Hale Goksever Celik, MD

Dr. Goksever Celik is an obstetrician and gynecologist, graduated from the medical school of the Hacettepe University in Ankara, and trained through Obstetrics and Gynecology fellowship at Dokuz Eylul University in Izmir. She has been a postdoctoral research fellow at Molecular Biology and Genetics at Istanbul University. She has been participating in several research especially interested in the association between endometriosis surgery and ovarian reserve and the genetic basis of endometriosis.

Postmenopausal endometriosis: Is it a rare phenomenon?

Endometriosis, the estrogen-dependent disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity, is generally diagnosed in the reproductive-aged women. However, recent literature proved that this disease can also be observed in the premenopausal and postmenopausal periods. Secosan et al, scientists from Romania and France, published a review titled “Endometriosis in Menopause—Renewed Attention on a Controversial Disease” in the journal named "Diagnostics". The authors aimed to evaluate postmenopausal endometriosis in all aspects, including the prevalence,…

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Maternal body mass index and neonatal outcomes in women with endometriosis

Endometriosis is defined as the localization of endometrial glandular and stromal-like tissue outside the uterine cavity. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of 25-40%.  Infertility in women with endometriosis is managed most commonly by assisted reproductive technology (ART) modalities. The recent literature provides controversial data about the obstetric outcomes of in vitro fertilization treatments in patients with endometriosis. The increased risk of preterm…

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Recurrence following surgery for subtypes of endometriosis

Endometriosis is a disease identified by the location of endometrial stromal and glandular cells outside the uterine cavity. It is considered as a gynecological disease of reproductive-aged women. Three subtypes of endometriosis are peritoneal endometriosis which defines the endometriotic lesions located on the peritoneal surface, ovarian endometrioma which are the cysts with chocolate-like content located in the ovaries, and deep infiltrating endometriosis which defines the endometriotic lesions situated more than 5 mm deep to the peritoneum. There are several treatment…

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Fertility preservation protocols in women with endometriosis

Infertility is one of the major symptoms in women with endometriosis. Childbearing at a delayed age is preferred by the majority of women recently who consult for the demand for fertility preservation procedures. There are several techniques for fertility preservation such as ovarian cortex cryopreservation, freezing of embryos and oocyte cryopreservation that has been accepted as the best option due to lower negative impact on ovarian reserve and lower associated morbidity. Although there are many publications about the outcomes of fertility…

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The predictive factors for early spontaneous miscarriage in IVF/ICSI cycles

The most common presenting complaints of endometriosis are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Affected women demand therapy for these symptoms of endometriosis, notably fertility problems. The clinical pregnancy rate has increased up to 60% in assisted reproductive technology (ART) clinics due to the developments of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) techniques. However, unfortunate obstetric outcomes such as biochemical pregnancy, ectopic pregnancy, spontaneous miscarriage, and stillbirth may be experienced resulting in decreased live birth…

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The genetic mutations in uterine adenomyosis

Adenomyosis is defined as the localization of endometrial stromal and glandular cells in the myometrium. This disease is a reproductive-aged women disease, like endometriosis. Additionally, adenomyosis is frequently observed together with endometriosis and leiomyomas due to common histological features and molecular changes. However, these diseases show some differences according to their pathogenesis, localization of the lesions and clinical features. Underlying etiopathogenetic mechanisms of adenomyosis have not been understood clearly despite several proposed theories. As in many diseases, it is thought…

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The role of microbiota in the etiopathogenesis of endometriosis

Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. Although many advanced types of research about the etiology, differential diagnosis and treatment have been performed, it still remains an enigmatic disease. Dr. Bedaiwy, a scientist and physician from Canada, published a study titled “Endometrial macrophages, endometriosis, and microbiota: time to unravel the complexity of the relationship” in the journal named "Fertility and Sterility". The role of infectious, inflammatory and immunological changes in the etiopathogenesis of endometriosis is…

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A review of endometriosis in adolescent girls and young women

Endometriosis is an estrogen-dependent disease which is commonly diagnosed in reproductive-aged women. On the other hand, this disease can develop earlier in life due to different etiopathogenetic mechanisms. Especially adolescents who experienced neonatal uterine bleeding are under the risk for endometriosis. Gałczyński et al, a group of scientists from Poland, published a mini-review titled as “Ovarian endometrioma – a possible finding in adolescent girls and young women: a mini-review” in the journal named as Journal of Ovarian Research. They aimed…

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The association between endometriosis and ectopic pregnancy

Endometriosis is a chronic inflammatory disease with a broad spectrum of symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain and fertility problems. It has been understood in the light of scientific evidence that endometriosis is also associated with other poor obstetric outcomes including early and late pregnancy complications. Ectopic pregnancy is a complication of pregnancy in which the embryo attaches outside the uterus. Yong et al, a group of scientists from Canada, published a review titled “Endometriosis and Ectopic Pregnancy:…

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Endometriosis and ovarian reserve

Endometriosis is most frequently encountered in reproductive-aged women. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of 25-40%. Although the exact mechanism explaining the association between endometriosis and infertility has not been elucidated, distorted pelvic anatomy, impaired ovarian function, altered microenvironment, affected endometrial receptivity, and embryo quality been accepted as the most common responsible mechanisms. Infertility in women with endometriosis is managed most commonly by assisted…

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Recent advances in the diagnosis and treatment of endometriosis

Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. The most common complaints of women with endometriosis are pain and fertility problems. Although many advanced types of research about the etiology, differential diagnosis and treatment have been performed, it remains a still enigmatic disease. The most commonly accepted theory which explains the development of endometriosis is retrograde menstruation theory. Other theories are celomic metaplasia, hormonal changes, oxidative stress and inflammation, immune dysfunction, apoptosis suppression, genetic predisposition, and…

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Regret assessment in women under 35 years who underwent hysterectomy

Hysterectomy is the most common gynecological operation in women for the management of benign or malign indications. Leiomyomas, menorrhagia, endometriosis, and pain unresponsive to medical treatment can be accepted as the most common indications for hysterectomy. However, hysterectomy, as the permanent loss of child-bearing capability, has several surgical risks, intraoperative and postoperative complications. Thus, the decision of hysterectomy is very difficult, especially in women under 35 years old. Bougie et al, a group of scientists from Canada, published a study…

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Recurrent endometriosis is a real challenge both for the patients and clinicians

Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Current medical and surgical treatment options have several limitations including the side effects, costs, risk of recurrence, effects on conception capability. Recurrence is a major problem that can be encountered at various rates in different publications. It can occur due to the development of de novo lesions or to in situ growth of residual foci. Ceccaroni et al, a group of scientists from Italy,…

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The effect of endometriosis on implantation in women with endometriosis associated infertility

One of the most common clinical findings of women with endometriosis is fertility problems. Women with endometriosis often benefit from in vitro fertilization methods to get pregnant. However, whether there is a detrimental effect of endometriosis on in vitro fertilization outcomes is a controversial issue. Yevseyevich et al, a group of scientists from the Russian Federation, at the RUDN University, center of reproduction and genetics NOVA CLINIC,  published a study titled “Implantation failures in women with infertility associated endometriosis” in the journal named…

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Serum anti-Müllerian hormone levels for predicting spontaneous pregnancy after endometriosis surgery

Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Although there are several medical and surgical therapeutic options, the most effective treatment modality has not yet been elucidated.    The main objective of surgical interventions should be therapeutic and effective. There is a relationship between endometriosis and reduced ovarian reserve, decreased pregnancy rates, fertility problems. Thus, total surgical removal of the disease is very important to prevent recurrence. Ultrasonographic antral follicle…

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Is there any difference between endometriosis patients with or without obliterated cul-de-sac during laparoscopic hysterectomy?

Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. It is diagnosed in 10% to 15% of reproductive-aged women. Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Medical or surgical treatment modalities can be suggested in the management of endometriosis. Hysterectomy may be performed in women who desired complete relief of pain. Due to new technical developments, minimally invasive approaches are preferred in…

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How does pregnancy affect endometriosis?

Endometriosis is the localization of endometrial stromal and glandular cells outside the uterine cavity. Pregnancy is offered as a treatment option for patients with endometriosis because it causes atrophy of endometrial cells similar to progesterone treatment. Progesterone predominance during pregnancy, as observed before menarche or after menopause, generally leads to regression of endometriosis-associated symptoms due to the development of amenorrhea. Although there is not much evidence about the fate of endometriotic lesions and related symptoms after pregnancy, pregnancy is recommended…

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Patients preferences for the treatment of endometriosis-associated pain

Endometriosis is defined as the location of endometrial stroma and glands outside the uterine cavity. The most common presenting complaints are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility, most of which relate to the menstrual period. Those women affected by endometriosis demand therapy for the symptoms of endometriosis, notably dysmenorrhea and non-menstrual pelvic pain. Despite extensive research, the optimal management of endometriosis still remains unclear. Non-steroidal anti-inflammatory drugs, narcotics, hormonal contraceptives, progestin therapy, gonadotropin-releasing hormone (GnRH) analogs (eg, leuprolide,…

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Melatonin receptors and their role in endometrial cell proliferation

Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Despite extensive research, the exact pathophysiological mechanism and the optimal management of endometriosis still remains unclear. Management of endometriosis should aim to relieve pain, ameliorate infertility and improve quality of life. Current medical and surgical treatment options have several limitations including the side effects, costs, the risk of recurrence, and effects on conception capability. The benefit of melatonin, which is a hormone produced by…

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The accuracy of "lower endoscopic ultrasound" for the preoperative diagnosis of rectosigmoid endometriosis

Endometriosis affects reproductive-aged women most frequently with a prevalence of 5% to 15%. If the endometriotic lesions involve the bowel especially sigmoid colon and rectum, this subtype of endometriosis is named as "bowel" or "rectosigmoid" endometriosis. Rectosigmoid endometriosis is encountered in 3.8% to 37% of all women with endometriosis. Dyschezia, constipation, diarrhea, abdominal bloating, and cyclical rectal bleeding are the most common findings in women with rectosigmoid endometriosis. The differential diagnosis of rectosigmoid endometriosis from irritable bowel syndrome with similar symptoms…

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