Hale Goksever Celik, MD
Dr. Goksever Celik is an obstetrician and gynecologist, graduated from the medical school of the Hacettepe University in Ankara, and trained through Obstetrics and Gynecology fellowship at Dokuz Eylul University in Izmir. She has been a postdoctoral research fellow at Molecular Biology and Genetics at Istanbul University. She has been participating in several research especially interested in the association between endometriosis surgery and ovarian reserve and the genetic basis of endometriosis.
Postoperative pregnancy outcomes in women with deep infiltrating endometriosis
Subperitoneal invasion of endometriotic lesions exceeding 5 mm in depth is named "deep infiltrating endometriosis' and can be located on uterosacral ligaments, in the intestine, vagina, bladder, and ureter. Women with deep infiltrating endometriosis suffer from pelvic pain and infertility most commonly and demand treatment to increase the quality of their life. Although management is individualized depending on the patient’s symptoms and pregnancy wish, the first-line treatment is hormonal therapy, especially in women with pelvic pain. However, medical treatment has no…
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Comparison of different IVF stimulation protocols for pregnancy success in infertile endometriosis patients
Women with endometriosis may suffer from reproductive problems up to an incidence of 50%. Several pathophysiological mechanisms including anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis and sperm movements are the most responsible for the development of endometriosis-associated infertility. Assisted reproduction technology (ART) is the most frequently preferred treatment approach in infertile women with endometriosis. There are different protocols for ovarian stimulation during in vitro fertilization (IVF) treatment. Wang et al, from China, published a study titled “Is the long-acting…
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Conventional IVF or ICSI: Which one is more accurate in endometriosis-related infertility?
Although the prevalence of endometriosis is 10-15% in the general population at reproductive age, it is diagnosed more frequently in infertile women with a prevalence of 25-40%. Although the exact mechanism explaining the association between endometriosis and infertility has not been elucidated, distorted pelvic anatomy, impaired ovarian function, altered microenvironment, affected endometrial receptivity and embryo quality have been proposed as the responsible mechanisms. Infertility in women with endometriosis is managed most commonly by assisted reproductive technology (ART) modalities including in…
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The most common gynecologic admissions to the emergency: Endometriosis and adenomyosis
Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Adenomyosis occurs when the endometrial glandular and stromal tissue grows into the muscular wall of the uterus, called the myometrium. Women having adenomyosis also suffer from pelvic pain and heavy or prolonged menstrual bleeding. Medical or surgical treatment modalities can be suggested in the management of both endometriosis and adenomyosis. Dr. Xholli et al. from Italy published a study titled “Gynaecological pathologies leading to emergency…
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Sexual function in infertile women with PCOS and endometriosis
Women with endometriosis suffer from several symptoms and signs including dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility which have a detrimental effect on their quality of life. Sexual dysfunction also is a common problem for endometriosis patients due to complex biological, psychological, social, and ethical issues. Polycystic ovary syndrome (PCOS), which is the most common endocrinological disease in reproductive-aged women also negatively affects sexual health. Daneshfar et al., from Iran, published a cross-sectional study titled “Comparison of sexual function in infertile…
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Endometriosis and the body perception
The most common endometriosis-associated symptoms are pelvic pain, dysmenorrhea, dyspareunia, and infertility. Women with endometriosis should be managed due to the significant impact of these symptoms on their quality of life. Body perceptions of these women are also affected depending on the visual and functional effects of the disease. A group of scientists from Australia, published a brief research report entitled “Endometriosis and body image: Comparing people with and without endometriosis and exploring the relationship with pelvic pain” in the…
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Do combination GnRH antagonists improve endometriosis-associated pain?
Endometriosis is a chronic inflammatory disease with a broad spectrum of pain symptoms such as dysmenorrhea, dyspareunia, and chronic pelvic pain. It has been understood in light of scientific evidence that endometriosis results in diminished quality of life in these women as these symptoms cause abstinence from school, work, or social interactions. Although there are several treatment options, researchers are in search of an effective treatment modality suitable for long-term use with minimal side effects. In endometriosis-associated pain management, step-by-step…
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Opioid use following operation for endometriosis or pelvic pain
Women with endometriosis have pain in the form of dysmenorrhea, dyspareunia, and chronic pelvic pain, and they have a diminished quality of life depending on the severity of pelvic pain. Opioids have been preferred in many patients suffering from pain, especially during the postoperative period. However, awareness about the overprescription of opioids due to their side-effect profile has recently increased among both clinicians and patients. Heres et al. from the USA published an original article entitled “Opioid Use After Laparoscopic…
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Does endometrioma size have an effect on IVF/ICSI outcomes?
Assisted reproductive technologies including IVF/ICSI can be suggested as the therapeutic option in women with endometriosis-associated infertility. In literature, there is a controversy regarding the influence of endometrioma size on IVF/ICSI outcomes. The group led by Drs Chapron and Santoulli from France published an article titled “Influence of endometrioma size on ART outcomes” in the journal Reproductive BioMedicine Online. The authors aimed to evaluate whether there is an impact of endometrioma size on IVF/ICSI outcomes in women having endometriosis-associated infertility. They…
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Postoperative serum markers to predict serum AMH recovery following endometriosis surgery
Women with endometriosis seek treatment including ovarian cystectomy, because of symptoms that reduce their quality of life. Ovarian cystectomy using laparoscopic or robotic devices is the preferred therapy. However, it has been shown in the literature that ovarian reserve is adversely affected after this surgical approach. Lee et al., from Korea, published a review titled “Serum anti-Müllerian hormone recovery after ovarian cystectomy for endometriosis A retrospective study among Korean women” in the journal named Medicine. The authors aimed to evaluate the…
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Endometriosis and the cumulative live birth rate in IVF cycles.
Infertility is one of the symptoms encountered in up to 40-50% of women with endometriosis. There are several pathophysiological theories suggesting the development of endometriosis-associated infertility. Assisted reproductive technology (ART) using in vitro fertilization and embryo transfer (IVF-ET) has been accepted as the most effective treatment modality for these women. However, the effect of endometriosis on IVF outcomes has not been fully elucidated. Zhou et al, from China, published a study titled “Endometriosis is associated with a lowered cumulative live birth…
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The association between severe endometriosis and venous thromboembolism
For clarifying the issue of whether endometriosis patients are at risk for venous thromboembolism due to both their local immune and inflammatory responses and hormonal treatments, Wiegers et al, from the Netherlands, published an explorative cohort study entitled “Risk of venous thromboembolism in women with endometriosis” in the scientific journal named Thrombosis Research. The aim was to evaluate whether there is an association between severe endometriosis and venous thromboembolism. They used a risk ratio of 2 as the threshold for venous…
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Coexistence of endometriosis and cardiovascular diseases
The most common presenting complaints are mainly pelvic pain and infertility, most of which relate to the menstrual period. Affected women demand therapy for these symptoms of endometriosis, notably pelvic pain. Several theories have been proposed to explain the development of endometriosis and abnormal angiogenesis, dysregulation of apoptotic mechanisms, oxidative stress, immune dysfunction, and stem cell theory are underlying pathophysiologic mechanisms. Because of underlying complex, hormonal, inflammatory, and systemic abnormalities, it has been recognized that cardiovascular diseases and endometriosis may…
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Fallopian tube occlusion in infertile women with endometriosis
Women with endometriosis suffer from fertility problems with an incidence of 40-50%. Among the pathophysiologic mechanisms resulting in impaired fertility in women with endometriosis, distorted pelvic anatomy due to adhesions, impaired follicular quality-quantity, dysfunction of tubal peristalsis, and implantation problems may be responsible. Mayrhofer et al, from Austria and the USA, published a study entitled “Are the Stage and the Incidental Finding of Endometriosis Associated with Fallopian Tube Occlusion? A Retrospective Cohort Study on Laparoscopic Chromopertubation in Infertile Women” in…
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Sex Education For The Sexual Quality Of Life
The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Decreased quality of life due to pelvic pain, dyspareunia, and psychological conditions such as anxiety and depression can lead to sexual dysfunction in women with endometriosis. Improving sexual functions in these women is an important part of the management of endometriosis. Matloobi et al., from Iran and Germany, published a prospective study titled “Effect of sex education on sexual function and sexual quality of life in…
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Endometriosis-associated infertility: How to manage?
Although the underlying reason for endometriosis has not been fully established, there is an association between endometriosis and infertility. Endometriosis is thought to be involved in 40-50 percent of infertility cases. However, natural conception can still occur even in women with severe endometriosis, especially in the 12-18 months following endometriosis surgery. On the other hand, surgery has a place to diagnose and treat endometriosis. Pirtea et al, from France and Switzerland, published a review study titled “Infertility workup: identifying endometriosis”…
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The effect of chronic endometritis on pregnancy outcomes in infertile women having minimal/mild endometriosis
Endometriosis is an estrogen-dependent disease that is frequently diagnosed in reproductive-aged women. Infertility can be associated with endometriosis in these women depending on several pathophysiologic mechanisms such as anatomic distortion, and implantation failure. Thus pregnancy rate is so important, especially in women who underwent an operation for endometriosis. Qiao et al., from China, published a retrospective study titled “Existence of chronic endometritis and its influence on pregnancy outcomes in infertile women with minimal/mild endometriosis” in the International Journal of Gynecology…
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Ankylosing Spondylitis and Endometriosis
There are several theories contributing the development of endometriosis: one of the proposed pathophysiological mechanisms is the abnormality in immune and inflammatory system. Several immunologic diseases coexist with endometriosis depending on the common immunologic characteristics such as Tumor necrosis Factor (TNF) and the helper T cell (Th17) pathway. Yin et al., from Taiwan, published a retrospective cohort study titled “Risk of Ankylosing Spondylitis in Patients With Endometriosis: A Population-Based Retrospective Cohort Study” in the journal named Frontiers in Immunology. The…
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The association between inflammatory cytokines and fertility in women with endometriosis
Women with endometriosis suffer not only from a broad spectrum of symptoms including pain including dysmenorrhea, dyspareunia, and chronic pelvic pain but also fertility problems. Endometriosis-associated infertility develops depending on a combination of several mechanisms such as distorted pelvic anatomy, impaired ovarian function, altered microenvironment, affected endometrial receptivity, and embryo quality. However, we still couldn’t understand which endometriosis patient would develop infertility. Jin et al, from China and Germany, published a study titled “Infertile women with endometriosis possess differences in…
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Does endometrioma affect ovarian reserve to reach pregnancy and birth?
Endometrioma occurs in approximately 17-44% of women with endometriosis. These women suffer from dysmenorrhea, dyspareunia, chronic pelvic pain, and also infertility. Although the exact mechanism explaining endometriosis-associated infertility has not been elucidated, distorted pelvic anatomy, impaired ovarian function, altered microenvironment-endometrial receptivity, and embryo quality has been accepted as the most common responsible mechanisms. In vitro fertilization treatments can be performed for the management of infertility in women with endometrioma. It has been known that clinical pregnancy and live birth rates were…
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