Hale Goksever Celik, MD
Dr. Goksever Celik is an obstetrician and gynecologist, graduated from the medical school of the Hacettepe University in Ankara, and trained through Obstetrics and Gynecology fellowship at Dokuz Eylul University in Izmir. She has been a postdoctoral research fellow at Molecular Biology and Genetics at Istanbul University. She has been participating in several research especially interested in the association between endometriosis surgery and ovarian reserve and the genetic basis of endometriosis.
Recognizing Adolescent Endometriosis: Early, Intense, and Atypical
Adolescents experiencing pelvic pain often face delayed or missed diagnoses due to atypical symptoms of endometriosis. Unlike in adults, their pain may not follow classic patterns, making it harder to recognize and treat the disease early. In a recent prospective study, the authors led by Dr.Porpora from Italy examined differences in symptom profiles and treatment responses between adolescents (ages 12–18) and adult women with endometriosis. The study, published in the Journal of Clinical Medicine, highlighted striking distinctions in how endometriosis…
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Quality of Life in Patients with Urinary Tract Endometriosis
Urinary tract endometriosis (UTE) is a specific form of endometriosis that affects the urinary system, most commonly the bladder or urethra. It can cause symptoms such as bladder irritation, urinary urgency, painful urination (dysuria), blood in the urine (hematuria), and loin pain near the kidneys. Pain, a hallmark of endometriosis, often disrupts daily activities, work, and overall quality of life. Beyond physical symptoms, women with UTE may also experience significant emotional distress related to concerns about fertility and surgical outcomes, leading…
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Multidisciplinary approach in endometriosis patient management
Women with endometriosis suffer from pelvic pain such in terms of dysmenorrhea, dyspareunia or infertility, all of which significantly negatively impact quality of life, and increase the risk of mental health disorders. Hartnett et al., a research team from Ireland, have published a systematic review protocol titled “Cross-disciplinary working between gynaecologists and mental healthcare professionals: a mixed-methods systematic review” in the BMJ Open. The review aims to explore the clinical need for integrated mental healthcare in the context of gynecological conditions…
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The Role of Surgeon Specialty in Colorectal Resection Outcomes for Women with Endometriosis
When endometriosis invade the tissues, including the bowel wall by more than 5 mm, it is termed deep infiltrating endometriosis. Patients with bowel involvement typically experience symptoms such as constipation, diarrhea, tenesmus, and rectal bleeding. Surgical intervention is often the primary treatment option for these patients, offering significant improvements in pain, infertility, and digestive issues. Both gynecologists and general/colorectal surgeons are capable of performing this procedure. A study by Nasseri et al., published in Colorectal Disease, sought to explore whether…
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Exploring the Impact of NNMT Enzyme on Endometriosis
Endometriosis is driven largely by inflammation and immune dysfunction. Despite extensive research, the optimal treatment for endometriosis remains uncertain. A better understanding of the disease's mechanisms could lead to improved therapies and a better quality of life for affected women. A recent study by Hou et al., titled "Overexpressed Nicotinamide N‑methyltransferase in Endometrial Stromal Cells Induced by Macrophages and Estradiol Contributes to Cell Proliferation in Endometriosis", published in Cell Death Discovery, investigated the role of nicotinamide N‑methyltransferase (NNMT) in endometriosis.…
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May it be a new non-hormonal treatment option for endometriosis patients?
Heidi Ledford published a news in Nature, entitled “How understudied endometriosis causes pain for hundreds of millions of women”. She aimed to summarize the recent status about endometriosis treatment options. Pain-sensing nerves and immune cells interact to worsen both pain and lesion growth in endometriosis. In a study published in Science Translational Medicine, researchers found that the protein CGRP, which mediates communication between these cells, contributes to both the sensation of pain and the progression of lesions in a mouse…
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Predictive factors for decline in postoperative serum AMH levels following endometrioma surgery
Women with endometrioma seek treatment because of symptoms such as pelvic pain and infertility that reduce their quality of life. There are several management approaches including medical and surgical options. Ovarian cystectomy using laparoscopic or robotic devices is one of the preferred therapy in endometrioma patients, especially having untreatable pain with medical options. However, it has been known that ovarian reserve is adversely affected following surgical treatment of endometriomas. Mak et al., from Taiwan, published a review article titled “Factors…
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Postoperative Outcomes in Women After Sacral Plexus Deep Endometriosis Resection
Deep endometriosis refers to a severe form of endometriosis where tissue grows deeply into the pelvic and abdominal organs, including the bowel, bladder, nerves, and blood vessels. When the disease affects the sacral plexus, which is a network of nerves at the base of the spine, it can lead to severe nerve pain, known as sacral radiculopathy. This occurs when the endometriotic lesions compress, irritate, or invade the sacral nerve roots (S1-S4) or the fibers of the sciatic nerve. Women with sacral radiculopathy…
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Lifestyle and Environmental Factors in Endometriosis: Current Insights and Future Directions
Endometriosis-associated symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain have an effect to diminish the quality of life. The physical and mental quality of life of these women is adversely affected. There are several studies evaluating the quality of life and environmental factors in endometriosis patients. Researchers in the U.S., led by Lalla et al., recently published a review titled "Impact of Lifestyle and Dietary Modifications for Endometriosis Development and Symptom Management" in Current Opinion in Obstetrics and Gynecology. This review focuses on…
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Does endometriosis have an adverse effect on sperm activity?
Infertility is one of the symptoms encountered in up to 40-50% of women with endometriosis. There are several pathophysiological theories suggesting the development of endometriosis-associated infertility such as altered pelvic anatomy, adhesions, disrupted ovarian reserve/function and compromised endometrial receptivity as well as systemic effects of the disease. There is limited evidence about the effect of sperm activity on endometriosis-associated infertility. Fenner A., published a research highlight entitled as “Sperm activity affected by endometriosis” in the Nature Reviews Urology. The author…
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Gluten-free diet fot endometriosis-associated gastrointestinal symptoms
Women with endometriosis often report gastrointestinal symptoms such as bloating, constipation, diarrhea, and abdominal cramping,may have a negative impact on women’s lives having endometriosis and which can mimic irritable bowel syndrome (IBS) leading to potential misdiagnosis. A commonly suggested dietary intervention is a gluten-free diet, often promoted on social media. While effective for conditions like non-celiac wheat sensitivity or celiac disease, its impact on endometriosis remains uncertain. vanHaap et al., from The Netherlands, published a study titled as “A gluten-free…
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Effects of Endometriosis Symptoms on Women's Overall Health and Well-Being
Endometriosis significantly affects women's quality of life. Many women face daily challenges due to pelvic pain, which can lead them to miss work or school and withdraw from social activities. It's crucial to assess and manage the symptoms associated with endometriosis to avoid these serious consequences. However, symptoms can vary widely among individuals. A group of Australian researchers led by Mitchell et al. published a study titled “The Most Impactful Endometriosis Symptom” in the journal Acta Obstetricia et Gynecologica Scandinavica.…
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Does a comprehensive interventional program improve sexual health in women with endometriosis?
Women with endometriosis suffer from dysmenorrhea, dyspareunia and chronic pelvic pain, all of which has significant negative consequences on their physical and psychological health regarding sexual and reproductive function. A group of scientists from Iran, published a study protocol titled “A comprehensive interventional program to improve the sexual function of women with endometriosis: a mixed‑methods protocol study” in the journal Reproductive Health. The authors aimed to evaluate whether there is an impact of the interventional programs on sexual function in reproductive-aged…
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Menstrual Health & Endometriosis Education Increases the Awareness in Students
The main symptoms of endometriosis include dysmenorrhea, dyspareunia, and chronic pelvic pain that may result in social and developmental disturbances such as abstinence from school or work. There is a significant diagnostic delay of endometriosis diagnosis, because symptoms may be ignored by both patients and clinicians. A group of researchers led by Dr.Yong, from Canada, published a study titled “Does Menstrual Health and Endometriosis Education Affect Knowledge Among Middle and Secondary School Students? A Cluster-Randomised Controlled Trial” in Journal of…
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Laparoscopic procedures can alleviate fatigue in women suffering from endometriosis
The most common symptoms of endometriosis include pelvic pain, dysmenorrhea, dyspareunia, and infertility. Effective management is essential due to the significant impact these symptoms have on a woman's quality of life. Fatigue, characterized by persistent and severe tiredness, is also linked to various chronic conditions, including rheumatological diseases and cancer. Reischer and colleagues from Austria published a study titled “Can Laparoscopic Surgery Reduce Fatigue in Women with Endometriosis? - A Pilot Study” in the Journal of Clinical Medicine. The…
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Endometriosis and musculoskeletal function of pelvic loin complex
Endometriosis is an inflammatory and estrogen-dependent disease which is diagnosed in reproductive-aged women most frequently. These women present with a broad clinical spectrum including pelvic pain, dysmenorrhea, dyspareunia and infertility. All of these symptoms and signs may harm women’s lives having endometriosis. Because of peripheral hypersensitivity, these women may have musculoskeletal dysfunction located in the pelvic loin complex. Silva de Barros et al., from Brazil, published a study titled as “Musculoskeletal evaluation of the lower pelvic complex in women…
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Diminished physical activity in women with endometriosis due to chronic pelvic pain
Endometriosis is a systemic, chronic, inflammatory disease defined as the localization of endometrial-like tissue outside the uterine cavity. Pelvic pain is the most common symptom in these women resulting in abstinence from school or work and psychosocial problems. Physical activity is also impaired in these women as repeated experiences of intense pain causing central sensitization in the brain. Some modifications in their physical ability to perform physical tasks have been observed in endometriosis patients. Researchers from Brazil, published a study…
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Endometriosis-associated symptoms have a negative impact on the quality of life in women
Women with endometriosis experience restrictions in their daily activities due to pelvic pain, resulting in abstinence from work or school and discontinuation of their social activities. Evaluation and management of endometriosis-associated symptoms is important to prevent these significant consequences. However, successful intervention may change between and within individuals depending on the individual's presentation and needs. Mitchell et al. from Australia, published a study titled “The “most bothersome symptom” construct: A qualitative study of Australians living with endometriosis” in the journal Acta…
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Dysmenorrhea in adolescent girls and the quality of life
Dysmenorrhea, also known as period pain, painful periods, or menstrual cramps, is pain during menstruation. Despite its high incidence, dysmenorrhea is often a stigmatized and normalized condition. However, it is known that painful periods cause abstinence from work or school resulting in decreased quality of daily life. Cameron et al. from Australia, published a study titled “Menstrual pain in Australian adolescent girls and its impact on regular activities: a population-based cohort analysis based on Longitudinal Study of Australian Children survey…
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Programmed Cell Death 1 Ligand Expression and Endometrioma Recurrence
Although there are several medical and surgical management options, endometriosis is highly prone to recurrence. A possible predictor of recurrence would be the quality of life for women with endometriosis. On the other hand, endometriosis is an immunological disease, there are many publications in the literature supporting this situation. Programmed cell death-1, expressed on the surface of activated T cells, B cells, and other lymphocytes, binds specifically with PD-L1 which has an immunosuppressive role by inhibiting T-cell activity. The interaction between…
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