Selma Oransay, MD

Dr. ORANSAY is 35 years experienced clinician in OB/ GYN. She worked in the main national maternity educational hospital of Turkey for 20 years than she moved to İstanbul and worked in private hospitals. Her published articles are mostly on topics of menopause and infertility. She is also experienced as a voluntary OB/GYN doctor in African healthcare program.

Best endometriosis articles of the past year.

Dr.Stowall, from the Department of Obstetrics and Gynecology of Methodist Hospital, Dallas, Texas, USA penned this letter and recently published it in the Journal of Obstetrics and Gynecology to show his remarks of importance on four best publications of the last year. The first summary was evaluating the paper by Taylor et al. published in NEJM, concerning two multicenter, placebo-controlled, randomized, double-blind trials; both randomized more than 800 patients to assess the effects of 150- and a 400-mg/day doses of…

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Maternal and fetal outcomes in women with endometriosis : A review and meta-analysis

Lalani et al from Dept. of Obstet. and Gynecol. , University of Ottowa, Canada, recently published this systemic review and meta-analysis of observational studies in the Journal of Human Reproduction, aimed to present the difference in the maternal and fetal outcomes during pregnancies with or without endometriosis. Endometriosis is a disease to alter the ovulation, oocyst production, peritoneal fluid inflammatory cells content and endometrial tissue that could affect the peri-implantation period of conceiving and normal embryonic development. Even the pregnancy…

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PROPOFOL: a new combat for endometriosis?

Feng et al, from the Department of  Gynecology Weifang Medical University Hospital, Shandong, China, recently published their prospective experimental research in the journal Experimental and Therapeutic Medicine. Propofol, a rapid and short-term anesthetic substance, recently has been shown to prevent cancer through inhibiting tumor cell proliferation directly or indirectly, by facilitating apoptosis. The researchers postulate that Propofol can have similar effects on endometriosis cells due to their behavior similar to tumor cells. To evaluate the probable role of Propofol on inhibiting the endometriotic cell proliferation and…

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Laparoscopic surgery of endometriosis through three compartments

This case study which is published in the J. of Minimally İnvasive Gynecology is the video demonstration of Collin et al who performed the laparoscopic operation of their patient in Gynecologic Surgery Department of Strasburg Hospital University, France. 37 years old nulliparous patient who has dysmenorrhea, dyspareunia, pollakiuria, dyschezia, and macroscopic menstrual hematuria, underwent MRI examination. An endometriotic nodule found in bladder including involving the anterior wall of the womb. There was also infiltration of uterine ligaments, ovaries and bowel wall,…

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MTA1 as a predictor for the progression of endometriosis.

Jing Zhang et al. from the Department of Obstetrics and Gynecology, Affiliated Haikou Hospital, Xiangya Medical College of Central South University, Hainan, China, published their article in the open access medical journal "Medicine". Their aim was to evaluate the relationship between endometriosis and tumor metastasis gene MTA1 to search its role on the progression and the recurrence of endometriosis. The surgical and medical treatment combination for endometriosis improve the therapeutic effect in a short time period but recurrence cannot be avoided. Endometriosis is a…

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Cosmetics and some household products could be responsible for worsening endometriosis.

A controlled clinical study recently published in the Journal of Human Reproductive Sciences,  composed by Nazir et al. from the University of Health Sciences, Lahore, Pakistan. The study compared the blood diethyl hexyl phthalate (DEHP) levels of fifty infertile women laparoscopically diagnosed withendometriosis to those of age-matched fifty healthy fertile women. Statistically significant high level of DEHP was found out in women with endometriosis, while no detectable levels present in the control group. The increased level of serum DEHP results supported the results…

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Reduced pain and increased fertiliy rates after surgery for colorectal endometriosis

This prospective cohort study which recently published in AOGS by Hudelist et al. from Oslo University, Norway is about their one hundred thirty-four laparoscopic operations of DIE cases performed between 2011 and  2016, in a tertiary center in Oslo. The cases with the diagnosis of severe DIE before surgery complained some degrees of pelvic pain and infertility, were referred to this tertiary hospital in Oslo. Authors performed two types of laparoscopic surgery techniques namely segmental bowel resection (SR) and full…

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How to evaluate ureteral endometriosis : A review of the literature

In this recently published review of the literature, Barra et al. from Genova, Italy intend to provide a useful tool to guide physicians in the management of deep infiltrating endometriosis. Authors elected 67 abstracts from Pubmed and Medline in accordance with PRISMA statement have been reviewed to access the epidemiology, pathogenesis, diagnosis, treatment and malignant transformation risk of ureteral endometriosis. The tables prepared by the authors to give important messages to the physicians, gynecologists and radiologists are: 1) Deeply infiltrated endometriosis, including…

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Endometriosis as a chronic disease: The benefits for the patients

Rebecca O'Hara et al. from Monash University, Melbourne, Australia, recently published their qualitative case study in the Journal "Australian Health Review", to build a National Policy about endometriosis considering as a chronic disease.    In Australia, long-term complex diseases are managed within a chronic disease framework. If endometriosis could be included in the existing chronic disease management plans (CDMPs), a better recognition of the disease will emerge, will result in the better promotion of individualized care and multidisciplinary management, as other chronic…

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The vaginal delivery rate of singleton term pregnancies still remains the same after total deep infiltrating endometrosis excisions

This recently published report in the Journal of Fertility Sterility is planned as a  matched case-control study, by Nirgianakanis et al. from the University of Bern, Switzerland. Authors claimed their study is the first because previous studies on pregnancy outcome after laparoscopic surgery of deeply infiltrated endometriosis (DIE) have some failures.  Pregnancy outcomes and delivery risks are compared to the women without endometriosis, and the type of bowel surgery, endometriosis stage, level of bowel anastomosis when performed, partial resection of the posterior vaginal fornix,…

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Is there a new hope for the prevention of endometriotic invasions?

This research which recently published in Biomed Research International is performed by Xiaomei et al. from Obst/Gyn, Pathology and Genetic departments of three hospitals in Changsha, CHINA. The authors planned a prospective and controlled biochemical study to specify the role of autophagy in endometriosis. Although the role of autophagy is well-known in the development of various disorders, its mechanism in different diseases is not the same,  and its role in endometriosis has not been elucidated yet.  To investigate the effect…

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How to improve the current ASRM classification of endometriosis?

In this article which recently published in Best Practice&Research Clinical Obst&Gyn.  from the University of Sao Paulo, Brazil, Andres et al.  penned a review of the classification of endometriosis in chronological order, and discussed the limitations of existing classification systems to indicate a new and better one. An ideal endometriosis classification system should be reachable, reproducible, easy to perform, should provide the information about the severity and type of endometriosis, and further, the severity and type of symptom including pain and…

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Can we predict the complexity of laparoscopic surgery by ultrasound?

This is a multicentric, retrospective cohort study recently published in the Journal of Minimally Invasive Gynecology by Tompsett et al. in which the results of the transvaginal ultrasonographic examinations (TVS) are compared to the results of the laparoscopic operations performed in the Department of OB/GYN Wollongong Hospital, New South West, Australia.   Hundred and fifty-five women in their reproductive ages, who have chronic pelvic pain at least six months or a history of endometriosis, underwent TVS examination at Nepean Hospital, and a private…

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Endometriosis Development: Pathogenesis and genomics

In this review recently published in the International Journal of Molecular Sciences, Baranow et al from Saint Petersburg, Russia,  hypothesize the existence of an endometriosis development genetic program (EMDP) that governs the origin of endometrium stem cells programmed for endometriosis; their transition (metaplasia) into mesenchymal SCs; and their invasion of the peritoneum and progression to endometriotic lesions. Discussing the role of SCs they work on these three sensitive periods (SP). SP1 is the initial stage of female reproductive tract development that corresponds to 8-10…

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