis and peritoneal…

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Low-Dose Aspirin as a Potential Treatment for Endometriosis-Related Infertility

Treatment with low-dose aspirin could downregulate progesterone resistance and increase the expression of leukemia inhibitory factor (LIF) during the implantation window, according to a study that used a rat model of endometriosis. This, in turn, could improve endometrial receptivity and increase the pregnancy rate.  These findings are important because they suggest that this approach could also be used to treat infertility in women with endometriosis. It is thought that 30 to 50% of women with endometriosis are infertile or have…

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Genetic Predisposition to Endometriosis

Certain genetic polymorphisms, called SNPs, in the ESR2 and CYP19A1 genes, were more prevalent among patients with endometriosis compared to women without the disease according to a study by researchers in Poland.  A better understanding of the genetic mechanisms underlying the disease, could pave the way to the development of new therapies in the future and improve outcomes in endometriosis.  Previous research has shown that two genes, estrogen receptor 2 (ESR2) and cytochrome P450 family 19 subfamily A member 1 (CYP19A1)…

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Endometriosis Surgery Improves Sex Life

Women who underwent laparoscopic resection surgery to treat their deep infiltrating endometriosis had improved sexual quality of life and health-related quality of life according to a new study published in the Journal of Minimally Invasive Gynecology. These findings are important because they can help guide the right standard of care in the surgical treatment of deep infiltrating endometriosis. In order to investigate the long-term effects of laparoscopic excision surgery to treat deep infiltrating endometriosis on the sexual quality of life and…

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Could There Be a Relationship Between Endometriosis and the "Restless Leg Syndrome"?

Women with endometriosis have a significantly higher prevalence of restless leg syndrome according to a study published in the scientific journal "Frontiers in Endocrinology". This is the first study highlighting such an association between the two conditions. These findings are important because they can pave the way to the discovery of new therapies that could address both conditions and improve patients’ quality of life. Restless legs syndrome is characterized by an uncontrollable urge to move the legs especially in the evening…

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Surgery for the Treatment of Endometriosis of the Diaphragm and Thorax

Diaphragmatic and thoracic endometriosis starts in the abdominal wall of the diaphragm and later invades the thorax, based on findings from a series of patients surgically treated for the disease, reports a study published in the Journal of Gynecology Obstetrics and Human Reproduction.  Therefore, early diagnosis is of great importance, according to Dr. Alexia Wetzel and the co-others of the study who stress that chest pain should be systematically investigated in patients experiencing pelvic endometriosis. To review the current management…

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