Hale Goksever Celik, MD

Dr. Goksever Celik is an obstetrician and gynecologist, graduated from the medical school of the Hacettepe University in Ankara, and trained through Obstetrics and Gynecology fellowship at Dokuz Eylul University in Izmir. She has been a postdoctoral research fellow at Molecular Biology and Genetics at Istanbul University. She has been participating in several research especially interested in the association between endometriosis surgery and ovarian reserve and the genetic basis of endometriosis.

The coexistence deep infiltrating endometriosis and fibromyalgia

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The main symptoms of endometriosis which are dysmenorrhea, dyspareunia, and chronic pelvic pain impair the quality of life of these women. This disease may be accompanied by some other chronic diseases such as fibromyalgia. Coloma et al, a group of scientists from Spain, published a study titled as “Prevalence of fibromyalgia among women with deep infiltrating endometriosis” in the journal named as International Journal…

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Preoperative factors to predict unresponsiveness in women undergoing endometriosis surgery

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Despite extensive research, the optimal management of endometriosis still remains unclear. Several treatment options include analgesic medication, hormonal treatments, and surgical intervention. There is still a risk of relapse despite extensive surgery for endometriosis. Ghai et al, a group of scientists from the United Kingdom, published a study titled as “Identifying pre-operative Factors Associated with Non-Responders in Women Undergoing Comprehensive Surgical Treatment for Endometriosis”…

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The appearance of postoperative endometriosis by imaging methods

Endometriosis is a chronic gynecological disease mostly encountered in reproductive-aged women. Endometriosis can occur in three different entities: peritoneal, ovarian and deep endometriosis. Golden standard diagnosis is made by histopathological examination of surgical material after laparoscopic surgery in women with suspicious symptoms. Although there are several medical treatment options for endometriosis, surgery remains the most important and necessary part of the treatment algorithm. Postoperative follow-up plays a vital role to determine the development of postoperative complications and/or recurrence. Guerra et…

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The miscarriage rate in women with endometriosis undergoing IVF fresh cycles

Endometriosis is a chronic estrogen-dependent disease diagnosed in 25-40% of women with infertility. There are several mechanisms explaining the negative impacts of endometriosis on fertility through the entire reproductive process such as sperm-oocyte interaction, ovarian reserve, and implantation. Endometriosis is also associated with poor obstetric outcomes including preterm birth, intrauterine growth restriction, and babies’ small for gestational age. Miscarriage is the most common obstetric complication in the first trimester. In the literature, there are controversial studies about the association between…

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Which comes first in endometriosis management: In vitro fertilization or surgery?

Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence is found to be 7%–10%, but among infertile women, it increases up to 50%. Early diagnosis and personalized management are important to improve fertility outcomes. Although there are several treatment strategies, there is no clear consensus about the definitive approach. Surgery or IVF can be suggested as the first approach in the management of endometriosis. Lessey et al, a group of scientists…

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The association between the development of endometriosis and dietary habits

Endometriosis is a chronic disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence is found to be approximately 10% in the general population. Endometriosis is associated with infertility, pelvic pain, and increased risks for ovarian and other cancers. Delay in clinical diagnosis has been reported due to the asymptomatic presentation of the disease at the early stages. Although there are several treatment strategies, there is no clear consensus about the definitive approach…

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Endometriosis and female pelvic pain in all aspects

Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence of the disease ranges between 6-10% in reproductive-aged women. However, endometriosis is more frequently encountered in women with chronic pelvic pain and infertility. The symptoms including dysmenorrhea, dyspareunia, chronic pelvic pain can be variable in patients with endometriosis. Because symptoms have a significant impact on their quality of life, early diagnosis and personalized management will be beneficial. Kim et al, a group…

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Surgical techniques for rectosigmoid endometriosis, and functional outcomes

Rectosigmoid endometriosis is defined as the infiltration of bowel wall with the endometrial-like glands and stroma, reaching at least the muscular layer. Rectosigmoid endometriosis is encountered in approximately 8-12% of patients with a diagnosis of endometriosis. The most commonly involved sites are the rectum and sigmoid colon. There is still no clear consensus about the management of rectosigmoid endometriosis, although there are different surgical methods including rectal shaving, discoid resection, and segmental rectosigmoid resection. Mabrouk et al, a group of…

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Endometriosis-associated pain control by contraceptive implant or intrauterine system

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The most common symptoms are dysmenorrhea, dyspareunia, and chronic pelvic pain, all of which affect the quality of women’s lives. Several studies investigating the efficacy of levonorgestrel-releasing intrauterine system on endometriosis-associated pelvic pain have been performed. However, the etonogestrel-releasing contraceptive implant as an alternative for this purpose has not been adequately evaluated. Carvalho et al.,  from Brazil,  along with a group of scientists lead by Dr.…

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Pelvic pain, congenital genital tract anomalies and endometriosis

Any failure during development and differentiation of female genital tract results in congenital tract anomalies. The origin of the hymen is the union of the caudal portion of the paramesonephric ducts and the urogenital sinus. It functions as a mechanical barrier to infections during infancy. If the central portion of the hymen does not rupture before birth, it becomes imperforate, micro-perforated, septate or cribriform. These girls are often asymptomatic until menarche. Then the vagina becomes distended with the accumulation of…

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Are women with histologically confirmed endometriosis satisfied with their medical support?

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The most common symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, dyschesia, dysuria, musculoskeletal pain, fatigue and infertility, all of which affect the quality of women’s lives. Most women with endometriosis experience a diagnostic delay of 10 years on average. The most important reason for this delay is the patient’s dissatisfaction. Lukas et al, a group of scientists from Switzerland, Germany and Austria published a…

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How to predict natural conception in women underwent endometriosis surgery?

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The most common symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. The prevalence of endometriosis increases in the infertile population. Thus, the important issue for most women is the probability of getting pregnant,  especially following endometriosis surgery. Several classification and scoring systems have been introduced to clinicians’ use, one of the most frequently used is the rAFS score. However, this scoring system cannot be…

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Is Physical Exercise Effective in Endometriosis?

Endometriosis is defined as the localization of endometrial tissue outside the uterine cavity. Dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility are mostly encountered symptoms of endometriosis. Although there are several theories explaining the pathogenesis of endometriosis, the exact pathogenesis still has not been understood. Based on the hypothesis of inflammatory predisposition, the physical activity is thought to have a beneficial effect on endometriosis. Montenegro et al, a group of scientists from Brazil, published an animal study titled as “Effect of Physical…

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Can MRI be used to detect anterior pelvic endometriotic lesions?

Deep infiltrating endometriosis is the most severe manifestation of endometriosis. It is defined as the infiltration of ectopic endometrial tissue under the peritoneum, pelvic structures, and the organ walls such as the uterosacral ligaments, colon, vagina, bladder, ureter, rectovaginal septum, and the lateral parametrium. Only 6% of deep infiltrating endometriosis is located in the anterior compartment of the pelvis including vesicouterine space, the detrusor and the uterus. Although laparoscopy remains the gold standard for diagnosis of anterior pelvic endometriosis, transvaginal…

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Three dimensional sono-vaginography to diagnose rectovaginal endometriosis

Deep infiltrating endometriosis is defined as the localization of ectopic endometrial tissue penetrating more than 5 mm into the affected pelvic organs. Rectovaginal endometriosis is the most severe form of deep infiltrating endometriosis in which ectopic endometrial tissue infiltrating rectum and posterior vaginal fornix extends to the rectovaginal septum, and this form is the most difficult to diagnose. Laparoscopic biopsy and histopathological confirmation are accepted as the gold standard for the diagnosis of endometriosis. However, the structures where the disease…

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Non-assisted reproductive technology treatment: Is it effective in infertile patients with advanced endometriosis?

The marriage and childbearing ages delay due to the life-style changes in developed countries. As a result, advanced age becomes a major concern in infertility treatments which consist of non-ART and ART modalities. Non-ART treatments include mild ovarian stimulation together with timed intercourse and/or intrauterine insemination, whereas ART treatments include in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Isono et al, a group of scientists from Tokyo, published a retrospective study titled as “The efficacy of non-assisted reproductive technology…

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Parametrial endometriosis: A harder form of endometriosis

Deep infiltrating endometriosis is the most severe manifestation of endometriosis, affecting 20% of all patients with endometriosis. It is defined as the infiltration of ectopic endometrial tissue under the peritoneum, pelvic structures, and the organ walls such as the uterosacral ligaments, colon, vagina, bladder, ureter, rectovaginal septum, and the lateral parametrium. Lateral parametrium covers the retroperitoneal connective tissue from the uterus to the lateral pelvic wall. If endometriosis spread to the parametrium, the surgical intervention plays a major role in…

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How to preserve fertility in women with “ovarian endometriosis”?

Although there are many treatment modalities in endometriosis, optimal treatment has not been developed yet. The aim of the treatment is to reduce pain, to preserve and improve fertility and to delay recurrence. Ovarian ischemic and perfusion damage during endometriosis surgery is an important concern to be considered by clinicians. Because ovarian reserve has already decreased due to the presence of endometriosis, surgery should be considered even more carefully. Donnez et al, a group of scientists from Belgium, published a…

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Transvaginal ultrasound for "rectosigmoid endometriosis" diagnosis: Is bowel preparation necessary?

Rectosigmoid endometriosis is a severe form of deep endometriosis. Women having rectosigmoid endometriosis present with pain and several intestinal complains such as constipation, diarrhea, intestinal cramping, abdominal bloating, feeling of incomplete evacuation, the passage of mucus and rectal bleeding during the menstrual period. Transvaginal ultrasound (TVS) is the first line diagnostic method for the detection of rectosigmoid endometriosis. This non-invasive method is also cheaper, easier to tolerate than other methods such as rectal endoscopic sonography, magnetic resonance imaging. Some clinicians…

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Vitamin C supplementation in the patients with endometriosis undergoing in vitro fertilization-embryo transfer

Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Women having endometriosis present with dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Thus, infertility remains a significant problem for women with endometriosis. Endometriosis is considered as a complicated chronic inflammatory process associated with an imbalance between oxidative stress and antioxidant response. The role of oxidative stress in the pathogenesis of endometriosis has been the subject of research in recent publications. It has been shown…

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