Hale Goksever Celik, MD

Dr. Goksever Celik is an obstetrician and gynecologist, graduated from the medical school of the Hacettepe University in Ankara, and trained through Obstetrics and Gynecology fellowship at Dokuz Eylul University in Izmir. She has been a postdoctoral research fellow at Molecular Biology and Genetics at Istanbul University. She has been participating in several research especially interested in the association between endometriosis surgery and ovarian reserve and the genetic basis of endometriosis.

The association between endometriosis and ectopic pregnancy

Endometriosis is a chronic inflammatory disease with a broad spectrum of symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain and fertility problems. It has been understood in the light of scientific evidence that endometriosis is also associated with other poor obstetric outcomes including early and late pregnancy complications. Ectopic pregnancy is a complication of pregnancy in which the embryo attaches outside the uterus. Yong et al, a group of scientists from Canada, published a review titled “Endometriosis and Ectopic Pregnancy:…

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Endometriosis and ovarian reserve

Endometriosis is most frequently encountered in reproductive-aged women. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of 25-40%. Although the exact mechanism explaining the association between endometriosis and infertility has not been elucidated, distorted pelvic anatomy, impaired ovarian function, altered microenvironment, affected endometrial receptivity, and embryo quality been accepted as the most common responsible mechanisms. Infertility in women with endometriosis is managed most commonly by assisted…

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Recent advances in the diagnosis and treatment of endometriosis

Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. The most common complaints of women with endometriosis are pain and fertility problems. Although many advanced types of research about the etiology, differential diagnosis and treatment have been performed, it remains a still enigmatic disease. The most commonly accepted theory which explains the development of endometriosis is retrograde menstruation theory. Other theories are celomic metaplasia, hormonal changes, oxidative stress and inflammation, immune dysfunction, apoptosis suppression, genetic predisposition, and…

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Regret assessment in women under 35 years who underwent hysterectomy

Hysterectomy is the most common gynecological operation in women for the management of benign or malign indications. Leiomyomas, menorrhagia, endometriosis, and pain unresponsive to medical treatment can be accepted as the most common indications for hysterectomy. However, hysterectomy, as the permanent loss of child-bearing capability, has several surgical risks, intraoperative and postoperative complications. Thus, the decision of hysterectomy is very difficult, especially in women under 35 years old. Bougie et al, a group of scientists from Canada, published a study…

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Recurrent endometriosis is a real challenge both for the patients and clinicians

Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Current medical and surgical treatment options have several limitations including the side effects, costs, risk of recurrence, effects on conception capability. Recurrence is a major problem that can be encountered at various rates in different publications. It can occur due to the development of de novo lesions or to in situ growth of residual foci. Ceccaroni et al, a group of scientists from Italy,…

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The effect of endometriosis on implantation in women with endometriosis associated infertility

One of the most common clinical findings of women with endometriosis is fertility problems. Women with endometriosis often benefit from in vitro fertilization methods to get pregnant. However, whether there is a detrimental effect of endometriosis on in vitro fertilization outcomes is a controversial issue. Yevseyevich et al, a group of scientists from the Russian Federation, at the RUDN University, center of reproduction and genetics NOVA CLINIC,  published a study titled “Implantation failures in women with infertility associated endometriosis” in the journal named…

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Serum anti-Müllerian hormone levels for predicting spontaneous pregnancy after endometriosis surgery

Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Although there are several medical and surgical therapeutic options, the most effective treatment modality has not yet been elucidated.    The main objective of surgical interventions should be therapeutic and effective. There is a relationship between endometriosis and reduced ovarian reserve, decreased pregnancy rates, fertility problems. Thus, total surgical removal of the disease is very important to prevent recurrence. Ultrasonographic antral follicle…

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Is there any difference between endometriosis patients with or without obliterated cul-de-sac during laparoscopic hysterectomy?

Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. It is diagnosed in 10% to 15% of reproductive-aged women. Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Medical or surgical treatment modalities can be suggested in the management of endometriosis. Hysterectomy may be performed in women who desired complete relief of pain. Due to new technical developments, minimally invasive approaches are preferred in…

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How does pregnancy affect endometriosis?

Endometriosis is the localization of endometrial stromal and glandular cells outside the uterine cavity. Pregnancy is offered as a treatment option for patients with endometriosis because it causes atrophy of endometrial cells similar to progesterone treatment. Progesterone predominance during pregnancy, as observed before menarche or after menopause, generally leads to regression of endometriosis-associated symptoms due to the development of amenorrhea. Although there is not much evidence about the fate of endometriotic lesions and related symptoms after pregnancy, pregnancy is recommended…

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Patients preferences for the treatment of endometriosis-associated pain

Endometriosis is defined as the location of endometrial stroma and glands outside the uterine cavity. The most common presenting complaints are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility, most of which relate to the menstrual period. Those women affected by endometriosis demand therapy for the symptoms of endometriosis, notably dysmenorrhea and non-menstrual pelvic pain. Despite extensive research, the optimal management of endometriosis still remains unclear. Non-steroidal anti-inflammatory drugs, narcotics, hormonal contraceptives, progestin therapy, gonadotropin-releasing hormone (GnRH) analogs (eg, leuprolide,…

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Melatonin receptors and their role in endometrial cell proliferation

Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Despite extensive research, the exact pathophysiological mechanism and the optimal management of endometriosis still remains unclear. Management of endometriosis should aim to relieve pain, ameliorate infertility and improve quality of life. Current medical and surgical treatment options have several limitations including the side effects, costs, the risk of recurrence, and effects on conception capability. The benefit of melatonin, which is a hormone produced by…

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The accuracy of "lower endoscopic ultrasound" for the preoperative diagnosis of rectosigmoid endometriosis

Endometriosis affects reproductive-aged women most frequently with a prevalence of 5% to 15%. If the endometriotic lesions involve the bowel especially sigmoid colon and rectum, this subtype of endometriosis is named as "bowel" or "rectosigmoid" endometriosis. Rectosigmoid endometriosis is encountered in 3.8% to 37% of all women with endometriosis. Dyschezia, constipation, diarrhea, abdominal bloating, and cyclical rectal bleeding are the most common findings in women with rectosigmoid endometriosis. The differential diagnosis of rectosigmoid endometriosis from irritable bowel syndrome with similar symptoms…

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Infertility in women with endometriosis

Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. The most common presenting complaints are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Despite extensive research, the etiopathogenic mechanism underlying the two has not been fully elucidated. Although human experiments are limited for ethical reasons, animal experiments have shown that there is a causal relationship between endometriosis and infertility. This association between endometriosis and infertility seem to be multifactorial, including mechanical, molecular, genetics, and environmental aspects. Pelvic cavity factors,…

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Health care resource utilization and cost in women with endometriosis

Endometriosis is a chronic inflammatory disease affecting 6-10% of reproductive-aged women. The clinical picture of the disease range from asymptomatic findings to dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Endometriosis has also complex etiopathogenetic background. This broad clinical spectrum, the lack of understanding of the etiopathogenesis delay, make the diagnosis and treatment of the disease difficult. Despite extensive research, the optimal management of endometriosis still remains unclear. The decision for treatment should be patient-centered considering patient’s clinical presentation, age, the…

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The predictors for the coexistence of uterine leiomyomas and endometriosis

Uterine leiomyomas are the most common gynecological benign tumors affecting 20-25% of reproductive-aged women. Abnormal bleeding, pelvic pain, pelvic pressure, and infertility are major symptoms of these tumors. Endometriosis is another gynecological disease encountered in 10-15% of reproductive-aged women. The most common symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Both diseases share some common features such as estrogen dependence, similar potential symptoms, and genetic predisposition. Ultrasound and/or magnetic resonance imaging can be used for the accurate differential diagnosis.…

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The coelomic metaplasia hypothesis of endometriosis in MRKH cases

Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity and its incidence is approximately 10% in the general female population. Although the pathophysiological mechanism is not clearly understood, the implantation theory by Sampson is the most accepted hypothesis. According to the Sampson theory, endometriotic lesions develop from the endometrial cells spreading into the peritoneal cavity through Fallopian tubes during menstruation. However, retrograde menstruation occurs in most women, but the incidence of endometriosis is…

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Non‑invasive biomarkers for endometriosis diagnosis

Endometriosis is a disease of women in reproductive age and its incidence varies between 5-10%. Since the diagnosis is based on the histological confirmation, there is an average of 7 to 11 years of delays in the diagnosis. Promising non-invasive biomarkers are needed for early diagnosis and treatment of endometriosis. However, there is no biomarker with high sensitivity and specificity that has been validated in the diagnosis of endometriosis to take place in clinical use. Irungu et al, a group of…

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The genetic predisposition to endometriosis

Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. Although endometrium is a non-malignant disease, its symptoms can range from mild to severe due to the inflammation that ectopic endometrial tissue forms around itself. The exact etiopathogenetic mechanism has not been understood, although several mechanisms support the presence of a genetic predisposition. A group of scientists from Italy and Greece, led by Dr. Angioni, recently published a review entitled “Genetics of endometriosis: a comprehensive review” in the journal…

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The postoperative functional outcomes of deep infiltrating endometriosis

Rectosigmoid endometriosis is defined as the infiltration of the bowel wall with the endometrial-like glands and stroma, reaching at least the muscular layer. The most commonly involved sites are the rectum and sigmoid colon. For the management of deep infiltrating endometriosis, conservative rectal surgery by shaving or disc excision, or radical rectal surgery by segmental resection should be performed. However, there is no study identifying the predictive factors of postoperative functional outcomes in these patients. Roman et al, a group…

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The coexistence deep infiltrating endometriosis and fibromyalgia

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The main symptoms of endometriosis which are dysmenorrhea, dyspareunia, and chronic pelvic pain impair the quality of life of these women. This disease may be accompanied by some other chronic diseases such as fibromyalgia. Coloma et al, a group of scientists from Spain, published a study titled as “Prevalence of fibromyalgia among women with deep infiltrating endometriosis” in the journal named as International Journal…

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