Selma Oransay, MD

Dr. ORANSAY is 35 years experienced clinician in OB/ GYN. She worked in the main national maternity educational hospital of Turkey for 20 years than she moved to İstanbul and worked in private hospitals. Her published articles are mostly on topics of menopause and infertility. She is also experienced as a voluntary OB/GYN doctor in African healthcare program.

Estrogen Receptor Signaling and Endometriosis-Associated Ovarian Cancer

Andersen et al. published a prospective cohort study in the Journal of Hormones and Cancer to enlighten the estrogen signaling pathway during the transition from endometriosis to endometriosis-associated ovarian cancer. Given the shared pathway of endometriosis and ovarian cancer as estrogen-responsive disease entities, estrogen signaling has been implicated in endometriosis-associated ovarian cancer. To examine the relation and the progression, and to be able to observe its association with estrogen signaling, eighty-three samples collected from the patients with endometriosis, including 11 atypical endometriosis, 9…

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A link between endometrioid ovarian carcinoma and endometriosis.

Ciavattini et al.from Polytechnic University Ancona, Italy create a pilot study which recently published in Oncology Letters to clarify the link between endometriosis and endometrioid ovarian cancer. The unfolded protein response (UPR) activity as a promoter of neoplastic progression of malignancies is well known. In hypoxic conditions, normally pro-apoptotic signals, cellular metabolic changes, and stimulation of neoangiogenesis occur within the cell, if it could not be restored, terminally ends with apoptosis-mediated cellular death. In a malignant cell, UPR activation via Endoplasmic Reticulum (ER) transmembrane receptors such…

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Building an ultrasonographic database for superficial endometriosis.

Chowdary et al. from University of Auckland, Australia, recently published a retrospective, small group study in Australian New Zeland Journal of Obstetrics and Gynecology, to demonstrate ultrasonographic findings of mild endometriosis patients with pelvic pain are associated with their laparoscopic diagnosis. The study was performed on fifty-three patients with pelvic pain and diagnosed as superficial endometriosis after the ultrasonography performed by a single expert sonologist between 2012 and 2015.  The laparoscopic findings of seventy-nine percent of the patients were consistent when compared…

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Can we prevent the progression of endometriosis?

Torres-Reveron et al. from the University of Texas, USA, planned this prospective laboratory research on female rats to assay the reduce on the progression of endometriosis and recently published the results in PloS One. At first,  endometriosis was induced in female rats surgically, while one half have undergone a sham operation.  The authors did not find any significant effect of surgeries on cyclicity or on the behavioral parameters. After seven days of surgery for generating endometriosis, CHRH1 levels were elevated twice in endometriosis,…

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Somatic mutations in iatrogenic endometriosis.

Lac and al., from the Department of Molecular Oncology in BC Cancer Research Center, Vancouver, Canada, planned a retrospective and multinational research to investigate the prevalence of somatic cancer-driver mutations in incisional endometriosis and recently published in the "Journal of Human Reproduction". Their aim was to investigate if incisional endometriosis harbor somatic cancer-driver mutations like deeply infiltrated endometriosis (DIE), as was previously reported. Endometriosis specimens of 40 women with incisional endometriosis and 36 women with DIE without a known history of malignancy were collected from clinics of Canada,…

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Is the mystery for progression of endometriosis hiding out in abnormally located endometrial cells?

This prospective study was conducted by Hapangama et al. in Research İnstute of the University of Liverpool, UK, and the results have recently published in the Journal of Human Reproduction. The authors hypothesized that abnormally located endometrial basalis-like (SSEA1/nSOX9+)cells could be contributing to ectopic endometriotic lesion formation, based on the previous findings of a higher number of  "basalis-like cells"  in eutopic endometrium of women with endometriosis, these cells have a [SSE1(+)/SOX9(+)] signature showed progenitor activity in-vitro, are also present in the ectopic endometrium. All these findings support…

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What clinicians know about adenomyosis? Any association with severe endometriosis?

Dior et al. from the Royal Women's Hospital in Parkville, Australia, designed a prospective study to assess the association between severity of endometriosis and sonographic evidence of adenomyosis (SEOA) in their recently published article appearing in The Journal of Minimally Invasive Gynecology. Their research also informs about the gene expression in eutopic endometrium to tell the difference in patients with or without adenomyosis. The research included 234 women, with an average age of 30.6 years with pelvic pain symptoms, directed to a…

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Is bowel preparation really necessary before rectal water contrast-transvaginal ultrasonography?

Ferrero et al., from Unit of Obstetrics-Gynecology in IRCCS Ospedale Policlinico San Martino, Genoa, Italy, recently published a prospective study in the Journal of Ultrasound Medicine. The first aim of the authors was to compare the performance of "Rectal Water Contrast Transvaginal Ultrasonography" with or without bowel preparation (BP). The second objective was to compare the estimated length of major nodules, mucosal infiltration levels, the distance of nodules from the anal verge, and the presence of multifocal disease inventions of two…

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Drugs targeting estrogen biosynthesis opening up new approaches to the treatment of endometriosis.

Gibson et al., from the Univerity of Edinburgh, UK, take over a new interest about endometriosis occurrence and progress by endometrial tissue intracrinology in their recently online published article in International Journal of Molecular Sciences. The authors summarize the last decade improvements about intracrinology and the role in endometriosis as well as endometrium cancer dividing into sections. The ability of cells within non-gonadal tissues to both produce a hormone and to respond to that same product can be defined as "intracrine".  Recent…

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The pain and its severity in deeply infiltrating endometriosis patients

Liang et al. from the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Sun Yat-sen University, China, recently published an interesting paper in the Journal of Pain Research, a prospective study to reveal the relationship between neurogenesis and other potential factors for pain and its severity in deeply infiltrating endometriosis.  Sixty-four deeply infiltrating endometriosis patients were involved in this study, which the endometriotic nodules of them were resected from uterosacral ligaments and/or rectovaginal septum laparoscopically. Before the evaluation, patients were divided…

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The diagnosis and management of endometriosis in Korea

The Korean Society of Endometriosis has scrutinized the present published literature of endometriosis in the domestic and international platform to provide new guidelines and the clinical management of the disease. The study was recently published in the journal "Obstetrics and Gynecology Science". While analyzing the data on diagnosis and treatment of endometriosis, they categorized their recommendations depending on four grades scale as Meta-analysis or multiple randomized trials, large non-randomized trials or case-control/cohort studies, non-analytic studies or case reports/series and expert clinicians experiences.  Although the…

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Best endometriosis articles of the past year.

Dr.Stowall, from the Department of Obstetrics and Gynecology of Methodist Hospital, Dallas, Texas, USA penned this letter and recently published it in the Journal of Obstetrics and Gynecology to show his remarks of importance on four best publications of the last year. The first summary was evaluating the paper by Taylor et al. published in NEJM, concerning two multicenter, placebo-controlled, randomized, double-blind trials; both randomized more than 800 patients to assess the effects of 150- and a 400-mg/day doses of…

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Maternal and fetal outcomes in women with endometriosis : A review and meta-analysis

Lalani et al from Dept. of Obstet. and Gynecol. , University of Ottowa, Canada, recently published this systemic review and meta-analysis of observational studies in the Journal of Human Reproduction, aimed to present the difference in the maternal and fetal outcomes during pregnancies with or without endometriosis. Endometriosis is a disease to alter the ovulation, oocyst production, peritoneal fluid inflammatory cells content and endometrial tissue that could affect the peri-implantation period of conceiving and normal embryonic development. Even the pregnancy…

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PROPOFOL: a new combat for endometriosis?

Feng et al, from the Department of  Gynecology Weifang Medical University Hospital, Shandong, China, recently published their prospective experimental research in the journal Experimental and Therapeutic Medicine. Propofol, a rapid and short-term anesthetic substance, recently has been shown to prevent cancer through inhibiting tumor cell proliferation directly or indirectly, by facilitating apoptosis. The researchers postulate that Propofol can have similar effects on endometriosis cells due to their behavior similar to tumor cells. To evaluate the probable role of Propofol on inhibiting the endometriotic cell proliferation and…

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Laparoscopic surgery of endometriosis through three compartments

This case study which is published in the J. of Minimally İnvasive Gynecology is the video demonstration of Collin et al who performed the laparoscopic operation of their patient in Gynecologic Surgery Department of Strasburg Hospital University, France. 37 years old nulliparous patient who has dysmenorrhea, dyspareunia, pollakiuria, dyschezia, and macroscopic menstrual hematuria, underwent MRI examination. An endometriotic nodule found in bladder including involving the anterior wall of the womb. There was also infiltration of uterine ligaments, ovaries and bowel wall,…

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MTA1 as a predictor for the progression of endometriosis.

Jing Zhang et al. from the Department of Obstetrics and Gynecology, Affiliated Haikou Hospital, Xiangya Medical College of Central South University, Hainan, China, published their article in the open access medical journal "Medicine". Their aim was to evaluate the relationship between endometriosis and tumor metastasis gene MTA1 to search its role on the progression and the recurrence of endometriosis. The surgical and medical treatment combination for endometriosis improve the therapeutic effect in a short time period but recurrence cannot be avoided. Endometriosis is a…

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Cosmetics and some household products could be responsible for worsening endometriosis.

A controlled clinical study recently published in the Journal of Human Reproductive Sciences,  composed by Nazir et al. from the University of Health Sciences, Lahore, Pakistan. The study compared the blood diethyl hexyl phthalate (DEHP) levels of fifty infertile women laparoscopically diagnosed withendometriosis to those of age-matched fifty healthy fertile women. Statistically significant high level of DEHP was found out in women with endometriosis, while no detectable levels present in the control group. The increased level of serum DEHP results supported the results…

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Reduced pain and increased fertiliy rates after surgery for colorectal endometriosis

This prospective cohort study which recently published in AOGS by Hudelist et al. from Oslo University, Norway is about their one hundred thirty-four laparoscopic operations of DIE cases performed between 2011 and  2016, in a tertiary center in Oslo. The cases with the diagnosis of severe DIE before surgery complained some degrees of pelvic pain and infertility, were referred to this tertiary hospital in Oslo. Authors performed two types of laparoscopic surgery techniques namely segmental bowel resection (SR) and full…

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How to evaluate ureteral endometriosis : A review of the literature

In this recently published review of the literature, Barra et al. from Genova, Italy intend to provide a useful tool to guide physicians in the management of deep infiltrating endometriosis. Authors elected 67 abstracts from Pubmed and Medline in accordance with PRISMA statement have been reviewed to access the epidemiology, pathogenesis, diagnosis, treatment and malignant transformation risk of ureteral endometriosis. The tables prepared by the authors to give important messages to the physicians, gynecologists and radiologists are: 1) Deeply infiltrated endometriosis, including…

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Endometriosis as a chronic disease: The benefits for the patients

Rebecca O'Hara et al. from Monash University, Melbourne, Australia, recently published their qualitative case study in the Journal "Australian Health Review", to build a National Policy about endometriosis considering as a chronic disease.    In Australia, long-term complex diseases are managed within a chronic disease framework. If endometriosis could be included in the existing chronic disease management plans (CDMPs), a better recognition of the disease will emerge, will result in the better promotion of individualized care and multidisciplinary management, as other chronic…

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