Hale Goksever Celik, MD

Dr. Goksever Celik is an obstetrician and gynecologist, graduated from the medical school of the Hacettepe University in Ankara, and trained through Obstetrics and Gynecology fellowship at Dokuz Eylul University in Izmir. She has been a postdoctoral research fellow at Molecular Biology and Genetics at Istanbul University. She has been participating in several research especially interested in the association between endometriosis surgery and ovarian reserve and the genetic basis of endometriosis.

Complementary and alternative therapies for managing acyclic pelvic pain in women with endometriosis

The quality of life in women with endometriosis is affected depending on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Because of different clinical spectrum and diagnostic delays, there is no optimum management method in all women with endometriosis. Expectant, medical, or surgical methods are personalized depending on the patient’s clinical presentation and gynecologic evaluation. Mongiovi et al., from the United States, published a longitudinal cohort study titled “Differences in characteristics and use of…

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Endometriosis and the risk to have mental disorders

The most common clinical findings of endometriosis patients are pelvic pain and fertility problems, resulting in impairment of quality of life. These women are also affected regarding psychological health due to disease-associated symptoms. Dr. Wang et al., from Taiwan, published a study titled “Association Between Endometriosis and Mental Disorders Including Psychiatric Disorders, Suicide, and All-Cause Mortality-A Nationwide Population-Based Cohort Study in Taiwan” in the International Journal of Women’s Health. In this study, the authors aimed to evaluate whether there was any…

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The effect of medical treatment on sexual function and quality of life in women with endometriosis

Women with endometriosis suffer from dysmenorrhea, dyspareunia and chronic pelvic pain, all of which has significant negative consequences on their physical and psychological health regarding sexual function, work and social relationships. Biasioli et al. from Italy, published an article entitled “Does Sexual Function and Quality of Life Improve after Medical Therapy in Women with Endometriosis? A Single-Institution Retrospective Analysis” in the Journal of Personalized Medicine. The authors aimed to evaluate whether there is an impact of medical treatment on quality of…

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Novel high-risk candidate genes for familial endometriosis

Endometriosis is a chronic inflammatory disease with a genetic background resulting in familial clustering. Although multiple susceptibility loci have been identified in genome-wide association studies, high-risk predisposing variants have not been defined yet. A group of scientists from Finland, published a study en titled “Whole‑exome sequencing reveals candidate high‑risk susceptibility genes for endometriosis” in the journal Human Genomics. The authors aimed to determine high-risk candidate genes for familial endometriosis and to assess the association of endometriosis with high-grade serous carcinoma. A Finnish family…

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A non-invasive test to determine the risk of endometriosis in women having chronic pelvic pain or unexplained infertility

Women having endometriosis may suffer from chronic pelvic pain and/or infertility, both of which diminish the quality of life in these women. Minimalization of the time between the onset of symptoms and diagnosis is essential to improve patients’ lives. However, there is a delay of approximately 4-11 years from the development of symptoms to diagnosis due to the absence of reliable and non-invasive screening test. Dr.Nezhat et al., from the USA, published a retrospective cross-sectional study entitled “Use of the…

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The type of surgical approach compared to complications and recurrence for colorectal endometriosis

Women with endometriosis may have extension and infiltration of the intestine, called "colorectal endometriosis, in up to 12%. The main symptoms are alterations in bowel habits, pelvic pain, and/or infertility. The gold standard management option for colorectal endometriosis is surgical removal of all endometriotic lesions resulting in healthy, disease-free margins. However, the intra- and postoperative complications can be experienced frequently due to dense adhesions and deep pelvic involvement. Dr. Christiansen et al. from the USA published a systematic review entitled…

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No increased risk of major postoperative complications in women operated by experienced surgeons in endometriosis centers

Recurrent surgery may be needed in up to 35% of endometriosis patients. The reason for repeated surgery may be residual or recurrent disease. In other words, multiple surgical procedures are a common phenomenon for women having endometriosis. Knowing the impact of previous surgeries on subsequent surgeries is so important to provide correct counseling to the patient and to make preoperative planning. Tummers et al. from Netherlands published a study titled “Evaluation of the effect of previous endometriosis surgery on clinical…

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Underestimation of Dysmenorrhea in adolescents

Women with endometriosis may suffer from painful symptoms, especially during menstruation or sexual intercourse. One of the main etiologic reasons for secondary dysmenorrhea is endometriosis, and it has a poor impact on life quality. Underestimation of dysmenorrhea and consideration of dysmenorrhea as a normal and transient symptom in adolescents and young women may result in delayed diagnosis and management of endometriosis. Martire et al., from Italy, published a review entitled “Endometriosis and Adolescence: The Impact of Dysmenorrhea” in the Journal of…

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Endometriosis and Physical Activity

Endometriosis causes abstinence from their daily life, especially during painful periods. Decreased physical function might result in reduced physical activity. Sachs et al., from Switzerland, published a study titled “Physical Activity in Women with Endometriosis: Less or More Compared with a Healthy Control?” in the International Journal of Environmental Research and Public Health. The authors aimed to investigate the effect of endometriosis on physical activity, compared to women without any suspicious signs of endometriosis in this multi-center, cross-sectional study. Demographic and…

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Treatment of superficial dyspareunia using topical estrogens in postmenopausal women with a history of endometriosis

Genitourinary syndrome of menopause is defined as a collection of symptoms and signs caused by hypoestrogenic changes to the labia majora/minora, clitoris, vestibule/introitus, vagina, urethra, and bladder that occur in menopausal patients. Sexual dysfunction and superficial dyspareunia can be experienced by postmenopausal women resulting in decreased quality of life. Hormonal or non-hormonal treatments (lubricants/moisturizers) may be prescribed to manage vulvovaginal atrophy-associated superficial dyspareunia. It should be known that there are some special populations, such as women with a history of endometriosis:…

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Preoperative flexible sigmoidoscopy in patients with deep infiltrating endometriosis

Deep infiltrating endometriosis is defined as endometriotic lesions extending 5 mm or more below the peritoneal surface. Women with deep endometriosis have rectovaginal lesions affecting the tissue adjacent to, or directly involving the rectum and/or rectosigmoid colon with a 90% incidence. Deep endometriosis may be diagnosed or suspected with transvaginal ultrasound or magnetic resonance imaging in experienced hands. Routine flexible sigmoidoscopy is suggested in cases with suspicious rectovaginal deep endometriosis. Sewell et al., from the United Kingdom, published a study titled “The…

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Moderate-to-severe Endometriosis and "The Cumulative live birth rate" in IVF Cycles

Infertility is one of the major symptoms in women with endometriosis. The incidence of endometriosis is approximately 10% in reproductive-aged women and up to 40-50% in infertile women. There are multifactorial mechanisms resulting in endometriosis-associated infertility such as anatomic distortion, impaired tubal and sperm motility, and diminished endometrial receptivity. Dr. Zimmermann et al, from France, published a study titled “Impact of moderate-to-severe endometriosis on IVF cumulative live birth rate: a retrospective matched cohort study” in the journal "Reproductive BioMedicine Online". The…

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Are women with endometriosis more prone to pregnancy loss?

Endometriosis is a gynecological disease of reproductive-aged women who may suffer from reproductive outcomes such as infertility, miscarriage, and recurrent pregnancy loss. Pregnancy loss is the spontaneous loss of a pregnancy until 22 weeks of gestation including spontaneous abortion, missed abortion, and gestational sac without a fetus; while recurrent pregnancy loss is defined as three consecutive pregnancy losses. Dyhrberg Boje et al, and associates from Denmark, published a study titled “Endometriosis is associated with pregnancy loss: a nationwide historical cohort…

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Endometriosis and Genetic Polymorphisms in Proinflammatory Cytokines

Several pathophysiological mechanisms have been proposed for the chronic inflammatory nature of endometriosis, such as retrograde menstruation, coelomic metaplasia, hormonal change, oxidative stress and inflammation, immune dysfunction, and apoptosis suppression. One of the most widely accepted theories in recent years is inflammatory dysfunction and genetic polymorphism. Babah et al., a research group from Nigeria and the UK, published a study titled “Serum concentrations of IL‑16 and its genetic polymorphism rs4778889 affect the susceptibility and severity of endometriosis in Nigerian women”…

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Changes over time in day surgery for endometriosis in Canada

There are several medical and surgical treatment options for the management of endometriosis. Surgical approach is generally preferred in women with atypical endometrioma appearance on ultrasound, and who have persistent pain despite medical treatment. Surgery is often the first choice for endometriomas with rapid increase in size. Bahrami et al., from Canada, published a study titled “Day surgery for endometriosis in Canada: A retrospective cohort of trend and regional variation in types of surgeries and their complications” in the journal…

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Meningioma risk in women with endometriosis using Nomegestrol acetate

Women with endometriosis mostly suffer from symptoms such as chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility. Early diagnosis and management have importance as endometriosis impairs the quality of life and creates a serious social and economic burden. There are different medical treatment options including only progestogens, oral contraceptives, or gonadotropin-releasing agonists/antagonists. Combined oral contraceptives are a good modality if women request contraception or progestogen monotherapy is associated with breakthrough bleeding or bone mineral density reduction. The standard progestogen in oral…

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Does ovarian endometrioma affect embryo aneuploidy rate in fertile women?

One of the most common clinical findings of women with endometriosis is the decline in fertility status. These women often benefit from in vitro fertilization methods to become pregnant. However, whether there is a detrimental effect of endometriosis on oocyte and embryo development following in vitro fertilization treatments is a controversial issue. A group of scientists under the leadership of Dr. Yuan from China published a study titled “Ovarian endometrioma increases the embryo aneuploid rate: an analysis of 7092 biopsied blastocysts…

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The effect of dienogest vs ethynyl estradiol/dienogest on quality of life in women with endometriosis

Women with endometriosis suffer from dysmenorrhea, dyspareunia, and chronic pelvic pain that diminishes the quality of their life. Both physical and mental components of quality of life have been affected by endometriosis-associated symptoms. There are several medical and surgical treatment options to manage these women. However, none may provide a permanent solution to increase the quality of life. Maiorana et al. from Italy published an observational single-center study titled “Quality of life and clinical factors in women with endometriosis, the…

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Endometriosis diet and the quality of life

Women with endometriosis suffer mainly from pelvic pain which results in a negative effect on the quality of life. Although several treatment options have been proposed, some endometriosis patients still have poor quality of life due to pelvic pain. Upon this, research has begun to evaluate the benefits of the gluten- and sugar-free endometriosis diet. van Haaps and colleagues from the Netherlands published a study entitled “A better quality of life could be achieved by applying the endometriosis diet: a cross-sectional…

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The #Enzian classification, an essential tool for surgical management of severe endometriosis

The lecture entitled "The #Enzian classification, an essential tool for surgical management of severe endometriosis" was presented by Professor. Jörg Keckstein, from the University Ulm, Germany, at the Annual International Medical Conference of the Endometriosis Foundation of America held in New York on April 1-2, 2023. Endometriosis is a disease that requires classification due to the heterogeneous and complex nature of the disease. Such a classification system will also enable communication between clinicians, surgeons, and patients. The Revised American Society for Reproductive Medicine…

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