Endometriosis and the sexual relations of the couples

Endometriosis and  the sexual relations of the couples By Selma Oransay

From the viewpoint of endometriotic women, the pain during the penetration is not the only complaint. They also have growing depression and anxiety leading to difficulties with their social and sexual relationship, work, and study. The emotional impact of sub-infertility,…

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A Possible genetic target for endometriosis treatment

A Possible genetic target for endometriosis treatment By Dr. Youngran Park

Mutations in the chromosome remodeling complex SWI/SNF subunit ARID1A were first identified in ovarian clear-cell carcinoma and ovarian endometrioid carcinoma, two endometriosis-associated epithelial ovarian cancer subtypes. ARID1A gene mutations are also observed in deep ovarian and deep infiltrating endometriosis, atypical endometrial…

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Endometriosis involving the Sacral Plexus and Sciatic Nerve

Endometriosis involving the Sacral Plexus and Sciatic Nerve By Irem Onur

Endometriosis rarely involves the sacral and sciatic nerves. A retrospective analysis led by Rouen University Hospital, France and Aarhus University Hospital, Denmark, published in the Journal of Minimally Invasive Gynecology, has evaluated preoperative complaints, intraoperative findings, surgical procedures, and postoperative…

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Endometrioma size and anti-Müllerian hormone levels

Endometrioma size and anti-Müllerian hormone levels By Hale Goksever Celik

Endometriotic lesions are encountered in different locations in the pelvic cavity, including but not limited to the ovaries, the pouch of Douglas, the ureters, the bladder, and the bowel. Cystic endometriosis lesions located in the ovary are called "endometrioma". Endometriomas have…

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Does hysterectomy bring a total relief in patients with endometriosis?

Does hysterectomy bring a total relief in patients with endometriosis? By Bahar Yuksel

There is a common belief that hysterectomy is the last option to relieve the pain in patients with endometriosis by stopping the production of menstrual material. The study entitled "Impact of hysterectomy on analgesic, psychoactive and neuroactive drug use in…

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Pelvic MRI, Endometriosis and Radiologist

Pelvic MRI, Endometriosis and Radiologist By Murat Osman

Endometriosis is a condition whereby ectopic endometrial cells implant themselves onto other structures within the body. Depending on where these lesions are, their size, and if they cause symptoms, surgical intervention may be warranted. Although the gold standard for diagnosing…

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How to unveil the discrepancy regarding the effect of chemicals on the etiology of endometriosis

How to unveil the discrepancy regarding the effect of chemicals on the etiology of endometriosis By Nasuhi Engin Aydin

Kristen Upson from Michigan State University published a review article evaluating research papers on environmental factors effective in endometriosis from an epidemiological perspective in "Current Epidemiology Reports". Endometriosis is a multifactorial disease with anatomical, hormonal, immunological, estrogenic, genetic, epigenetic, and…

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Endometriosis and chronic opioid use

Endometriosis and chronic opioid use By Selma Oransay

The members of the American College of Obstetricians and Gynecologists have declared that gynecologists prescribe opioids after laparoscopic hysterectomy, or for relieving endometriosis pain, although guidelines are not available for when or how to use opioids for the treatment of endometriosis-associated…

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Adolescent endometriosis: Diagnostic clues?

Adolescent endometriosis: Diagnostic clues? By Irem Onur

The rates of dysmenorrhea, dyspareunia, and heavy menstrual bleeding in adolescents showing endometriosis signs on ultrasound are significantly higher compared to those without. This is according to a retrospective observational study recently published in the journal "Fertility and Sterility". The…

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Reduced risk of "small for gestational age baby" following frozen embryo transfer in endometriosis patients

Reduced risk of By Hale Goksever Celik

Infertility is encountered frequently in patients with endometriosis. These women could be managed using assisted reproductive technology (ART) including in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) to achieve pregnancy. However, some adverse obstetric and perinatal outcomes are experienced more…

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Endometrial fluid analysis as a new diagnostic test for endometriosis diagnosis

Endometrial fluid analysis as a new diagnostic test for endometriosis diagnosis By Bahar Yuksel

There is still a huge demand for finding a minimally invasive diagnostic test for endometriosis and yet none has been defined properly. The present study which was conducted in Cleveland Clinic by Natalia C. Llarena et al between March 2017…

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Comparison of diagnostic accuracy of imaging modalities for the deep infiltrating endometriosis

Comparison of diagnostic accuracy of imaging modalities for the deep infiltrating endometriosis By Selma Oransay

The treatment of deeply infiltrated endometriosis (DIE) is usually personalized and the potential success for the available therapeutical options is dependent on early and accurate diagnosis. Laparoscopy is the gold standard for the diagnosis of DIE. Other non-invasive diagnostic methods…

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Endometriosis and adenomyosis could be the “sides of the same coin”.

Endometriosis and adenomyosis could be the “sides of the same coin”. By Nasuhi Engin Aydin

The two common gynecological disorders, namely adenomyosis, and endometriosis are not settled yet, whether they are representing two different entities or different phenotypes of the same ailment. Dr. Maruyama and colleagues from Nara, Japan searched PubMed and Google Scholar electronic…

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Endometriosis and Natural Killer Cell Immunity

Endometriosis and Natural Killer Cell Immunity By Dr. Youngran Park

It is known that approximately 25 to 50% of infertile women have endometriosis, and 30% to 50% of the women with endometriosis have infertility and recurrent pregnancy loss. Previous studies have shown that women suffering endometriosis have abnormal NK cell…

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Magnetic resonance imaging classification for the management of deep pelvic endometriosis

Magnetic resonance imaging classification for the management of deep pelvic endometriosis By Irem Onur

A new study published in the journal "Human Reproduction" reported that operating time, hospital stay, and postoperative complications in patients who underwent surgery for deep endometriosis can be predicted by the MRI. This result may be useful for clinicians to…

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Combination of noninvasive biomarkers in the identification of endometriosis

Combination of noninvasive biomarkers in the identification of endometriosis By Timur Seckin

The combined measurement of urine enolase, serum CA125, and CA19-9 may be an accurate test for the prediction and detection of endometriosis. This is according to a study published in the journal BioMedical Research International. The gold standard for the…

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Patients' opinion about surgical treatment of endometriosis

Patients' opinion about surgical treatment of endometriosis By Selma Oransay

Delayed diagnosis and management of endometriosis and chronic pelvic pain is a major problem in gynecologic practice. Alternatively, providers may feel reluctant to perform surgery although they are aware of treatment options and surgical timing. One possible reason for this…

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Segmental bowel resection could be predicted using MRI in patients with rectal endometriosis

Segmental bowel resection could be predicted using MRI in patients with rectal endometriosis By Hale Goksever Celik

The rectum and recto-sigmoid junction are the preferential localisations of bowel endometriosis. The three main surgical approaches are shaving, disc excision, and segmental resection. It is very important to decide the most appropriate surgical method preoperatively and to plan accordingly. …

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Can a grape ingredient, resveratrol, be the promised warrior to defeat endometriosis?

Can a grape ingredient, resveratrol, be the promised warrior to defeat endometriosis? By Bahar Yuksel

Endometriosis is a chronic estrogen-dependent disorder and has a known relationship with angiogenesis, inflammation, and oxidative stress. Resveratrol is a part of a "polyphenol" compound which are thought to act like antioxidants, protects the body against damage. This compound is normally…

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Dyspareunia and Endometriosis

Dyspareunia and Endometriosis By Irem Onur

Women experience severe pain during intercourse related to endometriosis and this has a significant negative impact on the lives of women. This is according to an American study published in the "Journal of Pain Research". The study included 638 endometriosis…

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Bad bad lipid go away!

Bad bad lipid go away! By Yu Yu

Much like the progression of endometriosis, accumulating evidence suggests that systemic chronic inflammation and oxidative stress can contribute to atherosclerosis. The excess low-density lipoprotein increases inflammatory processes in the arteries, which may result in atherosclerosis. Previous studies have shown that…

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Indocyanine green in endometriosis surgery

Indocyanine green in endometriosis surgery By Selma Oransay

Recently, indocyanine green is well studied and used safely in real-time perfusion to organs or tissues, after taking into consideration its binding capacity to the plasma proteins. The usefulness and the effectiveness of near-infrared camera guided indocyanine green is proved with…

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Osteopontin and Endometriosis

Osteopontin and Endometriosis By Dr. Youngran Park

Although characterized as a benign disease, some properties of endometriosis mimic malignant tissues such as proliferation, cell invasion, and metastasis. Osteopontin, also called secreted phosphoprotein 1, is one of the important molecular targets in cancer progression and metastasis. Osteopontin has been…

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It is time for non-invasive tests for peritoneal endometriosis diagnosis

It is time for non-invasive tests for peritoneal endometriosis diagnosis By Nasuhi Engin Aydin

Maria Szubert with colleagues from Lodz Medical University, Poland, investigated the possibility of potential diagnostic biomarkers in the eutopic endometrial tissue from peritoneal endometriosis patients and published their results in the "Journal of Gynecology Obstetrics and Human Reproduction". Currently, diagnostic…

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Psychometric properties of Endometriosis Health survey-Swedish version

Psychometric properties of Endometriosis Health survey-Swedish version By Hale Goksever Celik

Endometriosis is a chronic estrogen-dependent disease resulting in a broad spectrum of symptoms and signs including dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Additionally, gastrointestinal and urinary systems may be affected by this disease. All of these clinical findings impair…

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Fallopian tube endometriosis

Fallopian tube endometriosis By Bahar Yuksel

Endometriosis affects various tissues including pelvic and extra-pelvic organs. Fallopian tube endometriosis is not a widely studied topic in endometriosis, hence the real incidence is unknown as not all studies evaluate microscopically diagnosed Fallopian tube endometriosis. In the retrospective database…

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Non-coding RNAs and Endometriosis

Non-coding RNAs and Endometriosis By Ellen Tumimbang

Non-coding RNAs may have a fundamental role in the development of endometriosis. Non-coding transcripts have regulatory roles in the expression of protein-coding genes, thus regulate several signaling pathways. Based on their length, these non-coding RNAs are classified into two main classes:…

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Body mass index, the incidence of endometriosis and the severity of dysmenorrhoea

Body mass index, the incidence of endometriosis and the severity of dysmenorrhoea By Timur Seckin

According to a case-control study conducted by researchers from China, there is no association between body mass index (BMI) and the incidence of endometriosis. This finding contrasts with the conventional knowledge that low BMI is a risk factor for endometriosis.…

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An animal model of endometriosis reveals stress related disturbed vitamin D - vitamin D receptor axis

An animal model of endometriosis reveals stress related disturbed vitamin D - vitamin D receptor axis By Nasuhi Engin Aydin

Lopez and colleagues from academic institutions of Puerto Rico published their experimental endometriosis findings on female rats regarding the effect of stress on vitamin D-vitamin D receptor systems and recently published their findings in "Reproductive Sciences". The group previously showed…

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The peculiarity of adolescent endometriosis

The peculiarity of adolescent endometriosis By Selma Oransay

Recent studies showed the prevalence of endometriosis in adolescents with chronic cyclic or acyclic pelvic pain is about 60-70%. Moreover, all stages of endometriosis, including deeply infiltrating endometriosis can be found in this population. Gubbels et al. from the Department…

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The intensity of pelvic pain is higher in endometriosis patients

The intensity of pelvic pain is higher in endometriosis patients By Irem Onur

Silva  J.B. et al., researchers from Brazil, conducted a case-control study to determine the intensity of clinical pain, the average body composition, and the anthropometric markers including the body mass index, the perimeters (waist, abdomen, hip), and the percentage of…

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The more than expected prevalence of endometriosis in patients with Mullerian abnormalities

The more than expected prevalence of endometriosis in patients with Mullerian abnormalities By Bahar Yuksel

Congenital müllerian anomalies resulting in a spectrum of uterine abnormalities are caused by the abnormal embryologic fusion of the müllerian ducts to form a normal uterine cavity.  They are often unrecognized because they are usually asymptomatic. The presence of a uterine…

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Depression and anxiety levels in "in vitro fertilization" patients with endometriosis

Depression and anxiety levels in By Hale Goksever Celik

Endometriosis is a reproductive-aged and estrogen-dependent disease. The most common symptoms of this disease are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility affecting the quality of life in several aspects mainly the psychological domain. In the literature, there are many studies…

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Endometriosis-related obstetrical complications and their outcome

Endometriosis-related obstetrical complications and their outcome By Selma Oransay

Borisova et al. from the Department of Gynecology and Obstetrics of Peoples' Friendship University, Moskow, Russia, and her colleagues from the Center of Perinatal and Reproductive Medicine of University Perugia, Italy, recently published a review of the literature data about…

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Time for reassessment : Laparoscopic surgery and bowel endometriosis

Time for reassessment : Laparoscopic surgery and bowel endometriosis By Nasuhi Engin Aydin

Ferrero and associates from medical centers of Verona and Genoa, Italy, made a comprehensive review covering all aspects of the surgical approach to bowel endometriosis, published their results in "Best Practice & Research Clinical Obstetrics and Gynaecology". Bowel endometriosis is the…

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Cellular communications: Exosomes in Endometriosis

Cellular communications: Exosomes in Endometriosis By Dr. Youngran Park

Exosomes have been reported as cell-to-cell communicators, transfer many molecules such as miRNAs, RNAs, and proteins, and their alteration may cause many disease processes, including endometriosis. Considering the role of exosomes and their cargos in a cell to cell communication as important…

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Predictors of voiding dysfunction after surgery for deep endometriosis

Predictors of voiding dysfunction after surgery for deep endometriosis By Selma Oransay

While surgery for deep endometriosis provides relief and improves the quality of life in symptomatic patients for whom medical therapy has limited effect, it may also create postoperative lower urinary tract dysfunction. Moreover, postoperative voiding dysfunction could affect the quality…

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Sleep Quality, Lifestyle Factors and Endometriosis

Sleep Quality, Lifestyle Factors and Endometriosis By Hale Goksever Celik

Endometriosis does not only affect the patients by dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. An important issue in these patients, like other chronic diseases, is sleep quality. Youseflu et al., from Iran, published a study entitled “Effects of endometriosis…

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Colorectal Deep Endometriosis Resection and Potential Complications

Colorectal Deep Endometriosis Resection and Potential Complications By Murat Osman

A severe clinical form of endometriosis, deeply infiltrating endometriosis (DIE) is characterized by more aggressive endometriotic lesions commonly involving deeper pelvic or gastrointestinal organs. It causes significant quality of life impairment and morbidity and is increasingly associated with infertility. When…

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Factors affecting the quality of life of women with endometriosis

Factors affecting the quality of life of women with endometriosis By Timur Seckin

Results from a new study suggest that the quality of life of women with endometriosis is significantly affected by their confidence to manage pain and their belief in the evolution of their condition. In this study, led by Rees M. et…

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Deep Endometriosis or Recto-uterine Obliteration Without Endometrioma

Deep Endometriosis or Recto-uterine Obliteration Without Endometrioma By Selma Oransay

The diagnostic help of ultrasound is increasing by its ability to diagnose deep infiltrating and rectouterine pouch obliteration in patients who are suffering from chronic pelvic pain. Clinicians are used to evaluating the rectal and parametrial areas of the endometriotic…

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Antioxidant Enzymes in Endometriosis

Antioxidant Enzymes in Endometriosis By Dr. Youngran Park

Recent attention has been focused on the effect of oxidative stress in the development of endometriosis. Especially, there are several studies regarding glutathione peroxidase (GPX), a major enzyme in removing various reactive oxygen species. In the field of infertility, the…

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The advantages of combined vaginal-laparoscopic approach on voiding dysfunction for rectovaginal endometriosis

The advantages of combined vaginal-laparoscopic approach on voiding dysfunction for rectovaginal endometriosis By Irem Onur

The patients with rectovaginal endometriotic nodules with extensive vaginal infiltration who are managed combined vaginal-laparoscopic approach have a lower risk of postoperative bladder dysfunction when compared to surgery via laparoscopy alone. This is according to a manuscript published in the…

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Inhibiting killer on the move

Inhibiting killer on the move By Yu Yu

The three main forms of endometriosis are superficial, ovarian, and deep endometriosis. The latter is defined by the presence of endometriotic nodules that are deeper than 5 mm. Deep endometriosis is considered the most aggressive and is associated with severe…

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Endometrial polyps of patients with and without endometriosis

Endometrial polyps of patients with and without endometriosis By Nasuhi Engin Aydin

Endometrial polyps are benign local overgrowths comprising both glands and the stroma, and are quite common in gynecological practice. Endometriosis patients also commonly have polyps, which have yielded different features than those from patients without endometriosis.  Dr. Jiangand and associates…

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The impact of laser vaporization on reproductive outcomes in women with endometrioma

The impact of laser vaporization on reproductive outcomes in women with endometrioma By Hale Goksever Celik

Despite extensive research, the optimal method for the management of endometriosis still remains unclear. Excisional surgery is claimed with a more favorable outcome than drainage and ablation regarding the recurrence of disease and symptoms. On the other hand, cyst vaporization…

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A Call for Pan-Canadian Collaboration for the Care and Quality of Life of Endometriosis Patients

A Call for Pan-Canadian Collaboration for the Care and Quality of Life of Endometriosis Patients By Timur Seckin

Wahl KJ et al., from Canada, drew attention to the lack of health care for endometriosis patients who are estimated to be 1 million in number in Canada in their recent brief communication report. The delay in the diagnosis, the…

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Bowel surgery for endometriosis

Bowel surgery for endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. The disease harbors various complications. Deep endometriosis involving the bowel is only one aspect of the condition that has variable phenotypic presentations and pathologic subtypes. Knowledge of the short- and long-term risks of the surgical…

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Benefits of Nerve-Sparing Hysterectomy

Benefits of Nerve-Sparing Hysterectomy By Selma Oransay

The retroperitoneal spread of endometriosis or cancer may involve pelvic autonomic nerves situated on the lateral aspects of uterosacral ligaments, vesicouterine ligaments, and medial aspects of parametria. During the conventional open hysterectomy operations, nerve-sparing excision is very difficult, simply because pelvic autonomic nerves…

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Mental stress promotes mice endometriosis

Mental stress promotes mice endometriosis By Bahar Yuksel

Endometriosis is a disease for which pathogenesis and progression are not fully understood. Inflammation is one of the key candidates that might be related to the creation or progression of endometriosis. In the study conducted by Kawakita et al from…

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Diagnosis and treatment of endometriosis in adolescents

Diagnosis and treatment of endometriosis in adolescents By Irem Onur

The belief that dysmenorrhea, the primary symptom of endometriosis, in adolescents is an inevitable condition seen in menstruation as well as unwillingness to perform diagnostic laparoscopy may cause the delay of diagnosis of endometriosis. This is according to a recent…

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Natural history of spontaneous endometriosis in crab-eating monkeys

Natural history of spontaneous endometriosis in crab-eating monkeys By Nasuhi Engin Aydin

Kaori Hayashi and associates from Shiga University of Medical Science, Japan, published their observations on spontaneously occurring endometriosis in crab-eating monkeys in "Tohoku Journal of Experimental Medicine"https://www.jstage.jst.go.jp/article/tjem/251/4/251_241/_pdf/-char/en. The presence of endometrial tissue outside the uterus, i.e., endometriosis is a progressive prevalent…

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Is there a commonality between endometriosis and systemic lupus?

Is there a commonality between endometriosis and systemic lupus? By Murat Osman

Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect many organs including the skin, joints, the central nervous system, and the kidneys. Women of childbearing age and certain racial groups are at increased risk to develop the condition.…

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Patient-centered care in patients with endometriosis

Patient-centered care in patients with endometriosis By Hale Goksever Celik

The women with endometriosis suffer from several symptoms and signs including dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility which have a detrimental effect on their quality of life. Endometriosis is diagnosed with 7-10 years of delay due to the absence…

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Immune cells and endometriosis pain

Immune cells and endometriosis pain By Dr. Youngran Park

Endometriosis is an estrogen-dependent inflammatory disorder in women. This disease leads to dysmenorrhea, pelvic pain, and infertility. The immune reaction is one of the most widely accepted pathologies of endometriosis. Estrogen dysfunction stimulates immune cells in the peritoneal cavity affecting…

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Voiding Dysfunction after Colorectal Surgery for Endometriosis

Voiding Dysfunction after Colorectal Surgery for Endometriosis By Timur Seckin

Postoperative voiding dysfunction is a less frequent complication of rectal shaving than that of discoid excision or segmental resection in patients undergoing colorectal surgery for endometriosis, regardless of its definition. This is according to a meta-analysis conducted by researchers from…

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Prevalence, Risk factors and Management of Bowel Fistula after Rectosigmoid Surgery for Deep Endometriosis

Prevalence, Risk factors and Management of Bowel Fistula after Rectosigmoid Surgery for Deep Endometriosis By Selma Oransay

Bowel fistula is a severe complication after the colorectal endometriosis surgery, but little is known about its prevalence, and reports on large series are lacking. To discuss specific management on colorectal deep endometriosis, Roman et al. conducted a retrospective study…

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Endometriosis prevalence among adolescents with pelvic pain

Endometriosis prevalence among adolescents with pelvic pain By Irem Onur

An updated review conducted by the investigators at EGA Institute for Women's Health, University College London, United Kingdom, in collaboration with Birmingham Women’s and Children’s Foundation Trust of the Institute of Metabolism and Systems Research at the University of Birmingham…

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Reproductive capacity and recurrence rate after surgery for Stage III/IV endometriosis 

Reproductive capacity and recurrence rate after surgery for Stage III/IV endometriosis  By Bahar Yuksel

If gaining fertility back is the main goal, the surgical removal of endometriosis lesions is globally recognized as first-line therapy. Even though, pre- and postoperative hormone therapy leads to a significant decrease in the spread of the disease measured with the…

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The effects of nutrients on endometriosis-related symptoms

The effects of nutrients on endometriosis-related symptoms By Nasuhi Engin Aydin

A recent literature review from the Netherlands by researchers Emma Huijs and Annamiek Nap, published in "Reproductive Biomedicine Online" puts light on the effects of some nutrients for endometriosis-related symptomatology.  Endometriosis has heterogeneous pathogenesis involving genetic, immunological, environmental, and hormonal…

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Early maternal separation and endometriosis progression in adult mice

Early maternal separation and endometriosis progression in adult mice By Hale Goksever Celik

The quality of life in the women affected by endometriosis depends on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Although several studies have been performed to investigate the underlying pathophysiologic mechanism, it…

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Increased expression of epithelial cell adhesion molecule and its possible role in epithelial-mesenchymal transition in endometriosis.

Increased expression of epithelial cell adhesion molecule and its possible role in epithelial-mesenchymal transition in endometriosis. By Dr. Youngran Park

Endometriosis is an estrogen-dependent disease that functional endometrial tissue exists outside both the uterine cavity and myometrium. The pathogenesis of endometriosis remains unclear and controversial. According to the implantation theory, which is the most well-known, migration and invasion are two…

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Fallopian tubes and endometriosis

Fallopian tubes and endometriosis By Selma Oransay

There are multiple theories to explain the pathogenesis of endometriosis, among which the most popular one is Sampson's retrograde menstruation theory. The role of endometrial stem cells/progenitors are widely studied to support the origin of ectopic lesions in recent decades.…

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Hormone Control Related Genes in Women With Endometriosis

Hormone Control Related Genes in Women With Endometriosis By Ellen Tumimbang

Endometriosis is an estrogen-dependent disease.  The development of endometriosis is stimulated by the specific ability to receive the estrogen that is needed for growth and differentiation of endometrial cells and has numerous biological functions in eutopic and ectopic endometrium. Estrogen…

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Endometriosis Impacts Transgender Adolescents

Endometriosis Impacts Transgender Adolescents By Irem Onur

Shim J.Y. et al, from Boston, Massachusetts retrospectively searched the electronic medical records of transmasculine patients younger than 26 years old who were diagnosed with dysmenorrhea and treated at Boston Children’s Hospital, between January 1, 2000, and March 1, 2020.…

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Clinical characteristics linked to recurrence of ovarian endometrioma

Clinical characteristics linked to recurrence of ovarian endometrioma By Nadire Duru

Endometriosis affects 10-15% of women. Three types of endometriosis are peritoneal, ovarian, and deep infiltrating endometriosis. Ovarian endometriosis is the most common type of endometriosis with a high rate of recurrence. Laparoscopy is the gold standard treatment for endometriosis and…

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The impact of obesity on safety and feasibility of laparoscopic endometriosis surgery

The impact of obesity on safety and feasibility of laparoscopic endometriosis surgery By Hale Goksever Celik

The quality of life in the women affected by endometriosis depends on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. The most common locations of endometriosis are ovary, ovarian fossa, uterosacral ligament, and…

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Adolescent endometriosis

Adolescent endometriosis By Timur Seckin

A recent article, led by experts from Peking Medical Union College, describes the clinical characteristics and postoperative symptoms of adolescent endometriosis. The authors inform that their report, which is published in the "Journal of Pediatric and Adolescent Gynecology", can provide…

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Suggested remedies for endometriosis patients during coronavirus pandemic

Suggested remedies for endometriosis patients during coronavirus pandemic By Nasuhi Engin Aydin

The pandemic of COVID-19 continues to have important effects on endometriosis patients worldwide. Many health care facilities stopped providing surgical management and outpatient appointments are canceled or postponed. Dr. Leonardi from Australia and associates from several countries published their proposals…

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Hysterectomy as a choise of chronic pelvic pain relief in endometriotic women.

Hysterectomy as a choise of chronic pelvic pain relief in endometriotic women. By Selma Oransay

Sandstrom et al. from the Department of Obstetrics and Gynecology of Umea University, Sweden, found a significant and long-lasting reduction in pain symptoms after hysterectomy among women with confirmed endometriosis and recently published their results in "BJOG". The authors performed…

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Occult microscopic endometriosis in clinically negative peritoneum

Occult microscopic endometriosis in clinically negative peritoneum By Irem Onur

Occult microscopic endometriosis may be present in approximately 39% of patients with clinically negative appearing peritoneum undergoing laparoscopy for chronic pelvic pain. This finding is presented in a study published online this month in the International Journal of Gynecology &…

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Adolescent dysmenorrhea diagnosis and management

Adolescent dysmenorrhea diagnosis and management By Hale Goksever Celik

Endometriosis is usually diagnosed in reproductive-aged women. However, recent literature proved that clinical symptoms of endometriosis are also seen the adolescent girls and young women. Dysmenorrhea, the most common gynecologic complaint among this age group, can develop due to endometriosis.…

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Bone morphogenetic protein and endometriosis

Bone morphogenetic protein  and endometriosis By Nadire Duru

Endometriosis is a chronic disease characterized by the presence of endometrial glands and stroma outside the uterus, associated with several discomforts such as pelvic pain, menstrual disorders, and infertility. Although endometriosis is categorized as a benign lesion, the ectopic endometrial…

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Local inflammation and follicle development in women with ovarian endometriosis

Local inflammation and follicle development in women with ovarian endometriosis By Dr. Youngran Park

Endometriosis, a cause of subfertility, is found in almost 50% of infertile women. The elevated levels of cytokines in the follicular fluid of patients with endometriosis might account for the ovulatory dysfunction. Granulosa cells (GCs) play important roles in follicular…

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Anogenital distance and endometriosis

Anogenital distance and endometriosis By Timur Seckin

Endometriosis may be associated with exposure of the embryo to chemicals called ‘endocrine disruptors’. Exposure to endocrine disruptors can be estimated by measuring the anogenital distance (i.e. the distance between the clitoris and the anus), using a centimeter ruler with…

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International experts commentary for assisted fertility treatment facilities amidst COVID-19

International experts commentary for assisted fertility treatment facilities amidst COVID-19 By Nasuhi Engin Aydin

A multinational and multi-institutional commentary led by Dr. Alviggi from Italy and Dr.Esteves from Brazil has addressed important issues on assisted reproductive technology treatment amid COVID-19 lockdown suggesting remedies in the journal of "Reproductive Biology and Endocrinology" May 2020 issue.…

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The effect of endometriosis on the quality of life

The effect of endometriosis on the quality of life By Hale Goksever Celik

Endometriosis, the disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity, can be diagnosed in the reproductive-aged women with an incidence of 7-15%. However, endometriosis is observed in women with chronic pelvic pain syndrome…

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Endometriosis Diagnosis in White, Black, and Asian Women

Endometriosis Diagnosis in White, Black, and Asian Women By Özge Özkaya

In a commentary published in the "International Journal of Obstetrics and Gynaecology", Drs. Farland and Horne talk about a study by researchers in Canada and the Philippines, which found that black women are less likely, and Asian women are more likely to…

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Diagnosing Deep Endometriosis Using Transvaginal Elastosonography

Diagnosing Deep Endometriosis Using Transvaginal Elastosonography By Murat Osman

Deeply infiltrating endometriosis (DIE) is an advanced form of endometriosis that causes significant morbidity to a large number of women. Early detection of endometriosis is imperative for early treatment and improved outcomes for these patients. Currently, transvaginal ultrasound (TVUS) and magnetic…

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Menstrual Blood Proteins for Endometriosis Diagnosis

Menstrual Blood Proteins for Endometriosis Diagnosis By Ellen Tumimbang

Endometriosis is a gynecological disorder characterized by endometrial tissue outside the uterine cavity. The backflow of menstrual blood from the uterus through the fallopian tubes is thought to be the cause of endometrial tissue growing outside the uterine cavity when…

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A hope for postoperative symptomatic endometriosis therapy

A hope for postoperative symptomatic endometriosis therapy By Irem Onur

A new chapter in the treatment of symptomatic endometriosis patients may begin since new medical approaches including oral GnRH antagonists, selective progesterone receptor modulators, aromatase inhibitors, and peritoneal immune response modulators are being actively evaluated. To date, there was only…

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Opioids use in women with endometriosis, what does it tell us?

Opioids use in women with endometriosis, what does it tell us? By Yu Yu

Endometriosis is a debilitating disease that can cause many painful symptoms such as dysmenorrhea, dyspareunia, infertility, chronic pelvic pain, abdominal pain, and sacral or low back pain. More than half of women diagnosed with endometriosis suffer from chronic pelvic pain.…

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Diagnosis and treatment algorithm for endometriosis

Diagnosis and treatment algorithm for endometriosis By Selma Oransay

Endometriosis is a chronic and progressive disease that affects 25-30% of women between 25-35years, clinicians commonly experience during their gynecologic practice. However, the diagnosis is still late or sometimes incorrect, and this creates severe health problems and worse outcomes. A…

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Endometriosis by Race

Endometriosis by Race By Hale Goksever Celik

Endometriosis is usually diagnosed in reproductive-aged women with an incidence of approximately 10%. The most common presenting symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility in patients with endometriosis. Some risk factors have been identified for the development of…

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Health inequalities in USA

Health inequalities in USA By Timur Seckin

Dr. E. Albert Reece, the vice president for medical affairs at the University of Maryland, Baltimore, specialized in maternal and fetal medicine, wrote on health disparities in the American nation, in Obstetrics and Gynecology News, on the website www.mdedge.com, in June…

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Discrepancies between racial/ethnic groups and choice of hysterectomy procedures

Discrepancies between racial/ethnic groups and choice of hysterectomy procedures By Nasuhi Engin Aydin

Dr. Pollack and associates from Washington University, St.Louis, made multistate research regarding the patient profile in hysterectomies and published their results in the 2019 December issue of "The Journal of Minimally Invasive Gynecology". The most frequently performed nonobstetric surgery in…

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Is oocyte cryopreservation useful for fertility preservation in ovarian endometriosis?

Is oocyte cryopreservation useful for fertility preservation in ovarian endometriosis? By Irem Onur

Women with endometriosis tend to have lower fecundity compared to normal couples. Furthermore,  endometrioma itself may reduce the ovarian reserve by altering ovarian physiology in the surrounding healthy ovarian tissue. The treatment for endometrioma is surgical removal in most cases, however,…

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How Can Racial and Ethnic Disparities Be Reduced Among Women’s Health and Healthcare?

How Can Racial and Ethnic Disparities  Be Reduced Among Women’s Health and Healthcare? By Özge Özkaya

The American College of Obstetricians and Gynecologists published a set of recommendations to help reduce racial and ethnic disparities in women’s health and healthcare and encourage obstetricians, gynecologists, and other health care practitioners to engage in activities to help achieve…

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Endometriosis surgery and future pregnancy complications

Endometriosis surgery and future pregnancy complications By Selma Oransay

Endometriosis is one of the known diseases for infertility in the reproductive period of women. Several studies revealed that endometriosis itself maybe the reason for some unfavorable obstetric outcomes. Localization, the type of endometriotic lesions, and the stage of endometriosis…

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Case-control study to develop a questionnaire for early diagnosis of endometriosis

Case-control study to develop a questionnaire for early diagnosis of endometriosis By Nadire Duru

Endometriosis, which affects 5–10% of women of reproductive age, is a chronic gynecological disease characterized by the presence of endometrial glands and stroma outside the uterus, associated with several discomforts such as pelvic pain, menstrual disorders, and infertility. Ultrasound evaluation…

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The predictors for sexual dysfunction in infertile women with endometriosis

The predictors for sexual dysfunction in infertile women with endometriosis By Hale Goksever Celik

Endometriosis is a disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. Its incidence ranges up to 10% of reproductive-aged women. The most common symptoms in these women are chronic pelvic pain, dyspareunia, and…

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Immune System, Cytokines and Endometriosis

Immune System, Cytokines and Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent chronic disease. Diagnosing endometriosis is difficult because the signs and symptoms vary considerably. Therefore, the discovery of a reliable non-invasive diagnostic biomarker would represent a major advance for the clinical diagnosis of endometriosis.  It has been…

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Neglected needs of endometriosis and infertility patients during COVID-19 pandemic

Neglected needs of endometriosis and infertility patients during COVID-19 pandemic By Timur Seckin

With the global outbreak of the COVID-19, hospitals canceled surgeries and people are afraid of going to hospitals. However, chronic diseases still need to be managed. Rowe H. and Quinlivan J., researchers from Australia, pointed out the neglected needs of…

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Risk Factors Associated with Ureteral Endometriosis

Risk Factors Associated with Ureteral Endometriosis By Özge Özkaya

Patients with severe endometriosis, uterosacral ligament deep involvement with endometriosis lesions of  3 cm in diameter or more, and the presence of previous endometriosis surgery have a significantly higher risk of having ureteral endometriosis. This is according to a study…

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Resveratrol for infertility: A frenemy?

Resveratrol for infertility: A frenemy? By Selma Oransay

Ovarian aging is defined by an age-specific decline of the functional ovarian reserve. Female ovarian reserve declines progressively with increasing chronological age. Chronic damage by reactive oxygen species results in deterioration and aging through mitochondrial dysfunction, telomere shortening, cohesion dysfunction,…

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Fatigue from the viewpoint of patients with endometriosis

Fatigue from the viewpoint of patients with endometriosis By Irem Onur

Fatigue, feeling spoonie, is documented as a significant symptom of endometriosis in many studies. Researchers from three different institutions dealing with reproductive health conducted individual interviews with patients reporting moderate to severe endometriosis-related pain to better understand endometriosis-related fatigue and…

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Postmenopausal endometriosis: Is it a rare phenomenon?

Postmenopausal endometriosis: Is it a rare phenomenon? By Hale Goksever Celik

Endometriosis, the estrogen-dependent disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity, is generally diagnosed in the reproductive-aged women. However, recent literature proved that this disease can also be observed in the premenopausal and…

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NAT2 as potential biomarker for the diagnosis and treatment of endometriosis

NAT2 as potential biomarker for the diagnosis and treatment of endometriosis By Nadire Duru

Endometriosis affects 5–10% of women of reproductive age causing several discomforts, pelvic pain, menstrual disorders, ectopic bleeding, infertility, and sometimes even malignant transformation but its etiology remains unclear. Accumulating evidence point a key role for genetic factors and there is…

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miR-92a and progesterone resistance in endometriosis

miR-92a and progesterone resistance in endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. This incidence of this disease is 35% to 50% among those who suffer from chronic pelvic pain and infertility, which has a negative effect on the quality of life and on health. Recent genome-wide associations…

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Endometriosis and Insomnia

Endometriosis and Insomnia By Timur Seckin

There should be more awareness among clinicians for the relationship between insomnia and endometriosis, the study suggests. There needs to be a suspect of endometriosis whenever the clinician faces women of reproductive age with sleep or insomnia-related symptoms. This symptom is…

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Progressive nature of ovarian endometrioma

Progressive nature of ovarian endometrioma By Yu Yu

The effective management of endometriosis requires a proper understanding of how the condition progress as women age, especially for those women with early onset of endometriosis. Several studies have tried to characterize the evolution of endometriosis. Some of the key…

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Improved fusion imaging for the detection of Endometriosis

Improved fusion imaging for the detection of Endometriosis By Murat Osman

This paper studied a new fusion method for magnetic resonance (MR) and ultrasound (US) imaging for the appropriate diagnosis of endometriosis. The diagnosis of endometriosis in patients with a chronic pelvic disease is delayed, due to the disease, patient, and physician-led…

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Appendiceal endometriosis

Appendiceal endometriosis By Selma Oransay

Jeong et al. from the Departement of Surgery, Trinity School of Medicine, Saint Vincent, recently published their interesting appendectomy case in "Hong Kong Medical Journal". In their case, endometriosis inside the cavity of the appendix mimicked appendicitis, the patient submitted…

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Defective “ferroptosis”: a new pathogenetic explanation of endometriosis

Defective “ferroptosis”: a new pathogenetic explanation of endometriosis By Nasuhi Engin Aydin

Dr. Ng and associates from Tufts University School of Medicine, Boston, USA made a comprehensive review of the role of the iron element in the development of endometriotic lesions. Though iron element is essential for cell survival, and its deficiency is important…

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Are endometriosis patients at higher risk of bipolar disorder?

Are endometriosis patients at higher risk of bipolar disorder? By Irem Onur

Endometriosis patients are prone to develop certain psychiatric disorders, including depression and anxiety, as well as bipolar disorder, according to a nationwide population-based cohort study from Taiwan. Bipolar disorder formerly called manic-depression is a chronic mental disorder characterized by unusual changes…

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Maternal body mass index and neonatal outcomes in women with endometriosis

Maternal body mass index and neonatal outcomes in women with endometriosis By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal-like tissue outside the uterine cavity. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of…

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Interleukin-37b inhibits the growth of murine endometriosis-like lesions

Interleukin-37b inhibits the growth of murine endometriosis-like lesions By Nadire Duru

Endometriosis is a chronic gynecological disease that causes chronic pain and infertility in women. Despite continuous efforts and numerous research, there is, ultimately, still much to understand about the pathogenesis of endometriosis. Inflammatory factors including several interleukins have already been…

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Hysterolaparoscopy Plus Assisted Reproduction Improves Fertility in Women with Endometriosis

Hysterolaparoscopy Plus Assisted Reproduction Improves Fertility in Women with Endometriosis By Özge Özkaya

Hysteroscopy and laparoscopic surgery is an effective and reliable therapeutic procedure, confirmed a study published in the "Journal of Clinical Medicine". The approach is even more effective when combined with assisted reproductive techniques such as artificial insemination and in vitro…

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Steroid hormone receptors in endometriosis

Steroid hormone receptors in endometriosis By Yohan Suryo

Therapeutics that target the steroid hormones are the standard treatment for women with endometriosis because steroid hormones play an important role in endometrial physiology and pathogenesis of endometriosis. Examples of these therapeutics include anti-estrogens, estrogen receptor (ER) modulators, progestins, and…

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How should MRI images be obtained for optimal endometriosis detection?

How should MRI images be obtained for optimal endometriosis detection? By Murat Osman

It is well known that the diagnosis of endometriosis for some patients with the chronic pelvic disease is delayed, often for years, due to the disease, patient, and physician-led factors. An area of active study is how ordering physicians can…

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Transvaginal sonography for predicting the distance between rectosigmoid endometriosis and the anal verge

Transvaginal sonography for predicting the distance between rectosigmoid endometriosis and the anal verge By Timur Seckin

For optimal surgery, pre-surgical assessment of the distance between rectosigmoid deep endometriosis lesions and the anal verge (Lesion to Anal Verge Distance-LAVD) is recommended by many specialists. A group of researchers from Norway, Austria, and Australia studied the accuracy of…

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Oxidative stress leads to elevated cytokines, excessive structural damage and angiogenesis

Oxidative stress leads to elevated cytokines, excessive structural damage and angiogenesis By Yu Yu

Endometriosis is characterized by elevated intracellular reactive oxygen species, which is then believed to upregulate inflammatory cytokines. Reactive oxygen species also regulate the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which is closely linked with immune responses.…

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Surgical approach to rectovaginal endometriosis.

Surgical approach to rectovaginal endometriosis. By Selma Oransay

Recto-vaginal endometriosis incidence is estimated at 3.8%-37% among women with endometriosis and when it exists it's a part of deeply infiltrated endometriosis, thus advance stage endometriosis. Raimondo et al. from the Department of Obstetrics and Gynecology of the University of…

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tRNA-derived fragments in ovarian endometriosis?

tRNA-derived fragments in ovarian endometriosis? By Dr. Youngran Park

Endometriosis is an estrogen-dependent mysterious disorder characterized by the presence of endometrium outside the normal location of the uterus cavity. This disease affects approximately 10% of reproductive-aged women and becomes a major reason for infertility in reproductive-aged women and dysmenorrhea…

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Recurrence following surgery for subtypes of endometriosis

Recurrence following surgery for subtypes of endometriosis By Hale Goksever Celik

Endometriosis is a disease identified by the location of endometrial stromal and glandular cells outside the uterine cavity. It is considered as a gynecological disease of reproductive-aged women. Three subtypes of endometriosis are peritoneal endometriosis which defines the endometriotic lesions…

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The efficacy of combined hormonal contraception on pelvic pain in endometriosis patients

The efficacy of combined hormonal contraception on pelvic pain in endometriosis patients By Irem Onur

Chronic pelvic pain, which is experienced by more than 33% of endometriosis patients, constitutes a significant challenge for patients and physicians. A new study that appears in the journal Human Reproduction Open has explored the prevalence of endometriosis patients with a history…

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Antioxidants inhibit autophagy in ectopic endometrial cells

Antioxidants inhibit autophagy in ectopic endometrial cells By Nadire Duru

Factors involved in the development of ectopic endometrium are not well-known, but several reports demonstrate a potential role for the pathophysiological processes including autophagy. Studies show that autophagy plays a significant role in endometriosis but the key mechanisms underlying the…

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A Routine Pelvic Ultrasound Examination Should Include an Evaluation for Endometriosis

A Routine Pelvic Ultrasound Examination Should Include an Evaluation for Endometriosis By Özge Özkaya

Routine pelvic ultrasound examination should be extended beyond the uterus and ovaries into the posterior and anterior pelvic compartments, according to Australian doctors.  With such examinations, deep infiltrating endometriosis nodules can be searched, say the authors, allowing women to be…

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Fertility conservation in women with endometriosis

Fertility conservation in women with endometriosis By Selma Oransay

Endometriosis affects 10-15% of women in their reproductive period and almost half of them may need Assisted Reproductive techniques to conceive. Moreover, increased malignancy risk is threatening the women with severe endometriosis in addition to their decreased ovarian reserve. Due…

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Imaging of gastrointestinal endometriosis

Imaging of gastrointestinal endometriosis By Murat Osman

Endometriosis is a disease characterized by the ectopic implantation of endometrial tissue to surrounding pelvic and extra-pelvic structures. One frequent site of involvement is the gastrointestinal(GI) tract, which occurs especially among women with deep infiltrating endometriosis. Most cases of GI-involving…

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Fertility preservation protocols in women with endometriosis

Fertility preservation protocols in women with endometriosis By Hale Goksever Celik

Infertility is one of the major symptoms in women with endometriosis. Childbearing at a delayed age is preferred by the majority of women recently who consult for the demand for fertility preservation procedures. There are several techniques for fertility preservation…

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Urgent Need For Building Resilience

Urgent Need For Building Resilience By Timur Seckin

According to Naeem et al.’s article, “Coping with Covid”, Cognitive Behavioral Therapy (CBT) is the ideal intervention tool to increase resilience. Their study has recently been published in "Kyber Medical University Journal". The authors investigate the psychological impact of the Covid-19…

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Early Life Factors for Endometriosis

Early Life Factors for Endometriosis By Dr. Youngran Park

Endometriosis affects approximately 10% of reproductive-aged women. Despite the significant impact, the etiology of endometriosis is still unclear. A recent systematic review of 15 studies of adolescents found that overall 65% of girls undergoing laparoscopic investigation were diagnosed with endometriosis.…

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Long-term Pregnancy Results after Surgical Removal of Endometrioma

Long-term Pregnancy Results after Surgical Removal of Endometrioma By Irem Onur

Sun et al., from China, investigated the pregnancy outcomes and the related factors in patients with endometrioma and stage III-IV endometriosis along with a long-term follow-up postoperatively. Their study has recently been published in the journal named "Advances in Therapy".…

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The Relationship Between Dyspareunia and Infertility in Endometriosis

The Relationship Between Dyspareunia and Infertility in Endometriosis By Selma Oransay

Wahl et al. from the Center of Pelvic Pain and Endometriosis British Columbia Women's Hospital, Vancouver, Canada studied with endometriotic patients suffering from dyspareunia who were referred to their center and built a cross-sectional study to investigate the relations between…

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All aspects of endometriosis reviewed with focus on modern management

All aspects of endometriosis reviewed with focus on modern management By Nasuhi Engin Aydin

Dr. Chapron and associates from academic centers in France published in Nature Review Endocrinology, a comprehensive review on endometriosis. The article is inclusive of all aspects of endometriosis but especially focuses on the management of the disease with its contemporary status.  Having a…

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Abdominal wall endometriosis: Who is at risk and what causes it?

Abdominal wall endometriosis: Who is at risk and what causes it? By Murat Osman

Endometriosis is a condition that can cause anatomic, hormonal, and inflammatory disturbances that may ultimately result in decreased fertility or infertility. It is a disease process that is defined as ectopic endometrial-like tissue implanting itself to various pelvic and extra…

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Polymorphisms and endometriosis: a systematic review and meta-analyses.

Polymorphisms and endometriosis: a systematic review and meta-analyses. By Yohan Suryo

The symptoms of endometriosis are varied among women and include chronic pelvic pain, infertility, and fatigue. There are no reliable blood tests and medical imaging techniques such as MRI and ultrasound are not always satisfactory. The lack of endometriosis-specific symptoms…

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Does Getting Pregnant Really Help When You Have Endometriosis?

Does Getting Pregnant Really Help When You Have Endometriosis? By Özge Özkaya

Pregnancy has a favorable impact on the volume of deep infiltrating endometriosis lesions according to a study published in the scientific journal "PLoS One". This is the first study that demonstrates such a favorable impact of pregnancy on endometriosis lesion…

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Kisspeptin and its Receptor in the Pathogenesis of Endometriosis

Kisspeptin and its Receptor in the Pathogenesis of Endometriosis By Irem Onur

It is known that matrix metalloproteinases (MMP) may play a role in the pathogenesis of endometriosis. For example, the upregulation of MMP-2 and MMP-9 may enhance the degradation of extracellular matrix proteins, facilitating cell migration and invasion. Kisspeptin (KISS1, also…

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The predictive factors for early spontaneous miscarriage in IVF/ICSI cycles

The predictive factors for early spontaneous miscarriage in IVF/ICSI cycles By Hale Goksever Celik

The most common presenting complaints of endometriosis are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Affected women demand therapy for these symptoms of endometriosis, notably fertility problems. The clinical pregnancy rate has increased up to 60% in assisted reproductive…

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Regulation of Inflammation in Endometriosis

Regulation of Inflammation in Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent and multifaceted gynecological condition. Unfortunately, this disease frequently causes chronic and cyclic pelvic pain. Though there are several treatments are available, there is not an actual cure for this disease. Therefore, the development of new therapy…

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Diaphragmatic endometriosis

Diaphragmatic endometriosis By Selma Oransay

Diaphragmatic endometriosis is a rare clinical condition that may show signs and symptoms like chest pain, right upper quadrant abdominal pain, shoulder pain, pleuritic pain, hemothorax, pneumothorax, hemoptysis, and thoracic endometriosis syndrome while the major part of the patients is…

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Leiomyomas have similar genetic background with endometriosis

Leiomyomas have similar genetic background with endometriosis By Nasuhi Engin Aydin

This multicenter research conducted in institutions located in the USA and UK published in Nature Communications, October 2019 issue.  Leiomyomata of the uterus are hormone-dependent tumors with an estimated prevalence of about  20-77%. İn several publications. Research in uterine leiomyoma…

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Cycle-related gastrointestinal complaints in reproductive age young women

Cycle-related gastrointestinal complaints in reproductive age young women By Timur Seckin

An analysis of 1-year data on 266 patients who presented to the Clinic and Polyclinic for Gynecology and Reproductive Medicine at Jena University Hospital to undergo surgery for endometriosis and its symptoms was performed by Nicolaous K. et al., a…

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Clinical Evaluation of Endometriosis-Associated Pain

Clinical Evaluation of Endometriosis-Associated Pain By Nadire Duru

Endometriosis has a noteworthy impact on the quality of life of the patients diagnosed with it since it is associated with unpleasant conditions such as endometriosis-associated pain. The diagnosis of endometriosis is not always straightforward because of the varying symptoms…

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The relationship of serum concentrations of neuropilin-1 (NRP-1) and endometriosis

The relationship of serum concentrations of neuropilin-1 (NRP-1) and endometriosis By Irem Onur

Although many serum biomarkers or biomarker panels for endometriosis are evaluated, none of them is exact enough to be used in daily laboratory practice. In a recent study, which has been published in Scandinavian Journal Of Clinical and Laboratory Investigation, Barberic…

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The genetic mutations in uterine adenomyosis

The genetic mutations in uterine adenomyosis By Hale Goksever Celik

Adenomyosis is defined as the localization of endometrial stromal and glandular cells in the myometrium. This disease is a reproductive-aged women disease, like endometriosis. Additionally, adenomyosis is frequently observed together with endometriosis and leiomyomas due to common histological features and…

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How well do providers understand endometriosis?

How well do providers understand endometriosis? By Demet Candaş Green

Endometriosis is a challenging disease no matter what side of the equation you are in, a patient or a provider who cares for patients with the disease. It impacts millions of women worldwide, making it one of the most prevalent…

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Phytotherapy as an alternative endometriosis treatment

Phytotherapy as an alternative endometriosis treatment By Dr. Youngran Park

Endometriosis is an estrogen-dependent gynecological disease that affects 5–10% of women in fertile age. Different therapeutic strategies are available to treat this disease, such as surgery, hormonal therapies, and nonsteroidal anti-inflammatory drugs.  Medical therapy usually consists of different hormonal drugs,…

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Adiposity, endometriosis type and severity

Adiposity, endometriosis type and severity By Selma Oransay

Dr. Jiyoung from the division of Public Health, Department of Family and Preventive Medicine of the University of Utah, planned a prospective cross-sectional study to assess whether there is an inverse relationship between the adiposity and endometriosis. The results of…

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The role of microbiota in the etiopathogenesis of endometriosis

The role of microbiota in the etiopathogenesis of endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. Although many advanced types of research about the etiology, differential diagnosis and treatment have been performed, it still remains an enigmatic disease. Dr. Bedaiwy, a scientist and physician…

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Integrated bioinformatic analysis for endometriosis diagnosis

Integrated bioinformatic analysis for endometriosis diagnosis By Nadire Duru

Endometriosis is considered as a non-malignant disease, but it is associated with several unfavorable conditions including non‑menstrual pelvic pain and infertility. Surgical resection and hormone suppression are common means of treatments; however, several side-effects and the recurrence are not preventable.…

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Preoperative serum CA 125 levels predict the severity of adhesions in endometriosis

Preoperative serum CA 125 levels predict the severity of adhesions in endometriosis By Irem Onur

Lee Y. et al., a group of researchers from Korea evaluated the correlation between preoperative serum markers and pelvic adhesions in endometriosis patients and explored the markers’ clinical value for outcome prediction. They have recently published their study in the…

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Which treatment option improves fertility the most?

Which treatment option improves fertility the most? By Murat Osman

Endometriosis is a condition that causes anatomic, hormonal, and inflammatory disturbances that may ultimately result in decreased fertility or infertility. It is estimated that 30-50% of women with endometriosis suffer from infertility. Thus, the role of surgical, medical, or expectant…

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Treatment choices for abdominal wall endometriosis

Treatment choices for abdominal wall endometriosis By Selma Oransay

Welch et.al, from the Department of  Radiology, Mayo Clinic, Rochester, worked with his gynecologist colleagues to underline the current treatment algorithm of abdominal wall endometriosis in Mayo Clinic. Their experience results recently published in the journal "Abdominal Radiology". Abdominal wall…

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The role of acidic ribosomal protein P1 in Endometriosis

The role of acidic ribosomal protein P1 in Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. The disease develops and composed of the ectopic endometrial-like tissue which establishes primarily in the pelvic cavity. Previous findings clearly show that estrogen-related factors are critical for endometriosis development and progression. However, we do have…

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Woman at reproductive age suffering from migraines should consider getting evaluated for endometriosis.

Woman at reproductive age suffering from migraines should consider getting evaluated for endometriosis. By Demet Candaş Green

What do migraine and endometriosis have in common? One can easily answer “pain”. Turns out there are other shared aspects when it comes to these two conditions: both have a high prevalence in women of childbearing age, both suffer from…

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Rare lesions in the pathologic examinations of endometriosis.

Rare lesions in the pathologic examinations of endometriosis. By Selma Oransay

Dr. Glenn McCluggage from the Department of Pathology, Belfast Health, and Social Care Trust, penned a review about selected uncommon variants of endometriosis or benign alterations that may cause difficulties of pathologic diagnosis and provided all related histopathological illustrations in…

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A review of endometriosis in adolescent girls and young women

A review of endometriosis in adolescent girls and young women By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease which is commonly diagnosed in reproductive-aged women. On the other hand, this disease can develop earlier in life due to different etiopathogenetic mechanisms. Especially adolescents who experienced neonatal uterine bleeding are under the risk for…

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Role of miR-141 in endometriosis

Role of miR-141 in endometriosis By Nadire Duru

MicroRNAs (miRNAs) are short (18–24 nucleotides) endogenous non-coding RNAs that regulate a broad range of signaling pathways. They bind to specific sequences resulting in mRNA degradation and protein inhibition. Deregulation of miRNAs is associated with the development of many disease…

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Impact of Genetic Variations in Endometriosis

Impact of Genetic Variations in Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. This disease affects approximately 7% to 10% of reproductive-aged women and causes negative impacts on society. The underlying causes are unclear; therefore, the understanding of this disease remains a major clinical challenge. Endometriosis has a…

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The prevalence and severity of endometriosis today

The prevalence and severity of endometriosis today By Irem Onur

Ghiasi M. et al., a group of researchers from the USA, presented a comprehensive review of the prevalence, incidence, and stage of endometriosis worldwide as reported over the past 30 years. Researchers performed a search in four databases, including PubMed,…

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Worrying signs of Endometriosis on Hysterosalpingography

Worrying signs of Endometriosis on Hysterosalpingography By Murat Osman

Hysterosalpingography (HSG) is an imaging modality that utilizes fluoroscopy in order to evaluate the uterine cavity, fallopian tubes, and adjacent peritoneal cavity by injecting contrast media through the cervical canal. It is an important tool in the work-up of patients who…

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Endometriosis Severity and Complication Risks Following Laparoscopic Surgery

Endometriosis Severity and Complication Risks Following Laparoscopic Surgery By Özge Özkaya

In a research article published in the journal Acta Obstetricia et Gynecologica Scandinavica, researchers at Brigham and Women's Hospital in Boston, Massachusetts suggested that the severity of endometriosis could not be a predictor of the risk of post-operative complications. In…

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The association between endometriosis and ectopic pregnancy

The association between endometriosis and ectopic pregnancy By Hale Goksever Celik

Endometriosis is a chronic inflammatory disease with a broad spectrum of symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain and fertility problems. It has been understood in the light of scientific evidence that endometriosis is also associated with other poor…

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What we should know in managing infertility related to endometriosis?

What we should know in managing infertility related to endometriosis? By Nasuhi Engin Aydin

Dr. Llarena and associates made a comprehensive review of the causes of infertility in endometriosis and adverse effects of surgical procedures in Clinical Medicine Insights: Reproductive Health. Infertility is an important issue in endometriosis patients and about 30-50 % face infertility.…

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Endometriosis and atherosclerotic cardiovascular disease

Endometriosis and atherosclerotic cardiovascular disease By Selma Oransay

Endometriosis and atherosclerotic cardiovascular disease show the same pathologic mechanism in terms of endothelial dysfunction. Tan et al. from the Department of Obstetrics and Gynecology, the University of British Columbia, Vancouver, Canada reviewed the literature aiming to determine whether women…

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CXCR4 or CXCR7 antagonists as novel therapies for endometriosis

CXCR4 or CXCR7 antagonists as novel therapies for endometriosis By Dr. Youngran Park

Endometriosis is a common, estrogen-dependent chronic inflammatory disorder. It affects approximately 5-10% of reproductive-aged women and 20-50% of infertile women. Endometriosis also has a significant social and psychological impact on the lives of women. Despite such a significant burden, there…

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A nonhormonal treatment of endometriosis: Dichloroacetate

A nonhormonal treatment of endometriosis: Dichloroacetate By Irem Onur

In women with endometriosis, peritoneal mesothelial cells show higher glycolysis, lower mitochondrial respiration, decreased enzymatic activity of pyruvate dehydrogenase and increased production of lactate compared to women without the disease. Transforming growth factorβ1 and lactate are elevated in the peritoneal…

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What do Women with Endometriosis Think About the Medical Profession?

What do Women with Endometriosis Think About the Medical Profession? By Özge Özkaya

Failure of surgical treatment, use of the emergency room, and access to complementary healthcare are factors associated with a negative perception of the medical profession in women with endometriosis.  This is according to a study conducted by researchers in British…

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A comprehensive review on the etiopathogenesis of endometriosis

A comprehensive review on the etiopathogenesis of endometriosis By Nasuhi Engin Aydin

Endometriosis, being a heterogeneous disease has a highly complex etiopathogenesis.  A multicenter comprehensive review on this important subject from Italy, Germany, and the USA by Lagana and associates, was recently published in the "International Journal of Molecular Sciences" an open-access journal. Computerized…

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Endometriosis and ovarian reserve

Endometriosis and ovarian reserve By Hale Goksever Celik

Endometriosis is most frequently encountered in reproductive-aged women. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of 25-40%. Although the exact mechanism explaining the association between…

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How to design patient-centered interventions to meet the needs of endometriosis patients

How to design patient-centered interventions to meet the needs of endometriosis patients By Selma Oransay

The treatment of endometriosis is not perfect and necessitates the development of patient-oriented care initiatives. On this basis, patient-related transparent information should be the priority for researchers to find out a way for targeted interventions. Steele et al. from Australia and…

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The Molecular Profile Unique to Endometriosis

The Molecular Profile Unique to Endometriosis By Murat Osman

Endometriosis remains to be a disease entity that is not fully understood. However, recent studies suggest that endometriosis is characterized by several dysregulated biochemical pathways that allow for its survival and growth outside the uterine endometrium. Authors have recently published…

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When to do - and when not to do surgery for endometriosis

When to do - and when not to do surgery for endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. It was estimated to affect about 176 million women in the world and usually causes pelvic pain and infertility. Unfortunately, the current understanding of this disease is very limited. Though there are many remaining questions,…

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Endometriosis in the Urinary Bladder

Endometriosis in the Urinary Bladder By Timur Seckin

A case of bladder endometriosis is reported by Geng JH, from Taiwan, and the paper has been recently published in The New England Journal Of Medicine. The patient was a 38-year-old woman presented to the outpatient urology clinic with complaints…

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Does the Severity of Endometriosis Increase the Risk of Complications Following Surgery?

Does the Severity of Endometriosis Increase the Risk of Complications Following Surgery? By Özge Özkaya

The severity of endometriosis cannot predict the risk of complications after laparoscopy. Instead, the complexity of the surgical procedure itself may increase the risk of complications. This is according to a study published in the journal "Acta Obstetricia et Gynecologica Scandinavica".…

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A new ultrasound subgrouping reveals good clinical correlations in adenomyosis

A new ultrasound subgrouping reveals good clinical correlations in adenomyosis By Nasuhi Engin Aydin

Exacoustos and colleagues from two endometriosis tertiary referral centers in Rome, Italy published their observational, prospective study of the recently proposed transvaginal ultrasonographic scoring system in the "Journal of Minimally Invasive Gynecology". Adenomyosis or “endometriosis interna” is defined as the…

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Recent advances in the diagnosis and treatment of endometriosis

Recent advances in the diagnosis and treatment of endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. The most common complaints of women with endometriosis are pain and fertility problems. Although many advanced types of research about the etiology, differential diagnosis and treatment have been…

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Surgery and the endometriosis associated-pain: A systematic review

Surgery and the endometriosis associated-pain: A systematic review By Selma Oransay

The surgical approach for pelvic pain-related to endometriosis depends on the stage and the type of the endometriotic lesion and ranging from ablation and the excision of the lesions to radical surgery as hysterectomy with removal of ovaries and presacral…

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The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis

The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis By Dr. Youngran Park

Endometriosis is a very common gynecological disorder affecting approximately 10% of reproductive-aged women, and it is known by the abnormal growth of endometrial stroma and glands outside the uterus. Though the pathogenesis of endometriosis is not clearly understood so far,…

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Post-menopausal women diagnosed with Endometriosis and "Imaging"

Post-menopausal women diagnosed with Endometriosis and By Murat Osman

Postmenopausal endometriosis is an underrecognized clinical entity that may present similarly to those of younger patients with endometriosis. Radiologists have an important role in the diagnosis of these patients as they recommend which imaging study should be used to differentiate…

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Medical databases yield 32 published cases of surgically treated liver endometriosis

Medical databases yield 32 published cases of surgically treated liver endometriosis By Nasuhi Engin Aydin

Prodromidou and colleagues from Greece have published a review of surgically diagnosed, histopathologically proven liver endometriosis cases published worldwide, in the journal "Annals of Hepatology". Searching at three electronic medical databases namely, PubMed (1966–2019), Scopus(2004–2019), and Google Scholar (2004–2019) for…

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Hemorrhagic Ascites, Belly-Blood: The cause may be endometriosis!

Hemorrhagic Ascites, Belly-Blood: The cause may be endometriosis! By Timur Seckin

A paper on the presentation of hemorrhagic ascites in endometriosis patients, written by Bernard et al. from the United States and China, was published in the journal Fertility and Sterility. From 1978 to 2016, the authors found only 37 articles, which describe 42…

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Circulating Endometrial Cells

Circulating Endometrial Cells By Yu Yu

Endometriosis is difficult to diagnose because of non-specific symptoms. Currently, there is no biomarker that allows for non-invasive diagnosis of the condition.  Surgical laparoscopy remains the standard for diagnosis. Circulating endometrial cells (CECs) is the lymphovascular spread of endometrial cells.…

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MRI findings predicting the need for colorectal surgical treatment of deep infiltrating endometriosis

MRI findings predicting the need for colorectal surgical treatment of deep infiltrating endometriosis By Irem Onur

LAY SUMMARY: Brusic A. et al., a group of researchers from Australia, conducted a retrospective study to identify the features of deep infiltrating endometriosis on MRI which have an association with colorectal surgical bowel resection. They have recently published their…

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Is deep infiltrating rectosigmoid endometriosis a progressive disease?

Is deep infiltrating rectosigmoid endometriosis a progressive disease? By Demet Candaş Green

This study by Netter at al., published in "Human Reproduction" in November 2019 aimed to assess the risk of progression of deep endometriotic nodules infiltrating the rectosigmoid and to evaluate the influence of continuous amenorrhoea (absence of menstruation) on the development…

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Regret assessment in women under 35 years who underwent hysterectomy

Regret assessment in women under 35 years who underwent hysterectomy By Hale Goksever Celik

Hysterectomy is the most common gynecological operation in women for the management of benign or malign indications. Leiomyomas, menorrhagia, endometriosis, and pain unresponsive to medical treatment can be accepted as the most common indications for hysterectomy. However, hysterectomy, as the…

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Endometriosis features vs Patient age

Endometriosis features vs Patient age By Dr. Youngran Park

Endometriosis, a common gynecological disease, has significant negative impacts on patients’ daily life. Especially in younger women who have yet to achieve pregnancy, effective management should consider the disease progression. Though it is still under debate, some people suggest that…

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Cannabis usage among Australian women with endometriosis

Cannabis usage among Australian women with endometriosis By Irem Onur

Sinclair J. et al., a group of researchers from Australia, conducted a cross-sectional online survey to determine the prevalence, tolerability, and self-reported effectiveness of cannabis in women with endometriosis. This study included 484 women with complete responses. Of all women,…

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Cloverleaf Sign: A new MRI sign for diagnosing DIE

Cloverleaf Sign: A new MRI sign for diagnosing DIE By Selma Oransay

Magnetic resonance imaging provides accurate information for the staging of deeply infiltrating endometriosis, especially when the patient is virgin, obese or has limited transvaginal examinations due to pelvic pain. In this recently published study in Investive Radiology, Harma et al.…

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How Best to Assess Productivity at Work Among Women with Endometriosis?

How Best to Assess Productivity at Work Among Women with Endometriosis? By Özge Özkaya

The health-related productivity questionnaire (HRPQ) is a valid tool to evaluate patient-reported productivity at work and at home among women with endometriosis found a study by U.S. researchers.  This finding is important because it shows that HRPQ can be used…

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Recurrent endometriosis is a real challenge both for the patients and clinicians

Recurrent endometriosis is a real challenge both for the patients and clinicians By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Current medical and surgical treatment options have several limitations including the side effects, costs, risk of recurrence, effects on conception capability. Recurrence is a…

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Endometriosis and Insulin dependent Diabetes Mellitus

Endometriosis and Insulin dependent Diabetes Mellitus By Nasuhi Engin Aydin

Simmen and associates from the University of Arkansas for Medical Sciences, Alabama, published a review article about the co-existence of type 1 diabetes mellitus (T1DM)  and endometriosis, in the recent issue of the "Journal of Endocrinology". Insulin-dependent diabetes or T1DM…

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A new target for the treatment of endometriosis?

A new target for the treatment of endometriosis? By Dr. Youngran Park

Endometriosis affects around 10% of women in reproductive age, estimating more than 176 million women worldwide. Inflammation in the pelvic cavity is very common in endometriosis patients. Therefore, there are high concentrations of cytokines and immune cells in the peritoneal…

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Factors affecting risk of ovarian endometriosis malignancy

Factors affecting risk of ovarian endometriosis malignancy By Özge Özkaya

Getting married when older, having had ovarian endometriosis for longer, giving birth in a shorter time, and other complications in the uterus that are benign may all increase the risk of ovarian endometriosis malignancy. This is according to a study…

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The effect of endometriosis on implantation in women with endometriosis associated infertility

The effect of endometriosis on implantation in women with endometriosis associated infertility By Hale Goksever Celik

One of the most common clinical findings of women with endometriosis is fertility problems. Women with endometriosis often benefit from in vitro fertilization methods to get pregnant. However, whether there is a detrimental effect of endometriosis on in vitro fertilization outcomes…

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A rigorous literature review on endometriosis

A rigorous literature review on endometriosis By Irem Onur

Bulun SE. et al., from Feinberg School of Medicine, Northwestern University, Chicago, conducted a rigorous literature review on endometriosis. This outstanding review by Dr. Bulun et al. addresses the definition, remarkable medical features, clinically useful research findings, prevalence and distribution,…

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Thoracic endometriosis: the most frequent endometriosis involvement outside abdominopelvic cavity

Thoracic endometriosis: the most frequent endometriosis involvement outside abdominopelvic cavity By Nasuhi Engin Aydin

Six to ten percent of reproductive-age women are affected by endometriosis, and about 12% are estimated to be outside the abdominopelvic cavity - the most frequent location being the thorax. Endometriosis within the pulmonary parenchyma or on the diaphragm and…

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Machine Learning Classifiers for Endometriosis

Machine Learning Classifiers for Endometriosis By Dr. Youngran Park

Endometriosis is a complicated gynecological disorder that affects about 176 million women worldwide. It significantly impairs mental and physical quality of life in patients but the etiology is poorly understood. Endometriosis also causes a large economic burden due to loss…

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Transvaginal Ultrasound of Endometriosis

Transvaginal Ultrasound of Endometriosis By Murat Osman

A recent manuscript published by Collins et al. from the Department of Radiology at Penn State Hershey Medical Center aims to review the transvaginal ultrasound (TVUS) evaluation of endometriosis and offer a protocol that is dedicated to the thorough evaluation…

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Increased obstetrical complications after ART therapy in endometriosis patients.

Increased obstetrical complications after ART therapy in endometriosis patients. By Selma Oransay

To examine the impact of endometriosis and adenomyosis on ART therapy, Harada et al. from the Department of Obstetrics and Gynecology of Tottori University, Japan, planned a prospective cohort study and published their results recently in PLoS One.  The study…

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Endometriosis of the Appendix

Endometriosis of the Appendix By Timur Seckin

Endometriosis of the gastrointestinal tract is infrequent, and it rarely involves the appendix. A group of researchers from the United States of America reported a case of a 50-year-old postmenopausal woman with endometriosis in the vermiform appendix presenting as acute…

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Serum anti-Müllerian hormone levels for predicting spontaneous pregnancy after endometriosis surgery

Serum anti-Müllerian hormone levels for predicting spontaneous pregnancy after endometriosis surgery By Hale Goksever Celik

Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Although there are several medical and surgical therapeutic options, the most effective treatment modality has not yet been elucidated.    The main…

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Study Sheds Light on Physiological Processes Associated with Endometriosis

Study Sheds Light on Physiological Processes Associated with Endometriosis By Özge Özkaya

Sensory nerves play an important role in the development of endometriosis as well as fibrosis, confirms a study by Chinese researchers.  A better understanding of physiological processes associated with the development of endometriosis can help researchers devise new ways to…

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Endometriosis as an epigenetically regulated disease

Endometriosis as an epigenetically regulated disease By Dr. Youngran Park

Endometriosis is defined as the abnormal growth of endometrial tissue outside of the uterus. It affects about 10% of reproductive age women resulting in severe pain and infertility. Among various theories of endometriosis pathogenesis, not a single one has successfully…

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Consquences of endometriosis in menopausal period.

Consquences of endometriosis in menopausal period. By Selma Oransay

Marie-Scemama et al. from Foch Hospital, Suresnes, France, referred to endometriosis and menopause which is an actual cruising topic and recently published it in the journal named "Hormone Molecular Biology and Clinical Investigation". Endometriosis a well-known estrogen-dependent disease has three…

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Is there any difference between endometriosis patients with or without obliterated cul-de-sac during laparoscopic hysterectomy?

Is there any difference between endometriosis patients with or without obliterated cul-de-sac during laparoscopic hysterectomy? By Hale Goksever Celik

Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. It is diagnosed in 10% to 15% of reproductive-aged women. Women with endometriosis demand therapy for the most common symptoms, which are…

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A new technique for laparoscopic management of ovarian endometriosis.

 A new technique for laparoscopic management of ovarian endometriosis. By Selma Oransay

To cause a minimal hazardous effect on ovarian reserve during laparoscopic surgery of endometriomas is always a great concern for clinicians. Shaltout et al. from Cairo University, Egypt, examined the effect of "Surgicel" on preventing the recurrence of endometriomas and…

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Which surgical approach for bowel endometriosis?

Which surgical approach for bowel endometriosis? By Irem Onur

A group of researchers from Spain, led by Dr. Alicia Hernández Gutiérrez, conducted a retrospective study to compare postoperative complications and recurrence of three surgical techniques: segmental bowel resection (group I), discoid excision (group II), and rectal nodule shaving (group…

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Perinatal risk factors for endometriosis

Perinatal risk factors for endometriosis By Irem Onur

Gao M. et al., from Sweden analyzed the associations of maternal and birth characteristics with the risk of endometriosis among Swedish women of reproductive age. They have recently published their study in the "International Journal of Epidemiology". The authors conducted…

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New Protein for Endometriosis Diagnosis

New Protein for Endometriosis Diagnosis By Özge Özkaya

A protein called TIMP3 (tissue inhibitor of metalloproteinase-3) could be used for the diagnosis and prognosis (likely course) of endometriosis.  The early diagnosis of endometriosis is of paramount importance because it can help to diagnosis and thus initiate the right…

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Does ovarian endometriosis affect oocyte quality?

Does ovarian endometriosis affect oocyte quality? By Dr. Youngran Park

Endometriosis is a very common gynecological disorder affecting women in their reproductive years. It is reported that patients with endometriosis have reduced implantation and pregnancy rates compared to healthy women. According to the various previous studies, the quality of the…

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How does pregnancy affect endometriosis?

How does pregnancy affect endometriosis? By Hale Goksever Celik

Endometriosis is the localization of endometrial stromal and glandular cells outside the uterine cavity. Pregnancy is offered as a treatment option for patients with endometriosis because it causes atrophy of endometrial cells similar to progesterone treatment. Progesterone predominance during pregnancy,…

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Using social media to raise awareness for endometriosis

Using social media to raise awareness for endometriosis By Demet Candaş Green

Raise your hand if you have used internet or social media to search for information today. We all do, every single day. Whether it is a recipe, biography of a favorite singer, reviews of a new restaurant, or today’s weather,…

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Endometriosis and the quality of life

Endometriosis and the quality of life By Selma Oransay

Recent developments of technics and improvement of skill in the laparoscopic field increased the courage of clinicians to attempt early and multiple diagnostic operations on endometriotic patients. Vanuccini et al. from NEUROFARBA, University of Florence, Florence, Italy recently published their…

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Is there an association between endometriosis and sexual activity during menstruation ?

Is there an association between endometriosis and sexual activity during menstruation ? By Nasuhi Engin Aydin

This recent case-control study with 185 women having endometriosis and  370 women as a control group was conducted in Tebriz University, Iran by Dr. Mollazadeh and associates.  Contemporarily, retrograde menstruation is a valid theory for disseminating endometrial tissue to the…

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Analysis of childless women with endometriosis

Analysis of childless women with endometriosis By Irem Onur

Facchin F. et al., from Italy studied if the beliefs of childless women regarding motherhood, female identity, and infertility affected their psychological health. They have recently published their study in the Journal of Health Psychology. The data of this study were…

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How Long Does it Take to Be Diagnosed with Endometriosis?

How Long Does it Take to Be Diagnosed with Endometriosis? By Özge Özkaya

It takes a median of eight years to reach a diagnosis of endometriosis from when the symptoms of the condition first appear confirmed a new British study. Interestingly, it seems that the earlier the symptoms appear, the later the disease…

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Patients preferences for the treatment of endometriosis-associated pain

Patients preferences for the treatment of endometriosis-associated pain By Hale Goksever Celik

Endometriosis is defined as the location of endometrial stroma and glands outside the uterine cavity. The most common presenting complaints are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility, most of which relate to the menstrual period. Those women affected…

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MicroRNA Inhibitor as an Endometriosis treatment

MicroRNA Inhibitor as an Endometriosis treatment By Dr. Youngran Park

Endometriosis is a well-known estrogen-dependent gynecological disorder. This disease affects approximately 20% to 50% of infertile women and 10% of reproductive-aged women resulting in infertility and pelvic pains.  In order to find endometriosis-specific treatment, various studies have been tried to…

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Adolescent dysmenorrhea and future endometriosis

Adolescent dysmenorrhea and future endometriosis By Selma Oransay

Dysmenorrhoea is typically classified as primary, or secondary due to underlying pathologies like fibroids, endometriosis, adenomyosis or uterine anomalies. Generally, long-term dysmenorrhea is present in endometriotic patient's anamnesis, but until recently, the research to clarify this connection remained retrospective. Knox et…

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Impact of Endometriosis on Embryo Development

Impact of Endometriosis on Embryo Development By Dr. Youngran Park

Endometriosis is a hormone-dependent disorder which affects approximately 10% of women in reproductive age. There are many endometriosis-related problems, but infertility is one of the well-known issues which should be handled and understood. Despite numerous trials, the mechanisms and pathology…

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Clinical trial for the use of oral lactobacillus on endometriosis pain severity

Clinical trial for the use of oral lactobacillus on endometriosis pain severity By Yu Yu

The standard treatment of endometriosis consists of surgery and hormonal based treatment. There is evidence for the efficacy of these types of treatment, although their side effects remain a critical consideration for women. Based on molecular studies, changes in the…

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How to predict complications for endometriosis surgery?

How to predict complications for endometriosis surgery? By Timur Seckin

In a new study co-led by scientists at Sorbonne University, a nomogram is built to better inform patients about the risk of deep endometriosis surgery without bowel involvement. The findings have been published in the European Journal of Obstetrics &…

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Melatonin receptors and their role in endometrial cell proliferation

Melatonin receptors and their role in endometrial cell proliferation  By Hale Goksever Celik

Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Despite extensive research, the exact pathophysiological mechanism and the optimal management of endometriosis still remains unclear. Management of endometriosis should aim to relieve pain,…

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Atherosclerotic cardiovascular disease and endometriosis

Atherosclerotic cardiovascular disease and endometriosis By Nasuhi Engin Aydin

Dr. Omur Taskin and associates from British Columbia, Canada, have recently published a review regarding the potential link between atherosclerotic cardiovascular disease (ASCVD) and endometriosis in The Journal of Minimally Invasive Gynecology. Atherosclerotic cardiovascular disease is the leading cause of…

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Not a malignancy, it is "polypoid endometriosis"

Not a malignancy, it is By Irem Onur

Ghafoor S. et al., from Memorial Sloan Kettering Cancer Center, NY, USA, has recently reported a case of a 60-year-old postmenopausal woman with an incidental pelvic mass mimicking a pelvic malignancy on ultrasound. Their paper has been published in the…

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DNA repair defects and Endometriosis

DNA repair defects and Endometriosis By Dr. Youngran Park

Endometriosis is a hormone-dependent disorder and highly associated with inflammation. It is well suggested that endometriosis increases the risks of developing cancers such as ovarian, breast, endocrine, and colorectal cancers. Compared to cancer, there are many similarities in endometriosis. Well-known characteristics…

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What happens to women with endometriosis after menopause?

What happens to women with endometriosis after menopause? By Selma Oransay

Endometriosis affects women in their reproductive period of life, with expected regression of lesions in the postmenopausal period. Literature about postmenopausal endometriosis assessing the prevalence, pathogenesis, and treatment is limited. As 2-5 % of postmenopausal women are affected by this uncommon condition, developing stress…

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Disparities in Access to Healthcare in Women with Endometriosis

Disparities in Access to Healthcare in Women with Endometriosis By Özge Özkaya

There are significant differences in the use of medical services and prescriptions between women with endometriosis who have private healthcare and those who don’t. This is according to a study published in the American Journal of Obstetrics and Gynaecology.   This…

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A miniaturized version of endometrium: organoids for endometriosis research

A miniaturized version of endometrium: organoids for endometriosis research By Yu Yu

Organoids are a miniaturized version of a tissue that is produced in culture through three dimensions techniques in order to better mimic the tissues of origin. These cultures are supposed to better replicate the complexity of a biological organ/disease. Endometrial…

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The accuracy of "lower endoscopic ultrasound" for the preoperative diagnosis of rectosigmoid endometriosis

The accuracy of By Hale Goksever Celik

Endometriosis affects reproductive-aged women most frequently with a prevalence of 5% to 15%. If the endometriotic lesions involve the bowel especially sigmoid colon and rectum, this subtype of endometriosis is named as "bowel" or "rectosigmoid" endometriosis. Rectosigmoid endometriosis is encountered in…

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Plausible biomarkers for noninvasive endometriosis diagnosis

Plausible biomarkers for noninvasive endometriosis diagnosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent benign gynecological disease characterizing ectopic deposition of endometrial tissue outside of the uterine cavity. It affects about 10% of reproductive-aged women and causes enormous negative impacts on the quality of lives. However, we do not have…

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Nanotechnology as a tool for targeted therapy of endometriosis

Nanotechnology as a tool for targeted therapy of endometriosis By Murat Osman

Endometriosis is a process whereby endometrial cells persistently grow and invade extra-uterine tissue through a primarily estrogen-dependent manner. These ectopic endometrial cells proliferate in sometimes an uncontrolled manner, similar to cancer or inflammatory tissues. To proliferate, cells need cholesterol to…

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How to Classify Endometriosis for a better and effective evaluation

How to Classify Endometriosis for a better and effective evaluation By Selma Oransay

Endometriosis affects 10% of women in their reproductive period and causes infertility around 40% of women who have the disease. Peritoneal fluid may be one of the factors to facilitate the spread of endometriosis to ovaries, peritoneum and other deep…

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Mortality of 49956 midlife women with surgically verified endometriosis

Mortality of 49956 midlife women with surgically verified endometriosis By Irem Onur

Saavalainen L. et al., from Finland recently published a retrospective large cohort study in the journal Human Reproduction, where they retrospectively examined the data of surgically verified endometriosis patients to find out if all-cause and the cause-specific mortality rate is…

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Which Diagnosis Technique is Better?

Which Diagnosis Technique is Better? By Özge Özkaya

Transvaginal ultrasound provides a more accurate localization of vaginal and recto-vaginal endometriosis compared to magnetic resonance imaging (MRI) according to a study published in the International Journal of Gynecology & Obstetrics. However, MRI has better accuracy in detecting bladder endometriosis…

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Pregnancy with endometriosis

Pregnancy with endometriosis By Demet Candaş Green

Current literature suggests that complications of endometriosis during pregnancy are rare; however, a non-negligible increase in the likelihood of placenta accreta (placenta grows too deeply into the uterine wall), preterm birth, and cesarean delivery has been reported. With the increase…

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Prescription Opioid Use in Women With Endometriosis

Prescription Opioid Use in Women With Endometriosis By Deniz Kocas

In this study, researchers examined opioid use, opioid prescribing patterns, and timing of the first opioid prescription in endometriosis patients compared with matched women in the control group without endometriosis. A retrospective analysis of Optum Clinformatics Data Mart was conducted.…

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Infertility in women with endometriosis

Infertility in women with endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. The most common presenting complaints are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Despite extensive research, the etiopathogenic mechanism underlying the two has not been fully elucidated. Although human…

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The Effect of Imbalanced Progesterone Receptors-A/B on Gelatinase Expressions in Endometriosis

The Effect of Imbalanced Progesterone Receptors-A/B on Gelatinase Expressions in Endometriosis By Dr. Youngran Park

Endometriosis is a benign disease which affects approximately 10% of reproductive-aged women and is one of the most common reasons for infertility. Though the underlying mechanisms of disease progression have not been clearly understood, it develops as a consequence of…

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Fusion US/MR imaging in the evaluation of deep infiltrating endometriosis

Fusion US/MR imaging in the evaluation of deep infiltrating endometriosis By Timur Seckin

Scioscia M. et al., from Italy presented a case of a large deep infiltrating nodule of the uterosacral ligament and discussed the importance of a relatively new technique, fusion US/MR imaging in their article. The article containing a video of…

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Endometriosis that involves the nerves: how Radiologists can help

Endometriosis that involves the nerves: how Radiologists can help By Murat Osman

Endometriosis is a disease with variable clinical symptoms. While rare, nerve involvement by endometriosis may cause neurologic symptoms such as pelvic pain, muscle weakness, bowel and bladder incontinence, and paraplegia depending on the specific nerve involved. Thus, abdominal radiologists should…

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A position statement of diagnosing and treating endometriosis for gynecologists.

A position statement of diagnosing and treating endometriosis for gynecologists. By Selma Oransay

Endometriosis Treatment Italian Group recently declared 10 "valuable" conducts to evaluate endometriotic patients and published them in Hum. Reprod. Open. This society consists of 16 university departments and training center with expert clinicians on endometriosis from Italy. After arising the idea of…

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Botox as a promising treatment for chronic pelvic pain in endometriosis

Botox as a promising treatment for chronic pelvic pain in endometriosis By Irem Onur

Botulinum toxin (Botox) for treating chronic pelvic pain specifically addressing women with endometriosis has been studied for the first time by Tandon et al., from Bethesda, Maryland, USA. Their paper has recently been published in the journal Regional Anesthesia &…

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MRI or TVS for accurate diagnosis of rectosigmoid endometriosis?

MRI or TVS for accurate diagnosis of rectosigmoid endometriosis? By Demet Candaş Green

Rectosigmoid endometriosis (RE) is seen in about 90% of patients with bowel endometriosis. Rectosigmoid is the region between the rectum and the sigmoid colon, which is a region easily accessed and assessed by two most common noninvasive imaging modalities –…

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Health care resource utilization and cost in women with endometriosis

Health care resource utilization and cost in women with endometriosis By Hale Goksever Celik

Endometriosis is a chronic inflammatory disease affecting 6-10% of reproductive-aged women. The clinical picture of the disease range from asymptomatic findings to dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Endometriosis has also complex etiopathogenetic background. This broad clinical spectrum, the…

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Chronic Fatigue Syndrome and Endometriosis: Comorbid Conditions

Chronic Fatigue Syndrome and Endometriosis: Comorbid Conditions By Irem Onur

In the study of Dr. Boneva et al., from Atlanta, GA, the United States which has recently been published in the journal Frontiers in Pediatrics evaluated the impact of endometriosis on the health of women with chronic fatigue syndrome (CFS). The authors compared…

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Patients with Pelvic Pain Most Likely to Benefit from Endometriosis Surgery

Patients with Pelvic Pain Most Likely to Benefit from Endometriosis Surgery By Özge Özkaya

Women who experience higher levels of pain are more likely to show improvement in their quality of life (QoL) following endometriosis surgery, according to a study published in The Journal of Minimally Invasive Gynecology. Chronic pelvic pain seems to be…

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Surgical treatment of deeply infiltrating endometriosis in tertiary treatment centers

Surgical treatment of deeply infiltrating endometriosis in tertiary treatment centers By Demet Candaş Green

In the present study, data from patients who were surgically treated for deep infiltrating endometriosis (DIE) in a tertiary referral unit, the Avicenna Centre for Endometriosis and Minimally Invasive Gynecology (ACEMIG, Tehran, Iran), were examined for rates of intraoperative and…

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The predictors for the coexistence of uterine leiomyomas and endometriosis

The predictors for the coexistence of uterine leiomyomas and endometriosis  By Hale Goksever Celik

Uterine leiomyomas are the most common gynecological benign tumors affecting 20-25% of reproductive-aged women. Abnormal bleeding, pelvic pain, pelvic pressure, and infertility are major symptoms of these tumors. Endometriosis is another gynecological disease encountered in 10-15% of reproductive-aged women. The…

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Control on endometriosis progression by a "tyrosine kinase inhibitor"

Control on endometriosis progression by a By Irem Onur

B cells, which are important players of the immune system, are increased in the blood and peritoneal cavity of endometriosis patients. Activation of B cells and the presence of anti-endometrial autoantibodies have been also been described in women with endometriosis,…

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Transvaginal Ultrasound and the Imaging of Endometriosis

Transvaginal Ultrasound and the Imaging of Endometriosis By Murat Osman

Ultrasonography (US) is an imaging tool that uses sound waves to produce a two-dimensional picture inside of the body. The ultrasonography has become especially useful in the assessment of gynecologic pathologies such as endometriosis. Depending on the severity of endometriosis,…

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Importance of monocytic myeloid derived supressor cells in endometriosis

Importance of monocytic myeloid derived supressor cells in endometriosis By Nasuhi Engin Aydin

Myeloid-derived suppressor cells MDSCs are immature myeloid cells that play a major role in immunosuppression in various disease processes.  Ya Sun and associates have investigated these cells in endometriosis utilizing various laboratory methods. published their results in the "American Journal of…

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"Endometriosis", "Fibromyalgia" and "Autoimmune diseases"

By Irem Onur

Greenbaum et al. from Israel, investigated the prevalence of and the association between endometriosis, fibromyalgia and autoimmune diseases in a large population database and described healthcare resource utilization in affected women. Their study has been published in the "American Journal…

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Seven Hormonal Biomarkers for Diagnosing Endometriosis

Seven Hormonal Biomarkers for Diagnosing Endometriosis By Dr. Youngran Park

Endometriosis is an inflammatory condition characterized by implantation and invasive growth of endometrial tissue outside the uterine cavity. Although it is benign, endometriosis has cancer-like features, a mutation profile similar to that of ovarian cancer, and increased ovarian cancer risk.…

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Baby Years and the Risk of Endometriosis

Baby Years and the Risk of Endometriosis By Özge Özkaya

Early-life factors such as whether a baby was breastfed, have had vaginal bleeding at birth, or whether or not their father was a smoker may be associated with her risk of developing endometriosis in later life.  This is according to…

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Analogous pathways of peritoneal tumor wound healing and endometriosis.

Analogous pathways of  peritoneal tumor wound healing and endometriosis. By Selma Oransay

Endometriosis, diagnosed around 10-15% of women population in their reproductive period, is a chronically progressive inflammatory disease to cause peritoneal lesions while spreading into the abdominal cavity. The pathophysiology of the adhesions between the peritoneum and pelvic organs can be…

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Endocrine-disrupting chemicals – yet another environmental factor associated with endometriosis?

Endocrine-disrupting chemicals – yet another environmental factor associated with endometriosis? By Demet Candaş Green

This study by Wen et al., published in Gynecological Endocrinology, analyzed evidence connecting endocrine-disrupting chemicals (EDCs) to the incidence of endometriosis in a collection of 30 previously published studies. Results show that exposure to many EDC's are linked to the…

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Urocortin: A biomarker deserving investigation for endometriosis patients

Urocortin: A biomarker deserving investigation for endometriosis patients By Irem Onur

Urocortin is a neuropeptide in the corticotropin-releasing hormone family and is expressed by eutopic and ectopic human endometria. Since it has paracrine and immunomodulatory effects, urocortin is thought to contribute to the pathogenesis of endometriosis. Its expression has been thoroughly…

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The coelomic metaplasia hypothesis of endometriosis in MRKH cases

The coelomic metaplasia hypothesis of endometriosis in MRKH cases By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity and its incidence is approximately 10% in the general female population. Although the pathophysiological mechanism is not clearly understood, the implantation theory by Sampson…

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ENDORECT scoring system to identify patients at risk for rectosigmoid endometriosis

ENDORECT scoring system to identify patients at risk for rectosigmoid endometriosis By Murat Osman

Patients who suffer from endometriosis may benefit from a preoperative score that predicts rectosigmoid involvement. A recent paper published by Huchon et al. at Poissy Saint-Germain en Laye, France, recruited 119 women who underwent laparoscopy for endometriosis between 2011 and…

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Endometriosis pathophysiology: research in genes updated

Endometriosis pathophysiology: research in genes updated By Nasuhi Engin Aydin

Endometriosis has a broad spectrum of environmental influences and genetic factors. I In this recently published review article in Experimental and Therapeutic Medicine, Vassilopoulou and associates present information about gene‑gene and gene‑environment interactions involved in endometriosis and discuss the effectiveness…

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Novel inhibitors of estrogen biosynthesis

Novel inhibitors of estrogen biosynthesis By Dr. Youngran Park

Endometriosis is a chronic benign disease which is estrogen-dependent. Estradiol creates a positive feedback loop with the synthesis of pro-inflammatory mediators, which sustains further disease establishment and causes the pain symptoms. However, hormone therapies do not cure definitively endometriosis, because…

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Searching new biomarkers for endometriosis

Searching new biomarkers for endometriosis By Selma Oransay

This recent article published in Advances in Clinical Chemistry, is an overall summary of characteristics, physiopathological theories, diagnostic approaches and variety of biomarkers to diagnose endometriosis and penned by Coutinho et al. from Universidade Federal de Juiz de Fora, Belo Horizonte,…

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The association of significant hemoperitoneum (blood in the abdominal cavity) and deep pelvic endometriosis

The association of significant hemoperitoneum (blood in the abdominal cavity) and deep pelvic endometriosis By Irem Onur

 Although there are several theories to explain the etiology of deep endometriosis, the cause is unknown and there are currently no effective strategies to prevent its development. Bean E. et al., from University College London Hospital, UK,  observed that some…

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The Wnt/b-catenin signaling in endometriosis

The Wnt/b-catenin signaling in endometriosis By Dr. Youngran Park

Endometriosis is a very common gynecological disorder, which affects approximately 10% of reproductive-aged women, and is one of the most common reasons for infertility. The normal endometrium undergoes cyclical remodeling under control of sex hormones secreted by ovaries- estrogen and…

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Non‑invasive biomarkers for endometriosis diagnosis

Non‑invasive biomarkers for endometriosis diagnosis By Hale Goksever Celik

Endometriosis is a disease of women in reproductive age and its incidence varies between 5-10%. Since the diagnosis is based on the histological confirmation, there is an average of 7 to 11 years of delays in the diagnosis. Promising non-invasive…

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The reason for lower BMI and less body fat in women with endometriosis.

The reason for lower BMI  and less body fat in women with endometriosis. By Selma Oransay

Zolbin et al. from the Department of Obstetrics and Gynecology of Yale School of Medicine, New Haven, USA, recently published the results of their prospective controlled research on adipocyte alterations in endometriosis, in the journal "Reproductive Biology and Endocrinology". Endometriosis can…

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Fibrogenesis in endometriosis: The role of neuropeptides

Fibrogenesis in endometriosis: The role of neuropeptides By Dr. Youngran Park

Endometriosis is a debilitating gynaecologic disease affecting 6–10% of women of reproductive age. Endometriotic lesions are known to be hyperinnervated due to neurogenesis resulting from neutrophins secreted by endometriotic lesions and possibly platelets. These neutrophins seem to preferentially favor the…

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Pathophysiology of peritoneal endometriosis pain.

Pathophysiology of peritoneal endometriosis pain. By Serdar Balci

This article is an invited editorial by Ferrero S et.al. from IRCCS Ospedale Policlinico San Martino, Genoa, Italy, published in the Annals of Translational Medicine. The authors describe the pathophysiology and underlying mechanisms of pain in peritoneal endometriosis with reference to the…

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The genetic predisposition to endometriosis

The genetic predisposition to endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. Although endometrium is a non-malignant disease, its symptoms can range from mild to severe due to the inflammation that ectopic endometrial tissue forms around itself. The exact etiopathogenetic mechanism…

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A new hope for a "targeted" drug for endometriosis

A new hope for a By Selma Oransay

Lin et al. from National Cheng Kung University, Taiwan, recently published in"Theranostics" the article entitled "Targeting Anthrax Toxin Receptor 2 Ameliorates Endometriosis Progression”,  report that ANTRX2 may be a novel therapeutic target for endometriosis. Thinking that the adhesion should be the first and the…

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Anti-angiogenic treatment for endometriosis

Anti-angiogenic treatment for endometriosis By Dr. Youngran Park

Endometriosis is a benign, estrogen-dependent gynecological disorder. The wide variety of surgical and medical treatment has been applied for treating endometriosis, but a definitive therapy has not been achieved so far. Thus, new therapeutic strategies need to be developed. Among…

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Proposed algorithm for a clinical diagnosis of endometriosis.

Proposed algorithm for a clinical diagnosis of endometriosis. By Selma Oransay

This recently published article in the American Journal of Obstetrics and Gynecology is about the challenge of diagnosing endometriosis, its impact on women's daily life and authored by Agarwal et al. from The University of California, San Diego, CA, USA. Authors called attention…

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Adenomyosis (endometriosis interna): an enigmatic disease that has to be discovered yet

Adenomyosis (endometriosis interna): an enigmatic disease that has to be discovered yet By Nasuhi Engin Aydin

Scientists, Drs. Vannuccini and Petraglia from Italy have published an open access comprehensive review of Adenomyosis in "F1000Research" in March 2019 issue. Adenomyosis is a uterine disorder in which endometrial glands and stroma are pathologically demonstrated within the myometrium, i.e.…

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Endometrial single cells to contribute preexisting endometriosis.

Endometrial single cells to contribute preexisting endometriosis. By Dr. Youngran Park

Endometriosis is an estrogen-dependent inflammatory disease. This disease affects approximately 10% of reproductive-aged women and 20% to 50% of infertile women. Multiple hypotheses have been proposed for the origin of endometriosis. Retrograde menstruation is believed to take part by the…

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Reducing the Risk of Recurrence After Endometriosis Surgery

Reducing the Risk of Recurrence After Endometriosis Surgery By Özge Özkaya

The use of compounds called NF-κB inhibitors and β-blockers before and after endometriosis surgery may reduce the risk of the disease recurring, according to a study conducted in a mouse model. According to the study published in the journal Reproductive…

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Antibiotic therapy for endometriosis

Antibiotic therapy for endometriosis By Yu Yu

Current treatments for endometriosis are surgery and hormone therapy; however, these approaches may have significant side effects and do not prevent a recurrence. Therefore, alternative treatment modalities for endometriosis is needed. Recently, the idea that endometriosis may be influenced by…

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The postoperative functional outcomes of deep infiltrating endometriosis

The postoperative functional outcomes of deep infiltrating endometriosis By Hale Goksever Celik

Rectosigmoid endometriosis is defined as the infiltration of the bowel wall with the endometrial-like glands and stroma, reaching at least the muscular layer. The most commonly involved sites are the rectum and sigmoid colon. For the management of deep infiltrating…

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A new trial to reduce the failure of IVF/ICS protocols in severe endometriosis

A new trial to reduce the failure of IVF/ICS protocols in severe endometriosis By Selma Oransay

Kong et al., from the first affiliated hospital of Zhengzhou University, China, recently published this single-blinded, a multicentered and randomized controlled study in the Journal of Reproductive Health, with the aim to find a safer and more effective ovulation induction regimen for patients with…

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Endometriosis and nuclear receptors

Endometriosis and nuclear receptors By Dr. Youngran Park

It is well recognized that endometriosis is a steroid-dependent disorder. In endometrial stromal cells, progesterone regulates retinoic acid production and action. Retinoids also act via a number of nuclear receptors (NRs) and are involved in normal endometrial function and endometriosis. Estrogen…

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Bladder Endometriosis

Bladder Endometriosis By Demet Candaş Green

Bladder endometriosis is rare – about 1-2% of women with endometriosis may have endometrial lesions in their urinary tract. Diagnosis of bladder endometriosis is difficult because of its nonspecific symptoms such as frequent urination, pelvic pain, and burning sensation when…

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The coexistence deep infiltrating endometriosis and fibromyalgia

The coexistence deep infiltrating endometriosis and fibromyalgia By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The main symptoms of endometriosis which are dysmenorrhea, dyspareunia, and chronic pelvic pain impair the quality of life of these women. This disease may…

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MRI-based "ENZIAN" scoring system and intra-operative endometriosis findings

MRI-based By Murat Osman

Endometriosis is a chronic inflammatory disease whereby endometrial-like glands grow and invade the extra-uterine structures. Endometriosis may affect various parts of the body, including the peritoneum, ovaries, or retroperitoneum. Recently, non-invasive methods for detecting these lesions have included trans-vaginal ultrasound…

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Epithelial Mutations in Endometriosis

Epithelial Mutations in Endometriosis By Dr. Youngran Park

A substantial body of epidemiologic evidence suggests a link between endometriosis and epithelial ovarian cancer, but a plausible underlying mechanism has remained elusive. Here, Dr. Bulun group from Northwestern University provide a focused review of the literature and discuss the…

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A highly sensitive Immunohistochemical Marker for Stromal Cells in endometriosis

A highly sensitive Immunohistochemical Marker for Stromal Cells in endometriosis By Nasuhi Engin Aydin

Endometriosis is diagnosed histopathologically by the presence of endometrium-like tissues outside the uterus. Positive CD10 immunohistochemistry, highlighting stromal cells of the endometrium, is a useful adjunct for pathologists in the tissue diagnosis. However, CD10 expression is not specific to endometrial stromal…

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A guide on the Assessment of Pelvic Endometriosis Imaging

A guide on the Assessment of Pelvic Endometriosis Imaging By Murat Osman

Endometriosis is a disease whereby ectopic endometrial-like tissue invades and survives outside of the endometrial cavity. While biopsy-proven confirmation of endometriosis during laparoscopy has been considered the gold standard for diagnosis, non-invasive imaging modalities are increasingly being utilized for preoperative…

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Can early-life exposures affect endometriosis development later in life?

Can early-life exposures affect endometriosis development later in life? By Demet Candaş Green

Endometriosis is a complex disease with possible multifactor contributors. So far, inflammatory, immunogenic, genetic, and environmental factors have all been associated with endometriosis. In addition, it is possible that different types of endometriosis lesions – peritoneal, ovarian, and deep infiltrating…

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Choosing the Right Technique for Deep Colorectal Endometriosis

Choosing the Right Technique for Deep Colorectal Endometriosis By Dr. Youngran Park

Endometriosis is a benign gynecologic condition, histologically defined by the presence of ectopic endometrium outside the endometrial cavity. Three clinical presentations of endometriosis have been described and could coexist in the pelvis: peritoneal endometriosis, ovarian endometriosis, and deep infiltrating endometriosis.…

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Ovarian stimulation regimes: Concerns on progression or recurrence of endometriosis

 Ovarian stimulation regimes: Concerns on progression or recurrence of endometriosis By Selma Oransay

Somigliana et al., from the University of Milan, Italy, performed a literature review to predict the endometriosis-enhancing effect of ART regimes on infertile women and reported their results in Reproductive Biomedicine Online. Their points of interest were increasing dysmenorrhea, dyspareunia, non-menstrual pain and…

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Preoperative factors to predict unresponsiveness in women undergoing endometriosis surgery

Preoperative factors to predict unresponsiveness in women undergoing endometriosis surgery By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Despite extensive research, the optimal management of endometriosis still remains unclear. Several treatment options include analgesic medication, hormonal treatments, and surgical intervention. There is…

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Impact of Endometriosis-Related Adhesions on Quality of Life among Infertile Women

Impact of Endometriosis-Related Adhesions on Quality of Life among Infertile Women By Dr. Youngran Park

Endometriosis is considered the most common cause of pelvic adhesions in women. It is considered one of the main underlying causes of the development of adhesions. Adhesions are bands of connective tissue, which connect two different tissues that are normally…

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Menstrual blood-derived stem cells

Menstrual blood-derived stem cells By Selma Oransay

Chen et al.  from the Center of Diagnosis and Treatment of İnfectious Disease, Zhejiang University, China penned this recent review in the Journal of Stem Cell Research Therapy which is presenting the clinical potential of MenSCs (Menstrual blood-derived stem cells). …

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Endometriosis involving the superficial peritoneum in Adolescents: Surgical Management

Endometriosis involving the superficial peritoneum in Adolescents: Surgical Management By Murat Osman

Endometriosis is a chronic disease whereby endometrial glands and stroma grow and survive outside of the uterus. In some cases, endometriosis may become symptomatic and cause debilitating, chronic pelvic pain. Among pelvic organ and other surfaces that endometriosis can involve…

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Polymorphisms of STAT4 gene in the pathogenesis of endometriosis

Polymorphisms of STAT4 gene in the pathogenesis of endometriosis By Dr. Youngran Park

Endometriosis is one of the most common gynecological diseases in reproductive-age women characterized by the occurrence of endometrial tissue outside the uterine cavity. Researchers have put forward numerous hypotheses to explain ectopic endometrial tissue, and the bulk of the evidence…

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The appearance of postoperative endometriosis by imaging methods

The appearance of postoperative endometriosis by imaging methods By Hale Goksever Celik

Endometriosis is a chronic gynecological disease mostly encountered in reproductive-aged women. Endometriosis can occur in three different entities: peritoneal, ovarian and deep endometriosis. Golden standard diagnosis is made by histopathological examination of surgical material after laparoscopic surgery in women with…

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Endometriosis and infertility: current concepts

Endometriosis and infertility: current concepts By Nasuhi Engin Aydin

Hungarian and US scientists have published a comprehensive review on infertility related to endometriosis in Frontiers in Endocrinology, November 2018 issue.  Endometriosis is a common entity in women of reproductive age which often leads to infertility. Compiled research data reveal…

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Gal-3 can be a pharmacological target in endometriosis treatment

Gal-3 can be a pharmacological target in endometriosis treatment By Demet Candaş Green

Galectins are known to play a significant role in angiogenesis, which is a key event contributing to the development of many disease conditions, one of which is endometriosis. Past studies, upon examining several human endometriotic lesions, showed that Galectin-3 (Gal-3)…

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Estrogen Receptor Signaling and Endometriosis-Associated Ovarian Cancer

Estrogen Receptor Signaling and Endometriosis-Associated Ovarian Cancer By Selma Oransay

Andersen et al. published a prospective cohort study in the Journal of Hormones and Cancer to enlighten the estrogen signaling pathway during the transition from endometriosis to endometriosis-associated ovarian cancer. Given the shared pathway of endometriosis and ovarian cancer as…

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Immunologic Disorder in the Progression of Endometriosis

Immunologic Disorder in the Progression of Endometriosis By Dr. Youngran Park

Endometriosis becomes increasingly a health-social problem. However, definite diagnostic biomarkers and more effective treatments for endometriosis are still missing to this day.  Many researchers focus on the peritoneal microenvironment of patients with endometriosis, especially the immunological microenvironment. Recently, Jørgensen et…

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The miscarriage rate in women with endometriosis undergoing IVF fresh cycles

The miscarriage rate in women with endometriosis undergoing IVF fresh cycles By Hale Goksever Celik

Endometriosis is a chronic estrogen-dependent disease diagnosed in 25-40% of women with infertility. There are several mechanisms explaining the negative impacts of endometriosis on fertility through the entire reproductive process such as sperm-oocyte interaction, ovarian reserve, and implantation. Endometriosis is…

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Long non‐coding RNA, Epithelial mesenchymal transition, and Endometriosis

Long non‐coding RNA, Epithelial mesenchymal transition, and Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen‐dependent inflammatory gynecologic disease and requires attention. However, an in‐depth understanding of the latent pathogenesis of endometriosis development and its new innovative therapeutics are urgently needed. Epithelial‐mesenchymal transition (EMT) refers to the special biological process of epithelial…

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Which comes first in endometriosis management: In vitro fertilization or surgery?

Which comes first in endometriosis management: In vitro fertilization or surgery? By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence is found to be 7%–10%, but among infertile women, it increases up to 50%. Early diagnosis and personalized management are important to…

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Self-management of endometriosis symptoms: from Australia

Self-management of endometriosis symptoms: from Australia By Demet Candaş Green

Effective self-management techniques and lifestyle changes may play an important role in the management of endometriosis symptoms by many women. Due to various reasons such as limited effectiveness of some medications, potential side effects, availability of medical resources, self-desire to…

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Priorities and Unmet Needs of Endometriosis Management

Priorities and Unmet Needs of Endometriosis Management By Murat Osman

Endometriosis is a systemic, chronic disease that is a significant contributor to morbidity in young women. Although endometriosis has gained increasing attention in the medical field, scientific progress for an effective and definitive treatment modality is progressing slowly. The Society…

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Endometrioma, Fertility, and Assisted Reproduction

Endometrioma, Fertility, and Assisted Reproduction By Dr. Youngran Park

Endometriosis can negatively impact a woman’s health and quality of life. Surgery has been considered the primary treatment to overcome infertility in cases of ovarian endometrioma. Patients struggling with endometriosis often pursue assisted reproductive technologies (ART) due to fertility issues.…

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Building an ultrasonographic database for superficial endometriosis.

Building an ultrasonographic database for superficial endometriosis. By Selma Oransay

Chowdary et al. from University of Auckland, Australia, recently published a retrospective, small group study in Australian New Zeland Journal of Obstetrics and Gynecology, to demonstrate ultrasonographic findings of mild endometriosis patients with pelvic pain are associated with their laparoscopic diagnosis.…

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PAX8 immunohistochemistry in the diagnosis of Extragenital Endometriosis

PAX8 immunohistochemistry in the diagnosis of Extragenital Endometriosis By Serdar Balci

This study is performed by Arakawa T et al., from the University of Tokyo, Tokyo, Japan, and the results are published in Reproductive Sciences. Endometriosis is seen in many organs including peritoneum, ovaries, bowel, bladder, and even lung. Histopathologic diagnosis may…

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The association between the development of endometriosis and dietary habits

The association between the development of endometriosis and dietary habits By Hale Goksever Celik

Endometriosis is a chronic disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence is found to be approximately 10% in the general population. Endometriosis is associated with infertility, pelvic pain, and increased…

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Bowel endometriosis: What you need to know

Bowel endometriosis: What you need to know By Demet Candaş Green

When the endometrial tissue infiltrates the intestinal walls and reaches inside the intestines, this condition is called "bowel endometriosis". It is estimated that between 3.8% and 37% of women with endometriosis are affected by bowel endometriosis. The endometriosis lesions infiltrating…

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Signs and Symptoms on Transvaginal Ultrasound associated with the presence of endometriosis.

Signs and Symptoms on Transvaginal Ultrasound associated with the presence of endometriosis. By Murat Osman

Endometriosis is a disease whereby ectopic endometrial cells are present outside of the uterus. Transvaginal ultrasound (TVUS) is a highly specific test for endometriomas and deep endometriosis to assess the involvement of endometriosis in the posterior anatomic compartments. While the…

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Exosome: a new avenue for endometriosis research

Exosome: a new avenue for endometriosis research By Dr. Youngran Park

Endometriosis affects 10% of reproductive-aged women. The pathophysiology of this disease remains mysterious, with a lack of effective biomarkers necessitating surgical intervention for diagnosis. This creates an urgent need for accurate noninvasive diagnostic tests and the identification of effective therapeutic…

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Additional research in understanding the causative link between Notch signaling and endometriosis

Additional research in understanding the causative link between Notch signaling and endometriosis By Nasuhi Engin Aydin

Dustin M. Brown and associates from the University of Arkansas for Medical Sciences published their unique complex molecular research in the Journal of the Endocrine Society. This study group previously showed that decreased expression of the progesterone receptor (PGR) resulted from…

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Can we prevent the progression of endometriosis?

Can we prevent the progression of endometriosis? By Selma Oransay

Torres-Reveron et al. from the University of Texas, USA, planned this prospective laboratory research on female rats to assay the reduce on the progression of endometriosis and recently published the results in PloS One. At first,  endometriosis was induced in female rats…

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Endometriosis and female pelvic pain in all aspects

Endometriosis and female pelvic pain in all aspects By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence of the disease ranges between 6-10% in reproductive-aged women. However, endometriosis is more frequently encountered in women with chronic pelvic pain and…

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The relationship between periodontal disease and endometriosis

The relationship between periodontal disease and endometriosis By Irem Onur

Thomas et al. have recently studied the association between endometriosis and periodontal disease which may share a common pathogenesis, and have published it in the Journal of Human Reproductive Sciences. The authors screened a total of50 women; 25 with and 25…

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Clonal Proliferation and Cancer Associated Mutations in normal uterine endometrium and endometriosis

Clonal Proliferation and Cancer Associated Mutations in normal uterine endometrium and endometriosis By Serdar Balci

Suda et. al., from Niigata University, Japan, has published the article entitled "Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium" in Cell Reports. There are many theories for endometriosis development (retrograde menstruation, coelomic metaplasia, Müllerian remnants),…

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Vaginal Sexual Intercourse during Menstruation

Vaginal Sexual Intercourse during Menstruation By Irem Onur

Mazokopakis and Samonis from Greece examined and discussed the vaginal sexual intercourse during menstruation from a biblical as well as a modern medical point of view in their paper published in MAEDICA – a Journal of Clinical Medicine in September 2018.…

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Somatic mutations in iatrogenic endometriosis.

Somatic mutations in iatrogenic endometriosis. By Selma Oransay

Lac and al., from the Department of Molecular Oncology in BC Cancer Research Center, Vancouver, Canada, planned a retrospective and multinational research to investigate the prevalence of somatic cancer-driver mutations in incisional endometriosis and recently published in the "Journal of Human Reproduction". Their…

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Mistletoe as a Potential Candidate for Endometriosis Treatment

Mistletoe as a Potential Candidate for Endometriosis Treatment By Dr. Youngran Park

Endometriosis, one of the common benign gynecologic disorders, is defined as the ectopic presence of endometrial cells outside of the uterine cavity. Although the underlying mechanisms are not fully understood, the most accepted hypothesis is that endometrial cells pass through…

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Surgical techniques for rectosigmoid endometriosis, and functional outcomes

Surgical techniques for rectosigmoid endometriosis, and functional outcomes By Hale Goksever Celik

Rectosigmoid endometriosis is defined as the infiltration of bowel wall with the endometrial-like glands and stroma, reaching at least the muscular layer. Rectosigmoid endometriosis is encountered in approximately 8-12% of patients with a diagnosis of endometriosis. The most commonly involved…

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A new theory in the pathogenesis of endometriosis

A new theory in the pathogenesis of endometriosis By Serdar Balci

Koninckx et. al., from various countries, have conducted this review, which will be published in Fertility and Sterility. Endometriosis is known for a century. The disease has a variable course in a patient, which may include pain, infections, and infertility.…

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Development of Less Invasive Diagnostic Tests for Endometriosis Through Proteomics

Development of Less Invasive Diagnostic Tests for Endometriosis Through Proteomics By Murat Osman

Proteomics is a field which utilizes various methods to carry out large-scale studies of proteins. Due to the inherent nature of the field, proteomics focuses on the identification, localization, and functional analysis of the protein make-up of a given type…

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New scientific evidence supporting robotic surgical approach to ureteric endometriosis

New scientific evidence supporting robotic surgical approach to ureteric endometriosis By Nasuhi Engin Aydin

Surgical treatment of ureteral endometriosis aims to relieve urinary obstruction besides preserving renal functions. In accomplishing these, the best method of surgical approach is still unclear. Andrea Giannini and her colleagues from the University of Pisa, Italy conducted a retrospective…

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Conservative Surgery May Be Sufficient to Halt the Development of Deep Endometriosis

Conservative Surgery May Be Sufficient to Halt the Development of Deep Endometriosis By Özge Özkaya

Deep endometriosis develops as a result of collective cell migration and nerve recruitment from surrounding organs, suggests a study published in the scientific journal Fertility and Sterility.   Collective cell migration is the biological process whereby a group of cells moves…

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The association of endometriosis and peritoneal malignant mesothelioma

The association of endometriosis and peritoneal malignant mesothelioma By Irem Onur

Endometriosis is well known to cause chronic inflammation of the serosa and incite mesothelial hyperplasia. Although multilocular peritoneal inclusion cysts and well-differentiated papillary mesothelioma were reported to be associated with endometriosis, the association of malignant mesothelioma has not been reported…

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Is the mystery for progression of endometriosis hiding out in abnormally located endometrial cells?

Is the mystery for  progression of endometriosis hiding out in abnormally located endometrial cells? By Selma Oransay

This prospective study was conducted by Hapangama et al. in Research İnstute of the University of Liverpool, UK, and the results have recently published in the Journal of Human Reproduction. The authors hypothesized that abnormally located endometrial basalis-like (SSEA1/nSOX9+)cells could be contributing to…

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The role of circulating microRNA's in Endometriosis

The role of circulating microRNA's in Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. This disease affects approximately 10% of reproductive-aged women and 20% to 50% of infertile women. Steroidogenic factor 1 (SF-1) is an essential transcriptional regulator coordinately regulating multiple genes involved in estrogen biosynthesis. SF-1 is known…

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Endometriosis-associated pain control by contraceptive implant or intrauterine system

Endometriosis-associated pain control by contraceptive implant or intrauterine system By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The most common symptoms are dysmenorrhea, dyspareunia, and chronic pelvic pain, all of which affect the quality of women’s lives. Several studies investigating the…

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Factors related to delay in endometriosis diagnosis

Factors related to delay in endometriosis diagnosis By Nasuhi Engin Aydin

Dr. Moniek van der Zanden, a gynecologist from Netherlands has recently made a nationwide survey on the impact of key recommendations of the European Society of Human Reproduction and Embryology (ESHRE) guidelines on endometriosis and aimed to assess factors influencing diagnostic delay of…

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Does the presence of endometriosis increase the risk of gynecologic malignancies?

Does the presence of endometriosis increase the risk of gynecologic malignancies? By Serdar Balci

Endometriosis shares common risk factors with endometrial carcinoma and ovarian carcinomas such as obesity, type 2 diabetes, hyperestrogenism, and reproductive characteristics. Endometriosis is also known to be a risk factor for gynecologic malignant tumors. In this study, Li et.al. have…

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Extragenital endometriosis and ultrasound

Extragenital endometriosis and ultrasound By Irem Onur

Contrast-enhanced ultrasound (CEUS) is a non-invasive imaging method with no exposure to radiation. There are a few reports on the use of CEUS in the assessment of endometriosis in the literature. Dong et al. reported 3 histopathologically proven cases of…

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Lipophilic Statins inhibit growth and invasiveness of human endometrial cells

Lipophilic Statins inhibit growth and invasiveness of human endometrial cells By Murat Osman

Endometriosis is a disease process whereby cells of the endometrium grow and invade structures outside of the uterus. Through recent research, it has been seen that endometriotic foci in women with endometriosis exhibit an altered phenotype that contributes to its…

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Can we Inhibit the Survival of Endometriosis?

Can we Inhibit the Survival of Endometriosis? By Dr. Youngran Park

Endometriosis is an estrogen-dependent gynecological inflammatory disease. The current anti-estrogen therapies can be prescribed only for a short time due to the undesirable side effects on menstruation, pregnancy, bone health, and recurrence. Therefore, the development of specific therapy which targets…

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Pelvic pain, congenital genital tract anomalies and endometriosis

Pelvic pain, congenital genital tract anomalies and endometriosis By Hale Goksever Celik

Any failure during development and differentiation of female genital tract results in congenital tract anomalies. The origin of the hymen is the union of the caudal portion of the paramesonephric ducts and the urogenital sinus. It functions as a mechanical…

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Further Results From the FEELING Study Published

Further Results From the FEELING Study Published By Özge Özkaya

Some women are more likely to develop deep infiltrating endometriosis according to the further analysis of the results of the FEELING study. These are women who: are married, are older,  have siblings,  have had a prior pregnancy,  or for whom…

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What clinicians know about adenomyosis? Any association with severe endometriosis?

What clinicians know about adenomyosis? Any association with severe endometriosis? By Selma Oransay

Dior et al. from the Royal Women's Hospital in Parkville, Australia, designed a prospective study to assess the association between severity of endometriosis and sonographic evidence of adenomyosis (SEOA) in their recently published article appearing in The Journal of Minimally…

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Immune dysregulation in endometriosis

Immune dysregulation in endometriosis By Yu Yu

The connection between endometriosis and the immune system has long been proposed. However, to date, there is no real consensus on whether immune adaptations actually facilitate endometriotric lesion progression or they are a consequence of endometriosis re-occurrence. Thus, this article…

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Targeted therapy biomarkers in endometriosis associated ovarian carcinomas

Targeted therapy biomarkers in endometriosis associated ovarian carcinomas By Serdar Balci

Endometriosis in ovaries is a known precursor of endometrioid and clear cell carcinomas. They may be resistant to classical therapies. Researchers search for alternative and targeted therapy options. This study, from the University of Campinas, Campinas, São Paulo, Brazil, will be…

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A Brief Review of Endometriosis

A Brief Review of Endometriosis By Timur Seckin

Endometriosis is a common disease among women of reproductive age. It is more frequently seen among women without prior pregnancies, women with a family history of endometriosis, and women with abnormal menstrual periods. Peiris et al., researchers from the United…

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Endometriosis: A review on anatomic principles and the management

Endometriosis: A review on anatomic principles and the management By Irem Onur

In the study of Alimi et al. which has been published in the journal Cureus, various aspects of endometriosis such as the pathophysiology, the anatomy, the pain mechanism, the perineural spread theory, clinical manifestations, diagnosis, and imaging, infertility, unusual cases,…

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Laparoscopic mesenteric vascular and nerve sparing surgery as a tool for DIE resection

Laparoscopic mesenteric vascular and nerve sparing surgery as a tool for DIE resection By Murat Osman

Endometriosis can be characterized by a wide range of clinical aggressiveness based upon the location, character, and growth of ectopic endometrial implants. As one of the most aggressive forms of endometriosis, deep infiltrating endometriosis (DIE) is known to involve the…

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Are women with histologically confirmed endometriosis satisfied with their medical support?

Are women with histologically confirmed endometriosis satisfied with their medical support? By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The most common symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, dyschesia, dysuria, musculoskeletal pain, fatigue and infertility, all of which affect the quality of…

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Anti-proliferative and anti-inflammatory effects of "Quercetin" on endometriosis

 Anti-proliferative and anti-inflammatory effects of By Dr. Youngran Park

Quercetin is a major flavonol that is mainly derived from capers and involves a daily consumption of approximately 25–50 mg through various vegetables. In recent studies, Quercetin is reported as a functional compound in obesity, diabetes and cardiovascular diseases. This compound…

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The use of Elagolix in Women with Liver and Kidney Impairments

The use of Elagolix in Women with Liver and Kidney Impairments By Özge Özkaya

Elagolix may be used in women with moderate liver impairment, when necessary, for up to six months at a dose of 150 mg a day, according to a study published in the scientific journal Clinical Pharmacology in Drug Development. The…

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Progesterone Receptor Status in Endometriosis

Progesterone Receptor Status in Endometriosis By Serdar Balci

Some patients do not respond to progesterone hormone therapy. In this study recently published in the Journal of Clinical Endocrinology and Metabolism, the authors led by Hugh S. Taylor from the Department of Obstetrics, Gynecology and Reproductive Sciences from Yale…

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Programmed-cell death pathway and immune dysfunction in endometriosis

Programmed-cell death pathway and immune dysfunction in endometriosis By Irem Onur

Endometriosis is an estrogen-dependent, immune-associated disease. Women with endometriosis have different proportions of the activated forms of immunocompetent cells, such as T cells and macrophages compared to those from women without. Immune cell dysfunction in the uterine and abdominal cavity…

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Drugs targeting estrogen biosynthesis opening up new approaches to the treatment of endometriosis.

Drugs targeting estrogen biosynthesis opening up new approaches to the treatment of endometriosis. By Selma Oransay

Gibson et al., from the Univerity of Edinburgh, UK, take over a new interest about endometriosis occurrence and progress by endometrial tissue intracrinology in their recently online published article in International Journal of Molecular Sciences. The authors summarize the last…

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How to predict natural conception in women underwent endometriosis surgery?

How to predict natural conception in women underwent endometriosis surgery? By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The most common symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. The prevalence of endometriosis increases in the infertile population. Thus, the important…

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Preoperative Staging of Endometriosis: The Value of MRI After Dynamic Transvaginal Ultrasound

Preoperative Staging of Endometriosis: The Value of MRI After Dynamic Transvaginal Ultrasound By Irem Onur

Since endometriosis is a chronic and progressive disease, early diagnosis and proper staging are important for the patient and for the clinician to discuss and plan the required surgical procedures for treatment. Common diagnostic tools for pre-operative staging of deep…

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An overlooked symptom of endometriosis: Fatigue

An overlooked symptom of endometriosis: Fatigue By Timur Seckin

A majority of endometriosis patients experience fatigue. This is according to a multicenter study conducted by a group of researchers from Switzerland, Germany, and Austria. Fatigue, and feeling spoonie, may be a symptom of endometriosis affecting the daily activities and…

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The pain and its severity in deeply infiltrating endometriosis patients

The pain and its severity in deeply infiltrating endometriosis patients By Selma Oransay

Liang et al. from the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Sun Yat-sen University, China, recently published an interesting paper in the Journal of Pain Research, a prospective study to reveal the relationship between neurogenesis and other potential…

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Any adjustable risk factor for Endometriosis?

Any adjustable risk factor for Endometriosis? By Irem Onur

Endometriosis is believed to be estrogen and progesterone-dependent. Lifestyle factors such as alcohol/caffeine intake, smoking, and physical activity influence estrogen levels in the body and, therefore, may impact the development of endometriosis. In the study of Hemmert et al. which…

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Is Physical Exercise Effective in Endometriosis?

Is Physical Exercise Effective in Endometriosis? By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial tissue outside the uterine cavity. Dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility are mostly encountered symptoms of endometriosis. Although there are several theories explaining the pathogenesis of endometriosis, the exact pathogenesis still has…

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Does ovarian endometrioma damage the ovarian reserve?

Does ovarian endometrioma damage the ovarian reserve? By Dr. Youngran Park

Ovarian endometriomas are commonly present in 17% to 44% of women with endometriosis and are often associated with infertility and pelvic pain. There are several treatment options including surgical treatment. Cyst excision is associated with better results in terms of…

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The diagnosis and management of endometriosis in Korea

The diagnosis and management of endometriosis in Korea By Selma Oransay

The Korean Society of Endometriosis has scrutinized the present published literature of endometriosis in the domestic and international platform to provide new guidelines and the clinical management of the disease. The study was recently published in the journal "Obstetrics and Gynecology…

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A novel neurotransmitter, Ninj1, has been found to be expressed in endometriosis

A novel neurotransmitter, Ninj1, has been found to be expressed in endometriosis By Irem Onur

Chronic inflammation is involved in the pathogenesis of endometriosis and adenomyosis, and inflammatory cytokines such as IL-1b are highly expressed in them. Inflammation and subsequent hyperinnervation are involved in the pathophysiology of pain generation. High levels of expression of various…

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Can MRI be used to detect anterior pelvic endometriotic lesions?

Can MRI be used to detect anterior pelvic endometriotic lesions? By Hale Goksever Celik

Deep infiltrating endometriosis is the most severe manifestation of endometriosis. It is defined as the infiltration of ectopic endometrial tissue under the peritoneum, pelvic structures, and the organ walls such as the uterosacral ligaments, colon, vagina, bladder, ureter, rectovaginal septum,…

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Feasibility of MRI-Transvaginal Ultrasound Imaging for Deeply Infiltrating Endometriosis

Feasibility of MRI-Transvaginal Ultrasound Imaging for Deeply Infiltrating Endometriosis By Murat Osman

Endometriosis is a disease whereby endometrial tissue is present outside of endometrium. A specific form of endometriosis, Deeply Infiltrating Endometriosis (DIE), is characterized by endometriotic glands that invade through the endometrium and other structures in the pelvis and is associated…

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Does deep infiltrating endometriosis affect sexual activity?

Does deep infiltrating endometriosis affect sexual activity? By Dr. Youngran Park

Endometriosis is one of the most common gynecological diseases in women of reproductive age, and pelvic pain and infertility are the most frequent complications. There are three different type of endometriosis lesions; superficial lesions, deep lesions, and ovarian cysts. In…

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Autophagy, proteolysis and Endometriosis

Autophagy, proteolysis and Endometriosis By Kasthuri Nair

Sui et al., a group of researchers from the Qiqihar Medical University and Qilu Hospital of Shandong University, recently published in Experimental and Therapeutic Medicine. The piece titled “Expression and significance of autophagy genes LC3, Beclin1 and MMP-2 in endometriosis”…

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Best endometriosis articles of the past year.

Best endometriosis articles of the past year.  By Selma Oransay

Dr.Stowall, from the Department of Obstetrics and Gynecology of Methodist Hospital, Dallas, Texas, USA penned this letter and recently published it in the Journal of Obstetrics and Gynecology to show his remarks of importance on four best publications of the…

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Three dimensional sono-vaginography to diagnose rectovaginal endometriosis

Three dimensional sono-vaginography to diagnose rectovaginal endometriosis By Hale Goksever Celik

Deep infiltrating endometriosis is defined as the localization of ectopic endometrial tissue penetrating more than 5 mm into the affected pelvic organs. Rectovaginal endometriosis is the most severe form of deep infiltrating endometriosis in which ectopic endometrial tissue infiltrating rectum…

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Programmed cell death 4 suppresses endometriosis by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway

Programmed cell death 4 suppresses endometriosis by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway By Dr. Youngran Park

Endometriosis is a kind of benign disease but shares many similar features with cancers, such as abnormal cell migration, invasion, and unrestrained growth. It has been known that some genes are expressed differentially in eutopic endometrium of EM patients compared…

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Anatomic distribution of endometriosis

Anatomic distribution of endometriosis By Irem Onur

In the study of Audebert et al. which has been published in the journal European Journal of Obstetrics and Gynecology, the anatomic distribution of endometriosis, the rate of deep infiltrating endometriosis during the various study periods, laterality of endometriosis, pelvic…

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How Ovarian Endometriomas and DIE affect ART outcomes

How Ovarian Endometriomas and DIE affect ART outcomes By Murat Osman

Previous studies have evaluated the impact of an ovarian endometrioma on ovarian reserve and its impact on the success of assisted reproductive technology (ART) outcomes have controversial results.  ART is a method by which a woman’s own hormones are used…

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Suffering in Silence

Suffering in Silence By Deniz Kocas

Although quantitative and qualitative studies have established that endometriosis has a negative impact on multiple domains of quality of life, the majority of qualitative studies to date have used focus groups and interviews. These data collection methods may limit disclosure…

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Maternal and fetal outcomes in women with endometriosis : A review and meta-analysis

Maternal and fetal outcomes in women with endometriosis : A review and meta-analysis By Selma Oransay

Lalani et al from Dept. of Obstet. and Gynecol. , University of Ottowa, Canada, recently published this systemic review and meta-analysis of observational studies in the Journal of Human Reproduction, aimed to present the difference in the maternal and fetal…

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Could Endometriosis-Related Infertility Be Genetic?

Could Endometriosis-Related Infertility Be Genetic? By Özge Özkaya

Researchers identified genetic polymorphisms or individual differences in two genes called AMA5 and KAZN among women with endometriosis who were infertile and control women who were fertile. The identification of these polymorphisms could help scientists better understand why some women…

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Non-assisted reproductive technology treatment: Is it effective in infertile patients with advanced endometriosis?

Non-assisted reproductive technology treatment: Is it effective in infertile patients with advanced endometriosis? By Hale Goksever Celik

The marriage and childbearing ages delay due to the life-style changes in developed countries. As a result, advanced age becomes a major concern in infertility treatments which consist of non-ART and ART modalities. Non-ART treatments include mild ovarian stimulation together…

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IL-37 regulates ectopic endometrial stromal cells to prevent endometriosis

IL-37 regulates ectopic endometrial stromal cells to prevent endometriosis By Dr. Youngran Park

Endometriosis has been identified as a chronic inflammatory disease. It has been shown that in the plasma and peritoneal fluid, women with endometriosis exhibit aberrant numbers of immune cells and concentrations of cytokines and chemokines that promote a chronic inflammatory…

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PROPOFOL: a new combat for endometriosis?

PROPOFOL: a new combat for endometriosis? By Selma Oransay

Feng et al, from the Department of  Gynecology Weifang Medical University Hospital, Shandong, China, recently published their prospective experimental research in the journal Experimental and Therapeutic Medicine. Propofol, a rapid and short-term anesthetic substance, recently has been shown to prevent cancer through inhibiting…

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Parametrial endometriosis: A harder form of endometriosis

Parametrial endometriosis: A harder form of endometriosis By Hale Goksever Celik

Deep infiltrating endometriosis is the most severe manifestation of endometriosis, affecting 20% of all patients with endometriosis. It is defined as the infiltration of ectopic endometrial tissue under the peritoneum, pelvic structures, and the organ walls such as the uterosacral…

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Quality of life for women with endometriosis

Quality of life for women with endometriosis By Irem Onur

Endometriosis symptoms may cause difficulties in daily activities and social life, altering general health and personal relationships and severely decrease the quality of life. Yoldemir T. evaluates the factors affecting the quality of life in endometriosis patients and the management strategies in…

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Vitamin D and Endometriosis

Vitamin D and Endometriosis By Nasuhi Engin Aydin

Scientists from Milan, Italy reviewed the effects of vitamin D on the reproductive health, and in particular "endometriosis" in their article which appeared in International Journal of Molecular Sciences. Vitamin D (VD), is a steroid hormone that is activated in…

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Endometriosis involvement of the pouch of Douglas: TVUS vs pelvic exam

Endometriosis involvement of the pouch of Douglas: TVUS vs pelvic exam By Murat Osman

Deep infiltrating endometriosis (DIE) can lead to a partial or complete obliteration of the pouch of Douglas (POD). POD involvement has been associated with dyschezia, deep dyspareunia, and increased infertility rates. Assessing the extent of endometriosis involvement of the cul-de-sac allows…

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Will I Have Complications After Endometriosis Surgery?

Will I Have Complications After Endometriosis Surgery? By Özge Özkaya

The rate of complications after surgery to treat deep infiltrating endometriosis is low, confirmed a study by researchers in Germany. It is important to know whether major or minor complications following surgery are likely to develop and what the outcome…

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Inhibition of PI3K/AKT/mTOR pathway for the treatment of endometriosis.

Inhibition of PI3K/AKT/mTOR pathway for the treatment of endometriosis. By Dr. Youngran Park

Dr. Matsuzaki et al. (2018) published a paper entitled ‘In vitro and in vivo effects of MK2206 and chloroquine combination therapy on endometriosis’ showing that the efficacy of MK2206, an Akt inhibitor, in combination with chloroquine for inducing autophagy in…

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Laparoscopic surgery of endometriosis through three compartments

Laparoscopic surgery of endometriosis through three compartments By Selma Oransay

This case study which is published in the J. of Minimally İnvasive Gynecology is the video demonstration of Collin et al who performed the laparoscopic operation of their patient in Gynecologic Surgery Department of Strasburg Hospital University, France. 37 years old…

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How to preserve fertility in women with “ovarian endometriosis”?

How to preserve fertility in women with “ovarian endometriosis”? By Hale Goksever Celik

Although there are many treatment modalities in endometriosis, optimal treatment has not been developed yet. The aim of the treatment is to reduce pain, to preserve and improve fertility and to delay recurrence. Ovarian ischemic and perfusion damage during endometriosis…

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Multimodality imaging and clinicopathologic assessment of abdominal wall endometriosis

Multimodality imaging and clinicopathologic assessment of abdominal wall endometriosis By Irem Onur

Abdominal wall endometriosis is a rare clinical entity frequently diagnosed with a significant delay and easily misinterpreted despite multimodality imaging. In the study of Jaramillo-Cardoso et al. which has recently been published in the journal Abdominal Radiology, the clinical, multimodality…

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MTA1 as a predictor for the progression of endometriosis.

MTA1 as a predictor for the progression of endometriosis. By Selma Oransay

Jing Zhang et al. from the Department of Obstetrics and Gynecology, Affiliated Haikou Hospital, Xiangya Medical College of Central South University, Hainan, China, published their article in the open access medical journal "Medicine". Their aim was to evaluate the relationship between…

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A rare location of endometriosis: Perineum

A rare location of endometriosis: Perineum By Timur Seckin

A rare case of perineal endometriosis is reported by Dr. Ravikant, from India, and has been recently published in the "Journal of Medical Ultrasound".  The patient, a 28-year-old woman with one living child, presented with a 6-month history of a…

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Shedding light on the fertility preservation debate in women with endometriosis: a swot analysis.

Shedding light on the fertility preservation debate in women with endometriosis: a swot analysis. By Deniz Kocas

There is little known about fertility preservation in women with endometriosis. Researchers from France and Switzerland conducted a SWOT (strengths, weaknesses, opportunities, and threats) analysis to better understand this topic. Applied to clinical problems, SWOT gives a thorough analysis of…

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Fighting with endometriosis

Fighting with endometriosis By Irem Onur

Maduro M.R. reviewed three separate studies on potential new targets to successfully manage endometriosis in her recent paper titled “Novel Strategies to Fight Endometriosis” published in the journal Reproductive Sciences. In the autotransplantation rat model of Torres-Reveron et al., the…

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Cosmetics and some household products could be responsible for worsening endometriosis.

Cosmetics and some household products could be responsible for worsening endometriosis. By Selma Oransay

A controlled clinical study recently published in the Journal of Human Reproductive Sciences,  composed by Nazir et al. from the University of Health Sciences, Lahore, Pakistan. The study compared the blood diethyl hexyl phthalate (DEHP) levels of fifty infertile women laparoscopically diagnosed…

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Transvaginal ultrasound for "rectosigmoid endometriosis" diagnosis: Is bowel preparation necessary?

Transvaginal ultrasound for By Hale Goksever Celik

Rectosigmoid endometriosis is a severe form of deep endometriosis. Women having rectosigmoid endometriosis present with pain and several intestinal complains such as constipation, diarrhea, intestinal cramping, abdominal bloating, feeling of incomplete evacuation, the passage of mucus and rectal bleeding during…

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Toxic Pelvic Cavity and Infertility

Toxic Pelvic Cavity and Infertility By Murat Osman

Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterine cavity and has an incidence of approximately 10% in women of reproductive age. Thus, it is an important consideration in chronic pelvic pain and infertility…

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Reduced pain and increased fertiliy rates after surgery for colorectal endometriosis

Reduced pain and increased fertiliy rates after surgery for colorectal endometriosis By Selma Oransay

This prospective cohort study which recently published in AOGS by Hudelist et al. from Oslo University, Norway is about their one hundred thirty-four laparoscopic operations of DIE cases performed between 2011 and  2016, in a tertiary center in Oslo. The…

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IVF Is the Best Option to Become Pregnant for Women with Severe Endometriosis, or Is It Not?

IVF Is the Best Option to Become Pregnant for Women with Severe Endometriosis, or Is It Not? By Özge Özkaya

Treating rectal endometriosis with surgery seems to increase the chance of a woman conceiving, with most pregnancies occurring naturally. This is according to a study published in the medical journal Human Reproduction.  The optimal treatment for women with severe endometriosis…

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Endometrioma and endometriosis

Endometrioma and endometriosis By Irem Onur

Exacoustos C. et al. published an article titled “The isolated ovarian endometrioma: a history between myth and reality” in the Journal of Minimally Invasive Gynecology in 2018. They aimed to examine the association between ovarian endometriomas detectable at the transvaginal ultrasound…

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How to evaluate ureteral endometriosis : A review of the literature

How to evaluate ureteral endometriosis :  A review of the  literature By Selma Oransay

In this recently published review of the literature, Barra et al. from Genova, Italy intend to provide a useful tool to guide physicians in the management of deep infiltrating endometriosis. Authors elected 67 abstracts from Pubmed and Medline in accordance with PRISMA…

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Comorbidity Risks Among Women with Endometriosis

Comorbidity Risks Among Women with Endometriosis By Deniz Kocas

Evidence demonstrates that endometriosis is associated with higher rates of conditions such as ovarian and other gynecological cancers, thyroid cancer, autoimmune diseases, asthma/atopic diseases, and cardiovascular diseases. However, as findings remain fragmented, there is a need to assess these associations…

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Endometriosis in adolescents

Endometriosis in adolescents By Irem Onur

Dr. Mama S. T. from Cooper University Hospital, Camden, New Jersey, USA, recently has published his review on advances in the management of endometriosis in the adolescent in the journal “Current Opinion Obstetrics and Gynecology”. In adolescence, there is a…

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A Better Way to Diagnose Endometriosis?

A Better Way to Diagnose Endometriosis? By Özge Özkaya

Three proteins found in the blood and endometrial tissues could be used to determine the stage of endometriosis and the severity of painful periods according to a study published in the journal Current Medical Science. Evaluating the levels of these…

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Pain and emotion regulation predict health-related quality of life

Pain and emotion regulation predict health-related quality of life By Deniz Kocas

Studies have established that pain in endometriosis is negatively correlated with HRQL and that endometriosis is associated with psychological problems, anxiety, depression, distress and poor coping ability. It has been observed that some mental conditions associated with endometriosis are modulated…

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Endometriosis as a chronic disease: The benefits for the patients

Endometriosis as a chronic disease: The benefits for the patients By Selma Oransay

Rebecca O'Hara et al. from Monash University, Melbourne, Australia, recently published their qualitative case study in the Journal "Australian Health Review", to build a National Policy about endometriosis considering as a chronic disease.    In Australia, long-term complex diseases are managed…

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How are endometriosis patients managed clinically?

How are endometriosis patients managed clinically? By Irem Onur

This review paper by Falcone and Flyckt, entitled “Clinical Management of Endometriosis” published in the journal Obstetrics & Gynecology aims to summarize the current strategies for treating endometriosis patients with pain, pelvic dysfunction, and subfertility related to their disease. There are many…

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FDA Approves Endometriosis Pain Treatment

FDA Approves Endometriosis Pain Treatment By Özge Özkaya

The U.S. Food and Drug Administration (FDA) approved a new medication for the treatment of moderate to severe pain associated with endometriosis, making it the first treatment to be approved in 10 years. The decision was announced in the Journal…

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A Balancing Act: How Endometriosis Invades the Body

A Balancing Act: How Endometriosis Invades the Body By Murat Osman

Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterine cavity. Ectopic endometrial tissues have been shown to have some features that mimic malignancy. For example, endometriosis can invade surrounding structures and attach to surfaces such…

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A Tool That Goes Where No One Has Gone Before

A Tool That Goes Where No One Has Gone Before By Kasthuri Nair

Vitral et al., researchers from the Federal University of Juiz de Fora, recently published a paper in the World Journal of Nuclear Medicine titled “Use of radioguided surgery in abdominal wall endometriosis: An innovative approach.” The publication focused on a…

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Should I Have Surgery Before Trying to Conceive?

Should I Have Surgery Before Trying to Conceive? By Özge Özkaya

The presence of rectouterine nodules is associated with a lower chance of becoming pregnant with in vitro fertilization (IVF), according to a study published in the Journal of Gynecology Obstetrics and Human Reproduction. This finding is important as it can…

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The vaginal delivery rate of singleton term pregnancies still remains the same after total deep infiltrating endometrosis excisions

The vaginal delivery rate of singleton term pregnancies still remains the same after total deep infiltrating endometrosis excisions By Selma Oransay

This recently published report in the Journal of Fertility Sterility is planned as a  matched case-control study, by Nirgianakanis et al. from the University of Bern, Switzerland. Authors claimed their study is the first because previous studies on pregnancy outcome after laparoscopic…

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Prior endometriosis surgery and the risk of pregnancy complications

Prior endometriosis surgery and the risk of pregnancy complications By Irem Onur

Koninckx et al. discussed the association of pregnancy complications with endometriosis and endometriosis surgery in their recently published paper in the journal Fertility and Sterility. They especially mentioned about the retrospective study of Nirgianakis et al. published in the same…

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Women recommended laparoscopy for chronic pelvic pain

Women recommended laparoscopy for chronic pelvic pain By Irem Onur

Chronic pelvic pain is a diagnostic and therapeutic dilemma. It has many etiologies in many organ systems. Clinician and patient factors affect the management of chronic pelvic pain. Mirowska-Allen K.L. et al. have recently published an article titled, “The characteristics of…

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Vitamin C supplementation in the patients with endometriosis undergoing in vitro fertilization-embryo transfer

Vitamin C supplementation in the patients with endometriosis undergoing in vitro fertilization-embryo transfer By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Women having endometriosis present with dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Thus, infertility remains a significant problem for women with endometriosis. Endometriosis is…

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Questionnaire based evaluation of sexual life after laparoscopic surgery for endometriosis

Questionnaire based evaluation of sexual life after laparoscopic surgery for endometriosis By Deniz Kocas

Researchers from Denmark note that laparoscopic surgery is being increasingly used for the treatment of endometriosis due to its safety and effectiveness. However, treatment success is often evaluated through follow-up on the experience of pain, leaving other important aspects of…

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Complementary treatments for endometriosis symptoms: acupuncture, exercise, electrotherapy, or yoga?

Complementary treatments for endometriosis symptoms: acupuncture, exercise, electrotherapy, or yoga? By Yu Yu

Endometriosis is associated with debilitating symptoms in some women including dysmenorrhea, chronic pelvic pain, deep dyspareunia, dyschezia, and dysuria. There are a few therapeutic options to treat these symptoms; however, only a few studies have considered treating the pain symptoms…

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Coumarin based compounds found to inhibit the estradiol synthesis pathway

Coumarin based compounds found to inhibit the estradiol synthesis pathway By Murat Osman

Endometriosis is a disease characterized by ectopic endometrial tissue outside the endometrium. Several biochemical and molecular pathways have been researched and used to alleviate endometriosis symptoms by inhibiting key molecules involved in the menstrual cycle. This review paper by Niinivehmas…

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The diagnostic value of “sliding sign” and direct visualization of the bowel in rectal/rectosigmoid deep endometriosis

The diagnostic value of “sliding sign” and direct visualization of the bowel in rectal/rectosigmoid deep endometriosis By Hale Goksever Celik

Deep endometriosis is the presence of endometrial subperitoneal implants of ≥5 mm localized in the rectum/rectosigmoid bowel, uterosacral ligaments, rectovaginal septum, vagina and/or bladder. The most common diagnostic screening methods are the transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI)…

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Is there a new hope for the prevention of endometriotic invasions?

Is there a new hope for the prevention of endometriotic invasions? By Selma Oransay

This research which recently published in Biomed Research International is performed by Xiaomei et al. from Obst/Gyn, Pathology and Genetic departments of three hospitals in Changsha, CHINA. The authors planned a prospective and controlled biochemical study to specify the role…

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Fluorescence Guided Surgery: a New Technique to Treat Deep Infiltrating Endometriosis

Fluorescence Guided Surgery: a New Technique to Treat Deep Infiltrating Endometriosis By Özge Özkaya

Fluorescence-guided surgery could help differentiate recto-vaginal deep infiltrating endometriosis nodules (RVDIEN) from healthy rectal tissue and remove them successfully without perforating the rectum, according to a study published in the scientific journal Surgical Innovation.  The method could offer a better,…

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The role of peritoneal washings in the diagnosis of endometriosis

The role of peritoneal washings in the diagnosis of endometriosis By Irem Onur

Endometriosis is a common entity seen in the gynecologic tract and pelvic surfaces. It may be frequently asymptomatic and/or undiagnosed at the time of gynecologic surgery. Pathologists diagnose endometriosis based on the presence of at least two of the following elements: endometrial glands,…

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“Free butterflies will come out of these deep wounds”: A grounded theory of how endometriosis affects women’s psychological health

“Free butterflies will come out of these deep wounds”: A grounded theory of how endometriosis affects women’s psychological health By Deniz Kocas

Researchers from the Catholic University of Milan and the University of Milan note in Journal of Health Psychology that although qualitative research describes the negative impact of endometriosis on quality of life and psychological well-being, studies that analyze individual differences…

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How to improve the current ASRM classification of endometriosis?

How to improve the current ASRM classification of endometriosis? By Selma Oransay

In this article which recently published in Best Practice&Research Clinical Obst&Gyn.  from the University of Sao Paulo, Brazil, Andres et al.  penned a review of the classification of endometriosis in chronological order, and discussed the limitations of existing classification systems to…

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CARD10 and CARD11 Mutations: Another Piece of the Puzzle

CARD10 and CARD11 Mutations: Another Piece of the Puzzle By Kasthuri Nair

Zou et al., a research group from China, recently published a study titled “Analysis of CARD10 and CARD11 somatic mutations in patients with ovarian endometriosis” in Oncology Letters. The paper looked at the effects of caspase recruitment domain family member…

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Oxidative Stress and Endometriosis

Oxidative Stress and Endometriosis By Murat Osman

Endometriosis is a disease characterized by ectopic endometrial tissue outside the endometrium and is associated with a background of a chronic inflammation. Recent studies have aimed to elucidate the inflammatory mediators involved in endometriotic lesions by studying immune cell interactions,…

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3,6-DHF suppresses the invasive properties of endometrial stromal cells through the Notch signaling

3,6-DHF suppresses the invasive properties of endometrial stromal cells through the Notch signaling By Dr. Youngran Park

Dr. Zhou group reported recently that 3,6-DHF can inhibit the development of EMT, migration, and invasion of endometrial stromal cells by inhibiting the Notch signaling pathway. Endometriosis is a condition in which the layer of tissue (glands and mesenchyme) that normally…

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Impact of coping strategies on quality of life of adolescents and young women with endometriosis.

Impact of coping strategies on quality of life of adolescents and young women with endometriosis. By Deniz Kocas

González-Echevarría et al. report in J Psychosom Obstet Gynaecol. that symptoms caused by endometriosis have been found to be associated with negative quality of life (QoL) in women with endometriosis and the type of coping strategies adopted by patients have been shown…

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Can we predict the complexity of laparoscopic surgery by ultrasound?

Can we predict the complexity of laparoscopic surgery by ultrasound? By Selma Oransay

This is a multicentric, retrospective cohort study recently published in the Journal of Minimally Invasive Gynecology by Tompsett et al. in which the results of the transvaginal ultrasonographic examinations (TVS) are compared to the results of the laparoscopic operations performed…

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Health-related quality of life in women with Endometriosis and Rheumatoid Arthritis

Health-related quality of life in women with Endometriosis and Rheumatoid Arthritis By Murat Osman

Endometriosis is a chronic inflammatory disease that is defined by the presence of ectopic endometrial tissue outside of the uterus. Unfortunately, endometriosis continues to be a leading cause of chronic pelvic pain and long-term morbidity in women of reproductive age.…

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Thoracic Endometriosis Syndrome (TES): Diagnosis by cytology of pleural effusion

Thoracic Endometriosis Syndrome (TES): Diagnosis by cytology of pleural effusion By Nasuhi Engin Aydin

Parikshaa Gupta and colleagues from Chandigarh, India report a case of thoracic endometriosis diagnosed primarily by pleural fluid cytology in a most recent article at Cytopathology. A 33-year-old female presented with a long history of recurrent bouts of chest pain…

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Endometriosis Development: Pathogenesis and genomics

Endometriosis Development: Pathogenesis and genomics By Selma Oransay

In this review recently published in the International Journal of Molecular Sciences, Baranow et al from Saint Petersburg, Russia,  hypothesize the existence of an endometriosis development genetic program (EMDP) that governs the origin of endometrium stem cells programmed for endometriosis; their transition…

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The association between endometriosis, adenomyosis and preterm delivery

The association between endometriosis, adenomyosis and preterm delivery By Hale Goksever Celik

Endometriosis and adenomyosis are diseases of the same spectrum which have common features and coexist in some but not all patients. Both diseases are characterized by endometrial implants outside of the uterine cavity. Endometriosis is defined as the localization of…

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Polymorphism of IL12B May Help Solve Endometriosis

Polymorphism of IL12B May Help Solve Endometriosis By Kasthuri Nair

Zhao et al. recently published a paper titled “A functional promoter polymorphism in interleukin 12B gene is associated with an increased risk of ovarian endometriosis” in Gene. The research group from Hebei Medical University wanted to explore the potential roles…

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A Doctor's Guide to Making Endometriosis Less Scary

A Doctor's Guide to Making Endometriosis Less Scary By Kasthuri Nair

Canis, Bourdel, and Chauvet, doctors from CHU Estaing, recently published an article titled “Endometriosis: frightening the patients is not an acceptable alternative to inadequate surgical management and or pathophysiology ignorance” in Fertility and Sterility. Their paper delineated proper health practices…

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Personalised Medicine for Endometriosis?

Personalised Medicine for Endometriosis? By Özge Özkaya

The lining of the uterus of women with endometriosis is different from that of women without the disease even if they have chronic pelvic pain found a study published in the scientific journal Biology of Reproduction. The difference is found…

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Is there a definitive guideline for the surgical management of endometriosis?

Is there a definitive guideline for the surgical management of endometriosis? By Murat Osman

Endometriosis is a chronic inflammatory disease that is defined by the presence of ectopic endometrial tissue outside of the uterus. Unfortunately, endometriosis continues to be a leading cause of chronic pelvic pain in women of reproductive age. This article titled,…

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Predictors of psychological distress

Predictors of psychological distress By Deniz Kocas

Studies have now established that endometriosis can negatively impact mental health and quality of life, however, some studies show that not all women with endometriosis are necessarily more distressed than healthy women. This suggests that individual differences may explain women’s’…

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Key to Understanding Ovarian Endometriosis may lay in the Peptides

Key to Understanding Ovarian Endometriosis may lay in the Peptides By Kasthuri Nair

Xue et al. recently published a paper titled “Peptidomic Analysis of Endometrial Tissue from Patients with Ovarian Endometriosis” in Cellular Physiology and Biochemistry. The research group from various departments of Nanjing Medical University wished to better understand the pathogenesis of…

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How do adolescent girls and boys perceive symptoms suggestive of endometriosis among their peers?

How do adolescent girls and boys perceive symptoms suggestive of endometriosis among their peers? By Dr. Youngran Park

Endometriosis, a chronic condition characterized by cells similar to the uterine lining that exist outside of the uterus, is estimated to impact 10% of women of reproductive age. In the USA, that approximates to some 7.4 million women. Endometriosis has…

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Inflammatory molecules promote the migration and invasion of endometriosis cells

Inflammatory molecules promote the migration and invasion of endometriosis cells By Yu Yu

Increasing scientific evidence has shown that the immune and inflammatory mechanisms play a central role in the progression of endometriosis by allowing a permissive environment that allows migration, adhesion, proliferation, and invasion of endometrial cells in ectopic regions of the…

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What is being done to help surgeons detect endometriosis during laparoscopy

What is being done to help surgeons detect endometriosis during laparoscopy By Murat Osman

The gold standard for the diagnosis of endometriosis is diagnostic laparoscopy and histologic confirmation. During laparoscopy, visualization of as many lesions as possible may hold better long-term clinical outcomes. Peritoneal endometriosis is difficult to diagnose intraoperatively due to the heterogeneity…

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