Ayse Ayhan
Endometriosis Immunopathology: The Macrophage Connection
Macrophages and tiny signaling particles called extracellular vesicles (EVs) are emerging as central immune players in how endometriosis develops and persists. Together, they shape the immune environment around endometriotic lesions, helping them survive, spread, and resist the body’s defenses. In a recent review published in the Journal of Ovarian Research, Dr. Azari-Dolatabad from the Department of Biology, Science and Research from Islamic Azad University, Tehran-Iran, and colleagues from Belgium and USA, bring together the latest findings on the crosstalk between macrophages,…
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Novel Biomarkers for Endometriosis via Anoikis Gene Profiling
Endometriosis is notoriously difficult to diagnose early. Currently, diagnosis often requires surgery, leading to years of delay. A new study published in Biochemical Genetics introduces a potential breakthrough: the use of "anoikis-related genes" — genes linked to a form of programmed cell death that occurs when cells detach from their normal environment. In endometriosis, resistance to anoikis may allow displaced cells to survive and implant in new sites, fueling disease progression. In this study, researchers used machine learning algorithms to…
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Deep Learning Models for Object Detection in Laparoscopic Endometriosis Surgery
For endometriosis treatment, surgery remains the cornerstone, but its success depends heavily on the surgeon’s ability to detect and completely excise lesions. Some endometriotic lesions can be subtle, hidden, or resemble surrounding tissue, which increases the risk of incomplete surgery and recurrence. In a study recently published in Diagnostics, researchers explored whether artificial intelligence could support surgeons by improving lesion detection during laparoscopy. They developed a custom dataset of laparoscopic images of endometriosis, annotated by clinical experts, and trained two…
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