Does endometrioma size have an effect on IVF/ICSI outcomes?

Does endometrioma size have an effect on IVF/ICSI outcomes? By Hale Goksever Celik

Assisted reproductive technologies including IVF/ICSI can be suggested as the therapeutic option in women with endometriosis-associated infertility. In literature, there is a controversy regarding the influence of endometrioma size on IVF/ICSI outcomes. The group led by Drs Chapron and Santoulli…

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Endometriosis Care Is More Patient-Centered for age older than 35

Endometriosis Care Is More Patient-Centered for age older than 35 By Özge Özkaya

Women younger than age 35 receive endometriosis care in a less patient-centered manner compared to older women, found a new study published in the Journal of Obstetrics and Gynecology. This finding underscores the importance of improving endometriosis care, especially for…

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Deep lateral parametrial endometriosis nerve-sparing surgery 

Deep lateral parametrial endometriosis nerve-sparing surgery  By Selma Oransay

Dr. Kanno et al. from the Department of Obstetrics and Gynecology of Kurashiki medical center, Okayama, Japan recently published a deep lateral parametrial endometriosis case report in the journal named Fertility and Sterility. The aim is to demonstrate the technical and…

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TSH receptor antibodies show promising results in the diagnostic workup of endometriosis

TSH receptor antibodies show promising results in the diagnostic workup of endometriosis By Nasuhi Engin Aydin

Dr. Svensson with collaborators from the Swedish Lund University has published their results on the possible role of TSH receptor antibodies as biomarkers in endometriosis diagnosis in a recent issue of “European Journal of Obstetrics & Gynecology and Reproductive Biology”.…

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How beneficial is colorectal surgery for patients with deep endometriosis?

How beneficial is colorectal surgery for patients with deep endometriosis? By Eylül GÜN

In cases of deep endometriosis, which causes more severe pain and gastrointestinal symptoms, the patient's quality of life and fertility outcomes are negatively affected. Surgical intervention is thought to be the optimal treatment method in colorectal deep endometriosis cases, however,…

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Postoperative serum markers to predict serum AMH recovery following endometriosis surgery

Postoperative serum markers to predict  serum AMH recovery following endometriosis surgery By Hale Goksever Celik

Women with endometriosis seek treatment including ovarian cystectomy, because of symptoms that reduce their quality of life. Ovarian cystectomy using laparoscopic or robotic devices is the preferred therapy. However, it has been shown in the literature that ovarian reserve is…

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Web-based resource to improve menstrual health awareness

Web-based resource to improve menstrual health awareness By Selma Oransay

Many women consider "menstrual pain" a normal part of being female, and do not seek medical help but rather use self-management methods such as heat, rest, and analgesics. They are often unsure which self-management strategies are effective or what the…

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Exposure to toxic metals and the risk of endometriosis

Exposure to toxic metals and the risk of endometriosis By Selma Oransay

Mercury, lead, and cadmium are the best-studied heavy metals for several adverse effects on the human reproductive system. Mercury can induce DNA damage, oxidative stress, and mitochondrial dysfunction, and lead exposure is associated with menstrual disorders, preterm birth, and miscarriage.…

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Time to change out taboos about the radiologic evaluation of scar endometriosis

Time to change out taboos about the radiologic evaluation of scar endometriosis By Bahar Yuksel

Scar endometriosis is one of the rare forms of endometriosis. According to traditional belief, it has always been evaluated radiologically on menstruation days. In the study conducted by Balaban et al, the authors compared the differences in lesions according to…

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The management of diaphragmatic endometriosis

The management of diaphragmatic endometriosis By Selma Oransay

Thoracic endometriosis is a rare disease, and it is likely to have been underdiagnosed and underreported. Optimal diagnostic testing and management options are yet to be determined. Imaging for thoracic endometriosis is still in its infancy, and MRI only helps to…

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Understanding what we see: endometriosis laparoscopic appearance and microscopic verification

Understanding what we see: endometriosis laparoscopic appearance and microscopic verification By Nasuhi Engin Aydin

Chia-Sui Weng and colleagues from the Mayo Clinic, USA have published their results on laparoscopic appearances and microscopy of endometriotic lesions in “The Journal of Minimally Invasive Gynecology”. Even though the diagnosis of endometriosis has evolved greatly with advanced imaging…

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Rhein usage in endometriosis: A potential new therapeutic agent

Rhein usage in endometriosis: A potential new therapeutic agent By Eylül GÜN

The invasive nature of endometriosis has prompted scientists to find preventative and curative methods.  The progression and proliferation of endometriotic lesions are being studied extensively. As one of the agents used in Chinese herbal medicine for inflammatory disorders, rhein is…

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Endometriosis and the possible mechanisms of pain.

 Endometriosis and the possible mechanisms of pain. By Selma Oransay

The most common clinical symptoms of endometriosis are chronic pelvic pain and infertility. It is often not enough to treat pain symptoms with hormonal therapy or a surgical approach. Moreover, the stage of endometriosis has weakly associated with the amount,…

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Organizing structural protein Ezrin and its active form in endometriosis biopsies

Organizing structural protein Ezrin and its active form in endometriosis biopsies By Nasuhi Engin Aydin

Dr. Alessandra Peloggia and colleagues from Brazil have published their results on immunostaining of Ezrin protein and its phosphorylated active form in endometrial tissues in a recent issue of “Clinics” Possible factors on endometrial cell implantation and proliferation in the…

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Endometriosis and the cumulative live birth rate in IVF cycles.

Endometriosis and the cumulative live birth rate in IVF cycles.  By Hale Goksever Celik

Infertility is one of the symptoms encountered in up to 40-50% of women with endometriosis. There are several pathophysiological theories suggesting the development of endometriosis-associated infertility. Assisted reproductive technology (ART) using in vitro fertilization and embryo transfer (IVF-ET) has been…

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Taller Girls More Likely to Have Recurring Endometriosis

Taller Girls More Likely to Have Recurring Endometriosis By Özge Özkaya

Adolescents who are taller and have three or more lesions are at a higher risk of endometriosis recurrence following surgery, according to a new study by Chinese researchers published in the Journal of Obstetrics and Gynaecology. They should, therefore, be…

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The dilemma of autophagy and its role in endometriosis

The dilemma of autophagy and its role in endometriosis By Eylül GÜN

Autophagy is a mechanism for cell survival under metabolic stress that involves the degradation and recycling of intracellular components. Multiple genes actively control this process. Among these, the initiation stage of autophagosome formation is regulated by the gene Beclin-1 and…

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Endometriosis and Body Image

Endometriosis and Body Image By Özge Özkaya

Endometriosis has a negative effect on health-related quality of life and body familiarity according to a new study published in the Journal of Psychosomatic Research. Based on this finding, the authors of the study recommend that body familiarity should be…

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A prediction model to identify endometriosis during routine ultrasound .

A prediction model to identify endometriosis during routine ultrasound . By Selma Oransay

. Ureterolysis is an advanced surgical technique that involves dissection of the ureter from pelvic brim to the ureteric tunnel to avoid injury or freeing the ureter from endometriotic lesions. This manipulation usually requieres advanced surgical training and skill. In…

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T-cell-targeted immunotherapy and immune checkpoint inhibitors for the treatment of endometriosis

T-cell-targeted immunotherapy and immune checkpoint inhibitors for the treatment of endometriosis By Nasuhi Engin Aydin

Dr. Monika Abraimuk and colleagues from Poland published their review on "the importance of immunity in endometriosis" in a recent issue of the medical journal “Cellular Signaling”. A great challenge in contemporary medical issues is endometriosis which still lacks a…

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How do the couples feel when dealing with endometriosis?

How do the couples feel when dealing with endometriosis? By Eylül GÜN

The effects of endometriosis on the patients' psychosocial well-being are well known. However, not many studies have investigated how it impacts the well-being of partners and couples. A few studies focused on the male perspective of the disease, whereas some…

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Parametrial endometriosis and postoperative voiding dysfunction.

Parametrial endometriosis and postoperative voiding dysfunction. By Selma Oransay

Parametrium constitutes a complex connective tissue containing blood vessels, the ureter, and the inferior hypogastric plexus, that extends from the lateral surface of the cervix and vagina to the lateral pelvic wall. Parametrial endometriosis may involve the vessels, nerves, and…

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The association between severe endometriosis and venous thromboembolism

The association between severe endometriosis and venous thromboembolism By Hale Goksever Celik

For clarifying the issue of whether endometriosis patients are at risk for venous thromboembolism due to both their local immune and inflammatory responses and hormonal treatments, Wiegers et al,  from the Netherlands, published an explorative cohort study entitled “Risk of…

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Researchers Develop New Mouse Model of Endometriosis

Researchers Develop New Mouse Model of Endometriosis By Özge Özkaya

Researchers from China developed a new mouse model to study endometriosis that could help researchers better understand the molecular mechanisms that lead to the development of endometriosis and develop potential new treatments for the disease.  Even though many animal models…

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Do endometriosis patients have increased risk of stroke?

Do endometriosis patients have increased risk of stroke? By Nasuhi Engin Aydin

Dr. Leslie V. Farland and colleagues from the University of Arizona, published their prospective research on the risk of stroke in women with laparoscopically confirmed endometriosis in a recent issue of a scientific journal named  “Stroke”. Endometriosis is a chronic…

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Pelvic pain characteristics in young girls with endometriosis.

 Pelvic pain characteristics in young girls with endometriosis. By Selma Oransay

The occurrence of severe and frequent pelvic pain in young women is a piece of evidence that endometriosis begins and develops at an early age. Two-thirds of women with endometriosis who were diagnosed in their adulthood reported the onset of…

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Endometriosis Prediction by "Machine Learning"

Endometriosis Prediction by By Selma Oransay

To develop a predictive model for endometriosis and to re-assess the contribution of known risk factors, Blass et al. from the Hebrew University of Jerusalem, Jerusalem, Israel used the data of the UK biobank by machine learning-based models. They compared and…

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Placenta Previa More Common Among Pregnant Women With Endometriosis

Placenta Previa More Common Among Pregnant Women With Endometriosis By Özge Özkaya

Endometriosis is associated with a higher risk of placenta previa, according to a new study published in the scientific journal Reproductive Sciences. This is the case whether the women became pregnant following in vitro fertilization (IVF). Moreover, for women with endometriosis…

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Vitamin C as a possible therapeutic agent in endometriosis

Vitamin C as a possible therapeutic agent in endometriosis By Eylül GÜN

A rather toxic environment is generated with the production of reactive oxygen species by the immune cells in endometriosis. The anti-oxidant metabolism is also altered which results in a state of oxidative stress. As a potent antioxidant, Vitamin C has…

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A call for mast cells from endometriotic lesions

A call for mast cells from endometriotic lesions By Bahar Yuksel

Endometriosis is a well-known hormonal-dependent inflammatory disease. But what type of inflammatory cells is responsible, and when does estrogen take part, are questions that have not been answered yet. In the study conducted by Alison McCallion et al, the role…

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Fibrosis is not only a histological finding in endometriosis

Fibrosis is not only a histological finding in endometriosis By Eylül GÜN

Endometriosis remains to be an active subject of research with its complex pathophysiology and the indistinct mechanisms that cause the proliferation and progression of the lesions. Besides the already known characteristics of the disease, there is strong evidence to support…

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Study Identifies Factors Associated With Risk of UrinaryTract Endometriosis Recurrence

Study Identifies Factors Associated With Risk of UrinaryTract Endometriosis Recurrence By Özge Özkaya

Being younger than age 25 and having an autoimmune disease are significant predictors of the recurrence of urinary tract endometriosis after surgery according to a new study published in the Journal of Minimally Invasive Gynecology. Adjuvant hormonal therapy, on the…

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To Remove the Ovary(ies) or Not During Hysterectomy for Endometriosis

To Remove the Ovary(ies) or Not During Hysterectomy for Endometriosis By Selma Oransay

Some surgeons prefer empiric bilateral salpingo-oophorectomy during the hysterectomy of women with endometriosis based on the knowledge that endometriosis is stimulated by endogenous estrogens, as leaving the ovaries in situ may increase the possibility of endometriosis recurrence and pelvic pain.…

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Coexistence of endometriosis and cardiovascular diseases

Coexistence of endometriosis and cardiovascular diseases By Hale Goksever Celik

The most common presenting complaints are mainly pelvic pain and infertility, most of which relate to the menstrual period. Affected women demand therapy for these symptoms of endometriosis, notably pelvic pain. Several theories have been proposed to explain the development…

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An important matter to revise: Immune system changes in endometriosis

An important matter to revise: Immune system changes in endometriosis By Eylül GÜN

Endometriosis is a multifactorial disease with unclear and obscure pathogenetic mechanisms. In their review, Chopyak et al. revised the immunopathogenic pathways that are proven and/or thought to be responsible for disease development and progression. The article was published in the…

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Endometriotic cyst fluid and the postoperative recurrence of endometriosis

Endometriotic cyst fluid and the postoperative recurrence of endometriosis By Nasuhi Engin Aydin

Dr. Xinxin Xu and colleagues from the Department of Obstetrics and Gynecology, School of Medicine, Zhejiang University, China, published their research on the viability of endometrial cells in ovarian cyst fluids in a recent issue of  “Journal of Ovarian Research”.…

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Transvaginal Ultrasound Could Be Sufficient to Properly Diagnose Deep Endometriosis and Ovarians Endometriomas

Transvaginal Ultrasound Could Be Sufficient to Properly Diagnose Deep Endometriosis and Ovarians Endometriomas By Özge Özkaya

Following the International Deep Endometriosis Analysis consensus can improve the accuracy of transvaginal ultrasound to diagnose ovarian endometriomas and deep infiltrating endometriosis, according to a new study published in the scientific journalUltrasound in Obstetrics & Gynecology. “ (…) at this…

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Endometriosis and environmental factors

Endometriosis and environmental factors By Selma Oransay

The estrogen-dependent nature of endometriosis has generally led to search endocrine-based causes. Especially, polychlorinated biphenyls, dioxins, and Dietilstilbesterol are the most studied chemicals in the literature. Interesting data that needs confirmation in the future also suggest a link with night…

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Fallopian tube occlusion in infertile women with endometriosis

Fallopian tube occlusion in infertile women with endometriosis By Hale Goksever Celik

Women with endometriosis suffer from fertility problems with an incidence of 40-50%. Among the pathophysiologic mechanisms resulting in impaired fertility in women with endometriosis, distorted pelvic anatomy due to adhesions,  impaired follicular quality-quantity, dysfunction of tubal peristalsis, and implantation problems…

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The Oocyte Quality in Ovarian Endometriosis

The Oocyte Quality in Ovarian Endometriosis By Selma Oransay

Endometrioma is the ovarian involvement of endometriosis affecting up to 44% of women diagnosed with the disease. Owing to the anatomical locus, ovarian endometriosis may impair folliculogenesis and oocyte competence, differing from other forms of endometriosis.  When investigating the relationship between…

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The effects of resveratrol on endometriotic cells

The effects of resveratrol on endometriotic cells By Eylül GÜN

The current treatment methods for endometriosis still carry recurrence risks and side effects from medications. Herbal medicine has been investigated and used as an additional alternative method. Derived from several plants and found in some dietary sources, resveratrol is a…

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The best method for the diagnosis of endometriosis: SEE and BELIEVE

The best method for the diagnosis of endometriosis: SEE and BELIEVE By Eylül GÜN

Deciding on the best diagnostic procedure for endometriosis patients has been a recent subject of debate. While some clinicians believe non-invasive methods such as imaging and symptom-based treatment should be the choice in the diagnosis, some believe the best method…

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Validity of Magnetic Resonance Imaging for Deep Pelvic Endometriosis.

Validity of Magnetic Resonance Imaging for Deep Pelvic Endometriosis. By Selma Oransay

Video laparoscopy has become a valuable tool for diagnosing and managing endometriosis in recent years. In cases associated with deep infiltrating endometriosis, the need for a non-invasive diagnostic method before laparoscopic evaluation paves the way for using MRI.  The use…

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Gluten Intake May Not Have an Effect on Endometriosis

Gluten Intake May Not Have an Effect on Endometriosis By Özge Özkaya

Carbohydrate quality and certain types of fiber such as total vegetable and cruciferous vegetable fiber seem to be associated with endometriosis in women before menopause, found a new study published in the Journal of Nutrition. According to the study, it…

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Start exercising for pain relief

Start exercising for pain relief By Bahar Yuksel

Physical exercises have always been suggested for chronic pain-related diseases as well as endometriosis. However, the effect of exercise and the frequency that is effective on pain relief is unknown. In the study conducted by Ipek Ensari et al, a…

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Combined "Platelet-to-lymphocyte ratio and CA125" may be promising predictor for adhesions

Combined By Nasuhi Engin Aydin

Drs. Guo & Zhang from the Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China published their manuscript on the importance of combined "platelet-to-lymphocyte ratio and CA125 level" as a biomarker of endometriosis in a recent…

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Sex Education For The Sexual Quality Of Life

Sex Education For The Sexual Quality Of Life By Hale Goksever Celik

The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Decreased quality of life due to pelvic pain, dyspareunia, and psychological conditions such as anxiety and depression can lead to sexual dysfunction in women with endometriosis.…

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Estradiol metabolism, endometriosis and migraine

Estradiol metabolism, endometriosis and migraine By Bahar Yuksel

Endometriosis and migraine are the leading pain diseases of women of reproductive ages. As both are known to be induced by hormonal changes, in the review conducted by Joy-Fleur van der Vaart et al, the authors aimed to find out the…

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Time has come to learn more about endometriosis and take action!

Time has come to learn more about endometriosis and take action! By Eylül GÜN

It has been a long time since endometriosis was defined. Extensive population studies have shown that around 10% of women suffer from this condition. Depending on its severity, it alters the various functions of the body and causes the patients…

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Does the timing of endometriosis diagnosis affect optimal infertility treatment?

Does the timing of endometriosis diagnosis affect optimal infertility treatment? By Selma Oransay

Based on a retrospective population-linked data study in "Human Reproduction", the ESHRE journal club featured a detailed discussion with 50 participants, patients’ representatives, and experts (Paola Vigano´, Mathew Leonardi, Thomas D’Hooghe, Louise Hull), together with the authors of the original article, mainly…

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New Endometriosis Self-Assessment Tool Could Help Women Seek Timely Medical Attention

New Endometriosis Self-Assessment Tool Could Help Women Seek Timely Medical Attention By Özge Özkaya

Researchers from Korea developed a self-assessment tool that may allow women to determine their risk of endometriosis. They described the tool in an article they published in the scientific journal Obstetrics & Gynecology Science. “The devised tool appears valid and…

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Genomic evidence: The recognition of endometriosis as an inflammatory systemic disease

Genomic evidence: The recognition of endometriosis as an inflammatory systemic disease By Nasuhi Engin Aydin

Dr. Bao and associates from Shangai-China published a new article on the genomic features of endometriosis that could yield information on its inflammatory basis and possible therapeutic potential in a recent issue of “Frontiers ın Immunology”. Endometriosis is a systemic process…

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Evaluation of retrocervical and parametrial deep endometriosis by detailed ultrasonography

 Evaluation of retrocervical and parametrial deep endometriosis by detailed ultrasonography By Selma Oransay

The accuracy of ultrasonographic diagnosis of deep endometriosis in the retrocervical and parametrial areas may be poor due to the variable morphology of endometriotic lesions, the complex structure of the posterior parametrial compartment, and the difference in examiners' experience level.…

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Research Identifies Blood Proteins Associated With Endometriosis in Adolescents

Research Identifies Blood Proteins Associated With Endometriosis in Adolescents By Özge Özkaya

Proteins related to angiogenesis or the formation of new blood vessels and cellular migration are enriched and more active in the blood of adolescents with endometriosis compared to healthy controls. These are the findings of a new study published in…

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Chasing gold to find endometriosis.

Chasing gold to find endometriosis. By Bahar Yuksel

Endometriosis is a disease that doesn’t have a proper preoperative diagnostic test. Thus, animal models to study endometriosis are vital to show the effects of drugs and the effects of the disease on the body. In the study conducted by…

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Endometriosis-associated infertility: How to manage?

Endometriosis-associated infertility: How to manage? By Hale Goksever Celik

Although the underlying reason for endometriosis has not been fully established, there is an association between endometriosis and infertility. Endometriosis is thought to be involved in 40-50 percent of infertility cases. However, natural conception can still occur even in women…

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Is it possible to reduce pain by diet in endometriosis?

Is it possible to reduce pain by diet in endometriosis? By Eylül GÜN

Endometriosis-related pain is one of the most common symptoms of endometriosis that significantly affects the patient's quality of life. The peripheral and central sensitization, caused by chronic inflammation activation, may result in referred pain. The pain perception was shown to…

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Would it be possible to diagnose endometriosis from a vaginal swab?

Would it be possible to diagnose endometriosis from a vaginal swab? By Nasuhi Engin Aydin

Ectopic endometrial tissues with new vessel formations in an inflammatory background have a component of mast cell-derived exosomal tRF-Leu-AAG-001 promoting inflammation and angiogenesis. This information is according to the paper published in a recent issue of the journal “BMC Women’s Health”,…

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A new potential therapeutic target in endometriosis: Galectin-3

A new potential therapeutic target in endometriosis: Galectin-3 By Eylül GÜN

The endometrial cells migrate and attach to the peritoneal surface according to the most widely accepted retrograde menstruation theory in endometriosis development. Given that only 10% of women have endometriosis, it is thought that some additional factors contribute to the…

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The role of oxidative stress on endometriosis symptomatology

The role of oxidative stress on endometriosis symptomatology By Bahar Yuksel

Endometriosis is not only a hormonal disease, but it is also an inflammatory illness provoked by hormones. In the review conducted by Hossein Ansariniya et al., from Iran, the relation between oxidative stress, free radicals, free iron, and the development of…

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How do regional differences affect the incidence rates of endometriosis?

How do regional differences affect the incidence rates of endometriosis? By Eylül GÜN

Despite all the ongoing work for endometriosis awareness, it continues to be an underdiagnosed disease. Several different factors are responsible for this. The variations of its symptomatology play a big part as well as the lack of understanding of the…

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Fertility assessment and surgical approach in endometriotic patients.

Fertility assessment and surgical approach in endometriotic patients. By Selma Oransay

The prevalence of endometriosis is around 50-70% in women with pelvic pain, and it has been reported as 50% in patients with infertility. Severe adhesive disease associated with advanced endometriosis is a cause of fertility impairment. The relationship between endometriosis…

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The effect of chronic endometritis on pregnancy outcomes in infertile women having minimal/mild endometriosis

The effect of chronic endometritis on pregnancy outcomes in infertile women having minimal/mild endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease that is frequently diagnosed in reproductive-aged women. Infertility can be associated with endometriosis in these women depending on several pathophysiologic mechanisms such as anatomic distortion, and implantation failure. Thus pregnancy rate is so important, especially…

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Understanding the expression of endometriosis-related pain: A barrier to overcome

Understanding the expression of endometriosis-related pain: A barrier to overcome By Eylül GÜN

It is difficult to describe the feeling of pain, one of the most important symptoms of endometriosis because it is subjective. Endometriosis-related pain is proven to be underestimated by some clinicians resulting in the patient getting a late diagnosis. It…

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Postoperative outcomes of deep intestinal endometriosis surgery.

 Postoperative outcomes of deep intestinal endometriosis surgery. By Selma Oransay

Invasion of endometriotic lesions to the bowels' mucosal and/or muscular levels is called intestinal deep endometriosis. These lesions are most frequently found in the rectosigmoid colon, followed by the rectum, ileum,  appendix, and caecum. The optimal surgical approach to intestinal deep…

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Soluble CD90 : a potential serum biomarker in endometriosis

Soluble CD90 : a potential serum biomarker in endometriosis By Nasuhi Engin Aydin

Dr. Bochev and colleagues from several medical centers in Bulgaria published their research on the role of a possible serum biomarker in diagnosing endometriosis in a recent issue of the journal named “Disease Markers”. The definitive diagnosis of endometriosis, an…

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Immune cells in peritoneal endometriosis

Immune cells in peritoneal endometriosis By Nasuhi Engin Aydin

Dr. Burcu Ersoy and associates from The University of Sydney, Australia, published their interesting study on surgically removed peritoneal endometriosis tissues in the journal named "F&S Science". It is still a dilemma how ectopic endometrial tissues attach to the peritoneum, persist…

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Ankylosing Spondylitis and Endometriosis

Ankylosing Spondylitis and Endometriosis By Hale Goksever Celik

There are several theories contributing the development of endometriosis: one of the proposed pathophysiological mechanisms is the abnormality in immune and inflammatory system. Several immunologic diseases coexist with endometriosis depending on the common immunologic characteristics such as Tumor necrosis Factor…

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The accuracy of transvaginal ultrasound and magnetic resonance imaging for deep urinary tract endometrisis.

The accuracy of transvaginal ultrasound and magnetic resonance imaging for deep urinary tract endometrisis. By Selma Oransay

The prevalence of urinary tract endometriosis is 19-53% in patients within deep infiltrating endometriosis cases. The bladder and ureteral are the most common sites of the involvement. While preparing a radical surgery for a patient with deep endometriosis, the diagnosis…

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A search for a marker to show the malignancy risk of endometriomas

A search for a marker to show the malignancy risk of endometriomas By Bahar Yuksel

The premalignant features and precursors that show the malignant potential in endometriomas are not well-known. In the systematic review conducted by Ludovica Bartiromo et al, the markers for malignant transformation have been analyzed and recently published in a recent issue of…

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Endometriosis in transmasculine people

Endometriosis in transmasculine people By Eylül GÜN

“Transmasculine” refers to people who were assigned female at birth but later identify themselves with masculinity. If they choose to transition to the male gender, they are then prescribed long-term testosterone and some may want to undergo a hysterectomy as…

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Chronic pelvic pain and endometriosis

Chronic pelvic pain and endometriosis By Selma Oransay

Patients may have an average of 7 clinical visits before being diagnosed with endometriosis. Understanding chronic pain conditions including endometriosis-associated pain, and developing chronic pelvic pain benefits the management of the patients. The role of central sensitization, comorbid conditions, and…

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Who Is Diagnosing my Endo?

Who Is Diagnosing my Endo? By Özge Özkaya

It is possible to acquire the skills necessary to diagnose endometriosis lesions as well as adenomyosis using three-dimensional rectosonography after a short learning period in an expert radiology center. This is according to a new study by French researchers published…

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Is it possible to predict recurrence after ovarian endometriosis surgery?

Is it possible to predict recurrence after ovarian endometriosis surgery? By Eylül GÜN

The current treatment methods for endometriosis both have their flaws: the medical treatment is sometimes ineffective and the surgical treatment comes with a high rate of recurrence. Even though new surgical modalities have been developed, laparoscopic cyst removal continues to…

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The association between inflammatory cytokines and fertility in women with endometriosis

The association between inflammatory cytokines and fertility in women with endometriosis By Hale Goksever Celik

Women with endometriosis suffer not only from a broad spectrum of symptoms including pain including dysmenorrhea, dyspareunia, and chronic pelvic pain but also fertility problems. Endometriosis-associated infertility develops depending on a combination of several mechanisms such as distorted pelvic anatomy,…

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The clearance system is defective for women who develop endometriosis

The clearance system is defective for women who develop endometriosis By Bahar Yuksel

Endometriosis is both a hormonal and an immune disease thus overcoming the immune response by improving the underlying mechanism would help fight the disease. In the study conducted by Dr.Guidice group at the University of California San Francisco, San Francisco, CA,…

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Surgery Improves the Sex Life and Sleep of Women With Endometriosis

Surgery Improves the Sex Life and Sleep of Women With Endometriosis By Özge Özkaya

Endometriosis surgery improves patients’ quality of life, sexual function, and sleep confirms a new study by Turkish researchers published in the scientific journal Archives of Gynecology and Obstetrics. According to the first author Dr. Belfin Nur Arici Halici of the…

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Does inhibiting the formation of the new blood vessels aid in endometriosis treatment?

Does inhibiting the formation of the new blood vessels aid in endometriosis treatment? By Eylül GÜN

Current treatment modalities for endometriosis include a hormonal alteration which has many side effects and surgical removal which has a high postoperative recurrence rate. Alternative non-hormonal treatment methods have been investigated and anti-angiogenic therapy is one of them. Dr.s Chung…

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Is there a component of "microflora imbalance" in endometriosis?

Is there a component of By Nasuhi Engin Aydin

Dr. Oishi and colleagues from Ryukyus and Mie Universities, Japan, published a prospective cohort study on the microbiota of the female genital tract in the journal "Reproductive Medicine and Biology". Recent studies have found a small number of bacteria in…

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Early menarche increases the risk of endometriosis.

Early menarche increases the risk of endometriosis. By Selma Oransay

Early menarche is the first menstrual bleeding occurring before 12 years of age. The timing of normal puberty in girls varies between nations due to genetic, socioeconomic, and environmental factors. Notably, the age of menarche decreased significantly in teenagers born…

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How does endometriosis affect the life course of the patients?

How does endometriosis affect the life course of the patients? By Eylül GÜN

Endometriosis, as a chronic disease has impairing effects on women’s lives. Patients carry psychological, social, and work-related burdens along with debilitating physical symptoms. Studies have been performed on these issues at a particular time in patients’ lives, however, only a…

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The relation between body mass index and endometriosis

 The relation between body mass index and endometriosis By Selma Oransay

The studies have emphasized a link between low BMI values and endometriosis, however, this conclusion may be questionable when the estrogen dependence of the disease is concerned. Excess adipose tissue may produce higher circulating estrogen that may result in an…

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Adenomyosis Increases Risk of Surgical Complications

Adenomyosis Increases Risk of Surgical Complications By Özge Özkaya

Adenomyosis increases the risk of deep endometriosis surgery complications, according to a new study published in the journal Scientific Reports. Patients with deep endometriosis and adenomyosis should therefore be informed about this risk before undergoing surgery. Adenomyosis occurs together with…

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The consequence of COVID-19 pandemic on endometriosis patients

The consequence of COVID-19 pandemic on endometriosis patients By Selma Oransay

The relevant policies and restrictions concerning Covid-19 have prevented patients from accessing medical care. Similarly, standard care for endometriosis patients has also been negatively impacted by postponed or canceled appointments and suspended surgeries across the countries. Women trying to cope…

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Preferential expression of some membrane type matrix metalloproteinase proteins

Preferential expression of some membrane type matrix metalloproteinase proteins By Nasuhi Engin Aydin

Dr. Maoga and associates from academic institutions located in Germany and Kenya have published their findings on the immunohistochemical expression of MT-MMP proteins, namely MT2-MMP (MMP15) and MT3-MMP (MMP16) in the eutopic endometrium of healthy and endometriotic patients; and also…

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The evaluation of sexual dysfunction in infertile women

The evaluation of sexual dysfunction in infertile women By Eylül GÜN

Infertility constitutes a serious health problem in women and men worldwide. The most common causes of women’s infertility are reported to be endometriosis and polycystic ovarian syndrome. The prevalence of infertility in women with endometriosis is as high as 50%.…

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Comparison of imaging techniques for estimating the depth of bowel wall infiltration by endometriosis.

Comparison of imaging techniques for estimating the depth of bowel wall infiltration by endometriosis. By Selma Oransay

The surgical removal of deep endometriosis is the cornerstone of the management. However, the decision for the varying surgical approach types ranging from conservative management (shaving) to segmental or discoid resection depends on the depth of infiltration within the bowel wall, which…

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Self-Management Strategies for Endometriosis

 Self-Management Strategies for Endometriosis By Özge Özkaya

Many self-management strategies for endometriosis are not more effective at reducing the symptoms of the disease compared to placebo or hormonal therapies, according to a new study published in the journal Reproductive Sciences.  The authors, therefore concluded that “no recommendations…

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Social media and endometriosis management

Social media and endometriosis management By Selma Oransay

Endometriosis has a negative impact on social life, work, daily activities, personal relationship, and overall quality of life. A study from Australia recently published in the Australian New Zeland Journal of Obstetrics and Gynaecology reports that social media helps these…

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Atherosclerosis is augmented in laboratory mice by experimental endometriosis

Atherosclerosis is augmented in laboratory mice by experimental endometriosis By Nasuhi Engin Aydin

Dr. Taylor group from Yale School of Medicine, New Haven, CT, USA has published their experimental study in the "American Journal of Obstetrics & Gynecology" on atherosclerosis following endometriosis induction in laboratory mice. The basic inflammation process in endometriosis patients…

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No way to sleep when you suffer from pain

No way to sleep when you suffer from pain By Bahar Yuksel

Having chronic disease might alter the sleep quality and disturb sleeping periods. Besides insomnia, endometriosis itself changes the pain sensitivity and increases the body’s reaction to inflammatory and painful inputs. Thus, as a chronic and painful long-term situation, the relation…

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Geography May Influence Risk of Endometriosis

Geography May Influence Risk of Endometriosis By Özge Özkaya

The risk of developing endometriosis seems to be geographically heterogeneous across France, according to results from a study published in the journal Scientific Reports. The study identified  20 high-risk hotspots around the country. These showed similar results for non-adenomyosis endometriosis…

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How possible is it to diagnose endometriosis from a urine sample?

How possible is it to diagnose endometriosis from a urine sample? By Eylül GÜN

The development of non-invasive diagnostic methods in endometriosis is essential for successful surveillance. Various biomarkers have been used for this purpose, including biomarkers from serum, peritoneal irrigation fluid, endometrial tissue biopsy, and urine. Dr. Chen et al. from Taiwan conducted…

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Abdominal wall endometriosis is not a rare disease as supposed

Abdominal wall endometriosis is not a rare disease as supposed By Hale Goksever Celik

Abdominal wall endometriosis is an iatrogenic type of endometriosis defined as the localization of endometrial glandular and stromal tissue on the abdominal wall including skin, the rectus abdominis muscle, and rectus muscle sheath. Cyclical pain, mass located on the abdominal…

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The incidence of ovarian cancer after histologically diagnosed endometriosis.

The incidence of ovarian cancer after histologically diagnosed endometriosis. By Selma Oransay

Ovarian cancer has the highest mortality rate among gynecologic cancers. Furthermore, these patients are generally diagnosed in advanced stage due to their non-symptomatic nature. Therefore, preventative strategies have enormous importance for the management of ovarian cancer.  Dr. Hermens and colleagues…

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How reliable are the patient questionnaires in predicting endometriosis?

How reliable are the patient questionnaires in predicting endometriosis? By Eylül GÜN

It is well known that the diagnosis of endometriosis is delayed in the majority of patients throughout the world. The burden that this brings has many effects on the patients’ lives as well as the society. The radiological developments in…

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Distribution of tubal endometriosis

Distribution of tubal endometriosis By Selma Oransay

The incidence of tubal endometriosis was previously reported in a percentage of 4 to 11, but recent studies gave a prevalence up to 42.5 % which indicates the actual incidence of this disease is underestimated.  Some studies in recent literature…

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A novel contribution to patient management in endometriosis by immunohistochemistry

A novel contribution to patient management in endometriosis by immunohistochemistry By Nasuhi Engin Aydin

Dr. Tarumi and associates from the Kyoto Prefectural University of Medicine, Kyoto, Japan published their retrospective cohort study on the importance of progesterone receptors on recurring ovarian endometriosis in "The Journal of Clinical Endocrinology & Metabolism". Surgery for endometriosis is…

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 Which of the suggested environmental risk factors are indeed related to endometriosis?

 Which of the suggested environmental risk factors are indeed related to endometriosis? By Eylül GÜN

Endometriosis is a complex disease with genetic and environmental factors in its poorly understood pathogenesis. Even though many epidemiological studies in the literature have proposed several risk factors, the lack of clear establishment and modification of these potential risk factors…

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Listening to patients’ complaints is the first step on the way to a diagnosis of endometriosis.

Listening to patients’ complaints is the first step on the way to a diagnosis of endometriosis. By Hale Goksever Celik

Early diagnosis and management of endometriosis are not possible due to the wide spectrum of symptoms and absence of non-invasive diagnostic biomarkers. Particularly the adolescent population is at risk for the diagnostic delay because pelvic pain and dysmenorrhea are very…

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Are the studies based on the nationwide databases more accurate?

Are the studies based on the nationwide databases more accurate? By Eylül GÜN

One of the most common localizations of endometriosis is the ovaries, and therefore, ovarian endometriomas are among the most surgically treated endometriotic lesions. Dr. Roman from Denmark has recently written an editorial about the surgical interventions on ovarian endometrioma and…

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Endometriosis diagnosis and management based on the best available evidence from published literature

Endometriosis diagnosis and management based on the best available evidence from published literature By Selma Oransay

ESHRE, "European Society of Human Reproduction and Embryology" published a Guideline for the diagnosis and treatment of endometriosis in 2005 and then revised it in 2013. Based on new research and development there was a need to renew the last…

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Medicinal Cannabis Use for Endometriosis in Australia and New Zeland

Medicinal Cannabis Use for Endometriosis in Australia and New Zeland By Özge Özkaya

Cannabis use leads to positive outcomes for the management of endometriosis according to the results of an online survey among patients from Australia and New Zealand. These findings, which were published in the journal Cannabis and Cannabinoid Research suggest that…

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Endometriosis information coming from the social media

Endometriosis information coming from the social media   	By Bahar Yuksel

Today’s changing and evaluating world led everything to be lived online. For sure endometriosis and searching for cures or support for endometriosis have been transferred to online social media platforms too. The study conducted by Julian Matthias Metzler et al…

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What are the most common symptoms of endometriosis and how are they related to age?

What are the most common symptoms of endometriosis and how are they related to age? By Eylül GÜN

Even though the incidence of endometriosis is relatively high and numerous studies are being conducted to elucidate its pathogenesis, it is still a highly underdiagnosed and undertreated disease. The symptoms of the disease are well-known; however, the correlation between the…

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A revolutionary view on endometriosis related pain

A revolutionary view on endometriosis related pain By Nasuhi Engin Aydin

Dr. Lydia Coxon and colleagues from Oxford University, UK, have recently published their cross-sectional study on the categorization of endometriosis-related pain in the journal "Frontiers in Pain Research". As a chronic inflammatory condition, endometriosis results in pelvic pain, dysmenorrhea, and…

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Prevalence of endometriosis and adenomyosis by transvaginal ultrasound.

Prevalence of endometriosis and adenomyosis by transvaginal ultrasound. By Selma Oransay

Women who present dyspareunia, dysmenorrhea, dysuria, dyschezia, chronic abdominal, and pelvic pain, and infertility would benefit from the early investigation. If the correct diagnosis of endometriosis and/or adenomyosis can be made in advance, early treatment will improve the quality of…

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Mindfullness Can Hep Reduce Endometriosis Pain

Mindfullness Can Hep Reduce Endometriosis Pain By Özge Özkaya

A brief mindfulness-based intervention can be useful in managing pain related to endometriosis and restoring patients’ psychological well-being, found a new study published in the European Journal of Pain. This finding contributes to the applicability of mindfulness-based interventions in people…

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Planning surgery for recto-sigmoid endometriosis with 3D virtual models.

Planning surgery for recto-sigmoid endometriosis with 3D virtual models. By Selma Oransay

Efforts to reduce the high complication rate of rectosigmoid surgery in deeply infiltrated endometriosis are of great interest to gynecologists. 3D printing, currently used in various surgical specialties to support surgical planning and guide intraoperative procedures may be a way…

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Non-invasive diagnostic tools for endometriosis revisited

Non-invasive diagnostic tools for endometriosis revisited By Nasuhi Engin Aydin

Dr. Signorile and associates from the Italian Endometriosis Foundation have published the results of their retrospective study on a large cohort of endometriosis patients in a recent issue of the periodical, In Vivo. Endometriosis lacks precise scientific knowledge and this brings…

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The underlying reason of implantation failure in women with endometriosis-associated infertility

The underlying reason of implantation failure in women with endometriosis-associated infertility By Hale Goksever Celik

Endometriosis is most frequently encountered in reproductive-aged women, with a prevalence of 10-15% in the general population. However, endometriosis is more frequently diagnosed in infertile women, with a prevalence of 25-40%. Although the exact mechanism explaining the association between endometriosis…

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Cannabis use in the management of endometriosis-related pain during the COVID19 pandemic

Cannabis use in the management of endometriosis-related pain during the COVID19 pandemic By Eylül GÜN

Pain management in endometriosis has been challenging owing to many reasons. Since the pathways that cause pain in endometriosis have not been elucidated extensively, the medical and surgical management of pain remains to be symptomatic. Alternative pain management methods have…

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Prolactin receptor antibodies: A novel treatment proposal for endometriosis

Prolactin receptor antibodies: A novel treatment proposal for endometriosis By Eylül GÜN

Prolactin, a hormone that also acts as a proinflammatory cytokine through its receptor PRLR has been shown to be involved in endometriosis pathogenesis. Previous studies reported that women suffering from endometriosis had elevated prolactin levels. Also, in experimental studies done…

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A French National Study Concerning The "Recovery Protocol" After Deep Infiltrating Endometriosis Surgery.

A French National Study Concerning The By Selma Oransay

In recent years especially for complex surgeries, enhanced recovery after surgery (ERAS) programs have been implemented in several surgical specialties. This is based on a multimodal and multidisciplinary approach centered on the patient’s perioperative situation designed to improve patient management and reduce…

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International Working Group's review on endometriosis classification systems

International Working Group's review on endometriosis classification systems By Nasuhi Engin Aydin

International Endometriosis Working Group including AAGL, ESHRE, ESGE, and WES published a comprehensive review on endometriosis classification, staging, and reporting systems in a recent issue of the journal named "Facts, Views & Vision in Obstetrics and Gynecology". Classification and staging…

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Imaging Techniques Able to Predict Depth of Endometriosis Before Surgery

Imaging Techniques Able to Predict Depth of Endometriosis Before Surgery By Özge Özkaya

Transvaginal ultrasound (TVUS) and pelvic magnetic resonance imaging (MRI) performed by a specialist can accurately predict the depth of rectosigmoid endometriosis before surgery, according to a new study published in the Journal of Minimally Invasive Gynecology. Both approaches are similar…

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A novel scoring tool to standardize surgical complexity for gynecologists.

A novel scoring tool to standardize surgical complexity for gynecologists. By Selma Oransay

The field of gynecologic surgery needs a more comprehensive, objective, and reproducible method for assessing and communicating surgical complexity than the current approach. Actually, there is no formal image-based system that allows surgeons to categorize and communicate the complexity of…

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An important enigmatic promoter of endometriosis: immune dendritic cells

An important enigmatic promoter of endometriosis: immune dendritic cells By Nasuhi Engin Aydin

Dr. Larinha and associates from a Brasilian academic center have published their comprehensive review on the role of immune dendritic cells in the pathogenesis of endometriosis in a recent issue of the "Journal of Reproductive Immunology". Antigen-presenting dendritic cells of…

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A quick insight into the latest research on endometriosis diagnosis and management

A quick insight into the latest research on endometriosis diagnosis and management By Eylül GÜN

Endometriosis research has been expanding with many new studies ranging from new techniques and markers in diagnosis to updates in clinical management and treatment of the disease. The journal Frontiers in Surgery recently brought together articles that reflect important and…

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Immunotherapy in endometriosis: a challenging research topic

Immunotherapy in endometriosis: a challenging research topic By Nasuhi Engin Aydin

Dr. Maksym and associates from academic centers in Poland have published their comprehensive review on endometriosis emphasizing the immunological aspects of the disease in a recent issue of the "Journal of Clinical Medicine". Even though endometriosis is a multifactorial disease,…

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Algorithm for pain management in endometriosis

Algorithm for pain management in endometriosis By Selma Oransay

One of the debilitating symptoms of endometriosis is pain. Mostly due to delayed diagnosis and the high recurrence rate, even after the surgical and hormonal therapy pain control may not be sufficient causing the patient to suffer for decades.  Endometriosis-associated…

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A New Non-Invasive Marker for Endometriosis?

A New Non-Invasive Marker for Endometriosis? By Özge Özkaya

The reactivity of serum immunoglobulin G (IgG) with fucose-specific lectins AAL, LCA, and LTA could be a useful diagnostic biomarker for endometriosis, according to a new study published in the Journal of Inflammation Research. It could also be a clinical…

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Is "non-hormonal therapy" effective in women with endometriosis-associated pain?

Is By Hale Goksever Celik

Women with endometriosis require effective treatment due to the negative impact of the disease on quality of life. Hormonal treatments including oral contraceptives, and progestins are usually recommended to suppress ovulation and decrease pelvic pain. However, some women do not…

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Risk of cardiovascular disease in endometriosis patients

Risk of cardiovascular disease in endometriosis patients By Eylül GÜN

A well-known fact about endometriosis is the inflammatory processes that underlie its pathophysiology. The inflammatory markers have been thought to play a role in many additional disorders in endometriosis patients. One of the primary markers of inflammation is C-reactive protein…

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The consequences of endometriosis on the quality of life

The consequences of endometriosis on the quality of life By Hale Goksever Celik

The most common clinical findings of endometriosis patients are pelvic pain and fertility problems, resulting in impairment of quality of life. These women are affected especially during the menstruation period. Olliges et al., from Germany and Switzerland, published a study…

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Surgery for the Treatment of Endometriosis of the Diaphragm and Thorax

Surgery for the Treatment of Endometriosis of the Diaphragm and Thorax By Özge Özkaya

Diaphragmatic and thoracic endometriosis starts in the abdominal wall of the diaphragm and later invades the thorax, based on findings from a series of patients surgically treated for the disease, reports a study published in the Journal of Gynecology Obstetrics…

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Diaphragmatic defects, liver herniations and catamenial pneumothorax

Diaphragmatic defects, liver herniations and catamenial pneumothorax By Nasuhi Engin Aydin

Dr. Arakawa and associates from The Jikei Katsushika Medical Center, Japan, have published their recent case of catamenial pneumothorax with diaphragmatic defect and liver herniation in the "Journal of Cardiothoracic Surgery". Catamenial pneumothorax is an uncommon condition with a reported…

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Endometriosis of the Diaphragm, What do the Doctors Know About it?

Endometriosis of the Diaphragm, What do the Doctors Know About it? By Özge Özkaya

The median time between the first consultation with a primary care physician and receiving a diagnosis of endometriosis of the diaphragm is two years according to a study by U.K. researchers. In the worse case, it took 23 years for…

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The largest series of diaphragmatic endometriosis

The largest series of diaphragmatic endometriosis By Bahar Yuksel

Diaphragmatic endometriosis is one of the most common extra pelvic endometriosis types, yet the correct incidence is unclear. In the study conducted by Ceccaroni Marcello et al from the International School of Surgical Anatomy, Verona, Italy, the authors analyzed the…

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Diaphragmatic endometriosis

Diaphragmatic endometriosis By Selma Oransay

Diaphragmatic endometriosis is a rare clinical condition that may show signs and symptoms like chest pain, right upper quadrant abdominal pain, shoulder pain, pleuritic pain, hemothorax, pneumothorax, hemoptysis, and thoracic endometriosis syndrome while the major part of the patients is…

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Thoracic endometriosis: the most frequent endometriosis involvement outside abdominopelvic cavity

Thoracic endometriosis: the most frequent endometriosis involvement outside abdominopelvic cavity By Nasuhi Engin Aydin

Six to ten percent of reproductive-age women are affected by endometriosis, and about 12% are estimated to be outside the abdominopelvic cavity - the most frequent location being the thorax. Endometriosis within the pulmonary parenchyma or on the diaphragm and…

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Urinary Tract Endometriosis

Urinary Tract Endometriosis By Bahar Yuksel

Endometriosis is mostly seen in patients of fertile age, and urinary tract endometriosis affects 1.2 to 6% of women with endometriosis. French coloRectal Infiltrating ENDometriosis Study (FRIENDS) group investigated the characteristics of urinary tract endometriosis in 232 patients from 31 centers. Authors…

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Which surgical technique is best for rectal endometriosis?

Which surgical technique is best for rectal endometriosis? By Eylül GÜN

One of the common sites for deep endometriosis is the intestines, with a rate of 3-37%. Intestinal endometriosis constitutes a serious cause of gastrointestinal symptoms, pain, and the alteration of the quality of life, with the rectum and sigmoid colon being…

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Nerve-sparing technique for deep infiltrating endometriosis and its impacts on pelvic organ and sexual functions.

 Nerve-sparing technique for deep infiltrating endometriosis and its impacts on pelvic organ and sexual functions. By Selma Oransay

Deep infiltrating endometriosis and involvement of parametrium cause severe pelvic pain and dysfunction of some pelvic organs resulting in a reduction in women's quality of life. Although surgery for DIE aims to relieve pelvic pain, entering into the posterior parametrial…

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Effects of Bowel Endometriosis Surgery on Mode of Delivery

Effects of Bowel Endometriosis Surgery on Mode of Delivery By Özge Özkaya

Less than a third of doctors counsel women about the possible effects of surgical treatment of bowel endometriosis on their mode of delivery should they become pregnant, according to a new study published in the Journal of Obstetrics and Gynaecology.…

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A comparison of endometriosis Classifications: rASRM, EFI or Enzian?

A comparison of endometriosis Classifications: rASRM, EFI or Enzian? By Selma Oransay

None of the endometriosis classifications provide a clinically valuable system since the very first description of the disease in 1860. One unique terminology to describe the localization and the extension of the disease is needed, which should be the same…

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Egg or chicken, which is causing bladder symptoms, DIE or surgery for DIE?

Egg or chicken, which is causing bladder symptoms, DIE or surgery for DIE? By Bahar Yuksel

Urinary symptoms could be overwhelming and sometimes could be hidden behind pain symptoms, but still might cause secondary damages on kidneys and bladder if remain undetected. In the prospective study conducted by Laterza et al, the authors questioned whether the…

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Surgery before in-vitro fertilization – Is it beneficial in patients with deep endometriosis?

Surgery before in-vitro fertilization – Is it beneficial in patients with deep endometriosis? By Eylül GÜN

Deep pelvic endometriosis is thought to be related to infertility by altering the pelvic environment and anatomy due to pelvic adhesions, and the changes in endometrial receptivity contribute to it. The discussion on whether the surgical intervention was beneficial started…

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Quality of life assessment in women with endometrioma

Quality of life assessment in women with endometrioma By Eylül GÜN

Like most chronic diseases, endometriosis poses a significant risk of diminishing the quality of life in patients suffering from it, particularly with its most considerable symptom; chronic pelvic pain. Although it is known that endometriosis is more common in East…

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Evaluation of daily diary for endometriosis-related pain.

Evaluation of daily diary for endometriosis-related pain. By Selma Oransay

Some endometriosis patient-reported outcomes elements have been previously developed in accordance with regulatory and best practice guidelines including Endometriosis Pain Daily Diary, the Endometriosis Symptom Diary, and Endometriosis Impact Scale. The aim of this study was to develop another content-valid…

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Endometriosis: Beyond the naked eye visibility

Endometriosis: Beyond the naked eye visibility By Bahar Yuksel

The gold standard method for endometriosis diagnosis is histopathologic evaluation of the resected lesions. The study conducted by Sara-Michelle Gratton et al. in Canada evaluated the possible effect of developed laparoscopic skills and equipment on the endometriosis diagnosis, and whether…

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Full understanding the role of nervous system in endometriosis could yield new gateways to novel therapeutic approaches

Full understanding the role of nervous system in endometriosis could yield new gateways to novel therapeutic approaches By Nasuhi Engin Aydin

Dr. Velho and associates from Berlin, Germany have recently published their comprehensive review on the role of the nervous system in endometriosis in a recent issue of “International Journal of Molecular Sciences”. Understanding the role of the peripheral nervous system…

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Endometriosis Seems to Affect The Development of the Embryo

Endometriosis Seems to Affect The Development of the Embryo By Özge Özkaya

Embryos development is impaired in embryos from women with endometriosis found a new study published in the Journal of Assisted Reproduction and Genetics. In spite of this, the outcomes of in vitro fertilization (IVF) are similar for patients with endometriosis…

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Is intrauterine insemination effective in women having endometriosis-associated infertility?

Is intrauterine insemination effective in women having endometriosis-associated infertility?  By Hale Goksever Celik

The most common presenting complaints of women with endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Affected women demand therapy for these symptoms of endometriosis, notably fertility problems. Several underlying mechanisms have been proposed to explain endometriosis-associated infertility including anatomic…

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The necessity of laparoscopy for unexplained infertility.

The necessity of laparoscopy for unexplained infertility. By Selma Oransay

The standard for accepting a couple as "infertile" is the inability to conceive after 12 months of regular unprotected intercourse. When this condition is met, assessing the number of motile sperm in the male partner and certifying the patency at…

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The Role of Endometrial Cytokines on the Infertility in Endometriosis Patients

The Role of Endometrial Cytokines on the Infertility in Endometriosis Patients By Eylül GÜN

The intrauterine microenvironment and underlying immunological mechanisms in endometriosis pathogenesis have been a popular research topic, mainly due to the efforts to comprehend the reason to elucidate infertility that these patients suffer from. Because of their superiority to other immune…

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Association of psoriasis and endometriosis

Association of psoriasis and endometriosis By Selma Oransay

Psoriasis is an immune-mediated inflammatory skin disease characterized by scalpy, red, and well-demarcated skin plaques that are observed in 2-4% of the population. Approximately 30% of psoriatic patients additionally have joint pain, stiffness, and swelling called psoriatic arthritis. The mechanism…

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How likely is it to get pregnant and have a baby after undergoing surgery for high stage endometriosis?

How likely is it to get pregnant and have a baby after undergoing surgery for high stage endometriosis? By Eylül GÜN

As one of the most common causes of infertility in women, endometriosis might be surgically interfered with depending on the stage. For Stage I and II endometriosis, surgery is recommended in the latest guidelines to ameliorate fertility rates, however, there…

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Physical activity and exercise in reducing endometriosis symptoms

Physical activity and exercise in reducing endometriosis symptoms By Eylül GÜN

The treatment modalities to date on endometriosis have focused on the symptomatic relief and management of chronic pain. Hormonal suppression sometimes shows intolerable side effects and is known to lose effect after some time. Surgical interventions may not provide a…

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Is it iron that calls vessels to form endometriosis

Is it iron that calls vessels to form endometriosis By Bahar Yuksel

The trigger mechanism of endometriosis formation is still under investigation. But it is clear that there is an iron overload on endometriotic lesions. In the study conducted by Guojing Li et al, the mechanism of iron on endometriosis formation has been…

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Pain alone is not a specific predictor for endometriosis diagnosis

Pain alone is not a specific predictor for endometriosis diagnosis By Hale Goksever Celik

The most common symptoms and signs of women with endometriosis include dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. However, diagnostic delay still occurs due to the broad clinical spectrum of the disease and the absence of non-invasive diagnostic biomarkers. Gordon et…

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The quality of life and mental health in endometriosis patients

The quality of life and mental health in endometriosis patients By Eylül GÜN

One of the most important aspects of having a chronic illness comes with its relative effect on the patients’ quality of life and mental health status. Being among the most debilitating diseases in women in the reproductive period, endometriosis is…

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How Likely Am I to Conceive After Endometriosis Surgery?

How Likely Am I to Conceive After Endometriosis Surgery? By Özge Özkaya

Women with superficial peritoneal endometriosis and just one type of lesion are more likely to conceive after surgery, according to a new study published in the International Journal of Gynecology and Obstetrics.  This is important because patients will be better…

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From Spain: execution for endometriosis and chronic pelvic pain unresponsive to conventional therapies

From Spain: execution for endometriosis and chronic pelvic pain unresponsive to conventional therapies By Selma Oransay

The current conventional therapy for chronic pelvic pain for endometriosis is defined as either hormonal or non-hormonal medical treatment starting with combined oral contraceptives progestins or dienogest, and then gonadotropin-releasing hormone analogs and/or surgery. Although conventional therapies usually are successful, still…

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The relevance of mitosis in endometriotic tissue biopsies

The relevance of mitosis in endometriotic tissue biopsies By Nasuhi Engin Aydin

Dr. Wetzk and co-workers from the Technical University, Dresden, Germany have published a retrospective study on the diagnostic impact of mitotic activity in the endometriotic lesion biopsies in the recent issue of the journal “Geburtshilfe und Frauenheilkunde”. Guidelines highly recommend a…

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The higher the Endometriosis Fertility Index, the higher the chance of getting pregnant

The higher the Endometriosis Fertility Index, the higher the chance of getting pregnant By Hale Goksever Celik

The women who desire to get pregnant may also suffer from fertility problems depending on several mechanisms such as anatomic distortion, peritoneal adhesions, tubal dysfunction, impaired quality of oocytes, and impaired endometrial receptivity. One of the most important problems in…

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Importance of Language in Communicating Endometriosis Pain

Importance of Language in Communicating Endometriosis Pain By Özge Özkaya

Language is of great importance for women with endometriosis to communicate their pain to their doctor, according to a new study published in Frontiers in Global Women's Health. The study also found that additional tools are needed to help women…

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What do endometriosis and ovarian cancer have in common?

What do endometriosis and ovarian cancer have in common? By Bahar Yuksel

While endometriosis is not a malignant disease, it is for sure known that it shares genetic disorders with cancers. In the bioinformatics study applied by Leyi Ni et al, the researchers analyzed the genetic pathways shared by both ovarian cancers…

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A novel target proposal in endometriosis: Phoenixin

A novel target proposal in endometriosis: Phoenixin By Eylül GÜN

As well as being a hormone-dependent reproductive system disorder, endometriosis is known to be multifactorial, which makes its etiopathogenetic mechanisms even harder to understand. Many new targets have been vastly evaluated with the hope of finding a new diagnostic test…

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A study design to improve the patient-centeredness in endometriosis care.

A study design to improve the patient-centeredness in endometriosis care. By Selma Oransay

It is well known that endometriosis causes impaired daily activity and productivity along with energy loss, fatigue, pelvic pain, deep dyspareunia, and further, infertility accompanies all these negative influences. The chronic nature of the disease forces clinicians to plan long-term care…

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Emotions on the 'Surgery Requirement' in patients with bowel endometriosis

Emotions on the 'Surgery Requirement' in patients with bowel endometriosis By Eylül GÜN

Endometriosis is known to have many adverse effects in patients’ lives such as a significant decrease in the quality of life, psychosocial problems, loss of productivity and focus while working. With the constant chronic pain, the patients mostly present with…

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An Overview on Treatment of endometriosis

An Overview on Treatment of endometriosis By Selma Oransay

There are different guidelines by different gynecological societies for the diagnosis and treatment of endometriosis, which is an extremely complex illness.  Kalaitzopoulos and Samartzis et al. from Switzerland worked on and compared six national and two international widely used guidelines to…

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A trial of exogenous melatonin on dysmenorrhea in women "without endometriosis"

A trial of exogenous melatonin on dysmenorrhea in women By Nasuhi Engin Aydin

In their recent article published in “European Journal of Clinical Pharmacology”,  Dr. Söderman and associates from Stockholm report the results of their randomized, double-blind, placebo-controlled trial on the effects of oral melatonin in women with dysmenorrhea -unrelated to endometriosis-. Melatonin is a hormone…

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New Endometriosis Clinical Trial Now Recruiting Participants

New Endometriosis Clinical Trial Now Recruiting Participants By Özge Özkaya

A new clinical trial investigating the effect of cognitive-behavioral therapy on quality of life in patients undergoing surgery for endometriosis is now recruiting participants. The randomized, controlled trial aims to recruit 100 participants, ages 18 to 50 with proven endometriosis…

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Which one is more effective for the preservartion of postoperative ovarian reserve?

Which one is more effective for the preservartion of postoperative ovarian reserve? By Selma Oransay

Although cystectomy is the most preferred treatment of endometrioma, it is still a matter of debate as it may cause a reduction in the quality and number of remaining follicles, especially important for women who are planning to conceive. Anti-Müllerian…

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Placenta praevia and cesarean section more common in patients with ART for Endometriosis

Placenta praevia and cesarean section more common in patients with ART for Endometriosis By Hale Goksever Celik

Even though endometriosis is known to be associated with infertility, these women still have a chance to get pregnant spontaneously or by assisted reproduction techniques (ART) with the aid of recent technological developments. A It has also been shown that…

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Matrix metalloproteinases and their role in endometriosis

Matrix metalloproteinases and their role in endometriosis By Eylül GÜN

The extracellular matrix harbors important macromolecules such as collagen and glycoproteins which are required for tissue remodeling, differentiation, and homeostasis. The main group of enzymes responsible for these properties is called matrix metalloproteinases (MMPs). It has been proven that MMPs…

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Indocyanin Green dye for recognition of occult endometriotic lesions

Indocyanin Green dye for recognition of occult endometriotic lesions By Bahar Yuksel

The surgery for endometriosis is challenging and the resection of all lesions is not accurately related to not catching all lesions under white light (WL) conventional laparoscopy. In the study conducted by Luigi Carlo Turco et al., in a tertiary…

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Evaluation of patient self-reported outcome measures for endometriosis.

Evaluation of patient self-reported outcome measures for endometriosis. By Selma Oransay

Endometriosis symptomology is multifactorial and it changes over time based on the patient's life experience, perceptions, and medical treatment. These changes require the agility of adaptation for both clinicians and patients to respond properly. The documentation of the patient's specific…

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Efficacy of cannabis on endometriosis symptoms

Efficacy of cannabis on endometriosis symptoms By Eylül GÜN

Endometriosis is related to a wide range of symptoms that affect the quality of life of patients in many aspects. Studies have shown malfunctions in the endocannabinoid system in endometriosis patients which led to the idea to target this pathway…

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Endometriosis and women’s social lives, work and education.

Endometriosis  and women’s social lives, work and education. By Hale Goksever Celik

The women with endometriosis present with a broad clinical spectrum including pelvic pain, dysmenorrhea, dyspareunia, and infertility. All of these symptoms and signs may have a negative impact on women’s lives by having endometriosis. Mastrangelo and Turnbull, from Australia, published…

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Herbicide Alters Immune System on the Route to Endometriosis

Herbicide Alters Immune System on the Route to Endometriosis By Bahar Yuksel

A popular environmental pollutant and herbicide named 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) and its receptor named aryl hydrocarbon receptor (AHR) have been suggested for causing endometriosis, but the mechanism was not clear. In the study conducted by  Mahsa Tanha et…

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Intravascular adenomyomatosis: an important entity to be alert

Intravascular adenomyomatosis: an important entity to be alert By Nasuhi Engin Aydin

Pathologists from Stanford University, USA have recently published four novel cases of intravascular adenomyomatosis co-existing with pelvic endometriosis in a recent issue of “Human Pathology”. Intravascular leiomyomatosis is characterized by the presence of smooth muscle in venous and lymphatic spaces…

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A novel in-vitro endometriosis model with KRAS and PIK3CA mutations

A novel in-vitro endometriosis model with KRAS and PIK3CA mutations By Eylül GÜN

A plethora of research has been ongoing to illuminate the pathogenesis of endometriosis which is a multifactorial disease. These studies have proven the association between some mutated cancer driver genes and endometriosis, and links between certain cancers such as ovarian…

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Is breastfeeding beneficial to endometriosis pain?

Is breastfeeding beneficial to endometriosis pain? By Nasuhi Engin Aydin

Dr. Porta team from Italian academic centers have recently published their research in “International Journal of Environmental Research and Public Health” on breastfeeding mothers who were under follow-up for histologically proven endometriosis. The hormonal milieu is believed to have an important…

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International definition and standardization for endometriosis

International definition and standardization for endometriosis By Selma Oransay

There is huge heterogeneity in classifications, subtypes, diagnostic and therapeutic interventions of endometriosis in published literature. The lack of a uniform and widely accepted terminology of the disease rose the necessity to argue and reach a common consensus with organizations,…

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Preoperative Neutrophil-to-Lymphocyte Ratio for prediction of postoperative pregnancy

Preoperative Neutrophil-to-Lymphocyte Ratio for prediction of postoperative pregnancy By Hale Goksever Celik

Among women with endometriosis, 30 to 50 percent are estimated to have infertility, and 25-50% of infertile patients are found to have endometriosis. Anatomic distortion, diminished tubal peristalsis, diminished sperm movements, dysfunctional folliculogenesis, luteal phase dysfunctions, and alterations in endometrial…

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Relationship Goals and Sexual Satisfaction for Couples Coping with Endometriosis

Relationship Goals and Sexual Satisfaction for Couples Coping with Endometriosis By Selma Oransay

"Relationship satisfaction" is based on an individual's emotional judgment. Physical and emotional obstacles may present and negatively affect relationship satisfaction. Endometriosis is associated with multiple life domains, and also includes relationship and sexual satisfaction. Sexual satisfaction, on the other hand,…

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Cross-cultural translation and adaptation of an endometriosis survey

Cross-cultural translation and adaptation of an endometriosis survey By Eylül GÜN

Endometriosis is a disease that presents heterogeneously which makes it hard to identify a causal relationship. A patient-based questionnaire called Endometriosis Participant Questionnaire (EPQ) has been originated by The World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project. It…

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A plea from pathologists: standardized protocols for adenomyosis and endometriosis  

A plea from pathologists: standardized protocols for adenomyosis and endometriosis   By Nasuhi Engin Aydin

Pathologist Drs. Camboni and Marbaix from Brussels, Belgium published their comprehensive review on adenomyosis and endometriosis titled “Ectopic endometrium: the pathologists’ perspective” in a recent issue of the International Journal of Molecular Sciences. Endometriosis and adenomyosis are well-known entities as…

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The effect of hormone therapy after surgical menopause on endometriosis recurrence

The effect of hormone therapy after surgical menopause on endometriosis recurrence By Selma Oransay

Definitive surgery for severe and advanced endometriosis is hysterectomy with bilateral oophorectomy, which may cause vasomotor symptoms, sleep deprivation, mood change, and dyspareunia in the patients. Furthermore, after the surgical removal of the ovaries, the sudden drop in estrogens causes…

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Does Surgery Improve the Digestive Symptoms of Endometriosis?

Does Surgery Improve the Digestive Symptoms of Endometriosis? By Özge Özkaya

Women with deep infiltrating endometriosis involving the bowels have the most significant improvement in gastrointestinal symptoms following surgery. This is according to the findings of a comparative retrospective study in almost 1,500 women.  “Women with severe bowel symptoms and deep…

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Pharmacological Therapy for Endometriosis Pain

Pharmacological Therapy for Endometriosis Pain By Eylül GÜN

The negative effects of endometriosis on women’s quality of life are indisputable. Women who suffer from endometriosis might have to deal with problems in many aspects such as psychological, sexual, social, and economic. Pain which is one of the most…

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Environmental factors play a role in the development of endometriosis

Environmental factors play a role in the development of endometriosis By Hale Goksever Celik

The proposed mechanisms underlying the development of endometriosis may be classified into three groups: in-situ theory, implantation theories, and induction theories. Genetic, hormonal, environmental, and lifestyle-related factors are also involved as no mechanism is solely responsible for endometriosis development. Although there are…

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The new Endometriosis Surgical Complexity Classification: AAGL 2021

The new Endometriosis Surgical Complexity Classification: AAGL 2021 By Selma Oransay

Multiple endometriosis categorizations have been approved in the recent forty years. The American Fertility Society proposed ASRM with a desire to score the impact of the endometriosis in 1996,  which was updated several times later (rASRM), to predict infertility after laparoscopic operations. For…

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Dietary adjustments do not increase the quality of life of women with endometriosis.

Dietary adjustments do not increase the quality of life of women with endometriosis. By Özge Özkaya

Even though dietary changes do not seem to increase patients’ quality of life, they lead to a perceived reduction in symptoms. No specific adjustment in the diet increases the quality of life of women with endometriosis, according to a new…

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Inflammatory and genetical background of endometriosis may yield new therapeutic approaches

Inflammatory and genetical background of endometriosis may yield new therapeutic approaches By Nasuhi Engin Aydin

Elisa Giacomini and colleagues from medical centers in Milan, Italy have published their review manuscript on the inflammatory and genetical pathogenetic background of endometriosis in a recent issue of  “International Journal of Molecular Sciences”, suggesting also new therapeutic approaches. The inflammatory…

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It is "pain" that causes sleep disturbances and fatigue in endometriosis patients

It is By Bahar Yuksel

Endometriosis has been studied previously about its effects on quality of life and the possible effects on sleeping periods. The study conducted by Federica Facchin et al. questioned the reason for endometriosis to cause sleep disturbance. The authors have divided…

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How does adenomyosis affect IVF outcomes?

How does adenomyosis affect IVF outcomes? By Hale Goksever Celik

Adenomyosis is defined as the localization of endometrial tissue in the muscle layer of uterus. Several theories have been proposed to explain the reasons of adenomyosis-associated infertility including uterine dysperistalsis, abnormal transportation of sperm in the uterine cavity, and embryo…

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Green tea as a therapeutic agent in endometriosis

Green tea as a therapeutic agent in endometriosis By Eylül GÜN

Tea is among the most consumed beverages all around the world. It has many kinds which originate from the same plant “Camellia sinensis” but differ in color after the fermentation process. Green tea is the one produced right after the…

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Molecular alterations in endometriosis pathogenesis

Molecular alterations in endometriosis pathogenesis By Eylül GÜN

Endometriosis has been in our lives for decades, however little is known about its pathogenesis making it hard to diagnose and manage. A review study conducted by Balasubramanian et al. from India reveals all the characteristics and the underlying conditions…

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Phytoestrogens could have promising effects in endometriosis management

Phytoestrogens could have promising effects in endometriosis management By Nasuhi Engin Aydin

Dr. Bartiromo and associates from Milan, Italy published a systematic review on phytoestrogens and endometriosis in the periodical “Nutrients”. Endometriosis has features of chronic inflammation based on uncontrolled hormonal response and immune-mediated dysfunctions. Estrogens are endocrine and paracrine agents that could yield…

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Complex Relation Between Body mass index and endometriosis

Complex Relation Between Body mass index and endometriosis By Selma Oransay

This research aimed to find the relationship between BMI and endometriosis especially related to surgical phenotype and lesion location. An observational cohort study was led by  Holdsworth-Carson et al, from Australia. The article was recently published in "RBMO" . Many earlier studies report…

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Urinary Function Alterations after Surgery for Deep Endometriosis.

Urinary Function Alterations after Surgery for Deep Endometriosis. By Selma Oransay

Laparoscopic surgery is a mainstay therapy for symptomatic patients with DE. Although our findings of improvement in many domains of urinary function are encouraging, postoperative deterioration in urinary function was found for patients with initial normal function. More research is…

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Resveratrol for endometriosis

Resveratrol for endometriosis By Bahar Yuksel

Endometriosis has been studied previously about its inflammatory nature and its tendency for causing macrophage disfunction. In the study conducted by Chunyan Wang et al, the researchers analyzed the effect of a flavonoid, "resveratrol" on endometriosis lesions and the mechanism…

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The comparison of the effect of hemostatic techniques on ovarian reserve during endometrioma cystectomy

The comparison of the effect of hemostatic techniques on ovarian reserve during endometrioma cystectomy By Hale Goksever Celik

The possible negative effect of the surgical excision of endometriomas on the ovarian reserve has brought up the meticulous implementation of the decision for surgical approach. Dr. Raquel Silveria da Cunha Araujo et al, from Brazil, published a study titled as…

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Endometriosis, pelvic inflammatory disease and ovarian cancer

Endometriosis, pelvic inflammatory disease and ovarian cancer By Eylül GÜN

Endometriosis is a locally aggressive and chronic inflammatory disease and it is now known that with various genetic pathways it creates susceptibility to certain cancers, the most common being ovarian cancer. Pelvic inflammatory disease on the other hand creates a…

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Persistence of Chronic Pelvic Pain after Hysterectomy

Persistence of Chronic Pelvic Pain after Hysterectomy By Hale Goksever Celik

Chronic pelvic pain is defined as the "pain in the pelvic area that lasts for 6 months or longer". There are several gynecological, urological, and gastrointestinal reasons for the development of chronic pelvic pain. Nociceptive pain or central sensitization is…

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Assisted Reproductive Technology Outcomes in Women with and without Endometriosis

Assisted Reproductive Technology Outcomes in Women with and without Endometriosis By Selma Oransay

Endometriosis causes infertility in one-third of patients, while in approximately 25-35% of infertile women, the cause is endometriosis.  The primary interest and the question of Moss et al. from the University of Queensland, Brisbane, Australia was "the differences in the…

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Etiopathogenesis of Endometriosis and Links with Endometrial Cancer

Etiopathogenesis of Endometriosis and Links with Endometrial Cancer By Nasuhi Engin Aydin

Professor Terzic and colleagues from the Medical School of Nazarbayev University, Kazakhstan published their review on the molecular aspects of endometriosis and endometrial cancer in “International Journal of Molecular Sciences”. The etiopathogenesis of endometriosis has remained controversial, with recent studies…

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How to Reduce Pain After Laparoscopic Surgery

How to Reduce Pain After Laparoscopic Surgery By Özge Özkaya

Using humidified warm gas with forced-air warming blanket during laparoscopic surgery resulted in significantly less pain in the recovery room, according to a new study published in the journal "Surgical Endoscopy". In patients with endometriosis, using humidified warm air even…

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Routine preoperative ureteral stent and complications in Deep Infiltrating Endometriosis

Routine preoperative ureteral stent and complications in Deep Infiltrating Endometriosis By Bahar Yuksel

Deep infiltrative endometriosis is a devastating disease that includes both anterior and posterior compartments, and ureteral infiltration with endometriotic nodules affects 1 to 6% of all deep infiltrative endometriosis patients. In the study conducted by Giulia Borghese et al., the…

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Lead and cadmium exposures of female workers should be reduced as much as possible

Lead and cadmium exposures of female workers should be reduced as much as possible By Nasuhi Engin Aydin

Min-Gi Kim and associates from Korea published their results on the possible effects of lead and cadmium exposure in endometriosis induction and severity in a recent issue of “International Journal of Environmental Research and Public Health”. Endometriosis is an illness…

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Impact of surgery before IVF in infertile women with endometrioma

Impact of surgery before IVF in infertile women with endometrioma By Hale Goksever Celik

Among the women with endometriosis, 30 to 50% are estimated to have infertility. On the contrary, among women who present with infertility, 25 to 50% are estimated to also have endometriosis. Several mechanisms have been proposed to explain the association…

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Small chain fatty acids produced by gut microbiota: Could that be the missing milestone for endometriosis

Small chain fatty acids produced by gut microbiota: Could that be the missing milestone for endometriosis By Bahar Yuksel

Endometriosis is a worldwide problem but still, the underlying mechanism and optimal treatment options are controversial. In the study conducted by Sangappa B Chadchan et al., the researchers investigated the possible relationship between gut microbiota and endometriosis. A study published…

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Ovarian cancer risk in endometriosis and adenomyosis

Ovarian cancer risk in endometriosis and adenomyosis By Eylül GÜN

Through the historical development of the nomenclature for endometriotic tissue found inside and/or outside the uterus, many terminologies have been used. The accepted terminology is still the one introduced by Sampson: “Endometriosis”. “Adenomyosis” also known as “endometriosis interna” which is…

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Uterine cancer risk in "endometriosis" and "adenomyosis"

Uterine cancer risk in By Selma Oransay

Adenomyosis and endometriosis share similar characteristics, and endometriosis is reported to have an increased risk of ovarian cancer. However, the risk of uterine cancer is not clear yet. Hermens and colleagues from Catharina Hospital, from the Netherlands, designed a population-based…

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Endogenous cannabinoids are related to endometriosis pain

Endogenous cannabinoids are related to endometriosis pain By Eylül GÜN

Pain, specifically dysmenorrhea is the most important symptom of endometriosis. Prostaglandins are the main director of the pain process in dysmenorrhea, therefore the mechanisms affecting the prostaglandin metabolism have been studied in order to find a treatment for pain, and found that…

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Dienogest treatment increases the risk of Endometriosis reoperation rate

Dienogest treatment increases the risk of Endometriosis reoperation rate By Selma Oransay

The common and accepted therapy of endometriosis is surgery, however medical treatment such as nonsteroidal anti-inflammatory drugs, gonadotropin-releasing hormone agonists, oral contraceptives and oral progestins are used for either relieving pain or to prevent recurrences and reoperation. Due to bone loss and…

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Body Mass Index and indicators of metabolic syndrome in women with Endometriosis

Body Mass Index and indicators of metabolic syndrome in women with Endometriosis By Hale Goksever Celik

Endometriosis is a disease of reproductive-aged women and has common pathophysiological mechanisms with other chronic health morbidities due to its estrogen-dependent chronic inflammatory background. The changes in the inflammatory components of adipose tissue may have an impact on the quality of…

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Potential new Target to Reduce Endometriosis Pain

Potential new Target to Reduce Endometriosis Pain By Özge Özkaya

The inflammatory mediators, bradykinin, and bradykinin B1 receptor may play a role in the onset of endometriosis-associated pain according to a new study by Chinese researchers. They do so by inducing the prostaglandin signaling pathway. Therefore, targeting these biological pathways…

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Best practice: How to reduce intraoperative bleeding?

Best practice: How to reduce intraoperative bleeding? By Selma Oransay

Although laparoscopic hysterectomy is a popular and common approach for removing benign uterine lesions, some technical steps especially concerning uterine artery closure depend on the surgeon's preference. Uterine artery ligation may be performed either at the uterus level, which is common…

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A new "survey-based" endometriosis diagnostic tool

A new By Bahar Yuksel

Endometriosis is a disease that is diagnosed years after its appearance which causes life quality impairment to patients. It is crucial for the patient to find out the probability of the presence of endometriosis, for applying to healthcare providers before…

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Altered Decidualization and Pregnancy Complications

Altered Decidualization and Pregnancy Complications By Nasuhi Engin Aydin

Dr. Carlo Ticconi and colleagues from Italy published their comprehensive review manuscript “Clinical consequences of defective decidualization” in the June 2021 issue of “Tissue and Cell”. Currently, there has been growing research interest in the study of decidualization, and knowledge of…

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Catching endometriosis from the front line: educating general practitioners

Catching endometriosis from the front line: educating general practitioners By Bahar Yuksel

It should be repetitively pronounced that "endometriosis is very common and it is very important to diagnose it as soon as possible before it causes lifelong damage to women’s lives". The sooner the better concerning the diagnosis, and this is…

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A rare complication of  endometriosis

A rare complication of  endometriosis By Selma Oransay

Morales et al. from the Monterrey School of Medicine, Mexico, reported a case of bowel intussusception in a woman with severe endometriosis to draw attention to this very rare endometriosis complication. The case is a 27 years old young female…

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Not all endometriotic lesions behave similar to the eutopic endometrium

Not all endometriotic lesions behave similar to the eutopic endometrium By Eylül GÜN

The most widely accepted theory of endometriosis pathophysiology is Sampson’s theory of retrograde menstruation which suggests the ectopic lesions undergo the same hormonal and morphological changes as eutopic endometrium during the menstrual cycle. Recent studies have shown that only a…

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Research Identifies New Genes That Could Be Targeted to Treat Endometriosis

Research Identifies New Genes That Could Be Targeted to Treat Endometriosis By Özge Özkaya

Researchers identified three new genes that could help understand the invasiveness of endometriosis. They also identified one new gene that could be related to the recurrence of the disease. These genes may potentially be new therapeutic targets for endometriosis. In…

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Awareness is the first step toward endometriosis treatment

Awareness is the first step toward endometriosis treatment By Dr. Youngran Park

We want to reiterate the importance of endometriosis, by handling the paper entitled "Endometriosis awareness: screaming at the top of our voices" published on April 2021 in the journal “Women & Health”. The Endometriosis Awareness Month of 2021 was a little different,…

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A new "nonhormonal" treatment target in endometriosis

A new By Eylül GÜN

Endometriosis is a chronic inflammatory condition that affects millions of women globally. With pelvic pain being its most common symptom, the cost of the treatment of disease-associated symptoms has been found to be almost as high as type 2 diabetes.…

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The incidence of endometriosis may vary over time according to age, period and cohort

The incidence of endometriosis may vary over time according to age, period and cohort By Hale Goksever Celik

Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. Early diagnosis has importance as endometriosis impairs the quality of life of patients and creates a serious social and economic burden. Fortunately, earlier diagnosis and management of endometriosis becomes…

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A new assessment tool for the multi-dimensional burden of endometriosis

A new assessment tool for the multi-dimensional burden of endometriosis By Eylül GÜN

Endometriosis is a disease that has multiple effects on patients’ lives in various ways. The quality of life, the status of the patient’s relationships, the continuity and productivity in the patient’s education and work environment, and psychological, emotional, and even…

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Ovarian Cancer Survival in the presence of Endometriosis

Ovarian Cancer Survival in the presence of Endometriosis By Özge Özkaya

Women with ovarian cancer and histologically proven endometriosis have longer overall survival compared to those with ovarian cancer but no endometriosis, found a study published in the American Journal of Obstetrics & Gynecology.  “[…] Women diagnosed as having ovarian cancer…

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The added value of transvaginal hydro-laparoscopy for infertile women

The added value of transvaginal hydro-laparoscopy for infertile women By Selma Oransay

The added value of invasive diagnostic laparoscopy has been questioned, postponed by the increased usage of ultrasonography for the evaluation of infertile patients. Gordts et al. from Life Expert Center, Leuven, Belgium have been working on an alternative way called "transvaginal hydro-laparoscopy" to…

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The role of physical examination and interview in Endometriosis Diagnosis

The role of physical examination and interview in Endometriosis Diagnosis By Bahar Yuksel

Today we know that the most accurate diagnosis of endometriosis necessitates surgery and histopathological examination of the excised lesions. However, many women are misdiagnosed due to various symptoms of endometriosis which mystify gastrointestinal, urinary, and musculoskeletal diseases. Nawrocka-Rutkowska and colleagues…

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The incidence and prevalence of endometriosis in a United States population-based study .

The incidence and prevalence  of endometriosis in a United States population-based study . By Selma Oransay

To define the accurate incidence and prevalence estimates of endometriosis among nonselected cohorts in the USA, Christ et al. from the Departments of Obstetrics and Gynecology of the University of Washington, Seattle, planned a retrospective cohort study using the electronic KPWA…

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Long noncoding RNAs to predict the endometriosis recurrence

Long noncoding RNAs to predict the endometriosis recurrence By Hale Goksever Celik

Despite extensive research, the exact pathophysiologic mechanism of endometriosis remains unclear; and the absence of non-invasive biomarkers to diagnose endometriosis is still a big problem both for clinicians and patients. The recurrence of endometriosis is another challenge that is difficult…

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Endometriosis & adolescents: Overcoming the diagnostic delay via education

Endometriosis & adolescents: Overcoming the diagnostic delay via education By Eylül GÜN

Although the diagnosis of endometriosis is still not timely even in adults, due to its common under- or misdiagnosis in adolescents, the diagnostic delay may further cause the adolescent women to wait to seek medical treatment.  A group of researchers…

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Chemical Found in Self-Care Products May Be Linked to Endometriosis

Chemical Found in Self-Care Products May Be Linked to Endometriosis By Özge Özkaya

There may be a link between exposure to phthalates and endometriosis according to a new study published in the Journal of Assisted Reproduction and Genetics. Although more research is needed, these findings could be translated into clinical practice according to…

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Transvaginal Ultrasound Accuracy for Uterosacral Ligament, Torus Uterinus and Posterior Fornix Endometriosis

Transvaginal Ultrasound Accuracy for Uterosacral Ligament, Torus Uterinus and Posterior Fornix Endometriosis By Selma Oransay

The accuracy of transvaginal ultrasonography for the diagnosis of deep endometriosis depends on the location. The sensitivity is up to 80% when the lesion is in the rectosigmoid, but it decreases up to 66% for the detection of posterior vaginal…

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The clues for pain and infertility in endometriosis/adenomyosis complex

The clues for pain and infertility in endometriosis/adenomyosis complex By Nasuhi Engin Aydin

Drs. Gruber and Mechsner from Charite University-Berlin, Germany published their comprehensive review on pathophysiological background of endometriosis and adenomyosis in the scientific periodical “Cells”. Chronic pain and fertility problems are the main clinical issue in endometriosis and adenomyosis patients. In order to…

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Technical Facts for the Prevention of Complications After Deep Endometriosis Surgery

Technical Facts for the Prevention of Complications After Deep Endometriosis Surgery By Özge Özkaya

There are no differences in the risk of rectovaginal fistula in women with rectovaginal endometriosis who were managed by a liberal or restrictive policy of preventive stoma according to a study by French researchers published in the Journal of Minimally…

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Non-pharmacological self-care: dietary modifications in women with endometriosis.

Non-pharmacological self-care: dietary modifications in women with endometriosis. By Selma Oransay

The academic interest on the role of diet in endometriosis has grown due to its possible relation with inflammation, estrogenic activity, and menstrual cycles. Multiple dietary strategies and prescriptions are being used to deal with the pelvic pain and gastrointestinal…

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How to measure the length of recto-sigmoid deep endometriosis reliably?

How to measure the length of recto-sigmoid deep endometriosis reliably? By Eylül GÜN

An in-depth assessment is needed when rectosigmoid deep endometriosis is decided to be treated surgically. Surgery carries a lot of risks and it is not always easy to decide which procedure the patient would benefit the most from. Patient-oriented surgical…

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A scoping review proposal for the diagnostic and treatment delay of endometriosis

A scoping review proposal for the diagnostic and treatment delay of endometriosis By Hale Goksever Celik

Women with endometriosis suffer from pain for a prolonged time due to diagnostic and treatment delay which is the most challenging aspect of endometriosis. Cromeens et al, from the USA, published a review entitled “Timing, delays, and pathways to the…

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Strong Geographical Gradient in Endometriosis Incidence Identified

Strong Geographical Gradient in Endometriosis Incidence Identified By Özge Özkaya

The geographical distribution of new endometriosis cases showed a very strong north-south spatial gradient in the highly industrialized Friuli Venezia Giulia region of Italy, according to a new study published in the International Journal of Environmental Research and Public Health. “The cluster of…

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Not just the pain stops but also the bowel function improves after DIE surgery

Not just the pain stops but also the bowel function improves after DIE surgery By Bahar Yuksel

Bowel endometriosis and the techniques to operate it have always been a challenge. The study conducted by Beraldo et al., from Brazil, highlighted the results of an effective nerve-sparing bowel surgery on endometriosis lesions and its long-term effects on patients. The…

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Exploring a bonafide biomarker to predict endometriosis

Exploring a bonafide biomarker to predict endometriosis By Eylül GÜN

Endometriosis is a complex disease affecting many women in the reproductive age group. As it is important to figure out the mechanisms responsible for the disease, it is also crucial to identify biomarkers that can be used in the diagnosis…

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Promising therapeutic results in experimental endometriosis model

Promising therapeutic results in experimental endometriosis model By Nasuhi Engin Aydin

Tiziana Genovese and associates from Italian academic centers reported their pioneering findings in an experimental model of endometriosis administering an anti-tumor agent and glucocorticoid combination, published in the scientific periodical “International Journal of Molecular Sciences”. Endometriosis is a worldwide common disease…

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It is not that simple: endometriomas are almost never alone

It is not that simple: endometriomas are almost never alone By Bahar Yuksel

Endometriomas are the widely and easily diagnosed type of endometriosis. They are usually treated by gynecologic surgeons and are thought to be alone most of the time. The study conducted by Piriyev et al highlighted the coexistence of extraovarian endometriosis…

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Is the presence of nerve fibers in the endometrium associated with endometriosis?

Is the presence of nerve fibers in the endometrium associated with endometriosis? By Eylül GÜN

Endometriosis is a common disease in reproductive women and diagnostic imaging have a limited role in its diagnosis. The gold standard diagnostic method remains to be the histopathological examination of the tissue obtained via laparoscopy. One of its most common…

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Resveratrol, isoflavones and puerarin have favorable in vivo results in endometriosis studies

Resveratrol, isoflavones and puerarin have favorable in vivo results in endometriosis studies By Nasuhi Engin Aydin

Xia Cai and associates from research units located in China published their review article on the relationship between phytoestrogens and endometriosis in the scientific periodical named “Pharmacology”. The great variation in the prevalence of endometriosis raises questions in regard to…

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Endometriosis and Rheumatoid Arthritis, Could There Be a Link?

Endometriosis and Rheumatoid Arthritis, Could There Be a Link? By Özge Özkaya

Patients with endometriosis have a higher risk of rheumatoid arthritis according to a study published in the journal Rheumatology. This finding suggests that rheumatologists should be especially mindful of the possibility of underlying endometriosis when treating women with rheumatoid arthritis.…

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Postoperative Opioid use after Robotic operations for endometriosis, compared to non-endometriosis

Postoperative Opioid use after Robotic operations for endometriosis, compared to non-endometriosis By Bahar Yuksel

Endometriosis is a common disease in patients of fertile age, and many patients require surgery. Robotic surgery is accepted as a minimally invasive method in the management of endometriosis and other benign conditions. However, postoperative pain status and the best pain…

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Ureteral endometriosis and its management

Ureteral endometriosis and its management By Eylül GÜN

Urinary tract endometriosis prevalence is hard to determine since almost half of the women with this condition appear asymptomatic. The most common form is bladder endometriosis followed by ureteral endometriosis which is seen more rarely. Ureteral endometriosis is usually located…

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Does hyaluronic acid have a role in endometriosis?

Does hyaluronic acid have a role in endometriosis? By Nasuhi Engin Aydin

Pei-Hsiu Yu and associates from Tainan, Taiwan, published their results of original research on the role of hyaluronic acid in endometriosis formation in a recent issue of  "Taiwanese Journal of Obstetrics and Gynecology". Hyaluronic acid, a glycosaminoglycan protein in the…

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Medical Examination Reduces Anxiety in Women With Suspected Endometriosis

Medical Examination Reduces Anxiety in Women With Suspected Endometriosis By Özge Özkaya

Anxiety levels go down after medical examination in women with suspected endometriosis, found a study by Italian researchers that was published in the Journal of Psychosomatic Research. This was especially pronounced in women who had higher baseline distress and who…

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Analyses of the main classification systems of endometriosis in terms of utrasound, MRI and surgery

Analyses of the main classification systems of endometriosis in terms of utrasound, MRI and surgery By Selma Oransay

Several classifications made by gynecologists, image readers, and radiologists lead to confusion while describing the situation and estimating the progress of endometriosis. Daniela Fischerova team from the Charles University of Prague, Czech Republic, analyzed the main classifications of endometriosis in three…

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Does exercise have an effect on pain perception in women with endometriosis?

Does exercise have an effect on pain perception in women with endometriosis? By Hale Goksever Celik

Endometriosis is an inflammatory disease causing pain symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain, and also infertility. Several medical and surgical treatment options have been developed to improve quality of life of these women. Despite extensive research, the optimal…

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MicroRNAs in the pathogenesis of endometriosis and infertility

MicroRNAs in the pathogenesis of endometriosis and infertility By Eylül GÜN

The gold standard in the diagnosis of endometriosis is laparoscopy and histopathological diagnosis, however search for a non-invasive method has been ongoing. Some biomarkers such as Cancer Antigen 125 have been thought to be useful, but because of their low…

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A hot research topic: macrophage reprogramming for endometriosis treatment

A hot research topic: macrophage reprogramming for endometriosis treatment By Nasuhi Engin Aydin

 Daria Artemova and colleagues from several research institutes of the Russian Federation have published their review on the cellular aspects of endometriosis related to macrophages, particularly emphasizing  promising therapeutic options for the future in "International Journal of Molecular Sciences". Macrophages have…

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The Severity of Pain Does not Predict Endometriosis or its Stage, Study Confirms

The Severity of Pain Does not Predict Endometriosis or its Stage, Study Confirms By Özge Özkaya

The intensity of pain a woman experiences could predict whether or not she would undergo laparoscopic surgery. However, it could not predict whether she has endometriosis or in case she did, the severity of her disease. This is according to…

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The relationship between microbiota and endometriosis

The relationship between microbiota and endometriosis By Eylül GÜN

Endometriosis is a multifactorial and complex disease that results in an inflammatory state. This persistent inflammatory state is known to cause immune dysregulation. In the immunopathogenesis of endometriosis, activated macrophages, increased neutrophils, impaired natural killer cells, altered T-cell differentiation, and…

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Predictors for achieving pregnancy in patients with adenomyosis and endometriosis

Predictors for achieving pregnancy in patients with adenomyosis and endometriosis By Bahar Yuksel

Adenomyosis and endometriosis are benign conditions, however, both situations are associated with deterioration of life quality, a requirement of hospital administrations, and infertility. Laparoscopic surgery is the main treatment option especially for women who desire pregnancy. Shi and colleagues aimed…

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A pictorial overview of abdominal wall endometriosis

A pictorial overview of abdominal wall endometriosis  By Hale Goksever Celik

Abdominal wall endometriosis is the most frequent location of extrapelvic endometriosis, and defined as the presence of ectopic endometrial tissue between the peritoneum and the skin through the abdominal wall. Although obstetric or gynecologic surgical history is indispensable for the…

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New molecular insights in endometriosis pathogenesis

New molecular insights in endometriosis pathogenesis By Nasuhi Engin Aydin

Dr. Rosalba Siracusa and associates from Messina University, Italy, have published their research on cellular pathogenesis of experimental endometriotic lesions in the recent issue of the "International Journal of  Molecular Sciences". Endometriosis is a debilitating chronic estrogen-dependent inflammatory condition and…

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Outcomes of chronic pelvic pain of endometriosis after laparoscopic surgery

Outcomes of chronic pelvic pain of endometriosis after laparoscopic surgery By Selma Oransay

The prevalence of endometriosis is up to 35-50% among patients with pelvic pain. Among several medical and surgical options to relieve chronic pelvic pain, surgical options are the preferred method but this depends on patients' age, fertility desire, and disease…

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How Does Endometriosis Affect Patients Quality of Life?

How Does Endometriosis Affect Patients Quality of Life? By Özge Özkaya

Health-related quality of life is significantly lower in patients with endometriomas or deep infiltrating endometriosis compared to women without the disease. This is according to the results of a recent study in adult Spanish women that was published in the "International…

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Postoperative ovulation induction in infertile women with minimal to mild endometriosis

Postoperative ovulation induction in infertile women with minimal to mild endometriosis By Hale Goksever Celik

Infertility is an important problem that is encountered in 30-50% of women with endometriosis. Several etiopathogenetic mechanisms for the development of reproductive problems in women with endometriosis have been proposed including abnormal peritoneal microenvironment, ovarian dysfunction and/or decreased oocyte quality,…

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Combined contraceptive pills and immune system cells in the endometriotic cyst wall

Combined contraceptive pills and immune system cells in the endometriotic cyst wall By Nasuhi Engin Aydin

Dr. Wanwisa Waiyaput and associates from Mahidol University, Bangkok, Thailand, have published their results on the immune regulatory cells of the surgically resected endometriotic cyst walls in the “Journal of Ovarian Research”. The defective immune response is believed to have…

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Is the information on Facebook groups about endometriosis accurate?

Is the information on Facebook groups about endometriosis accurate? By Eylül GÜN

The use of social media platforms has been increasing day by day. The coronavirus pandemic has attributed to this immensely. Facebook pages and groups are among the most commonly used platforms to share knowledge, seek emotional support, and learn. While…

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Adhesion Barrier Helps After Endometriosis Surgery

Adhesion Barrier Helps After Endometriosis Surgery By Özge Özkaya

An adhesion barrier, named "4DryField® PH" significantly reduced the formation of adhesions following endometriosis surgery, according to a new study by German scientists.  The formation of adhesions following endometriosis surgery is a severe problem that affects 90% of patients. The…

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Women reject using hormonal drugs for endometriosis, an accelerating need for nonhormonal medications

Women reject using hormonal drugs for endometriosis, an accelerating need for nonhormonal medications By Bahar Yuksel

Although the pathophysiology of endometriosis is poorly understood, endocrine drugs are widely used for reducing inflammation and patients’ symptoms. Burla and colleagues aimed to evaluate the patients’ thoughts and expectations about the endocrine drugs which are used in the treatment…

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Managing Persistent Pelvic Pain in a distinct "pain" clinic

Managing Persistent Pelvic Pain in a distinct By Selma Oransay

Persistent pelvic pain is an important problem producing physiological stress and productivity loss during the reproductive period of women. A specific pelvic pain clinic named "Mater Health Persistent Pelvic Pain Clinic" was established in 2017 in a part of the emergency…

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Retinol-binding protein in endometriosis pathogenesis

Retinol-binding protein in endometriosis  pathogenesis By Nasuhi Engin Aydin

Dr. Jae Chul Lee and associates from the Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, have published the recent results of their research on endometriosis regarding the role of retinol-binding protein4…

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What causes distress in women with endometriosis?

What causes distress in women with endometriosis? By Eylül GÜN

Endometriosis is a disease that affects a woman’s life from many different aspects; emotionally, sexually, and physiologically. With the burden of the distress caused by the disease, most women suffer from anxiety and depression. This results in lower self-esteem and…

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The Surgical Management of Endometriosis of the Ureter and Bladder

The Surgical Management of Endometriosis of the Ureter and Bladder By Özge Özkaya

Laparoscopic surgery is feasible and safe to manage endometriosis of the ureter and bladder, according to a new study published in the Journal of Minimally Invasive Gynecology. According to the authors of the study, ureteral resection is more strongly associated…

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Factors affecting complications and the recurrence of operated deep infiltrating endometriosis

Factors affecting complications and the recurrence of operated deep infiltrating endometriosis By Selma Oransay

Deep infiltrating endometriosis is classified as penetrating the endometrial tissues more than 5 mm deep on the peritoneal surface, mainly uterosacral ligament, rectovaginal septum, ovarian fossa, pelvic peritoneum, bowels, ureters, and bladder. Treatment of the disease depends on the need…

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The higher the cyst fluid iron concentration, the more severe the pain symptom for endometrioma

The higher the cyst fluid iron concentration, the more severe the pain symptom for endometrioma By Hale Goksever Celik

Endometriosis usually is encountered in three different forms: superficial peritoneal endometriosis, ovarian cysts (endometrioma) and deep infiltrating endometriosis. Endometrioma can be identified as cystic lesions consisting of dark brown endometrial fluid and are sometimes referred to as "chocolate cysts." The presence…

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Patient- centeredness in endometriosis

Patient- centeredness in endometriosis By Bahar Yuksel

Endometriosis is common in fertile age, and women with endometriosis are suffering from serious symptoms including pelvic discomfort, dysmenorrhea, and infertility. Due to resemblances of endometriosis symptoms with other diseases, most endometriosis patients are faced with delays in diagnosis. To…

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Migraine, endometriosis and plasma "Calcitonin Gene-Related Peptide"

Migraine, endometriosis and plasma By Eylül GÜN

Calcitonin gene-related peptide (CGRP) is a neurotransmitter that takes part in migraine and is now thought to have a role in endometriosis. The role of CGRP is well known in migraine, it is released from neurons during acute attacks and…

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Vulvo- Perineal Endometriosis: From diagnosis to treatment

Vulvo- Perineal Endometriosis: From diagnosis to treatment By Bahar Yuksel

Vulvo- Perineal endometriosis is a very rare condition that should be kept in mind to be diagnosed and treated. Due to its very rare occurrence, most of the information in the literature on vulvo-perineal endometriosis is based on case reports…

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The need for the standardization of diagnostic protocols for "adenomyosis"

The need for the standardization of diagnostic protocols for By Nasuhi Engin Aydin

Dr. Squillace and associates from Brasilian Academic and Health Centers published their paper titled “Adenomyosis and in vitro fertilization impacts- a literature review” in a recent issue of "JBRA Assisted Reproduction". As common gynecological ailment adenomyosis frequently coexists with endometriosis.…

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The effect of COVID-19 pandemic on patients with endometriosis

The effect of COVID-19 pandemic on patients with endometriosis By Bahar Yuksel

COVID-19 pandemic and related conditions, including transport restrictions, social isolation, and difficulties accessing the professional health system, affected many women’s healthcare and daily routine. Evans and colleagues investigated the impact of COVID-19 and COVID-19 related parameters on endometriosis patients’ health…

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The genomic linkage between ovarian cancer and endometriosis

The genomic linkage between ovarian cancer and endometriosis By Eylül GÜN

Endometriosis has been proven to be the precursor of ovarian clear cell and endometrioid carcinomas, however, it is not well understood why and how endometriosis goes into malignant transformation.  To address this issue, in their review article, Dr. Yachida and…

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How to predict the complications after laparoscopic bowel resection in women with endometriosis

How to predict the complications after laparoscopic bowel resection in women with endometriosis By Hale Goksever Celik

The endometriotic lesions infiltrating the bowel wall more than 5 mm. are called "deep infiltrating endometriosis". The patients having bowel involvement may have constipation, diarrhea, tenesmus, or rectal bleeding. Surgical management is the main treatment modality to provide benefits on pain, infertility,…

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Endometriosis from the "EVOLUTIONARY" point of view

Endometriosis from the By Nasuhi Engin Aydin

Natalie Dinsdale and associates from the Canadian Simon Fraser University Department of Biological Sciences published a critical review titled “ The evolutionary biology of endometriosis” in a recent issue of the journal “Evolution, medicine and public health”. This review focuses…

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The Communication Gap Between Specialists for Endometriosis Diagnosis and Management

The Communication Gap Between Specialists for Endometriosis Diagnosis and Management By Eylül GÜN

An approach to help the different specialties which work as a team but lack sufficient communication in endometriosis management build better communication was proposed by Leonardi et al. from Australia and Canada in their opinion article which was published in…

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Endometriosis alters women’s self-behavior

Endometriosis alters women’s self-behavior By Bahar Yuksel

Endometriosis diagnosis is given to almost 15% of women of reproductive age. Although endometriosis could be asymptomatic, many women with endometriosis are faced with several symptoms including chronic pelvic pain, dysmenorrhea, dyspareunia, dyschezia, dysuria, and infertility. The wide variability of…

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Evaluation of preoperative risk factors of ureteral endometriosis

Evaluation of preoperative risk factors of ureteral endometriosis By Selma Oransay

Endometriosis affects the urinary tract in 1% to 5.5% of the patients, and among them, bladder involvement is 70-85%, while ureteral involvement alone is 9% to 23%.  Ureteral endometriosis is most commonly unilateral, especially on the left side, usually affecting…

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Promising potential research topic: diagnostic biomarkers for endometriosis

Promising potential research topic: diagnostic biomarkers for endometriosis By Nasuhi Engin Aydin

Dr. Toczek and collegues from the Department of Gynecology, Obstetrics and Oncological Gynecology of Medical University of Silesia in Katowice, Poland, have  published a review paper on possible diagnostic aid of cytokines in endometriosis. This review appears in May issue…

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Endometriosis Surgery Improves Sex Life

Endometriosis Surgery Improves Sex Life By Özge Özkaya

Women who underwent laparoscopic resection surgery to treat their deep infiltrating endometriosis had improved sexual quality of life and health-related quality of life according to a new study published in the Journal of Minimally Invasive Gynecology. These findings are important…

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Myeloid-Derived Suppressor Cells are gaining importance in endometriosis

Myeloid-Derived Suppressor Cells are gaining importance in endometriosis By Nasuhi Engin Aydin

Dr. Wertel and associates from Polish academic centers published their sentimental review paper on the role of "Myeloid-Derived Suppressor Cells" in human diseases, in a recent issue of  Cells. Endometriosis, the most common gynecological disease affecting about 10% of women globally,…

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Postoperative infertility management using Endometriosis Fertility Index in endometriotic women

Postoperative infertility management using Endometriosis Fertility Index in endometriotic women By Selma Oransay

"Endometriosis Fertility Index '' score, described by the World Endometriosis Society in 2017, is a robust score and assists to predict the spontaneous pregnancy rate of women with endometriosis, within 3 years after their operation. Its calculation is possible by patient…

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Could There Be a Relationship Between Endometriosis and the "Restless Leg Syndrome"?

Could There Be a Relationship Between Endometriosis and the By Özge Özkaya

Women with endometriosis have a significantly higher prevalence of restless leg syndrome according to a study published in the scientific journal "Frontiers in Endocrinology". This is the first study highlighting such an association between the two conditions. These findings are important…

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Progestin suppression for endometriosis before IVF

Progestin suppression for endometriosis before IVF By Hale Goksever Celik

“Dienogest is a suitable and safe substitute for GnRHa pretreatment in endometriosis patients”, according to the Khalifa et al., from Egypt. Endometriosis is one of the leading reasons for infertility due to decreased oocyte/embryo quality, fertilizability, tubal function, and aberrant endometrial…

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The endless burden: sexual dysfunction and endometriosis

The endless burden: sexual dysfunction and endometriosis By Bahar Yuksel

The relationship between endometriosis and sexual health in women is one of the hottest topics in obstetrics and gynecology practice. There are some previous reports that investigated the effect of endometriosis on the loss of libido, arousal disorder, orgasmic dysfunction,…

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What Happens to Endometriosis Patients After Endometriosis Surgery?

What Happens to Endometriosis Patients After Endometriosis Surgery? By Özge Özkaya

Although few patients with endometriosis who undergo a hysterectomy need repeat surgery, up to 25% of them need minor surgery. Around 20% of patients who undergo conservative surgery with ovarian preservation require additional endometriosis surgery. Up to one in three…

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Endometriosis in intestine! Segmental resection or linear nodulectomy?

Endometriosis in intestine! Segmental resection or linear nodulectomy? By Bahar Yuksel

Intestinal involvement of endometriosis is common, and the incidence was defined between 45-56%. Previous studies investigating the role of surgery in the management of intestinal endometriosis reported improvement of life quality in up to 95% of cases following surgery. However,…

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Optimal management of infertility in endometriosis patients

Optimal management of infertility in endometriosis patients By Hale Goksever Celik

Pelvic pain and infertility are the main symptoms of endometriosis patients. Although the pathophysiological mechanism for infertility is not clearly understood, there are several theories explaining decreased fertility potential in women with endometriosis. Ata and Telek, from Koc and Istanbul Universities…

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The association of chronic endometritis, endometriosis and tubal infertility

The association of chronic endometritis, endometriosis and tubal infertility By Selma Oransay

Holzer et al. from the Department of Gynecologic Endocrinology and Reproductive Medicine of  Medical University of Vienna, Austria, set up apilot prospective cohort study to evaluate the relationship between chronic endometritis, infertility and endometriosis. The results of the study were recently…

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Endometriosis and susceptibility to COVID-19

Endometriosis and susceptibility to COVID-19 By Nasuhi Engin Aydin

Dr. Moazzami and associates from Pars Advanced and Minimally Invasive Medical Manners Research Center, Tehran, Iran have published their results on COVID-19 in endometriosis patients in the medical journal named "BMC’s Women’s Health". COVID-19 is still an emerging critical global health problem…

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A gentle touch on nerves affects dyspareunia

A gentle touch on nerves affects dyspareunia By Bahar Yuksel

Endometriosis is a common disorder among women. Previous studies reported endometriosis-related deterioration of the quality of life. Deep dyspareunia is a common symptom of endometriosis and young patients face dyspareunia twice as much. Surgical treatments are alternative to medical therapies in cases…

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Improvement of the quality of life after surgery for deep infiltrating endometriosis.

Improvement of the quality of life after surgery for deep infiltrating endometriosis. By Selma Oransay

Deeply infiltrating endometriosis is the most severe form among the endometriosis types. The required laparoscopic approach is the appropriate excision of endometriotic foci from pelvis, by consideration of failure and side effects of the medical treatments. The specialist endometriosis centers…

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Problems in the treatment of deep infiltrating endometriosis

Problems in the treatment of deep infiltrating endometriosis By Bahar Yuksel

The Deep Infiltrating Endometriosis (DIE) is very aggressive in nature with infiltrating the whole pelvic, colon, rectum, bladder, ureter, and pelvic wall. D’Alterio and colleagues analyzed the advantages and disadvantages of both medical and surgical therapies for DIE. The authors…

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Postoperative long-term estro-progestin therapy for endometrioma

Postoperative long-term estro-progestin therapy for endometrioma By Selma Oransay

After the removal of ovarian endometriomas, the major concern is the high recurrence rate of symptoms and endometriotic cysts. The estimated recurrence rate of endometriomas is up to 50% at 5 years after surgery. To prevent the recurrence, postoperatively long-term…

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Autophagy, Endometrium and Endometriosis

Autophagy, Endometrium and Endometriosis By Dr. Youngran Park

Autophagy, or autophagocytosis, is a self-digestion process by which cells recycle non-functional proteins to repurpose them. Unwanted cellular parts in cytosolic material are first isolated within double-membrane vesicles called the autophagosome, which subsequently fuses with the acidic lysosome. Autophagy is a survival…

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Immune-mediated conditions and endometriosis in adolescents and adults

Immune-mediated conditions and endometriosis in adolescents and adults By Hale Goksever Celik

The most common presenting complaints of endometriosis are mainly pelvic pain and infertility, commonly in relation to the menstrual period. Affected women demand therapy for these symptoms. Immunologic diseases such as autoimmune and/or inflammatory diseases, allergies, asthma, previous mononucleosis infection,…

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Testosterone levels effect embryo implantation rates in patients with endometriosis

Testosterone levels effect embryo implantation rates in patients with endometriosis By Bahar Yuksel

Endometriosis is associated with infertility either causing poor oocyte and embryo qualities or poor endometrial receptivity. The effect of androgen levels on IVF outcomes has been described earlier, but the present study conducted by Ling Huang et assocates is the…

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Fertilization rate and pregnancy outcome in IVF cycles of endometriosis.

Fertilization rate and pregnancy outcome in IVF cycles of endometriosis. By Selma Oransay

Endometriosis affects the pelvic cavity, uterus, ovaries and causes impaired fertility as a result. The chronic inflammatory nature of this disease negatively impacts the oocyte quality, maturation, and fertilization. Obviously, fewer oocytes can be harvested in the IVF cycles of…

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Adenomyosis: accuracy of the diagnostic methods and the synchronism with deep infiltrating endometriosis

Adenomyosis: accuracy of the diagnostic methods and the synchronism with deep infiltrating endometriosis By Nasuhi Engin Aydin

Dr. Alborzi and associates from Shiraz University of Medical Sciences, Iran, have published their comprehensive retrospective research conducted on 3725 patients with clinical symptoms of endometriosis over a period of 3 years, in "Reproductive Sciences" medical journal.  A relationship between…

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Can we measure the severity of endometriosis?

Can we measure the severity of endometriosis? By Dr. Youngran Park

Endometriosis is an enigmatic disease associated with serious morbidity and change in the quality of life. Unfortunately, there is no specific test for the diagnosis of endometriosis. While many markers were evaluated in many research studies for the noninvasive diagnosis…

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Postoperative treatment and pregnancy points to decreased recurrence risk for ovarian endometriosis

Postoperative treatment and pregnancy points to decreased recurrence risk for ovarian endometriosis By Hale Goksever Celik

Endometriosis is a disease most frequently diagnosed in women of reproductive age and negatively affects the quality of life. The most common localization for endometriosis is ovaries with a prevalence of 17-44%. Laparoscopic ovarian cystectomy performed as excision or ablation…

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Endometriosis, ART, fertility preservation

Endometriosis, ART, fertility preservation By Selma Oransay

This review entitled "The impact of endometriosis on the outcome of assisted reproductive techniques: role of fertility preservation" was written by Necula et al. from Gynecology and Obstetrics Unit, Biel, Switzerland, and recently published in the journal "Hormone, Molecular Biology and Clinical…

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Tubo-ovarian abscess and endometriosis

Tubo-ovarian abscess and endometriosis By Bahar Yuksel

A tubo-ovarian abscess is the result of pelvic inflammatory disease in women and the previous reports demonstrated that almost one of the third women with a pelvic inflammatory disease had a tubo-ovarian abscess. The main treatment modalities for tubo-ovarian abscess…

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Pain Sensitization and What Should Be Done About it?

Pain Sensitization and What Should Be Done About it? By Özge Özkaya

Pain sensitization and lumbopelvic impairments are common among women with endometriosis, especially if they have advanced stage disease. This is according to a study by researchers in Spain that was published in the scientific journal "Pain Medicine". The finding underscores the…

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Erastin, Ferroptosis and Endometriosis

Erastin, Ferroptosis and Endometriosis By Dr. Youngran Park

Iron overload has been linked to endometriosis. There are abundant free iron and high oxidation in ectopic lesions, probably due to retrograde menstruation. Interestingly, iron overload in endometriosis activates NF-kB signaling and results in proinflammatory communication. More clear pieces of…

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Cancer, is that a real risk?

Cancer, is that a real risk? By Yu Yu

Endometriosis is non-malignant but shares some similar features with cancer, such as the occurrence of local and distant foci, the ability to resist cell death, and the ability to invade other tissues, causing damage to the organs. Endometriosis also generates…

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Controlled use of bipolar cauterization as an alternative to endometrioma cystectomy

Controlled use of bipolar cauterization as an alternative to endometrioma cystectomy By Hale Goksever Celik

The main symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Ablation or coagulation of the cyst wall following laparoscopic drainage of endometrioma may be an alternative treatment for patients with pregnancy intention. Carbon dioxide, laser, and plasma energy…

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Perineal Endometriosis, How Soon Does it Return After Surgery?

Perineal Endometriosis, How Soon Does it Return After Surgery? By Özge Özkaya

The higher the body mass index (BMI) of a woman during delivery and within one month after delivery, the quicker the symptoms of perineal endometriosis return. This is according to a recent study that appeared in the World Journal of…

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The influence of endometrioma and surgery on ovarian reserve

The influence of endometrioma and surgery on ovarian reserve By Dr. Youngran Park

Women with endometriosis and endometrioma, often have subfertility. These patients present considerable problems for the evaluation of ovarian reserve. One of the well-known ovarian reserve biomarkers is anti-Müllerian hormone (AMH) levels. So far, it was known that the reduction of…

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Selected Blood Inflammatory Biomarkers May Help Identify Endometriosis

Selected Blood Inflammatory Biomarkers May Help Identify Endometriosis By Özge Özkaya

Levels of inflammatory biomarkers in the blood differ between women with endometriosis and those without the disease. Levels of some biomarkers also differ according to the stage of endometriosis. This is according to a new study by Polish scientists published…

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“Advanced gynecological ultrasound” for women with suspected endometriosis

“Advanced gynecological ultrasound” for women with suspected endometriosis By Hale Goksever Celik

Different clinical forms of endometriosis such as superficial endometriosis, endometrioma, and deep infiltrating endometriosis are present. Although no specific diagnostic tool is available for endometriosis, clinical findings, physical examination and imaging including transvaginal ultrasound and MRI are helpful to determine…

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Endometriosis and possible cardiovascular outcomes

Endometriosis and possible cardiovascular outcomes By Selma Oransay

A retrospective population-based cohort study from the Institute of Applied Health Research, University of Birmingham, Birmingham, the UK, investigated the long-term cardiovascular outcomes of women with endometriosis. The study included 279,759 women in total, 20,1% (>56.000) were patients with surgically…

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The effects of endometriosis on life satisfaction.

The effects of endometriosis on life satisfaction. By Bahar Yuksel

Endometriosis is well-known for its debilitating effects on women suffering from it. In the review conducted by Masoumeh Namazi et al, the authors have collected studies searching for the wellbeing of women with endometriosis. They have analyzed 46 studies that…

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Endometrial receptivity after the removal of ovarian endometriotic cysts

Endometrial receptivity after the removal of ovarian endometriotic cysts By Nasuhi Engin Aydin

Mikhaleva and associates from the "Russian Research Institute of Human Morphology" published their results in “Reproductive Sciences” yielding their novel morphological findings of eutopic endometria in patients following surgical excision of endometriotic ovarian cysts. Current therapeutic measures are targeting to…

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Managing the physical and emotional effects of endometriosis

Managing the physical and emotional effects of endometriosis By Hale Goksever Celik

Endometriosis is known to affect 5-10% of the general population, but some women are underdiagnosed due to physical and psychological disability. Due to the symptoms including dysmenorrhea, dyspareunia, chronic pelvic pain and infertility, endometriosis has a negative effect on the quality…

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Environmental to occupational exposure, and possible risk factors for endometriosis.

Environmental to occupational exposure, and possible risk factors for endometriosis. By Selma Oransay

Many objects in daily use are made of plasticizing agents. Studies suggest that chronic exposure to these agents are toxic to reproductive organs and cause metabolic disorders. For example, diethyl phthalate is still in use in cosmetic products.  Caporossi et…

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DNA damage response in eutopic endometria of endometriosis patients

DNA damage response in eutopic endometria of endometriosis patients By Dr. Youngran Park

The DNA damage response (DDR) is a network of cellular pathways that sense, signal, and repair the lesions occurring in DNA. Surveillance proteins that monitor DNA integrity activate the DNA repair pathways in response to DNA damage and try to prevent the generation of potentially deleterious mutations. Endometriosis is an estrogen-dependent…

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Impaired fertility potential in endometriosis patients

Impaired fertility potential in endometriosis patients By Hale Goksever Celik

Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis and sperm movements. Garcia-Fernandez and García-Velasco, from Edinburgh, UK and Madrid, Spain, published a mini-review titled “Endometriosis and Reproduction: What We Have…

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Oxygen deprivation (hypoxia) has a critical role in the pathogenesis and progression of endometriosis

Oxygen deprivation (hypoxia) has a critical role in the pathogenesis and progression of endometriosis By Nasuhi Engin Aydin

Dr. Wan-Ning Li and associates from academic institutions from Taiwan have published their review paper on the role of hypoxia and possible therapeutic outcomes in the medical journal named "Reproduction" recently.  Endometriosis is an important ailment with huge medical and social…

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Endometriosis and the risk of Systemic lupus Erythematosus: A report from Taiwan

Endometriosis and the risk of Systemic lupus Erythematosus: A report from Taiwan By Selma Oransay

Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage that affects mostly women, with an M:F ratio of 1:9. Recent evidence has also shown that endometriosis is…

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The incidence of endometriosis and pelvic pain in transgender man

The incidence of endometriosis and pelvic pain in transgender man By Bahar Yuksel

Transgender operations are quite common all around the world and hysterectomies are performed almost 1 in 5 of this population. The studies conducted until now mostly evaluated operative and postoperative outcomes, but the present research also questioned the preoperative symptoms and…

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Nanomedicines for Endometriosis

Nanomedicines for Endometriosis By Dr. Youngran Park

Scientific research on nanoparticles is intense as they have many potential applications in medicine. Nanomaterials have been widely explored for imaging and treatment of various diseases, especially cancer, over the recent twenty years.  The absence of non-invasive diagnostic tests and…

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The improvement of fertility rate and symptoms of superficial endometriosis following laparoscopic peritoneal stripping

The improvement of fertility rate and symptoms of superficial endometriosis following laparoscopic peritoneal stripping By Selma Oransay

Pain, in the form of diverse entities, including dyspareunia, dysuria, dyschezia, is the main symptom of endometriosis patients. The severity of pain is independent of the extent and the location of the disease, and generally causes a negative impact on…

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Vitamin D supplementation, endometriosis symptoms and metabolic profiles

Vitamin D supplementation, endometriosis symptoms and metabolic profiles By Hale Goksever Celik

Patients with endometriosis suffer from dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. These women are also at higher risk for ovarian and breast cancer, cardiovascular events, and metabolic abnormalities. Several medical and surgical alternatives have been recommended to these patients…

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Cancer risk Evaluation in Korean Endometriosis Cohort

Cancer risk Evaluation in Korean Endometriosis Cohort By Bahar Yuksel

The relationship between endometriosis and cancer has always been challenging. The previous studies revealed an increased risk in endometriosis-associated ovarian cancers regarding the alterations in cancerogenic genes or by the effect of iron and hem coming with retrograde menstruation and…

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A comparison of symptomatology and histopathologic features in surgically resected colorectal endometriosis

A comparison of symptomatology and histopathologic features in surgically resected colorectal endometriosis By Nasuhi Engin Aydin

Dr. Tschan and associates from Feldrich Academic Teaching Hospital, Austria published their retrospective research on patients requiring colorectal surgical resection for endometriosis in European Journal of Medical Research. Bowel endometriosis requiring colorectal surgical resection causes important morbidity. The rectum and…

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Antioxidant therapy for the endometriosis pain

Antioxidant therapy for the endometriosis pain By Selma Oransay

Ts the protective defense mechanism of cells, hence the destruction of balance between oxidants and antioxidants in our body is called "redox imbalance".  The major oxidants are reactive oxygen species (ROS) that are involved in multiple cellular processes by physiologically…

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Ovarian, breast and endometrial cancer coexisting with endometriosis.

Ovarian, breast and endometrial cancer coexisting with endometriosis. By Selma Oransay

The invasive nature of endometriosis results in calling the disease " benign cancer". The transformation of endometriosis to malignancy is rare, but when compared to the general population, the relative risk of developing ovarian cancer is 4.2 times greater especially…

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Self-management and the quality of life in women with endometriosis

Self-management and the quality of life in women with endometriosis By Hale Goksever Celik

Endometriosis symptoms can range from mild to severe. The most common presenting complaints are mainly pelvic pain and infertility. There is no doubt that the physical and mental quality of life of these women is adversely affected. There are several studies…

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The role of hormonal treatment after endometriosis surgery

The role of hormonal treatment after endometriosis surgery By Bahar Yuksel

Postoperative hormonal suppression after endometriosis surgery still does not have a uniform approach. The meta-analysis study conducted by Zakhari et al. aimed to find a significant answer regarding this burden. They analyzed the database systems including MEDLINE, Embase, Cochrane CENTRAL,…

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The association between body size and endometriosis

The association between body size and endometriosis By Irem Onur

Until today there have been few studies investigating body size in childhood and adolescence in women with endometriosis. A new study published recently in the journal Acta Obstetricia et Gynecologica Scandinavica provides further evidence of the associations between endometriosis, body…

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"Speckle sign": a novel transvaginal ultrasound finding for posterior compartment endometriosis

By Nasuhi Engin Aydin

Dr. Balcacer and associates from three medical institutions located in the USA report the results of their retrospective study on deep infiltrating endometriosis utilizing transvaginal ultrasound examination and the proposed  “speckle sign” in the "Journal of Ultrasound Medicine". Pelvic ultrasound…

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Oxidative stress, reactive products, detoxification, endometriosis and pain

Oxidative stress, reactive products, detoxification, endometriosis and pain  By Ellen Tumimbang

Oxidative stress is one factor known to be involved in the pathogenesis, progression, and establishment of endometriosis in women.   During oxidative stress, excess reactive oxygen species as a secondary by-product of lipid peroxidation and reactive aldehyde including 4- hydroxynonenal…

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Live Birth Rate in Women Who Underwent Fresh Embryo Transfer Using Freshly Retrieved Donor Oocytes

Live Birth Rate in Women Who Underwent Fresh Embryo Transfer Using Freshly Retrieved Donor Oocytes By Hale Goksever Celik

One of the important clinical findings in women with endometriosis is reproductive problems. Infertility can be encountered in up to 50% of women with endometriosis and up to 50% of women with infertility can be diagnosed with endometriosis. Several pathophysiologic…

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What is the cause of Dienogest-resistance in patients with endometrioma?

 What is the cause of Dienogest-resistance in patients with endometrioma? By Selma Oransay

Endometriosis may cause infertility in women, leading to adhesions in the pelvis, besides affecting the ovaries. Clinicians concern about the child-bearing desire of their patients when treating them surgically or with hormonal therapy. Dienogest (DNG) is a kind of progestin,…

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Time for noninvasive serum markers for endometriosis diagnosis

Time for noninvasive serum markers for endometriosis diagnosis By Nasuhi Engin Aydin

Dr. Onur Guralp and associates from Germany and Turkey published their results on serum markers predicting endometriosis in the "Journal of Obstetrics and Gynaecology".   Still, in 21st-century medicine, doctors can not diagnose endometriosis using biochemical serum markers. Proposed serum markers…

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Analysis of women with endometriosis-related pain before the multidisciplinary endometriosis care management

Analysis of women with endometriosis-related pain before the multidisciplinary endometriosis care management By Irem Onur

Endometriosis patients are generally treated by a single provider and they frequently report dissatisfaction with care. To decrease diagnostic delays, improve pain management, and promote patient satisfaction, multidisciplinary endometriosis centers emerged. But, baseline data assessing the efficacy of the multidisciplinary…

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High-dose progestin intake and sexual functions in endometriosis patients

High-dose progestin intake and sexual functions in endometriosis patients By Selma Oransay

Dr. Oppenheimer et al. from the Department of Reproductive Medicine and Fertility Preservation of Antoine Beclere University Hospital, Clamart, France, recently published this bi-center observational prospective study in "Acta Obstetrica et Gynecologica Scandinavica". The study was designed to put forth…

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Endometriosis, Fatigue and Productivity

 Endometriosis, Fatigue and Productivity By Ellen Tumimbang

Fatigue is one of the prominent and distressing symptoms of endometriosis-associated with insomnia, depression, pain, occupational stress, and reduced health-related quality of life. Endometriosis-related fatigue causes significant impairments in workplace productivity and daily activities of women with endometriosis. Loss of…

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Postoperative pregnancy rate in infertile women with deep infiltrating endometriosis

 Postoperative pregnancy rate in infertile women with deep infiltrating endometriosis By Hale Goksever Celik

Deep infiltrating endometriosis (DIE) is fibrous/muscular infiltration of organs and anatomical structures containing endometrial tissue below the peritoneum regardless of the depth of infiltration. Another definition describes DIE as infiltration of the peritoneum by endometriotic lesions deeper than 5 mm. Pain,…

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Deep endometriosis treatment options based on the patient's decision

 Deep endometriosis treatment options based on the patient's decision By Selma Oransay

Deep endometriosis, defined as endometriotic lesions penetrating deeper than 5 mm into the peritoneum comprise approximately 20% of all endometriosis cases. This invasive disease causes a significant reduction in the quality of life, social participation, and sexual health of affected…

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KEYNOTE: Excision Without Mutilation: It’s Possible! -  Arnaud Wattiez, MD

KEYNOTE: Excision Without Mutilation: It’s Possible! -  Arnaud Wattiez, MD By Özge Özkaya

In his keynote lecture, Dr. Wattiez talks about the pros and cons of endometriosis surgery and the importance of tailoring endometriosis surgery to individual patients.  “Endometriosis is a disease that degrades patient’s wellbeing," Dr. Wattiez says and gives some examples…

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Exploring the Role of Neuropathy in Re-Operative Endometriosis - Marc Possover, MD, PhD

Exploring the Role of Neuropathy in Re-Operative Endometriosis - Marc Possover, MD, PhD By Özge Özkaya

Prof. Possover starts his presentation by summarizing the possible cause of pelvic neuropathy following endometriosis surgery. Pelvic neuropathy is the damage or dysfunction of the pelvic nerve. Prof. Possover explained that this could either be due to incomplete surgery, disease…

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Operative techniques for Deep Endometriosis Surgery - Shaheen Khazali, MD

Operative techniques for Deep Endometriosis Surgery - Shaheen Khazali, MD By Özge Özkaya

In this presentation, Dr. Shaheen Khazali, an endometriosis surgeon specialized in gastrointestinal and urinary tract endometriosis excision and in neuropelveology, talks about the general principles and some techniques for endometriosis surgery focusing on rectovaginal endometriosis. He also describes the "ten…

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Laparoscopic Approach to Rectus Muscle Endometriosis and Inguinal Endometriosis - Ted Lee, MD

Laparoscopic Approach to Rectus Muscle Endometriosis and Inguinal Endometriosis - Ted Lee, MD By Selma Oransay

Rectus muscle endometriosis and inguinal endometriosis are two rare types of endometriosis. Operation room videos of several patients with different rectus muscle endometriosis and inguinal endometriosis are shared during the presentation of Dr. Lee to clarify the methods of the…

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Separation of epithelia and stroma components in endometriosis lesions yields remarkable molecular points - Ie-Ming Shih, MD, Ph.D.

Separation of epithelia and stroma components in endometriosis lesions yields remarkable molecular points - Ie-Ming Shih, MD, Ph.D. By Nasuhi Engin Aydin

The pathologies of adenomyosis and endometriosis are unique among non-malignant gynecological diseases and provide fertile research topics. Ectopic endometrial tissues may have distinct molecular changes distinct from eutopic endometria despite having similar morphology. In this regard, there are intriguing suggestions as…

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Exploring Pelvic Pain: Deep to Ischial Spine Including Pre-Sacral Roots - A. Taner Usta, MD

Exploring Pelvic Pain: Deep to Ischial Spine Including Pre-Sacral Roots - A. Taner Usta, MD By Irem Onur

Chronic pelvic pain is defined as pain in the pelvic area that lasts for 6 months or longer and results in functional or psychological disability or requires intervention and treatment by the American College of Obstetrics and Gynecologists. There are…

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Why Persistent or Recurrent Endometriosis Happens? - Dan Martin, MD

Why Persistent or Recurrent Endometriosis Happens? - Dan Martin, MD By Ellen Tumimbang

The objectives of Dr. Martin in this presentation are to understand the difficulties in recognition of deep and hidden endometriosis, difficulties in recognition of small lesions of micron size, and differentiate the look-alike lesions of endometriosis. He addressed overcoming these…

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Role of Prophylactic Oophorectomy in Endometriosis Patients with Ovarian Cancer History in the family - Farr Nezhat, MD

Role of Prophylactic Oophorectomy in Endometriosis Patients with Ovarian Cancer History in the family - Farr Nezhat, MD By Özge Özkaya

Dr. Nezhat starts his presentation by outlining his objectives, which are to review the basics of cancer genetics, give an overview about endometriosis and ovarian cancer, discuss the pathogenesis of malignant transformation of endometriosis, and talk about the clinical implications…

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Further Evidence that endometriosis is related to tubal or ovarian cancer - Togas Tulandi, MD

Further Evidence that endometriosis is related to tubal or ovarian cancer - Togas Tulandi, MD By Selma Oransay

Most authors suggest an association of endometriosis mainly with clear cell, low-grade serous, and endometrioid ovarian cancer.  But in two large cohort studies, no correlation between them is reported (Olson et al. 2002 and Tseng et al. 2019) Dr. Tulandi…

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Insoluble Dilemma of Adenomyosis: Diagnosis, Management, and Treatment  - Errico Zupi, MD

Insoluble Dilemma of Adenomyosis: Diagnosis, Management, and Treatment  - Errico Zupi, MD By Selma Oransay

The prevalence of adenomyosis has been reported to range from 1% to 70% in different studies. This large range can be explained by the lack of standard diagnostic criteria by imaging modalities or pathological analyses. Sixty-five% of the women with adenomyosis…

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It is time for redefining endometriosis with our contemporary scientific knowledge - Philippe Koninckx, MD, Ph.D.

It is time for redefining endometriosis with our contemporary scientific knowledge -  Philippe Koninckx, MD, Ph.D. By Nasuhi Engin Aydin

Endometriosis defined as endometrium-like tissue outside the uterus has a poorly understood natural history. It is a heterogeneous disease having genetic-epigenetic features with many biochemical changes in the lesions. The Sampson hypothesis of implanted endometrial cells following retrograde menstruation is not…

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Urological Challenges in Endometriosis Surgery - Guenter Noe, MD

Urological Challenges in Endometriosis Surgery - Guenter Noe, MD By Özge Özkaya

In this presentation, Dr. Guenter Noé, Head of Department of Rheilandklinikum Dormagen in Germany talks about endometriosis affecting the urinary tract. Dr. Noé starts by describing the different parts of the urinary tract that can be affected by endometriosis including…

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Implantation failure in endometriosis patients - Jovana Lekovich, MD., PhD.

Implantation failure in endometriosis patients - Jovana Lekovich, MD., PhD. By Hale Goksever Celik

Endometriosis is one of the leading reasons for infertility due to decreased oocyte/embryo quality, fertilization ability, tubal function, and aberrant endometrial receptivity. Whether this failure is caused by oocyte/embryo or eutopic endometrium is one of the investigated topics in endometriosis…

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Fixing holes: prevention and treatment of complications - Jon Einarsson, MD, MPH

Fixing holes: prevention and treatment of complications - Jon Einarsson, MD, MPH By Selma Oransay

Dr. Einarsson shared his operating room video screens during his speech for discussing four major complications (ureter, bladder,  bowel, and vascular) of endometriosis surgery and the ways to repair them. Fixing the ureter damage: Endometriotic nodules may settle on the tract…

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Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD

Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD By Selma Oransay

The removal of endometrioma may affect ovarian reserve because healthy follicles near endometrioma could also be excised during this procedure. Another concern about the ovarian reserve is that it may be already low before the surgery. Anti Mullerian Hormone (AMH)…

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In vitro fertilization protocols in endometriosis patients - Pinar Kodaman, MD., PhD.

In vitro fertilization protocols in endometriosis patients - Pinar Kodaman, MD., PhD. By Hale Goksever Celik

Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis, and sperm movements. Even though the disease stage and presence of endometrioma is negatively correlated with infertility, it is unpredictable which women…

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Could Cosmetics and Personal Care Products Increase the Risk of Endometriosis?

Could Cosmetics and Personal Care Products Increase the Risk of Endometriosis? By Özge Özkaya

The use of cosmetics and personal care products may be increasing the risk of endometriosis according to a study by Spanish researchers that was published in the journal "Environmental Research". This finding suggests that restricting the use of these products may…

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Endometriosis and the sexual relations of the couples

Endometriosis and  the sexual relations of the couples By Selma Oransay

From the viewpoint of endometriotic women, the pain during the penetration is not the only complaint. They also have growing depression and anxiety leading to difficulties with their social and sexual relationship, work, and study. The emotional impact of sub-infertility,…

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A Possible genetic target for endometriosis treatment

A Possible genetic target for endometriosis treatment By Dr. Youngran Park

Mutations in the chromosome remodeling complex SWI/SNF subunit ARID1A were first identified in ovarian clear-cell carcinoma and ovarian endometrioid carcinoma, two endometriosis-associated epithelial ovarian cancer subtypes. ARID1A gene mutations are also observed in deep ovarian and deep infiltrating endometriosis, atypical endometrial…

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Endometriosis involving the Sacral Plexus and Sciatic Nerve

Endometriosis involving the Sacral Plexus and Sciatic Nerve By Irem Onur

Endometriosis rarely involves the sacral and sciatic nerves. A retrospective analysis led by Rouen University Hospital, France and Aarhus University Hospital, Denmark, published in the Journal of Minimally Invasive Gynecology, has evaluated preoperative complaints, intraoperative findings, surgical procedures, and postoperative…

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Endometrioma size and anti-Müllerian hormone levels

Endometrioma size and anti-Müllerian hormone levels By Hale Goksever Celik

Endometriotic lesions are encountered in different locations in the pelvic cavity, including but not limited to the ovaries, the pouch of Douglas, the ureters, the bladder, and the bowel. Cystic endometriosis lesions located in the ovary are called "endometrioma". Endometriomas have…

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Does hysterectomy bring a total relief in patients with endometriosis?

Does hysterectomy bring a total relief in patients with endometriosis? By Bahar Yuksel

There is a common belief that hysterectomy is the last option to relieve the pain in patients with endometriosis by stopping the production of menstrual material. The study entitled "Impact of hysterectomy on analgesic, psychoactive and neuroactive drug use in…

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Pelvic MRI, Endometriosis and Radiologist

Pelvic MRI, Endometriosis and Radiologist By Murat Osman

Endometriosis is a condition whereby ectopic endometrial cells implant themselves onto other structures within the body. Depending on where these lesions are, their size, and if they cause symptoms, surgical intervention may be warranted. Although the gold standard for diagnosing…

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How to unveil the discrepancy regarding the effect of chemicals on the etiology of endometriosis

How to unveil the discrepancy regarding the effect of chemicals on the etiology of endometriosis By Nasuhi Engin Aydin

Kristen Upson from Michigan State University published a review article evaluating research papers on environmental factors effective in endometriosis from an epidemiological perspective in "Current Epidemiology Reports". Endometriosis is a multifactorial disease with anatomical, hormonal, immunological, estrogenic, genetic, epigenetic, and…

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Endometriosis and chronic opioid use

Endometriosis and chronic opioid use By Selma Oransay

The members of the American College of Obstetricians and Gynecologists have declared that gynecologists prescribe opioids after laparoscopic hysterectomy, or for relieving endometriosis pain, although guidelines are not available for when or how to use opioids for the treatment of endometriosis-associated…

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Adolescent endometriosis: Diagnostic clues?

Adolescent endometriosis: Diagnostic clues? By Irem Onur

The rates of dysmenorrhea, dyspareunia, and heavy menstrual bleeding in adolescents showing endometriosis signs on ultrasound are significantly higher compared to those without. This is according to a retrospective observational study recently published in the journal "Fertility and Sterility". The…

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Reduced risk of "small for gestational age baby" following frozen embryo transfer in endometriosis patients

Reduced risk of By Hale Goksever Celik

Infertility is encountered frequently in patients with endometriosis. These women could be managed using assisted reproductive technology (ART) including in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) to achieve pregnancy. However, some adverse obstetric and perinatal outcomes are experienced more…

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Endometrial fluid analysis as a new diagnostic test for endometriosis diagnosis

Endometrial fluid analysis as a new diagnostic test for endometriosis diagnosis By Bahar Yuksel

There is still a huge demand for finding a minimally invasive diagnostic test for endometriosis and yet none has been defined properly. The present study which was conducted in Cleveland Clinic by Natalia C. Llarena et al between March 2017…

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Comparison of diagnostic accuracy of imaging modalities for the deep infiltrating endometriosis

Comparison of diagnostic accuracy of imaging modalities for the deep infiltrating endometriosis By Selma Oransay

The treatment of deeply infiltrated endometriosis (DIE) is usually personalized and the potential success for the available therapeutical options is dependent on early and accurate diagnosis. Laparoscopy is the gold standard for the diagnosis of DIE. Other non-invasive diagnostic methods…

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Endometriosis and adenomyosis could be the “sides of the same coin”.

Endometriosis and adenomyosis could be the “sides of the same coin”. By Nasuhi Engin Aydin

The two common gynecological disorders, namely adenomyosis, and endometriosis are not settled yet, whether they are representing two different entities or different phenotypes of the same ailment. Dr. Maruyama and colleagues from Nara, Japan searched PubMed and Google Scholar electronic…

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Endometriosis and Natural Killer Cell Immunity

Endometriosis and Natural Killer Cell Immunity By Dr. Youngran Park

It is known that approximately 25 to 50% of infertile women have endometriosis, and 30% to 50% of the women with endometriosis have infertility and recurrent pregnancy loss. Previous studies have shown that women suffering endometriosis have abnormal NK cell…

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Magnetic resonance imaging classification for the management of deep pelvic endometriosis

Magnetic resonance imaging classification for the management of deep pelvic endometriosis By Irem Onur

A new study published in the journal "Human Reproduction" reported that operating time, hospital stay, and postoperative complications in patients who underwent surgery for deep endometriosis can be predicted by the MRI. This result may be useful for clinicians to…

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Combination of noninvasive biomarkers in the identification of endometriosis

Combination of noninvasive biomarkers in the identification of endometriosis By Timur Seckin

The combined measurement of urine enolase, serum CA125, and CA19-9 may be an accurate test for the prediction and detection of endometriosis. This is according to a study published in the journal BioMedical Research International. The gold standard for the…

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Patients' opinion about surgical treatment of endometriosis

Patients' opinion about surgical treatment of endometriosis By Selma Oransay

Delayed diagnosis and management of endometriosis and chronic pelvic pain is a major problem in gynecologic practice. Alternatively, providers may feel reluctant to perform surgery although they are aware of treatment options and surgical timing. One possible reason for this…

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Segmental bowel resection could be predicted using MRI in patients with rectal endometriosis

Segmental bowel resection could be predicted using MRI in patients with rectal endometriosis By Hale Goksever Celik

The rectum and recto-sigmoid junction are the preferential localisations of bowel endometriosis. The three main surgical approaches are shaving, disc excision, and segmental resection. It is very important to decide the most appropriate surgical method preoperatively and to plan accordingly. …

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Can a grape ingredient, resveratrol, be the promised warrior to defeat endometriosis?

Can a grape ingredient, resveratrol, be the promised warrior to defeat endometriosis? By Bahar Yuksel

Endometriosis is a chronic estrogen-dependent disorder and has a known relationship with angiogenesis, inflammation, and oxidative stress. Resveratrol is a part of a "polyphenol" compound which are thought to act like antioxidants, protects the body against damage. This compound is normally…

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Dyspareunia and Endometriosis

Dyspareunia and Endometriosis By Irem Onur

Women experience severe pain during intercourse related to endometriosis and this has a significant negative impact on the lives of women. This is according to an American study published in the "Journal of Pain Research". The study included 638 endometriosis…

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Bad bad lipid go away!

Bad bad lipid go away! By Yu Yu

Much like the progression of endometriosis, accumulating evidence suggests that systemic chronic inflammation and oxidative stress can contribute to atherosclerosis. The excess low-density lipoprotein increases inflammatory processes in the arteries, which may result in atherosclerosis. Previous studies have shown that…

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Indocyanine green in endometriosis surgery

Indocyanine green in endometriosis surgery By Selma Oransay

Recently, indocyanine green is well studied and used safely in real-time perfusion to organs or tissues, after taking into consideration its binding capacity to the plasma proteins. The usefulness and the effectiveness of near-infrared camera guided indocyanine green is proved with…

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Osteopontin and Endometriosis

Osteopontin and Endometriosis By Dr. Youngran Park

Although characterized as a benign disease, some properties of endometriosis mimic malignant tissues such as proliferation, cell invasion, and metastasis. Osteopontin, also called secreted phosphoprotein 1, is one of the important molecular targets in cancer progression and metastasis. Osteopontin has been…

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It is time for non-invasive tests for peritoneal endometriosis diagnosis

It is time for non-invasive tests for peritoneal endometriosis diagnosis By Nasuhi Engin Aydin

Maria Szubert with colleagues from Lodz Medical University, Poland, investigated the possibility of potential diagnostic biomarkers in the eutopic endometrial tissue from peritoneal endometriosis patients and published their results in the "Journal of Gynecology Obstetrics and Human Reproduction". Currently, diagnostic…

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Psychometric properties of Endometriosis Health survey-Swedish version

Psychometric properties of Endometriosis Health survey-Swedish version By Hale Goksever Celik

Endometriosis is a chronic estrogen-dependent disease resulting in a broad spectrum of symptoms and signs including dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Additionally, gastrointestinal and urinary systems may be affected by this disease. All of these clinical findings impair…

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Fallopian tube endometriosis

Fallopian tube endometriosis By Bahar Yuksel

Endometriosis affects various tissues including pelvic and extra-pelvic organs. Fallopian tube endometriosis is not a widely studied topic in endometriosis, hence the real incidence is unknown as not all studies evaluate microscopically diagnosed Fallopian tube endometriosis. In the retrospective database…

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Non-coding RNAs and Endometriosis

Non-coding RNAs and Endometriosis By Ellen Tumimbang

Non-coding RNAs may have a fundamental role in the development of endometriosis. Non-coding transcripts have regulatory roles in the expression of protein-coding genes, thus regulate several signaling pathways. Based on their length, these non-coding RNAs are classified into two main classes:…

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Body mass index, the incidence of endometriosis and the severity of dysmenorrhoea

Body mass index, the incidence of endometriosis and the severity of dysmenorrhoea By Timur Seckin

According to a case-control study conducted by researchers from China, there is no association between body mass index (BMI) and the incidence of endometriosis. This finding contrasts with the conventional knowledge that low BMI is a risk factor for endometriosis.…

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An animal model of endometriosis reveals stress related disturbed vitamin D - vitamin D receptor axis

An animal model of endometriosis reveals stress related disturbed vitamin D - vitamin D receptor axis By Nasuhi Engin Aydin

Lopez and colleagues from academic institutions of Puerto Rico published their experimental endometriosis findings on female rats regarding the effect of stress on vitamin D-vitamin D receptor systems and recently published their findings in "Reproductive Sciences". The group previously showed…

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The peculiarity of adolescent endometriosis

The peculiarity of adolescent endometriosis By Selma Oransay

Recent studies showed the prevalence of endometriosis in adolescents with chronic cyclic or acyclic pelvic pain is about 60-70%. Moreover, all stages of endometriosis, including deeply infiltrating endometriosis can be found in this population. Gubbels et al. from the Department…

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The intensity of pelvic pain is higher in endometriosis patients

The intensity of pelvic pain is higher in endometriosis patients By Irem Onur

Silva  J.B. et al., researchers from Brazil, conducted a case-control study to determine the intensity of clinical pain, the average body composition, and the anthropometric markers including the body mass index, the perimeters (waist, abdomen, hip), and the percentage of…

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The more than expected prevalence of endometriosis in patients with Mullerian abnormalities

The more than expected prevalence of endometriosis in patients with Mullerian abnormalities By Bahar Yuksel

Congenital müllerian anomalies resulting in a spectrum of uterine abnormalities are caused by the abnormal embryologic fusion of the müllerian ducts to form a normal uterine cavity.  They are often unrecognized because they are usually asymptomatic. The presence of a uterine…

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Depression and anxiety levels in "in vitro fertilization" patients with endometriosis

Depression and anxiety levels in By Hale Goksever Celik

Endometriosis is a reproductive-aged and estrogen-dependent disease. The most common symptoms of this disease are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility affecting the quality of life in several aspects mainly the psychological domain. In the literature, there are many studies…

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Endometriosis-related obstetrical complications and their outcome

Endometriosis-related obstetrical complications and their outcome By Selma Oransay

Borisova et al. from the Department of Gynecology and Obstetrics of Peoples' Friendship University, Moskow, Russia, and her colleagues from the Center of Perinatal and Reproductive Medicine of University Perugia, Italy, recently published a review of the literature data about…

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Time for reassessment : Laparoscopic surgery and bowel endometriosis

Time for reassessment : Laparoscopic surgery and bowel endometriosis By Nasuhi Engin Aydin

Ferrero and associates from medical centers of Verona and Genoa, Italy, made a comprehensive review covering all aspects of the surgical approach to bowel endometriosis, published their results in "Best Practice & Research Clinical Obstetrics and Gynaecology". Bowel endometriosis is the…

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Cellular communications: Exosomes in Endometriosis

Cellular communications: Exosomes in Endometriosis By Dr. Youngran Park

Exosomes have been reported as cell-to-cell communicators, transfer many molecules such as miRNAs, RNAs, and proteins, and their alteration may cause many disease processes, including endometriosis. Considering the role of exosomes and their cargos in a cell to cell communication as important…

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Predictors of voiding dysfunction after surgery for deep endometriosis

Predictors of voiding dysfunction after surgery for deep endometriosis By Selma Oransay

While surgery for deep endometriosis provides relief and improves the quality of life in symptomatic patients for whom medical therapy has limited effect, it may also create postoperative lower urinary tract dysfunction. Moreover, postoperative voiding dysfunction could affect the quality…

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Sleep Quality, Lifestyle Factors and Endometriosis

Sleep Quality, Lifestyle Factors and Endometriosis By Hale Goksever Celik

Endometriosis does not only affect the patients by dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. An important issue in these patients, like other chronic diseases, is sleep quality. Youseflu et al., from Iran, published a study entitled “Effects of endometriosis…

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Colorectal Deep Endometriosis Resection and Potential Complications

Colorectal Deep Endometriosis Resection and Potential Complications By Murat Osman

A severe clinical form of endometriosis, deeply infiltrating endometriosis (DIE) is characterized by more aggressive endometriotic lesions commonly involving deeper pelvic or gastrointestinal organs. It causes significant quality of life impairment and morbidity and is increasingly associated with infertility. When…

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Factors affecting the quality of life of women with endometriosis

Factors affecting the quality of life of women with endometriosis By Timur Seckin

Results from a new study suggest that the quality of life of women with endometriosis is significantly affected by their confidence to manage pain and their belief in the evolution of their condition. In this study, led by Rees M. et…

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Deep Endometriosis or Recto-uterine Obliteration Without Endometrioma

Deep Endometriosis or Recto-uterine Obliteration Without Endometrioma By Selma Oransay

The diagnostic help of ultrasound is increasing by its ability to diagnose deep infiltrating and rectouterine pouch obliteration in patients who are suffering from chronic pelvic pain. Clinicians are used to evaluating the rectal and parametrial areas of the endometriotic…

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Antioxidant Enzymes in Endometriosis

Antioxidant Enzymes in Endometriosis By Dr. Youngran Park

Recent attention has been focused on the effect of oxidative stress in the development of endometriosis. Especially, there are several studies regarding glutathione peroxidase (GPX), a major enzyme in removing various reactive oxygen species. In the field of infertility, the…

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The advantages of combined vaginal-laparoscopic approach on voiding dysfunction for rectovaginal endometriosis

The advantages of combined vaginal-laparoscopic approach on voiding dysfunction for rectovaginal endometriosis By Irem Onur

The patients with rectovaginal endometriotic nodules with extensive vaginal infiltration who are managed combined vaginal-laparoscopic approach have a lower risk of postoperative bladder dysfunction when compared to surgery via laparoscopy alone. This is according to a manuscript published in the…

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Inhibiting killer on the move

Inhibiting killer on the move By Yu Yu

The three main forms of endometriosis are superficial, ovarian, and deep endometriosis. The latter is defined by the presence of endometriotic nodules that are deeper than 5 mm. Deep endometriosis is considered the most aggressive and is associated with severe…

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Endometrial polyps of patients with and without endometriosis

Endometrial polyps of patients with and without endometriosis By Nasuhi Engin Aydin

Endometrial polyps are benign local overgrowths comprising both glands and the stroma, and are quite common in gynecological practice. Endometriosis patients also commonly have polyps, which have yielded different features than those from patients without endometriosis.  Dr. Jiangand and associates…

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The impact of laser vaporization on reproductive outcomes in women with endometrioma

The impact of laser vaporization on reproductive outcomes in women with endometrioma By Hale Goksever Celik

Despite extensive research, the optimal method for the management of endometriosis still remains unclear. Excisional surgery is claimed with a more favorable outcome than drainage and ablation regarding the recurrence of disease and symptoms. On the other hand, cyst vaporization…

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A Call for Pan-Canadian Collaboration for the Care and Quality of Life of Endometriosis Patients

A Call for Pan-Canadian Collaboration for the Care and Quality of Life of Endometriosis Patients By Timur Seckin

Wahl KJ et al., from Canada, drew attention to the lack of health care for endometriosis patients who are estimated to be 1 million in number in Canada in their recent brief communication report. The delay in the diagnosis, the…

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Bowel surgery for endometriosis

Bowel surgery for endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. The disease harbors various complications. Deep endometriosis involving the bowel is only one aspect of the condition that has variable phenotypic presentations and pathologic subtypes. Knowledge of the short- and long-term risks of the surgical…

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Benefits of Nerve-Sparing Hysterectomy

Benefits of Nerve-Sparing Hysterectomy By Selma Oransay

The retroperitoneal spread of endometriosis or cancer may involve pelvic autonomic nerves situated on the lateral aspects of uterosacral ligaments, vesicouterine ligaments, and medial aspects of parametria. During the conventional open hysterectomy operations, nerve-sparing excision is very difficult, simply because pelvic autonomic nerves…

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Mental stress promotes mice endometriosis

Mental stress promotes mice endometriosis By Bahar Yuksel

Endometriosis is a disease for which pathogenesis and progression are not fully understood. Inflammation is one of the key candidates that might be related to the creation or progression of endometriosis. In the study conducted by Kawakita et al from…

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Diagnosis and treatment of endometriosis in adolescents

Diagnosis and treatment of endometriosis in adolescents By Irem Onur

The belief that dysmenorrhea, the primary symptom of endometriosis, in adolescents is an inevitable condition seen in menstruation as well as unwillingness to perform diagnostic laparoscopy may cause the delay of diagnosis of endometriosis. This is according to a recent…

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Natural history of spontaneous endometriosis in crab-eating monkeys

Natural history of spontaneous endometriosis in crab-eating monkeys By Nasuhi Engin Aydin

Kaori Hayashi and associates from Shiga University of Medical Science, Japan, published their observations on spontaneously occurring endometriosis in crab-eating monkeys in "Tohoku Journal of Experimental Medicine"https://www.jstage.jst.go.jp/article/tjem/251/4/251_241/_pdf/-char/en. The presence of endometrial tissue outside the uterus, i.e., endometriosis is a progressive prevalent…

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Is there a commonality between endometriosis and systemic lupus?

Is there a commonality between endometriosis and systemic lupus? By Murat Osman

Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect many organs including the skin, joints, the central nervous system, and the kidneys. Women of childbearing age and certain racial groups are at increased risk to develop the condition.…

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Patient-centered care in patients with endometriosis

Patient-centered care in patients with endometriosis By Hale Goksever Celik

The women with endometriosis suffer from several symptoms and signs including dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility which have a detrimental effect on their quality of life. Endometriosis is diagnosed with 7-10 years of delay due to the absence…

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Immune cells and endometriosis pain

Immune cells and endometriosis pain By Dr. Youngran Park

Endometriosis is an estrogen-dependent inflammatory disorder in women. This disease leads to dysmenorrhea, pelvic pain, and infertility. The immune reaction is one of the most widely accepted pathologies of endometriosis. Estrogen dysfunction stimulates immune cells in the peritoneal cavity affecting…

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Voiding Dysfunction after Colorectal Surgery for Endometriosis

Voiding Dysfunction after Colorectal Surgery for Endometriosis By Timur Seckin

Postoperative voiding dysfunction is a less frequent complication of rectal shaving than that of discoid excision or segmental resection in patients undergoing colorectal surgery for endometriosis, regardless of its definition. This is according to a meta-analysis conducted by researchers from…

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Prevalence, Risk factors and Management of Bowel Fistula after Rectosigmoid Surgery for Deep Endometriosis

Prevalence, Risk factors and Management of Bowel Fistula after Rectosigmoid Surgery for Deep Endometriosis By Selma Oransay

Bowel fistula is a severe complication after the colorectal endometriosis surgery, but little is known about its prevalence, and reports on large series are lacking. To discuss specific management on colorectal deep endometriosis, Roman et al. conducted a retrospective study…

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Endometriosis prevalence among adolescents with pelvic pain

Endometriosis prevalence among adolescents with pelvic pain By Irem Onur

An updated review conducted by the investigators at EGA Institute for Women's Health, University College London, United Kingdom, in collaboration with Birmingham Women’s and Children’s Foundation Trust of the Institute of Metabolism and Systems Research at the University of Birmingham…

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Reproductive capacity and recurrence rate after surgery for Stage III/IV endometriosis 

Reproductive capacity and recurrence rate after surgery for Stage III/IV endometriosis  By Bahar Yuksel

If gaining fertility back is the main goal, the surgical removal of endometriosis lesions is globally recognized as first-line therapy. Even though, pre- and postoperative hormone therapy leads to a significant decrease in the spread of the disease measured with the…

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The effects of nutrients on endometriosis-related symptoms

The effects of nutrients on endometriosis-related symptoms By Nasuhi Engin Aydin

A recent literature review from the Netherlands by researchers Emma Huijs and Annamiek Nap, published in "Reproductive Biomedicine Online" puts light on the effects of some nutrients for endometriosis-related symptomatology.  Endometriosis has heterogeneous pathogenesis involving genetic, immunological, environmental, and hormonal…

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Early maternal separation and endometriosis progression in adult mice

Early maternal separation and endometriosis progression in adult mice By Hale Goksever Celik

The quality of life in the women affected by endometriosis depe