Demet Candaş Green

Demet is an editorial coordinator at the University of California, Davis (UC Davis) responsible for editing and reviewing scientific elements of grant proposals. She holds a BS and an MS degree in Molecular Biology and Genetics from Boğaziçi University, Turkey; and a PhD in Biochemistry and Molecular Biology from UC Davis. She trained as a post-doctoral scholar at the UC Davis Comprehensive Cancer Center before she launched a career as a scientific editor. 

Using social media to raise awareness for endometriosis

Raise your hand if you have used internet or social media to search for information today. We all do, every single day. Whether it is a recipe, biography of a favorite singer, reviews of a new restaurant, or today’s weather, we increasingly rely on the internet and social media for information and support. Literature shows that 80% of internet users search for health-related information such as physicians, healthcare providers, and symptoms and treatment options for diseases. In 2016, Facebook reported…

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Impact of hemostatic techniques used in endometrioma surgery on ovarian function

This publication reports on an ongoing clinical trial that aims to assess whether the hemostatic techniques (methods to stop bleeding) used in ovarian endometrioma surgery have damaging effects on ovarian function. The clinical trial stemmed from a multitude of inconclusive studies suggesting some hemostatic methods may result in reduced ovarian reserves; while other studies suggest the damage to ovarian reserves are a natural result of having the disease itself. Given the laparoscopic surgery is the gold standard for the treatment…

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Pregnancy with endometriosis

Current literature suggests that complications of endometriosis during pregnancy are rare; however, a non-negligible increase in the likelihood of placenta accreta (placenta grows too deeply into the uterine wall), preterm birth, and cesarean delivery has been reported. With the increase in the pregnancy rates in women with endometriosis, it became integral to fully understand any possible effects of endometriosis on pregnant women and newborns. This recent study by Dr. Uccella and colleagues focused on this very concern: Maternal and neonatal outcomes…

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MRI or TVS for accurate diagnosis of rectosigmoid endometriosis?

Rectosigmoid endometriosis (RE) is seen in about 90% of patients with bowel endometriosis. Rectosigmoid is the region between the rectum and the sigmoid colon, which is a region easily accessed and assessed by two most common noninvasive imaging modalities – transvaginal sonography (TVS) or magnetic resonance imaging (MRI). Either method was found, by this study, highly accurate for noninvasive diagnosis and pre-operative mapping of RE. Noninvasive means of diagnosis is treasured by patients with deep endometriosis, as they generally go…

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Surgical treatment of deeply infiltrating endometriosis in tertiary treatment centers

In the present study, data from patients who were surgically treated for deep infiltrating endometriosis (DIE) in a tertiary referral unit, the Avicenna Centre for Endometriosis and Minimally Invasive Gynecology (ACEMIG, Tehran, Iran), were examined for rates of intraoperative and postoperative complications. This observational study included 244 women, aged 15–55, who underwent laparoscopic surgery to DIE at ACEMIG between September 2013 and August 2016. "ACEMIG" is one of the very few referral centers for women with severe endometriosis in Iran…

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Endocrine-disrupting chemicals – yet another environmental factor associated with endometriosis?

This study by Wen et al., published in Gynecological Endocrinology, analyzed evidence connecting endocrine-disrupting chemicals (EDCs) to the incidence of endometriosis in a collection of 30 previously published studies. Results show that exposure to many EDC's are linked to the risk of endometriosis. However, the number of studies (30) is quite small for accurate conclusions. Well-designed epidemiology studies can confirm this suspected linkage. EDCs are substances in our environment, food or consumer products that induce hormone dysregulation in humans or…

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Bladder Endometriosis

Bladder endometriosis is rare – about 1-2% of women with endometriosis may have endometrial lesions in their urinary tract. Diagnosis of bladder endometriosis is difficult because of its nonspecific symptoms such as frequent urination, pelvic pain, and burning sensation when urinating, which are also symptoms of ever so common cystitis. This recent study by Gonçalves et al., published in "Surgical Technology International" in March 2019 analyzed the available data from patients with bladder endometriosis with a goal of understanding the…

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Can early-life exposures affect endometriosis development later in life?

Endometriosis is a complex disease with possible multifactor contributors. So far, inflammatory, immunogenic, genetic, and environmental factors have all been associated with endometriosis. In addition, it is possible that different types of endometriosis lesions – peritoneal, ovarian, and deep infiltrating – may all have different origins and pathogenic mechanisms. A recent multi-country study called FEELING (Factors associated with the development of Endometrioma and dEep infiltratING endometriosis) investigated the clinical, lifestyle, and environmental factors associated with all three subtypes of endometriosis…

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Gal-3 can be a pharmacological target in endometriosis treatment

Galectins are known to play a significant role in angiogenesis, which is a key event contributing to the development of many disease conditions, one of which is endometriosis. Past studies, upon examining several human endometriotic lesions, showed that Galectin-3 (Gal-3) was overexpressed in the endometrium of women with endometriosis compared to that of women without endometriosis; and in peritoneal as well as deep infiltrating endometriotic lesions. These findings formed the basis of the current study, which investigated a possible role…

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Self-management of endometriosis symptoms: from Australia

Effective self-management techniques and lifestyle changes may play an important role in the management of endometriosis symptoms by many women. Due to various reasons such as limited effectiveness of some medications, potential side effects, availability of medical resources, self-desire to take more control over own health; many women might turn to self-care strategies for management of their endometriosis symptoms. This study by Armour et al. aimed to determine the kinds of self-management strategies used by women with endometriosis. By surveying…

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Bowel endometriosis: What you need to know

When the endometrial tissue infiltrates the intestinal walls and reaches inside the intestines, this condition is called "bowel endometriosis". It is estimated that between 3.8% and 37% of women with endometriosis are affected by bowel endometriosis. The endometriosis lesions infiltrating intestines can have different characteristics such as the number and size, how deeply the intestinal wall is infiltrated, and what percentage of the intestines are affected. All of these characteristics contribute to the symptoms observed and treatment strategies adopted. While…

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HOXA-10 levels are related to infertility in endometriosis patients

The current study by Ozcan et al., published in the European Journal of Obstetrics & Gynecology and Reproductive Biology aimed to investigate the levels of HOXA-10 gene in fertile versus infertile women with endometriosis. HOXA-10 protein (expressed by HOXA-10 gene) is normally elevated in human endometrium during implantation and its levels increase dramatically during the mid-secretory phase of the menstrual cycle, which roughly corresponds to Day18 to Day25 of a normal menstrual cycle. According to the present study, the HOXA-10 levels…

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The effect of endometriosis on preterm birth risk

Some studies show that women with endometriosis develop significant complications during pregnancy that lead to preterm labor, and newborns of these women often need neonatal intensive care unit admissions. However, other studies argue that endometriosis have no significant effect on pregnancy outcomes. This current study by Perez-Lopez et al. aimed to evaluate the association between endometriosis and preterm birth risk in pregnant women with endometriosis either spontaneously conceived or used ART. Also studied are several secondary outcomes such as the…

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Does asthma increase the risk of endometriosis?

Previous studies have shown an association between asthma and endometriosis but with inconsistency. It is still unclear whether women who have asthma are at a higher risk of endometriosis than women without asthma symptoms. Peng et al., conducted a large nationwide retrospective study, studied data from Taiwan National Health Insurance Database identified 7,337 women aged 12-50 years with newly diagnosed asthma or using asthma medications, and 29,348 age-matched women without asthma in an attempt to investigate the association between asthma…

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Body Mass Index and IVF outcomes in non-obese endometriosis patients

Endometriosis and body mass index (BMI) are inversely related, meaning obese women are at a lower risk of developing endometriosis. Similarly, women with lower BMI are considered high risk for severe types of endometriosis. The severity of endometriosis brings about lower reproductive chances. All of these facts indicate higher BMI among women with endometriosis may lead to an increased reproductive outcome in these patients. Garalejic et al. investigated the effect of BMI on in vitro fertilization (IVF) outcomes in endometriosis…

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Can grapefruits and oranges be used for treatment of endometriosis?

Naringenin is a plant-based nutrient found abundantly in grapefruits and oranges with well-known anti-cancer, anti-inflammatory, and anti-oxidant properties. Previous studies showed that naringenin could modify the estrogen receptor signaling, suggesting a role for naringenin in endometriosis. The current study performed by Park et al., from College of Life Sciences and Biotechnology, Korea University, Seoul, aimed to investigate whether naringenin affects the viability of endometriosis cells, and identify the signaling molecules that mediate naringenin’s effects on these cells. The authors utilized several techniques…

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Stress affects endometriosis negatively

Stress contributes to many chronic health problems – endometriosis is one of them. Given that women with endometriosis are under more stress and pain, often with the added stress of infertility, it is important to understand the relationship between stress and the development of endometriosis, which could lead to the identification of therapeutic strategies that alleviate stress in endometriosis patients and slow the progress of their disease.It was previously shown that stress promoted the growth of endometriotic lesions, and luckily,…

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Gestational diabetes risk in women with endometriosis

Gestational diabetes (GD) is a common complication in pregnancy with several negative consequences for both mother and baby.  The risk of developing GD increases with maternal age and body mass index (BMI). Women with endometriosis conceive later than fertile women, a fact that may contribute to the increased risk of GD in women with endometriosis. However, studies of GD risk in women with endometriosis have shown contradictory results. Dr. Perez-Lopez et al. from Zaragoza, Spain, carried out a systematic review to…

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Treatment of minimal endometriosis in infertile women

For women with mild/minimal endometriosis, European Society of Human Reproduction and Embryology (ESHRE) recommends the removal of endometriotic lesions to improve fertility and increase pregnancy rates. For women undergoing assisted reproductive treatment, there is ongoing debate whether surgical removal of endometriosis improves reproductive outcomes. Although ESHRE guidelines state that surgical removal of the lesions can be considered before assisted reproductive treatment, they acknowledge that the benefit of surgery is not well established in these cases. This paper discusses the available…

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Progesterone resistance can cause endometriosis

Progesterone is a steroid hormone produced by the corpus luteum of ovaries. Abnormal progesterone signaling (i.e., progesterone resistance) in the endometrium has been implicated in the establishment of eutopic and ectopic endometrial implants. Several causes for faulty progesterone signaling have been suggested: (1) congenial – resulting from maternal and neonatal preconditioning, which means newborn progesterone resistance may persist through adolescence; (2) inflammation – as progesterone action is crucial for decreasing inflammation in the endometrium; (3) retrograde menses – via peritoneal inflammation;…

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