Abdominal wall endometriosis is not a rare disease as supposed

Abdominal wall endometriosis is not a rare disease as supposed By Hale Goksever Celik

Abdominal wall endometriosis is an iatrogenic type of endometriosis defined as the localization of endometrial glandular and stromal tissue on the abdominal wall including skin, the rectus abdominis muscle, and rectus muscle sheath. Cyclical pain, mass located on the abdominal…

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The incidence of ovarian cancer after histologically diagnosed endometriosis.

The incidence of ovarian cancer after histologically diagnosed endometriosis. By Selma Oransay

Ovarian cancer has the highest mortality rate among gynecologic cancers. Furthermore, these patients are generally diagnosed in advanced stage due to their non-symptomatic nature. Therefore, preventative strategies have enormous importance for the management of ovarian cancer.  Dr. Hermens and colleagues…

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How reliable are the patient questionnaires in predicting endometriosis?

How reliable are the patient questionnaires in predicting endometriosis? By Eylül GÜN

It is well known that the diagnosis of endometriosis is delayed in the majority of patients throughout the world. The burden that this brings has many effects on the patients’ lives as well as the society. The radiological developments in…

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Distribution of tubal endometriosis

Distribution of tubal endometriosis By Selma Oransay

The incidence of tubal endometriosis was previously reported in a percentage of 4 to 11, but recent studies gave a prevalence up to 42.5 % which indicates the actual incidence of this disease is underestimated.  Some studies in recent literature…

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A novel contribution to patient management in endometriosis by immunohistochemistry

A novel contribution to patient management in endometriosis by immunohistochemistry By Nasuhi Engin Aydin

Dr. Tarumi and associates from the Kyoto Prefectural University of Medicine, Kyoto, Japan published their retrospective cohort study on the importance of progesterone receptors on recurring ovarian endometriosis in "The Journal of Clinical Endocrinology & Metabolism". Surgery for endometriosis is…

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 Which of the suggested environmental risk factors are indeed related to endometriosis?

 Which of the suggested environmental risk factors are indeed related to endometriosis? By Eylül GÜN

Endometriosis is a complex disease with genetic and environmental factors in its poorly understood pathogenesis. Even though many epidemiological studies in the literature have proposed several risk factors, the lack of clear establishment and modification of these potential risk factors…

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Listening to patients’ complaints is the first step on the way to a diagnosis of endometriosis.

Listening to patients’ complaints is the first step on the way to a diagnosis of endometriosis. By Hale Goksever Celik

Early diagnosis and management of endometriosis are not possible due to the wide spectrum of symptoms and absence of non-invasive diagnostic biomarkers. Particularly the adolescent population is at risk for the diagnostic delay because pelvic pain and dysmenorrhea are very…

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Are the studies based on the nationwide databases more accurate?

Are the studies based on the nationwide databases more accurate? By Eylül GÜN

One of the most common localizations of endometriosis is the ovaries, and therefore, ovarian endometriomas are among the most surgically treated endometriotic lesions. Dr. Roman from Denmark has recently written an editorial about the surgical interventions on ovarian endometrioma and…

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Endometriosis diagnosis and management based on the best available evidence from published literature

Endometriosis diagnosis and management based on the best available evidence from published literature By Selma Oransay

ESHRE, "European Society of Human Reproduction and Embryology" published a Guideline for the diagnosis and treatment of endometriosis in 2005 and then revised it in 2013. Based on new research and development there was a need to renew the last…

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Medicinal Cannabis Use for Endometriosis in Australia and New Zeland

Medicinal Cannabis Use for Endometriosis in Australia and New Zeland By Özge Özkaya

Cannabis use leads to positive outcomes for the management of endometriosis according to the results of an online survey among patients from Australia and New Zealand. These findings, which were published in the journal Cannabis and Cannabinoid Research suggest that…

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Endometriosis information coming from the social media

Endometriosis information coming from the social media   	By Bahar Yuksel

Today’s changing and evaluating world led everything to be lived online. For sure endometriosis and searching for cures or support for endometriosis have been transferred to online social media platforms too. The study conducted by Julian Matthias Metzler et al…

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What are the most common symptoms of endometriosis and how are they related to age?

What are the most common symptoms of endometriosis and how are they related to age? By Eylül GÜN

Even though the incidence of endometriosis is relatively high and numerous studies are being conducted to elucidate its pathogenesis, it is still a highly underdiagnosed and undertreated disease. The symptoms of the disease are well-known; however, the correlation between the…

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A revolutionary view on endometriosis related pain

A revolutionary view on endometriosis related pain By Nasuhi Engin Aydin

Dr. Lydia Coxon and colleagues from Oxford University, UK, have recently published their cross-sectional study on the categorization of endometriosis-related pain in the journal "Frontiers in Pain Research". As a chronic inflammatory condition, endometriosis results in pelvic pain, dysmenorrhea, and…

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Prevalence of endometriosis and adenomyosis by transvaginal ultrasound.

Prevalence of endometriosis and adenomyosis by transvaginal ultrasound. By Selma Oransay

Women who present dyspareunia, dysmenorrhea, dysuria, dyschezia, chronic abdominal, and pelvic pain, and infertility would benefit from the early investigation. If the correct diagnosis of endometriosis and/or adenomyosis can be made in advance, early treatment will improve the quality of…

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Mindfullness Can Hep Reduce Endometriosis Pain

Mindfullness Can Hep Reduce Endometriosis Pain By Özge Özkaya

A brief mindfulness-based intervention can be useful in managing pain related to endometriosis and restoring patients’ psychological well-being, found a new study published in the European Journal of Pain. This finding contributes to the applicability of mindfulness-based interventions in people…

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Planning surgery for recto-sigmoid endometriosis with 3D virtual models.

Planning surgery for recto-sigmoid endometriosis with 3D virtual models. By Selma Oransay

Efforts to reduce the high complication rate of rectosigmoid surgery in deeply infiltrated endometriosis are of great interest to gynecologists. 3D printing, currently used in various surgical specialties to support surgical planning and guide intraoperative procedures may be a way…

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Non-invasive diagnostic tools for endometriosis revisited

Non-invasive diagnostic tools for endometriosis revisited By Nasuhi Engin Aydin

Dr. Signorile and associates from the Italian Endometriosis Foundation have published the results of their retrospective study on a large cohort of endometriosis patients in a recent issue of the periodical, In Vivo. Endometriosis lacks precise scientific knowledge and this brings…

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The underlying reason of implantation failure in women with endometriosis-associated infertility

The underlying reason of implantation failure in women with endometriosis-associated infertility By Hale Goksever Celik

Endometriosis is most frequently encountered in reproductive-aged women, with a prevalence of 10-15% in the general population. However, endometriosis is more frequently diagnosed in infertile women, with a prevalence of 25-40%. Although the exact mechanism explaining the association between endometriosis…

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Cannabis use in the management of endometriosis-related pain during the COVID19 pandemic

Cannabis use in the management of endometriosis-related pain during the COVID19 pandemic By Eylül GÜN

Pain management in endometriosis has been challenging owing to many reasons. Since the pathways that cause pain in endometriosis have not been elucidated extensively, the medical and surgical management of pain remains to be symptomatic. Alternative pain management methods have…

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Prolactin receptor antibodies: A novel treatment proposal for endometriosis

Prolactin receptor antibodies: A novel treatment proposal for endometriosis By Eylül GÜN

Prolactin, a hormone that also acts as a proinflammatory cytokine through its receptor PRLR has been shown to be involved in endometriosis pathogenesis. Previous studies reported that women suffering from endometriosis had elevated prolactin levels. Also, in experimental studies done…

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A French National Study Concerning The "Recovery Protocol" After Deep Infiltrating Endometriosis Surgery.

A French National Study Concerning The By Selma Oransay

In recent years especially for complex surgeries, enhanced recovery after surgery (ERAS) programs have been implemented in several surgical specialties. This is based on a multimodal and multidisciplinary approach centered on the patient’s perioperative situation designed to improve patient management and reduce…

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International Working Group's review on endometriosis classification systems

International Working Group's review on endometriosis classification systems By Nasuhi Engin Aydin

International Endometriosis Working Group including AAGL, ESHRE, ESGE, and WES published a comprehensive review on endometriosis classification, staging, and reporting systems in a recent issue of the journal named "Facts, Views & Vision in Obstetrics and Gynecology". Classification and staging…

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Imaging Techniques Able to Predict Depth of Endometriosis Before Surgery

Imaging Techniques Able to Predict Depth of Endometriosis Before Surgery By Özge Özkaya

Transvaginal ultrasound (TVUS) and pelvic magnetic resonance imaging (MRI) performed by a specialist can accurately predict the depth of rectosigmoid endometriosis before surgery, according to a new study published in the Journal of Minimally Invasive Gynecology. Both approaches are similar…

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A novel scoring tool to standardize surgical complexity for gynecologists.

A novel scoring tool to standardize surgical complexity for gynecologists. By Selma Oransay

The field of gynecologic surgery needs a more comprehensive, objective, and reproducible method for assessing and communicating surgical complexity than the current approach. Actually, there is no formal image-based system that allows surgeons to categorize and communicate the complexity of…

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An important enigmatic promoter of endometriosis: immune dendritic cells

An important enigmatic promoter of endometriosis: immune dendritic cells By Nasuhi Engin Aydin

Dr. Larinha and associates from a Brasilian academic center have published their comprehensive review on the role of immune dendritic cells in the pathogenesis of endometriosis in a recent issue of the "Journal of Reproductive Immunology". Antigen-presenting dendritic cells of…

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A quick insight into the latest research on endometriosis diagnosis and management

A quick insight into the latest research on endometriosis diagnosis and management By Eylül GÜN

Endometriosis research has been expanding with many new studies ranging from new techniques and markers in diagnosis to updates in clinical management and treatment of the disease. The journal Frontiers in Surgery recently brought together articles that reflect important and…

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Immunotherapy in endometriosis: a challenging research topic

Immunotherapy in endometriosis: a challenging research topic By Nasuhi Engin Aydin

Dr. Maksym and associates from academic centers in Poland have published their comprehensive review on endometriosis emphasizing the immunological aspects of the disease in a recent issue of the "Journal of Clinical Medicine". Even though endometriosis is a multifactorial disease,…

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Algorithm for pain management in endometriosis

Algorithm for pain management in endometriosis By Selma Oransay

One of the debilitating symptoms of endometriosis is pain. Mostly due to delayed diagnosis and the high recurrence rate, even after the surgical and hormonal therapy pain control may not be sufficient causing the patient to suffer for decades.  Endometriosis-associated…

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A New Non-Invasive Marker for Endometriosis?

A New Non-Invasive Marker for Endometriosis? By Özge Özkaya

The reactivity of serum immunoglobulin G (IgG) with fucose-specific lectins AAL, LCA, and LTA could be a useful diagnostic biomarker for endometriosis, according to a new study published in the Journal of Inflammation Research. It could also be a clinical…

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Is "non-hormonal therapy" effective in women with endometriosis-associated pain?

Is By Hale Goksever Celik

Women with endometriosis require effective treatment due to the negative impact of the disease on quality of life. Hormonal treatments including oral contraceptives, and progestins are usually recommended to suppress ovulation and decrease pelvic pain. However, some women do not…

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Risk of cardiovascular disease in endometriosis patients

Risk of cardiovascular disease in endometriosis patients By Eylül GÜN

A well-known fact about endometriosis is the inflammatory processes that underlie its pathophysiology. The inflammatory markers have been thought to play a role in many additional disorders in endometriosis patients. One of the primary markers of inflammation is C-reactive protein…

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The consequences of endometriosis on the quality of life

The consequences of endometriosis on the quality of life By Hale Goksever Celik

The most common clinical findings of endometriosis patients are pelvic pain and fertility problems, resulting in impairment of quality of life. These women are affected especially during the menstruation period. Olliges et al., from Germany and Switzerland, published a study…

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Surgery for the Treatment of Endometriosis of the Diaphragm and Thorax

Surgery for the Treatment of Endometriosis of the Diaphragm and Thorax By Özge Özkaya

Diaphragmatic and thoracic endometriosis starts in the abdominal wall of the diaphragm and later invades the thorax, based on findings from a series of patients surgically treated for the disease, reports a study published in the Journal of Gynecology Obstetrics…

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Diaphragmatic defects, liver herniations and catamenial pneumothorax

Diaphragmatic defects, liver herniations and catamenial pneumothorax By Nasuhi Engin Aydin

Dr. Arakawa and associates from The Jikei Katsushika Medical Center, Japan, have published their recent case of catamenial pneumothorax with diaphragmatic defect and liver herniation in the "Journal of Cardiothoracic Surgery". Catamenial pneumothorax is an uncommon condition with a reported…

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Endometriosis of the Diaphragm, What do the Doctors Know About it?

Endometriosis of the Diaphragm, What do the Doctors Know About it? By Özge Özkaya

The median time between the first consultation with a primary care physician and receiving a diagnosis of endometriosis of the diaphragm is two years according to a study by U.K. researchers. In the worse case, it took 23 years for…

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The largest series of diaphragmatic endometriosis

The largest series of diaphragmatic endometriosis By Bahar Yuksel

Diaphragmatic endometriosis is one of the most common extra pelvic endometriosis types, yet the correct incidence is unclear. In the study conducted by Ceccaroni Marcello et al from the International School of Surgical Anatomy, Verona, Italy, the authors analyzed the…

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Diaphragmatic endometriosis

Diaphragmatic endometriosis By Selma Oransay

Diaphragmatic endometriosis is a rare clinical condition that may show signs and symptoms like chest pain, right upper quadrant abdominal pain, shoulder pain, pleuritic pain, hemothorax, pneumothorax, hemoptysis, and thoracic endometriosis syndrome while the major part of the patients is…

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Thoracic endometriosis: the most frequent endometriosis involvement outside abdominopelvic cavity

Thoracic endometriosis: the most frequent endometriosis involvement outside abdominopelvic cavity By Nasuhi Engin Aydin

Six to ten percent of reproductive-age women are affected by endometriosis, and about 12% are estimated to be outside the abdominopelvic cavity - the most frequent location being the thorax. Endometriosis within the pulmonary parenchyma or on the diaphragm and…

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Urinary Tract Endometriosis

Urinary Tract Endometriosis By Bahar Yuksel

Endometriosis is mostly seen in patients of fertile age, and urinary tract endometriosis affects 1.2 to 6% of women with endometriosis. French coloRectal Infiltrating ENDometriosis Study (FRIENDS) group investigated the characteristics of urinary tract endometriosis in 232 patients from 31 centers. Authors…

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Which surgical technique is best for rectal endometriosis?

Which surgical technique is best for rectal endometriosis? By Eylül GÜN

One of the common sites for deep endometriosis is the intestines, with a rate of 3-37%. Intestinal endometriosis constitutes a serious cause of gastrointestinal symptoms, pain, and the alteration of the quality of life, with the rectum and sigmoid colon being…

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Nerve-sparing technique for deep infiltrating endometriosis and its impacts on pelvic organ and sexual functions.

 Nerve-sparing technique for deep infiltrating endometriosis and its impacts on pelvic organ and sexual functions. By Selma Oransay

Deep infiltrating endometriosis and involvement of parametrium cause severe pelvic pain and dysfunction of some pelvic organs resulting in a reduction in women's quality of life. Although surgery for DIE aims to relieve pelvic pain, entering into the posterior parametrial…

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Effects of Bowel Endometriosis Surgery on Mode of Delivery

Effects of Bowel Endometriosis Surgery on Mode of Delivery By Özge Özkaya

Less than a third of doctors counsel women about the possible effects of surgical treatment of bowel endometriosis on their mode of delivery should they become pregnant, according to a new study published in the Journal of Obstetrics and Gynaecology.…

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A comparison of endometriosis Classifications: rASRM, EFI or Enzian?

A comparison of endometriosis Classifications: rASRM, EFI or Enzian? By Selma Oransay

None of the endometriosis classifications provide a clinically valuable system since the very first description of the disease in 1860. One unique terminology to describe the localization and the extension of the disease is needed, which should be the same…

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Egg or chicken, which is causing bladder symptoms, DIE or surgery for DIE?

Egg or chicken, which is causing bladder symptoms, DIE or surgery for DIE? By Bahar Yuksel

Urinary symptoms could be overwhelming and sometimes could be hidden behind pain symptoms, but still might cause secondary damages on kidneys and bladder if remain undetected. In the prospective study conducted by Laterza et al, the authors questioned whether the…

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Surgery before in-vitro fertilization – Is it beneficial in patients with deep endometriosis?

Surgery before in-vitro fertilization – Is it beneficial in patients with deep endometriosis? By Eylül GÜN

Deep pelvic endometriosis is thought to be related to infertility by altering the pelvic environment and anatomy due to pelvic adhesions, and the changes in endometrial receptivity contribute to it. The discussion on whether the surgical intervention was beneficial started…

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Quality of life assessment in women with endometrioma

Quality of life assessment in women with endometrioma By Eylül GÜN

Like most chronic diseases, endometriosis poses a significant risk of diminishing the quality of life in patients suffering from it, particularly with its most considerable symptom; chronic pelvic pain. Although it is known that endometriosis is more common in East…

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Evaluation of daily diary for endometriosis-related pain.

Evaluation of daily diary for endometriosis-related pain. By Selma Oransay

Some endometriosis patient-reported outcomes elements have been previously developed in accordance with regulatory and best practice guidelines including Endometriosis Pain Daily Diary, the Endometriosis Symptom Diary, and Endometriosis Impact Scale. The aim of this study was to develop another content-valid…

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Endometriosis: Beyond the naked eye visibility

Endometriosis: Beyond the naked eye visibility By Bahar Yuksel

The gold standard method for endometriosis diagnosis is histopathologic evaluation of the resected lesions. The study conducted by Sara-Michelle Gratton et al. in Canada evaluated the possible effect of developed laparoscopic skills and equipment on the endometriosis diagnosis, and whether…

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Full understanding the role of nervous system in endometriosis could yield new gateways to novel therapeutic approaches

Full understanding the role of nervous system in endometriosis could yield new gateways to novel therapeutic approaches By Nasuhi Engin Aydin

Dr. Velho and associates from Berlin, Germany have recently published their comprehensive review on the role of the nervous system in endometriosis in a recent issue of “International Journal of Molecular Sciences”. Understanding the role of the peripheral nervous system…

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Endometriosis Seems to Affect The Development of the Embryo

Endometriosis Seems to Affect The Development of the Embryo By Özge Özkaya

Embryos development is impaired in embryos from women with endometriosis found a new study published in the Journal of Assisted Reproduction and Genetics. In spite of this, the outcomes of in vitro fertilization (IVF) are similar for patients with endometriosis…

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Is intrauterine insemination effective in women having endometriosis-associated infertility?

Is intrauterine insemination effective in women having endometriosis-associated infertility?  By Hale Goksever Celik

The most common presenting complaints of women with endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Affected women demand therapy for these symptoms of endometriosis, notably fertility problems. Several underlying mechanisms have been proposed to explain endometriosis-associated infertility including anatomic…

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The necessity of laparoscopy for unexplained infertility.

The necessity of laparoscopy for unexplained infertility. By Selma Oransay

The standard for accepting a couple as "infertile" is the inability to conceive after 12 months of regular unprotected intercourse. When this condition is met, assessing the number of motile sperm in the male partner and certifying the patency at…

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The Role of Endometrial Cytokines on the Infertility in Endometriosis Patients

The Role of Endometrial Cytokines on the Infertility in Endometriosis Patients By Eylül GÜN

The intrauterine microenvironment and underlying immunological mechanisms in endometriosis pathogenesis have been a popular research topic, mainly due to the efforts to comprehend the reason to elucidate infertility that these patients suffer from. Because of their superiority to other immune…

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Association of psoriasis and endometriosis

Association of psoriasis and endometriosis By Selma Oransay

Psoriasis is an immune-mediated inflammatory skin disease characterized by scalpy, red, and well-demarcated skin plaques that are observed in 2-4% of the population. Approximately 30% of psoriatic patients additionally have joint pain, stiffness, and swelling called psoriatic arthritis. The mechanism…

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How likely is it to get pregnant and have a baby after undergoing surgery for high stage endometriosis?

How likely is it to get pregnant and have a baby after undergoing surgery for high stage endometriosis? By Eylül GÜN

As one of the most common causes of infertility in women, endometriosis might be surgically interfered with depending on the stage. For Stage I and II endometriosis, surgery is recommended in the latest guidelines to ameliorate fertility rates, however, there…

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Physical activity and exercise in reducing endometriosis symptoms

Physical activity and exercise in reducing endometriosis symptoms By Eylül GÜN

The treatment modalities to date on endometriosis have focused on the symptomatic relief and management of chronic pain. Hormonal suppression sometimes shows intolerable side effects and is known to lose effect after some time. Surgical interventions may not provide a…

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Is it iron that calls vessels to form endometriosis

Is it iron that calls vessels to form endometriosis By Bahar Yuksel

The trigger mechanism of endometriosis formation is still under investigation. But it is clear that there is an iron overload on endometriotic lesions. In the study conducted by Guojing Li et al, the mechanism of iron on endometriosis formation has been…

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Pain alone is not a specific predictor for endometriosis diagnosis

Pain alone is not a specific predictor for endometriosis diagnosis By Hale Goksever Celik

The most common symptoms and signs of women with endometriosis include dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. However, diagnostic delay still occurs due to the broad clinical spectrum of the disease and the absence of non-invasive diagnostic biomarkers. Gordon et…

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The quality of life and mental health in endometriosis patients

The quality of life and mental health in endometriosis patients By Eylül GÜN

One of the most important aspects of having a chronic illness comes with its relative effect on the patients’ quality of life and mental health status. Being among the most debilitating diseases in women in the reproductive period, endometriosis is…

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How Likely Am I to Conceive After Endometriosis Surgery?

How Likely Am I to Conceive After Endometriosis Surgery? By Özge Özkaya

Women with superficial peritoneal endometriosis and just one type of lesion are more likely to conceive after surgery, according to a new study published in the International Journal of Gynecology and Obstetrics.  This is important because patients will be better…

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From Spain: execution for endometriosis and chronic pelvic pain unresponsive to conventional therapies

From Spain: execution for endometriosis and chronic pelvic pain unresponsive to conventional therapies By Selma Oransay

The current conventional therapy for chronic pelvic pain for endometriosis is defined as either hormonal or non-hormonal medical treatment starting with combined oral contraceptives progestins or dienogest, and then gonadotropin-releasing hormone analogs and/or surgery. Although conventional therapies usually are successful, still…

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The relevance of mitosis in endometriotic tissue biopsies

The relevance of mitosis in endometriotic tissue biopsies By Nasuhi Engin Aydin

Dr. Wetzk and co-workers from the Technical University, Dresden, Germany have published a retrospective study on the diagnostic impact of mitotic activity in the endometriotic lesion biopsies in the recent issue of the journal “Geburtshilfe und Frauenheilkunde”. Guidelines highly recommend a…

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The higher the Endometriosis Fertility Index, the higher the chance of getting pregnant

The higher the Endometriosis Fertility Index, the higher the chance of getting pregnant By Hale Goksever Celik

The women who desire to get pregnant may also suffer from fertility problems depending on several mechanisms such as anatomic distortion, peritoneal adhesions, tubal dysfunction, impaired quality of oocytes, and impaired endometrial receptivity. One of the most important problems in…

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Importance of Language in Communicating Endometriosis Pain

Importance of Language in Communicating Endometriosis Pain By Özge Özkaya

Language is of great importance for women with endometriosis to communicate their pain to their doctor, according to a new study published in Frontiers in Global Women's Health. The study also found that additional tools are needed to help women…

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What do endometriosis and ovarian cancer have in common?

What do endometriosis and ovarian cancer have in common? By Bahar Yuksel

While endometriosis is not a malignant disease, it is for sure known that it shares genetic disorders with cancers. In the bioinformatics study applied by Leyi Ni et al, the researchers analyzed the genetic pathways shared by both ovarian cancers…

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A novel target proposal in endometriosis: Phoenixin

A novel target proposal in endometriosis: Phoenixin By Eylül GÜN

As well as being a hormone-dependent reproductive system disorder, endometriosis is known to be multifactorial, which makes its etiopathogenetic mechanisms even harder to understand. Many new targets have been vastly evaluated with the hope of finding a new diagnostic test…

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A study design to improve the patient-centeredness in endometriosis care.

A study design to improve the patient-centeredness in endometriosis care. By Selma Oransay

It is well known that endometriosis causes impaired daily activity and productivity along with energy loss, fatigue, pelvic pain, deep dyspareunia, and further, infertility accompanies all these negative influences. The chronic nature of the disease forces clinicians to plan long-term care…

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Emotions on the 'Surgery Requirement' in patients with bowel endometriosis

Emotions on the 'Surgery Requirement' in patients with bowel endometriosis By Eylül GÜN

Endometriosis is known to have many adverse effects in patients’ lives such as a significant decrease in the quality of life, psychosocial problems, loss of productivity and focus while working. With the constant chronic pain, the patients mostly present with…

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An Overview on Treatment of endometriosis

An Overview on Treatment of endometriosis By Selma Oransay

There are different guidelines by different gynecological societies for the diagnosis and treatment of endometriosis, which is an extremely complex illness.  Kalaitzopoulos and Samartzis et al. from Switzerland worked on and compared six national and two international widely used guidelines to…

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A trial of exogenous melatonin on dysmenorrhea in women "without endometriosis"

A trial of exogenous melatonin on dysmenorrhea in women By Nasuhi Engin Aydin

In their recent article published in “European Journal of Clinical Pharmacology”,  Dr. Söderman and associates from Stockholm report the results of their randomized, double-blind, placebo-controlled trial on the effects of oral melatonin in women with dysmenorrhea -unrelated to endometriosis-. Melatonin is a hormone…

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New Endometriosis Clinical Trial Now Recruiting Participants

New Endometriosis Clinical Trial Now Recruiting Participants By Özge Özkaya

A new clinical trial investigating the effect of cognitive-behavioral therapy on quality of life in patients undergoing surgery for endometriosis is now recruiting participants. The randomized, controlled trial aims to recruit 100 participants, ages 18 to 50 with proven endometriosis…

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Which one is more effective for the preservartion of postoperative ovarian reserve?

Which one is more effective for the preservartion of postoperative ovarian reserve? By Selma Oransay

Although cystectomy is the most preferred treatment of endometrioma, it is still a matter of debate as it may cause a reduction in the quality and number of remaining follicles, especially important for women who are planning to conceive. Anti-Müllerian…

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Placenta praevia and cesarean section more common in patients with ART for Endometriosis

Placenta praevia and cesarean section more common in patients with ART for Endometriosis By Hale Goksever Celik

Even though endometriosis is known to be associated with infertility, these women still have a chance to get pregnant spontaneously or by assisted reproduction techniques (ART) with the aid of recent technological developments. A It has also been shown that…

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Matrix metalloproteinases and their role in endometriosis

Matrix metalloproteinases and their role in endometriosis By Eylül GÜN

The extracellular matrix harbors important macromolecules such as collagen and glycoproteins which are required for tissue remodeling, differentiation, and homeostasis. The main group of enzymes responsible for these properties is called matrix metalloproteinases (MMPs). It has been proven that MMPs…

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Indocyanin Green dye for recognition of occult endometriotic lesions

Indocyanin Green dye for recognition of occult endometriotic lesions By Bahar Yuksel

The surgery for endometriosis is challenging and the resection of all lesions is not accurately related to not catching all lesions under white light (WL) conventional laparoscopy. In the study conducted by Luigi Carlo Turco et al., in a tertiary…

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Evaluation of patient self-reported outcome measures for endometriosis.

Evaluation of patient self-reported outcome measures for endometriosis. By Selma Oransay

Endometriosis symptomology is multifactorial and it changes over time based on the patient's life experience, perceptions, and medical treatment. These changes require the agility of adaptation for both clinicians and patients to respond properly. The documentation of the patient's specific…

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Efficacy of cannabis on endometriosis symptoms

Efficacy of cannabis on endometriosis symptoms By Eylül GÜN

Endometriosis is related to a wide range of symptoms that affect the quality of life of patients in many aspects. Studies have shown malfunctions in the endocannabinoid system in endometriosis patients which led to the idea to target this pathway…

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Endometriosis and women’s social lives, work and education.

Endometriosis  and women’s social lives, work and education. By Hale Goksever Celik

The women with endometriosis present with a broad clinical spectrum including pelvic pain, dysmenorrhea, dyspareunia, and infertility. All of these symptoms and signs may have a negative impact on women’s lives by having endometriosis. Mastrangelo and Turnbull, from Australia, published…

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Herbicide Alters Immune System on the Route to Endometriosis

Herbicide Alters Immune System on the Route to Endometriosis By Bahar Yuksel

A popular environmental pollutant and herbicide named 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) and its receptor named aryl hydrocarbon receptor (AHR) have been suggested for causing endometriosis, but the mechanism was not clear. In the study conducted by  Mahsa Tanha et…

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Intravascular adenomyomatosis: an important entity to be alert

Intravascular adenomyomatosis: an important entity to be alert By Nasuhi Engin Aydin

Pathologists from Stanford University, USA have recently published four novel cases of intravascular adenomyomatosis co-existing with pelvic endometriosis in a recent issue of “Human Pathology”. Intravascular leiomyomatosis is characterized by the presence of smooth muscle in venous and lymphatic spaces…

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A novel in-vitro endometriosis model with KRAS and PIK3CA mutations

A novel in-vitro endometriosis model with KRAS and PIK3CA mutations By Eylül GÜN

A plethora of research has been ongoing to illuminate the pathogenesis of endometriosis which is a multifactorial disease. These studies have proven the association between some mutated cancer driver genes and endometriosis, and links between certain cancers such as ovarian…

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Is breastfeeding beneficial to endometriosis pain?

Is breastfeeding beneficial to endometriosis pain? By Nasuhi Engin Aydin

Dr. Porta team from Italian academic centers have recently published their research in “International Journal of Environmental Research and Public Health” on breastfeeding mothers who were under follow-up for histologically proven endometriosis. The hormonal milieu is believed to have an important…

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International definition and standardization for endometriosis

International definition and standardization for endometriosis By Selma Oransay

There is huge heterogeneity in classifications, subtypes, diagnostic and therapeutic interventions of endometriosis in published literature. The lack of a uniform and widely accepted terminology of the disease rose the necessity to argue and reach a common consensus with organizations,…

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Preoperative Neutrophil-to-Lymphocyte Ratio for prediction of postoperative pregnancy

Preoperative Neutrophil-to-Lymphocyte Ratio for prediction of postoperative pregnancy By Hale Goksever Celik

Among women with endometriosis, 30 to 50 percent are estimated to have infertility, and 25-50% of infertile patients are found to have endometriosis. Anatomic distortion, diminished tubal peristalsis, diminished sperm movements, dysfunctional folliculogenesis, luteal phase dysfunctions, and alterations in endometrial…

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Relationship Goals and Sexual Satisfaction for Couples Coping with Endometriosis

Relationship Goals and Sexual Satisfaction for Couples Coping with Endometriosis By Selma Oransay

"Relationship satisfaction" is based on an individual's emotional judgment. Physical and emotional obstacles may present and negatively affect relationship satisfaction. Endometriosis is associated with multiple life domains, and also includes relationship and sexual satisfaction. Sexual satisfaction, on the other hand,…

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Cross-cultural translation and adaptation of an endometriosis survey

Cross-cultural translation and adaptation of an endometriosis survey By Eylül GÜN

Endometriosis is a disease that presents heterogeneously which makes it hard to identify a causal relationship. A patient-based questionnaire called Endometriosis Participant Questionnaire (EPQ) has been originated by The World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project. It…

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A plea from pathologists: standardized protocols for adenomyosis and endometriosis  

A plea from pathologists: standardized protocols for adenomyosis and endometriosis   By Nasuhi Engin Aydin

Pathologist Drs. Camboni and Marbaix from Brussels, Belgium published their comprehensive review on adenomyosis and endometriosis titled “Ectopic endometrium: the pathologists’ perspective” in a recent issue of the International Journal of Molecular Sciences. Endometriosis and adenomyosis are well-known entities as…

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The effect of hormone therapy after surgical menopause on endometriosis recurrence

The effect of hormone therapy after surgical menopause on endometriosis recurrence By Selma Oransay

Definitive surgery for severe and advanced endometriosis is hysterectomy with bilateral oophorectomy, which may cause vasomotor symptoms, sleep deprivation, mood change, and dyspareunia in the patients. Furthermore, after the surgical removal of the ovaries, the sudden drop in estrogens causes…

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Does Surgery Improve the Digestive Symptoms of Endometriosis?

Does Surgery Improve the Digestive Symptoms of Endometriosis? By Özge Özkaya

Women with deep infiltrating endometriosis involving the bowels have the most significant improvement in gastrointestinal symptoms following surgery. This is according to the findings of a comparative retrospective study in almost 1,500 women.  “Women with severe bowel symptoms and deep…

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Pharmacological Therapy for Endometriosis Pain

Pharmacological Therapy for Endometriosis Pain By Eylül GÜN

The negative effects of endometriosis on women’s quality of life are indisputable. Women who suffer from endometriosis might have to deal with problems in many aspects such as psychological, sexual, social, and economic. Pain which is one of the most…

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Environmental factors play a role in the development of endometriosis

Environmental factors play a role in the development of endometriosis By Hale Goksever Celik

The proposed mechanisms underlying the development of endometriosis may be classified into three groups: in-situ theory, implantation theories, and induction theories. Genetic, hormonal, environmental, and lifestyle-related factors are also involved as no mechanism is solely responsible for endometriosis development. Although there are…

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The new Endometriosis Surgical Complexity Classification: AAGL 2021

The new Endometriosis Surgical Complexity Classification: AAGL 2021 By Selma Oransay

Multiple endometriosis categorizations have been approved in the recent forty years. The American Fertility Society proposed ASRM with a desire to score the impact of the endometriosis in 1996,  which was updated several times later (rASRM), to predict infertility after laparoscopic operations. For…

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Dietary adjustments do not increase the quality of life of women with endometriosis.

Dietary adjustments do not increase the quality of life of women with endometriosis. By Özge Özkaya

Even though dietary changes do not seem to increase patients’ quality of life, they lead to a perceived reduction in symptoms. No specific adjustment in the diet increases the quality of life of women with endometriosis, according to a new…

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Inflammatory and genetical background of endometriosis may yield new therapeutic approaches

Inflammatory and genetical background of endometriosis may yield new therapeutic approaches By Nasuhi Engin Aydin

Elisa Giacomini and colleagues from medical centers in Milan, Italy have published their review manuscript on the inflammatory and genetical pathogenetic background of endometriosis in a recent issue of  “International Journal of Molecular Sciences”, suggesting also new therapeutic approaches. The inflammatory…

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It is "pain" that causes sleep disturbances and fatigue in endometriosis patients

It is By Bahar Yuksel

Endometriosis has been studied previously about its effects on quality of life and the possible effects on sleeping periods. The study conducted by Federica Facchin et al. questioned the reason for endometriosis to cause sleep disturbance. The authors have divided…

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How does adenomyosis affect IVF outcomes?

How does adenomyosis affect IVF outcomes? By Hale Goksever Celik

Adenomyosis is defined as the localization of endometrial tissue in the muscle layer of uterus. Several theories have been proposed to explain the reasons of adenomyosis-associated infertility including uterine dysperistalsis, abnormal transportation of sperm in the uterine cavity, and embryo…

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Green tea as a therapeutic agent in endometriosis

Green tea as a therapeutic agent in endometriosis By Eylül GÜN

Tea is among the most consumed beverages all around the world. It has many kinds which originate from the same plant “Camellia sinensis” but differ in color after the fermentation process. Green tea is the one produced right after the…

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Molecular alterations in endometriosis pathogenesis

Molecular alterations in endometriosis pathogenesis By Eylül GÜN

Endometriosis has been in our lives for decades, however little is known about its pathogenesis making it hard to diagnose and manage. A review study conducted by Balasubramanian et al. from India reveals all the characteristics and the underlying conditions…

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Phytoestrogens could have promising effects in endometriosis management

Phytoestrogens could have promising effects in endometriosis management By Nasuhi Engin Aydin

Dr. Bartiromo and associates from Milan, Italy published a systematic review on phytoestrogens and endometriosis in the periodical “Nutrients”. Endometriosis has features of chronic inflammation based on uncontrolled hormonal response and immune-mediated dysfunctions. Estrogens are endocrine and paracrine agents that could yield…

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Complex Relation Between Body mass index and endometriosis

Complex Relation Between Body mass index and endometriosis By Selma Oransay

This research aimed to find the relationship between BMI and endometriosis especially related to surgical phenotype and lesion location. An observational cohort study was led by  Holdsworth-Carson et al, from Australia. The article was recently published in "RBMO" . Many earlier studies report…

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Urinary Function Alterations after Surgery for Deep Endometriosis.

Urinary Function Alterations after Surgery for Deep Endometriosis. By Selma Oransay

Laparoscopic surgery is a mainstay therapy for symptomatic patients with DE. Although our findings of improvement in many domains of urinary function are encouraging, postoperative deterioration in urinary function was found for patients with initial normal function. More research is…

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Resveratrol for endometriosis

Resveratrol for endometriosis By Bahar Yuksel

Endometriosis has been studied previously about its inflammatory nature and its tendency for causing macrophage disfunction. In the study conducted by Chunyan Wang et al, the researchers analyzed the effect of a flavonoid, "resveratrol" on endometriosis lesions and the mechanism…

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The comparison of the effect of hemostatic techniques on ovarian reserve during endometrioma cystectomy

The comparison of the effect of hemostatic techniques on ovarian reserve during endometrioma cystectomy By Hale Goksever Celik

The possible negative effect of the surgical excision of endometriomas on the ovarian reserve has brought up the meticulous implementation of the decision for surgical approach. Dr. Raquel Silveria da Cunha Araujo et al, from Brazil, published a study titled as…

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Endometriosis, pelvic inflammatory disease and ovarian cancer

Endometriosis, pelvic inflammatory disease and ovarian cancer By Eylül GÜN

Endometriosis is a locally aggressive and chronic inflammatory disease and it is now known that with various genetic pathways it creates susceptibility to certain cancers, the most common being ovarian cancer. Pelvic inflammatory disease on the other hand creates a…

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Persistence of Chronic Pelvic Pain after Hysterectomy

Persistence of Chronic Pelvic Pain after Hysterectomy By Hale Goksever Celik

Chronic pelvic pain is defined as the "pain in the pelvic area that lasts for 6 months or longer". There are several gynecological, urological, and gastrointestinal reasons for the development of chronic pelvic pain. Nociceptive pain or central sensitization is…

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Assisted Reproductive Technology Outcomes in Women with and without Endometriosis

Assisted Reproductive Technology Outcomes in Women with and without Endometriosis By Selma Oransay

Endometriosis causes infertility in one-third of patients, while in approximately 25-35% of infertile women, the cause is endometriosis.  The primary interest and the question of Moss et al. from the University of Queensland, Brisbane, Australia was "the differences in the…

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Etiopathogenesis of Endometriosis and Links with Endometrial Cancer

Etiopathogenesis of Endometriosis and Links with Endometrial Cancer By Nasuhi Engin Aydin

Professor Terzic and colleagues from the Medical School of Nazarbayev University, Kazakhstan published their review on the molecular aspects of endometriosis and endometrial cancer in “International Journal of Molecular Sciences”. The etiopathogenesis of endometriosis has remained controversial, with recent studies…

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How to Reduce Pain After Laparoscopic Surgery

How to Reduce Pain After Laparoscopic Surgery By Özge Özkaya

Using humidified warm gas with forced-air warming blanket during laparoscopic surgery resulted in significantly less pain in the recovery room, according to a new study published in the journal "Surgical Endoscopy". In patients with endometriosis, using humidified warm air even…

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Routine preoperative ureteral stent and complications in Deep Infiltrating Endometriosis

Routine preoperative ureteral stent and complications in Deep Infiltrating Endometriosis By Bahar Yuksel

Deep infiltrative endometriosis is a devastating disease that includes both anterior and posterior compartments, and ureteral infiltration with endometriotic nodules affects 1 to 6% of all deep infiltrative endometriosis patients. In the study conducted by Giulia Borghese et al., the…

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Lead and cadmium exposures of female workers should be reduced as much as possible

Lead and cadmium exposures of female workers should be reduced as much as possible By Nasuhi Engin Aydin

Min-Gi Kim and associates from Korea published their results on the possible effects of lead and cadmium exposure in endometriosis induction and severity in a recent issue of “International Journal of Environmental Research and Public Health”. Endometriosis is an illness…

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Impact of surgery before IVF in infertile women with endometrioma

Impact of surgery before IVF in infertile women with endometrioma By Hale Goksever Celik

Among the women with endometriosis, 30 to 50% are estimated to have infertility. On the contrary, among women who present with infertility, 25 to 50% are estimated to also have endometriosis. Several mechanisms have been proposed to explain the association…

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Small chain fatty acids produced by gut microbiota: Could that be the missing milestone for endometriosis

Small chain fatty acids produced by gut microbiota: Could that be the missing milestone for endometriosis By Bahar Yuksel

Endometriosis is a worldwide problem but still, the underlying mechanism and optimal treatment options are controversial. In the study conducted by Sangappa B Chadchan et al., the researchers investigated the possible relationship between gut microbiota and endometriosis. A study published…

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Ovarian cancer risk in endometriosis and adenomyosis

Ovarian cancer risk in endometriosis and adenomyosis By Eylül GÜN

Through the historical development of the nomenclature for endometriotic tissue found inside and/or outside the uterus, many terminologies have been used. The accepted terminology is still the one introduced by Sampson: “Endometriosis”. “Adenomyosis” also known as “endometriosis interna” which is…

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Uterine cancer risk in "endometriosis" and "adenomyosis"

Uterine cancer risk in By Selma Oransay

Adenomyosis and endometriosis share similar characteristics, and endometriosis is reported to have an increased risk of ovarian cancer. However, the risk of uterine cancer is not clear yet. Hermens and colleagues from Catharina Hospital, from the Netherlands, designed a population-based…

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Endogenous cannabinoids are related to endometriosis pain

Endogenous cannabinoids are related to endometriosis pain By Eylül GÜN

Pain, specifically dysmenorrhea is the most important symptom of endometriosis. Prostaglandins are the main director of the pain process in dysmenorrhea, therefore the mechanisms affecting the prostaglandin metabolism have been studied in order to find a treatment for pain, and found that…

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Dienogest treatment increases the risk of Endometriosis reoperation rate

Dienogest treatment increases the risk of Endometriosis reoperation rate By Selma Oransay

The common and accepted therapy of endometriosis is surgery, however medical treatment such as nonsteroidal anti-inflammatory drugs, gonadotropin-releasing hormone agonists, oral contraceptives and oral progestins are used for either relieving pain or to prevent recurrences and reoperation. Due to bone loss and…

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Body Mass Index and indicators of metabolic syndrome in women with Endometriosis

Body Mass Index and indicators of metabolic syndrome in women with Endometriosis By Hale Goksever Celik

Endometriosis is a disease of reproductive-aged women and has common pathophysiological mechanisms with other chronic health morbidities due to its estrogen-dependent chronic inflammatory background. The changes in the inflammatory components of adipose tissue may have an impact on the quality of…

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Potential new Target to Reduce Endometriosis Pain

Potential new Target to Reduce Endometriosis Pain By Özge Özkaya

The inflammatory mediators, bradykinin, and bradykinin B1 receptor may play a role in the onset of endometriosis-associated pain according to a new study by Chinese researchers. They do so by inducing the prostaglandin signaling pathway. Therefore, targeting these biological pathways…

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Best practice: How to reduce intraoperative bleeding?

Best practice: How to reduce intraoperative bleeding? By Selma Oransay

Although laparoscopic hysterectomy is a popular and common approach for removing benign uterine lesions, some technical steps especially concerning uterine artery closure depend on the surgeon's preference. Uterine artery ligation may be performed either at the uterus level, which is common…

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A new "survey-based" endometriosis diagnostic tool

A new By Bahar Yuksel

Endometriosis is a disease that is diagnosed years after its appearance which causes life quality impairment to patients. It is crucial for the patient to find out the probability of the presence of endometriosis, for applying to healthcare providers before…

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Altered Decidualization and Pregnancy Complications

Altered Decidualization and Pregnancy Complications By Nasuhi Engin Aydin

Dr. Carlo Ticconi and colleagues from Italy published their comprehensive review manuscript “Clinical consequences of defective decidualization” in the June 2021 issue of “Tissue and Cell”. Currently, there has been growing research interest in the study of decidualization, and knowledge of…

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Catching endometriosis from the front line: educating general practitioners

Catching endometriosis from the front line: educating general practitioners By Bahar Yuksel

It should be repetitively pronounced that "endometriosis is very common and it is very important to diagnose it as soon as possible before it causes lifelong damage to women’s lives". The sooner the better concerning the diagnosis, and this is…

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A rare complication of  endometriosis

A rare complication of  endometriosis By Selma Oransay

Morales et al. from the Monterrey School of Medicine, Mexico, reported a case of bowel intussusception in a woman with severe endometriosis to draw attention to this very rare endometriosis complication. The case is a 27 years old young female…

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Not all endometriotic lesions behave similar to the eutopic endometrium

Not all endometriotic lesions behave similar to the eutopic endometrium By Eylül GÜN

The most widely accepted theory of endometriosis pathophysiology is Sampson’s theory of retrograde menstruation which suggests the ectopic lesions undergo the same hormonal and morphological changes as eutopic endometrium during the menstrual cycle. Recent studies have shown that only a…

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Research Identifies New Genes That Could Be Targeted to Treat Endometriosis

Research Identifies New Genes That Could Be Targeted to Treat Endometriosis By Özge Özkaya

Researchers identified three new genes that could help understand the invasiveness of endometriosis. They also identified one new gene that could be related to the recurrence of the disease. These genes may potentially be new therapeutic targets for endometriosis. In…

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Awareness is the first step toward endometriosis treatment

Awareness is the first step toward endometriosis treatment By Dr. Youngran Park

We want to reiterate the importance of endometriosis, by handling the paper entitled "Endometriosis awareness: screaming at the top of our voices" published on April 2021 in the journal “Women & Health”. The Endometriosis Awareness Month of 2021 was a little different,…

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A new "nonhormonal" treatment target in endometriosis

A new By Eylül GÜN

Endometriosis is a chronic inflammatory condition that affects millions of women globally. With pelvic pain being its most common symptom, the cost of the treatment of disease-associated symptoms has been found to be almost as high as type 2 diabetes.…

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The incidence of endometriosis may vary over time according to age, period and cohort

The incidence of endometriosis may vary over time according to age, period and cohort By Hale Goksever Celik

Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. Early diagnosis has importance as endometriosis impairs the quality of life of patients and creates a serious social and economic burden. Fortunately, earlier diagnosis and management of endometriosis becomes…

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A new assessment tool for the multi-dimensional burden of endometriosis

A new assessment tool for the multi-dimensional burden of endometriosis By Eylül GÜN

Endometriosis is a disease that has multiple effects on patients’ lives in various ways. The quality of life, the status of the patient’s relationships, the continuity and productivity in the patient’s education and work environment, and psychological, emotional, and even…

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Ovarian Cancer Survival in the presence of Endometriosis

Ovarian Cancer Survival in the presence of Endometriosis By Özge Özkaya

Women with ovarian cancer and histologically proven endometriosis have longer overall survival compared to those with ovarian cancer but no endometriosis, found a study published in the American Journal of Obstetrics & Gynecology.  “[…] Women diagnosed as having ovarian cancer…

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The added value of transvaginal hydro-laparoscopy for infertile women

The added value of transvaginal hydro-laparoscopy for infertile women By Selma Oransay

The added value of invasive diagnostic laparoscopy has been questioned, postponed by the increased usage of ultrasonography for the evaluation of infertile patients. Gordts et al. from Life Expert Center, Leuven, Belgium have been working on an alternative way called "transvaginal hydro-laparoscopy" to…

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The role of physical examination and interview in Endometriosis Diagnosis

The role of physical examination and interview in Endometriosis Diagnosis By Bahar Yuksel

Today we know that the most accurate diagnosis of endometriosis necessitates surgery and histopathological examination of the excised lesions. However, many women are misdiagnosed due to various symptoms of endometriosis which mystify gastrointestinal, urinary, and musculoskeletal diseases. Nawrocka-Rutkowska and colleagues…

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The incidence and prevalence of endometriosis in a United States population-based study .

The incidence and prevalence  of endometriosis in a United States population-based study . By Selma Oransay

To define the accurate incidence and prevalence estimates of endometriosis among nonselected cohorts in the USA, Christ et al. from the Departments of Obstetrics and Gynecology of the University of Washington, Seattle, planned a retrospective cohort study using the electronic KPWA…

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Long noncoding RNAs to predict the endometriosis recurrence

Long noncoding RNAs to predict the endometriosis recurrence By Hale Goksever Celik

Despite extensive research, the exact pathophysiologic mechanism of endometriosis remains unclear; and the absence of non-invasive biomarkers to diagnose endometriosis is still a big problem both for clinicians and patients. The recurrence of endometriosis is another challenge that is difficult…

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Endometriosis & adolescents: Overcoming the diagnostic delay via education

Endometriosis & adolescents: Overcoming the diagnostic delay via education By Eylül GÜN

Although the diagnosis of endometriosis is still not timely even in adults, due to its common under- or misdiagnosis in adolescents, the diagnostic delay may further cause the adolescent women to wait to seek medical treatment.  A group of researchers…

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Chemical Found in Self-Care Products May Be Linked to Endometriosis

Chemical Found in Self-Care Products May Be Linked to Endometriosis By Özge Özkaya

There may be a link between exposure to phthalates and endometriosis according to a new study published in the Journal of Assisted Reproduction and Genetics. Although more research is needed, these findings could be translated into clinical practice according to…

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Transvaginal Ultrasound Accuracy for Uterosacral Ligament, Torus Uterinus and Posterior Fornix Endometriosis

Transvaginal Ultrasound Accuracy for Uterosacral Ligament, Torus Uterinus and Posterior Fornix Endometriosis By Selma Oransay

The accuracy of transvaginal ultrasonography for the diagnosis of deep endometriosis depends on the location. The sensitivity is up to 80% when the lesion is in the rectosigmoid, but it decreases up to 66% for the detection of posterior vaginal…

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The clues for pain and infertility in endometriosis/adenomyosis complex

The clues for pain and infertility in endometriosis/adenomyosis complex By Nasuhi Engin Aydin

Drs. Gruber and Mechsner from Charite University-Berlin, Germany published their comprehensive review on pathophysiological background of endometriosis and adenomyosis in the scientific periodical “Cells”. Chronic pain and fertility problems are the main clinical issue in endometriosis and adenomyosis patients. In order to…

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Technical Facts for the Prevention of Complications After Deep Endometriosis Surgery

Technical Facts for the Prevention of Complications After Deep Endometriosis Surgery By Özge Özkaya

There are no differences in the risk of rectovaginal fistula in women with rectovaginal endometriosis who were managed by a liberal or restrictive policy of preventive stoma according to a study by French researchers published in the Journal of Minimally…

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Non-pharmacological self-care: dietary modifications in women with endometriosis.

Non-pharmacological self-care: dietary modifications in women with endometriosis. By Selma Oransay

The academic interest on the role of diet in endometriosis has grown due to its possible relation with inflammation, estrogenic activity, and menstrual cycles. Multiple dietary strategies and prescriptions are being used to deal with the pelvic pain and gastrointestinal…

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How to measure the length of recto-sigmoid deep endometriosis reliably?

How to measure the length of recto-sigmoid deep endometriosis reliably? By Eylül GÜN

An in-depth assessment is needed when rectosigmoid deep endometriosis is decided to be treated surgically. Surgery carries a lot of risks and it is not always easy to decide which procedure the patient would benefit the most from. Patient-oriented surgical…

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A scoping review proposal for the diagnostic and treatment delay of endometriosis

A scoping review proposal for the diagnostic and treatment delay of endometriosis By Hale Goksever Celik

Women with endometriosis suffer from pain for a prolonged time due to diagnostic and treatment delay which is the most challenging aspect of endometriosis. Cromeens et al, from the USA, published a review entitled “Timing, delays, and pathways to the…

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Strong Geographical Gradient in Endometriosis Incidence Identified

Strong Geographical Gradient in Endometriosis Incidence Identified By Özge Özkaya

The geographical distribution of new endometriosis cases showed a very strong north-south spatial gradient in the highly industrialized Friuli Venezia Giulia region of Italy, according to a new study published in the International Journal of Environmental Research and Public Health. “The cluster of…

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Not just the pain stops but also the bowel function improves after DIE surgery

Not just the pain stops but also the bowel function improves after DIE surgery By Bahar Yuksel

Bowel endometriosis and the techniques to operate it have always been a challenge. The study conducted by Beraldo et al., from Brazil, highlighted the results of an effective nerve-sparing bowel surgery on endometriosis lesions and its long-term effects on patients. The…

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Exploring a bonafide biomarker to predict endometriosis

Exploring a bonafide biomarker to predict endometriosis By Eylül GÜN

Endometriosis is a complex disease affecting many women in the reproductive age group. As it is important to figure out the mechanisms responsible for the disease, it is also crucial to identify biomarkers that can be used in the diagnosis…

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Promising therapeutic results in experimental endometriosis model

Promising therapeutic results in experimental endometriosis model By Nasuhi Engin Aydin

Tiziana Genovese and associates from Italian academic centers reported their pioneering findings in an experimental model of endometriosis administering an anti-tumor agent and glucocorticoid combination, published in the scientific periodical “International Journal of Molecular Sciences”. Endometriosis is a worldwide common disease…

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It is not that simple: endometriomas are almost never alone

It is not that simple: endometriomas are almost never alone By Bahar Yuksel

Endometriomas are the widely and easily diagnosed type of endometriosis. They are usually treated by gynecologic surgeons and are thought to be alone most of the time. The study conducted by Piriyev et al highlighted the coexistence of extraovarian endometriosis…

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Is the presence of nerve fibers in the endometrium associated with endometriosis?

Is the presence of nerve fibers in the endometrium associated with endometriosis? By Eylül GÜN

Endometriosis is a common disease in reproductive women and diagnostic imaging have a limited role in its diagnosis. The gold standard diagnostic method remains to be the histopathological examination of the tissue obtained via laparoscopy. One of its most common…

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Resveratrol, isoflavones and puerarin have favorable in vivo results in endometriosis studies

Resveratrol, isoflavones and puerarin have favorable in vivo results in endometriosis studies By Nasuhi Engin Aydin

Xia Cai and associates from research units located in China published their review article on the relationship between phytoestrogens and endometriosis in the scientific periodical named “Pharmacology”. The great variation in the prevalence of endometriosis raises questions in regard to…

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Endometriosis and Rheumatoid Arthritis, Could There Be a Link?

Endometriosis and Rheumatoid Arthritis, Could There Be a Link? By Özge Özkaya

Patients with endometriosis have a higher risk of rheumatoid arthritis according to a study published in the journal Rheumatology. This finding suggests that rheumatologists should be especially mindful of the possibility of underlying endometriosis when treating women with rheumatoid arthritis.…

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Postoperative Opioid use after Robotic operations for endometriosis, compared to non-endometriosis

Postoperative Opioid use after Robotic operations for endometriosis, compared to non-endometriosis By Bahar Yuksel

Endometriosis is a common disease in patients of fertile age, and many patients require surgery. Robotic surgery is accepted as a minimally invasive method in the management of endometriosis and other benign conditions. However, postoperative pain status and the best pain…

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Ureteral endometriosis and its management

Ureteral endometriosis and its management By Eylül GÜN

Urinary tract endometriosis prevalence is hard to determine since almost half of the women with this condition appear asymptomatic. The most common form is bladder endometriosis followed by ureteral endometriosis which is seen more rarely. Ureteral endometriosis is usually located…

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Does hyaluronic acid have a role in endometriosis?

Does hyaluronic acid have a role in endometriosis? By Nasuhi Engin Aydin

Pei-Hsiu Yu and associates from Tainan, Taiwan, published their results of original research on the role of hyaluronic acid in endometriosis formation in a recent issue of  "Taiwanese Journal of Obstetrics and Gynecology". Hyaluronic acid, a glycosaminoglycan protein in the…

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Medical Examination Reduces Anxiety in Women With Suspected Endometriosis

Medical Examination Reduces Anxiety in Women With Suspected Endometriosis By Özge Özkaya

Anxiety levels go down after medical examination in women with suspected endometriosis, found a study by Italian researchers that was published in the Journal of Psychosomatic Research. This was especially pronounced in women who had higher baseline distress and who…

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Analyses of the main classification systems of endometriosis in terms of utrasound, MRI and surgery

Analyses of the main classification systems of endometriosis in terms of utrasound, MRI and surgery By Selma Oransay

Several classifications made by gynecologists, image readers, and radiologists lead to confusion while describing the situation and estimating the progress of endometriosis. Daniela Fischerova team from the Charles University of Prague, Czech Republic, analyzed the main classifications of endometriosis in three…

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Does exercise have an effect on pain perception in women with endometriosis?

Does exercise have an effect on pain perception in women with endometriosis? By Hale Goksever Celik

Endometriosis is an inflammatory disease causing pain symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain, and also infertility. Several medical and surgical treatment options have been developed to improve quality of life of these women. Despite extensive research, the optimal…

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MicroRNAs in the pathogenesis of endometriosis and infertility

MicroRNAs in the pathogenesis of endometriosis and infertility By Eylül GÜN

The gold standard in the diagnosis of endometriosis is laparoscopy and histopathological diagnosis, however search for a non-invasive method has been ongoing. Some biomarkers such as Cancer Antigen 125 have been thought to be useful, but because of their low…

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A hot research topic: macrophage reprogramming for endometriosis treatment

A hot research topic: macrophage reprogramming for endometriosis treatment By Nasuhi Engin Aydin

 Daria Artemova and colleagues from several research institutes of the Russian Federation have published their review on the cellular aspects of endometriosis related to macrophages, particularly emphasizing  promising therapeutic options for the future in "International Journal of Molecular Sciences". Macrophages have…

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The Severity of Pain Does not Predict Endometriosis or its Stage, Study Confirms

The Severity of Pain Does not Predict Endometriosis or its Stage, Study Confirms By Özge Özkaya

The intensity of pain a woman experiences could predict whether or not she would undergo laparoscopic surgery. However, it could not predict whether she has endometriosis or in case she did, the severity of her disease. This is according to…

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The relationship between microbiota and endometriosis

The relationship between microbiota and endometriosis By Eylül GÜN

Endometriosis is a multifactorial and complex disease that results in an inflammatory state. This persistent inflammatory state is known to cause immune dysregulation. In the immunopathogenesis of endometriosis, activated macrophages, increased neutrophils, impaired natural killer cells, altered T-cell differentiation, and…

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Predictors for achieving pregnancy in patients with adenomyosis and endometriosis

Predictors for achieving pregnancy in patients with adenomyosis and endometriosis By Bahar Yuksel

Adenomyosis and endometriosis are benign conditions, however, both situations are associated with deterioration of life quality, a requirement of hospital administrations, and infertility. Laparoscopic surgery is the main treatment option especially for women who desire pregnancy. Shi and colleagues aimed…

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A pictorial overview of abdominal wall endometriosis

A pictorial overview of abdominal wall endometriosis  By Hale Goksever Celik

Abdominal wall endometriosis is the most frequent location of extrapelvic endometriosis, and defined as the presence of ectopic endometrial tissue between the peritoneum and the skin through the abdominal wall. Although obstetric or gynecologic surgical history is indispensable for the…

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New molecular insights in endometriosis pathogenesis

New molecular insights in endometriosis pathogenesis By Nasuhi Engin Aydin

Dr. Rosalba Siracusa and associates from Messina University, Italy, have published their research on cellular pathogenesis of experimental endometriotic lesions in the recent issue of the "International Journal of  Molecular Sciences". Endometriosis is a debilitating chronic estrogen-dependent inflammatory condition and…

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Outcomes of chronic pelvic pain of endometriosis after laparoscopic surgery

Outcomes of chronic pelvic pain of endometriosis after laparoscopic surgery By Selma Oransay

The prevalence of endometriosis is up to 35-50% among patients with pelvic pain. Among several medical and surgical options to relieve chronic pelvic pain, surgical options are the preferred method but this depends on patients' age, fertility desire, and disease…

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How Does Endometriosis Affect Patients Quality of Life?

How Does Endometriosis Affect Patients Quality of Life? By Özge Özkaya

Health-related quality of life is significantly lower in patients with endometriomas or deep infiltrating endometriosis compared to women without the disease. This is according to the results of a recent study in adult Spanish women that was published in the "International…

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Postoperative ovulation induction in infertile women with minimal to mild endometriosis

Postoperative ovulation induction in infertile women with minimal to mild endometriosis By Hale Goksever Celik

Infertility is an important problem that is encountered in 30-50% of women with endometriosis. Several etiopathogenetic mechanisms for the development of reproductive problems in women with endometriosis have been proposed including abnormal peritoneal microenvironment, ovarian dysfunction and/or decreased oocyte quality,…

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Combined contraceptive pills and immune system cells in the endometriotic cyst wall

Combined contraceptive pills and immune system cells in the endometriotic cyst wall By Nasuhi Engin Aydin

Dr. Wanwisa Waiyaput and associates from Mahidol University, Bangkok, Thailand, have published their results on the immune regulatory cells of the surgically resected endometriotic cyst walls in the “Journal of Ovarian Research”. The defective immune response is believed to have…

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Is the information on Facebook groups about endometriosis accurate?

Is the information on Facebook groups about endometriosis accurate? By Eylül GÜN

The use of social media platforms has been increasing day by day. The coronavirus pandemic has attributed to this immensely. Facebook pages and groups are among the most commonly used platforms to share knowledge, seek emotional support, and learn. While…

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Adhesion Barrier Helps After Endometriosis Surgery

Adhesion Barrier Helps After Endometriosis Surgery By Özge Özkaya

An adhesion barrier, named "4DryField® PH" significantly reduced the formation of adhesions following endometriosis surgery, according to a new study by German scientists.  The formation of adhesions following endometriosis surgery is a severe problem that affects 90% of patients. The…

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Women reject using hormonal drugs for endometriosis, an accelerating need for nonhormonal medications

Women reject using hormonal drugs for endometriosis, an accelerating need for nonhormonal medications By Bahar Yuksel

Although the pathophysiology of endometriosis is poorly understood, endocrine drugs are widely used for reducing inflammation and patients’ symptoms. Burla and colleagues aimed to evaluate the patients’ thoughts and expectations about the endocrine drugs which are used in the treatment…

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Managing Persistent Pelvic Pain in a distinct "pain" clinic

Managing Persistent Pelvic Pain in a distinct By Selma Oransay

Persistent pelvic pain is an important problem producing physiological stress and productivity loss during the reproductive period of women. A specific pelvic pain clinic named "Mater Health Persistent Pelvic Pain Clinic" was established in 2017 in a part of the emergency…

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Retinol-binding protein in endometriosis pathogenesis

Retinol-binding protein in endometriosis  pathogenesis By Nasuhi Engin Aydin

Dr. Jae Chul Lee and associates from the Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, have published the recent results of their research on endometriosis regarding the role of retinol-binding protein4…

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What causes distress in women with endometriosis?

What causes distress in women with endometriosis? By Eylül GÜN

Endometriosis is a disease that affects a woman’s life from many different aspects; emotionally, sexually, and physiologically. With the burden of the distress caused by the disease, most women suffer from anxiety and depression. This results in lower self-esteem and…

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The Surgical Management of Endometriosis of the Ureter and Bladder

The Surgical Management of Endometriosis of the Ureter and Bladder By Özge Özkaya

Laparoscopic surgery is feasible and safe to manage endometriosis of the ureter and bladder, according to a new study published in the Journal of Minimally Invasive Gynecology. According to the authors of the study, ureteral resection is more strongly associated…

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Factors affecting complications and the recurrence of operated deep infiltrating endometriosis

Factors affecting complications and the recurrence of operated deep infiltrating endometriosis By Selma Oransay

Deep infiltrating endometriosis is classified as penetrating the endometrial tissues more than 5 mm deep on the peritoneal surface, mainly uterosacral ligament, rectovaginal septum, ovarian fossa, pelvic peritoneum, bowels, ureters, and bladder. Treatment of the disease depends on the need…

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The higher the cyst fluid iron concentration, the more severe the pain symptom for endometrioma

The higher the cyst fluid iron concentration, the more severe the pain symptom for endometrioma By Hale Goksever Celik

Endometriosis usually is encountered in three different forms: superficial peritoneal endometriosis, ovarian cysts (endometrioma) and deep infiltrating endometriosis. Endometrioma can be identified as cystic lesions consisting of dark brown endometrial fluid and are sometimes referred to as "chocolate cysts." The presence…

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Patient- centeredness in endometriosis

Patient- centeredness in endometriosis By Bahar Yuksel

Endometriosis is common in fertile age, and women with endometriosis are suffering from serious symptoms including pelvic discomfort, dysmenorrhea, and infertility. Due to resemblances of endometriosis symptoms with other diseases, most endometriosis patients are faced with delays in diagnosis. To…

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Migraine, endometriosis and plasma "Calcitonin Gene-Related Peptide"

Migraine, endometriosis and plasma By Eylül GÜN

Calcitonin gene-related peptide (CGRP) is a neurotransmitter that takes part in migraine and is now thought to have a role in endometriosis. The role of CGRP is well known in migraine, it is released from neurons during acute attacks and…

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Vulvo- Perineal Endometriosis: From diagnosis to treatment

Vulvo- Perineal Endometriosis: From diagnosis to treatment By Bahar Yuksel

Vulvo- Perineal endometriosis is a very rare condition that should be kept in mind to be diagnosed and treated. Due to its very rare occurrence, most of the information in the literature on vulvo-perineal endometriosis is based on case reports…

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The need for the standardization of diagnostic protocols for "adenomyosis"

The need for the standardization of diagnostic protocols for By Nasuhi Engin Aydin

Dr. Squillace and associates from Brasilian Academic and Health Centers published their paper titled “Adenomyosis and in vitro fertilization impacts- a literature review” in a recent issue of "JBRA Assisted Reproduction". As common gynecological ailment adenomyosis frequently coexists with endometriosis.…

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The effect of COVID-19 pandemic on patients with endometriosis

The effect of COVID-19 pandemic on patients with endometriosis By Bahar Yuksel

COVID-19 pandemic and related conditions, including transport restrictions, social isolation, and difficulties accessing the professional health system, affected many women’s healthcare and daily routine. Evans and colleagues investigated the impact of COVID-19 and COVID-19 related parameters on endometriosis patients’ health…

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The genomic linkage between ovarian cancer and endometriosis

The genomic linkage between ovarian cancer and endometriosis By Eylül GÜN

Endometriosis has been proven to be the precursor of ovarian clear cell and endometrioid carcinomas, however, it is not well understood why and how endometriosis goes into malignant transformation.  To address this issue, in their review article, Dr. Yachida and…

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How to predict the complications after laparoscopic bowel resection in women with endometriosis

How to predict the complications after laparoscopic bowel resection in women with endometriosis By Hale Goksever Celik

The endometriotic lesions infiltrating the bowel wall more than 5 mm. are called "deep infiltrating endometriosis". The patients having bowel involvement may have constipation, diarrhea, tenesmus, or rectal bleeding. Surgical management is the main treatment modality to provide benefits on pain, infertility,…

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Endometriosis from the "EVOLUTIONARY" point of view

Endometriosis from the By Nasuhi Engin Aydin

Natalie Dinsdale and associates from the Canadian Simon Fraser University Department of Biological Sciences published a critical review titled “ The evolutionary biology of endometriosis” in a recent issue of the journal “Evolution, medicine and public health”. This review focuses…

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The Communication Gap Between Specialists for Endometriosis Diagnosis and Management

The Communication Gap Between Specialists for Endometriosis Diagnosis and Management By Eylül GÜN

An approach to help the different specialties which work as a team but lack sufficient communication in endometriosis management build better communication was proposed by Leonardi et al. from Australia and Canada in their opinion article which was published in…

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Endometriosis alters women’s self-behavior

Endometriosis alters women’s self-behavior By Bahar Yuksel

Endometriosis diagnosis is given to almost 15% of women of reproductive age. Although endometriosis could be asymptomatic, many women with endometriosis are faced with several symptoms including chronic pelvic pain, dysmenorrhea, dyspareunia, dyschezia, dysuria, and infertility. The wide variability of…

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Evaluation of preoperative risk factors of ureteral endometriosis

Evaluation of preoperative risk factors of ureteral endometriosis By Selma Oransay

Endometriosis affects the urinary tract in 1% to 5.5% of the patients, and among them, bladder involvement is 70-85%, while ureteral involvement alone is 9% to 23%.  Ureteral endometriosis is most commonly unilateral, especially on the left side, usually affecting…

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Promising potential research topic: diagnostic biomarkers for endometriosis

Promising potential research topic: diagnostic biomarkers for endometriosis By Nasuhi Engin Aydin

Dr. Toczek and collegues from the Department of Gynecology, Obstetrics and Oncological Gynecology of Medical University of Silesia in Katowice, Poland, have  published a review paper on possible diagnostic aid of cytokines in endometriosis. This review appears in May issue…

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Endometriosis Surgery Improves Sex Life

Endometriosis Surgery Improves Sex Life By Özge Özkaya

Women who underwent laparoscopic resection surgery to treat their deep infiltrating endometriosis had improved sexual quality of life and health-related quality of life according to a new study published in the Journal of Minimally Invasive Gynecology. These findings are important…

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Myeloid-Derived Suppressor Cells are gaining importance in endometriosis

Myeloid-Derived Suppressor Cells are gaining importance in endometriosis By Nasuhi Engin Aydin

Dr. Wertel and associates from Polish academic centers published their sentimental review paper on the role of "Myeloid-Derived Suppressor Cells" in human diseases, in a recent issue of  Cells. Endometriosis, the most common gynecological disease affecting about 10% of women globally,…

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Postoperative infertility management using Endometriosis Fertility Index in endometriotic women

Postoperative infertility management using Endometriosis Fertility Index in endometriotic women By Selma Oransay

"Endometriosis Fertility Index '' score, described by the World Endometriosis Society in 2017, is a robust score and assists to predict the spontaneous pregnancy rate of women with endometriosis, within 3 years after their operation. Its calculation is possible by patient…

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Could There Be a Relationship Between Endometriosis and the "Restless Leg Syndrome"?

Could There Be a Relationship Between Endometriosis and the By Özge Özkaya

Women with endometriosis have a significantly higher prevalence of restless leg syndrome according to a study published in the scientific journal "Frontiers in Endocrinology". This is the first study highlighting such an association between the two conditions. These findings are important…

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Progestin suppression for endometriosis before IVF

Progestin suppression for endometriosis before IVF By Hale Goksever Celik

“Dienogest is a suitable and safe substitute for GnRHa pretreatment in endometriosis patients”, according to the Khalifa et al., from Egypt. Endometriosis is one of the leading reasons for infertility due to decreased oocyte/embryo quality, fertilizability, tubal function, and aberrant endometrial…

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The endless burden: sexual dysfunction and endometriosis

The endless burden: sexual dysfunction and endometriosis By Bahar Yuksel

The relationship between endometriosis and sexual health in women is one of the hottest topics in obstetrics and gynecology practice. There are some previous reports that investigated the effect of endometriosis on the loss of libido, arousal disorder, orgasmic dysfunction,…

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What Happens to Endometriosis Patients After Endometriosis Surgery?

What Happens to Endometriosis Patients After Endometriosis Surgery? By Özge Özkaya

Although few patients with endometriosis who undergo a hysterectomy need repeat surgery, up to 25% of them need minor surgery. Around 20% of patients who undergo conservative surgery with ovarian preservation require additional endometriosis surgery. Up to one in three…

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Endometriosis in intestine! Segmental resection or linear nodulectomy?

Endometriosis in intestine! Segmental resection or linear nodulectomy? By Bahar Yuksel

Intestinal involvement of endometriosis is common, and the incidence was defined between 45-56%. Previous studies investigating the role of surgery in the management of intestinal endometriosis reported improvement of life quality in up to 95% of cases following surgery. However,…

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Optimal management of infertility in endometriosis patients

Optimal management of infertility in endometriosis patients By Hale Goksever Celik

Pelvic pain and infertility are the main symptoms of endometriosis patients. Although the pathophysiological mechanism for infertility is not clearly understood, there are several theories explaining decreased fertility potential in women with endometriosis. Ata and Telek, from Koc and Istanbul Universities…

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The association of chronic endometritis, endometriosis and tubal infertility

The association of chronic endometritis, endometriosis and tubal infertility By Selma Oransay

Holzer et al. from the Department of Gynecologic Endocrinology and Reproductive Medicine of  Medical University of Vienna, Austria, set up apilot prospective cohort study to evaluate the relationship between chronic endometritis, infertility and endometriosis. The results of the study were recently…

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Endometriosis and susceptibility to COVID-19

Endometriosis and susceptibility to COVID-19 By Nasuhi Engin Aydin

Dr. Moazzami and associates from Pars Advanced and Minimally Invasive Medical Manners Research Center, Tehran, Iran have published their results on COVID-19 in endometriosis patients in the medical journal named "BMC’s Women’s Health". COVID-19 is still an emerging critical global health problem…

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A gentle touch on nerves affects dyspareunia

A gentle touch on nerves affects dyspareunia By Bahar Yuksel

Endometriosis is a common disorder among women. Previous studies reported endometriosis-related deterioration of the quality of life. Deep dyspareunia is a common symptom of endometriosis and young patients face dyspareunia twice as much. Surgical treatments are alternative to medical therapies in cases…

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Improvement of the quality of life after surgery for deep infiltrating endometriosis.

Improvement of the quality of life after surgery for deep infiltrating endometriosis. By Selma Oransay

Deeply infiltrating endometriosis is the most severe form among the endometriosis types. The required laparoscopic approach is the appropriate excision of endometriotic foci from pelvis, by consideration of failure and side effects of the medical treatments. The specialist endometriosis centers…

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Problems in the treatment of deep infiltrating endometriosis

Problems in the treatment of deep infiltrating endometriosis By Bahar Yuksel

The Deep Infiltrating Endometriosis (DIE) is very aggressive in nature with infiltrating the whole pelvic, colon, rectum, bladder, ureter, and pelvic wall. D’Alterio and colleagues analyzed the advantages and disadvantages of both medical and surgical therapies for DIE. The authors…

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Postoperative long-term estro-progestin therapy for endometrioma

Postoperative long-term estro-progestin therapy for endometrioma By Selma Oransay

After the removal of ovarian endometriomas, the major concern is the high recurrence rate of symptoms and endometriotic cysts. The estimated recurrence rate of endometriomas is up to 50% at 5 years after surgery. To prevent the recurrence, postoperatively long-term…

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Autophagy, Endometrium and Endometriosis

Autophagy, Endometrium and Endometriosis By Dr. Youngran Park

Autophagy, or autophagocytosis, is a self-digestion process by which cells recycle non-functional proteins to repurpose them. Unwanted cellular parts in cytosolic material are first isolated within double-membrane vesicles called the autophagosome, which subsequently fuses with the acidic lysosome. Autophagy is a survival…

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Immune-mediated conditions and endometriosis in adolescents and adults

Immune-mediated conditions and endometriosis in adolescents and adults By Hale Goksever Celik

The most common presenting complaints of endometriosis are mainly pelvic pain and infertility, commonly in relation to the menstrual period. Affected women demand therapy for these symptoms. Immunologic diseases such as autoimmune and/or inflammatory diseases, allergies, asthma, previous mononucleosis infection,…

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Testosterone levels effect embryo implantation rates in patients with endometriosis

Testosterone levels effect embryo implantation rates in patients with endometriosis By Bahar Yuksel

Endometriosis is associated with infertility either causing poor oocyte and embryo qualities or poor endometrial receptivity. The effect of androgen levels on IVF outcomes has been described earlier, but the present study conducted by Ling Huang et assocates is the…

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Fertilization rate and pregnancy outcome in IVF cycles of endometriosis.

Fertilization rate and pregnancy outcome in IVF cycles of endometriosis. By Selma Oransay

Endometriosis affects the pelvic cavity, uterus, ovaries and causes impaired fertility as a result. The chronic inflammatory nature of this disease negatively impacts the oocyte quality, maturation, and fertilization. Obviously, fewer oocytes can be harvested in the IVF cycles of…

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Adenomyosis: accuracy of the diagnostic methods and the synchronism with deep infiltrating endometriosis

Adenomyosis: accuracy of the diagnostic methods and the synchronism with deep infiltrating endometriosis By Nasuhi Engin Aydin

Dr. Alborzi and associates from Shiraz University of Medical Sciences, Iran, have published their comprehensive retrospective research conducted on 3725 patients with clinical symptoms of endometriosis over a period of 3 years, in "Reproductive Sciences" medical journal.  A relationship between…

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Can we measure the severity of endometriosis?

Can we measure the severity of endometriosis? By Dr. Youngran Park

Endometriosis is an enigmatic disease associated with serious morbidity and change in the quality of life. Unfortunately, there is no specific test for the diagnosis of endometriosis. While many markers were evaluated in many research studies for the noninvasive diagnosis…

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Postoperative treatment and pregnancy points to decreased recurrence risk for ovarian endometriosis

Postoperative treatment and pregnancy points to decreased recurrence risk for ovarian endometriosis By Hale Goksever Celik

Endometriosis is a disease most frequently diagnosed in women of reproductive age and negatively affects the quality of life. The most common localization for endometriosis is ovaries with a prevalence of 17-44%. Laparoscopic ovarian cystectomy performed as excision or ablation…

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Endometriosis, ART, fertility preservation

Endometriosis, ART, fertility preservation By Selma Oransay

This review entitled "The impact of endometriosis on the outcome of assisted reproductive techniques: role of fertility preservation" was written by Necula et al. from Gynecology and Obstetrics Unit, Biel, Switzerland, and recently published in the journal "Hormone, Molecular Biology and Clinical…

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Tubo-ovarian abscess and endometriosis

Tubo-ovarian abscess and endometriosis By Bahar Yuksel

A tubo-ovarian abscess is the result of pelvic inflammatory disease in women and the previous reports demonstrated that almost one of the third women with a pelvic inflammatory disease had a tubo-ovarian abscess. The main treatment modalities for tubo-ovarian abscess…

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Pain Sensitization and What Should Be Done About it?

Pain Sensitization and What Should Be Done About it? By Özge Özkaya

Pain sensitization and lumbopelvic impairments are common among women with endometriosis, especially if they have advanced stage disease. This is according to a study by researchers in Spain that was published in the scientific journal "Pain Medicine". The finding underscores the…

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Erastin, Ferroptosis and Endometriosis

Erastin, Ferroptosis and Endometriosis By Dr. Youngran Park

Iron overload has been linked to endometriosis. There are abundant free iron and high oxidation in ectopic lesions, probably due to retrograde menstruation. Interestingly, iron overload in endometriosis activates NF-kB signaling and results in proinflammatory communication. More clear pieces of…

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Cancer, is that a real risk?

Cancer, is that a real risk? By Yu Yu

Endometriosis is non-malignant but shares some similar features with cancer, such as the occurrence of local and distant foci, the ability to resist cell death, and the ability to invade other tissues, causing damage to the organs. Endometriosis also generates…

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Controlled use of bipolar cauterization as an alternative to endometrioma cystectomy

Controlled use of bipolar cauterization as an alternative to endometrioma cystectomy By Hale Goksever Celik

The main symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Ablation or coagulation of the cyst wall following laparoscopic drainage of endometrioma may be an alternative treatment for patients with pregnancy intention. Carbon dioxide, laser, and plasma energy…

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Perineal Endometriosis, How Soon Does it Return After Surgery?

Perineal Endometriosis, How Soon Does it Return After Surgery? By Özge Özkaya

The higher the body mass index (BMI) of a woman during delivery and within one month after delivery, the quicker the symptoms of perineal endometriosis return. This is according to a recent study that appeared in the World Journal of…

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The influence of endometrioma and surgery on ovarian reserve

The influence of endometrioma and surgery on ovarian reserve By Dr. Youngran Park

Women with endometriosis and endometrioma, often have subfertility. These patients present considerable problems for the evaluation of ovarian reserve. One of the well-known ovarian reserve biomarkers is anti-Müllerian hormone (AMH) levels. So far, it was known that the reduction of…

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Selected Blood Inflammatory Biomarkers May Help Identify Endometriosis

Selected Blood Inflammatory Biomarkers May Help Identify Endometriosis By Özge Özkaya

Levels of inflammatory biomarkers in the blood differ between women with endometriosis and those without the disease. Levels of some biomarkers also differ according to the stage of endometriosis. This is according to a new study by Polish scientists published…

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“Advanced gynecological ultrasound” for women with suspected endometriosis

“Advanced gynecological ultrasound” for women with suspected endometriosis By Hale Goksever Celik

Different clinical forms of endometriosis such as superficial endometriosis, endometrioma, and deep infiltrating endometriosis are present. Although no specific diagnostic tool is available for endometriosis, clinical findings, physical examination and imaging including transvaginal ultrasound and MRI are helpful to determine…

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Endometriosis and possible cardiovascular outcomes

Endometriosis and possible cardiovascular outcomes By Selma Oransay

A retrospective population-based cohort study from the Institute of Applied Health Research, University of Birmingham, Birmingham, the UK, investigated the long-term cardiovascular outcomes of women with endometriosis. The study included 279,759 women in total, 20,1% (>56.000) were patients with surgically…

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The effects of endometriosis on life satisfaction.

The effects of endometriosis on life satisfaction. By Bahar Yuksel

Endometriosis is well-known for its debilitating effects on women suffering from it. In the review conducted by Masoumeh Namazi et al, the authors have collected studies searching for the wellbeing of women with endometriosis. They have analyzed 46 studies that…

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Endometrial receptivity after the removal of ovarian endometriotic cysts

Endometrial receptivity after the removal of ovarian endometriotic cysts By Nasuhi Engin Aydin

Mikhaleva and associates from the "Russian Research Institute of Human Morphology" published their results in “Reproductive Sciences” yielding their novel morphological findings of eutopic endometria in patients following surgical excision of endometriotic ovarian cysts. Current therapeutic measures are targeting to…

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Managing the physical and emotional effects of endometriosis

Managing the physical and emotional effects of endometriosis By Hale Goksever Celik

Endometriosis is known to affect 5-10% of the general population, but some women are underdiagnosed due to physical and psychological disability. Due to the symptoms including dysmenorrhea, dyspareunia, chronic pelvic pain and infertility, endometriosis has a negative effect on the quality…

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Environmental to occupational exposure, and possible risk factors for endometriosis.

Environmental to occupational exposure, and possible risk factors for endometriosis. By Selma Oransay

Many objects in daily use are made of plasticizing agents. Studies suggest that chronic exposure to these agents are toxic to reproductive organs and cause metabolic disorders. For example, diethyl phthalate is still in use in cosmetic products.  Caporossi et…

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DNA damage response in eutopic endometria of endometriosis patients

DNA damage response in eutopic endometria of endometriosis patients By Dr. Youngran Park

The DNA damage response (DDR) is a network of cellular pathways that sense, signal, and repair the lesions occurring in DNA. Surveillance proteins that monitor DNA integrity activate the DNA repair pathways in response to DNA damage and try to prevent the generation of potentially deleterious mutations. Endometriosis is an estrogen-dependent…

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Impaired fertility potential in endometriosis patients

Impaired fertility potential in endometriosis patients By Hale Goksever Celik

Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis and sperm movements. Garcia-Fernandez and García-Velasco, from Edinburgh, UK and Madrid, Spain, published a mini-review titled “Endometriosis and Reproduction: What We Have…

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Oxygen deprivation (hypoxia) has a critical role in the pathogenesis and progression of endometriosis

Oxygen deprivation (hypoxia) has a critical role in the pathogenesis and progression of endometriosis By Nasuhi Engin Aydin

Dr. Wan-Ning Li and associates from academic institutions from Taiwan have published their review paper on the role of hypoxia and possible therapeutic outcomes in the medical journal named "Reproduction" recently.  Endometriosis is an important ailment with huge medical and social…

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Endometriosis and the risk of Systemic lupus Erythematosus: A report from Taiwan

Endometriosis and the risk of Systemic lupus Erythematosus: A report from Taiwan By Selma Oransay

Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage that affects mostly women, with an M:F ratio of 1:9. Recent evidence has also shown that endometriosis is…

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The incidence of endometriosis and pelvic pain in transgender man

The incidence of endometriosis and pelvic pain in transgender man By Bahar Yuksel

Transgender operations are quite common all around the world and hysterectomies are performed almost 1 in 5 of this population. The studies conducted until now mostly evaluated operative and postoperative outcomes, but the present research also questioned the preoperative symptoms and…

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Nanomedicines for Endometriosis

Nanomedicines for Endometriosis By Dr. Youngran Park

Scientific research on nanoparticles is intense as they have many potential applications in medicine. Nanomaterials have been widely explored for imaging and treatment of various diseases, especially cancer, over the recent twenty years.  The absence of non-invasive diagnostic tests and…

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The improvement of fertility rate and symptoms of superficial endometriosis following laparoscopic peritoneal stripping

The improvement of fertility rate and symptoms of superficial endometriosis following laparoscopic peritoneal stripping By Selma Oransay

Pain, in the form of diverse entities, including dyspareunia, dysuria, dyschezia, is the main symptom of endometriosis patients. The severity of pain is independent of the extent and the location of the disease, and generally causes a negative impact on…

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Vitamin D supplementation, endometriosis symptoms and metabolic profiles

Vitamin D supplementation, endometriosis symptoms and metabolic profiles By Hale Goksever Celik

Patients with endometriosis suffer from dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. These women are also at higher risk for ovarian and breast cancer, cardiovascular events, and metabolic abnormalities. Several medical and surgical alternatives have been recommended to these patients…

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Cancer risk Evaluation in Korean Endometriosis Cohort

Cancer risk Evaluation in Korean Endometriosis Cohort By Bahar Yuksel

The relationship between endometriosis and cancer has always been challenging. The previous studies revealed an increased risk in endometriosis-associated ovarian cancers regarding the alterations in cancerogenic genes or by the effect of iron and hem coming with retrograde menstruation and…

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A comparison of symptomatology and histopathologic features in surgically resected colorectal endometriosis

A comparison of symptomatology and histopathologic features in surgically resected colorectal endometriosis By Nasuhi Engin Aydin

Dr. Tschan and associates from Feldrich Academic Teaching Hospital, Austria published their retrospective research on patients requiring colorectal surgical resection for endometriosis in European Journal of Medical Research. Bowel endometriosis requiring colorectal surgical resection causes important morbidity. The rectum and…

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Antioxidant therapy for the endometriosis pain

Antioxidant therapy for the endometriosis pain By Selma Oransay

Ts the protective defense mechanism of cells, hence the destruction of balance between oxidants and antioxidants in our body is called "redox imbalance".  The major oxidants are reactive oxygen species (ROS) that are involved in multiple cellular processes by physiologically…

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Ovarian, breast and endometrial cancer coexisting with endometriosis.

Ovarian, breast and endometrial cancer coexisting with endometriosis. By Selma Oransay

The invasive nature of endometriosis results in calling the disease " benign cancer". The transformation of endometriosis to malignancy is rare, but when compared to the general population, the relative risk of developing ovarian cancer is 4.2 times greater especially…

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Self-management and the quality of life in women with endometriosis

Self-management and the quality of life in women with endometriosis By Hale Goksever Celik

Endometriosis symptoms can range from mild to severe. The most common presenting complaints are mainly pelvic pain and infertility. There is no doubt that the physical and mental quality of life of these women is adversely affected. There are several studies…

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The role of hormonal treatment after endometriosis surgery

The role of hormonal treatment after endometriosis surgery By Bahar Yuksel

Postoperative hormonal suppression after endometriosis surgery still does not have a uniform approach. The meta-analysis study conducted by Zakhari et al. aimed to find a significant answer regarding this burden. They analyzed the database systems including MEDLINE, Embase, Cochrane CENTRAL,…

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The association between body size and endometriosis

The association between body size and endometriosis By Irem Onur

Until today there have been few studies investigating body size in childhood and adolescence in women with endometriosis. A new study published recently in the journal Acta Obstetricia et Gynecologica Scandinavica provides further evidence of the associations between endometriosis, body…

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"Speckle sign": a novel transvaginal ultrasound finding for posterior compartment endometriosis

By Nasuhi Engin Aydin

Dr. Balcacer and associates from three medical institutions located in the USA report the results of their retrospective study on deep infiltrating endometriosis utilizing transvaginal ultrasound examination and the proposed  “speckle sign” in the "Journal of Ultrasound Medicine". Pelvic ultrasound…

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Oxidative stress, reactive products, detoxification, endometriosis and pain

Oxidative stress, reactive products, detoxification, endometriosis and pain  By Ellen Tumimbang

Oxidative stress is one factor known to be involved in the pathogenesis, progression, and establishment of endometriosis in women.   During oxidative stress, excess reactive oxygen species as a secondary by-product of lipid peroxidation and reactive aldehyde including 4- hydroxynonenal…

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Live Birth Rate in Women Who Underwent Fresh Embryo Transfer Using Freshly Retrieved Donor Oocytes

Live Birth Rate in Women Who Underwent Fresh Embryo Transfer Using Freshly Retrieved Donor Oocytes By Hale Goksever Celik

One of the important clinical findings in women with endometriosis is reproductive problems. Infertility can be encountered in up to 50% of women with endometriosis and up to 50% of women with infertility can be diagnosed with endometriosis. Several pathophysiologic…

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What is the cause of Dienogest-resistance in patients with endometrioma?

 What is the cause of Dienogest-resistance in patients with endometrioma? By Selma Oransay

Endometriosis may cause infertility in women, leading to adhesions in the pelvis, besides affecting the ovaries. Clinicians concern about the child-bearing desire of their patients when treating them surgically or with hormonal therapy. Dienogest (DNG) is a kind of progestin,…

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Time for noninvasive serum markers for endometriosis diagnosis

Time for noninvasive serum markers for endometriosis diagnosis By Nasuhi Engin Aydin

Dr. Onur Guralp and associates from Germany and Turkey published their results on serum markers predicting endometriosis in the "Journal of Obstetrics and Gynaecology".   Still, in 21st-century medicine, doctors can not diagnose endometriosis using biochemical serum markers. Proposed serum markers…

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Analysis of women with endometriosis-related pain before the multidisciplinary endometriosis care management

Analysis of women with endometriosis-related pain before the multidisciplinary endometriosis care management By Irem Onur

Endometriosis patients are generally treated by a single provider and they frequently report dissatisfaction with care. To decrease diagnostic delays, improve pain management, and promote patient satisfaction, multidisciplinary endometriosis centers emerged. But, baseline data assessing the efficacy of the multidisciplinary…

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High-dose progestin intake and sexual functions in endometriosis patients

High-dose progestin intake and sexual functions in endometriosis patients By Selma Oransay

Dr. Oppenheimer et al. from the Department of Reproductive Medicine and Fertility Preservation of Antoine Beclere University Hospital, Clamart, France, recently published this bi-center observational prospective study in "Acta Obstetrica et Gynecologica Scandinavica". The study was designed to put forth…

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Endometriosis, Fatigue and Productivity

 Endometriosis, Fatigue and Productivity By Ellen Tumimbang

Fatigue is one of the prominent and distressing symptoms of endometriosis-associated with insomnia, depression, pain, occupational stress, and reduced health-related quality of life. Endometriosis-related fatigue causes significant impairments in workplace productivity and daily activities of women with endometriosis. Loss of…

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Postoperative pregnancy rate in infertile women with deep infiltrating endometriosis

 Postoperative pregnancy rate in infertile women with deep infiltrating endometriosis By Hale Goksever Celik

Deep infiltrating endometriosis (DIE) is fibrous/muscular infiltration of organs and anatomical structures containing endometrial tissue below the peritoneum regardless of the depth of infiltration. Another definition describes DIE as infiltration of the peritoneum by endometriotic lesions deeper than 5 mm. Pain,…

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Deep endometriosis treatment options based on the patient's decision

 Deep endometriosis treatment options based on the patient's decision By Selma Oransay

Deep endometriosis, defined as endometriotic lesions penetrating deeper than 5 mm into the peritoneum comprise approximately 20% of all endometriosis cases. This invasive disease causes a significant reduction in the quality of life, social participation, and sexual health of affected…

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KEYNOTE: Excision Without Mutilation: It’s Possible! -  Arnaud Wattiez, MD

KEYNOTE: Excision Without Mutilation: It’s Possible! -  Arnaud Wattiez, MD By Özge Özkaya

In his keynote lecture, Dr. Wattiez talks about the pros and cons of endometriosis surgery and the importance of tailoring endometriosis surgery to individual patients.  “Endometriosis is a disease that degrades patient’s wellbeing," Dr. Wattiez says and gives some examples…

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Exploring the Role of Neuropathy in Re-Operative Endometriosis - Marc Possover, MD, PhD

Exploring the Role of Neuropathy in Re-Operative Endometriosis - Marc Possover, MD, PhD By Özge Özkaya

Prof. Possover starts his presentation by summarizing the possible cause of pelvic neuropathy following endometriosis surgery. Pelvic neuropathy is the damage or dysfunction of the pelvic nerve. Prof. Possover explained that this could either be due to incomplete surgery, disease…

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Operative techniques for Deep Endometriosis Surgery - Shaheen Khazali, MD

Operative techniques for Deep Endometriosis Surgery - Shaheen Khazali, MD By Özge Özkaya

In this presentation, Dr. Shaheen Khazali, an endometriosis surgeon specialized in gastrointestinal and urinary tract endometriosis excision and in neuropelveology, talks about the general principles and some techniques for endometriosis surgery focusing on rectovaginal endometriosis. He also describes the "ten…

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Laparoscopic Approach to Rectus Muscle Endometriosis and Inguinal Endometriosis - Ted Lee, MD

Laparoscopic Approach to Rectus Muscle Endometriosis and Inguinal Endometriosis - Ted Lee, MD By Selma Oransay

Rectus muscle endometriosis and inguinal endometriosis are two rare types of endometriosis. Operation room videos of several patients with different rectus muscle endometriosis and inguinal endometriosis are shared during the presentation of Dr. Lee to clarify the methods of the…

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Separation of epithelia and stroma components in endometriosis lesions yields remarkable molecular points - Ie-Ming Shih, MD, Ph.D.

Separation of epithelia and stroma components in endometriosis lesions yields remarkable molecular points - Ie-Ming Shih, MD, Ph.D. By Nasuhi Engin Aydin

The pathologies of adenomyosis and endometriosis are unique among non-malignant gynecological diseases and provide fertile research topics. Ectopic endometrial tissues may have distinct molecular changes distinct from eutopic endometria despite having similar morphology. In this regard, there are intriguing suggestions as…

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Exploring Pelvic Pain: Deep to Ischial Spine Including Pre-Sacral Roots - A. Taner Usta, MD

Exploring Pelvic Pain: Deep to Ischial Spine Including Pre-Sacral Roots - A. Taner Usta, MD By Irem Onur

Chronic pelvic pain is defined as pain in the pelvic area that lasts for 6 months or longer and results in functional or psychological disability or requires intervention and treatment by the American College of Obstetrics and Gynecologists. There are…

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Why Persistent or Recurrent Endometriosis Happens? - Dan Martin, MD

Why Persistent or Recurrent Endometriosis Happens? - Dan Martin, MD By Ellen Tumimbang

The objectives of Dr. Martin in this presentation are to understand the difficulties in recognition of deep and hidden endometriosis, difficulties in recognition of small lesions of micron size, and differentiate the look-alike lesions of endometriosis. He addressed overcoming these…

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Role of Prophylactic Oophorectomy in Endometriosis Patients with Ovarian Cancer History in the family - Farr Nezhat, MD

Role of Prophylactic Oophorectomy in Endometriosis Patients with Ovarian Cancer History in the family - Farr Nezhat, MD By Özge Özkaya

Dr. Nezhat starts his presentation by outlining his objectives, which are to review the basics of cancer genetics, give an overview about endometriosis and ovarian cancer, discuss the pathogenesis of malignant transformation of endometriosis, and talk about the clinical implications…

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Further Evidence that endometriosis is related to tubal or ovarian cancer - Togas Tulandi, MD

Further Evidence that endometriosis is related to tubal or ovarian cancer - Togas Tulandi, MD By Selma Oransay

Most authors suggest an association of endometriosis mainly with clear cell, low-grade serous, and endometrioid ovarian cancer.  But in two large cohort studies, no correlation between them is reported (Olson et al. 2002 and Tseng et al. 2019) Dr. Tulandi…

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Insoluble Dilemma of Adenomyosis: Diagnosis, Management, and Treatment  - Errico Zupi, MD

Insoluble Dilemma of Adenomyosis: Diagnosis, Management, and Treatment  - Errico Zupi, MD By Selma Oransay

The prevalence of adenomyosis has been reported to range from 1% to 70% in different studies. This large range can be explained by the lack of standard diagnostic criteria by imaging modalities or pathological analyses. Sixty-five% of the women with adenomyosis…

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It is time for redefining endometriosis with our contemporary scientific knowledge - Philippe Koninckx, MD, Ph.D.

It is time for redefining endometriosis with our contemporary scientific knowledge -  Philippe Koninckx, MD, Ph.D. By Nasuhi Engin Aydin

Endometriosis defined as endometrium-like tissue outside the uterus has a poorly understood natural history. It is a heterogeneous disease having genetic-epigenetic features with many biochemical changes in the lesions. The Sampson hypothesis of implanted endometrial cells following retrograde menstruation is not…

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Urological Challenges in Endometriosis Surgery - Guenter Noe, MD

Urological Challenges in Endometriosis Surgery - Guenter Noe, MD By Özge Özkaya

In this presentation, Dr. Guenter Noé, Head of Department of Rheilandklinikum Dormagen in Germany talks about endometriosis affecting the urinary tract. Dr. Noé starts by describing the different parts of the urinary tract that can be affected by endometriosis including…

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Implantation failure in endometriosis patients - Jovana Lekovich, MD., PhD.

Implantation failure in endometriosis patients - Jovana Lekovich, MD., PhD. By Hale Goksever Celik

Endometriosis is one of the leading reasons for infertility due to decreased oocyte/embryo quality, fertilization ability, tubal function, and aberrant endometrial receptivity. Whether this failure is caused by oocyte/embryo or eutopic endometrium is one of the investigated topics in endometriosis…

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Fixing holes: prevention and treatment of complications - Jon Einarsson, MD, MPH

Fixing holes: prevention and treatment of complications - Jon Einarsson, MD, MPH By Selma Oransay

Dr. Einarsson shared his operating room video screens during his speech for discussing four major complications (ureter, bladder,  bowel, and vascular) of endometriosis surgery and the ways to repair them. Fixing the ureter damage: Endometriotic nodules may settle on the tract…

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Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD

Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD By Selma Oransay

The removal of endometrioma may affect ovarian reserve because healthy follicles near endometrioma could also be excised during this procedure. Another concern about the ovarian reserve is that it may be already low before the surgery. Anti Mullerian Hormone (AMH)…

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In vitro fertilization protocols in endometriosis patients - Pinar Kodaman, MD., PhD.

In vitro fertilization protocols in endometriosis patients - Pinar Kodaman, MD., PhD. By Hale Goksever Celik

Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis, and sperm movements. Even though the disease stage and presence of endometrioma is negatively correlated with infertility, it is unpredictable which women…

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Could Cosmetics and Personal Care Products Increase the Risk of Endometriosis?

Could Cosmetics and Personal Care Products Increase the Risk of Endometriosis? By Özge Özkaya

The use of cosmetics and personal care products may be increasing the risk of endometriosis according to a study by Spanish researchers that was published in the journal "Environmental Research". This finding suggests that restricting the use of these products may…

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Endometriosis and the sexual relations of the couples

Endometriosis and  the sexual relations of the couples By Selma Oransay

From the viewpoint of endometriotic women, the pain during the penetration is not the only complaint. They also have growing depression and anxiety leading to difficulties with their social and sexual relationship, work, and study. The emotional impact of sub-infertility,…

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A Possible genetic target for endometriosis treatment

A Possible genetic target for endometriosis treatment By Dr. Youngran Park

Mutations in the chromosome remodeling complex SWI/SNF subunit ARID1A were first identified in ovarian clear-cell carcinoma and ovarian endometrioid carcinoma, two endometriosis-associated epithelial ovarian cancer subtypes. ARID1A gene mutations are also observed in deep ovarian and deep infiltrating endometriosis, atypical endometrial…

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Endometriosis involving the Sacral Plexus and Sciatic Nerve

Endometriosis involving the Sacral Plexus and Sciatic Nerve By Irem Onur

Endometriosis rarely involves the sacral and sciatic nerves. A retrospective analysis led by Rouen University Hospital, France and Aarhus University Hospital, Denmark, published in the Journal of Minimally Invasive Gynecology, has evaluated preoperative complaints, intraoperative findings, surgical procedures, and postoperative…

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Endometrioma size and anti-Müllerian hormone levels

Endometrioma size and anti-Müllerian hormone levels By Hale Goksever Celik

Endometriotic lesions are encountered in different locations in the pelvic cavity, including but not limited to the ovaries, the pouch of Douglas, the ureters, the bladder, and the bowel. Cystic endometriosis lesions located in the ovary are called "endometrioma". Endometriomas have…

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Does hysterectomy bring a total relief in patients with endometriosis?

Does hysterectomy bring a total relief in patients with endometriosis? By Bahar Yuksel

There is a common belief that hysterectomy is the last option to relieve the pain in patients with endometriosis by stopping the production of menstrual material. The study entitled "Impact of hysterectomy on analgesic, psychoactive and neuroactive drug use in…

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Pelvic MRI, Endometriosis and Radiologist

Pelvic MRI, Endometriosis and Radiologist By Murat Osman

Endometriosis is a condition whereby ectopic endometrial cells implant themselves onto other structures within the body. Depending on where these lesions are, their size, and if they cause symptoms, surgical intervention may be warranted. Although the gold standard for diagnosing…

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How to unveil the discrepancy regarding the effect of chemicals on the etiology of endometriosis

How to unveil the discrepancy regarding the effect of chemicals on the etiology of endometriosis By Nasuhi Engin Aydin

Kristen Upson from Michigan State University published a review article evaluating research papers on environmental factors effective in endometriosis from an epidemiological perspective in "Current Epidemiology Reports". Endometriosis is a multifactorial disease with anatomical, hormonal, immunological, estrogenic, genetic, epigenetic, and…

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Endometriosis and chronic opioid use

Endometriosis and chronic opioid use By Selma Oransay

The members of the American College of Obstetricians and Gynecologists have declared that gynecologists prescribe opioids after laparoscopic hysterectomy, or for relieving endometriosis pain, although guidelines are not available for when or how to use opioids for the treatment of endometriosis-associated…

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Adolescent endometriosis: Diagnostic clues?

Adolescent endometriosis: Diagnostic clues? By Irem Onur

The rates of dysmenorrhea, dyspareunia, and heavy menstrual bleeding in adolescents showing endometriosis signs on ultrasound are significantly higher compared to those without. This is according to a retrospective observational study recently published in the journal "Fertility and Sterility". The…

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Reduced risk of "small for gestational age baby" following frozen embryo transfer in endometriosis patients

Reduced risk of By Hale Goksever Celik

Infertility is encountered frequently in patients with endometriosis. These women could be managed using assisted reproductive technology (ART) including in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) to achieve pregnancy. However, some adverse obstetric and perinatal outcomes are experienced more…

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Endometrial fluid analysis as a new diagnostic test for endometriosis diagnosis

Endometrial fluid analysis as a new diagnostic test for endometriosis diagnosis By Bahar Yuksel

There is still a huge demand for finding a minimally invasive diagnostic test for endometriosis and yet none has been defined properly. The present study which was conducted in Cleveland Clinic by Natalia C. Llarena et al between March 2017…

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Comparison of diagnostic accuracy of imaging modalities for the deep infiltrating endometriosis

Comparison of diagnostic accuracy of imaging modalities for the deep infiltrating endometriosis By Selma Oransay

The treatment of deeply infiltrated endometriosis (DIE) is usually personalized and the potential success for the available therapeutical options is dependent on early and accurate diagnosis. Laparoscopy is the gold standard for the diagnosis of DIE. Other non-invasive diagnostic methods…

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Endometriosis and adenomyosis could be the “sides of the same coin”.

Endometriosis and adenomyosis could be the “sides of the same coin”. By Nasuhi Engin Aydin

The two common gynecological disorders, namely adenomyosis, and endometriosis are not settled yet, whether they are representing two different entities or different phenotypes of the same ailment. Dr. Maruyama and colleagues from Nara, Japan searched PubMed and Google Scholar electronic…

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Endometriosis and Natural Killer Cell Immunity

Endometriosis and Natural Killer Cell Immunity By Dr. Youngran Park

It is known that approximately 25 to 50% of infertile women have endometriosis, and 30% to 50% of the women with endometriosis have infertility and recurrent pregnancy loss. Previous studies have shown that women suffering endometriosis have abnormal NK cell…

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Magnetic resonance imaging classification for the management of deep pelvic endometriosis

Magnetic resonance imaging classification for the management of deep pelvic endometriosis By Irem Onur

A new study published in the journal "Human Reproduction" reported that operating time, hospital stay, and postoperative complications in patients who underwent surgery for deep endometriosis can be predicted by the MRI. This result may be useful for clinicians to…

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Combination of noninvasive biomarkers in the identification of endometriosis

Combination of noninvasive biomarkers in the identification of endometriosis By Timur Seckin

The combined measurement of urine enolase, serum CA125, and CA19-9 may be an accurate test for the prediction and detection of endometriosis. This is according to a study published in the journal BioMedical Research International. The gold standard for the…

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Patients' opinion about surgical treatment of endometriosis

Patients' opinion about surgical treatment of endometriosis By Selma Oransay

Delayed diagnosis and management of endometriosis and chronic pelvic pain is a major problem in gynecologic practice. Alternatively, providers may feel reluctant to perform surgery although they are aware of treatment options and surgical timing. One possible reason for this…

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Segmental bowel resection could be predicted using MRI in patients with rectal endometriosis

Segmental bowel resection could be predicted using MRI in patients with rectal endometriosis By Hale Goksever Celik

The rectum and recto-sigmoid junction are the preferential localisations of bowel endometriosis. The three main surgical approaches are shaving, disc excision, and segmental resection. It is very important to decide the most appropriate surgical method preoperatively and to plan accordingly. …

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Can a grape ingredient, resveratrol, be the promised warrior to defeat endometriosis?

Can a grape ingredient, resveratrol, be the promised warrior to defeat endometriosis? By Bahar Yuksel

Endometriosis is a chronic estrogen-dependent disorder and has a known relationship with angiogenesis, inflammation, and oxidative stress. Resveratrol is a part of a "polyphenol" compound which are thought to act like antioxidants, protects the body against damage. This compound is normally…

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Dyspareunia and Endometriosis

Dyspareunia and Endometriosis By Irem Onur

Women experience severe pain during intercourse related to endometriosis and this has a significant negative impact on the lives of women. This is according to an American study published in the "Journal of Pain Research". The study included 638 endometriosis…

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Bad bad lipid go away!

Bad bad lipid go away! By Yu Yu

Much like the progression of endometriosis, accumulating evidence suggests that systemic chronic inflammation and oxidative stress can contribute to atherosclerosis. The excess low-density lipoprotein increases inflammatory processes in the arteries, which may result in atherosclerosis. Previous studies have shown that…

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Indocyanine green in endometriosis surgery

Indocyanine green in endometriosis surgery By Selma Oransay

Recently, indocyanine green is well studied and used safely in real-time perfusion to organs or tissues, after taking into consideration its binding capacity to the plasma proteins. The usefulness and the effectiveness of near-infrared camera guided indocyanine green is proved with…

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Osteopontin and Endometriosis

Osteopontin and Endometriosis By Dr. Youngran Park

Although characterized as a benign disease, some properties of endometriosis mimic malignant tissues such as proliferation, cell invasion, and metastasis. Osteopontin, also called secreted phosphoprotein 1, is one of the important molecular targets in cancer progression and metastasis. Osteopontin has been…

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It is time for non-invasive tests for peritoneal endometriosis diagnosis

It is time for non-invasive tests for peritoneal endometriosis diagnosis By Nasuhi Engin Aydin

Maria Szubert with colleagues from Lodz Medical University, Poland, investigated the possibility of potential diagnostic biomarkers in the eutopic endometrial tissue from peritoneal endometriosis patients and published their results in the "Journal of Gynecology Obstetrics and Human Reproduction". Currently, diagnostic…

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Psychometric properties of Endometriosis Health survey-Swedish version

Psychometric properties of Endometriosis Health survey-Swedish version By Hale Goksever Celik

Endometriosis is a chronic estrogen-dependent disease resulting in a broad spectrum of symptoms and signs including dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Additionally, gastrointestinal and urinary systems may be affected by this disease. All of these clinical findings impair…

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Fallopian tube endometriosis

Fallopian tube endometriosis By Bahar Yuksel

Endometriosis affects various tissues including pelvic and extra-pelvic organs. Fallopian tube endometriosis is not a widely studied topic in endometriosis, hence the real incidence is unknown as not all studies evaluate microscopically diagnosed Fallopian tube endometriosis. In the retrospective database…

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Non-coding RNAs and Endometriosis

Non-coding RNAs and Endometriosis By Ellen Tumimbang

Non-coding RNAs may have a fundamental role in the development of endometriosis. Non-coding transcripts have regulatory roles in the expression of protein-coding genes, thus regulate several signaling pathways. Based on their length, these non-coding RNAs are classified into two main classes:…

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Body mass index, the incidence of endometriosis and the severity of dysmenorrhoea

Body mass index, the incidence of endometriosis and the severity of dysmenorrhoea By Timur Seckin

According to a case-control study conducted by researchers from China, there is no association between body mass index (BMI) and the incidence of endometriosis. This finding contrasts with the conventional knowledge that low BMI is a risk factor for endometriosis.…

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An animal model of endometriosis reveals stress related disturbed vitamin D - vitamin D receptor axis

An animal model of endometriosis reveals stress related disturbed vitamin D - vitamin D receptor axis By Nasuhi Engin Aydin

Lopez and colleagues from academic institutions of Puerto Rico published their experimental endometriosis findings on female rats regarding the effect of stress on vitamin D-vitamin D receptor systems and recently published their findings in "Reproductive Sciences". The group previously showed…

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The peculiarity of adolescent endometriosis

The peculiarity of adolescent endometriosis By Selma Oransay

Recent studies showed the prevalence of endometriosis in adolescents with chronic cyclic or acyclic pelvic pain is about 60-70%. Moreover, all stages of endometriosis, including deeply infiltrating endometriosis can be found in this population. Gubbels et al. from the Department…

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The intensity of pelvic pain is higher in endometriosis patients

The intensity of pelvic pain is higher in endometriosis patients By Irem Onur

Silva  J.B. et al., researchers from Brazil, conducted a case-control study to determine the intensity of clinical pain, the average body composition, and the anthropometric markers including the body mass index, the perimeters (waist, abdomen, hip), and the percentage of…

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The more than expected prevalence of endometriosis in patients with Mullerian abnormalities

The more than expected prevalence of endometriosis in patients with Mullerian abnormalities By Bahar Yuksel

Congenital müllerian anomalies resulting in a spectrum of uterine abnormalities are caused by the abnormal embryologic fusion of the müllerian ducts to form a normal uterine cavity.  They are often unrecognized because they are usually asymptomatic. The presence of a uterine…

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Depression and anxiety levels in "in vitro fertilization" patients with endometriosis

Depression and anxiety levels in By Hale Goksever Celik

Endometriosis is a reproductive-aged and estrogen-dependent disease. The most common symptoms of this disease are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility affecting the quality of life in several aspects mainly the psychological domain. In the literature, there are many studies…

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Endometriosis-related obstetrical complications and their outcome

Endometriosis-related obstetrical complications and their outcome By Selma Oransay

Borisova et al. from the Department of Gynecology and Obstetrics of Peoples' Friendship University, Moskow, Russia, and her colleagues from the Center of Perinatal and Reproductive Medicine of University Perugia, Italy, recently published a review of the literature data about…

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Time for reassessment : Laparoscopic surgery and bowel endometriosis

Time for reassessment : Laparoscopic surgery and bowel endometriosis By Nasuhi Engin Aydin

Ferrero and associates from medical centers of Verona and Genoa, Italy, made a comprehensive review covering all aspects of the surgical approach to bowel endometriosis, published their results in "Best Practice & Research Clinical Obstetrics and Gynaecology". Bowel endometriosis is the…

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Cellular communications: Exosomes in Endometriosis

Cellular communications: Exosomes in Endometriosis By Dr. Youngran Park

Exosomes have been reported as cell-to-cell communicators, transfer many molecules such as miRNAs, RNAs, and proteins, and their alteration may cause many disease processes, including endometriosis. Considering the role of exosomes and their cargos in a cell to cell communication as important…

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Predictors of voiding dysfunction after surgery for deep endometriosis

Predictors of voiding dysfunction after surgery for deep endometriosis By Selma Oransay

While surgery for deep endometriosis provides relief and improves the quality of life in symptomatic patients for whom medical therapy has limited effect, it may also create postoperative lower urinary tract dysfunction. Moreover, postoperative voiding dysfunction could affect the quality…

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Sleep Quality, Lifestyle Factors and Endometriosis

Sleep Quality, Lifestyle Factors and Endometriosis By Hale Goksever Celik

Endometriosis does not only affect the patients by dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. An important issue in these patients, like other chronic diseases, is sleep quality. Youseflu et al., from Iran, published a study entitled “Effects of endometriosis…

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Colorectal Deep Endometriosis Resection and Potential Complications

Colorectal Deep Endometriosis Resection and Potential Complications By Murat Osman

A severe clinical form of endometriosis, deeply infiltrating endometriosis (DIE) is characterized by more aggressive endometriotic lesions commonly involving deeper pelvic or gastrointestinal organs. It causes significant quality of life impairment and morbidity and is increasingly associated with infertility. When…

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Factors affecting the quality of life of women with endometriosis

Factors affecting the quality of life of women with endometriosis By Timur Seckin

Results from a new study suggest that the quality of life of women with endometriosis is significantly affected by their confidence to manage pain and their belief in the evolution of their condition. In this study, led by Rees M. et…

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Deep Endometriosis or Recto-uterine Obliteration Without Endometrioma

Deep Endometriosis or Recto-uterine Obliteration Without Endometrioma By Selma Oransay

The diagnostic help of ultrasound is increasing by its ability to diagnose deep infiltrating and rectouterine pouch obliteration in patients who are suffering from chronic pelvic pain. Clinicians are used to evaluating the rectal and parametrial areas of the endometriotic…

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Antioxidant Enzymes in Endometriosis

Antioxidant Enzymes in Endometriosis By Dr. Youngran Park

Recent attention has been focused on the effect of oxidative stress in the development of endometriosis. Especially, there are several studies regarding glutathione peroxidase (GPX), a major enzyme in removing various reactive oxygen species. In the field of infertility, the…

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The advantages of combined vaginal-laparoscopic approach on voiding dysfunction for rectovaginal endometriosis

The advantages of combined vaginal-laparoscopic approach on voiding dysfunction for rectovaginal endometriosis By Irem Onur

The patients with rectovaginal endometriotic nodules with extensive vaginal infiltration who are managed combined vaginal-laparoscopic approach have a lower risk of postoperative bladder dysfunction when compared to surgery via laparoscopy alone. This is according to a manuscript published in the…

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Inhibiting killer on the move

Inhibiting killer on the move By Yu Yu

The three main forms of endometriosis are superficial, ovarian, and deep endometriosis. The latter is defined by the presence of endometriotic nodules that are deeper than 5 mm. Deep endometriosis is considered the most aggressive and is associated with severe…

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Endometrial polyps of patients with and without endometriosis

Endometrial polyps of patients with and without endometriosis By Nasuhi Engin Aydin

Endometrial polyps are benign local overgrowths comprising both glands and the stroma, and are quite common in gynecological practice. Endometriosis patients also commonly have polyps, which have yielded different features than those from patients without endometriosis.  Dr. Jiangand and associates…

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The impact of laser vaporization on reproductive outcomes in women with endometrioma

The impact of laser vaporization on reproductive outcomes in women with endometrioma By Hale Goksever Celik

Despite extensive research, the optimal method for the management of endometriosis still remains unclear. Excisional surgery is claimed with a more favorable outcome than drainage and ablation regarding the recurrence of disease and symptoms. On the other hand, cyst vaporization…

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A Call for Pan-Canadian Collaboration for the Care and Quality of Life of Endometriosis Patients

A Call for Pan-Canadian Collaboration for the Care and Quality of Life of Endometriosis Patients By Timur Seckin

Wahl KJ et al., from Canada, drew attention to the lack of health care for endometriosis patients who are estimated to be 1 million in number in Canada in their recent brief communication report. The delay in the diagnosis, the…

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Bowel surgery for endometriosis

Bowel surgery for endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. The disease harbors various complications. Deep endometriosis involving the bowel is only one aspect of the condition that has variable phenotypic presentations and pathologic subtypes. Knowledge of the short- and long-term risks of the surgical…

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Benefits of Nerve-Sparing Hysterectomy

Benefits of Nerve-Sparing Hysterectomy By Selma Oransay

The retroperitoneal spread of endometriosis or cancer may involve pelvic autonomic nerves situated on the lateral aspects of uterosacral ligaments, vesicouterine ligaments, and medial aspects of parametria. During the conventional open hysterectomy operations, nerve-sparing excision is very difficult, simply because pelvic autonomic nerves…

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Mental stress promotes mice endometriosis

Mental stress promotes mice endometriosis By Bahar Yuksel

Endometriosis is a disease for which pathogenesis and progression are not fully understood. Inflammation is one of the key candidates that might be related to the creation or progression of endometriosis. In the study conducted by Kawakita et al from…

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Diagnosis and treatment of endometriosis in adolescents

Diagnosis and treatment of endometriosis in adolescents By Irem Onur

The belief that dysmenorrhea, the primary symptom of endometriosis, in adolescents is an inevitable condition seen in menstruation as well as unwillingness to perform diagnostic laparoscopy may cause the delay of diagnosis of endometriosis. This is according to a recent…

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Natural history of spontaneous endometriosis in crab-eating monkeys

Natural history of spontaneous endometriosis in crab-eating monkeys By Nasuhi Engin Aydin

Kaori Hayashi and associates from Shiga University of Medical Science, Japan, published their observations on spontaneously occurring endometriosis in crab-eating monkeys in "Tohoku Journal of Experimental Medicine"https://www.jstage.jst.go.jp/article/tjem/251/4/251_241/_pdf/-char/en. The presence of endometrial tissue outside the uterus, i.e., endometriosis is a progressive prevalent…

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Is there a commonality between endometriosis and systemic lupus?

Is there a commonality between endometriosis and systemic lupus? By Murat Osman

Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect many organs including the skin, joints, the central nervous system, and the kidneys. Women of childbearing age and certain racial groups are at increased risk to develop the condition.…

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Patient-centered care in patients with endometriosis

Patient-centered care in patients with endometriosis By Hale Goksever Celik

The women with endometriosis suffer from several symptoms and signs including dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility which have a detrimental effect on their quality of life. Endometriosis is diagnosed with 7-10 years of delay due to the absence…

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Immune cells and endometriosis pain

Immune cells and endometriosis pain By Dr. Youngran Park

Endometriosis is an estrogen-dependent inflammatory disorder in women. This disease leads to dysmenorrhea, pelvic pain, and infertility. The immune reaction is one of the most widely accepted pathologies of endometriosis. Estrogen dysfunction stimulates immune cells in the peritoneal cavity affecting…

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Voiding Dysfunction after Colorectal Surgery for Endometriosis

Voiding Dysfunction after Colorectal Surgery for Endometriosis By Timur Seckin

Postoperative voiding dysfunction is a less frequent complication of rectal shaving than that of discoid excision or segmental resection in patients undergoing colorectal surgery for endometriosis, regardless of its definition. This is according to a meta-analysis conducted by researchers from…

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Prevalence, Risk factors and Management of Bowel Fistula after Rectosigmoid Surgery for Deep Endometriosis

Prevalence, Risk factors and Management of Bowel Fistula after Rectosigmoid Surgery for Deep Endometriosis By Selma Oransay

Bowel fistula is a severe complication after the colorectal endometriosis surgery, but little is known about its prevalence, and reports on large series are lacking. To discuss specific management on colorectal deep endometriosis, Roman et al. conducted a retrospective study…

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Endometriosis prevalence among adolescents with pelvic pain

Endometriosis prevalence among adolescents with pelvic pain By Irem Onur

An updated review conducted by the investigators at EGA Institute for Women's Health, University College London, United Kingdom, in collaboration with Birmingham Women’s and Children’s Foundation Trust of the Institute of Metabolism and Systems Research at the University of Birmingham…

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Reproductive capacity and recurrence rate after surgery for Stage III/IV endometriosis 

Reproductive capacity and recurrence rate after surgery for Stage III/IV endometriosis  By Bahar Yuksel

If gaining fertility back is the main goal, the surgical removal of endometriosis lesions is globally recognized as first-line therapy. Even though, pre- and postoperative hormone therapy leads to a significant decrease in the spread of the disease measured with the…

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The effects of nutrients on endometriosis-related symptoms

The effects of nutrients on endometriosis-related symptoms By Nasuhi Engin Aydin

A recent literature review from the Netherlands by researchers Emma Huijs and Annamiek Nap, published in "Reproductive Biomedicine Online" puts light on the effects of some nutrients for endometriosis-related symptomatology.  Endometriosis has heterogeneous pathogenesis involving genetic, immunological, environmental, and hormonal…

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Early maternal separation and endometriosis progression in adult mice

Early maternal separation and endometriosis progression in adult mice By Hale Goksever Celik

The quality of life in the women affected by endometriosis depends on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Although several studies have been performed to investigate the underlying pathophysiologic mechanism, it…

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Increased expression of epithelial cell adhesion molecule and its possible role in epithelial-mesenchymal transition in endometriosis.

Increased expression of epithelial cell adhesion molecule and its possible role in epithelial-mesenchymal transition in endometriosis. By Dr. Youngran Park

Endometriosis is an estrogen-dependent disease that functional endometrial tissue exists outside both the uterine cavity and myometrium. The pathogenesis of endometriosis remains unclear and controversial. According to the implantation theory, which is the most well-known, migration and invasion are two…

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Fallopian tubes and endometriosis

Fallopian tubes and endometriosis By Selma Oransay

There are multiple theories to explain the pathogenesis of endometriosis, among which the most popular one is Sampson's retrograde menstruation theory. The role of endometrial stem cells/progenitors are widely studied to support the origin of ectopic lesions in recent decades.…

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Hormone Control Related Genes in Women With Endometriosis

Hormone Control Related Genes in Women With Endometriosis By Ellen Tumimbang

Endometriosis is an estrogen-dependent disease.  The development of endometriosis is stimulated by the specific ability to receive the estrogen that is needed for growth and differentiation of endometrial cells and has numerous biological functions in eutopic and ectopic endometrium. Estrogen…

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Endometriosis Impacts Transgender Adolescents

Endometriosis Impacts Transgender Adolescents By Irem Onur

Shim J.Y. et al, from Boston, Massachusetts retrospectively searched the electronic medical records of transmasculine patients younger than 26 years old who were diagnosed with dysmenorrhea and treated at Boston Children’s Hospital, between January 1, 2000, and March 1, 2020.…

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Clinical characteristics linked to recurrence of ovarian endometrioma

Clinical characteristics linked to recurrence of ovarian endometrioma By Nadire Duru

Endometriosis affects 10-15% of women. Three types of endometriosis are peritoneal, ovarian, and deep infiltrating endometriosis. Ovarian endometriosis is the most common type of endometriosis with a high rate of recurrence. Laparoscopy is the gold standard treatment for endometriosis and…

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The impact of obesity on safety and feasibility of laparoscopic endometriosis surgery

The impact of obesity on safety and feasibility of laparoscopic endometriosis surgery By Hale Goksever Celik

The quality of life in the women affected by endometriosis depends on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. The most common locations of endometriosis are ovary, ovarian fossa, uterosacral ligament, and…

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Adolescent endometriosis

Adolescent endometriosis By Timur Seckin

A recent article, led by experts from Peking Medical Union College, describes the clinical characteristics and postoperative symptoms of adolescent endometriosis. The authors inform that their report, which is published in the "Journal of Pediatric and Adolescent Gynecology", can provide…

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Suggested remedies for endometriosis patients during coronavirus pandemic

Suggested remedies for endometriosis patients during coronavirus pandemic By Nasuhi Engin Aydin

The pandemic of COVID-19 continues to have important effects on endometriosis patients worldwide. Many health care facilities stopped providing surgical management and outpatient appointments are canceled or postponed. Dr. Leonardi from Australia and associates from several countries published their proposals…

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Hysterectomy as a choise of chronic pelvic pain relief in endometriotic women.

Hysterectomy as a choise of chronic pelvic pain relief in endometriotic women. By Selma Oransay

Sandstrom et al. from the Department of Obstetrics and Gynecology of Umea University, Sweden, found a significant and long-lasting reduction in pain symptoms after hysterectomy among women with confirmed endometriosis and recently published their results in "BJOG". The authors performed…

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Occult microscopic endometriosis in clinically negative peritoneum

Occult microscopic endometriosis in clinically negative peritoneum By Irem Onur

Occult microscopic endometriosis may be present in approximately 39% of patients with clinically negative appearing peritoneum undergoing laparoscopy for chronic pelvic pain. This finding is presented in a study published online this month in the International Journal of Gynecology &…

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Adolescent dysmenorrhea diagnosis and management

Adolescent dysmenorrhea diagnosis and management By Hale Goksever Celik

Endometriosis is usually diagnosed in reproductive-aged women. However, recent literature proved that clinical symptoms of endometriosis are also seen the adolescent girls and young women. Dysmenorrhea, the most common gynecologic complaint among this age group, can develop due to endometriosis.…

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Bone morphogenetic protein and endometriosis

Bone morphogenetic protein  and endometriosis By Nadire Duru

Endometriosis is a chronic disease characterized by the presence of endometrial glands and stroma outside the uterus, associated with several discomforts such as pelvic pain, menstrual disorders, and infertility. Although endometriosis is categorized as a benign lesion, the ectopic endometrial…

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Local inflammation and follicle development in women with ovarian endometriosis

Local inflammation and follicle development in women with ovarian endometriosis By Dr. Youngran Park

Endometriosis, a cause of subfertility, is found in almost 50% of infertile women. The elevated levels of cytokines in the follicular fluid of patients with endometriosis might account for the ovulatory dysfunction. Granulosa cells (GCs) play important roles in follicular…

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Anogenital distance and endometriosis

Anogenital distance and endometriosis By Timur Seckin

Endometriosis may be associated with exposure of the embryo to chemicals called ‘endocrine disruptors’. Exposure to endocrine disruptors can be estimated by measuring the anogenital distance (i.e. the distance between the clitoris and the anus), using a centimeter ruler with…

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International experts commentary for assisted fertility treatment facilities amidst COVID-19

International experts commentary for assisted fertility treatment facilities amidst COVID-19 By Nasuhi Engin Aydin

A multinational and multi-institutional commentary led by Dr. Alviggi from Italy and Dr.Esteves from Brazil has addressed important issues on assisted reproductive technology treatment amid COVID-19 lockdown suggesting remedies in the journal of "Reproductive Biology and Endocrinology" May 2020 issue.…

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The effect of endometriosis on the quality of life

The effect of endometriosis on the quality of life By Hale Goksever Celik

Endometriosis, the disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity, can be diagnosed in the reproductive-aged women with an incidence of 7-15%. However, endometriosis is observed in women with chronic pelvic pain syndrome…

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Endometriosis Diagnosis in White, Black, and Asian Women

Endometriosis Diagnosis in White, Black, and Asian Women By Özge Özkaya

In a commentary published in the "International Journal of Obstetrics and Gynaecology", Drs. Farland and Horne talk about a study by researchers in Canada and the Philippines, which found that black women are less likely, and Asian women are more likely to…

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Diagnosing Deep Endometriosis Using Transvaginal Elastosonography

Diagnosing Deep Endometriosis Using Transvaginal Elastosonography By Murat Osman

Deeply infiltrating endometriosis (DIE) is an advanced form of endometriosis that causes significant morbidity to a large number of women. Early detection of endometriosis is imperative for early treatment and improved outcomes for these patients. Currently, transvaginal ultrasound (TVUS) and magnetic…

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Menstrual Blood Proteins for Endometriosis Diagnosis

Menstrual Blood Proteins for Endometriosis Diagnosis By Ellen Tumimbang

Endometriosis is a gynecological disorder characterized by endometrial tissue outside the uterine cavity. The backflow of menstrual blood from the uterus through the fallopian tubes is thought to be the cause of endometrial tissue growing outside the uterine cavity when…

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A hope for postoperative symptomatic endometriosis therapy

A hope for postoperative symptomatic endometriosis therapy By Irem Onur

A new chapter in the treatment of symptomatic endometriosis patients may begin since new medical approaches including oral GnRH antagonists, selective progesterone receptor modulators, aromatase inhibitors, and peritoneal immune response modulators are being actively evaluated. To date, there was only…

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Opioids use in women with endometriosis, what does it tell us?

Opioids use in women with endometriosis, what does it tell us? By Yu Yu

Endometriosis is a debilitating disease that can cause many painful symptoms such as dysmenorrhea, dyspareunia, infertility, chronic pelvic pain, abdominal pain, and sacral or low back pain. More than half of women diagnosed with endometriosis suffer from chronic pelvic pain.…

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Diagnosis and treatment algorithm for endometriosis

Diagnosis and treatment algorithm for endometriosis By Selma Oransay

Endometriosis is a chronic and progressive disease that affects 25-30% of women between 25-35years, clinicians commonly experience during their gynecologic practice. However, the diagnosis is still late or sometimes incorrect, and this creates severe health problems and worse outcomes. A…

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Endometriosis by Race

Endometriosis by Race By Hale Goksever Celik

Endometriosis is usually diagnosed in reproductive-aged women with an incidence of approximately 10%. The most common presenting symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility in patients with endometriosis. Some risk factors have been identified for the development of…

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Health inequalities in USA

Health inequalities in USA By Timur Seckin

Dr. E. Albert Reece, the vice president for medical affairs at the University of Maryland, Baltimore, specialized in maternal and fetal medicine, wrote on health disparities in the American nation, in Obstetrics and Gynecology News, on the website www.mdedge.com, in June…

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Discrepancies between racial/ethnic groups and choice of hysterectomy procedures

Discrepancies between racial/ethnic groups and choice of hysterectomy procedures By Nasuhi Engin Aydin

Dr. Pollack and associates from Washington University, St.Louis, made multistate research regarding the patient profile in hysterectomies and published their results in the 2019 December issue of "The Journal of Minimally Invasive Gynecology". The most frequently performed nonobstetric surgery in…

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Is oocyte cryopreservation useful for fertility preservation in ovarian endometriosis?

Is oocyte cryopreservation useful for fertility preservation in ovarian endometriosis? By Irem Onur

Women with endometriosis tend to have lower fecundity compared to normal couples. Furthermore,  endometrioma itself may reduce the ovarian reserve by altering ovarian physiology in the surrounding healthy ovarian tissue. The treatment for endometrioma is surgical removal in most cases, however,…

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How Can Racial and Ethnic Disparities Be Reduced Among Women’s Health and Healthcare?

How Can Racial and Ethnic Disparities  Be Reduced Among Women’s Health and Healthcare? By Özge Özkaya

The American College of Obstetricians and Gynecologists published a set of recommendations to help reduce racial and ethnic disparities in women’s health and healthcare and encourage obstetricians, gynecologists, and other health care practitioners to engage in activities to help achieve…

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Endometriosis surgery and future pregnancy complications

Endometriosis surgery and future pregnancy complications By Selma Oransay

Endometriosis is one of the known diseases for infertility in the reproductive period of women. Several studies revealed that endometriosis itself maybe the reason for some unfavorable obstetric outcomes. Localization, the type of endometriotic lesions, and the stage of endometriosis…

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Case-control study to develop a questionnaire for early diagnosis of endometriosis

Case-control study to develop a questionnaire for early diagnosis of endometriosis By Nadire Duru

Endometriosis, which affects 5–10% of women of reproductive age, is a chronic gynecological disease characterized by the presence of endometrial glands and stroma outside the uterus, associated with several discomforts such as pelvic pain, menstrual disorders, and infertility. Ultrasound evaluation…

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The predictors for sexual dysfunction in infertile women with endometriosis

The predictors for sexual dysfunction in infertile women with endometriosis By Hale Goksever Celik

Endometriosis is a disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. Its incidence ranges up to 10% of reproductive-aged women. The most common symptoms in these women are chronic pelvic pain, dyspareunia, and…

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Immune System, Cytokines and Endometriosis

Immune System, Cytokines and Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent chronic disease. Diagnosing endometriosis is difficult because the signs and symptoms vary considerably. Therefore, the discovery of a reliable non-invasive diagnostic biomarker would represent a major advance for the clinical diagnosis of endometriosis.  It has been…

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Neglected needs of endometriosis and infertility patients during COVID-19 pandemic

Neglected needs of endometriosis and infertility patients during COVID-19 pandemic By Timur Seckin

With the global outbreak of the COVID-19, hospitals canceled surgeries and people are afraid of going to hospitals. However, chronic diseases still need to be managed. Rowe H. and Quinlivan J., researchers from Australia, pointed out the neglected needs of…

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Risk Factors Associated with Ureteral Endometriosis

Risk Factors Associated with Ureteral Endometriosis By Özge Özkaya

Patients with severe endometriosis, uterosacral ligament deep involvement with endometriosis lesions of  3 cm in diameter or more, and the presence of previous endometriosis surgery have a significantly higher risk of having ureteral endometriosis. This is according to a study…

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Resveratrol for infertility: A frenemy?

Resveratrol for infertility: A frenemy? By Selma Oransay

Ovarian aging is defined by an age-specific decline of the functional ovarian reserve. Female ovarian reserve declines progressively with increasing chronological age. Chronic damage by reactive oxygen species results in deterioration and aging through mitochondrial dysfunction, telomere shortening, cohesion dysfunction,…

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Fatigue from the viewpoint of patients with endometriosis

Fatigue from the viewpoint of patients with endometriosis By Irem Onur

Fatigue, feeling spoonie, is documented as a significant symptom of endometriosis in many studies. Researchers from three different institutions dealing with reproductive health conducted individual interviews with patients reporting moderate to severe endometriosis-related pain to better understand endometriosis-related fatigue and…

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Postmenopausal endometriosis: Is it a rare phenomenon?

Postmenopausal endometriosis: Is it a rare phenomenon? By Hale Goksever Celik

Endometriosis, the estrogen-dependent disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity, is generally diagnosed in the reproductive-aged women. However, recent literature proved that this disease can also be observed in the premenopausal and…

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NAT2 as potential biomarker for the diagnosis and treatment of endometriosis

NAT2 as potential biomarker for the diagnosis and treatment of endometriosis By Nadire Duru

Endometriosis affects 5–10% of women of reproductive age causing several discomforts, pelvic pain, menstrual disorders, ectopic bleeding, infertility, and sometimes even malignant transformation but its etiology remains unclear. Accumulating evidence point a key role for genetic factors and there is…

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miR-92a and progesterone resistance in endometriosis

miR-92a and progesterone resistance in endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. This incidence of this disease is 35% to 50% among those who suffer from chronic pelvic pain and infertility, which has a negative effect on the quality of life and on health. Recent genome-wide associations…

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Endometriosis and Insomnia

Endometriosis and Insomnia By Timur Seckin

There should be more awareness among clinicians for the relationship between insomnia and endometriosis, the study suggests. There needs to be a suspect of endometriosis whenever the clinician faces women of reproductive age with sleep or insomnia-related symptoms. This symptom is…

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Progressive nature of ovarian endometrioma

Progressive nature of ovarian endometrioma By Yu Yu

The effective management of endometriosis requires a proper understanding of how the condition progress as women age, especially for those women with early onset of endometriosis. Several studies have tried to characterize the evolution of endometriosis. Some of the key…

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Improved fusion imaging for the detection of Endometriosis

Improved fusion imaging for the detection of Endometriosis By Murat Osman

This paper studied a new fusion method for magnetic resonance (MR) and ultrasound (US) imaging for the appropriate diagnosis of endometriosis. The diagnosis of endometriosis in patients with a chronic pelvic disease is delayed, due to the disease, patient, and physician-led…

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Appendiceal endometriosis

Appendiceal endometriosis By Selma Oransay

Jeong et al. from the Departement of Surgery, Trinity School of Medicine, Saint Vincent, recently published their interesting appendectomy case in "Hong Kong Medical Journal". In their case, endometriosis inside the cavity of the appendix mimicked appendicitis, the patient submitted…

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Defective “ferroptosis”: a new pathogenetic explanation of endometriosis

Defective “ferroptosis”: a new pathogenetic explanation of endometriosis By Nasuhi Engin Aydin

Dr. Ng and associates from Tufts University School of Medicine, Boston, USA made a comprehensive review of the role of the iron element in the development of endometriotic lesions. Though iron element is essential for cell survival, and its deficiency is important…

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Are endometriosis patients at higher risk of bipolar disorder?

Are endometriosis patients at higher risk of bipolar disorder? By Irem Onur

Endometriosis patients are prone to develop certain psychiatric disorders, including depression and anxiety, as well as bipolar disorder, according to a nationwide population-based cohort study from Taiwan. Bipolar disorder formerly called manic-depression is a chronic mental disorder characterized by unusual changes…

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Maternal body mass index and neonatal outcomes in women with endometriosis

Maternal body mass index and neonatal outcomes in women with endometriosis By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal-like tissue outside the uterine cavity. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of…

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Interleukin-37b inhibits the growth of murine endometriosis-like lesions

Interleukin-37b inhibits the growth of murine endometriosis-like lesions By Nadire Duru

Endometriosis is a chronic gynecological disease that causes chronic pain and infertility in women. Despite continuous efforts and numerous research, there is, ultimately, still much to understand about the pathogenesis of endometriosis. Inflammatory factors including several interleukins have already been…

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Hysterolaparoscopy Plus Assisted Reproduction Improves Fertility in Women with Endometriosis

Hysterolaparoscopy Plus Assisted Reproduction Improves Fertility in Women with Endometriosis By Özge Özkaya

Hysteroscopy and laparoscopic surgery is an effective and reliable therapeutic procedure, confirmed a study published in the "Journal of Clinical Medicine". The approach is even more effective when combined with assisted reproductive techniques such as artificial insemination and in vitro…

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Steroid hormone receptors in endometriosis

Steroid hormone receptors in endometriosis By Yohan Suryo

Therapeutics that target the steroid hormones are the standard treatment for women with endometriosis because steroid hormones play an important role in endometrial physiology and pathogenesis of endometriosis. Examples of these therapeutics include anti-estrogens, estrogen receptor (ER) modulators, progestins, and…

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How should MRI images be obtained for optimal endometriosis detection?

How should MRI images be obtained for optimal endometriosis detection? By Murat Osman

It is well known that the diagnosis of endometriosis for some patients with the chronic pelvic disease is delayed, often for years, due to the disease, patient, and physician-led factors. An area of active study is how ordering physicians can…

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Transvaginal sonography for predicting the distance between rectosigmoid endometriosis and the anal verge

Transvaginal sonography for predicting the distance between rectosigmoid endometriosis and the anal verge By Timur Seckin

For optimal surgery, pre-surgical assessment of the distance between rectosigmoid deep endometriosis lesions and the anal verge (Lesion to Anal Verge Distance-LAVD) is recommended by many specialists. A group of researchers from Norway, Austria, and Australia studied the accuracy of…

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Oxidative stress leads to elevated cytokines, excessive structural damage and angiogenesis

Oxidative stress leads to elevated cytokines, excessive structural damage and angiogenesis By Yu Yu

Endometriosis is characterized by elevated intracellular reactive oxygen species, which is then believed to upregulate inflammatory cytokines. Reactive oxygen species also regulate the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which is closely linked with immune responses.…

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Surgical approach to rectovaginal endometriosis.

Surgical approach to rectovaginal endometriosis. By Selma Oransay

Recto-vaginal endometriosis incidence is estimated at 3.8%-37% among women with endometriosis and when it exists it's a part of deeply infiltrated endometriosis, thus advance stage endometriosis. Raimondo et al. from the Department of Obstetrics and Gynecology of the University of…

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tRNA-derived fragments in ovarian endometriosis?

tRNA-derived fragments in ovarian endometriosis? By Dr. Youngran Park

Endometriosis is an estrogen-dependent mysterious disorder characterized by the presence of endometrium outside the normal location of the uterus cavity. This disease affects approximately 10% of reproductive-aged women and becomes a major reason for infertility in reproductive-aged women and dysmenorrhea…

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Recurrence following surgery for subtypes of endometriosis

Recurrence following surgery for subtypes of endometriosis By Hale Goksever Celik

Endometriosis is a disease identified by the location of endometrial stromal and glandular cells outside the uterine cavity. It is considered as a gynecological disease of reproductive-aged women. Three subtypes of endometriosis are peritoneal endometriosis which defines the endometriotic lesions…

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The efficacy of combined hormonal contraception on pelvic pain in endometriosis patients

The efficacy of combined hormonal contraception on pelvic pain in endometriosis patients By Irem Onur

Chronic pelvic pain, which is experienced by more than 33% of endometriosis patients, constitutes a significant challenge for patients and physicians. A new study that appears in the journal Human Reproduction Open has explored the prevalence of endometriosis patients with a history…

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Antioxidants inhibit autophagy in ectopic endometrial cells

Antioxidants inhibit autophagy in ectopic endometrial cells By Nadire Duru

Factors involved in the development of ectopic endometrium are not well-known, but several reports demonstrate a potential role for the pathophysiological processes including autophagy. Studies show that autophagy plays a significant role in endometriosis but the key mechanisms underlying the…

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A Routine Pelvic Ultrasound Examination Should Include an Evaluation for Endometriosis

A Routine Pelvic Ultrasound Examination Should Include an Evaluation for Endometriosis By Özge Özkaya

Routine pelvic ultrasound examination should be extended beyond the uterus and ovaries into the posterior and anterior pelvic compartments, according to Australian doctors.  With such examinations, deep infiltrating endometriosis nodules can be searched, say the authors, allowing women to be…

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Fertility conservation in women with endometriosis

Fertility conservation in women with endometriosis By Selma Oransay

Endometriosis affects 10-15% of women in their reproductive period and almost half of them may need Assisted Reproductive techniques to conceive. Moreover, increased malignancy risk is threatening the women with severe endometriosis in addition to their decreased ovarian reserve. Due…

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Imaging of gastrointestinal endometriosis

Imaging of gastrointestinal endometriosis By Murat Osman

Endometriosis is a disease characterized by the ectopic implantation of endometrial tissue to surrounding pelvic and extra-pelvic structures. One frequent site of involvement is the gastrointestinal(GI) tract, which occurs especially among women with deep infiltrating endometriosis. Most cases of GI-involving…

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Fertility preservation protocols in women with endometriosis

Fertility preservation protocols in women with endometriosis By Hale Goksever Celik

Infertility is one of the major symptoms in women with endometriosis. Childbearing at a delayed age is preferred by the majority of women recently who consult for the demand for fertility preservation procedures. There are several techniques for fertility preservation…

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Urgent Need For Building Resilience

Urgent Need For Building Resilience By Timur Seckin

According to Naeem et al.’s article, “Coping with Covid”, Cognitive Behavioral Therapy (CBT) is the ideal intervention tool to increase resilience. Their study has recently been published in "Kyber Medical University Journal". The authors investigate the psychological impact of the Covid-19…

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Early Life Factors for Endometriosis

Early Life Factors for Endometriosis By Dr. Youngran Park

Endometriosis affects approximately 10% of reproductive-aged women. Despite the significant impact, the etiology of endometriosis is still unclear. A recent systematic review of 15 studies of adolescents found that overall 65% of girls undergoing laparoscopic investigation were diagnosed with endometriosis.…

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Long-term Pregnancy Results after Surgical Removal of Endometrioma

Long-term Pregnancy Results after Surgical Removal of Endometrioma By Irem Onur

Sun et al., from China, investigated the pregnancy outcomes and the related factors in patients with endometrioma and stage III-IV endometriosis along with a long-term follow-up postoperatively. Their study has recently been published in the journal named "Advances in Therapy".…

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The Relationship Between Dyspareunia and Infertility in Endometriosis

The Relationship Between Dyspareunia and Infertility in Endometriosis By Selma Oransay

Wahl et al. from the Center of Pelvic Pain and Endometriosis British Columbia Women's Hospital, Vancouver, Canada studied with endometriotic patients suffering from dyspareunia who were referred to their center and built a cross-sectional study to investigate the relations between…

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All aspects of endometriosis reviewed with focus on modern management

All aspects of endometriosis reviewed with focus on modern management By Nasuhi Engin Aydin

Dr. Chapron and associates from academic centers in France published in Nature Review Endocrinology, a comprehensive review on endometriosis. The article is inclusive of all aspects of endometriosis but especially focuses on the management of the disease with its contemporary status.  Having a…

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Abdominal wall endometriosis: Who is at risk and what causes it?

Abdominal wall endometriosis: Who is at risk and what causes it? By Murat Osman

Endometriosis is a condition that can cause anatomic, hormonal, and inflammatory disturbances that may ultimately result in decreased fertility or infertility. It is a disease process that is defined as ectopic endometrial-like tissue implanting itself to various pelvic and extra…

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Polymorphisms and endometriosis: a systematic review and meta-analyses.

Polymorphisms and endometriosis: a systematic review and meta-analyses. By Yohan Suryo

The symptoms of endometriosis are varied among women and include chronic pelvic pain, infertility, and fatigue. There are no reliable blood tests and medical imaging techniques such as MRI and ultrasound are not always satisfactory. The lack of endometriosis-specific symptoms…

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Does Getting Pregnant Really Help When You Have Endometriosis?

Does Getting Pregnant Really Help When You Have Endometriosis? By Özge Özkaya

Pregnancy has a favorable impact on the volume of deep infiltrating endometriosis lesions according to a study published in the scientific journal "PLoS One". This is the first study that demonstrates such a favorable impact of pregnancy on endometriosis lesion…

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Kisspeptin and its Receptor in the Pathogenesis of Endometriosis

Kisspeptin and its Receptor in the Pathogenesis of Endometriosis By Irem Onur

It is known that matrix metalloproteinases (MMP) may play a role in the pathogenesis of endometriosis. For example, the upregulation of MMP-2 and MMP-9 may enhance the degradation of extracellular matrix proteins, facilitating cell migration and invasion. Kisspeptin (KISS1, also…

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The predictive factors for early spontaneous miscarriage in IVF/ICSI cycles

The predictive factors for early spontaneous miscarriage in IVF/ICSI cycles By Hale Goksever Celik

The most common presenting complaints of endometriosis are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Affected women demand therapy for these symptoms of endometriosis, notably fertility problems. The clinical pregnancy rate has increased up to 60% in assisted reproductive…

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Regulation of Inflammation in Endometriosis

Regulation of Inflammation in Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent and multifaceted gynecological condition. Unfortunately, this disease frequently causes chronic and cyclic pelvic pain. Though there are several treatments are available, there is not an actual cure for this disease. Therefore, the development of new therapy…

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Leiomyomas have similar genetic background with endometriosis

Leiomyomas have similar genetic background with endometriosis By Nasuhi Engin Aydin

This multicenter research conducted in institutions located in the USA and UK published in Nature Communications, October 2019 issue.  Leiomyomata of the uterus are hormone-dependent tumors with an estimated prevalence of about  20-77%. İn several publications. Research in uterine leiomyoma…

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Cycle-related gastrointestinal complaints in reproductive age young women

Cycle-related gastrointestinal complaints in reproductive age young women By Timur Seckin

An analysis of 1-year data on 266 patients who presented to the Clinic and Polyclinic for Gynecology and Reproductive Medicine at Jena University Hospital to undergo surgery for endometriosis and its symptoms was performed by Nicolaous K. et al., a…

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Clinical Evaluation of Endometriosis-Associated Pain

Clinical Evaluation of Endometriosis-Associated Pain By Nadire Duru

Endometriosis has a noteworthy impact on the quality of life of the patients diagnosed with it since it is associated with unpleasant conditions such as endometriosis-associated pain. The diagnosis of endometriosis is not always straightforward because of the varying symptoms…

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The relationship of serum concentrations of neuropilin-1 (NRP-1) and endometriosis

The relationship of serum concentrations of neuropilin-1 (NRP-1) and endometriosis By Irem Onur

Although many serum biomarkers or biomarker panels for endometriosis are evaluated, none of them is exact enough to be used in daily laboratory practice. In a recent study, which has been published in Scandinavian Journal Of Clinical and Laboratory Investigation, Barberic…

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The genetic mutations in uterine adenomyosis

The genetic mutations in uterine adenomyosis By Hale Goksever Celik

Adenomyosis is defined as the localization of endometrial stromal and glandular cells in the myometrium. This disease is a reproductive-aged women disease, like endometriosis. Additionally, adenomyosis is frequently observed together with endometriosis and leiomyomas due to common histological features and…

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How well do providers understand endometriosis?

How well do providers understand endometriosis? By Demet Candaş Green

Endometriosis is a challenging disease no matter what side of the equation you are in, a patient or a provider who cares for patients with the disease. It impacts millions of women worldwide, making it one of the most prevalent…

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Phytotherapy as an alternative endometriosis treatment

Phytotherapy as an alternative endometriosis treatment By Dr. Youngran Park

Endometriosis is an estrogen-dependent gynecological disease that affects 5–10% of women in fertile age. Different therapeutic strategies are available to treat this disease, such as surgery, hormonal therapies, and nonsteroidal anti-inflammatory drugs.  Medical therapy usually consists of different hormonal drugs,…

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Adiposity, endometriosis type and severity

Adiposity, endometriosis type and severity By Selma Oransay

Dr. Jiyoung from the division of Public Health, Department of Family and Preventive Medicine of the University of Utah, planned a prospective cross-sectional study to assess whether there is an inverse relationship between the adiposity and endometriosis. The results of…

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The role of microbiota in the etiopathogenesis of endometriosis

The role of microbiota in the etiopathogenesis of endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. Although many advanced types of research about the etiology, differential diagnosis and treatment have been performed, it still remains an enigmatic disease. Dr. Bedaiwy, a scientist and physician…

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Integrated bioinformatic analysis for endometriosis diagnosis

Integrated bioinformatic analysis for endometriosis diagnosis By Nadire Duru

Endometriosis is considered as a non-malignant disease, but it is associated with several unfavorable conditions including non‑menstrual pelvic pain and infertility. Surgical resection and hormone suppression are common means of treatments; however, several side-effects and the recurrence are not preventable.…

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Preoperative serum CA 125 levels predict the severity of adhesions in endometriosis

Preoperative serum CA 125 levels predict the severity of adhesions in endometriosis By Irem Onur

Lee Y. et al., a group of researchers from Korea evaluated the correlation between preoperative serum markers and pelvic adhesions in endometriosis patients and explored the markers’ clinical value for outcome prediction. They have recently published their study in the…

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Which treatment option improves fertility the most?

Which treatment option improves fertility the most? By Murat Osman

Endometriosis is a condition that causes anatomic, hormonal, and inflammatory disturbances that may ultimately result in decreased fertility or infertility. It is estimated that 30-50% of women with endometriosis suffer from infertility. Thus, the role of surgical, medical, or expectant…

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Treatment choices for abdominal wall endometriosis

Treatment choices for abdominal wall endometriosis By Selma Oransay

Welch et.al, from the Department of  Radiology, Mayo Clinic, Rochester, worked with his gynecologist colleagues to underline the current treatment algorithm of abdominal wall endometriosis in Mayo Clinic. Their experience results recently published in the journal "Abdominal Radiology". Abdominal wall…

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The role of acidic ribosomal protein P1 in Endometriosis

The role of acidic ribosomal protein P1 in Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. The disease develops and composed of the ectopic endometrial-like tissue which establishes primarily in the pelvic cavity. Previous findings clearly show that estrogen-related factors are critical for endometriosis development and progression. However, we do have…

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Woman at reproductive age suffering from migraines should consider getting evaluated for endometriosis.

Woman at reproductive age suffering from migraines should consider getting evaluated for endometriosis. By Demet Candaş Green

What do migraine and endometriosis have in common? One can easily answer “pain”. Turns out there are other shared aspects when it comes to these two conditions: both have a high prevalence in women of childbearing age, both suffer from…

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Rare lesions in the pathologic examinations of endometriosis.

Rare lesions in the pathologic examinations of endometriosis. By Selma Oransay

Dr. Glenn McCluggage from the Department of Pathology, Belfast Health, and Social Care Trust, penned a review about selected uncommon variants of endometriosis or benign alterations that may cause difficulties of pathologic diagnosis and provided all related histopathological illustrations in…

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A review of endometriosis in adolescent girls and young women

A review of endometriosis in adolescent girls and young women By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease which is commonly diagnosed in reproductive-aged women. On the other hand, this disease can develop earlier in life due to different etiopathogenetic mechanisms. Especially adolescents who experienced neonatal uterine bleeding are under the risk for…

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Role of miR-141 in endometriosis

Role of miR-141 in endometriosis By Nadire Duru

MicroRNAs (miRNAs) are short (18–24 nucleotides) endogenous non-coding RNAs that regulate a broad range of signaling pathways. They bind to specific sequences resulting in mRNA degradation and protein inhibition. Deregulation of miRNAs is associated with the development of many disease…

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Impact of Genetic Variations in Endometriosis

Impact of Genetic Variations in Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. This disease affects approximately 7% to 10% of reproductive-aged women and causes negative impacts on society. The underlying causes are unclear; therefore, the understanding of this disease remains a major clinical challenge. Endometriosis has a…

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The prevalence and severity of endometriosis today

The prevalence and severity of endometriosis today By Irem Onur

Ghiasi M. et al., a group of researchers from the USA, presented a comprehensive review of the prevalence, incidence, and stage of endometriosis worldwide as reported over the past 30 years. Researchers performed a search in four databases, including PubMed,…

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Worrying signs of Endometriosis on Hysterosalpingography

Worrying signs of Endometriosis on Hysterosalpingography By Murat Osman

Hysterosalpingography (HSG) is an imaging modality that utilizes fluoroscopy in order to evaluate the uterine cavity, fallopian tubes, and adjacent peritoneal cavity by injecting contrast media through the cervical canal. It is an important tool in the work-up of patients who…

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Endometriosis Severity and Complication Risks Following Laparoscopic Surgery

Endometriosis Severity and Complication Risks Following Laparoscopic Surgery By Özge Özkaya

In a research article published in the journal Acta Obstetricia et Gynecologica Scandinavica, researchers at Brigham and Women's Hospital in Boston, Massachusetts suggested that the severity of endometriosis could not be a predictor of the risk of post-operative complications. In…

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