Hale Goksever Celik, MD

Dr. Goksever Celik is an obstetrician and gynecologist, graduated from the medical school of the Hacettepe University in Ankara, and trained through Obstetrics and Gynecology fellowship at Dokuz Eylul University in Izmir. She has been a postdoctoral research fellow at Molecular Biology and Genetics at Istanbul University. She has been participating in several research especially interested in the association between endometriosis surgery and ovarian reserve and the genetic basis of endometriosis.

Early maternal separation and endometriosis progression in adult mice

The quality of life in the women affected by endometriosis depends on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Although several studies have been performed to investigate the underlying pathophysiologic mechanism, it is still poorly understood. Early-life adversity including abuse, neglect, loss of a parent, and traumatic events has been found to be associated with the development and progression of endometriosis. Preterm birth, formula feeding, intrauterine exposure to diethylstilbesterol, and childhood physical…

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The impact of obesity on safety and feasibility of laparoscopic endometriosis surgery

The quality of life in the women affected by endometriosis depends on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. The most common locations of endometriosis are ovary, ovarian fossa, uterosacral ligament, and posterior cul-de-sac. Although some endometriosis-associated symptoms may be managed using medical treatments, surgical management remains the golden standard of diagnosis and the treatment algorithm.  The laparoscopic surgical route is accepted as the best approach by technological developments and improved surgical…

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Adolescent dysmenorrhea diagnosis and management

Endometriosis is usually diagnosed in reproductive-aged women. However, recent literature proved that clinical symptoms of endometriosis are also seen the adolescent girls and young women. Dysmenorrhea, the most common gynecologic complaint among this age group, can develop due to endometriosis. It is important to differentiate primary dysmenorrhea and secondary dysmenorrhea in this period. Dr.Hewitt from Ohio published a review entitled “Dysmenorrhea and Endometriosis: Diagnosis and Management in Adolescents” in the journal "Clinical Obstetrics and Gynecology". The author aimed to evaluate…

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The effect of endometriosis on the quality of life

Endometriosis, the disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity, can be diagnosed in the reproductive-aged women with an incidence of 7-15%. However, endometriosis is observed in women with chronic pelvic pain syndrome and in infertile women much more frequently. The main clinical finding of endometriosis is severe pain located in the lower abdomen during menstruation, sexual intercourse, urination, defecation, and gynecological examination. The daily routine of these women such as going to…

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Endometriosis by Race

Endometriosis is usually diagnosed in reproductive-aged women with an incidence of approximately 10%. The most common presenting symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility in patients with endometriosis. Some risk factors have been identified for the development of endometriosis. Unopposed estrogen exposure, early menarche, short menstrual cycles, long duration of menstrual flow, delayed childbearing, family history of endometriosis, and the white race are suggested to be associated with a higher risk of developing endometriosis. The basis of the…

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The predictors for sexual dysfunction in infertile women with endometriosis

Endometriosis is a disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. Its incidence ranges up to 10% of reproductive-aged women. The most common symptoms in these women are chronic pelvic pain, dyspareunia, and infertility.  Endometriosis patients also suffer from psychological distress, anxiety, and depression. All of these symptoms impair the quality of life and sexual function of these patients. Youseflu et al., from Iran, published a cross-sectional study titled “Influential factors on sexual…

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Postmenopausal endometriosis: Is it a rare phenomenon?

Endometriosis, the estrogen-dependent disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity, is generally diagnosed in the reproductive-aged women. However, recent literature proved that this disease can also be observed in the premenopausal and postmenopausal periods. Secosan et al, scientists from Romania and France, published a review titled “Endometriosis in Menopause—Renewed Attention on a Controversial Disease” in the journal named "Diagnostics". The authors aimed to evaluate postmenopausal endometriosis in all aspects, including the prevalence,…

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Maternal body mass index and neonatal outcomes in women with endometriosis

Endometriosis is defined as the localization of endometrial glandular and stromal-like tissue outside the uterine cavity. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of 25-40%.  Infertility in women with endometriosis is managed most commonly by assisted reproductive technology (ART) modalities. The recent literature provides controversial data about the obstetric outcomes of in vitro fertilization treatments in patients with endometriosis. The increased risk of preterm…

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Recurrence following surgery for subtypes of endometriosis

Endometriosis is a disease identified by the location of endometrial stromal and glandular cells outside the uterine cavity. It is considered as a gynecological disease of reproductive-aged women. Three subtypes of endometriosis are peritoneal endometriosis which defines the endometriotic lesions located on the peritoneal surface, ovarian endometrioma which are the cysts with chocolate-like content located in the ovaries, and deep infiltrating endometriosis which defines the endometriotic lesions situated more than 5 mm deep to the peritoneum. There are several treatment…

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Fertility preservation protocols in women with endometriosis

Infertility is one of the major symptoms in women with endometriosis. Childbearing at a delayed age is preferred by the majority of women recently who consult for the demand for fertility preservation procedures. There are several techniques for fertility preservation such as ovarian cortex cryopreservation, freezing of embryos and oocyte cryopreservation that has been accepted as the best option due to lower negative impact on ovarian reserve and lower associated morbidity. Although there are many publications about the outcomes of fertility…

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The predictive factors for early spontaneous miscarriage in IVF/ICSI cycles

The most common presenting complaints of endometriosis are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Affected women demand therapy for these symptoms of endometriosis, notably fertility problems. The clinical pregnancy rate has increased up to 60% in assisted reproductive technology (ART) clinics due to the developments of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) techniques. However, unfortunate obstetric outcomes such as biochemical pregnancy, ectopic pregnancy, spontaneous miscarriage, and stillbirth may be experienced resulting in decreased live birth…

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The genetic mutations in uterine adenomyosis

Adenomyosis is defined as the localization of endometrial stromal and glandular cells in the myometrium. This disease is a reproductive-aged women disease, like endometriosis. Additionally, adenomyosis is frequently observed together with endometriosis and leiomyomas due to common histological features and molecular changes. However, these diseases show some differences according to their pathogenesis, localization of the lesions and clinical features. Underlying etiopathogenetic mechanisms of adenomyosis have not been understood clearly despite several proposed theories. As in many diseases, it is thought…

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The role of microbiota in the etiopathogenesis of endometriosis

Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. Although many advanced types of research about the etiology, differential diagnosis and treatment have been performed, it still remains an enigmatic disease. Dr. Bedaiwy, a scientist and physician from Canada, published a study titled “Endometrial macrophages, endometriosis, and microbiota: time to unravel the complexity of the relationship” in the journal named "Fertility and Sterility". The role of infectious, inflammatory and immunological changes in the etiopathogenesis of endometriosis is…

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A review of endometriosis in adolescent girls and young women

Endometriosis is an estrogen-dependent disease which is commonly diagnosed in reproductive-aged women. On the other hand, this disease can develop earlier in life due to different etiopathogenetic mechanisms. Especially adolescents who experienced neonatal uterine bleeding are under the risk for endometriosis. Gałczyński et al, a group of scientists from Poland, published a mini-review titled as “Ovarian endometrioma – a possible finding in adolescent girls and young women: a mini-review” in the journal named as Journal of Ovarian Research. They aimed…

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The association between endometriosis and ectopic pregnancy

Endometriosis is a chronic inflammatory disease with a broad spectrum of symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain and fertility problems. It has been understood in the light of scientific evidence that endometriosis is also associated with other poor obstetric outcomes including early and late pregnancy complications. Ectopic pregnancy is a complication of pregnancy in which the embryo attaches outside the uterus. Yong et al, a group of scientists from Canada, published a review titled “Endometriosis and Ectopic Pregnancy:…

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Endometriosis and ovarian reserve

Endometriosis is most frequently encountered in reproductive-aged women. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of 25-40%. Although the exact mechanism explaining the association between endometriosis and infertility has not been elucidated, distorted pelvic anatomy, impaired ovarian function, altered microenvironment, affected endometrial receptivity, and embryo quality been accepted as the most common responsible mechanisms. Infertility in women with endometriosis is managed most commonly by assisted…

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Recent advances in the diagnosis and treatment of endometriosis

Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. The most common complaints of women with endometriosis are pain and fertility problems. Although many advanced types of research about the etiology, differential diagnosis and treatment have been performed, it remains a still enigmatic disease. The most commonly accepted theory which explains the development of endometriosis is retrograde menstruation theory. Other theories are celomic metaplasia, hormonal changes, oxidative stress and inflammation, immune dysfunction, apoptosis suppression, genetic predisposition, and…

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Regret assessment in women under 35 years who underwent hysterectomy

Hysterectomy is the most common gynecological operation in women for the management of benign or malign indications. Leiomyomas, menorrhagia, endometriosis, and pain unresponsive to medical treatment can be accepted as the most common indications for hysterectomy. However, hysterectomy, as the permanent loss of child-bearing capability, has several surgical risks, intraoperative and postoperative complications. Thus, the decision of hysterectomy is very difficult, especially in women under 35 years old. Bougie et al, a group of scientists from Canada, published a study…

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Recurrent endometriosis is a real challenge both for the patients and clinicians

Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Current medical and surgical treatment options have several limitations including the side effects, costs, risk of recurrence, effects on conception capability. Recurrence is a major problem that can be encountered at various rates in different publications. It can occur due to the development of de novo lesions or to in situ growth of residual foci. Ceccaroni et al, a group of scientists from Italy,…

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The effect of endometriosis on implantation in women with endometriosis associated infertility

One of the most common clinical findings of women with endometriosis is fertility problems. Women with endometriosis often benefit from in vitro fertilization methods to get pregnant. However, whether there is a detrimental effect of endometriosis on in vitro fertilization outcomes is a controversial issue. Yevseyevich et al, a group of scientists from the Russian Federation, at the RUDN University, center of reproduction and genetics NOVA CLINIC,  published a study titled “Implantation failures in women with infertility associated endometriosis” in the journal named…

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