By Eylül GÜNA new assessment tool for the multi-dimensional burden of endometriosis
By Eylül GÜN
Endometriosis is a disease that has multiple effects on patients’ lives in various ways. The quality of life, the status of the patient’s relationships, the continuity and productivity in the patient’s education and work environment, and psychological, emotional, and even…
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By Özge ÖzkayaOvarian Cancer Survival in the presence of Endometriosis
By Özge Özkaya
Women with ovarian cancer and histologically proven endometriosis have longer overall survival compared to those with ovarian cancer but no endometriosis, found a study published in the American Journal of Obstetrics & Gynecology. “[…] Women diagnosed as having ovarian cancer…
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By Selma OransayThe added value of transvaginal hydro-laparoscopy for infertile women
By Selma Oransay
The added value of invasive diagnostic laparoscopy has been questioned, postponed by the increased usage of ultrasonography for the evaluation of infertile patients. Gordts et al. from Life Expert Center, Leuven, Belgium have been working on an alternative way called "transvaginal hydro-laparoscopy" to…
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By Bahar YukselThe role of physical examination and interview in Endometriosis Diagnosis
By Bahar Yuksel
Today we know that the most accurate diagnosis of endometriosis necessitates surgery and histopathological examination of the excised lesions. However, many women are misdiagnosed due to various symptoms of endometriosis which mystify gastrointestinal, urinary, and musculoskeletal diseases. Nawrocka-Rutkowska and colleagues…
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The incidence and prevalence of endometriosis in a United States population-based study .
By Selma Oransay
To define the accurate incidence and prevalence estimates of endometriosis among nonselected cohorts in the USA, Christ et al. from the Departments of Obstetrics and Gynecology of the University of Washington, Seattle, planned a retrospective cohort study using the electronic KPWA…
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By Hale Goksever CelikLong noncoding RNAs to predict the endometriosis recurrence
By Hale Goksever Celik
Despite extensive research, the exact pathophysiologic mechanism of endometriosis remains unclear; and the absence of non-invasive biomarkers to diagnose endometriosis is still a big problem both for clinicians and patients. The recurrence of endometriosis is another challenge that is difficult…
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Endometriosis & adolescents: Overcoming the diagnostic delay via education
By Eylül GÜN
Although the diagnosis of endometriosis is still not timely even in adults, due to its common under- or misdiagnosis in adolescents, the diagnostic delay may further cause the adolescent women to wait to seek medical treatment. A group of researchers…
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Chemical Found in Self-Care Products May Be Linked to Endometriosis
By Özge Özkaya
There may be a link between exposure to phthalates and endometriosis according to a new study published in the Journal of Assisted Reproduction and Genetics. Although more research is needed, these findings could be translated into clinical practice according to…
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Transvaginal Ultrasound Accuracy for Uterosacral Ligament, Torus Uterinus and Posterior Fornix Endometriosis
By Selma Oransay
The accuracy of transvaginal ultrasonography for the diagnosis of deep endometriosis depends on the location. The sensitivity is up to 80% when the lesion is in the rectosigmoid, but it decreases up to 66% for the detection of posterior vaginal…
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By Nasuhi Engin AydinThe clues for pain and infertility in endometriosis/adenomyosis complex
By Nasuhi Engin Aydin
Drs. Gruber and Mechsner from Charite University-Berlin, Germany published their comprehensive review on pathophysiological background of endometriosis and adenomyosis in the scientific periodical “Cells”. Chronic pain and fertility problems are the main clinical issue in endometriosis and adenomyosis patients. In order to…
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Technical Facts for the Prevention of Complications After Deep Endometriosis Surgery
By Özge Özkaya
There are no differences in the risk of rectovaginal fistula in women with rectovaginal endometriosis who were managed by a liberal or restrictive policy of preventive stoma according to a study by French researchers published in the Journal of Minimally…
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Non-pharmacological self-care: dietary modifications in women with endometriosis.
By Selma Oransay
The academic interest on the role of diet in endometriosis has grown due to its possible relation with inflammation, estrogenic activity, and menstrual cycles. Multiple dietary strategies and prescriptions are being used to deal with the pelvic pain and gastrointestinal…
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How to measure the length of recto-sigmoid deep endometriosis reliably?
By Eylül GÜN
An in-depth assessment is needed when rectosigmoid deep endometriosis is decided to be treated surgically. Surgery carries a lot of risks and it is not always easy to decide which procedure the patient would benefit the most from. Patient-oriented surgical…
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Urinary Tract Endometriosis
By Bahar Yuksel
Endometriosis is mostly seen in patients of fertile age, and urinary tract endometriosis affects 1.2 to 6% of women with endometriosis. French coloRectal Infiltrating ENDometriosis Study (FRIENDS) group investigated the characteristics of urinary tract endometriosis in 232 patients from 31 centers. Authors…
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A scoping review proposal for the diagnostic and treatment delay of endometriosis
By Hale Goksever Celik
Women with endometriosis suffer from pain for a prolonged time due to diagnostic and treatment delay which is the most challenging aspect of endometriosis. Cromeens et al, from the USA, published a review entitled “Timing, delays, and pathways to the…
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Strong Geographical Gradient in Endometriosis Incidence Identified
By Özge Özkaya
The geographical distribution of new endometriosis cases showed a very strong north-south spatial gradient in the highly industrialized Friuli Venezia Giulia region of Italy, according to a new study published in the International Journal of Environmental Research and Public Health. “The cluster of…
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Not just the pain stops but also the bowel function improves after DIE surgery
By Bahar Yuksel
Bowel endometriosis and the techniques to operate it have always been a challenge. The study conducted by Beraldo et al., from Brazil, highlighted the results of an effective nerve-sparing bowel surgery on endometriosis lesions and its long-term effects on patients. The…
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Exploring a bonafide biomarker to predict endometriosis
By Eylül GÜN
Endometriosis is a complex disease affecting many women in the reproductive age group. As it is important to figure out the mechanisms responsible for the disease, it is also crucial to identify biomarkers that can be used in the diagnosis…
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Promising therapeutic results in experimental endometriosis model
By Nasuhi Engin Aydin
Tiziana Genovese and associates from Italian academic centers reported their pioneering findings in an experimental model of endometriosis administering an anti-tumor agent and glucocorticoid combination, published in the scientific periodical “International Journal of Molecular Sciences”. Endometriosis is a worldwide common disease…
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It is not that simple: endometriomas are almost never alone
By Bahar Yuksel
Endometriomas are the widely and easily diagnosed type of endometriosis. They are usually treated by gynecologic surgeons and are thought to be alone most of the time. The study conducted by Piriyev et al highlighted the coexistence of extraovarian endometriosis…
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Is the presence of nerve fibers in the endometrium associated with endometriosis?
By Eylül GÜN
Endometriosis is a common disease in reproductive women and diagnostic imaging have a limited role in its diagnosis. The gold standard diagnostic method remains to be the histopathological examination of the tissue obtained via laparoscopy. One of its most common…
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Resveratrol, isoflavones and puerarin have favorable in vivo results in endometriosis studies
By Nasuhi Engin Aydin
Xia Cai and associates from research units located in China published their review article on the relationship between phytoestrogens and endometriosis in the scientific periodical named “Pharmacology”. The great variation in the prevalence of endometriosis raises questions in regard to…
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Endometriosis and Rheumatoid Arthritis, Could There Be a Link?
By Özge Özkaya
Patients with endometriosis have a higher risk of rheumatoid arthritis according to a study published in the journal Rheumatology. This finding suggests that rheumatologists should be especially mindful of the possibility of underlying endometriosis when treating women with rheumatoid arthritis.…
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Postoperative Opioid use after Robotic operations for endometriosis, compared to non-endometriosis
By Bahar Yuksel
Endometriosis is a common disease in patients of fertile age, and many patients require surgery. Robotic surgery is accepted as a minimally invasive method in the management of endometriosis and other benign conditions. However, postoperative pain status and the best pain…
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Ureteral endometriosis and its management
By Eylül GÜN
Urinary tract endometriosis prevalence is hard to determine since almost half of the women with this condition appear asymptomatic. The most common form is bladder endometriosis followed by ureteral endometriosis which is seen more rarely. Ureteral endometriosis is usually located…
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Does hyaluronic acid have a role in endometriosis?
By Nasuhi Engin Aydin
Pei-Hsiu Yu and associates from Tainan, Taiwan, published their results of original research on the role of hyaluronic acid in endometriosis formation in a recent issue of "Taiwanese Journal of Obstetrics and Gynecology". Hyaluronic acid, a glycosaminoglycan protein in the…
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Medical Examination Reduces Anxiety in Women With Suspected Endometriosis
By Özge Özkaya
Anxiety levels go down after medical examination in women with suspected endometriosis, found a study by Italian researchers that was published in the Journal of Psychosomatic Research. This was especially pronounced in women who had higher baseline distress and who…
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Analyses of the main classification systems of endometriosis in terms of utrasound, MRI and surgery
By Selma Oransay
Several classifications made by gynecologists, image readers, and radiologists lead to confusion while describing the situation and estimating the progress of endometriosis. Daniela Fischerova team from the Charles University of Prague, Czech Republic, analyzed the main classifications of endometriosis in three…
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Does exercise have an effect on pain perception in women with endometriosis?
By Hale Goksever Celik
Endometriosis is an inflammatory disease causing pain symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain, and also infertility. Several medical and surgical treatment options have been developed to improve quality of life of these women. Despite extensive research, the optimal…
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MicroRNAs in the pathogenesis of endometriosis and infertility
By Eylül GÜN
The gold standard in the diagnosis of endometriosis is laparoscopy and histopathological diagnosis, however search for a non-invasive method has been ongoing. Some biomarkers such as Cancer Antigen 125 have been thought to be useful, but because of their low…
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A hot research topic: macrophage reprogramming for endometriosis treatment
By Nasuhi Engin Aydin
Daria Artemova and colleagues from several research institutes of the Russian Federation have published their review on the cellular aspects of endometriosis related to macrophages, particularly emphasizing promising therapeutic options for the future in "International Journal of Molecular Sciences". Macrophages have…
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The Severity of Pain Does not Predict Endometriosis or its Stage, Study Confirms
By Özge Özkaya
The intensity of pain a woman experiences could predict whether or not she would undergo laparoscopic surgery. However, it could not predict whether she has endometriosis or in case she did, the severity of her disease. This is according to…
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The relationship between microbiota and endometriosis
By Eylül GÜN
Endometriosis is a multifactorial and complex disease that results in an inflammatory state. This persistent inflammatory state is known to cause immune dysregulation. In the immunopathogenesis of endometriosis, activated macrophages, increased neutrophils, impaired natural killer cells, altered T-cell differentiation, and…
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Predictors for achieving pregnancy in patients with adenomyosis and endometriosis
By Bahar Yuksel
Adenomyosis and endometriosis are benign conditions, however, both situations are associated with deterioration of life quality, a requirement of hospital administrations, and infertility. Laparoscopic surgery is the main treatment option especially for women who desire pregnancy. Shi and colleagues aimed…
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A pictorial overview of abdominal wall endometriosis
By Hale Goksever Celik
Abdominal wall endometriosis is the most frequent location of extrapelvic endometriosis, and defined as the presence of ectopic endometrial tissue between the peritoneum and the skin through the abdominal wall. Although obstetric or gynecologic surgical history is indispensable for the…
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New molecular insights in endometriosis pathogenesis
By Nasuhi Engin Aydin
Dr. Rosalba Siracusa and associates from Messina University, Italy, have published their research on cellular pathogenesis of experimental endometriotic lesions in the recent issue of the "International Journal of Molecular Sciences". Endometriosis is a debilitating chronic estrogen-dependent inflammatory condition and…
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Outcomes of chronic pelvic pain of endometriosis after laparoscopic surgery
By Selma Oransay
The prevalence of endometriosis is up to 35-50% among patients with pelvic pain. Among several medical and surgical options to relieve chronic pelvic pain, surgical options are the preferred method but this depends on patients' age, fertility desire, and disease…
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How Does Endometriosis Affect Patients Quality of Life?
By Özge Özkaya
Health-related quality of life is significantly lower in patients with endometriomas or deep infiltrating endometriosis compared to women without the disease. This is according to the results of a recent study in adult Spanish women that was published in the "International…
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Postoperative ovulation induction in infertile women with minimal to mild endometriosis
By Hale Goksever Celik
Infertility is an important problem that is encountered in 30-50% of women with endometriosis. Several etiopathogenetic mechanisms for the development of reproductive problems in women with endometriosis have been proposed including abnormal peritoneal microenvironment, ovarian dysfunction and/or decreased oocyte quality,…
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Combined contraceptive pills and immune system cells in the endometriotic cyst wall
By Nasuhi Engin Aydin
Dr. Wanwisa Waiyaput and associates from Mahidol University, Bangkok, Thailand, have published their results on the immune regulatory cells of the surgically resected endometriotic cyst walls in the “Journal of Ovarian Research”. The defective immune response is believed to have…
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Is the information on Facebook groups about endometriosis accurate?
By Eylül GÜN
The use of social media platforms has been increasing day by day. The coronavirus pandemic has attributed to this immensely. Facebook pages and groups are among the most commonly used platforms to share knowledge, seek emotional support, and learn. While…
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Adhesion Barrier Helps After Endometriosis Surgery
By Özge Özkaya
An adhesion barrier, named "4DryField® PH" significantly reduced the formation of adhesions following endometriosis surgery, according to a new study by German scientists. The formation of adhesions following endometriosis surgery is a severe problem that affects 90% of patients. The…
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Women reject using hormonal drugs for endometriosis, an accelerating need for nonhormonal medications
By Bahar Yuksel
Although the pathophysiology of endometriosis is poorly understood, endocrine drugs are widely used for reducing inflammation and patients’ symptoms. Burla and colleagues aimed to evaluate the patients’ thoughts and expectations about the endocrine drugs which are used in the treatment…
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Managing Persistent Pelvic Pain in a distinct "pain" clinic
By Selma Oransay
Persistent pelvic pain is an important problem producing physiological stress and productivity loss during the reproductive period of women. A specific pelvic pain clinic named "Mater Health Persistent Pelvic Pain Clinic" was established in 2017 in a part of the emergency…
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Retinol-binding protein in endometriosis pathogenesis
By Nasuhi Engin Aydin
Dr. Jae Chul Lee and associates from the Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, have published the recent results of their research on endometriosis regarding the role of retinol-binding protein4…
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What causes distress in women with endometriosis?
By Eylül GÜN
Endometriosis is a disease that affects a woman’s life from many different aspects; emotionally, sexually, and physiologically. With the burden of the distress caused by the disease, most women suffer from anxiety and depression. This results in lower self-esteem and…
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The Surgical Management of Endometriosis of the Ureter and Bladder
By Özge Özkaya
Laparoscopic surgery is feasible and safe to manage endometriosis of the ureter and bladder, according to a new study published in the Journal of Minimally Invasive Gynecology. According to the authors of the study, ureteral resection is more strongly associated…
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Factors affecting complications and the recurrence of operated deep infiltrating endometriosis
By Selma Oransay
Deep infiltrating endometriosis is classified as penetrating the endometrial tissues more than 5 mm deep on the peritoneal surface, mainly uterosacral ligament, rectovaginal septum, ovarian fossa, pelvic peritoneum, bowels, ureters, and bladder. Treatment of the disease depends on the need…
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The higher the cyst fluid iron concentration, the more severe the pain symptom for endometrioma
By Hale Goksever Celik
Endometriosis usually is encountered in three different forms: superficial peritoneal endometriosis, ovarian cysts (endometrioma) and deep infiltrating endometriosis. Endometrioma can be identified as cystic lesions consisting of dark brown endometrial fluid and are sometimes referred to as "chocolate cysts." The presence…
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Patient- centeredness in endometriosis
By Bahar Yuksel
Endometriosis is common in fertile age, and women with endometriosis are suffering from serious symptoms including pelvic discomfort, dysmenorrhea, and infertility. Due to resemblances of endometriosis symptoms with other diseases, most endometriosis patients are faced with delays in diagnosis. To…
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Migraine, endometriosis and plasma "Calcitonin Gene-Related Peptide"
By Eylül GÜN
Calcitonin gene-related peptide (CGRP) is a neurotransmitter that takes part in migraine and is now thought to have a role in endometriosis. The role of CGRP is well known in migraine, it is released from neurons during acute attacks and…
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Vulvo- Perineal Endometriosis: From diagnosis to treatment
By Bahar Yuksel
Vulvo- Perineal endometriosis is a very rare condition that should be kept in mind to be diagnosed and treated. Due to its very rare occurrence, most of the information in the literature on vulvo-perineal endometriosis is based on case reports…
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The need for the standardization of diagnostic protocols for "adenomyosis"
By Nasuhi Engin Aydin
Dr. Squillace and associates from Brasilian Academic and Health Centers published their paper titled “Adenomyosis and in vitro fertilization impacts- a literature review” in a recent issue of "JBRA Assisted Reproduction". As common gynecological ailment adenomyosis frequently coexists with endometriosis.…
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The effect of COVID-19 pandemic on patients with endometriosis
By Bahar Yuksel
COVID-19 pandemic and related conditions, including transport restrictions, social isolation, and difficulties accessing the professional health system, affected many women’s healthcare and daily routine. Evans and colleagues investigated the impact of COVID-19 and COVID-19 related parameters on endometriosis patients’ health…
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The genomic linkage between ovarian cancer and endometriosis
By Eylül GÜN
Endometriosis has been proven to be the precursor of ovarian clear cell and endometrioid carcinomas, however, it is not well understood why and how endometriosis goes into malignant transformation. To address this issue, in their review article, Dr. Yachida and…
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How to predict the complications after laparoscopic bowel resection in women with endometriosis
By Hale Goksever Celik
The endometriotic lesions infiltrating the bowel wall more than 5 mm. are called "deep infiltrating endometriosis". The patients having bowel involvement may have constipation, diarrhea, tenesmus, or rectal bleeding. Surgical management is the main treatment modality to provide benefits on pain, infertility,…
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Endometriosis from the "EVOLUTIONARY" point of view
By Nasuhi Engin Aydin
Natalie Dinsdale and associates from the Canadian Simon Fraser University Department of Biological Sciences published a critical review titled “ The evolutionary biology of endometriosis” in a recent issue of the journal “Evolution, medicine and public health”. This review focuses…
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The Communication Gap Between Specialists for Endometriosis Diagnosis and Management
By Eylül GÜN
An approach to help the different specialties which work as a team but lack sufficient communication in endometriosis management build better communication was proposed by Leonardi et al. from Australia and Canada in their opinion article which was published in…
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Endometriosis alters women’s self-behavior
By Bahar Yuksel
Endometriosis diagnosis is given to almost 15% of women of reproductive age. Although endometriosis could be asymptomatic, many women with endometriosis are faced with several symptoms including chronic pelvic pain, dysmenorrhea, dyspareunia, dyschezia, dysuria, and infertility. The wide variability of…
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Evaluation of preoperative risk factors of ureteral endometriosis
By Selma Oransay
Endometriosis affects the urinary tract in 1% to 5.5% of the patients, and among them, bladder involvement is 70-85%, while ureteral involvement alone is 9% to 23%. Ureteral endometriosis is most commonly unilateral, especially on the left side, usually affecting…
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Promising potential research topic: diagnostic biomarkers for endometriosis
By Nasuhi Engin Aydin
Dr. Toczek and collegues from the Department of Gynecology, Obstetrics and Oncological Gynecology of Medical University of Silesia in Katowice, Poland, have published a review paper on possible diagnostic aid of cytokines in endometriosis. This review appears in May issue…
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Endometriosis Surgery Improves Sex Life
By Özge Özkaya
Women who underwent laparoscopic resection surgery to treat their deep infiltrating endometriosis had improved sexual quality of life and health-related quality of life according to a new study published in the Journal of Minimally Invasive Gynecology. These findings are important…
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Myeloid-Derived Suppressor Cells are gaining importance in endometriosis
By Nasuhi Engin Aydin
Dr. Wertel and associates from Polish academic centers published their sentimental review paper on the role of "Myeloid-Derived Suppressor Cells" in human diseases, in a recent issue of Cells. Endometriosis, the most common gynecological disease affecting about 10% of women globally,…
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Postoperative infertility management using Endometriosis Fertility Index in endometriotic women
By Selma Oransay
"Endometriosis Fertility Index '' score, described by the World Endometriosis Society in 2017, is a robust score and assists to predict the spontaneous pregnancy rate of women with endometriosis, within 3 years after their operation. Its calculation is possible by patient…
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Could There Be a Relationship Between Endometriosis and the "Restless Leg Syndrome"?
By Özge Özkaya
Women with endometriosis have a significantly higher prevalence of restless leg syndrome according to a study published in the scientific journal "Frontiers in Endocrinology". This is the first study highlighting such an association between the two conditions. These findings are important…
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Progestin suppression for endometriosis before IVF
By Hale Goksever Celik
“Dienogest is a suitable and safe substitute for GnRHa pretreatment in endometriosis patients”, according to the Khalifa et al., from Egypt. Endometriosis is one of the leading reasons for infertility due to decreased oocyte/embryo quality, fertilizability, tubal function, and aberrant endometrial…
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The endless burden: sexual dysfunction and endometriosis
By Bahar Yuksel
The relationship between endometriosis and sexual health in women is one of the hottest topics in obstetrics and gynecology practice. There are some previous reports that investigated the effect of endometriosis on the loss of libido, arousal disorder, orgasmic dysfunction,…
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Surgery for the Treatment of Endometriosis of the Diaphragm and Thorax
By Özge Özkaya
Diaphragmatic and thoracic endometriosis starts in the abdominal wall of the diaphragm and later invades the thorax, based on findings from a series of patients surgically treated for the disease, reports a study published in the Journal of Gynecology Obstetrics…
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What Happens to Endometriosis Patients After Endometriosis Surgery?
By Özge Özkaya
Although few patients with endometriosis who undergo a hysterectomy need repeat surgery, up to 25% of them need minor surgery. Around 20% of patients who undergo conservative surgery with ovarian preservation require additional endometriosis surgery. Up to one in three…
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Endometriosis in intestine! Segmental resection or linear nodulectomy?
By Bahar Yuksel
Intestinal involvement of endometriosis is common, and the incidence was defined between 45-56%. Previous studies investigating the role of surgery in the management of intestinal endometriosis reported improvement of life quality in up to 95% of cases following surgery. However,…
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Optimal management of infertility in endometriosis patients
By Hale Goksever Celik
Pelvic pain and infertility are the main symptoms of endometriosis patients. Although the pathophysiological mechanism for infertility is not clearly understood, there are several theories explaining decreased fertility potential in women with endometriosis. Ata and Telek, from Koc and Istanbul Universities…
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The association of chronic endometritis, endometriosis and tubal infertility
By Selma Oransay
Holzer et al. from the Department of Gynecologic Endocrinology and Reproductive Medicine of Medical University of Vienna, Austria, set up apilot prospective cohort study to evaluate the relationship between chronic endometritis, infertility and endometriosis. The results of the study were recently…
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Endometriosis and susceptibility to COVID-19
By Nasuhi Engin Aydin
Dr. Moazzami and associates from Pars Advanced and Minimally Invasive Medical Manners Research Center, Tehran, Iran have published their results on COVID-19 in endometriosis patients in the medical journal named "BMC’s Women’s Health". COVID-19 is still an emerging critical global health problem…
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A gentle touch on nerves affects dyspareunia
By Bahar Yuksel
Endometriosis is a common disorder among women. Previous studies reported endometriosis-related deterioration of the quality of life. Deep dyspareunia is a common symptom of endometriosis and young patients face dyspareunia twice as much. Surgical treatments are alternative to medical therapies in cases…
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Improvement of the quality of life after surgery for deep infiltrating endometriosis.
By Selma Oransay
Deeply infiltrating endometriosis is the most severe form among the endometriosis types. The required laparoscopic approach is the appropriate excision of endometriotic foci from pelvis, by consideration of failure and side effects of the medical treatments. The specialist endometriosis centers…
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Problems in the treatment of deep infiltrating endometriosis
By Bahar Yuksel
The Deep Infiltrating Endometriosis (DIE) is very aggressive in nature with infiltrating the whole pelvic, colon, rectum, bladder, ureter, and pelvic wall. D’Alterio and colleagues analyzed the advantages and disadvantages of both medical and surgical therapies for DIE. The authors…
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Postoperative long-term estro-progestin therapy for endometrioma
By Selma Oransay
After the removal of ovarian endometriomas, the major concern is the high recurrence rate of symptoms and endometriotic cysts. The estimated recurrence rate of endometriomas is up to 50% at 5 years after surgery. To prevent the recurrence, postoperatively long-term…
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By Dr. Youngran ParkAutophagy, Endometrium and Endometriosis
By Dr. Youngran Park
Autophagy, or autophagocytosis, is a self-digestion process by which cells recycle non-functional proteins to repurpose them. Unwanted cellular parts in cytosolic material are first isolated within double-membrane vesicles called the autophagosome, which subsequently fuses with the acidic lysosome. Autophagy is a survival…
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Immune-mediated conditions and endometriosis in adolescents and adults
By Hale Goksever Celik
The most common presenting complaints of endometriosis are mainly pelvic pain and infertility, commonly in relation to the menstrual period. Affected women demand therapy for these symptoms. Immunologic diseases such as autoimmune and/or inflammatory diseases, allergies, asthma, previous mononucleosis infection,…
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Testosterone levels effect embryo implantation rates in patients with endometriosis
By Bahar Yuksel
Endometriosis is associated with infertility either causing poor oocyte and embryo qualities or poor endometrial receptivity. The effect of androgen levels on IVF outcomes has been described earlier, but the present study conducted by Ling Huang et assocates is the…
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Endometriosis of the Diaphragm, What do the Doctors Know About it?
By Özge Özkaya
The median time between the first consultation with a primary care physician and receiving a diagnosis of endometriosis of the diaphragm is two years according to a study by U.K. researchers. In the worse case, it took 23 years for…
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Fertilization rate and pregnancy outcome in IVF cycles of endometriosis.
By Selma Oransay
Endometriosis affects the pelvic cavity, uterus, ovaries and causes impaired fertility as a result. The chronic inflammatory nature of this disease negatively impacts the oocyte quality, maturation, and fertilization. Obviously, fewer oocytes can be harvested in the IVF cycles of…
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Adenomyosis: accuracy of the diagnostic methods and the synchronism with deep infiltrating endometriosis
By Nasuhi Engin Aydin
Dr. Alborzi and associates from Shiraz University of Medical Sciences, Iran, have published their comprehensive retrospective research conducted on 3725 patients with clinical symptoms of endometriosis over a period of 3 years, in "Reproductive Sciences" medical journal. A relationship between…
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Can we measure the severity of endometriosis?
By Dr. Youngran Park
Endometriosis is an enigmatic disease associated with serious morbidity and change in the quality of life. Unfortunately, there is no specific test for the diagnosis of endometriosis. While many markers were evaluated in many research studies for the noninvasive diagnosis…
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Postoperative treatment and pregnancy points to decreased recurrence risk for ovarian endometriosis
By Hale Goksever Celik
Endometriosis is a disease most frequently diagnosed in women of reproductive age and negatively affects the quality of life. The most common localization for endometriosis is ovaries with a prevalence of 17-44%. Laparoscopic ovarian cystectomy performed as excision or ablation…
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Endometriosis, ART, fertility preservation
By Selma Oransay
This review entitled "The impact of endometriosis on the outcome of assisted reproductive techniques: role of fertility preservation" was written by Necula et al. from Gynecology and Obstetrics Unit, Biel, Switzerland, and recently published in the journal "Hormone, Molecular Biology and Clinical…
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Tubo-ovarian abscess and endometriosis
By Bahar Yuksel
A tubo-ovarian abscess is the result of pelvic inflammatory disease in women and the previous reports demonstrated that almost one of the third women with a pelvic inflammatory disease had a tubo-ovarian abscess. The main treatment modalities for tubo-ovarian abscess…
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Pain Sensitization and What Should Be Done About it?
By Özge Özkaya
Pain sensitization and lumbopelvic impairments are common among women with endometriosis, especially if they have advanced stage disease. This is according to a study by researchers in Spain that was published in the scientific journal "Pain Medicine". The finding underscores the…
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Diaphragmatic defects, liver herniations and catamenial pneumothorax
By Nasuhi Engin Aydin
Dr. Arakawa and associates from The Jikei Katsushika Medical Center, Japan, have published their recent case of catamenial pneumothorax with diaphragmatic defect and liver herniation in the "Journal of Cardiothoracic Surgery". Catamenial pneumothorax is an uncommon condition with a reported…
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Erastin, Ferroptosis and Endometriosis
By Dr. Youngran Park
Iron overload has been linked to endometriosis. There are abundant free iron and high oxidation in ectopic lesions, probably due to retrograde menstruation. Interestingly, iron overload in endometriosis activates NF-kB signaling and results in proinflammatory communication. More clear pieces of…
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By Yu YuCancer, is that a real risk?
By Yu Yu
Endometriosis is non-malignant but shares some similar features with cancer, such as the occurrence of local and distant foci, the ability to resist cell death, and the ability to invade other tissues, causing damage to the organs. Endometriosis also generates…
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Controlled use of bipolar cauterization as an alternative to endometrioma cystectomy
By Hale Goksever Celik
The main symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Ablation or coagulation of the cyst wall following laparoscopic drainage of endometrioma may be an alternative treatment for patients with pregnancy intention. Carbon dioxide, laser, and plasma energy…
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Perineal Endometriosis, How Soon Does it Return After Surgery?
By Özge Özkaya
The higher the body mass index (BMI) of a woman during delivery and within one month after delivery, the quicker the symptoms of perineal endometriosis return. This is according to a recent study that appeared in the World Journal of…
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The influence of endometrioma and surgery on ovarian reserve
By Dr. Youngran Park
Women with endometriosis and endometrioma, often have subfertility. These patients present considerable problems for the evaluation of ovarian reserve. One of the well-known ovarian reserve biomarkers is anti-Müllerian hormone (AMH) levels. So far, it was known that the reduction of…
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Selected Blood Inflammatory Biomarkers May Help Identify Endometriosis
By Özge Özkaya
Levels of inflammatory biomarkers in the blood differ between women with endometriosis and those without the disease. Levels of some biomarkers also differ according to the stage of endometriosis. This is according to a new study by Polish scientists published…
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“Advanced gynecological ultrasound” for women with suspected endometriosis
By Hale Goksever Celik
Different clinical forms of endometriosis such as superficial endometriosis, endometrioma, and deep infiltrating endometriosis are present. Although no specific diagnostic tool is available for endometriosis, clinical findings, physical examination and imaging including transvaginal ultrasound and MRI are helpful to determine…
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Endometriosis and possible cardiovascular outcomes
By Selma Oransay
A retrospective population-based cohort study from the Institute of Applied Health Research, University of Birmingham, Birmingham, the UK, investigated the long-term cardiovascular outcomes of women with endometriosis. The study included 279,759 women in total, 20,1% (>56.000) were patients with surgically…
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The effects of endometriosis on life satisfaction.
By Bahar Yuksel
Endometriosis is well-known for its debilitating effects on women suffering from it. In the review conducted by Masoumeh Namazi et al, the authors have collected studies searching for the wellbeing of women with endometriosis. They have analyzed 46 studies that…
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Endometrial receptivity after the removal of ovarian endometriotic cysts
By Nasuhi Engin Aydin
Mikhaleva and associates from the "Russian Research Institute of Human Morphology" published their results in “Reproductive Sciences” yielding their novel morphological findings of eutopic endometria in patients following surgical excision of endometriotic ovarian cysts. Current therapeutic measures are targeting to…
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Managing the physical and emotional effects of endometriosis
By Hale Goksever Celik
Endometriosis is known to affect 5-10% of the general population, but some women are underdiagnosed due to physical and psychological disability. Due to the symptoms including dysmenorrhea, dyspareunia, chronic pelvic pain and infertility, endometriosis has a negative effect on the quality…
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Environmental to occupational exposure, and possible risk factors for endometriosis.
By Selma Oransay
Many objects in daily use are made of plasticizing agents. Studies suggest that chronic exposure to these agents are toxic to reproductive organs and cause metabolic disorders. For example, diethyl phthalate is still in use in cosmetic products. Caporossi et…
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DNA damage response in eutopic endometria of endometriosis patients
By Dr. Youngran Park
The DNA damage response (DDR) is a network of cellular pathways that sense, signal, and repair the lesions occurring in DNA. Surveillance proteins that monitor DNA integrity activate the DNA repair pathways in response to DNA damage and try to prevent the generation of potentially deleterious mutations. Endometriosis is an estrogen-dependent…
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Impaired fertility potential in endometriosis patients
By Hale Goksever Celik
Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis and sperm movements. Garcia-Fernandez and García-Velasco, from Edinburgh, UK and Madrid, Spain, published a mini-review titled “Endometriosis and Reproduction: What We Have…
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Oxygen deprivation (hypoxia) has a critical role in the pathogenesis and progression of endometriosis
By Nasuhi Engin Aydin
Dr. Wan-Ning Li and associates from academic institutions from Taiwan have published their review paper on the role of hypoxia and possible therapeutic outcomes in the medical journal named "Reproduction" recently. Endometriosis is an important ailment with huge medical and social…
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Endometriosis and the risk of Systemic lupus Erythematosus: A report from Taiwan
By Selma Oransay
Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage that affects mostly women, with an M:F ratio of 1:9. Recent evidence has also shown that endometriosis is…
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The incidence of endometriosis and pelvic pain in transgender man
By Bahar Yuksel
Transgender operations are quite common all around the world and hysterectomies are performed almost 1 in 5 of this population. The studies conducted until now mostly evaluated operative and postoperative outcomes, but the present research also questioned the preoperative symptoms and…
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Nanomedicines for Endometriosis
By Dr. Youngran Park
Scientific research on nanoparticles is intense as they have many potential applications in medicine. Nanomaterials have been widely explored for imaging and treatment of various diseases, especially cancer, over the recent twenty years. The absence of non-invasive diagnostic tests and…
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The improvement of fertility rate and symptoms of superficial endometriosis following laparoscopic peritoneal stripping
By Selma Oransay
Pain, in the form of diverse entities, including dyspareunia, dysuria, dyschezia, is the main symptom of endometriosis patients. The severity of pain is independent of the extent and the location of the disease, and generally causes a negative impact on…
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Vitamin D supplementation, endometriosis symptoms and metabolic profiles
By Hale Goksever Celik
Patients with endometriosis suffer from dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. These women are also at higher risk for ovarian and breast cancer, cardiovascular events, and metabolic abnormalities. Several medical and surgical alternatives have been recommended to these patients…
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Cancer risk Evaluation in Korean Endometriosis Cohort
By Bahar Yuksel
The relationship between endometriosis and cancer has always been challenging. The previous studies revealed an increased risk in endometriosis-associated ovarian cancers regarding the alterations in cancerogenic genes or by the effect of iron and hem coming with retrograde menstruation and…
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A comparison of symptomatology and histopathologic features in surgically resected colorectal endometriosis
By Nasuhi Engin Aydin
Dr. Tschan and associates from Feldrich Academic Teaching Hospital, Austria published their retrospective research on patients requiring colorectal surgical resection for endometriosis in European Journal of Medical Research. Bowel endometriosis requiring colorectal surgical resection causes important morbidity. The rectum and…
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Antioxidant therapy for the endometriosis pain
By Selma Oransay
Ts the protective defense mechanism of cells, hence the destruction of balance between oxidants and antioxidants in our body is called "redox imbalance". The major oxidants are reactive oxygen species (ROS) that are involved in multiple cellular processes by physiologically…
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Ovarian, breast and endometrial cancer coexisting with endometriosis.
By Selma Oransay
The invasive nature of endometriosis results in calling the disease " benign cancer". The transformation of endometriosis to malignancy is rare, but when compared to the general population, the relative risk of developing ovarian cancer is 4.2 times greater especially…
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Self-management and the quality of life in women with endometriosis
By Hale Goksever Celik
Endometriosis symptoms can range from mild to severe. The most common presenting complaints are mainly pelvic pain and infertility. There is no doubt that the physical and mental quality of life of these women is adversely affected. There are several studies…
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The role of hormonal treatment after endometriosis surgery
By Bahar Yuksel
Postoperative hormonal suppression after endometriosis surgery still does not have a uniform approach. The meta-analysis study conducted by Zakhari et al. aimed to find a significant answer regarding this burden. They analyzed the database systems including MEDLINE, Embase, Cochrane CENTRAL,…
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By Irem OnurThe association between body size and endometriosis
By Irem Onur
Until today there have been few studies investigating body size in childhood and adolescence in women with endometriosis. A new study published recently in the journal Acta Obstetricia et Gynecologica Scandinavica provides further evidence of the associations between endometriosis, body…
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"Speckle sign": a novel transvaginal ultrasound finding for posterior compartment endometriosis
By Nasuhi Engin Aydin
Dr. Balcacer and associates from three medical institutions located in the USA report the results of their retrospective study on deep infiltrating endometriosis utilizing transvaginal ultrasound examination and the proposed “speckle sign” in the "Journal of Ultrasound Medicine". Pelvic ultrasound…
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By Ellen TumimbangOxidative stress, reactive products, detoxification, endometriosis and pain
By Ellen Tumimbang
Oxidative stress is one factor known to be involved in the pathogenesis, progression, and establishment of endometriosis in women. During oxidative stress, excess reactive oxygen species as a secondary by-product of lipid peroxidation and reactive aldehyde including 4- hydroxynonenal…
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Live Birth Rate in Women Who Underwent Fresh Embryo Transfer Using Freshly Retrieved Donor Oocytes
By Hale Goksever Celik
One of the important clinical findings in women with endometriosis is reproductive problems. Infertility can be encountered in up to 50% of women with endometriosis and up to 50% of women with infertility can be diagnosed with endometriosis. Several pathophysiologic…
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The largest series of diaphragmatic endometriosis
By Bahar Yuksel
Diaphragmatic endometriosis is one of the most common extra pelvic endometriosis types, yet the correct incidence is unclear. In the study conducted by Ceccaroni Marcello et al from the International School of Surgical Anatomy, Verona, Italy, the authors analyzed the…
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What is the cause of Dienogest-resistance in patients with endometrioma?
By Selma Oransay
Endometriosis may cause infertility in women, leading to adhesions in the pelvis, besides affecting the ovaries. Clinicians concern about the child-bearing desire of their patients when treating them surgically or with hormonal therapy. Dienogest (DNG) is a kind of progestin,…
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Time for noninvasive serum markers for endometriosis diagnosis
By Nasuhi Engin Aydin
Dr. Onur Guralp and associates from Germany and Turkey published their results on serum markers predicting endometriosis in the "Journal of Obstetrics and Gynaecology". Still, in 21st-century medicine, doctors can not diagnose endometriosis using biochemical serum markers. Proposed serum markers…
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Analysis of women with endometriosis-related pain before the multidisciplinary endometriosis care management
By Irem Onur
Endometriosis patients are generally treated by a single provider and they frequently report dissatisfaction with care. To decrease diagnostic delays, improve pain management, and promote patient satisfaction, multidisciplinary endometriosis centers emerged. But, baseline data assessing the efficacy of the multidisciplinary…
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High-dose progestin intake and sexual functions in endometriosis patients
By Selma Oransay
Dr. Oppenheimer et al. from the Department of Reproductive Medicine and Fertility Preservation of Antoine Beclere University Hospital, Clamart, France, recently published this bi-center observational prospective study in "Acta Obstetrica et Gynecologica Scandinavica". The study was designed to put forth…
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Endometriosis, Fatigue and Productivity
By Ellen Tumimbang
Fatigue is one of the prominent and distressing symptoms of endometriosis-associated with insomnia, depression, pain, occupational stress, and reduced health-related quality of life. Endometriosis-related fatigue causes significant impairments in workplace productivity and daily activities of women with endometriosis. Loss of…
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Postoperative pregnancy rate in infertile women with deep infiltrating endometriosis
By Hale Goksever Celik
Deep infiltrating endometriosis (DIE) is fibrous/muscular infiltration of organs and anatomical structures containing endometrial tissue below the peritoneum regardless of the depth of infiltration. Another definition describes DIE as infiltration of the peritoneum by endometriotic lesions deeper than 5 mm. Pain,…
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Deep endometriosis treatment options based on the patient's decision
By Selma Oransay
Deep endometriosis, defined as endometriotic lesions penetrating deeper than 5 mm into the peritoneum comprise approximately 20% of all endometriosis cases. This invasive disease causes a significant reduction in the quality of life, social participation, and sexual health of affected…
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KEYNOTE: Excision Without Mutilation: It’s Possible! - Arnaud Wattiez, MD
By Özge Özkaya
In his keynote lecture, Dr. Wattiez talks about the pros and cons of endometriosis surgery and the importance of tailoring endometriosis surgery to individual patients. “Endometriosis is a disease that degrades patient’s wellbeing," Dr. Wattiez says and gives some examples…
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Exploring the Role of Neuropathy in Re-Operative Endometriosis - Marc Possover, MD, PhD
By Özge Özkaya
Prof. Possover starts his presentation by summarizing the possible cause of pelvic neuropathy following endometriosis surgery. Pelvic neuropathy is the damage or dysfunction of the pelvic nerve. Prof. Possover explained that this could either be due to incomplete surgery, disease…
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Operative techniques for Deep Endometriosis Surgery - Shaheen Khazali, MD
By Özge Özkaya
In this presentation, Dr. Shaheen Khazali, an endometriosis surgeon specialized in gastrointestinal and urinary tract endometriosis excision and in neuropelveology, talks about the general principles and some techniques for endometriosis surgery focusing on rectovaginal endometriosis. He also describes the "ten…
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Laparoscopic Approach to Rectus Muscle Endometriosis and Inguinal Endometriosis - Ted Lee, MD
By Selma Oransay
Rectus muscle endometriosis and inguinal endometriosis are two rare types of endometriosis. Operation room videos of several patients with different rectus muscle endometriosis and inguinal endometriosis are shared during the presentation of Dr. Lee to clarify the methods of the…
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Separation of epithelia and stroma components in endometriosis lesions yields remarkable molecular points - Ie-Ming Shih, MD, Ph.D.
By Nasuhi Engin Aydin
The pathologies of adenomyosis and endometriosis are unique among non-malignant gynecological diseases and provide fertile research topics. Ectopic endometrial tissues may have distinct molecular changes distinct from eutopic endometria despite having similar morphology. In this regard, there are intriguing suggestions as…
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Exploring Pelvic Pain: Deep to Ischial Spine Including Pre-Sacral Roots - A. Taner Usta, MD
By Irem Onur
Chronic pelvic pain is defined as pain in the pelvic area that lasts for 6 months or longer and results in functional or psychological disability or requires intervention and treatment by the American College of Obstetrics and Gynecologists. There are…
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Why Persistent or Recurrent Endometriosis Happens? - Dan Martin, MD
By Ellen Tumimbang
The objectives of Dr. Martin in this presentation are to understand the difficulties in recognition of deep and hidden endometriosis, difficulties in recognition of small lesions of micron size, and differentiate the look-alike lesions of endometriosis. He addressed overcoming these…
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Role of Prophylactic Oophorectomy in Endometriosis Patients with Ovarian Cancer History in the family - Farr Nezhat, MD
By Özge Özkaya
Dr. Nezhat starts his presentation by outlining his objectives, which are to review the basics of cancer genetics, give an overview about endometriosis and ovarian cancer, discuss the pathogenesis of malignant transformation of endometriosis, and talk about the clinical implications…
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Further Evidence that endometriosis is related to tubal or ovarian cancer - Togas Tulandi, MD
By Selma Oransay
Most authors suggest an association of endometriosis mainly with clear cell, low-grade serous, and endometrioid ovarian cancer. But in two large cohort studies, no correlation between them is reported (Olson et al. 2002 and Tseng et al. 2019) Dr. Tulandi…
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Insoluble Dilemma of Adenomyosis: Diagnosis, Management, and Treatment - Errico Zupi, MD
By Selma Oransay
The prevalence of adenomyosis has been reported to range from 1% to 70% in different studies. This large range can be explained by the lack of standard diagnostic criteria by imaging modalities or pathological analyses. Sixty-five% of the women with adenomyosis…
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It is time for redefining endometriosis with our contemporary scientific knowledge - Philippe Koninckx, MD, Ph.D.
By Nasuhi Engin Aydin
Endometriosis defined as endometrium-like tissue outside the uterus has a poorly understood natural history. It is a heterogeneous disease having genetic-epigenetic features with many biochemical changes in the lesions. The Sampson hypothesis of implanted endometrial cells following retrograde menstruation is not…
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Urological Challenges in Endometriosis Surgery - Guenter Noe, MD
By Özge Özkaya
In this presentation, Dr. Guenter Noé, Head of Department of Rheilandklinikum Dormagen in Germany talks about endometriosis affecting the urinary tract. Dr. Noé starts by describing the different parts of the urinary tract that can be affected by endometriosis including…
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Implantation failure in endometriosis patients - Jovana Lekovich, MD., PhD.
By Hale Goksever Celik
Endometriosis is one of the leading reasons for infertility due to decreased oocyte/embryo quality, fertilization ability, tubal function, and aberrant endometrial receptivity. Whether this failure is caused by oocyte/embryo or eutopic endometrium is one of the investigated topics in endometriosis…
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Fixing holes: prevention and treatment of complications - Jon Einarsson, MD, MPH
By Selma Oransay
Dr. Einarsson shared his operating room video screens during his speech for discussing four major complications (ureter, bladder, bowel, and vascular) of endometriosis surgery and the ways to repair them. Fixing the ureter damage: Endometriotic nodules may settle on the tract…
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Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD
By Selma Oransay
The removal of endometrioma may affect ovarian reserve because healthy follicles near endometrioma could also be excised during this procedure. Another concern about the ovarian reserve is that it may be already low before the surgery. Anti Mullerian Hormone (AMH)…
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In vitro fertilization protocols in endometriosis patients - Pinar Kodaman, MD., PhD.
By Hale Goksever Celik
Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis, and sperm movements. Even though the disease stage and presence of endometrioma is negatively correlated with infertility, it is unpredictable which women…
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Could Cosmetics and Personal Care Products Increase the Risk of Endometriosis?
By Özge Özkaya
The use of cosmetics and personal care products may be increasing the risk of endometriosis according to a study by Spanish researchers that was published in the journal "Environmental Research". This finding suggests that restricting the use of these products may…
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Endometriosis and the sexual relations of the couples
By Selma Oransay
From the viewpoint of endometriotic women, the pain during the penetration is not the only complaint. They also have growing depression and anxiety leading to difficulties with their social and sexual relationship, work, and study. The emotional impact of sub-infertility,…
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A Possible genetic target for endometriosis treatment
By Dr. Youngran Park
Mutations in the chromosome remodeling complex SWI/SNF subunit ARID1A were first identified in ovarian clear-cell carcinoma and ovarian endometrioid carcinoma, two endometriosis-associated epithelial ovarian cancer subtypes. ARID1A gene mutations are also observed in deep ovarian and deep infiltrating endometriosis, atypical endometrial…
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Endometriosis involving the Sacral Plexus and Sciatic Nerve
By Irem Onur
Endometriosis rarely involves the sacral and sciatic nerves. A retrospective analysis led by Rouen University Hospital, France and Aarhus University Hospital, Denmark, published in the Journal of Minimally Invasive Gynecology, has evaluated preoperative complaints, intraoperative findings, surgical procedures, and postoperative…
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Endometrioma size and anti-Müllerian hormone levels
By Hale Goksever Celik
Endometriotic lesions are encountered in different locations in the pelvic cavity, including but not limited to the ovaries, the pouch of Douglas, the ureters, the bladder, and the bowel. Cystic endometriosis lesions located in the ovary are called "endometrioma". Endometriomas have…
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Does hysterectomy bring a total relief in patients with endometriosis?
By Bahar Yuksel
There is a common belief that hysterectomy is the last option to relieve the pain in patients with endometriosis by stopping the production of menstrual material. The study entitled "Impact of hysterectomy on analgesic, psychoactive and neuroactive drug use in…
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By Murat OsmanPelvic MRI, Endometriosis and Radiologist
By Murat Osman
Endometriosis is a condition whereby ectopic endometrial cells implant themselves onto other structures within the body. Depending on where these lesions are, their size, and if they cause symptoms, surgical intervention may be warranted. Although the gold standard for diagnosing…
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How to unveil the discrepancy regarding the effect of chemicals on the etiology of endometriosis
By Nasuhi Engin Aydin
Kristen Upson from Michigan State University published a review article evaluating research papers on environmental factors effective in endometriosis from an epidemiological perspective in "Current Epidemiology Reports". Endometriosis is a multifactorial disease with anatomical, hormonal, immunological, estrogenic, genetic, epigenetic, and…
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Endometriosis and chronic opioid use
By Selma Oransay
The members of the American College of Obstetricians and Gynecologists have declared that gynecologists prescribe opioids after laparoscopic hysterectomy, or for relieving endometriosis pain, although guidelines are not available for when or how to use opioids for the treatment of endometriosis-associated…
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Adolescent endometriosis: Diagnostic clues?
By Irem Onur
The rates of dysmenorrhea, dyspareunia, and heavy menstrual bleeding in adolescents showing endometriosis signs on ultrasound are significantly higher compared to those without. This is according to a retrospective observational study recently published in the journal "Fertility and Sterility". The…
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Reduced risk of "small for gestational age baby" following frozen embryo transfer in endometriosis patients
By Hale Goksever Celik
Infertility is encountered frequently in patients with endometriosis. These women could be managed using assisted reproductive technology (ART) including in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) to achieve pregnancy. However, some adverse obstetric and perinatal outcomes are experienced more…
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Endometrial fluid analysis as a new diagnostic test for endometriosis diagnosis
By Bahar Yuksel
There is still a huge demand for finding a minimally invasive diagnostic test for endometriosis and yet none has been defined properly. The present study which was conducted in Cleveland Clinic by Natalia C. Llarena et al between March 2017…
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Comparison of diagnostic accuracy of imaging modalities for the deep infiltrating endometriosis
By Selma Oransay
The treatment of deeply infiltrated endometriosis (DIE) is usually personalized and the potential success for the available therapeutical options is dependent on early and accurate diagnosis. Laparoscopy is the gold standard for the diagnosis of DIE. Other non-invasive diagnostic methods…
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Endometriosis and adenomyosis could be the “sides of the same coin”.
By Nasuhi Engin Aydin
The two common gynecological disorders, namely adenomyosis, and endometriosis are not settled yet, whether they are representing two different entities or different phenotypes of the same ailment. Dr. Maruyama and colleagues from Nara, Japan searched PubMed and Google Scholar electronic…
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Endometriosis and Natural Killer Cell Immunity
By Dr. Youngran Park
It is known that approximately 25 to 50% of infertile women have endometriosis, and 30% to 50% of the women with endometriosis have infertility and recurrent pregnancy loss. Previous studies have shown that women suffering endometriosis have abnormal NK cell…
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Magnetic resonance imaging classification for the management of deep pelvic endometriosis
By Irem Onur
A new study published in the journal "Human Reproduction" reported that operating time, hospital stay, and postoperative complications in patients who underwent surgery for deep endometriosis can be predicted by the MRI. This result may be useful for clinicians to…
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By Timur SeckinCombination of noninvasive biomarkers in the identification of endometriosis
By Timur Seckin
The combined measurement of urine enolase, serum CA125, and CA19-9 may be an accurate test for the prediction and detection of endometriosis. This is according to a study published in the journal BioMedical Research International. The gold standard for the…
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Patients' opinion about surgical treatment of endometriosis
By Selma Oransay
Delayed diagnosis and management of endometriosis and chronic pelvic pain is a major problem in gynecologic practice. Alternatively, providers may feel reluctant to perform surgery although they are aware of treatment options and surgical timing. One possible reason for this…
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Segmental bowel resection could be predicted using MRI in patients with rectal endometriosis
By Hale Goksever Celik
The rectum and recto-sigmoid junction are the preferential localisations of bowel endometriosis. The three main surgical approaches are shaving, disc excision, and segmental resection. It is very important to decide the most appropriate surgical method preoperatively and to plan accordingly. …
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Can a grape ingredient, resveratrol, be the promised warrior to defeat endometriosis?
By Bahar Yuksel
Endometriosis is a chronic estrogen-dependent disorder and has a known relationship with angiogenesis, inflammation, and oxidative stress. Resveratrol is a part of a "polyphenol" compound which are thought to act like antioxidants, protects the body against damage. This compound is normally…
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Dyspareunia and Endometriosis
By Irem Onur
Women experience severe pain during intercourse related to endometriosis and this has a significant negative impact on the lives of women. This is according to an American study published in the "Journal of Pain Research". The study included 638 endometriosis…
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Bad bad lipid go away!
By Yu Yu
Much like the progression of endometriosis, accumulating evidence suggests that systemic chronic inflammation and oxidative stress can contribute to atherosclerosis. The excess low-density lipoprotein increases inflammatory processes in the arteries, which may result in atherosclerosis. Previous studies have shown that…
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Indocyanine green in endometriosis surgery
By Selma Oransay
Recently, indocyanine green is well studied and used safely in real-time perfusion to organs or tissues, after taking into consideration its binding capacity to the plasma proteins. The usefulness and the effectiveness of near-infrared camera guided indocyanine green is proved with…
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Osteopontin and Endometriosis
By Dr. Youngran Park
Although characterized as a benign disease, some properties of endometriosis mimic malignant tissues such as proliferation, cell invasion, and metastasis. Osteopontin, also called secreted phosphoprotein 1, is one of the important molecular targets in cancer progression and metastasis. Osteopontin has been…
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It is time for non-invasive tests for peritoneal endometriosis diagnosis
By Nasuhi Engin Aydin
Maria Szubert with colleagues from Lodz Medical University, Poland, investigated the possibility of potential diagnostic biomarkers in the eutopic endometrial tissue from peritoneal endometriosis patients and published their results in the "Journal of Gynecology Obstetrics and Human Reproduction". Currently, diagnostic…
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Psychometric properties of Endometriosis Health survey-Swedish version
By Hale Goksever Celik
Endometriosis is a chronic estrogen-dependent disease resulting in a broad spectrum of symptoms and signs including dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Additionally, gastrointestinal and urinary systems may be affected by this disease. All of these clinical findings impair…
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Fallopian tube endometriosis
By Bahar Yuksel
Endometriosis affects various tissues including pelvic and extra-pelvic organs. Fallopian tube endometriosis is not a widely studied topic in endometriosis, hence the real incidence is unknown as not all studies evaluate microscopically diagnosed Fallopian tube endometriosis. In the retrospective database…
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Non-coding RNAs and Endometriosis
By Ellen Tumimbang
Non-coding RNAs may have a fundamental role in the development of endometriosis. Non-coding transcripts have regulatory roles in the expression of protein-coding genes, thus regulate several signaling pathways. Based on their length, these non-coding RNAs are classified into two main classes:…
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Body mass index, the incidence of endometriosis and the severity of dysmenorrhoea
By Timur Seckin
According to a case-control study conducted by researchers from China, there is no association between body mass index (BMI) and the incidence of endometriosis. This finding contrasts with the conventional knowledge that low BMI is a risk factor for endometriosis.…
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An animal model of endometriosis reveals stress related disturbed vitamin D - vitamin D receptor axis
By Nasuhi Engin Aydin
Lopez and colleagues from academic institutions of Puerto Rico published their experimental endometriosis findings on female rats regarding the effect of stress on vitamin D-vitamin D receptor systems and recently published their findings in "Reproductive Sciences". The group previously showed…
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The peculiarity of adolescent endometriosis
By Selma Oransay
Recent studies showed the prevalence of endometriosis in adolescents with chronic cyclic or acyclic pelvic pain is about 60-70%. Moreover, all stages of endometriosis, including deeply infiltrating endometriosis can be found in this population. Gubbels et al. from the Department…
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The intensity of pelvic pain is higher in endometriosis patients
By Irem Onur
Silva J.B. et al., researchers from Brazil, conducted a case-control study to determine the intensity of clinical pain, the average body composition, and the anthropometric markers including the body mass index, the perimeters (waist, abdomen, hip), and the percentage of…
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The more than expected prevalence of endometriosis in patients with Mullerian abnormalities
By Bahar Yuksel
Congenital müllerian anomalies resulting in a spectrum of uterine abnormalities are caused by the abnormal embryologic fusion of the müllerian ducts to form a normal uterine cavity. They are often unrecognized because they are usually asymptomatic. The presence of a uterine…
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Depression and anxiety levels in "in vitro fertilization" patients with endometriosis
By Hale Goksever Celik
Endometriosis is a reproductive-aged and estrogen-dependent disease. The most common symptoms of this disease are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility affecting the quality of life in several aspects mainly the psychological domain. In the literature, there are many studies…
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Endometriosis-related obstetrical complications and their outcome
By Selma Oransay
Borisova et al. from the Department of Gynecology and Obstetrics of Peoples' Friendship University, Moskow, Russia, and her colleagues from the Center of Perinatal and Reproductive Medicine of University Perugia, Italy, recently published a review of the literature data about…
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Time for reassessment : Laparoscopic surgery and bowel endometriosis
By Nasuhi Engin Aydin
Ferrero and associates from medical centers of Verona and Genoa, Italy, made a comprehensive review covering all aspects of the surgical approach to bowel endometriosis, published their results in "Best Practice & Research Clinical Obstetrics and Gynaecology". Bowel endometriosis is the…
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Cellular communications: Exosomes in Endometriosis
By Dr. Youngran Park
Exosomes have been reported as cell-to-cell communicators, transfer many molecules such as miRNAs, RNAs, and proteins, and their alteration may cause many disease processes, including endometriosis. Considering the role of exosomes and their cargos in a cell to cell communication as important…
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Predictors of voiding dysfunction after surgery for deep endometriosis
By Selma Oransay
While surgery for deep endometriosis provides relief and improves the quality of life in symptomatic patients for whom medical therapy has limited effect, it may also create postoperative lower urinary tract dysfunction. Moreover, postoperative voiding dysfunction could affect the quality…
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Sleep Quality, Lifestyle Factors and Endometriosis
By Hale Goksever Celik
Endometriosis does not only affect the patients by dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. An important issue in these patients, like other chronic diseases, is sleep quality. Youseflu et al., from Iran, published a study entitled “Effects of endometriosis…
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Colorectal Deep Endometriosis Resection and Potential Complications
By Murat Osman
A severe clinical form of endometriosis, deeply infiltrating endometriosis (DIE) is characterized by more aggressive endometriotic lesions commonly involving deeper pelvic or gastrointestinal organs. It causes significant quality of life impairment and morbidity and is increasingly associated with infertility. When…
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Factors affecting the quality of life of women with endometriosis
By Timur Seckin
Results from a new study suggest that the quality of life of women with endometriosis is significantly affected by their confidence to manage pain and their belief in the evolution of their condition. In this study, led by Rees M. et…
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Deep Endometriosis or Recto-uterine Obliteration Without Endometrioma
By Selma Oransay
The diagnostic help of ultrasound is increasing by its ability to diagnose deep infiltrating and rectouterine pouch obliteration in patients who are suffering from chronic pelvic pain. Clinicians are used to evaluating the rectal and parametrial areas of the endometriotic…
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Antioxidant Enzymes in Endometriosis
By Dr. Youngran Park
Recent attention has been focused on the effect of oxidative stress in the development of endometriosis. Especially, there are several studies regarding glutathione peroxidase (GPX), a major enzyme in removing various reactive oxygen species. In the field of infertility, the…
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The advantages of combined vaginal-laparoscopic approach on voiding dysfunction for rectovaginal endometriosis
By Irem Onur
The patients with rectovaginal endometriotic nodules with extensive vaginal infiltration who are managed combined vaginal-laparoscopic approach have a lower risk of postoperative bladder dysfunction when compared to surgery via laparoscopy alone. This is according to a manuscript published in the…
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Inhibiting killer on the move
By Yu Yu
The three main forms of endometriosis are superficial, ovarian, and deep endometriosis. The latter is defined by the presence of endometriotic nodules that are deeper than 5 mm. Deep endometriosis is considered the most aggressive and is associated with severe…
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Endometrial polyps of patients with and without endometriosis
By Nasuhi Engin Aydin
Endometrial polyps are benign local overgrowths comprising both glands and the stroma, and are quite common in gynecological practice. Endometriosis patients also commonly have polyps, which have yielded different features than those from patients without endometriosis. Dr. Jiangand and associates…
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The impact of laser vaporization on reproductive outcomes in women with endometrioma
By Hale Goksever Celik
Despite extensive research, the optimal method for the management of endometriosis still remains unclear. Excisional surgery is claimed with a more favorable outcome than drainage and ablation regarding the recurrence of disease and symptoms. On the other hand, cyst vaporization…
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A Call for Pan-Canadian Collaboration for the Care and Quality of Life of Endometriosis Patients
By Timur Seckin
Wahl KJ et al., from Canada, drew attention to the lack of health care for endometriosis patients who are estimated to be 1 million in number in Canada in their recent brief communication report. The delay in the diagnosis, the…
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Bowel surgery for endometriosis
By Dr. Youngran Park
Endometriosis is an estrogen-dependent disorder. The disease harbors various complications. Deep endometriosis involving the bowel is only one aspect of the condition that has variable phenotypic presentations and pathologic subtypes. Knowledge of the short- and long-term risks of the surgical…
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Benefits of Nerve-Sparing Hysterectomy
By Selma Oransay
The retroperitoneal spread of endometriosis or cancer may involve pelvic autonomic nerves situated on the lateral aspects of uterosacral ligaments, vesicouterine ligaments, and medial aspects of parametria. During the conventional open hysterectomy operations, nerve-sparing excision is very difficult, simply because pelvic autonomic nerves…
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Mental stress promotes mice endometriosis
By Bahar Yuksel
Endometriosis is a disease for which pathogenesis and progression are not fully understood. Inflammation is one of the key candidates that might be related to the creation or progression of endometriosis. In the study conducted by Kawakita et al from…
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Diagnosis and treatment of endometriosis in adolescents
By Irem Onur
The belief that dysmenorrhea, the primary symptom of endometriosis, in adolescents is an inevitable condition seen in menstruation as well as unwillingness to perform diagnostic laparoscopy may cause the delay of diagnosis of endometriosis. This is according to a recent…
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Natural history of spontaneous endometriosis in crab-eating monkeys
By Nasuhi Engin Aydin
Kaori Hayashi and associates from Shiga University of Medical Science, Japan, published their observations on spontaneously occurring endometriosis in crab-eating monkeys in "Tohoku Journal of Experimental Medicine"https://www.jstage.jst.go.jp/article/tjem/251/4/251_241/_pdf/-char/en. The presence of endometrial tissue outside the uterus, i.e., endometriosis is a progressive prevalent…
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Is there a commonality between endometriosis and systemic lupus?
By Murat Osman
Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect many organs including the skin, joints, the central nervous system, and the kidneys. Women of childbearing age and certain racial groups are at increased risk to develop the condition.…
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Patient-centered care in patients with endometriosis
By Hale Goksever Celik
The women with endometriosis suffer from several symptoms and signs including dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility which have a detrimental effect on their quality of life. Endometriosis is diagnosed with 7-10 years of delay due to the absence…
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Immune cells and endometriosis pain
By Dr. Youngran Park
Endometriosis is an estrogen-dependent inflammatory disorder in women. This disease leads to dysmenorrhea, pelvic pain, and infertility. The immune reaction is one of the most widely accepted pathologies of endometriosis. Estrogen dysfunction stimulates immune cells in the peritoneal cavity affecting…
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Voiding Dysfunction after Colorectal Surgery for Endometriosis
By Timur Seckin
Postoperative voiding dysfunction is a less frequent complication of rectal shaving than that of discoid excision or segmental resection in patients undergoing colorectal surgery for endometriosis, regardless of its definition. This is according to a meta-analysis conducted by researchers from…
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Prevalence, Risk factors and Management of Bowel Fistula after Rectosigmoid Surgery for Deep Endometriosis
By Selma Oransay
Bowel fistula is a severe complication after the colorectal endometriosis surgery, but little is known about its prevalence, and reports on large series are lacking. To discuss specific management on colorectal deep endometriosis, Roman et al. conducted a retrospective study…
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Endometriosis prevalence among adolescents with pelvic pain
By Irem Onur
An updated review conducted by the investigators at EGA Institute for Women's Health, University College London, United Kingdom, in collaboration with Birmingham Women’s and Children’s Foundation Trust of the Institute of Metabolism and Systems Research at the University of Birmingham…
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Reproductive capacity and recurrence rate after surgery for Stage III/IV endometriosis
By Bahar Yuksel
If gaining fertility back is the main goal, the surgical removal of endometriosis lesions is globally recognized as first-line therapy. Even though, pre- and postoperative hormone therapy leads to a significant decrease in the spread of the disease measured with the…
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The effects of nutrients on endometriosis-related symptoms
By Nasuhi Engin Aydin
A recent literature review from the Netherlands by researchers Emma Huijs and Annamiek Nap, published in "Reproductive Biomedicine Online" puts light on the effects of some nutrients for endometriosis-related symptomatology. Endometriosis has heterogeneous pathogenesis involving genetic, immunological, environmental, and hormonal…
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Early maternal separation and endometriosis progression in adult mice
By Hale Goksever Celik
The quality of life in the women affected by endometriosis depends on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Although several studies have been performed to investigate the underlying pathophysiologic mechanism, it…
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Increased expression of epithelial cell adhesion molecule and its possible role in epithelial-mesenchymal transition in endometriosis.
By Dr. Youngran Park
Endometriosis is an estrogen-dependent disease that functional endometrial tissue exists outside both the uterine cavity and myometrium. The pathogenesis of endometriosis remains unclear and controversial. According to the implantation theory, which is the most well-known, migration and invasion are two…
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Fallopian tubes and endometriosis
By Selma Oransay
There are multiple theories to explain the pathogenesis of endometriosis, among which the most popular one is Sampson's retrograde menstruation theory. The role of endometrial stem cells/progenitors are widely studied to support the origin of ectopic lesions in recent decades.…
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Hormone Control Related Genes in Women With Endometriosis
By Ellen Tumimbang
Endometriosis is an estrogen-dependent disease. The development of endometriosis is stimulated by the specific ability to receive the estrogen that is needed for growth and differentiation of endometrial cells and has numerous biological functions in eutopic and ectopic endometrium. Estrogen…
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Endometriosis Impacts Transgender Adolescents
By Irem Onur
Shim J.Y. et al, from Boston, Massachusetts retrospectively searched the electronic medical records of transmasculine patients younger than 26 years old who were diagnosed with dysmenorrhea and treated at Boston Children’s Hospital, between January 1, 2000, and March 1, 2020.…
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By Nadire DuruClinical characteristics linked to recurrence of ovarian endometrioma
By Nadire Duru
Endometriosis affects 10-15% of women. Three types of endometriosis are peritoneal, ovarian, and deep infiltrating endometriosis. Ovarian endometriosis is the most common type of endometriosis with a high rate of recurrence. Laparoscopy is the gold standard treatment for endometriosis and…
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The impact of obesity on safety and feasibility of laparoscopic endometriosis surgery
By Hale Goksever Celik
The quality of life in the women affected by endometriosis depends on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. The most common locations of endometriosis are ovary, ovarian fossa, uterosacral ligament, and…
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Adolescent endometriosis
By Timur Seckin
A recent article, led by experts from Peking Medical Union College, describes the clinical characteristics and postoperative symptoms of adolescent endometriosis. The authors inform that their report, which is published in the "Journal of Pediatric and Adolescent Gynecology", can provide…
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Suggested remedies for endometriosis patients during coronavirus pandemic
By Nasuhi Engin Aydin
The pandemic of COVID-19 continues to have important effects on endometriosis patients worldwide. Many health care facilities stopped providing surgical management and outpatient appointments are canceled or postponed. Dr. Leonardi from Australia and associates from several countries published their proposals…
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Hysterectomy as a choise of chronic pelvic pain relief in endometriotic women.
By Selma Oransay
Sandstrom et al. from the Department of Obstetrics and Gynecology of Umea University, Sweden, found a significant and long-lasting reduction in pain symptoms after hysterectomy among women with confirmed endometriosis and recently published their results in "BJOG". The authors performed…
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Occult microscopic endometriosis in clinically negative peritoneum
By Irem Onur
Occult microscopic endometriosis may be present in approximately 39% of patients with clinically negative appearing peritoneum undergoing laparoscopy for chronic pelvic pain. This finding is presented in a study published online this month in the International Journal of Gynecology &…
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Adolescent dysmenorrhea diagnosis and management
By Hale Goksever Celik
Endometriosis is usually diagnosed in reproductive-aged women. However, recent literature proved that clinical symptoms of endometriosis are also seen the adolescent girls and young women. Dysmenorrhea, the most common gynecologic complaint among this age group, can develop due to endometriosis.…
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Bone morphogenetic protein and endometriosis
By Nadire Duru
Endometriosis is a chronic disease characterized by the presence of endometrial glands and stroma outside the uterus, associated with several discomforts such as pelvic pain, menstrual disorders, and infertility. Although endometriosis is categorized as a benign lesion, the ectopic endometrial…
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Local inflammation and follicle development in women with ovarian endometriosis
By Dr. Youngran Park
Endometriosis, a cause of subfertility, is found in almost 50% of infertile women. The elevated levels of cytokines in the follicular fluid of patients with endometriosis might account for the ovulatory dysfunction. Granulosa cells (GCs) play important roles in follicular…
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Anogenital distance and endometriosis
By Timur Seckin
Endometriosis may be associated with exposure of the embryo to chemicals called ‘endocrine disruptors’. Exposure to endocrine disruptors can be estimated by measuring the anogenital distance (i.e. the distance between the clitoris and the anus), using a centimeter ruler with…
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International experts commentary for assisted fertility treatment facilities amidst COVID-19
By Nasuhi Engin Aydin
A multinational and multi-institutional commentary led by Dr. Alviggi from Italy and Dr.Esteves from Brazil has addressed important issues on assisted reproductive technology treatment amid COVID-19 lockdown suggesting remedies in the journal of "Reproductive Biology and Endocrinology" May 2020 issue.…
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The effect of endometriosis on the quality of life
By Hale Goksever Celik
Endometriosis, the disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity, can be diagnosed in the reproductive-aged women with an incidence of 7-15%. However, endometriosis is observed in women with chronic pelvic pain syndrome…
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Endometriosis Diagnosis in White, Black, and Asian Women
By Özge Özkaya
In a commentary published in the "International Journal of Obstetrics and Gynaecology", Drs. Farland and Horne talk about a study by researchers in Canada and the Philippines, which found that black women are less likely, and Asian women are more likely to…
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Diagnosing Deep Endometriosis Using Transvaginal Elastosonography
By Murat Osman
Deeply infiltrating endometriosis (DIE) is an advanced form of endometriosis that causes significant morbidity to a large number of women. Early detection of endometriosis is imperative for early treatment and improved outcomes for these patients. Currently, transvaginal ultrasound (TVUS) and magnetic…
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Menstrual Blood Proteins for Endometriosis Diagnosis
By Ellen Tumimbang
Endometriosis is a gynecological disorder characterized by endometrial tissue outside the uterine cavity. The backflow of menstrual blood from the uterus through the fallopian tubes is thought to be the cause of endometrial tissue growing outside the uterine cavity when…
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A hope for postoperative symptomatic endometriosis therapy
By Irem Onur
A new chapter in the treatment of symptomatic endometriosis patients may begin since new medical approaches including oral GnRH antagonists, selective progesterone receptor modulators, aromatase inhibitors, and peritoneal immune response modulators are being actively evaluated. To date, there was only…
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Opioids use in women with endometriosis, what does it tell us?
By Yu Yu
Endometriosis is a debilitating disease that can cause many painful symptoms such as dysmenorrhea, dyspareunia, infertility, chronic pelvic pain, abdominal pain, and sacral or low back pain. More than half of women diagnosed with endometriosis suffer from chronic pelvic pain.…
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Diagnosis and treatment algorithm for endometriosis
By Selma Oransay
Endometriosis is a chronic and progressive disease that affects 25-30% of women between 25-35years, clinicians commonly experience during their gynecologic practice. However, the diagnosis is still late or sometimes incorrect, and this creates severe health problems and worse outcomes. A…
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Endometriosis by Race
By Hale Goksever Celik
Endometriosis is usually diagnosed in reproductive-aged women with an incidence of approximately 10%. The most common presenting symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility in patients with endometriosis. Some risk factors have been identified for the development of…
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Health inequalities in USA
By Timur Seckin
Dr. E. Albert Reece, the vice president for medical affairs at the University of Maryland, Baltimore, specialized in maternal and fetal medicine, wrote on health disparities in the American nation, in Obstetrics and Gynecology News, on the website www.mdedge.com, in June…
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Discrepancies between racial/ethnic groups and choice of hysterectomy procedures
By Nasuhi Engin Aydin
Dr. Pollack and associates from Washington University, St.Louis, made multistate research regarding the patient profile in hysterectomies and published their results in the 2019 December issue of "The Journal of Minimally Invasive Gynecology". The most frequently performed nonobstetric surgery in…
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Is oocyte cryopreservation useful for fertility preservation in ovarian endometriosis?
By Irem Onur
Women with endometriosis tend to have lower fecundity compared to normal couples. Furthermore, endometrioma itself may reduce the ovarian reserve by altering ovarian physiology in the surrounding healthy ovarian tissue. The treatment for endometrioma is surgical removal in most cases, however,…
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How Can Racial and Ethnic Disparities Be Reduced Among Women’s Health and Healthcare?
By Özge Özkaya
The American College of Obstetricians and Gynecologists published a set of recommendations to help reduce racial and ethnic disparities in women’s health and healthcare and encourage obstetricians, gynecologists, and other health care practitioners to engage in activities to help achieve…
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Endometriosis surgery and future pregnancy complications
By Selma Oransay
Endometriosis is one of the known diseases for infertility in the reproductive period of women. Several studies revealed that endometriosis itself maybe the reason for some unfavorable obstetric outcomes. Localization, the type of endometriotic lesions, and the stage of endometriosis…
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Case-control study to develop a questionnaire for early diagnosis of endometriosis
By Nadire Duru
Endometriosis, which affects 5–10% of women of reproductive age, is a chronic gynecological disease characterized by the presence of endometrial glands and stroma outside the uterus, associated with several discomforts such as pelvic pain, menstrual disorders, and infertility. Ultrasound evaluation…
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The predictors for sexual dysfunction in infertile women with endometriosis
By Hale Goksever Celik
Endometriosis is a disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. Its incidence ranges up to 10% of reproductive-aged women. The most common symptoms in these women are chronic pelvic pain, dyspareunia, and…
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Immune System, Cytokines and Endometriosis
By Dr. Youngran Park
Endometriosis is an estrogen-dependent chronic disease. Diagnosing endometriosis is difficult because the signs and symptoms vary considerably. Therefore, the discovery of a reliable non-invasive diagnostic biomarker would represent a major advance for the clinical diagnosis of endometriosis. It has been…
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Neglected needs of endometriosis and infertility patients during COVID-19 pandemic
By Timur Seckin
With the global outbreak of the COVID-19, hospitals canceled surgeries and people are afraid of going to hospitals. However, chronic diseases still need to be managed. Rowe H. and Quinlivan J., researchers from Australia, pointed out the neglected needs of…
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Risk Factors Associated with Ureteral Endometriosis
By Özge Özkaya
Patients with severe endometriosis, uterosacral ligament deep involvement with endometriosis lesions of 3 cm in diameter or more, and the presence of previous endometriosis surgery have a significantly higher risk of having ureteral endometriosis. This is according to a study…
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Resveratrol for infertility: A frenemy?
By Selma Oransay
Ovarian aging is defined by an age-specific decline of the functional ovarian reserve. Female ovarian reserve declines progressively with increasing chronological age. Chronic damage by reactive oxygen species results in deterioration and aging through mitochondrial dysfunction, telomere shortening, cohesion dysfunction,…
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Fatigue from the viewpoint of patients with endometriosis
By Irem Onur
Fatigue, feeling spoonie, is documented as a significant symptom of endometriosis in many studies. Researchers from three different institutions dealing with reproductive health conducted individual interviews with patients reporting moderate to severe endometriosis-related pain to better understand endometriosis-related fatigue and…
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Postmenopausal endometriosis: Is it a rare phenomenon?
By Hale Goksever Celik
Endometriosis, the estrogen-dependent disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity, is generally diagnosed in the reproductive-aged women. However, recent literature proved that this disease can also be observed in the premenopausal and…
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NAT2 as potential biomarker for the diagnosis and treatment of endometriosis
By Nadire Duru
Endometriosis affects 5–10% of women of reproductive age causing several discomforts, pelvic pain, menstrual disorders, ectopic bleeding, infertility, and sometimes even malignant transformation but its etiology remains unclear. Accumulating evidence point a key role for genetic factors and there is…
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miR-92a and progesterone resistance in endometriosis
By Dr. Youngran Park
Endometriosis is an estrogen-dependent disorder. This incidence of this disease is 35% to 50% among those who suffer from chronic pelvic pain and infertility, which has a negative effect on the quality of life and on health. Recent genome-wide associations…
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Endometriosis and Insomnia
By Timur Seckin
There should be more awareness among clinicians for the relationship between insomnia and endometriosis, the study suggests. There needs to be a suspect of endometriosis whenever the clinician faces women of reproductive age with sleep or insomnia-related symptoms. This symptom is…
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Progressive nature of ovarian endometrioma
By Yu Yu
The effective management of endometriosis requires a proper understanding of how the condition progress as women age, especially for those women with early onset of endometriosis. Several studies have tried to characterize the evolution of endometriosis. Some of the key…
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Improved fusion imaging for the detection of Endometriosis
By Murat Osman
This paper studied a new fusion method for magnetic resonance (MR) and ultrasound (US) imaging for the appropriate diagnosis of endometriosis. The diagnosis of endometriosis in patients with a chronic pelvic disease is delayed, due to the disease, patient, and physician-led…
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Appendiceal endometriosis
By Selma Oransay
Jeong et al. from the Departement of Surgery, Trinity School of Medicine, Saint Vincent, recently published their interesting appendectomy case in "Hong Kong Medical Journal". In their case, endometriosis inside the cavity of the appendix mimicked appendicitis, the patient submitted…
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Defective “ferroptosis”: a new pathogenetic explanation of endometriosis
By Nasuhi Engin Aydin
Dr. Ng and associates from Tufts University School of Medicine, Boston, USA made a comprehensive review of the role of the iron element in the development of endometriotic lesions. Though iron element is essential for cell survival, and its deficiency is important…
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Are endometriosis patients at higher risk of bipolar disorder?
By Irem Onur
Endometriosis patients are prone to develop certain psychiatric disorders, including depression and anxiety, as well as bipolar disorder, according to a nationwide population-based cohort study from Taiwan. Bipolar disorder formerly called manic-depression is a chronic mental disorder characterized by unusual changes…
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Maternal body mass index and neonatal outcomes in women with endometriosis
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal-like tissue outside the uterine cavity. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of…
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Interleukin-37b inhibits the growth of murine endometriosis-like lesions
By Nadire Duru
Endometriosis is a chronic gynecological disease that causes chronic pain and infertility in women. Despite continuous efforts and numerous research, there is, ultimately, still much to understand about the pathogenesis of endometriosis. Inflammatory factors including several interleukins have already been…
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Hysterolaparoscopy Plus Assisted Reproduction Improves Fertility in Women with Endometriosis
By Özge Özkaya
Hysteroscopy and laparoscopic surgery is an effective and reliable therapeutic procedure, confirmed a study published in the "Journal of Clinical Medicine". The approach is even more effective when combined with assisted reproductive techniques such as artificial insemination and in vitro…
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By Yohan SuryoSteroid hormone receptors in endometriosis
By Yohan Suryo
Therapeutics that target the steroid hormones are the standard treatment for women with endometriosis because steroid hormones play an important role in endometrial physiology and pathogenesis of endometriosis. Examples of these therapeutics include anti-estrogens, estrogen receptor (ER) modulators, progestins, and…
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How should MRI images be obtained for optimal endometriosis detection?
By Murat Osman
It is well known that the diagnosis of endometriosis for some patients with the chronic pelvic disease is delayed, often for years, due to the disease, patient, and physician-led factors. An area of active study is how ordering physicians can…
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Transvaginal sonography for predicting the distance between rectosigmoid endometriosis and the anal verge
By Timur Seckin
For optimal surgery, pre-surgical assessment of the distance between rectosigmoid deep endometriosis lesions and the anal verge (Lesion to Anal Verge Distance-LAVD) is recommended by many specialists. A group of researchers from Norway, Austria, and Australia studied the accuracy of…
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Oxidative stress leads to elevated cytokines, excessive structural damage and angiogenesis
By Yu Yu
Endometriosis is characterized by elevated intracellular reactive oxygen species, which is then believed to upregulate inflammatory cytokines. Reactive oxygen species also regulate the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which is closely linked with immune responses.…
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Surgical approach to rectovaginal endometriosis.
By Selma Oransay
Recto-vaginal endometriosis incidence is estimated at 3.8%-37% among women with endometriosis and when it exists it's a part of deeply infiltrated endometriosis, thus advance stage endometriosis. Raimondo et al. from the Department of Obstetrics and Gynecology of the University of…
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tRNA-derived fragments in ovarian endometriosis?
By Dr. Youngran Park
Endometriosis is an estrogen-dependent mysterious disorder characterized by the presence of endometrium outside the normal location of the uterus cavity. This disease affects approximately 10% of reproductive-aged women and becomes a major reason for infertility in reproductive-aged women and dysmenorrhea…
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Recurrence following surgery for subtypes of endometriosis
By Hale Goksever Celik
Endometriosis is a disease identified by the location of endometrial stromal and glandular cells outside the uterine cavity. It is considered as a gynecological disease of reproductive-aged women. Three subtypes of endometriosis are peritoneal endometriosis which defines the endometriotic lesions…
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The efficacy of combined hormonal contraception on pelvic pain in endometriosis patients
By Irem Onur
Chronic pelvic pain, which is experienced by more than 33% of endometriosis patients, constitutes a significant challenge for patients and physicians. A new study that appears in the journal Human Reproduction Open has explored the prevalence of endometriosis patients with a history…
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Antioxidants inhibit autophagy in ectopic endometrial cells
By Nadire Duru
Factors involved in the development of ectopic endometrium are not well-known, but several reports demonstrate a potential role for the pathophysiological processes including autophagy. Studies show that autophagy plays a significant role in endometriosis but the key mechanisms underlying the…
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A Routine Pelvic Ultrasound Examination Should Include an Evaluation for Endometriosis
By Özge Özkaya
Routine pelvic ultrasound examination should be extended beyond the uterus and ovaries into the posterior and anterior pelvic compartments, according to Australian doctors. With such examinations, deep infiltrating endometriosis nodules can be searched, say the authors, allowing women to be…
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Fertility conservation in women with endometriosis
By Selma Oransay
Endometriosis affects 10-15% of women in their reproductive period and almost half of them may need Assisted Reproductive techniques to conceive. Moreover, increased malignancy risk is threatening the women with severe endometriosis in addition to their decreased ovarian reserve. Due…
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Imaging of gastrointestinal endometriosis
By Murat Osman
Endometriosis is a disease characterized by the ectopic implantation of endometrial tissue to surrounding pelvic and extra-pelvic structures. One frequent site of involvement is the gastrointestinal(GI) tract, which occurs especially among women with deep infiltrating endometriosis. Most cases of GI-involving…
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Fertility preservation protocols in women with endometriosis
By Hale Goksever Celik
Infertility is one of the major symptoms in women with endometriosis. Childbearing at a delayed age is preferred by the majority of women recently who consult for the demand for fertility preservation procedures. There are several techniques for fertility preservation…
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Urgent Need For Building Resilience
By Timur Seckin
According to Naeem et al.’s article, “Coping with Covid”, Cognitive Behavioral Therapy (CBT) is the ideal intervention tool to increase resilience. Their study has recently been published in "Kyber Medical University Journal". The authors investigate the psychological impact of the Covid-19…
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Early Life Factors for Endometriosis
By Dr. Youngran Park
Endometriosis affects approximately 10% of reproductive-aged women. Despite the significant impact, the etiology of endometriosis is still unclear. A recent systematic review of 15 studies of adolescents found that overall 65% of girls undergoing laparoscopic investigation were diagnosed with endometriosis.…
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Long-term Pregnancy Results after Surgical Removal of Endometrioma
By Irem Onur
Sun et al., from China, investigated the pregnancy outcomes and the related factors in patients with endometrioma and stage III-IV endometriosis along with a long-term follow-up postoperatively. Their study has recently been published in the journal named "Advances in Therapy".…
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The Relationship Between Dyspareunia and Infertility in Endometriosis
By Selma Oransay
Wahl et al. from the Center of Pelvic Pain and Endometriosis British Columbia Women's Hospital, Vancouver, Canada studied with endometriotic patients suffering from dyspareunia who were referred to their center and built a cross-sectional study to investigate the relations between…
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All aspects of endometriosis reviewed with focus on modern management
By Nasuhi Engin Aydin
Dr. Chapron and associates from academic centers in France published in Nature Review Endocrinology, a comprehensive review on endometriosis. The article is inclusive of all aspects of endometriosis but especially focuses on the management of the disease with its contemporary status. Having a…
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Abdominal wall endometriosis: Who is at risk and what causes it?
By Murat Osman
Endometriosis is a condition that can cause anatomic, hormonal, and inflammatory disturbances that may ultimately result in decreased fertility or infertility. It is a disease process that is defined as ectopic endometrial-like tissue implanting itself to various pelvic and extra…
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Polymorphisms and endometriosis: a systematic review and meta-analyses.
By Yohan Suryo
The symptoms of endometriosis are varied among women and include chronic pelvic pain, infertility, and fatigue. There are no reliable blood tests and medical imaging techniques such as MRI and ultrasound are not always satisfactory. The lack of endometriosis-specific symptoms…
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Does Getting Pregnant Really Help When You Have Endometriosis?
By Özge Özkaya
Pregnancy has a favorable impact on the volume of deep infiltrating endometriosis lesions according to a study published in the scientific journal "PLoS One". This is the first study that demonstrates such a favorable impact of pregnancy on endometriosis lesion…
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Kisspeptin and its Receptor in the Pathogenesis of Endometriosis
By Irem Onur
It is known that matrix metalloproteinases (MMP) may play a role in the pathogenesis of endometriosis. For example, the upregulation of MMP-2 and MMP-9 may enhance the degradation of extracellular matrix proteins, facilitating cell migration and invasion. Kisspeptin (KISS1, also…
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The predictive factors for early spontaneous miscarriage in IVF/ICSI cycles
By Hale Goksever Celik
The most common presenting complaints of endometriosis are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Affected women demand therapy for these symptoms of endometriosis, notably fertility problems. The clinical pregnancy rate has increased up to 60% in assisted reproductive…
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Regulation of Inflammation in Endometriosis
By Dr. Youngran Park
Endometriosis is an estrogen-dependent and multifaceted gynecological condition. Unfortunately, this disease frequently causes chronic and cyclic pelvic pain. Though there are several treatments are available, there is not an actual cure for this disease. Therefore, the development of new therapy…
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Diaphragmatic endometriosis
By Selma Oransay
Diaphragmatic endometriosis is a rare clinical condition that may show signs and symptoms like chest pain, right upper quadrant abdominal pain, shoulder pain, pleuritic pain, hemothorax, pneumothorax, hemoptysis, and thoracic endometriosis syndrome while the major part of the patients is…
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Leiomyomas have similar genetic background with endometriosis
By Nasuhi Engin Aydin
This multicenter research conducted in institutions located in the USA and UK published in Nature Communications, October 2019 issue. Leiomyomata of the uterus are hormone-dependent tumors with an estimated prevalence of about 20-77%. İn several publications. Research in uterine leiomyoma…
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Cycle-related gastrointestinal complaints in reproductive age young women
By Timur Seckin
An analysis of 1-year data on 266 patients who presented to the Clinic and Polyclinic for Gynecology and Reproductive Medicine at Jena University Hospital to undergo surgery for endometriosis and its symptoms was performed by Nicolaous K. et al., a…
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Clinical Evaluation of Endometriosis-Associated Pain
By Nadire Duru
Endometriosis has a noteworthy impact on the quality of life of the patients diagnosed with it since it is associated with unpleasant conditions such as endometriosis-associated pain. The diagnosis of endometriosis is not always straightforward because of the varying symptoms…
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The relationship of serum concentrations of neuropilin-1 (NRP-1) and endometriosis
By Irem Onur
Although many serum biomarkers or biomarker panels for endometriosis are evaluated, none of them is exact enough to be used in daily laboratory practice. In a recent study, which has been published in Scandinavian Journal Of Clinical and Laboratory Investigation, Barberic…
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The genetic mutations in uterine adenomyosis
By Hale Goksever Celik
Adenomyosis is defined as the localization of endometrial stromal and glandular cells in the myometrium. This disease is a reproductive-aged women disease, like endometriosis. Additionally, adenomyosis is frequently observed together with endometriosis and leiomyomas due to common histological features and…
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By Demet Candaş GreenHow well do providers understand endometriosis?
By Demet Candaş Green
Endometriosis is a challenging disease no matter what side of the equation you are in, a patient or a provider who cares for patients with the disease. It impacts millions of women worldwide, making it one of the most prevalent…
Key Points Lay Summary
Phytotherapy as an alternative endometriosis treatment
By Dr. Youngran Park
Endometriosis is an estrogen-dependent gynecological disease that affects 5–10% of women in fertile age. Different therapeutic strategies are available to treat this disease, such as surgery, hormonal therapies, and nonsteroidal anti-inflammatory drugs. Medical therapy usually consists of different hormonal drugs,…
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Adiposity, endometriosis type and severity
By Selma Oransay
Dr. Jiyoung from the division of Public Health, Department of Family and Preventive Medicine of the University of Utah, planned a prospective cross-sectional study to assess whether there is an inverse relationship between the adiposity and endometriosis. The results of…
Key Points Lay Summary
The role of microbiota in the etiopathogenesis of endometriosis
By Hale Goksever Celik
Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. Although many advanced types of research about the etiology, differential diagnosis and treatment have been performed, it still remains an enigmatic disease. Dr. Bedaiwy, a scientist and physician…
Key Points Lay Summary
Integrated bioinformatic analysis for endometriosis diagnosis
By Nadire Duru
Endometriosis is considered as a non-malignant disease, but it is associated with several unfavorable conditions including non‑menstrual pelvic pain and infertility. Surgical resection and hormone suppression are common means of treatments; however, several side-effects and the recurrence are not preventable.…
Key Points Lay Summary
Preoperative serum CA 125 levels predict the severity of adhesions in endometriosis
By Irem Onur
Lee Y. et al., a group of researchers from Korea evaluated the correlation between preoperative serum markers and pelvic adhesions in endometriosis patients and explored the markers’ clinical value for outcome prediction. They have recently published their study in the…
Key Points Lay Summary
Which treatment option improves fertility the most?
By Murat Osman
Endometriosis is a condition that causes anatomic, hormonal, and inflammatory disturbances that may ultimately result in decreased fertility or infertility. It is estimated that 30-50% of women with endometriosis suffer from infertility. Thus, the role of surgical, medical, or expectant…
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Treatment choices for abdominal wall endometriosis
By Selma Oransay
Welch et.al, from the Department of Radiology, Mayo Clinic, Rochester, worked with his gynecologist colleagues to underline the current treatment algorithm of abdominal wall endometriosis in Mayo Clinic. Their experience results recently published in the journal "Abdominal Radiology". Abdominal wall…
Key Points Lay Summary
The role of acidic ribosomal protein P1 in Endometriosis
By Dr. Youngran Park
Endometriosis is an estrogen-dependent disorder. The disease develops and composed of the ectopic endometrial-like tissue which establishes primarily in the pelvic cavity. Previous findings clearly show that estrogen-related factors are critical for endometriosis development and progression. However, we do have…
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Woman at reproductive age suffering from migraines should consider getting evaluated for endometriosis.
By Demet Candaş Green
What do migraine and endometriosis have in common? One can easily answer “pain”. Turns out there are other shared aspects when it comes to these two conditions: both have a high prevalence in women of childbearing age, both suffer from…
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Rare lesions in the pathologic examinations of endometriosis.
By Selma Oransay
Dr. Glenn McCluggage from the Department of Pathology, Belfast Health, and Social Care Trust, penned a review about selected uncommon variants of endometriosis or benign alterations that may cause difficulties of pathologic diagnosis and provided all related histopathological illustrations in…
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A review of endometriosis in adolescent girls and young women
By Hale Goksever Celik
Endometriosis is an estrogen-dependent disease which is commonly diagnosed in reproductive-aged women. On the other hand, this disease can develop earlier in life due to different etiopathogenetic mechanisms. Especially adolescents who experienced neonatal uterine bleeding are under the risk for…
Key Points Lay Summary
Role of miR-141 in endometriosis
By Nadire Duru
MicroRNAs (miRNAs) are short (18–24 nucleotides) endogenous non-coding RNAs that regulate a broad range of signaling pathways. They bind to specific sequences resulting in mRNA degradation and protein inhibition. Deregulation of miRNAs is associated with the development of many disease…
Key Points Lay Summary
Impact of Genetic Variations in Endometriosis
By Dr. Youngran Park
Endometriosis is an estrogen-dependent disorder. This disease affects approximately 7% to 10% of reproductive-aged women and causes negative impacts on society. The underlying causes are unclear; therefore, the understanding of this disease remains a major clinical challenge. Endometriosis has a…
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The prevalence and severity of endometriosis today
By Irem Onur
Ghiasi M. et al., a group of researchers from the USA, presented a comprehensive review of the prevalence, incidence, and stage of endometriosis worldwide as reported over the past 30 years. Researchers performed a search in four databases, including PubMed,…
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Worrying signs of Endometriosis on Hysterosalpingography
By Murat Osman
Hysterosalpingography (HSG) is an imaging modality that utilizes fluoroscopy in order to evaluate the uterine cavity, fallopian tubes, and adjacent peritoneal cavity by injecting contrast media through the cervical canal. It is an important tool in the work-up of patients who…
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Endometriosis Severity and Complication Risks Following Laparoscopic Surgery
By Özge Özkaya
In a research article published in the journal Acta Obstetricia et Gynecologica Scandinavica, researchers at Brigham and Women's Hospital in Boston, Massachusetts suggested that the severity of endometriosis could not be a predictor of the risk of post-operative complications. In…
Key Points Lay Summary
The association between endometriosis and ectopic pregnancy
By Hale Goksever Celik
Endometriosis is a chronic inflammatory disease with a broad spectrum of symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain and fertility problems. It has been understood in the light of scientific evidence that endometriosis is also associated with other poor…
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What we should know in managing infertility related to endometriosis?
By Nasuhi Engin Aydin
Dr. Llarena and associates made a comprehensive review of the causes of infertility in endometriosis and adverse effects of surgical procedures in Clinical Medicine Insights: Reproductive Health. Infertility is an important issue in endometriosis patients and about 30-50 % face infertility.…
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Endometriosis and atherosclerotic cardiovascular disease
By Selma Oransay
Endometriosis and atherosclerotic cardiovascular disease show the same pathologic mechanism in terms of endothelial dysfunction. Tan et al. from the Department of Obstetrics and Gynecology, the University of British Columbia, Vancouver, Canada reviewed the literature aiming to determine whether women…
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CXCR4 or CXCR7 antagonists as novel therapies for endometriosis
By Dr. Youngran Park
Endometriosis is a common, estrogen-dependent chronic inflammatory disorder. It affects approximately 5-10% of reproductive-aged women and 20-50% of infertile women. Endometriosis also has a significant social and psychological impact on the lives of women. Despite such a significant burden, there…
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A nonhormonal treatment of endometriosis: Dichloroacetate
By Irem Onur
In women with endometriosis, peritoneal mesothelial cells show higher glycolysis, lower mitochondrial respiration, decreased enzymatic activity of pyruvate dehydrogenase and increased production of lactate compared to women without the disease. Transforming growth factorβ1 and lactate are elevated in the peritoneal…
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What do Women with Endometriosis Think About the Medical Profession?
By Özge Özkaya
Failure of surgical treatment, use of the emergency room, and access to complementary healthcare are factors associated with a negative perception of the medical profession in women with endometriosis. This is according to a study conducted by researchers in British…
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A comprehensive review on the etiopathogenesis of endometriosis
By Nasuhi Engin Aydin
Endometriosis, being a heterogeneous disease has a highly complex etiopathogenesis. A multicenter comprehensive review on this important subject from Italy, Germany, and the USA by Lagana and associates, was recently published in the "International Journal of Molecular Sciences" an open-access journal. Computerized…
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Endometriosis and ovarian reserve
By Hale Goksever Celik
Endometriosis is most frequently encountered in reproductive-aged women. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of 25-40%. Although the exact mechanism explaining the association between…
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How to design patient-centered interventions to meet the needs of endometriosis patients
By Selma Oransay
The treatment of endometriosis is not perfect and necessitates the development of patient-oriented care initiatives. On this basis, patient-related transparent information should be the priority for researchers to find out a way for targeted interventions. Steele et al. from Australia and…
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The Molecular Profile Unique to Endometriosis
By Murat Osman
Endometriosis remains to be a disease entity that is not fully understood. However, recent studies suggest that endometriosis is characterized by several dysregulated biochemical pathways that allow for its survival and growth outside the uterine endometrium. Authors have recently published…
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When to do - and when not to do surgery for endometriosis
By Dr. Youngran Park
Endometriosis is an estrogen-dependent disorder. It was estimated to affect about 176 million women in the world and usually causes pelvic pain and infertility. Unfortunately, the current understanding of this disease is very limited. Though there are many remaining questions,…
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Endometriosis in the Urinary Bladder
By Timur Seckin
A case of bladder endometriosis is reported by Geng JH, from Taiwan, and the paper has been recently published in The New England Journal Of Medicine. The patient was a 38-year-old woman presented to the outpatient urology clinic with complaints…
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Does the Severity of Endometriosis Increase the Risk of Complications Following Surgery?
By Özge Özkaya
The severity of endometriosis cannot predict the risk of complications after laparoscopy. Instead, the complexity of the surgical procedure itself may increase the risk of complications. This is according to a study published in the journal "Acta Obstetricia et Gynecologica Scandinavica".…
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A new ultrasound subgrouping reveals good clinical correlations in adenomyosis
By Nasuhi Engin Aydin
Exacoustos and colleagues from two endometriosis tertiary referral centers in Rome, Italy published their observational, prospective study of the recently proposed transvaginal ultrasonographic scoring system in the "Journal of Minimally Invasive Gynecology". Adenomyosis or “endometriosis interna” is defined as the…
Key Points Lay Summary
Recent advances in the diagnosis and treatment of endometriosis
By Hale Goksever Celik
Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. The most common complaints of women with endometriosis are pain and fertility problems. Although many advanced types of research about the etiology, differential diagnosis and treatment have been…
Key Points Lay Summary
Surgery and the endometriosis associated-pain: A systematic review
By Selma Oransay
The surgical approach for pelvic pain-related to endometriosis depends on the stage and the type of the endometriotic lesion and ranging from ablation and the excision of the lesions to radical surgery as hysterectomy with removal of ovaries and presacral…
Key Points Lay Summary
The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis
By Dr. Youngran Park
Endometriosis is a very common gynecological disorder affecting approximately 10% of reproductive-aged women, and it is known by the abnormal growth of endometrial stroma and glands outside the uterus. Though the pathogenesis of endometriosis is not clearly understood so far,…
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Post-menopausal women diagnosed with Endometriosis and "Imaging"
By Murat Osman
Postmenopausal endometriosis is an underrecognized clinical entity that may present similarly to those of younger patients with endometriosis. Radiologists have an important role in the diagnosis of these patients as they recommend which imaging study should be used to differentiate…
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Medical databases yield 32 published cases of surgically treated liver endometriosis
By Nasuhi Engin Aydin
Prodromidou and colleagues from Greece have published a review of surgically diagnosed, histopathologically proven liver endometriosis cases published worldwide, in the journal "Annals of Hepatology". Searching at three electronic medical databases namely, PubMed (1966–2019), Scopus(2004–2019), and Google Scholar (2004–2019) for…
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Hemorrhagic Ascites, Belly-Blood: The cause may be endometriosis!
By Timur Seckin
A paper on the presentation of hemorrhagic ascites in endometriosis patients, written by Bernard et al. from the United States and China, was published in the journal Fertility and Sterility. From 1978 to 2016, the authors found only 37 articles, which describe 42…
Key Points Lay Summary
Circulating Endometrial Cells
By Yu Yu
Endometriosis is difficult to diagnose because of non-specific symptoms. Currently, there is no biomarker that allows for non-invasive diagnosis of the condition. Surgical laparoscopy remains the standard for diagnosis. Circulating endometrial cells (CECs) is the lymphovascular spread of endometrial cells.…
Key Points Lay Summary
MRI findings predicting the need for colorectal surgical treatment of deep infiltrating endometriosis
By Irem Onur
LAY SUMMARY: Brusic A. et al., a group of researchers from Australia, conducted a retrospective study to identify the features of deep infiltrating endometriosis on MRI which have an association with colorectal surgical bowel resection. They have recently published their…
Key Points Lay Summary
Is deep infiltrating rectosigmoid endometriosis a progressive disease?
By Demet Candaş Green
This study by Netter at al., published in "Human Reproduction" in November 2019 aimed to assess the risk of progression of deep endometriotic nodules infiltrating the rectosigmoid and to evaluate the influence of continuous amenorrhoea (absence of menstruation) on the development…
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Regret assessment in women under 35 years who underwent hysterectomy
By Hale Goksever Celik
Hysterectomy is the most common gynecological operation in women for the management of benign or malign indications. Leiomyomas, menorrhagia, endometriosis, and pain unresponsive to medical treatment can be accepted as the most common indications for hysterectomy. However, hysterectomy, as the…
Key Points Lay Summary
Endometriosis features vs Patient age
By Dr. Youngran Park
Endometriosis, a common gynecological disease, has significant negative impacts on patients’ daily life. Especially in younger women who have yet to achieve pregnancy, effective management should consider the disease progression. Though it is still under debate, some people suggest that…
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Cannabis usage among Australian women with endometriosis
By Irem Onur
Sinclair J. et al., a group of researchers from Australia, conducted a cross-sectional online survey to determine the prevalence, tolerability, and self-reported effectiveness of cannabis in women with endometriosis. This study included 484 women with complete responses. Of all women,…
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Cloverleaf Sign: A new MRI sign for diagnosing DIE
By Selma Oransay
Magnetic resonance imaging provides accurate information for the staging of deeply infiltrating endometriosis, especially when the patient is virgin, obese or has limited transvaginal examinations due to pelvic pain. In this recently published study in Investive Radiology, Harma et al.…
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How Best to Assess Productivity at Work Among Women with Endometriosis?
By Özge Özkaya
The health-related productivity questionnaire (HRPQ) is a valid tool to evaluate patient-reported productivity at work and at home among women with endometriosis found a study by U.S. researchers. This finding is important because it shows that HRPQ can be used…
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Recurrent endometriosis is a real challenge both for the patients and clinicians
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Current medical and surgical treatment options have several limitations including the side effects, costs, risk of recurrence, effects on conception capability. Recurrence is a…
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Endometriosis and Insulin dependent Diabetes Mellitus
By Nasuhi Engin Aydin
Simmen and associates from the University of Arkansas for Medical Sciences, Alabama, published a review article about the co-existence of type 1 diabetes mellitus (T1DM) and endometriosis, in the recent issue of the "Journal of Endocrinology". Insulin-dependent diabetes or T1DM…
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A new target for the treatment of endometriosis?
By Dr. Youngran Park
Endometriosis affects around 10% of women in reproductive age, estimating more than 176 million women worldwide. Inflammation in the pelvic cavity is very common in endometriosis patients. Therefore, there are high concentrations of cytokines and immune cells in the peritoneal…
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Factors affecting risk of ovarian endometriosis malignancy
By Özge Özkaya
Getting married when older, having had ovarian endometriosis for longer, giving birth in a shorter time, and other complications in the uterus that are benign may all increase the risk of ovarian endometriosis malignancy. This is according to a study…
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The effect of endometriosis on implantation in women with endometriosis associated infertility
By Hale Goksever Celik
One of the most common clinical findings of women with endometriosis is fertility problems. Women with endometriosis often benefit from in vitro fertilization methods to get pregnant. However, whether there is a detrimental effect of endometriosis on in vitro fertilization outcomes…
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A rigorous literature review on endometriosis
By Irem Onur
Bulun SE. et al., from Feinberg School of Medicine, Northwestern University, Chicago, conducted a rigorous literature review on endometriosis. This outstanding review by Dr. Bulun et al. addresses the definition, remarkable medical features, clinically useful research findings, prevalence and distribution,…
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Thoracic endometriosis: the most frequent endometriosis involvement outside abdominopelvic cavity
By Nasuhi Engin Aydin
Six to ten percent of reproductive-age women are affected by endometriosis, and about 12% are estimated to be outside the abdominopelvic cavity - the most frequent location being the thorax. Endometriosis within the pulmonary parenchyma or on the diaphragm and…
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Machine Learning Classifiers for Endometriosis
By Dr. Youngran Park
Endometriosis is a complicated gynecological disorder that affects about 176 million women worldwide. It significantly impairs mental and physical quality of life in patients but the etiology is poorly understood. Endometriosis also causes a large economic burden due to loss…
Key Points Lay Summary
Transvaginal Ultrasound of Endometriosis
By Murat Osman
A recent manuscript published by Collins et al. from the Department of Radiology at Penn State Hershey Medical Center aims to review the transvaginal ultrasound (TVUS) evaluation of endometriosis and offer a protocol that is dedicated to the thorough evaluation…
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Increased obstetrical complications after ART therapy in endometriosis patients.
By Selma Oransay
To examine the impact of endometriosis and adenomyosis on ART therapy, Harada et al. from the Department of Obstetrics and Gynecology of Tottori University, Japan, planned a prospective cohort study and published their results recently in PLoS One. The study…
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Endometriosis of the Appendix
By Timur Seckin
Endometriosis of the gastrointestinal tract is infrequent, and it rarely involves the appendix. A group of researchers from the United States of America reported a case of a 50-year-old postmenopausal woman with endometriosis in the vermiform appendix presenting as acute…
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Serum anti-Müllerian hormone levels for predicting spontaneous pregnancy after endometriosis surgery
By Hale Goksever Celik
Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Although there are several medical and surgical therapeutic options, the most effective treatment modality has not yet been elucidated. The main…
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Study Sheds Light on Physiological Processes Associated with Endometriosis
By Özge Özkaya
Sensory nerves play an important role in the development of endometriosis as well as fibrosis, confirms a study by Chinese researchers. A better understanding of physiological processes associated with the development of endometriosis can help researchers devise new ways to…
Key Points Lay Summary
Endometriosis as an epigenetically regulated disease
By Dr. Youngran Park
Endometriosis is defined as the abnormal growth of endometrial tissue outside of the uterus. It affects about 10% of reproductive age women resulting in severe pain and infertility. Among various theories of endometriosis pathogenesis, not a single one has successfully…
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Consquences of endometriosis in menopausal period.
By Selma Oransay
Marie-Scemama et al. from Foch Hospital, Suresnes, France, referred to endometriosis and menopause which is an actual cruising topic and recently published it in the journal named "Hormone Molecular Biology and Clinical Investigation". Endometriosis a well-known estrogen-dependent disease has three…
Key Points Lay Summary
Is there any difference between endometriosis patients with or without obliterated cul-de-sac during laparoscopic hysterectomy?
By Hale Goksever Celik
Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. It is diagnosed in 10% to 15% of reproductive-aged women. Women with endometriosis demand therapy for the most common symptoms, which are…
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A new technique for laparoscopic management of ovarian endometriosis.
By Selma Oransay
To cause a minimal hazardous effect on ovarian reserve during laparoscopic surgery of endometriomas is always a great concern for clinicians. Shaltout et al. from Cairo University, Egypt, examined the effect of "Surgicel" on preventing the recurrence of endometriomas and…
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Which surgical approach for bowel endometriosis?
By Irem Onur
A group of researchers from Spain, led by Dr. Alicia Hernández Gutiérrez, conducted a retrospective study to compare postoperative complications and recurrence of three surgical techniques: segmental bowel resection (group I), discoid excision (group II), and rectal nodule shaving (group…
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Perinatal risk factors for endometriosis
By Irem Onur
Gao M. et al., from Sweden analyzed the associations of maternal and birth characteristics with the risk of endometriosis among Swedish women of reproductive age. They have recently published their study in the "International Journal of Epidemiology". The authors conducted…
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New Protein for Endometriosis Diagnosis
By Özge Özkaya
A protein called TIMP3 (tissue inhibitor of metalloproteinase-3) could be used for the diagnosis and prognosis (likely course) of endometriosis. The early diagnosis of endometriosis is of paramount importance because it can help to diagnosis and thus initiate the right…
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Does ovarian endometriosis affect oocyte quality?
By Dr. Youngran Park
Endometriosis is a very common gynecological disorder affecting women in their reproductive years. It is reported that patients with endometriosis have reduced implantation and pregnancy rates compared to healthy women. According to the various previous studies, the quality of the…
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How does pregnancy affect endometriosis?
By Hale Goksever Celik
Endometriosis is the localization of endometrial stromal and glandular cells outside the uterine cavity. Pregnancy is offered as a treatment option for patients with endometriosis because it causes atrophy of endometrial cells similar to progesterone treatment. Progesterone predominance during pregnancy,…
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Using social media to raise awareness for endometriosis
By Demet Candaş Green
Raise your hand if you have used internet or social media to search for information today. We all do, every single day. Whether it is a recipe, biography of a favorite singer, reviews of a new restaurant, or today’s weather,…
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Endometriosis and the quality of life
By Selma Oransay
Recent developments of technics and improvement of skill in the laparoscopic field increased the courage of clinicians to attempt early and multiple diagnostic operations on endometriotic patients. Vanuccini et al. from NEUROFARBA, University of Florence, Florence, Italy recently published their…
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Is there an association between endometriosis and sexual activity during menstruation ?
By Nasuhi Engin Aydin
This recent case-control study with 185 women having endometriosis and 370 women as a control group was conducted in Tebriz University, Iran by Dr. Mollazadeh and associates. Contemporarily, retrograde menstruation is a valid theory for disseminating endometrial tissue to the…
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Analysis of childless women with endometriosis
By Irem Onur
Facchin F. et al., from Italy studied if the beliefs of childless women regarding motherhood, female identity, and infertility affected their psychological health. They have recently published their study in the Journal of Health Psychology. The data of this study were…
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How Long Does it Take to Be Diagnosed with Endometriosis?
By Özge Özkaya
It takes a median of eight years to reach a diagnosis of endometriosis from when the symptoms of the condition first appear confirmed a new British study. Interestingly, it seems that the earlier the symptoms appear, the later the disease…
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Patients preferences for the treatment of endometriosis-associated pain
By Hale Goksever Celik
Endometriosis is defined as the location of endometrial stroma and glands outside the uterine cavity. The most common presenting complaints are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility, most of which relate to the menstrual period. Those women affected…
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MicroRNA Inhibitor as an Endometriosis treatment
By Dr. Youngran Park
Endometriosis is a well-known estrogen-dependent gynecological disorder. This disease affects approximately 20% to 50% of infertile women and 10% of reproductive-aged women resulting in infertility and pelvic pains. In order to find endometriosis-specific treatment, various studies have been tried to…
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Adolescent dysmenorrhea and future endometriosis
By Selma Oransay
Dysmenorrhoea is typically classified as primary, or secondary due to underlying pathologies like fibroids, endometriosis, adenomyosis or uterine anomalies. Generally, long-term dysmenorrhea is present in endometriotic patient's anamnesis, but until recently, the research to clarify this connection remained retrospective. Knox et…
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Impact of Endometriosis on Embryo Development
By Dr. Youngran Park
Endometriosis is a hormone-dependent disorder which affects approximately 10% of women in reproductive age. There are many endometriosis-related problems, but infertility is one of the well-known issues which should be handled and understood. Despite numerous trials, the mechanisms and pathology…
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Clinical trial for the use of oral lactobacillus on endometriosis pain severity
By Yu Yu
The standard treatment of endometriosis consists of surgery and hormonal based treatment. There is evidence for the efficacy of these types of treatment, although their side effects remain a critical consideration for women. Based on molecular studies, changes in the…
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How to predict complications for endometriosis surgery?
By Timur Seckin
In a new study co-led by scientists at Sorbonne University, a nomogram is built to better inform patients about the risk of deep endometriosis surgery without bowel involvement. The findings have been published in the European Journal of Obstetrics &…
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Melatonin receptors and their role in endometrial cell proliferation
By Hale Goksever Celik
Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Despite extensive research, the exact pathophysiological mechanism and the optimal management of endometriosis still remains unclear. Management of endometriosis should aim to relieve pain,…
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Atherosclerotic cardiovascular disease and endometriosis
By Nasuhi Engin Aydin
Dr. Omur Taskin and associates from British Columbia, Canada, have recently published a review regarding the potential link between atherosclerotic cardiovascular disease (ASCVD) and endometriosis in The Journal of Minimally Invasive Gynecology. Atherosclerotic cardiovascular disease is the leading cause of…
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Not a malignancy, it is "polypoid endometriosis"
By Irem Onur
Ghafoor S. et al., from Memorial Sloan Kettering Cancer Center, NY, USA, has recently reported a case of a 60-year-old postmenopausal woman with an incidental pelvic mass mimicking a pelvic malignancy on ultrasound. Their paper has been published in the…
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DNA repair defects and Endometriosis
By Dr. Youngran Park
Endometriosis is a hormone-dependent disorder and highly associated with inflammation. It is well suggested that endometriosis increases the risks of developing cancers such as ovarian, breast, endocrine, and colorectal cancers. Compared to cancer, there are many similarities in endometriosis. Well-known characteristics…
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What happens to women with endometriosis after menopause?
By Selma Oransay
Endometriosis affects women in their reproductive period of life, with expected regression of lesions in the postmenopausal period. Literature about postmenopausal endometriosis assessing the prevalence, pathogenesis, and treatment is limited. As 2-5 % of postmenopausal women are affected by this uncommon condition, developing stress…
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Disparities in Access to Healthcare in Women with Endometriosis
By Özge Özkaya
There are significant differences in the use of medical services and prescriptions between women with endometriosis who have private healthcare and those who don’t. This is according to a study published in the American Journal of Obstetrics and Gynaecology. This…
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A miniaturized version of endometrium: organoids for endometriosis research
By Yu Yu
Organoids are a miniaturized version of a tissue that is produced in culture through three dimensions techniques in order to better mimic the tissues of origin. These cultures are supposed to better replicate the complexity of a biological organ/disease. Endometrial…
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The accuracy of "lower endoscopic ultrasound" for the preoperative diagnosis of rectosigmoid endometriosis
By Hale Goksever Celik
Endometriosis affects reproductive-aged women most frequently with a prevalence of 5% to 15%. If the endometriotic lesions involve the bowel especially sigmoid colon and rectum, this subtype of endometriosis is named as "bowel" or "rectosigmoid" endometriosis. Rectosigmoid endometriosis is encountered in…
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Plausible biomarkers for noninvasive endometriosis diagnosis
By Dr. Youngran Park
Endometriosis is an estrogen-dependent benign gynecological disease characterizing ectopic deposition of endometrial tissue outside of the uterine cavity. It affects about 10% of reproductive-aged women and causes enormous negative impacts on the quality of lives. However, we do not have…
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Nanotechnology as a tool for targeted therapy of endometriosis
By Murat Osman
Endometriosis is a process whereby endometrial cells persistently grow and invade extra-uterine tissue through a primarily estrogen-dependent manner. These ectopic endometrial cells proliferate in sometimes an uncontrolled manner, similar to cancer or inflammatory tissues. To proliferate, cells need cholesterol to…
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How to Classify Endometriosis for a better and effective evaluation
By Selma Oransay
Endometriosis affects 10% of women in their reproductive period and causes infertility around 40% of women who have the disease. Peritoneal fluid may be one of the factors to facilitate the spread of endometriosis to ovaries, peritoneum and other deep…
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Mortality of 49956 midlife women with surgically verified endometriosis
By Irem Onur
Saavalainen L. et al., from Finland recently published a retrospective large cohort study in the journal Human Reproduction, where they retrospectively examined the data of surgically verified endometriosis patients to find out if all-cause and the cause-specific mortality rate is…
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Which Diagnosis Technique is Better?
By Özge Özkaya
Transvaginal ultrasound provides a more accurate localization of vaginal and recto-vaginal endometriosis compared to magnetic resonance imaging (MRI) according to a study published in the International Journal of Gynecology & Obstetrics. However, MRI has better accuracy in detecting bladder endometriosis…
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Pregnancy with endometriosis
By Demet Candaş Green
Current literature suggests that complications of endometriosis during pregnancy are rare; however, a non-negligible increase in the likelihood of placenta accreta (placenta grows too deeply into the uterine wall), preterm birth, and cesarean delivery has been reported. With the increase…
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By Deniz KocasPrescription Opioid Use in Women With Endometriosis
By Deniz Kocas
In this study, researchers examined opioid use, opioid prescribing patterns, and timing of the first opioid prescription in endometriosis patients compared with matched women in the control group without endometriosis. A retrospective analysis of Optum Clinformatics Data Mart was conducted.…
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Infertility in women with endometriosis
By Hale Goksever Celik
Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. The most common presenting complaints are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Despite extensive research, the etiopathogenic mechanism underlying the two has not been fully elucidated. Although human…
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The Effect of Imbalanced Progesterone Receptors-A/B on Gelatinase Expressions in Endometriosis
By Dr. Youngran Park
Endometriosis is a benign disease which affects approximately 10% of reproductive-aged women and is one of the most common reasons for infertility. Though the underlying mechanisms of disease progression have not been clearly understood, it develops as a consequence of…
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Fusion US/MR imaging in the evaluation of deep infiltrating endometriosis
By Timur Seckin
Scioscia M. et al., from Italy presented a case of a large deep infiltrating nodule of the uterosacral ligament and discussed the importance of a relatively new technique, fusion US/MR imaging in their article. The article containing a video of…
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Endometriosis that involves the nerves: how Radiologists can help
By Murat Osman
Endometriosis is a disease with variable clinical symptoms. While rare, nerve involvement by endometriosis may cause neurologic symptoms such as pelvic pain, muscle weakness, bowel and bladder incontinence, and paraplegia depending on the specific nerve involved. Thus, abdominal radiologists should…
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A position statement of diagnosing and treating endometriosis for gynecologists.
By Selma Oransay
Endometriosis Treatment Italian Group recently declared 10 "valuable" conducts to evaluate endometriotic patients and published them in Hum. Reprod. Open. This society consists of 16 university departments and training center with expert clinicians on endometriosis from Italy. After arising the idea of…
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Botox as a promising treatment for chronic pelvic pain in endometriosis
By Irem Onur
Botulinum toxin (Botox) for treating chronic pelvic pain specifically addressing women with endometriosis has been studied for the first time by Tandon et al., from Bethesda, Maryland, USA. Their paper has recently been published in the journal Regional Anesthesia &…
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MRI or TVS for accurate diagnosis of rectosigmoid endometriosis?
By Demet Candaş Green
Rectosigmoid endometriosis (RE) is seen in about 90% of patients with bowel endometriosis. Rectosigmoid is the region between the rectum and the sigmoid colon, which is a region easily accessed and assessed by two most common noninvasive imaging modalities –…
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Health care resource utilization and cost in women with endometriosis
By Hale Goksever Celik
Endometriosis is a chronic inflammatory disease affecting 6-10% of reproductive-aged women. The clinical picture of the disease range from asymptomatic findings to dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Endometriosis has also complex etiopathogenetic background. This broad clinical spectrum, the…
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Chronic Fatigue Syndrome and Endometriosis: Comorbid Conditions
By Irem Onur
In the study of Dr. Boneva et al., from Atlanta, GA, the United States which has recently been published in the journal Frontiers in Pediatrics evaluated the impact of endometriosis on the health of women with chronic fatigue syndrome (CFS). The authors compared…
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Patients with Pelvic Pain Most Likely to Benefit from Endometriosis Surgery
By Özge Özkaya
Women who experience higher levels of pain are more likely to show improvement in their quality of life (QoL) following endometriosis surgery, according to a study published in The Journal of Minimally Invasive Gynecology. Chronic pelvic pain seems to be…
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Surgical treatment of deeply infiltrating endometriosis in tertiary treatment centers
By Demet Candaş Green
In the present study, data from patients who were surgically treated for deep infiltrating endometriosis (DIE) in a tertiary referral unit, the Avicenna Centre for Endometriosis and Minimally Invasive Gynecology (ACEMIG, Tehran, Iran), were examined for rates of intraoperative and…
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The predictors for the coexistence of uterine leiomyomas and endometriosis
By Hale Goksever Celik
Uterine leiomyomas are the most common gynecological benign tumors affecting 20-25% of reproductive-aged women. Abnormal bleeding, pelvic pain, pelvic pressure, and infertility are major symptoms of these tumors. Endometriosis is another gynecological disease encountered in 10-15% of reproductive-aged women. The…
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Control on endometriosis progression by a "tyrosine kinase inhibitor"
By Irem Onur
B cells, which are important players of the immune system, are increased in the blood and peritoneal cavity of endometriosis patients. Activation of B cells and the presence of anti-endometrial autoantibodies have been also been described in women with endometriosis,…
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Transvaginal Ultrasound and the Imaging of Endometriosis
By Murat Osman
Ultrasonography (US) is an imaging tool that uses sound waves to produce a two-dimensional picture inside of the body. The ultrasonography has become especially useful in the assessment of gynecologic pathologies such as endometriosis. Depending on the severity of endometriosis,…
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Importance of monocytic myeloid derived supressor cells in endometriosis
By Nasuhi Engin Aydin
Myeloid-derived suppressor cells MDSCs are immature myeloid cells that play a major role in immunosuppression in various disease processes. Ya Sun and associates have investigated these cells in endometriosis utilizing various laboratory methods. published their results in the "American Journal of…
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"Endometriosis", "Fibromyalgia" and "Autoimmune diseases"
By Irem Onur
Greenbaum et al. from Israel, investigated the prevalence of and the association between endometriosis, fibromyalgia and autoimmune diseases in a large population database and described healthcare resource utilization in affected women. Their study has been published in the "American Journal…
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Seven Hormonal Biomarkers for Diagnosing Endometriosis
By Dr. Youngran Park
Endometriosis is an inflammatory condition characterized by implantation and invasive growth of endometrial tissue outside the uterine cavity. Although it is benign, endometriosis has cancer-like features, a mutation profile similar to that of ovarian cancer, and increased ovarian cancer risk.…
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Baby Years and the Risk of Endometriosis
By Özge Özkaya
Early-life factors such as whether a baby was breastfed, have had vaginal bleeding at birth, or whether or not their father was a smoker may be associated with her risk of developing endometriosis in later life. This is according to…
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Analogous pathways of peritoneal tumor wound healing and endometriosis.
By Selma Oransay
Endometriosis, diagnosed around 10-15% of women population in their reproductive period, is a chronically progressive inflammatory disease to cause peritoneal lesions while spreading into the abdominal cavity. The pathophysiology of the adhesions between the peritoneum and pelvic organs can be…
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Endocrine-disrupting chemicals – yet another environmental factor associated with endometriosis?
By Demet Candaş Green
This study by Wen et al., published in Gynecological Endocrinology, analyzed evidence connecting endocrine-disrupting chemicals (EDCs) to the incidence of endometriosis in a collection of 30 previously published studies. Results show that exposure to many EDC's are linked to the…
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Urocortin: A biomarker deserving investigation for endometriosis patients
By Irem Onur
Urocortin is a neuropeptide in the corticotropin-releasing hormone family and is expressed by eutopic and ectopic human endometria. Since it has paracrine and immunomodulatory effects, urocortin is thought to contribute to the pathogenesis of endometriosis. Its expression has been thoroughly…
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The coelomic metaplasia hypothesis of endometriosis in MRKH cases
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity and its incidence is approximately 10% in the general female population. Although the pathophysiological mechanism is not clearly understood, the implantation theory by Sampson…
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ENDORECT scoring system to identify patients at risk for rectosigmoid endometriosis
By Murat Osman
Patients who suffer from endometriosis may benefit from a preoperative score that predicts rectosigmoid involvement. A recent paper published by Huchon et al. at Poissy Saint-Germain en Laye, France, recruited 119 women who underwent laparoscopy for endometriosis between 2011 and…
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Endometriosis pathophysiology: research in genes updated
By Nasuhi Engin Aydin
Endometriosis has a broad spectrum of environmental influences and genetic factors. I In this recently published review article in Experimental and Therapeutic Medicine, Vassilopoulou and associates present information about gene‑gene and gene‑environment interactions involved in endometriosis and discuss the effectiveness…
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Novel inhibitors of estrogen biosynthesis
By Dr. Youngran Park
Endometriosis is a chronic benign disease which is estrogen-dependent. Estradiol creates a positive feedback loop with the synthesis of pro-inflammatory mediators, which sustains further disease establishment and causes the pain symptoms. However, hormone therapies do not cure definitively endometriosis, because…
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Searching new biomarkers for endometriosis
By Selma Oransay
This recent article published in Advances in Clinical Chemistry, is an overall summary of characteristics, physiopathological theories, diagnostic approaches and variety of biomarkers to diagnose endometriosis and penned by Coutinho et al. from Universidade Federal de Juiz de Fora, Belo Horizonte,…
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The association of significant hemoperitoneum (blood in the abdominal cavity) and deep pelvic endometriosis
By Irem Onur
Although there are several theories to explain the etiology of deep endometriosis, the cause is unknown and there are currently no effective strategies to prevent its development. Bean E. et al., from University College London Hospital, UK, observed that some…
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The Wnt/b-catenin signaling in endometriosis
By Dr. Youngran Park
Endometriosis is a very common gynecological disorder, which affects approximately 10% of reproductive-aged women, and is one of the most common reasons for infertility. The normal endometrium undergoes cyclical remodeling under control of sex hormones secreted by ovaries- estrogen and…
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Non‑invasive biomarkers for endometriosis diagnosis
By Hale Goksever Celik
Endometriosis is a disease of women in reproductive age and its incidence varies between 5-10%. Since the diagnosis is based on the histological confirmation, there is an average of 7 to 11 years of delays in the diagnosis. Promising non-invasive…
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The reason for lower BMI and less body fat in women with endometriosis.
By Selma Oransay
Zolbin et al. from the Department of Obstetrics and Gynecology of Yale School of Medicine, New Haven, USA, recently published the results of their prospective controlled research on adipocyte alterations in endometriosis, in the journal "Reproductive Biology and Endocrinology". Endometriosis can…
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Fibrogenesis in endometriosis: The role of neuropeptides
By Dr. Youngran Park
Endometriosis is a debilitating gynaecologic disease affecting 6–10% of women of reproductive age. Endometriotic lesions are known to be hyperinnervated due to neurogenesis resulting from neutrophins secreted by endometriotic lesions and possibly platelets. These neutrophins seem to preferentially favor the…
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By Serdar BalciPathophysiology of peritoneal endometriosis pain.
By Serdar Balci
This article is an invited editorial by Ferrero S et.al. from IRCCS Ospedale Policlinico San Martino, Genoa, Italy, published in the Annals of Translational Medicine. The authors describe the pathophysiology and underlying mechanisms of pain in peritoneal endometriosis with reference to the…
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The genetic predisposition to endometriosis
By Hale Goksever Celik
Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. Although endometrium is a non-malignant disease, its symptoms can range from mild to severe due to the inflammation that ectopic endometrial tissue forms around itself. The exact etiopathogenetic mechanism…
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A new hope for a "targeted" drug for endometriosis
By Selma Oransay
Lin et al. from National Cheng Kung University, Taiwan, recently published in"Theranostics" the article entitled "Targeting Anthrax Toxin Receptor 2 Ameliorates Endometriosis Progression”, report that ANTRX2 may be a novel therapeutic target for endometriosis. Thinking that the adhesion should be the first and the…
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Anti-angiogenic treatment for endometriosis
By Dr. Youngran Park
Endometriosis is a benign, estrogen-dependent gynecological disorder. The wide variety of surgical and medical treatment has been applied for treating endometriosis, but a definitive therapy has not been achieved so far. Thus, new therapeutic strategies need to be developed. Among…
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Proposed algorithm for a clinical diagnosis of endometriosis.
By Selma Oransay
This recently published article in the American Journal of Obstetrics and Gynecology is about the challenge of diagnosing endometriosis, its impact on women's daily life and authored by Agarwal et al. from The University of California, San Diego, CA, USA. Authors called attention…
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Adenomyosis (endometriosis interna): an enigmatic disease that has to be discovered yet
By Nasuhi Engin Aydin
Scientists, Drs. Vannuccini and Petraglia from Italy have published an open access comprehensive review of Adenomyosis in "F1000Research" in March 2019 issue. Adenomyosis is a uterine disorder in which endometrial glands and stroma are pathologically demonstrated within the myometrium, i.e.…
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Endometrial single cells to contribute preexisting endometriosis.
By Dr. Youngran Park
Endometriosis is an estrogen-dependent inflammatory disease. This disease affects approximately 10% of reproductive-aged women and 20% to 50% of infertile women. Multiple hypotheses have been proposed for the origin of endometriosis. Retrograde menstruation is believed to take part by the…
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Reducing the Risk of Recurrence After Endometriosis Surgery
By Özge Özkaya
The use of compounds called NF-κB inhibitors and β-blockers before and after endometriosis surgery may reduce the risk of the disease recurring, according to a study conducted in a mouse model. According to the study published in the journal Reproductive…
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Antibiotic therapy for endometriosis
By Yu Yu
Current treatments for endometriosis are surgery and hormone therapy; however, these approaches may have significant side effects and do not prevent a recurrence. Therefore, alternative treatment modalities for endometriosis is needed. Recently, the idea that endometriosis may be influenced by…
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The postoperative functional outcomes of deep infiltrating endometriosis
By Hale Goksever Celik
Rectosigmoid endometriosis is defined as the infiltration of the bowel wall with the endometrial-like glands and stroma, reaching at least the muscular layer. The most commonly involved sites are the rectum and sigmoid colon. For the management of deep infiltrating…
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A new trial to reduce the failure of IVF/ICS protocols in severe endometriosis
By Selma Oransay
Kong et al., from the first affiliated hospital of Zhengzhou University, China, recently published this single-blinded, a multicentered and randomized controlled study in the Journal of Reproductive Health, with the aim to find a safer and more effective ovulation induction regimen for patients with…
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Endometriosis and nuclear receptors
By Dr. Youngran Park
It is well recognized that endometriosis is a steroid-dependent disorder. In endometrial stromal cells, progesterone regulates retinoic acid production and action. Retinoids also act via a number of nuclear receptors (NRs) and are involved in normal endometrial function and endometriosis. Estrogen…
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Bladder Endometriosis
By Demet Candaş Green
Bladder endometriosis is rare – about 1-2% of women with endometriosis may have endometrial lesions in their urinary tract. Diagnosis of bladder endometriosis is difficult because of its nonspecific symptoms such as frequent urination, pelvic pain, and burning sensation when…
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The coexistence deep infiltrating endometriosis and fibromyalgia
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The main symptoms of endometriosis which are dysmenorrhea, dyspareunia, and chronic pelvic pain impair the quality of life of these women. This disease may…
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MRI-based "ENZIAN" scoring system and intra-operative endometriosis findings
By Murat Osman
Endometriosis is a chronic inflammatory disease whereby endometrial-like glands grow and invade the extra-uterine structures. Endometriosis may affect various parts of the body, including the peritoneum, ovaries, or retroperitoneum. Recently, non-invasive methods for detecting these lesions have included trans-vaginal ultrasound…
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Epithelial Mutations in Endometriosis
By Dr. Youngran Park
A substantial body of epidemiologic evidence suggests a link between endometriosis and epithelial ovarian cancer, but a plausible underlying mechanism has remained elusive. Here, Dr. Bulun group from Northwestern University provide a focused review of the literature and discuss the…
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A highly sensitive Immunohistochemical Marker for Stromal Cells in endometriosis
By Nasuhi Engin Aydin
Endometriosis is diagnosed histopathologically by the presence of endometrium-like tissues outside the uterus. Positive CD10 immunohistochemistry, highlighting stromal cells of the endometrium, is a useful adjunct for pathologists in the tissue diagnosis. However, CD10 expression is not specific to endometrial stromal…
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A guide on the Assessment of Pelvic Endometriosis Imaging
By Murat Osman
Endometriosis is a disease whereby ectopic endometrial-like tissue invades and survives outside of the endometrial cavity. While biopsy-proven confirmation of endometriosis during laparoscopy has been considered the gold standard for diagnosis, non-invasive imaging modalities are increasingly being utilized for preoperative…
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Can early-life exposures affect endometriosis development later in life?
By Demet Candaş Green
Endometriosis is a complex disease with possible multifactor contributors. So far, inflammatory, immunogenic, genetic, and environmental factors have all been associated with endometriosis. In addition, it is possible that different types of endometriosis lesions – peritoneal, ovarian, and deep infiltrating…
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