Hale Goksever Celik, MD

Dr. Goksever Celik is an obstetrician and gynecologist, graduated from the medical school of the Hacettepe University in Ankara, and trained through Obstetrics and Gynecology fellowship at Dokuz Eylul University in Izmir. She has been a postdoctoral research fellow at Molecular Biology and Genetics at Istanbul University. She has been participating in several research especially interested in the association between endometriosis surgery and ovarian reserve and the genetic basis of endometriosis.

Does endometrioma size have an effect on IVF/ICSI outcomes?

Assisted reproductive technologies including IVF/ICSI can be suggested as the therapeutic option in women with endometriosis-associated infertility. In literature, there is a controversy regarding the influence of endometrioma size on IVF/ICSI outcomes. The group led by Drs Chapron and Santoulli from France published an article titled “Influence of endometrioma size on ART outcomes” in the journal Reproductive BioMedicine Online. The authors aimed to evaluate whether there is an impact of endometrioma size on IVF/ICSI outcomes in women having endometriosis-associated infertility. They…

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Postoperative serum markers to predict serum AMH recovery following endometriosis surgery

Women with endometriosis seek treatment including ovarian cystectomy, because of symptoms that reduce their quality of life. Ovarian cystectomy using laparoscopic or robotic devices is the preferred therapy. However, it has been shown in the literature that ovarian reserve is adversely affected after this surgical approach. Lee et al., from Korea, published a review titled “Serum anti-Müllerian hormone recovery after ovarian cystectomy for endometriosis A retrospective study among Korean women” in the journal named Medicine. The authors aimed to evaluate the…

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Endometriosis and the cumulative live birth rate in IVF cycles.

Infertility is one of the symptoms encountered in up to 40-50% of women with endometriosis. There are several pathophysiological theories suggesting the development of endometriosis-associated infertility. Assisted reproductive technology (ART) using in vitro fertilization and embryo transfer (IVF-ET) has been accepted as the most effective treatment modality for these women. However, the effect of endometriosis on IVF outcomes has not been fully elucidated. Zhou et al, from China, published a study titled “Endometriosis is associated with a lowered cumulative live birth…

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The association between severe endometriosis and venous thromboembolism

For clarifying the issue of whether endometriosis patients are at risk for venous thromboembolism due to both their local immune and inflammatory responses and hormonal treatments, Wiegers et al,  from the Netherlands, published an explorative cohort study entitled “Risk of venous thromboembolism in women with endometriosis” in the scientific journal named Thrombosis Research. The aim was to evaluate whether there is an association between severe endometriosis and venous thromboembolism. They used a risk ratio of 2 as the threshold for venous…

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Coexistence of endometriosis and cardiovascular diseases

The most common presenting complaints are mainly pelvic pain and infertility, most of which relate to the menstrual period. Affected women demand therapy for these symptoms of endometriosis, notably pelvic pain. Several theories have been proposed to explain the development of endometriosis and abnormal angiogenesis, dysregulation of apoptotic mechanisms, oxidative stress, immune dysfunction, and stem cell theory are underlying pathophysiologic mechanisms. Because of underlying complex, hormonal, inflammatory, and systemic abnormalities, it has been recognized that cardiovascular diseases and endometriosis may…

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Fallopian tube occlusion in infertile women with endometriosis

Women with endometriosis suffer from fertility problems with an incidence of 40-50%. Among the pathophysiologic mechanisms resulting in impaired fertility in women with endometriosis, distorted pelvic anatomy due to adhesions,  impaired follicular quality-quantity, dysfunction of tubal peristalsis, and implantation problems may be responsible. Mayrhofer et al, from Austria and the USA, published a study entitled “Are the Stage and the Incidental Finding of Endometriosis Associated with Fallopian Tube Occlusion? A Retrospective Cohort Study on Laparoscopic Chromopertubation in Infertile Women” in…

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Sex Education For The Sexual Quality Of Life

The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Decreased quality of life due to pelvic pain, dyspareunia, and psychological conditions such as anxiety and depression can lead to sexual dysfunction in women with endometriosis. Improving sexual functions in these women is an important part of the management of endometriosis. Matloobi et al., from Iran and Germany, published a prospective study titled “Effect of sex education on sexual function and sexual quality of life in…

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Endometriosis-associated infertility: How to manage?

Although the underlying reason for endometriosis has not been fully established, there is an association between endometriosis and infertility. Endometriosis is thought to be involved in 40-50 percent of infertility cases. However, natural conception can still occur even in women with severe endometriosis, especially in the 12-18 months following endometriosis surgery. On the other hand, surgery has a place to diagnose and treat endometriosis. Pirtea et al, from France and Switzerland, published a review study titled “Infertility workup: identifying endometriosis”…

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The effect of chronic endometritis on pregnancy outcomes in infertile women having minimal/mild endometriosis

Endometriosis is an estrogen-dependent disease that is frequently diagnosed in reproductive-aged women. Infertility can be associated with endometriosis in these women depending on several pathophysiologic mechanisms such as anatomic distortion, and implantation failure. Thus pregnancy rate is so important, especially in women who underwent an operation for endometriosis. Qiao et al., from China, published a retrospective study titled “Existence of chronic endometritis and its influence on pregnancy outcomes in infertile women with minimal/mild endometriosis” in the International Journal of Gynecology…

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Ankylosing Spondylitis and Endometriosis

There are several theories contributing the development of endometriosis: one of the proposed pathophysiological mechanisms is the abnormality in immune and inflammatory system. Several immunologic diseases coexist with endometriosis depending on the common immunologic characteristics such as Tumor necrosis Factor (TNF) and the helper T cell (Th17) pathway. Yin et al., from Taiwan, published a retrospective cohort study titled “Risk of Ankylosing Spondylitis in Patients With Endometriosis: A Population-Based Retrospective Cohort Study” in the journal named  Frontiers in Immunology. The…

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The association between inflammatory cytokines and fertility in women with endometriosis

Women with endometriosis suffer not only from a broad spectrum of symptoms including pain including dysmenorrhea, dyspareunia, and chronic pelvic pain but also fertility problems. Endometriosis-associated infertility develops depending on a combination of several mechanisms such as distorted pelvic anatomy, impaired ovarian function, altered microenvironment, affected endometrial receptivity, and embryo quality. However, we still couldn’t understand which endometriosis patient would develop infertility. Jin et al,  from China and Germany, published a study titled “Infertile women with endometriosis possess differences in…

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Does endometrioma affect ovarian reserve to reach pregnancy and birth?

Endometrioma occurs in approximately 17-44% of women with endometriosis. These women suffer from dysmenorrhea, dyspareunia, chronic pelvic pain, and also infertility. Although the exact mechanism explaining endometriosis-associated infertility has not been elucidated, distorted pelvic anatomy, impaired ovarian function, altered microenvironment-endometrial receptivity, and embryo quality has been accepted as the most common responsible mechanisms. In vitro fertilization treatments can be performed for the management of infertility in women with endometrioma. It has been known that clinical pregnancy and live birth rates were…

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Abdominal wall endometriosis is not a rare disease as supposed

Abdominal wall endometriosis is an iatrogenic type of endometriosis defined as the localization of endometrial glandular and stromal tissue on the abdominal wall including skin, the rectus abdominis muscle, and rectus muscle sheath. Cyclical pain, mass located on the abdominal wall, and a history of cesarean section or gynecologic procedures represent the classic triad of abdominal wall endometriosis. Surgical removal with negative surgical margins remains the gold standard management while medical treatment is not effective because of the connective tissue around…

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Listening to patients’ complaints is the first step on the way to a diagnosis of endometriosis.

Early diagnosis and management of endometriosis are not possible due to the wide spectrum of symptoms and absence of non-invasive diagnostic biomarkers. Particularly the adolescent population is at risk for the diagnostic delay because pelvic pain and dysmenorrhea are very common among adolescent girls. Wrobel et al, from Poland, published a study titled “Diagnostic delay of endometriosis in adults and adolescence-current stage of knowledge” in the journal named Advances in Medical Sciences. The authors aimed to evaluate the recent status of the…

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The underlying reason of implantation failure in women with endometriosis-associated infertility

Endometriosis is most frequently encountered in reproductive-aged women, with a prevalence of 10-15% in the general population. However, endometriosis is more frequently diagnosed in infertile women, with a prevalence of 25-40%. Although the exact mechanism explaining the association between endometriosis and infertility has not been elucidated, distorted pelvic anatomy, impaired ovarian function, altered microenvironment, affected endometrial receptivity, and embryo quality has been accepted as the most common responsible mechanisms. Besides fertility problems, women with endometriosis may encounter recurrent implantation failures during…

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Is "non-hormonal therapy" effective in women with endometriosis-associated pain?

Women with endometriosis require effective treatment due to the negative impact of the disease on quality of life. Hormonal treatments including oral contraceptives, and progestins are usually recommended to suppress ovulation and decrease pelvic pain. However, some women do not use these hormonal drugs regularly due to the side effects, while others are resistant to these drugs or inconvenient to use them. They continue to suffer from endometriosis-associated pain and seek other therapeutic options. Dr. DiVasta et al, from Harvard,…

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The consequences of endometriosis on the quality of life

The most common clinical findings of endometriosis patients are pelvic pain and fertility problems, resulting in impairment of quality of life. These women are affected especially during the menstruation period. Olliges et al., from Germany and Switzerland, published a study titled “The Physical, Psychological, and Social Day-to-Day Experience of Women Living With Endometriosis Compared to Healthy Age-Matched Controls—A Mixed-Methods Study” in the journal named as Frontiers in Global Women’s Health. In the study, the authors aimed to evaluate pain ratings…

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Is intrauterine insemination effective in women having endometriosis-associated infertility?

The most common presenting complaints of women with endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Affected women demand therapy for these symptoms of endometriosis, notably fertility problems. Several underlying mechanisms have been proposed to explain endometriosis-associated infertility including anatomic distortion, diminished tubal peristalsis, diminished sperm movements, dysfunctional folliculogenesis, luteal phase dysfunction, and alterations in endometrial receptivity. In vitro fertilization or intracytoplasmic sperm injection techniques have been preferred in women with moderate or severe endometriosis while intrauterine insemination with or…

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Pain alone is not a specific predictor for endometriosis diagnosis

The most common symptoms and signs of women with endometriosis include dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. However, diagnostic delay still occurs due to the broad clinical spectrum of the disease and the absence of non-invasive diagnostic biomarkers. Gordon et al., from Australia, published a study entitled “When pain is not the whole story: Presenting symptoms of women with endometriosis” in the journal "Australian and New Zealand Journal of Obstetrics and Gynaecology". The authors sought to evaluate the causes for…

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The higher the Endometriosis Fertility Index, the higher the chance of getting pregnant

The women who desire to get pregnant may also suffer from fertility problems depending on several mechanisms such as anatomic distortion, peritoneal adhesions, tubal dysfunction, impaired quality of oocytes, and impaired endometrial receptivity. One of the most important problems in women with fertility desire is whether they can get pregnant after endometriosis surgery or not. Rodrigues et al. from Brazil published a study titled “Endometriosis fertility index predicts pregnancy in women operated on for moderate and severe symptomatic endometriosis” in…

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