By Selma OransayPeritoneal endometriosis and Peritoneal Immunity
By Selma Oransay
The peritoneum is an important immune barrier where, under normal conditions, it is balanced. External stimuli cause pro-inflammatory responses. To bring balance to this undesired situation, anti-inflammatory factors come into play. However, in patients with endometriosis, cytotoxicity of T lymphocytes,…
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By Özge ÖzkayaEndometriosis Associated With Metabolic Syndrome
By Özge Özkaya
There seems to be a link between endometriosis and metabolic conditions, according to a new study published in the scientific journal Gynecological Endocrinology. This finding suggests that close attention should be paid to metabolic conditions in women with endometriosis and…
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By Hale Goksever CelikEndometriosis and Physical Activity
By Hale Goksever Celik
Endometriosis causes abstinence from their daily life, especially during painful periods. Decreased physical function might result in reduced physical activity. Sachs et al., from Switzerland, published a study titled “Physical Activity in Women with Endometriosis: Less or More Compared with…
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By Eylül GÜNAlterations of mitochondrial dynamics in endometriosis
By Eylül GÜN
Mitochondria are known as the batteries of the cell with the ATP that they produce through oxidative phosphorylation. Mitochondrial dynamics are important mechanisms for mitochondria to maintain their integrity by continuously undergoing changes. Mitochondrial fusion is the joining of two…
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Exploring endometriosis symptoms and their effects on women's lives
By Eylül GÜN
Endometriosis symptoms, their severity, and the way they affect patients' lives may vary. With the aim of investigating different personal experiences and perceptions of endometriosis symptoms and the way they impact women's daily lives, Hunsche and colleagues from Switzerland and…
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Healthcare Seeking Behaviour May Be Sign of Endometriosis
By Özge Özkaya
Women with endometriosis had a higher utilization of primary and secondary healthcare in the 10 years before receiving a diagnosis, found a new study published in the scientific journal Human Reproduction. “With this knowledge, healthcare professionals could be better at relating…
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Elevated iron levels in "endometriosis pathogenesis"
By Selma Oransay
The presence of abnormal levels of iron and ferritin in endometriotic lesions is likely due to repeated bleeding episodes. When red blood cells break down, the iron content is released, which can cause inflammation leading to damage to surrounding tissues.…
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By Nasuhi Engin AydinA pioneering study on clinicopathologic features of biopsies of endometriotic lesions
By Nasuhi Engin Aydin
Deep infiltrating endometriosis, where endometriotic lesions have an invasion depth of ≥5mm to the underlying tissues, is well known due to the troublesome features, peritoneal endometriosis is very common and widely distributed by superficial involvement in the pelvic visceral and…
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By Bahar YukselThe Molecular Mechanisms of how herbal medicine Actaea racemosa modulates Endometriosis Progression
By Bahar Yuksel
Increased proliferation, dysregulated apoptosis, and a pro-inflammatory and oxidative environment are the hallmarks of endometriosis. In the article published in the Journal of Molecular Sciences, penned by Livia Interdonato et al, the molecular mechanisms of the extract from a plant…
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Treatment of superficial dyspareunia using topical estrogens in postmenopausal women with a history of endometriosis
By Hale Goksever Celik
Genitourinary syndrome of menopause is defined as a collection of symptoms and signs caused by hypoestrogenic changes to the labia majora/minora, clitoris, vestibule/introitus, vagina, urethra, and bladder that occur in menopausal patients. Sexual dysfunction and superficial dyspareunia can be experienced…
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Assessing endometrial receptivity using menstrual blood samples in patients undergoing in-vitro fertilization
By Eylül GÜN
Endometrial receptivity is the endometrium's capacity to allow the embryo the chance to adhere, infiltrate, and develop while ensuring an ideal microenvironment. When impaired, it is one of the two major factors contributing to infertility along with embryo quality by…
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A review for genetics of endometriosis.
By Selma Oransay
There is an increased risk of developing endometriosis among first-degree relatives, which can raise suspicions of the role of genetic factors in endometriosis. Genome-wide association studies and next-generation sequencing have identified numerous genetic loci and variants relating to the disease.…
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A comparative analysis of male and female perspectives on sexuality in couples dealing with endometriosis
By Eylül GÜN
Sexual relationships of patients with endometriosis have been an area of research lately, however, studies have focused mostly on female perceptions and opinions leaving out the males. Helfenstein et al. from Switzerland, Germany, and Austria conducted a multicenter cohort study…
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Study May Explain How Tubal Endometriosis Causes Infertility
By Özge Özkaya
Tubal endometriosis damages the epithelial ultrastructure of the fallopian tubes or the tubes connecting the ovaries to the uterus along which an egg travels each month ready to be fertilized by a sperm cell. This could help explain why tubal…
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Is continuous hormonal treatment safe and healthy method for endometriotic patients?
By Selma Oransay
One of the studies related to the search for new markers in pathophysiologic causes of endometriosis is circulating microparticles and their subset "tissue factor". In response to damage, activation, or apoptosis, these microparticles are found in human plasma, urine, saliva,…
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Toxic metal cadmium and Endometriosis
By Nasuhi Engin Aydin
Data analyst Mandy Hall and and colleagues from the Department of Epidemiology and Biostatistics, Michigan State University, USA, have published their results on cadmium levels and endometriosis in a recent issue of “Human Reproduction”. In 2020 the World Health Organization…
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Novel surgical solutions for catamenial pneumothorax
By Eylül GÜN
Catamenial pneumothorax is a spontaneous pneumothorax that occurs during or right after menstruation and is thought to be caused by thoracic endometriosis that includes the diaphragm, lung, and parietal pleura. The solution is surgical removal of endometrial lesions, however, a…
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A new classification called ENDOGRADE to rate surgical complexity in deep endometriosis.
By Selma Oransay
Correlation with patient outcomes could not be identified in most endometriosis classification systems including the commonly used revised ASRM. Therefore, in addition to grading the depth and invasion pattern of the lesions, there is a need for a classification system to…
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Preoperative flexible sigmoidoscopy in patients with deep infiltrating endometriosis
By Hale Goksever Celik
Deep infiltrating endometriosis is defined as endometriotic lesions extending 5 mm or more below the peritoneal surface. Women with deep endometriosis have rectovaginal lesions affecting the tissue adjacent to, or directly involving the rectum and/or rectosigmoid colon with a 90%…
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Women With Endometriosis More Likely to Also Have Non-Specific Symptoms
By Özge Özkaya
Women with endometriosis are more likely to report menstrual symptoms, according to a new study published in the American Journal of Obstetrics and Gynecology. However, they are also at an increased risk of mental health disorders, other pain symptoms, bowel,…
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The compliance for post-surgical follow-ups after endometriosis surgery
By Selma Oransay
. The patient's adherence to follow-ups after surgery is essential as it is the only way to evaluate the surgery's benefits in improving pain symptoms and recurrences, measuring the quality of life, and fertility outcomes. . Dr. Szabo and his…
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Does ZEB1 Gene Expression Govern Endometriosis Infiltration Pattern?
By Özge Özkaya
The expression of a gene called ZEB1 is different between different types of endometriosis, found a new study published in the European Journal of Obstetrics & Gynecology and Reproductive Biology. This could affect whether or not lesions become infiltrative. More importantly,…
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Review of neutrophil based scientific research in endometriosis
By Nasuhi Engin Aydin
Xinlei Wang and associates from Jilin University, Changchun, China, have published a comprehensive review on the pathogenetic role of neutrophils in endometriosis in a recent issue of the periodical “Mediators of inflammation”. As a common inflammatory condition where endometrial tissue…
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Unveiling the Immunological Puzzle: Modulation of Biomarkers in Endometriosis by Progestin Therapy
By Bahar Yuksel
The study by Daniela Roxana Matasariu et al., aimed to investigate the effects of progestin treatment on the expression of biomarkers in endometriosis, specifically focusing on osteopontin and CD44; and their potential role in the pathogenesis of endometriosis. The researchers…
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Moderate-to-severe Endometriosis and "The Cumulative live birth rate" in IVF Cycles
By Hale Goksever Celik
Infertility is one of the major symptoms in women with endometriosis. The incidence of endometriosis is approximately 10% in reproductive-aged women and up to 40-50% in infertile women. There are multifactorial mechanisms resulting in endometriosis-associated infertility such as anatomic distortion, impaired…
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"Transumblical single-port laparoscopy" for deep infiltrating endometriosis.
By Selma Oransay
Deep infiltrating endometriosis patients have multi-system involvements, severe pelvic adhesions, and pelvic pain. Dyspareunia, dysmenorrhea, infertility, gastrointestinal symptoms, and lower urinary tract symptoms seriously affect their quality of life. Although hormonal therapy may be the first choice for treating endometriosis,…
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The public plea of international group of "endometriosis experts"
By Nasuhi Engin Aydin
A group of international “endometriosis experts” led by Professor Philippe R. Koninckx from Belgium, have published their unique scientific paper “The 10 “Cardinal Sins” in the Clinical Diagnosis and Treatment of Endometriosis: A Bayesian Approach” in a recent issue of…
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Role of peritoneal dendritic cells in endometriosis development
By Eylül GÜN
Dendritic cells (DCs), essential antigen-presenting cells bridging innate and adaptive immunity, play a pivotal role in immune response modulation. They capture process, and present antigens, facilitating T-cell activation. DCs also promote self-tolerance by releasing tolerogenic cytokines, contributing to autoimmune disease…
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Dienogest versus combined oral contraceptives treatment in postoperative endometriosis care
By Selma Oransay
Dienogest is a synthetic progestin derivative, like oral contraceptives, used to prevent endometriosis recurrence after surgery. Randomized clinical trials verified a significantly higher reduction in endometriotic lesions, clinical symptoms, and improved quality of life obtained when dienogest was given to…
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Endometriosis of the skeletal muscular system
By Eylül GÜN
Endometriosis of the skeletal muscular system (ESMS) is characterized by the presence of endometrial cells in skeletal muscles, bones, or joints. Despite its rare occurrence, ESMS has been reported in various muscle and joint locations, leading to atypical symptoms and…
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New SMS Program Available for Endometriosis Patients
By Özge Özkaya
Researchers from Australia developed a supportive short message service (SMS) program for endometriosis patients. The program aims to support women living with endometriosis to manage their condition. The program called 'EndoSMS" was designed based on the needs and preferences of…
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A Starch-Based Gel Barrier Reduces Pain and Improves Fertility After Endometriosis Surgery
By Özge Özkaya
The development of pain was reduced in women with endometriosis who underwent surgery for deep infiltrating endometriosis (DIE) resection and the "gel barrier 4DryField® PH" was used during the operation, according to results from a randomized controlled trial. Moreover, fertility was improved. "4DryField® PH"…
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Are women with endometriosis more prone to pregnancy loss?
By Hale Goksever Celik
Endometriosis is a gynecological disease of reproductive-aged women who may suffer from reproductive outcomes such as infertility, miscarriage, and recurrent pregnancy loss. Pregnancy loss is the spontaneous loss of a pregnancy until 22 weeks of gestation including spontaneous abortion, missed…
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Telemedicine for endometriosis
By Eylül GÜN
The COVID-19 pandemic led to the widespread adoption of telemedicine, allowing healthcare professionals to provide care remotely using technology. Telemedicine has proven successful in various medical fields. In obstetrics and gynecology, implementing telemedicine became crucial, especially for conditions like endometriosis.…
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Harnessing the Power of the Immune System: The Potential of Immunotherapy for Treating Endometriosis
By Bahar Yuksel
The review article by Wenshu Li et al. discusses the potential of immunotherapy as a novel treatment for endometriosis and the potential to overcome possible side effects and recurrence rates related to conventional therapies. The article explains how immunotherapy, which…
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Postoperative outcomes of laparoscopic rectosigmoid resection for bowel endometriosis.
By Selma Oransay
Rectosigmoid endometriosis comprises 80-85% of all bowel endometriosis cases and can be localized in the rectovaginal septum, uterosacral ligaments, retro-cervical region, and parametrium. Symptoms of rectosigmoid endometriosis include abdominal bloating, constipation-diarrhea, lower-back pain, dyschezia, and sometimes cyclic rectal bleeding. Minimally…
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Ultrasound and #Enzian Classification for Endometriosis
By Özge Özkaya
The #Enzian classification can ensure endometriosis is systematically described and classified, which can “greatly facilitates communication between physicians and patients, sonographers and surgeons,” according to an editorial article by Drs. Jörg Keckstein and Markus Hoopmann published in the European Journal of…
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Pain Scoring System for Deep Endometriosis
By Selma Oransay
The numeric pain scale is commonly used to interpret pain score values. According to the National Comprehensive Cancer Network guidelines, pain scores of 4-7 points indicate moderate, and 8-10 points indicate severe pain. Patients with a local pain score of…
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Sexual activity during menstruation: Any impact on endometriosis development?
By Eylül GÜN
Retrograde menstruation is among the theories for the etiology of endometriosis and there is a hypothesis that sexual activity during menstruation could potentially increase retrograde menstruation, leading to the implantation of endometrial tissue in other areas and consequently increasing the…
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Ovarian cancers arising in endometriosis: still an unresolved issue
By Nasuhi Engin Aydin
Alice Bergamini and associates from San Raffaele Scientific Institute, Milan, Italy have published their results on clinicopathologic features of endometriosis-associated ovarian cancers in a recent issue of the journal “Diagnostics”. The association between endometriosis and ovarian cancer was first noticed…
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Outcomes of improving chronic pelvic pain with "immersive digital therapeutics" at home.
By Selma Oransay
Studies have shown that virtual reality can effectively treat acute pain experienced by burn victims, during labor, dental surgery, or for chronic musculoskeletal, neuropathic, and cancer pain. Considering the effectiveness of treating chronic pelvic pain at home, Merlot et al.…
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Endometriosis and Genetic Polymorphisms in Proinflammatory Cytokines
By Hale Goksever Celik
Several pathophysiological mechanisms have been proposed for the chronic inflammatory nature of endometriosis, such as retrograde menstruation, coelomic metaplasia, hormonal change, oxidative stress and inflammation, immune dysfunction, and apoptosis suppression. One of the most widely accepted theories in recent years…
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Autoimmune Disorders in Women with Endometriosis May Impair Embryo Implantation
By Bahar Yuksel
The retrospective study by Noemi Salmeri reports the effect of concomitant autoimmune disorders on the ability of the endometrium to support embryo implantation in women with endometriosis who underwent assisted reproductive technology (ART) treatments. The study involved 600 women with…
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A new potential biomarker proposal from leukorrhea of endometriosis patients
By Eylül GÜN
Endometriosis is typically diagnosed through laparoscopic surgery, which can be invasive and discourages some patients from participating. Therefore, there is a need for a non-invasive diagnostic method. Exosomes, small vesicles containing biological information, can be found in almost every type…
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Outcomes of chronic pelvic pain after niche repair
By Selma Oransay
Rapidly increasing cesarian section rates in recent years increased the cesarian scar defects and the development of "isthmoceles". Isthmocele is a myometrial lesion located around the isthmic portion of the uterus that is a myometrial discontinuity or hypoechoic triangle in…
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Conditioned medium from adipose tissue derived stem cells for endometriosis treatment
By Eylül GÜN
Despite the effectiveness of both surgical and medical treatments in addressing complications related to endometriosis, there is still a high recurrence rate indicating the need for the development of novel therapeutic approaches to enhance the effectiveness of endometriosis treatment. Adipose-derived…
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Preoperative MRI Scoring System Could Ensure Women Are Fully Informed
By Özge Özkaya
The Deep Pelvic Endometriosis Index is able to predict the length of surgery and hospital stay as well as complications following surgery including voiding dysfunction, according to a new multicenter cohort study, the results of which were published in The Journal…
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Changes over time in day surgery for endometriosis in Canada
By Hale Goksever Celik
There are several medical and surgical treatment options for the management of endometriosis. Surgical approach is generally preferred in women with atypical endometrioma appearance on ultrasound, and who have persistent pain despite medical treatment. Surgery is often the first choice…
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Getting help from water to replace colonoscopy and MRI for the diagnosis of deep bowel endometriosis.
By Bahar Yuksel
This retrospective study by Martyna Masternak et al. discusses the use of rectal water contrast transvaginal ultrasound (RWC-TVS) as a tool for assessing deep bowel endometriosis. The study explains how the procedure is minimally invasive, and how it involves filling…
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Menopause-management strategies for women with endometriosis.
By Selma Oransay
Menopausal hormonal therapy is the most effective treatment for menopausal symptoms, such as hot flushes, sweating, sleep disturbances, mood changes, and joint pain. Approximately 75% of all women experienced some degree of these symptoms, while 2-4% were diagnosed with endometriosis. Menopausal…
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Questionnaire Can Assess Patient-Centerdness of Endometriosis Care
By Özge Özkaya
European patients with endometriosis think that “reaching a diagnosis quickly” and “physicians demarcating the endometriosis complexity level which they can treat” are important aspects of their care, according to a new study published in the scientific journal Best Practice & Research…
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Melatonin for endometriosis-associated pain
By Eylül GÜN
Treatment options for endometriosis-associated pain include analgesics, hormonal therapy, and surgery. However, these treatments may be ineffective for some women, leading to a search for alternative approaches. Melatonin, a hormone involved in regulating sleep-wake cycles, possesses anti-inflammatory, analgesic, and anti-estrogenic…
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Spheroids: 3D-mini-models for Understanding Endometriosis
By Bahar Yuksel
The pathogenesis of endometriosis is not fully understood, and there is a need for better models to study the disease. Spheroids are 3D clusters of cells that mimic the structure and function of endometrial tissue. These mini models have several…
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New Model Can Help Understand How Endometriosis-Associated Ovarian Cancer Develops
By Özge Özkaya
Researchers from Japan and the US developed a new mouse model in collaboration, that can be useful to better understand how endometriosis-associated ovarian cancer develops. This new model can help to assess new treatment options for both diseases. The team…
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Limitations of current surgical classification systems for endometriosis.
By Selma Oransay
Many classification systems for endometriosis have been developed since the 1970s, and in a 2021 review, more than 20 of those systems were identified. The best-known and most frequently used are rASRM (revised American Society of Reproductive Medicine), the Enzian…
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Meningioma risk in women with endometriosis using Nomegestrol acetate
By Hale Goksever Celik
Women with endometriosis mostly suffer from symptoms such as chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility. Early diagnosis and management have importance as endometriosis impairs the quality of life and creates a serious social and economic burden. There are different…
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Endometriosis and Progesterone Resistance
By Selma Oransay
Progesterone resistance is the unresponsiveness of endometrium with subsequent dysregulation of the progesterone signaling pathway, and endometrial gene works. Progestins, on the other hand, are the first-line treatment choice, especially for long-term treatment of endometriosis. In the clinics, one-third of…
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Headaches Appear Years Before a Diagnosis of Endometriosis
By Özge Özkaya
Headache is associated with different forms of migraine, is related to pain, and often appears before diagnosis in women with endometriosis, according to a new study published in the scientific journal Reproductive Biomedicine Online. This knowledge can help ensure women with…
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Interleukin-35 expression in B lymphocytes: A new potential biomarker?
By Eylül GÜN
Regulatory T-cells (Tregs) and B-cells (Bregs) play a crucial role in establishing tolerance to self-antigens and suppressing immune activity. Therefore, in endometriosis, they are requisite for the endometriotic cells to survive outside the uterus. They suppress immune activity by producing…
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Unraveling the Role of Vascularization in Deep Endometriosis
By Bahar Yuksel
The systematic review by Simon G. Powell published in the journal Cells, analyzed 15 studies including 1125 women with deep infiltrative endometriosis up to March 2023 in several databases and found that angiogenesis plays a crucial role in the growth…
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Does ovarian endometrioma affect embryo aneuploidy rate in fertile women?
By Hale Goksever Celik
One of the most common clinical findings of women with endometriosis is the decline in fertility status. These women often benefit from in vitro fertilization methods to become pregnant. However, whether there is a detrimental effect of endometriosis on oocyte and…
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When to start ART after laparoscopic treatment of endometriosis?
By Selma Oransay
Laparoscopy combined with histopathologic confirmation of endometriosis is the reference standard for diagnosing endometriosis. Additionally, laparoscopic surgery is considered the most effective way to approach infertility induced by endometriosis. The surgical factors influencing the outcome of treating the infertility of…
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Nutritional recommendations for endometriosis patients
By Eylül GÜN
Diet and lifestyle factors have been implicated in the development and progression of endometriosis, in addition to genetic determinants. Piecuch et al. from Poland conducted a review study discussing the importance of different nutrients and nutritional recommendations in endometriosis. The…
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Novel Diagnostic Strategies for the Detection of Malignant Transformation of Endometriosis
By Bahar Yuksel
Endometriotic implants can grow on various organs and tissues in the pelvis, leading to pain, infertility, and other symptoms. Most cases of endometriosis are benign and there is a small risk of malignant transformation. The review conducted by Dr. Hiroshi…
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Improving the quality of life: The role of cognitive behavioral therapy after endometriosis surgery
By Eylül GÜN
Endometriosis and its symptoms have been associated with poor mental health and reduced quality of life. Cognitive behavioral therapy is recognized as an effective psychological treatment for managing depression, anxiety, and stress. Although surgery for endometriosis improves a patient's quality…
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The effect of glucocorticoid use on clinical pregnancy rates
By Selma Oransay
The preference to use glucocorticoids such as dexamethasone, prednisone, and methylprednisolone, along with IVF-ET cycles is due to the diminishing inflammatory response and suppressing immunity. Thus, while autoimmune diseases are suppressed with glucocorticoid administration, the success rate in the implantation…
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A rare and challenging site for endometriosis: Pancreas
By Eylül GÜN
Pancreas presents as a rare site for extragenital endometriosis. Gkegkes et al. performed a systematic review of the literature on pancreatic endometriosis. The article was published in the Jan-Feb 2023 issue of the journal Annals of Gastroenterology. A comprehensive search…
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Pregnancy and Endometriosis: The Hidden Risk of Gestational Diabetes
By Bahar Yuksel
Getting pregnant with endometriosis may be challenging. Besides, that pregnancy is a high-risk pregnancy. According to the recent meta-analysis led by Dr.Vigano, the risk of gestational diabetes increases in endometriosis patients. The study performed database searches on PubMed, Medline, Embase, and…
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The cost-effectiveness of different GnRH agonist regimes for progestogen-resistant endometriosis.
By Selma Oransay
Surgical and medical treatments are currently used to treat the pelvic pain caused by endometriosis. Respected guidelines recommend using progestins with or without estrogens as first-line medical treatment due to their safety, effectiveness, inexpensive, and tolerability. However, one-third to one-quarter…
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The effect of dienogest vs ethynyl estradiol/dienogest on quality of life in women with endometriosis
By Hale Goksever Celik
Women with endometriosis suffer from dysmenorrhea, dyspareunia, and chronic pelvic pain that diminishes the quality of their life. Both physical and mental components of quality of life have been affected by endometriosis-associated symptoms. There are several medical and surgical treatment…
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Exploring tissue origins and age characteristics in endometriosis
By Eylül GÜN
Despite its widespread occurrence, the precise factors leading to endometriosis and the nature of its symptoms remain uncertain. To better understand the disease and improve treatment, Leap et al. from the US and Austria explored the use of DNA methylation…
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Exploring the Potential Impact of Prenatal Testosterone on Endometriosis
By Bahar Yuksel
The exact causes of endometriosis still remain uncertain but emerging evidence suggests that prenatal factors may contribute to its development. In the review study by Bernard J Cresp et al, the authors discuss the hormonal environment during prenatal development and…
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Another New Approach Could Help Diagnose deep Infiltrating endometriosis
By Özge Özkaya
Elastography could help distinguish deep infiltrating endometriosis (DIE) nodules from non-endometriotic tissue at different locations, according to a new study published in Ultraschall in der Medizin - European Journal of Ultrasound. The potential of the technique in improving the diagnosis…
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The role of IL-33 and "T-regs" in lesion progression and fibrosis in endometriosis
By Eylül GÜN
It has been recognized that immune regulation likely plays a crucial role in endometriosis. Regulatory T cells (Tregs) are important immune regulators, and studies have linked Tregs to endometriosis development through signaling pathways involving TGF-β1 and PDGF. IL-33, an inflammatory…
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Ultrasonographic findings predicting parametrial deep endometriosis
By Selma Oransay
Transvaginal ultrasonographic evaluation is the primary imaging technique to rule out deep endometriosis. Although the International Deep Endometriosis Analysis Group (IDEA) published a consensus to standardize the nomenclature of ultrasonographic pelvic examination in women with suspected deep endometriosis, parametrial deep endometriosis…
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Deep Infiltrating Endometriosis and Adenomyosis have different genetic pathways
By Bahar Yuksel
It is still not defined whether adenomyosis is also a deep endometriosis component or not. In the study conducted by Marshall et al, the researchers compared the gene expression patterns between deep infiltrating endometriosis (DIE) and adenomyosis uteri in order…
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Endometriosis diet and the quality of life
By Hale Goksever Celik
Women with endometriosis suffer mainly from pelvic pain which results in a negative effect on the quality of life. Although several treatment options have been proposed, some endometriosis patients still have poor quality of life due to pelvic pain. Upon…
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Surgery for Deep Endometriosis
By Selma Oransay
In recent years, minimally invasive surgery has gained popularity, providing the best results in gynecologic cancers and deeply infiltrated endometriosis. With the help of a high-definition camera displayed on a TV monitor, the small structures are enlarged 4-7 times and…
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Neuroendocrine pathway in endometriosis-related infertility
By Eylül GÜN
Dr. Robert Taylor from Jacobs School of Medicine, University at Buffalo presented on the newly defined neuroendocrine pathway and its role in endometriosis-related infertility and how implantation and pregnancy establishment might be disrupted in endometriosis at the Annual International Medical Conference of…
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From inflammation to remission: The promising role of jun kinase inhibitors in endometriosis
By Eylül GÜN
Stephen Palmer from Baylor College of Medicine presented his speech at the Annual International Medical Conference of the Endometriosis Foundation of America held in New York on April 1-2, 2023. Dr. Palmer began his talk with a philosophy and a personal statement “Endometriosis is…
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The #Enzian classification, an essential tool for surgical management of severe endometriosis
By Hale Goksever Celik
The lecture entitled "The #Enzian classification, an essential tool for surgical management of severe endometriosis" was presented by Professor. Jörg Keckstein, from the University Ulm, Germany, at the Annual International Medical Conference of the Endometriosis Foundation of America held in New York on…
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Endometriosis disease modelling via induced pluripotent stem cells has been successful
By Nasuhi Engin Aydin
J. Julie Kim, S. Y. Hung Research Professor and Professor of ObGyn, Reproductive Science in Medicine, Northwestern University, Chicago, Illinois, has delivered a conference at the Annual International Medical Conference of the Endometriosis Foundation of America held in New York on April 1-2,…
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Insights into immune dysfunction in endometriosis - Chandrakant Tayade, DVM, PhD
By Bahar Yuksel
In his speech presented at the Annual International Medical Conference of the Endometriosis Foundation of America held in New York on April 1-2, 2023, Dr. Tayade talks about the relationship between endometriosis and the immune system. Dr. Tayade begins by emphasizing the significance of…
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Which surgery for deep endometriosis? Laparoscopic shaving or rectal resection?
By Selma Oransay
This keynote lecture entitled "Deep endometriosis: The place of laparoscopic shaving" was presented by Dr. Jacques Donnez, the director of the infertility research unit at the Catholic University of Louvain, Brussels, Belgium, at the Annual International Medical Conference of the Endometriosis Foundation…
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Preclinical organ-on-chip models of endometriosis lesions - Linda Griffith, PhD
By Özge Özkaya
Professor Linda Griffith, Professor of Biological and Mechanical Engineering and the director of the Center for Gynepathology Research at Massachusetts Institute of Technology gave a presentation about their preclinical organ on-chip models of endometriosis lesions at the 14th Annual International…
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Epigenetic defects of stromal cells in endometriosis and adenomyosis lead to estrogen sensitivity
By Nasuhi Engin Aydin
Serdar Bulun, MD, J.J. Sciarra Professor and Chair Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois has delivered a conference on “Endometriosis and adenomyosis: single-cell genome-wide approaches” at the Annual International Medical Conference of the Endometriosis Foundation…
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2023 MedicalConferance: Pros and cons of hormonal interventions for endometriosis - Sarah Berga, MD
By Bahar Yuksel
Prof. Berga, MD., who is the Chair of Ob&Gyn at Jacobs School Medicine and Biomed Sciences, presented this speech at the 2023 EFA Medical Conference. Dr. Berga explains that the primary goals of endometriosis treatment are to reduce pain and improve quality…
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Is there any advantage of addition of hysterectomy on deep endometriotic pelvic pain or on the quality of life?
By Selma Oransay
The addition of hysterectomy and salpingo-oophorectomy to the endometriosis excision surgery provided greater benefits when compared to excision surgery alone, according to the results of a comparison study that was recently published in the journal named "Facts Views and Visions in Obstetrics…
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Stem cells could be a good choice for therapeutic steps in many gynecologic disorders, including endometriosis
By Nasuhi Engin Aydin
Dr. Liu from the First Hospital of Jilin University, China, and colleagues from China and the USA have published their comprehensive review on the therapeutic gateways of stem cells in female genital tract disorders in a recent issue of Life…
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A self-diagnostic tool that predicts the likelihood of endometriosis
By Bahar Yuksel
Early diagnosis and treatment of endometriosis are crucial for preventing these negative outcomes, but the disease is often difficult to diagnose due to a lack of specific symptoms and reliable diagnostic tests. Goldstein et al. aimed to develop a machine-learning…
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The relationship between p53 gene polymorphism and endometriosis
By Eylül GÜN
The p53 gene is a well-known tumor suppressor gene that plays a crucial role in preventing cancer by regulating cell growth and division. Recent studies suggest that the p53 gene may also be linked to endometriosis. To investigate the relationship…
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Anti-IL-8 antibody ameliorates inflammation and fibrosis: A promising treatment for endometriosis
By Eylül GÜN
Endometriosis is a condition associated with chronic inflammation and fibrosis, and there are limitations and side effects with current treatments such as hormonal therapy and surgery. Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP1) are inflammatory cytokines that play a crucial…
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Antioxidant astaxanthin has promising effects on endometriosis-related infertility.
By Nasuhi Engin Aydin
Dr. Rostami and colleagues from the Tehran University of Medical Sciences, Iran, have published a pioneering clinical study on the effects of antioxidant astaxanthin supplementation in infertile endometriosis patients in the scientific journal named Frontiers in Endocrinology. A complicated network…
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Transvaginal Hydro laparoscopy for diagnosing and treatment of early stages of endometriosis
By Selma Oransay
Transvaginal hydro laparoscopy is a minimally invasive procedure that allows the exploration of the female pelvis. An obliterated Douglas pouch by a fixed retroverted uterus, an ovarian endometrioma greater than 2 cm, and the presence of deeply infiltrated endometriosis are…
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First-line surgery or first-line ART: A real challenge both for the clinicians and infertile women having DIE without colorectal involvement
By Hale Goksever Celik
Deep infiltrating endometriosis (DIE) is defined as the presence of endometriotic lesions over 5 mm in depth under the peritoneal surface. These women suffer from chronic pelvic pain, dysmenorrhea, dyspareunia, chronic pelvic pain, bloody or painful bowel movements, and infertility. There…
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Insights into the experiences of people with endometriosis during COVID-19 pandemic
By Selma Oransay
During the isolation of Covid 19 pandemic period, the most critical issue was healthcare access for patients. This was worse for patients who had chronic illnesses. Endometriosis is one of these chronic illnesses that need regular care, pain relievers, and…
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Serum Galectin-9 : A promising marker for endometriosis diagnosis
By Nasuhi Engin Aydin
Dr. Jarollahi and colleagues from Iran University of Medical Sciences, Tehran have published their research on serum levels of Galectin-9 as a noninvasive marker for endometriosis in the "Journal of Reproduction & Infertility". Endometriosis imposes a great challenge in the…
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Women With Chronic Pelvic Pain Have a Negative Experience With Doctors
By Özge Özkaya
Women with chronic pelvic pain have a negative experience with the healthcare system, according to a study by US researchers published in the International Journal of Obstetrics and Gynecology. This is the case regardless of whether or not they have…
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Does Endometriosis Surgery Increase the Rate of Pregnancy?
By Özge Özkaya
Surgery to treat colorectal endometriosis leads to a high rate of pregnancy following the operation, found a new study published in the Journal of Minimally Invasive Gynecology. The authors of the study said, “studies with a high level of evidence…
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Histopathologic examination always has the final word in tubal endometriosis
By Nasuhi Engin Aydin
Hai-Ning Jiao and coworkers from the Department of Obstetrics and Gynecology of Shanghai Jiao Tong University School of Medicine, China, reported the salient features of 30 tubal endometriosis cases in the World Journal of Clinical Cases. Tubal endometriosis is characterized…
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New adapted ESHRE guidelines for endometriosis.
By Selma Oransay
Eun Hee Yu and Jong Kil Joo from the Department of Obstetrics and Gynecology of Pusan National University School of Medicine, Republic of Korea, published a commentary on the 2022 ESHRE guidelines, referring to the representative changes and important updates in a recently…
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A Multidisciplinary Surgical Team Is a Must in Deep Endometriosis Surgery
By Özge Özkaya
Endometriosis must be managed by a team of multidisciplniary specialists, especially in case it causes damage to the digestive tract, according to a new study published in the journal Archives of Gynecology and Obstetrics. According to the authors, the presence…
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A review of multimodal imaging modalities for endometriosis.
By Selma Oransay
Since there is a lack of non-invasive biomarkers to diagnose endometriosis clinically, imaging techniques such as transvaginal ultrasonography and MRI have significant importance in preoperative endometriosis diagnosis. These imaging techniques allow appropriate surgical planning before laparoscopic excision, especially in deeply…
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Antiinflammatory lactoferrin molecule and antibody levels in endometriosis patients
By Nasuhi Engin Aydin
A Japanese clinical research team led by Dr. Kaya Mori-Yamanaka from Shiga University of Medical Science Hospital, Otsu, Shiga, Japan, published their pioneering study on the role of serum lactoferrin and anti-lactoferrin antibody levels in endometriosis in a recent issue of…
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Importance of dynamic cystoscopy for bladder endometriosis.
By Bahar Yuksel
Bladder endometriosis is a rare type of endometriosis but when diagnosed it requires extensive surgical procedures which include bladder resections. Thus, diagnosis and proper treatment are vital. In the study conducted in Brazil, the authors questioned the accuracy of applying…
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Laparoscopic resection of bladder endometriosis
By Selma Oransay
When we talk about deep-infiltrating endometriosis, one of the most commonly affected organs in the urinary tract is the bladder, with a prevalence of 80%. Bladder endometriosis can be defined as the existence of the endometrial glands and stroma inside…
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Current AAGL Staging System Not Good at Predicting Complexity of Endometriosis Surgery
By Özge Özkaya
The link between the stage of endometriosis as defined by the American Association of Gynecologic Laparoscopists (AAGL) and the level of surgical complexity is weak or moderate, according to a new study published in the Journal of Minimally Invasive Gynecology. …
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Postoperative pregnancy outcomes in women with deep infiltrating endometriosis
By Hale Goksever Celik
Subperitoneal invasion of endometriotic lesions exceeding 5 mm in depth is named "deep infiltrating endometriosis' and can be located on uterosacral ligaments, in the intestine, vagina, bladder, and ureter. Women with deep infiltrating endometriosis suffer from pelvic pain and infertility most…
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This time it is good to have this stress: Endoplasmic reticulum stress and endometriosis.
By Bahar Yuksel
Endometriosis is a hormone-based inflammatory disease. Cell-level therapeutic options are very popular when resistance to cell death capacity of endometriotic cells is on the table. In the review conducted by Hussein Riyadh Abdul Kareem Al‑Hetty et al, the authors summarized…
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Comparison of two surgical approaches for endometriosis.
By Selma Oransay
Endometriosis is one of the causes of infertility in women. But the pathophysiology of infertility caused by endometriosis is not yet clear. Hormonal disorders, abnormal peritoneal function, distorted pelvic anatomy, and multiple cesarean deliveries are among the accused. Dr. Li…
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Is there a way for a nonaddictive opioid for endometriosis pain?
By Bahar Yuksel
Endometriosis is a neuro-inflammatory disease whose current medical treatment is hormonal therapy. Given the side effects and the possible interactions between the opioid system and pain mechanisms, a new opioid medication might be promising. in the review conducted by Dr.Mechsner et…
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From Finland : How to increase health issues in endometriosis patients
By Nasuhi Engin Aydin
Dr. Henna-Riikka Rossi and associates from the University of Oulu, Oulu, Finland have published their recent prospective cohort study on possible existing comorbidities of endometriosis patients in the journal Fertility and Sterility. Endometriosis is an estrogen-dependent chronic ailment affecting about…
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Endometriosis awarness for the Gastroenterologists.
By Selma Oransay
Women with endometriosis can develop chronic abdominal pain and/or abnormal bowel habits more than eight times compared to women without endometriosis. For this reason, an undiagnosed patient with endometriosis may be referred to a gastroenterologist and remain in a situation…
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Comparison of different IVF stimulation protocols for pregnancy success in infertile endometriosis patients
By Hale Goksever Celik
Women with endometriosis may suffer from reproductive problems up to an incidence of 50%. Several pathophysiological mechanisms including anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis and sperm movements are the most responsible for the development of endometriosis-associated infertility.…
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Is alcohol a risk factor for endometriosis?
By Eylül GÜN
As complex and unclear as endometriosis pathogenesis is, the influence of environmental factors on the inflammation that underlies the pathogenesis of endometriosis has been thoroughly investigated. Lifestyle factors such as diet, caffeine, environment, smoking, and alcohol consumption have been explored…
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Hypoxia and endometriosis: A review of mechanisms
By Eylül GÜN
Various mechanisms have been suggested to explain the development of endometriosis lesions. One of these is hypoxia, which can induce changes in endometrial cells, but the exact mechanism is not yet clear. Zhou et al from China wrote a review…
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Is the pathogenesis of endometriosis hidden in immune-related gene profiles ?
By Nasuhi Engin Aydin
Yanan He and colleagues from the Department of Gynecology, Harbin Medical University, China have published their manuscript on potential immune markers in endometriosis in a recent issue of “Journal of Immunology Research” Pathophysiologic mechanisms involving endometriosis are complicated and have…
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GnRH Antagonists Can Effectively Reduce Endometriosis Pain
By Özge Özkaya
Oral gonadotropin-releasing hormone (GnRH) antagonists are effective in reducing pain associated with endometriosis in 12 weeks, according to a new study published in the scientific journal Archives of Gynecology and Obstetrics. The safety and efficacy of most drugs were dose-dependent…
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The effectiveness of acupuncture in the treatment of dysmenorrrhea
By Selma Oransay
Asymptomatic endometriosis does not adversely affect women's quality of life and mental health. But the quality of life of women with endometriosis who suffer endometriosis-related pelvic pain, dysmenorrhea, dyspareunia, and dysuria declines as they become more susceptible to anxiety and…
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Activities of cytotoxic cells in endometriosis
By Eylül GÜN
Immunological dysfunction is thought to be involved in the etiopathogenesis of endometriosis, leading to defective immunosurveillance and the growth of endometriotic lesions. In this pathway, reduced cytotoxicity of peripheral and peritoneal natural killer (NK) cells is seen as a contributing…
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Conventional IVF or ICSI: Which one is more accurate in endometriosis-related infertility?
By Hale Goksever Celik
Although the prevalence of endometriosis is 10-15% in the general population at reproductive age, it is diagnosed more frequently in infertile women with a prevalence of 25-40%. Although the exact mechanism explaining the association between endometriosis and infertility has not…
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The optimal endometrial preparation protocol in FET cycles of women with endometriosis.
By Selma Oransay
Endometriosis can create infertility and may require treatment with assisted reproductive technology (ART) to induce pregnancy. However, the current literature rarely discusses the optimal endometrial preparation protocol in thawed-frozen embryo transfer (FET) cycles for endometriotic patients. Dr.Jin. group from the Reproductive…
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How Can Endometriosis Care Be Improved?
By Özge Özkaya
Researchers identified 61 areas for improvement in endometriosis care based on the answers of endometriosis patients. Of these the top five areas of improvement were to train caregivers in order to develop their knowledge about endometriosis, to provide better management…
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Evaluation of the postoperative disability in women with endometriosis.
By Selma Oransay
Endometriosis is a chronic disease with a prevalence of 4,4% in women of reproductive age. It is also estimated that 23,8 of infertile women have endometriosis. Pelvic pain, dyschezia, dysmenorrhea, and dysuria are the symptoms of this disease that negatively…
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The most common gynecologic admissions to the emergency: Endometriosis and adenomyosis
By Hale Goksever Celik
Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Adenomyosis occurs when the endometrial glandular and stromal tissue grows into the muscular wall of the uterus, called the myometrium. Women having adenomyosis also…
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The emotions and experiences of women with endometriosis during and after pregnancy
By Eylül GÜN
It is well-known that endometriosis patients have a high rate of infertility and a hard time getting pregnant compared to women without endometriosis. Despite the belief that pregnancy can alleviate endometriosis symptoms, some studies have shown that women with endometriosis…
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Relation between hormone replacement therapy and postmenopausal endometriosis.
By Bahar Yuksel
The faith of endometriosis after oophorectomy with hysterectomy is unknown. It is clear that applying only a hysterectomy but leaving the affected tissue behind is not a solution for endometriosis-related symptoms. Either total clearance or leaving endometriotic tissues behind when…
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Endometriosis Seems to Increase the Risk of Preeclampsia
By Özge Özkaya
Women with endometriosis who conceive spontaneously, i.e. without the help of assisted reproductive technologies seem to be at a higher risk of preeclampsia, according to a new study published in the Journal of Minimally Invasive Gynecology. However, endometriosis does not…
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Economic burden while living with endometriosis.
By Bahar Yuksel
Endometriosis is a debilitating disease when all the symptoms are considered. Besides mental and physical effects, the economic burden is also a problem for the patients. In the study conducted by Josep Darbà et al, the costs of endometriosis have…
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Diaphragmatic Endometriosis: a Call for Awareness
By Nasuhi Engin Aydin
Dr. Pagano and colleagues from the Department of Gynecology and Obstetrics, University of Bern, Switzerland, have published a prospective cohort study on diaphragmatic involvement in endometriosis patients in a recent issue of “The Journal of Minimally Invasive Gynecology”. Endometriosis is…
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Iron and toxic environmental elements in ovarian endometriomas
By Selma Oransay
It is well-known that the growth of endometriotic lesions is estrogen-dependent and supported by inflammatory processes. In addition to oxidative stress, it is believed that several other factors, including chemicals and environmental factors, and genetic predisposition may play a potential…
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Women With More Severe Endometriosis Have Fewer Eggs
By Özge Özkaya
Severe endometriosis negatively affects ovarian response and the quality of oocytes and embryos, according to a new study published in JBRA Assisted Reproduction. However, the rate of fertilization does not seem to be affected by endometriosis stage. These findings could…
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Endometriosis-Associated Pain: The Role of Sensitization
By Eylül GÜN
As the most common symptom of the disease, endometriosis-associated pain (EAP) is experienced as dysmenorrhea, non-cyclical pelvic pain, and cyclical pain related to organ function. EAP is contributed to by different mechanisms, including local factors, peripheral sensitization, central sensitization, cross-sensitization,…
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Ultrasonographic Presurgical Staging and Classification of Endometriosis
By Selma Oransay
Laparoscopic surgery is the gold standard for diagnosing endometriosis, but a preoperative imaging procedure is strongly recommended. Transvaginal sonography by a skilled examiner is not inferior to MRI diagnostics regarding sensitivity and specificity in predicting the extension of deep endometriosis. …
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By Elisabetta KuhnMolecular Alterations in Ovarian Endometriosis
By Elisabetta Kuhn
Endometriosis is a benign disease with biological features characteristic of malignant tumors, such as invasiveness and migration abilities. In epithelial malignant tumors, it is believed that epithelial-mesenchymal transition (EMT), that is, the switch of an epithelial phenotype versus a mesenchymal…
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Sexual function in infertile women with PCOS and endometriosis
By Hale Goksever Celik
Women with endometriosis suffer from several symptoms and signs including dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility which have a detrimental effect on their quality of life. Sexual dysfunction also is a common problem for endometriosis patients due to complex…
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Transvaginal ultrasound or MRI for retroflexed uterus in endometriosis
By Nasuhi Engin Aydin
Dr Matsuda and colleagues from the Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan have published their study evaluating the effectiveness of transvaginal ultrasound on the diagnosis of uterine retroflexion in a recent issue of “Journal of Nippon…
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Imaging techniques for fallopian tubes
By Selma Oransay
The imaging techniques used for suspected fallopian tube pathology are ultrasound, hysterosalpingo-contrast-sonography, hysterosalpingography, computed tomography, and magnetic resonance imaging. Among several benign lesions that involve fallopian tubes, pelvic inflammatory disease, tubo-ovarian abscess, salpingitis isthmica nodosa, hydrosalpinx, tubal endometriosis, isolated fallopian…
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Do not underestimate the power of red blood cell evaluation in endometriosis
By Eylül GÜN
In an effort to develop an easy-to-use diagnostic marker, research has focused on the pro-inflammatory nature of endometriosis and the raised levels of inflammatory markers. The neutrophil-to-lymphocyte ratio (NLR) has emerged as one of these markers. Moreover, endometriosis has been…
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Gastrointestinal symptoms in colorectal deep endometriosis
By Eylül GÜN
The colon, particularly the recto-sigmoid is the most commonly involved area in deep endometriosis. These patients suffer from gastrointestinal symptoms almost as much as pelvic pain symptoms the most common being reported as frequent and painful defecation. Gastrointestinal symptoms may…
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Diagnostic criteria for uterosacral ligament involvement in endometriosis.
By Selma Oransay
Transvaginal ultrasonography is often used to diagnose endometriosis in suspected women due to its high resolution, low cost, and relatively low discomfort. Histologic confirmation of laparoscopically removed specimens is still the gold standard for appropriate diagnosis. The team led by…
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Scientific unfolding will lead new drug targets
By Nasuhi Engin Aydin
Drs. Dolmans and Donnez from academic institutions located in Brussels, Belgium, have published their comprehensive review on the current pathophysiological concepts in endometriosis with possible drug treatment potentials in the recent issue of a scientific journal named “Biomolecules”. As a…
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The "Painful Periods Screening Tool" Could Speed Endometriosis Diagnosis
By Özge Özkaya
The Painful Periods Screening Tool (PPST) is a useful tool for women with endometriosis, according to a new study published in the scientific journal Reproductive Sciences. The study's authors said that the tool “ facilitated communication between patients and providers…
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Endometriosis and the body perception
By Hale Goksever Celik
The most common endometriosis-associated symptoms are pelvic pain, dysmenorrhea, dyspareunia, and infertility. Women with endometriosis should be managed due to the significant impact of these symptoms on their quality of life. Body perceptions of these women are also affected depending…
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Adverse pregnancy outcomes and endometriosis.
By Selma Oransay
Inflammation plays a big role in the pathogenesis of endometriosis with the release of inflammatory cytokines, angiogenic imbalance, and oxidative stress. These pathways are also common features of severe maternal morbidity. Severe maternal morbidity is life-threatening, causing cardiac and renal…
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Creating a reliable indirect immunofluorescence protocol as a promising diagnostic tool for endometriosis
By Eylül GÜN
Owing to its inflammatory nature, endometriosis results in the overproduction of reactive oxygen species (ROS) which disrupt the cellular functions and eventually lead the cell to apoptosis and cell cycle arrest. Senescence, the natural state of irreversible cell cycle arrest,…
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Uterine leiomyomas and endometriosis may coexist yielding important clinical implications
By Nasuhi Engin Aydin
Drs. Uimari, Nazri, and Tapmeier from Finland, the UK, and Australia have published their comprehensive review on the comorbidity of endometriosis along with uterine leiomyomas in the medical journal “Frontiers in Reproductive Health”. The comorbidity of uterine leiomyomas and endometriosis…
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Rare but important entity: perineal endometriosis
By Nasuhi Engin Aydin
Dr. Zhu and colleagues from Peking Union Medical College Hospital have published their retrospective research on "surgically treated perineal endometriosis cases" in a recent issue of BMC’s Women’s Health. Perineal endometriosis is a rare type of endometriosis accounting for at…
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Gestrinone May Be Safe and Effective in Treating Endometriosis Symptoms
By Özge Özkaya
Gestrinone seems to be safe for the treatment of endometriosis, according to a new study published in the scientific journal Archives of Gynecology and Obstetrics. It also may be more effective than danazol and other medical treatments. However, these findings…
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Molecular and cellular mechanisms of fibrogenesis in endometriosis
By Selma Oransay
Endometriosis lesions are characterized by endometrium-like cell proliferation, invasion, and oxidative stress associated with inflammation and neoangiogenesis. Fibrosis, which occurs due to these events, causes chronic pelvic pain depending on the location and the severity of endometriosis. For the purpose…
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How accurate is ultrasonography in evaluating deep infiltrating endometriosis?
By Eylül GÜN
Deep infiltrating endometriosis (DIE) appears to be the most severe form of endometriosis comprising 15-30% of all endometriosis patients. The difference in the presentation of the lesions ranges from simple adhesions to infiltrative nodules. Even though there is no consensus…
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Do combination GnRH antagonists improve endometriosis-associated pain?
By Hale Goksever Celik
Endometriosis is a chronic inflammatory disease with a broad spectrum of pain symptoms such as dysmenorrhea, dyspareunia, and chronic pelvic pain. It has been understood in light of scientific evidence that endometriosis results in diminished quality of life in these…
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Which parameter is useful in predicting cardiovascular disease risk in perimenopausal endometriosis patients?
By Eylül GÜN
Cardiovascular disease is known to be the leading cause of death among women worldwide. Studies have shown that postmenopausal women are at a greater risk as well as women who undergo premature menopause proving the effect of hormonal imbalances on…
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Ovarian endometriomas, ovarian reserve, oocyte quality and IVF/ICSI outcomes
By Selma Oransay
Surgery and assisted reproductive technology (ART) are the preferred treatments for endometrioma in infertile patients. When ART is considered, surgery may seem to have no advantages, as it may not improve pregnancy outcomes and may carry the risk of decreasing…
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Deep Endometriosis Surgery and Women’s Quality of Life
By Özge Özkaya
The physical and social functions as well as the overall physical health is worse than normal among Spanish women who underwent surgery for deep endometriosis, reported a new study published in the Journal of Clinical Medicine. The bodily pain, emotional…
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Uterine agenesis patients may have endometriosis too
By Nasuhi Engin Aydin
Dr. Steinmacher and colleagues at the Tuebingen University Hospital, Germany have published their unique study on a series of patients with congenital Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome in a recent issue of the “Journal of Clinical Medicine”. The absence uterus and upper…
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Minimally Invasive Surgery Improves the Quality of Life of Women With Deep Infiltrating Endometriosis
By Özge Özkaya
Minimally invasive surgery improves the quality of life of women with deep infiltrating endometriosis two years after the operation, according to a new study published in the Journal of Clinical Medicine. The results are similar between conservative and total surgery.…
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Breastfeeding Seems to Protect Both Mother and Baby From Endo
By Özge Özkaya
Breastfeeding seems to decrease the risk of endometriosis, according to a new study published in the scientific journal Breastfeeding Medicine. Similarly, there seems to be a negative association between ingesting breast milk and the risk of developing endometriosis later in…
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Efficacy of Uterine Artery Blockage in Endometriosis Management
By Nasuhi Engin Aydin
Dr. Li Ma and associates from Liaoning, China have published their results of a computerized database search on the role of uterine artery embolization in endometriosis in a recent issue of the periodical “Computational Intelligence and Neuroscience”. Currently, the management…
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Opioid use following operation for endometriosis or pelvic pain
By Hale Goksever Celik
Women with endometriosis have pain in the form of dysmenorrhea, dyspareunia, and chronic pelvic pain, and they have a diminished quality of life depending on the severity of pelvic pain. Opioids have been preferred in many patients suffering from pain,…
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What causes pelvic pain? Androgens or estrogens?
By Selma Oransay
A comparison between women and men reveals that women suffer more pelvic pain. This reality raises the possibility of the pain-relieving effect of testosterone or androgens. It would be a wise solution to investigate how androgens affect pain at different…
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Endometriosis Hospitalization Trends in Spain
By Eylül GÜN
According to the general assumption, one in every ten women is believed to have endometriosis. However, recent literature shows a big difference in the prevalence rates ranging from 1 to 5%, likely because most cases remain undiagnosed. The need for…
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Anhedonia and its relation to endometriosis as a sole symptom
By Eylül GÜN
"Anhedonia may be defined as a broad category of hedonic function deficiencies, including diminished motivation or enjoyment capacity. It has been an area of interest for a long time in psychiatric disorders and has been crucial in some diagnoses such…
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Obstetric Outcomes of Pre-pregnancy Endometriosis Surgery
By Selma Oransay
Endometriosis may be associated with poor pregnancy outcomes, including placenta praevia, preterm birth, premature prelabour rupture of membranes, obstetric hemorrhage, gestational hypertensive disorders, fetal growth restriction, and perinatal death. Some authors have attempted to demonstrate a causal relationship between endometriosis…
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Foreseeing what will be seen on laparoscopy
By Bahar Yuksel
Endometriosis diagnosis still relies on preoperative prediction and its confirmation by taking biopsies. Thus, a prediction model for forecasting what would be waiting for the surgeon and the patient will be promising to get prepared. In the study conducted…
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Scientists Try to Understand Consequences of Genetic Changes in Endometriosis
By Özge Özkaya
The protocol of the "Endometriosis Research Queensland Study" has been published in the scientific journal BMJ Open. The aim of the study is to collect endometrial tissue associated with the disease and chart its genetic architecture. This way, the researchers aim to…
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Antimicrobial agent ornidazole yields promising effects in an animal model of endometriosis
By Nasuhi Engin Aydin
Xiaoduo Qin and collaborators from Chinese medical centers, have published their results on the role of ornidazole using an experimental rat model in a recent issue of the periodical “Gynecologic and Obstetric Investigation”. Progression of endometriotic foci depends on the presence…
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The Delay in Endometriosis Diagnosis Is Huge
By Özge Özkaya
Eleven years pass on average in Italy for a woman to get diagnosed with endometriosis from when she starts having symptoms. This delay can even be even longer (4 more years) if the symptoms appear before a woman is age 20.…
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Non-hormonal medication for endometriosis-associated pelvic pain
By Selma Oransay
The thought of benefiting from non-hormonal therapy in endometriosis pain is based on the pathophysiological findings that include angiogenesis, fibrosis, the presence of inflammatory cytokines and immune cells, apoptosis, and stem cell theory. But the effect of this treatment in…
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Epigenetic changes in endometriosis: A new target area for therapy
By Eylül GÜN
Epigenetics is the heritable genetic modifications and changes in chromosomes without alterations in the DNA sequence. Numerous mechanisms, like DNA methylation and RNA editing to mention a couple, have been discovered as epigenetic alterations that are triggered by environmental factors.…
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Embryo implantation and endometriosis
By Bahar Yuksel
Infertility is one of the main symptoms of endometriosis. And unfortunately, monthly fecundity rates decrease from 15% to 2-10% for women with endometriosis. The reason for these decreases is controversial and still not known whether it is because of impaired…
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Does endometrioma size have an effect on IVF/ICSI outcomes?
By Hale Goksever Celik
Assisted reproductive technologies including IVF/ICSI can be suggested as the therapeutic option in women with endometriosis-associated infertility. In literature, there is a controversy regarding the influence of endometrioma size on IVF/ICSI outcomes. The group led by Drs Chapron and Santoulli…
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Endometriosis Care Is More Patient-Centered for age older than 35
By Özge Özkaya
Women younger than age 35 receive endometriosis care in a less patient-centered manner compared to older women, found a new study published in the Journal of Obstetrics and Gynecology. This finding underscores the importance of improving endometriosis care, especially for…
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Deep lateral parametrial endometriosis nerve-sparing surgery
By Selma Oransay
Dr. Kanno et al. from the Department of Obstetrics and Gynecology of Kurashiki medical center, Okayama, Japan recently published a deep lateral parametrial endometriosis case report in the journal named Fertility and Sterility. The aim is to demonstrate the technical and…
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TSH receptor antibodies show promising results in the diagnostic workup of endometriosis
By Nasuhi Engin Aydin
Dr. Svensson with collaborators from the Swedish Lund University has published their results on the possible role of TSH receptor antibodies as biomarkers in endometriosis diagnosis in a recent issue of “European Journal of Obstetrics & Gynecology and Reproductive Biology”.…
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How beneficial is colorectal surgery for patients with deep endometriosis?
By Eylül GÜN
In cases of deep endometriosis, which causes more severe pain and gastrointestinal symptoms, the patient's quality of life and fertility outcomes are negatively affected. Surgical intervention is thought to be the optimal treatment method in colorectal deep endometriosis cases, however,…
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Postoperative serum markers to predict serum AMH recovery following endometriosis surgery
By Hale Goksever Celik
Women with endometriosis seek treatment including ovarian cystectomy, because of symptoms that reduce their quality of life. Ovarian cystectomy using laparoscopic or robotic devices is the preferred therapy. However, it has been shown in the literature that ovarian reserve is…
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Web-based resource to improve menstrual health awareness
By Selma Oransay
Many women consider "menstrual pain" a normal part of being female, and do not seek medical help but rather use self-management methods such as heat, rest, and analgesics. They are often unsure which self-management strategies are effective or what the…
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Exposure to toxic metals and the risk of endometriosis
By Selma Oransay
Mercury, lead, and cadmium are the best-studied heavy metals for several adverse effects on the human reproductive system. Mercury can induce DNA damage, oxidative stress, and mitochondrial dysfunction, and lead exposure is associated with menstrual disorders, preterm birth, and miscarriage.…
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Time to change out taboos about the radiologic evaluation of scar endometriosis
By Bahar Yuksel
Scar endometriosis is one of the rare forms of endometriosis. According to traditional belief, it has always been evaluated radiologically on menstruation days. In the study conducted by Balaban et al, the authors compared the differences in lesions according to…
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The management of diaphragmatic endometriosis
By Selma Oransay
Thoracic endometriosis is a rare disease, and it is likely to have been underdiagnosed and underreported. Optimal diagnostic testing and management options are yet to be determined. Imaging for thoracic endometriosis is still in its infancy, and MRI only helps to…
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Understanding what we see: endometriosis laparoscopic appearance and microscopic verification
By Nasuhi Engin Aydin
Chia-Sui Weng and colleagues from the Mayo Clinic, USA have published their results on laparoscopic appearances and microscopy of endometriotic lesions in “The Journal of Minimally Invasive Gynecology”. Even though the diagnosis of endometriosis has evolved greatly with advanced imaging…
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Rhein usage in endometriosis: A potential new therapeutic agent
By Eylül GÜN
The invasive nature of endometriosis has prompted scientists to find preventative and curative methods. The progression and proliferation of endometriotic lesions are being studied extensively. As one of the agents used in Chinese herbal medicine for inflammatory disorders, rhein is…
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Endometriosis and the possible mechanisms of pain.
By Selma Oransay
The most common clinical symptoms of endometriosis are chronic pelvic pain and infertility. It is often not enough to treat pain symptoms with hormonal therapy or a surgical approach. Moreover, the stage of endometriosis has weakly associated with the amount,…
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Organizing structural protein Ezrin and its active form in endometriosis biopsies
By Nasuhi Engin Aydin
Dr. Alessandra Peloggia and colleagues from Brazil have published their results on immunostaining of Ezrin protein and its phosphorylated active form in endometrial tissues in a recent issue of “Clinics” Possible factors on endometrial cell implantation and proliferation in the…
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Endometriosis and the cumulative live birth rate in IVF cycles.
By Hale Goksever Celik
Infertility is one of the symptoms encountered in up to 40-50% of women with endometriosis. There are several pathophysiological theories suggesting the development of endometriosis-associated infertility. Assisted reproductive technology (ART) using in vitro fertilization and embryo transfer (IVF-ET) has been…
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Taller Girls More Likely to Have Recurring Endometriosis
By Özge Özkaya
Adolescents who are taller and have three or more lesions are at a higher risk of endometriosis recurrence following surgery, according to a new study by Chinese researchers published in the Journal of Obstetrics and Gynaecology. They should, therefore, be…
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The dilemma of autophagy and its role in endometriosis
By Eylül GÜN
Autophagy is a mechanism for cell survival under metabolic stress that involves the degradation and recycling of intracellular components. Multiple genes actively control this process. Among these, the initiation stage of autophagosome formation is regulated by the gene Beclin-1 and…
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Endometriosis and Body Image
By Özge Özkaya
Endometriosis has a negative effect on health-related quality of life and body familiarity according to a new study published in the Journal of Psychosomatic Research. Based on this finding, the authors of the study recommend that body familiarity should be…
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A prediction model to identify endometriosis during routine ultrasound .
By Selma Oransay
. Ureterolysis is an advanced surgical technique that involves dissection of the ureter from pelvic brim to the ureteric tunnel to avoid injury or freeing the ureter from endometriotic lesions. This manipulation usually requieres advanced surgical training and skill. In…
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T-cell-targeted immunotherapy and immune checkpoint inhibitors for the treatment of endometriosis
By Nasuhi Engin Aydin
Dr. Monika Abraimuk and colleagues from Poland published their review on "the importance of immunity in endometriosis" in a recent issue of the medical journal “Cellular Signaling”. A great challenge in contemporary medical issues is endometriosis which still lacks a…
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How do the couples feel when dealing with endometriosis?
By Eylül GÜN
The effects of endometriosis on the patients' psychosocial well-being are well known. However, not many studies have investigated how it impacts the well-being of partners and couples. A few studies focused on the male perspective of the disease, whereas some…
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Parametrial endometriosis and postoperative voiding dysfunction.
By Selma Oransay
Parametrium constitutes a complex connective tissue containing blood vessels, the ureter, and the inferior hypogastric plexus, that extends from the lateral surface of the cervix and vagina to the lateral pelvic wall. Parametrial endometriosis may involve the vessels, nerves, and…
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The association between severe endometriosis and venous thromboembolism
By Hale Goksever Celik
For clarifying the issue of whether endometriosis patients are at risk for venous thromboembolism due to both their local immune and inflammatory responses and hormonal treatments, Wiegers et al, from the Netherlands, published an explorative cohort study entitled “Risk of…
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Researchers Develop New Mouse Model of Endometriosis
By Özge Özkaya
Researchers from China developed a new mouse model to study endometriosis that could help researchers better understand the molecular mechanisms that lead to the development of endometriosis and develop potential new treatments for the disease. Even though many animal models…
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Do endometriosis patients have increased risk of stroke?
By Nasuhi Engin Aydin
Dr. Leslie V. Farland and colleagues from the University of Arizona, published their prospective research on the risk of stroke in women with laparoscopically confirmed endometriosis in a recent issue of a scientific journal named “Stroke”. Endometriosis is a chronic…
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Pelvic pain characteristics in young girls with endometriosis.
By Selma Oransay
The occurrence of severe and frequent pelvic pain in young women is a piece of evidence that endometriosis begins and develops at an early age. Two-thirds of women with endometriosis who were diagnosed in their adulthood reported the onset of…
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Endometriosis Prediction by "Machine Learning"
By Selma Oransay
To develop a predictive model for endometriosis and to re-assess the contribution of known risk factors, Blass et al. from the Hebrew University of Jerusalem, Jerusalem, Israel used the data of the UK biobank by machine learning-based models. They compared and…
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Placenta Previa More Common Among Pregnant Women With Endometriosis
By Özge Özkaya
Endometriosis is associated with a higher risk of placenta previa, according to a new study published in the scientific journal Reproductive Sciences. This is the case whether the women became pregnant following in vitro fertilization (IVF). Moreover, for women with endometriosis…
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Vitamin C as a possible therapeutic agent in endometriosis
By Eylül GÜN
A rather toxic environment is generated with the production of reactive oxygen species by the immune cells in endometriosis. The anti-oxidant metabolism is also altered which results in a state of oxidative stress. As a potent antioxidant, Vitamin C has…
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A call for mast cells from endometriotic lesions
By Bahar Yuksel
Endometriosis is a well-known hormonal-dependent inflammatory disease. But what type of inflammatory cells is responsible, and when does estrogen take part, are questions that have not been answered yet. In the study conducted by Alison McCallion et al, the role…
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Fibrosis is not only a histological finding in endometriosis
By Eylül GÜN
Endometriosis remains to be an active subject of research with its complex pathophysiology and the indistinct mechanisms that cause the proliferation and progression of the lesions. Besides the already known characteristics of the disease, there is strong evidence to support…
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Study Identifies Factors Associated With Risk of UrinaryTract Endometriosis Recurrence
By Özge Özkaya
Being younger than age 25 and having an autoimmune disease are significant predictors of the recurrence of urinary tract endometriosis after surgery according to a new study published in the Journal of Minimally Invasive Gynecology. Adjuvant hormonal therapy, on the…
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To Remove the Ovary(ies) or Not During Hysterectomy for Endometriosis
By Selma Oransay
Some surgeons prefer empiric bilateral salpingo-oophorectomy during the hysterectomy of women with endometriosis based on the knowledge that endometriosis is stimulated by endogenous estrogens, as leaving the ovaries in situ may increase the possibility of endometriosis recurrence and pelvic pain.…
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Coexistence of endometriosis and cardiovascular diseases
By Hale Goksever Celik
The most common presenting complaints are mainly pelvic pain and infertility, most of which relate to the menstrual period. Affected women demand therapy for these symptoms of endometriosis, notably pelvic pain. Several theories have been proposed to explain the development…
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An important matter to revise: Immune system changes in endometriosis
By Eylül GÜN
Endometriosis is a multifactorial disease with unclear and obscure pathogenetic mechanisms. In their review, Chopyak et al. revised the immunopathogenic pathways that are proven and/or thought to be responsible for disease development and progression. The article was published in the…
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Endometriotic cyst fluid and the postoperative recurrence of endometriosis
By Nasuhi Engin Aydin
Dr. Xinxin Xu and colleagues from the Department of Obstetrics and Gynecology, School of Medicine, Zhejiang University, China, published their research on the viability of endometrial cells in ovarian cyst fluids in a recent issue of “Journal of Ovarian Research”.…
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Transvaginal Ultrasound Could Be Sufficient to Properly Diagnose Deep Endometriosis and Ovarians Endometriomas
By Özge Özkaya
Following the International Deep Endometriosis Analysis consensus can improve the accuracy of transvaginal ultrasound to diagnose ovarian endometriomas and deep infiltrating endometriosis, according to a new study published in the scientific journalUltrasound in Obstetrics & Gynecology. “ (…) at this…
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Endometriosis and environmental factors
By Selma Oransay
The estrogen-dependent nature of endometriosis has generally led to search endocrine-based causes. Especially, polychlorinated biphenyls, dioxins, and Dietilstilbesterol are the most studied chemicals in the literature. Interesting data that needs confirmation in the future also suggest a link with night…
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Fallopian tube occlusion in infertile women with endometriosis
By Hale Goksever Celik
Women with endometriosis suffer from fertility problems with an incidence of 40-50%. Among the pathophysiologic mechanisms resulting in impaired fertility in women with endometriosis, distorted pelvic anatomy due to adhesions, impaired follicular quality-quantity, dysfunction of tubal peristalsis, and implantation problems…
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The Oocyte Quality in Ovarian Endometriosis
By Selma Oransay
Endometrioma is the ovarian involvement of endometriosis affecting up to 44% of women diagnosed with the disease. Owing to the anatomical locus, ovarian endometriosis may impair folliculogenesis and oocyte competence, differing from other forms of endometriosis. When investigating the relationship between…
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The effects of resveratrol on endometriotic cells
By Eylül GÜN
The current treatment methods for endometriosis still carry recurrence risks and side effects from medications. Herbal medicine has been investigated and used as an additional alternative method. Derived from several plants and found in some dietary sources, resveratrol is a…
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The best method for the diagnosis of endometriosis: SEE and BELIEVE
By Eylül GÜN
Deciding on the best diagnostic procedure for endometriosis patients has been a recent subject of debate. While some clinicians believe non-invasive methods such as imaging and symptom-based treatment should be the choice in the diagnosis, some believe the best method…
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Validity of Magnetic Resonance Imaging for Deep Pelvic Endometriosis.
By Selma Oransay
Video laparoscopy has become a valuable tool for diagnosing and managing endometriosis in recent years. In cases associated with deep infiltrating endometriosis, the need for a non-invasive diagnostic method before laparoscopic evaluation paves the way for using MRI. The use…
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Gluten Intake May Not Have an Effect on Endometriosis
By Özge Özkaya
Carbohydrate quality and certain types of fiber such as total vegetable and cruciferous vegetable fiber seem to be associated with endometriosis in women before menopause, found a new study published in the Journal of Nutrition. According to the study, it…
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Start exercising for pain relief
By Bahar Yuksel
Physical exercises have always been suggested for chronic pain-related diseases as well as endometriosis. However, the effect of exercise and the frequency that is effective on pain relief is unknown. In the study conducted by Ipek Ensari et al, a…
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Combined "Platelet-to-lymphocyte ratio and CA125" may be promising predictor for adhesions
By Nasuhi Engin Aydin
Drs. Guo & Zhang from the Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China published their manuscript on the importance of combined "platelet-to-lymphocyte ratio and CA125 level" as a biomarker of endometriosis in a recent…
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Sex Education For The Sexual Quality Of Life
By Hale Goksever Celik
The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Decreased quality of life due to pelvic pain, dyspareunia, and psychological conditions such as anxiety and depression can lead to sexual dysfunction in women with endometriosis.…
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Estradiol metabolism, endometriosis and migraine
By Bahar Yuksel
Endometriosis and migraine are the leading pain diseases of women of reproductive ages. As both are known to be induced by hormonal changes, in the review conducted by Joy-Fleur van der Vaart et al, the authors aimed to find out the…
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Time has come to learn more about endometriosis and take action!
By Eylül GÜN
It has been a long time since endometriosis was defined. Extensive population studies have shown that around 10% of women suffer from this condition. Depending on its severity, it alters the various functions of the body and causes the patients…
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Does the timing of endometriosis diagnosis affect optimal infertility treatment?
By Selma Oransay
Based on a retrospective population-linked data study in "Human Reproduction", the ESHRE journal club featured a detailed discussion with 50 participants, patients’ representatives, and experts (Paola Vigano´, Mathew Leonardi, Thomas D’Hooghe, Louise Hull), together with the authors of the original article, mainly…
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New Endometriosis Self-Assessment Tool Could Help Women Seek Timely Medical Attention
By Özge Özkaya
Researchers from Korea developed a self-assessment tool that may allow women to determine their risk of endometriosis. They described the tool in an article they published in the scientific journal Obstetrics & Gynecology Science. “The devised tool appears valid and…
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Genomic evidence: The recognition of endometriosis as an inflammatory systemic disease
By Nasuhi Engin Aydin
Dr. Bao and associates from Shangai-China published a new article on the genomic features of endometriosis that could yield information on its inflammatory basis and possible therapeutic potential in a recent issue of “Frontiers ın Immunology”. Endometriosis is a systemic process…
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Evaluation of retrocervical and parametrial deep endometriosis by detailed ultrasonography
By Selma Oransay
The accuracy of ultrasonographic diagnosis of deep endometriosis in the retrocervical and parametrial areas may be poor due to the variable morphology of endometriotic lesions, the complex structure of the posterior parametrial compartment, and the difference in examiners' experience level.…
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Research Identifies Blood Proteins Associated With Endometriosis in Adolescents
By Özge Özkaya
Proteins related to angiogenesis or the formation of new blood vessels and cellular migration are enriched and more active in the blood of adolescents with endometriosis compared to healthy controls. These are the findings of a new study published in…
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Chasing gold to find endometriosis.
By Bahar Yuksel
Endometriosis is a disease that doesn’t have a proper preoperative diagnostic test. Thus, animal models to study endometriosis are vital to show the effects of drugs and the effects of the disease on the body. In the study conducted by…
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Endometriosis-associated infertility: How to manage?
By Hale Goksever Celik
Although the underlying reason for endometriosis has not been fully established, there is an association between endometriosis and infertility. Endometriosis is thought to be involved in 40-50 percent of infertility cases. However, natural conception can still occur even in women…
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Is it possible to reduce pain by diet in endometriosis?
By Eylül GÜN
Endometriosis-related pain is one of the most common symptoms of endometriosis that significantly affects the patient's quality of life. The peripheral and central sensitization, caused by chronic inflammation activation, may result in referred pain. The pain perception was shown to…
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Would it be possible to diagnose endometriosis from a vaginal swab?
By Nasuhi Engin Aydin
Ectopic endometrial tissues with new vessel formations in an inflammatory background have a component of mast cell-derived exosomal tRF-Leu-AAG-001 promoting inflammation and angiogenesis. This information is according to the paper published in a recent issue of the journal “BMC Women’s Health”,…
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A new potential therapeutic target in endometriosis: Galectin-3
By Eylül GÜN
The endometrial cells migrate and attach to the peritoneal surface according to the most widely accepted retrograde menstruation theory in endometriosis development. Given that only 10% of women have endometriosis, it is thought that some additional factors contribute to the…
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The role of oxidative stress on endometriosis symptomatology
By Bahar Yuksel
Endometriosis is not only a hormonal disease, but it is also an inflammatory illness provoked by hormones. In the review conducted by Hossein Ansariniya et al., from Iran, the relation between oxidative stress, free radicals, free iron, and the development of…
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How do regional differences affect the incidence rates of endometriosis?
By Eylül GÜN
Despite all the ongoing work for endometriosis awareness, it continues to be an underdiagnosed disease. Several different factors are responsible for this. The variations of its symptomatology play a big part as well as the lack of understanding of the…
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Fertility assessment and surgical approach in endometriotic patients.
By Selma Oransay
The prevalence of endometriosis is around 50-70% in women with pelvic pain, and it has been reported as 50% in patients with infertility. Severe adhesive disease associated with advanced endometriosis is a cause of fertility impairment. The relationship between endometriosis…
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The effect of chronic endometritis on pregnancy outcomes in infertile women having minimal/mild endometriosis
By Hale Goksever Celik
Endometriosis is an estrogen-dependent disease that is frequently diagnosed in reproductive-aged women. Infertility can be associated with endometriosis in these women depending on several pathophysiologic mechanisms such as anatomic distortion, and implantation failure. Thus pregnancy rate is so important, especially…
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Understanding the expression of endometriosis-related pain: A barrier to overcome
By Eylül GÜN
It is difficult to describe the feeling of pain, one of the most important symptoms of endometriosis because it is subjective. Endometriosis-related pain is proven to be underestimated by some clinicians resulting in the patient getting a late diagnosis. It…
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Postoperative outcomes of deep intestinal endometriosis surgery.
By Selma Oransay
Invasion of endometriotic lesions to the bowels' mucosal and/or muscular levels is called intestinal deep endometriosis. These lesions are most frequently found in the rectosigmoid colon, followed by the rectum, ileum, appendix, and caecum. The optimal surgical approach to intestinal deep…
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Soluble CD90 : a potential serum biomarker in endometriosis
By Nasuhi Engin Aydin
Dr. Bochev and colleagues from several medical centers in Bulgaria published their research on the role of a possible serum biomarker in diagnosing endometriosis in a recent issue of the journal named “Disease Markers”. The definitive diagnosis of endometriosis, an…
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Immune cells in peritoneal endometriosis
By Nasuhi Engin Aydin
Dr. Burcu Ersoy and associates from The University of Sydney, Australia, published their interesting study on surgically removed peritoneal endometriosis tissues in the journal named "F&S Science". It is still a dilemma how ectopic endometrial tissues attach to the peritoneum, persist…
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Ankylosing Spondylitis and Endometriosis
By Hale Goksever Celik
There are several theories contributing the development of endometriosis: one of the proposed pathophysiological mechanisms is the abnormality in immune and inflammatory system. Several immunologic diseases coexist with endometriosis depending on the common immunologic characteristics such as Tumor necrosis Factor…
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The accuracy of transvaginal ultrasound and magnetic resonance imaging for deep urinary tract endometrisis.
By Selma Oransay
The prevalence of urinary tract endometriosis is 19-53% in patients within deep infiltrating endometriosis cases. The bladder and ureteral are the most common sites of the involvement. While preparing a radical surgery for a patient with deep endometriosis, the diagnosis…
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A search for a marker to show the malignancy risk of endometriomas
By Bahar Yuksel
The premalignant features and precursors that show the malignant potential in endometriomas are not well-known. In the systematic review conducted by Ludovica Bartiromo et al, the markers for malignant transformation have been analyzed and recently published in a recent issue of…
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Endometriosis in transmasculine people
By Eylül GÜN
“Transmasculine” refers to people who were assigned female at birth but later identify themselves with masculinity. If they choose to transition to the male gender, they are then prescribed long-term testosterone and some may want to undergo a hysterectomy as…
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Chronic pelvic pain and endometriosis
By Selma Oransay
Patients may have an average of 7 clinical visits before being diagnosed with endometriosis. Understanding chronic pain conditions including endometriosis-associated pain, and developing chronic pelvic pain benefits the management of the patients. The role of central sensitization, comorbid conditions, and…
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Who Is Diagnosing my Endo?
By Özge Özkaya
It is possible to acquire the skills necessary to diagnose endometriosis lesions as well as adenomyosis using three-dimensional rectosonography after a short learning period in an expert radiology center. This is according to a new study by French researchers published…
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Is it possible to predict recurrence after ovarian endometriosis surgery?
By Eylül GÜN
The current treatment methods for endometriosis both have their flaws: the medical treatment is sometimes ineffective and the surgical treatment comes with a high rate of recurrence. Even though new surgical modalities have been developed, laparoscopic cyst removal continues to…
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The association between inflammatory cytokines and fertility in women with endometriosis
By Hale Goksever Celik
Women with endometriosis suffer not only from a broad spectrum of symptoms including pain including dysmenorrhea, dyspareunia, and chronic pelvic pain but also fertility problems. Endometriosis-associated infertility develops depending on a combination of several mechanisms such as distorted pelvic anatomy,…
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The clearance system is defective for women who develop endometriosis
By Bahar Yuksel
Endometriosis is both a hormonal and an immune disease thus overcoming the immune response by improving the underlying mechanism would help fight the disease. In the study conducted by Dr.Guidice group at the University of California San Francisco, San Francisco, CA,…
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Surgery Improves the Sex Life and Sleep of Women With Endometriosis
By Özge Özkaya
Endometriosis surgery improves patients’ quality of life, sexual function, and sleep confirms a new study by Turkish researchers published in the scientific journal Archives of Gynecology and Obstetrics. According to the first author Dr. Belfin Nur Arici Halici of the…
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Does inhibiting the formation of the new blood vessels aid in endometriosis treatment?
By Eylül GÜN
Current treatment modalities for endometriosis include a hormonal alteration which has many side effects and surgical removal which has a high postoperative recurrence rate. Alternative non-hormonal treatment methods have been investigated and anti-angiogenic therapy is one of them. Dr.s Chung…
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Is there a component of "microflora imbalance" in endometriosis?
By Nasuhi Engin Aydin
Dr. Oishi and colleagues from Ryukyus and Mie Universities, Japan, published a prospective cohort study on the microbiota of the female genital tract in the journal "Reproductive Medicine and Biology". Recent studies have found a small number of bacteria in…
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Early menarche increases the risk of endometriosis.
By Selma Oransay
Early menarche is the first menstrual bleeding occurring before 12 years of age. The timing of normal puberty in girls varies between nations due to genetic, socioeconomic, and environmental factors. Notably, the age of menarche decreased significantly in teenagers born…
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How does endometriosis affect the life course of the patients?
By Eylül GÜN
Endometriosis, as a chronic disease has impairing effects on women’s lives. Patients carry psychological, social, and work-related burdens along with debilitating physical symptoms. Studies have been performed on these issues at a particular time in patients’ lives, however, only a…
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The relation between body mass index and endometriosis
By Selma Oransay
The studies have emphasized a link between low BMI values and endometriosis, however, this conclusion may be questionable when the estrogen dependence of the disease is concerned. Excess adipose tissue may produce higher circulating estrogen that may result in an…
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Adenomyosis Increases Risk of Surgical Complications
By Özge Özkaya
Adenomyosis increases the risk of deep endometriosis surgery complications, according to a new study published in the journal Scientific Reports. Patients with deep endometriosis and adenomyosis should therefore be informed about this risk before undergoing surgery. Adenomyosis occurs together with…
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The consequence of COVID-19 pandemic on endometriosis patients
By Selma Oransay
The relevant policies and restrictions concerning Covid-19 have prevented patients from accessing medical care. Similarly, standard care for endometriosis patients has also been negatively impacted by postponed or canceled appointments and suspended surgeries across the countries. Women trying to cope…
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Preferential expression of some membrane type matrix metalloproteinase proteins
By Nasuhi Engin Aydin
Dr. Maoga and associates from academic institutions located in Germany and Kenya have published their findings on the immunohistochemical expression of MT-MMP proteins, namely MT2-MMP (MMP15) and MT3-MMP (MMP16) in the eutopic endometrium of healthy and endometriotic patients; and also…
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The evaluation of sexual dysfunction in infertile women
By Eylül GÜN
Infertility constitutes a serious health problem in women and men worldwide. The most common causes of women’s infertility are reported to be endometriosis and polycystic ovarian syndrome. The prevalence of infertility in women with endometriosis is as high as 50%.…
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Comparison of imaging techniques for estimating the depth of bowel wall infiltration by endometriosis.
By Selma Oransay
The surgical removal of deep endometriosis is the cornerstone of the management. However, the decision for the varying surgical approach types ranging from conservative management (shaving) to segmental or discoid resection depends on the depth of infiltration within the bowel wall, which…
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Self-Management Strategies for Endometriosis
By Özge Özkaya
Many self-management strategies for endometriosis are not more effective at reducing the symptoms of the disease compared to placebo or hormonal therapies, according to a new study published in the journal Reproductive Sciences. The authors, therefore concluded that “no recommendations…
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Social media and endometriosis management
By Selma Oransay
Endometriosis has a negative impact on social life, work, daily activities, personal relationship, and overall quality of life. A study from Australia recently published in the Australian New Zeland Journal of Obstetrics and Gynaecology reports that social media helps these…
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Atherosclerosis is augmented in laboratory mice by experimental endometriosis
By Nasuhi Engin Aydin
Dr. Taylor group from Yale School of Medicine, New Haven, CT, USA has published their experimental study in the "American Journal of Obstetrics & Gynecology" on atherosclerosis following endometriosis induction in laboratory mice. The basic inflammation process in endometriosis patients…
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No way to sleep when you suffer from pain
By Bahar Yuksel
Having chronic disease might alter the sleep quality and disturb sleeping periods. Besides insomnia, endometriosis itself changes the pain sensitivity and increases the body’s reaction to inflammatory and painful inputs. Thus, as a chronic and painful long-term situation, the relation…
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Geography May Influence Risk of Endometriosis
By Özge Özkaya
The risk of developing endometriosis seems to be geographically heterogeneous across France, according to results from a study published in the journal Scientific Reports. The study identified 20 high-risk hotspots around the country. These showed similar results for non-adenomyosis endometriosis…
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How possible is it to diagnose endometriosis from a urine sample?
By Eylül GÜN
The development of non-invasive diagnostic methods in endometriosis is essential for successful surveillance. Various biomarkers have been used for this purpose, including biomarkers from serum, peritoneal irrigation fluid, endometrial tissue biopsy, and urine. Dr. Chen et al. from Taiwan conducted…
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Abdominal wall endometriosis is not a rare disease as supposed
By Hale Goksever Celik
Abdominal wall endometriosis is an iatrogenic type of endometriosis defined as the localization of endometrial glandular and stromal tissue on the abdominal wall including skin, the rectus abdominis muscle, and rectus muscle sheath. Cyclical pain, mass located on the abdominal…
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The incidence of ovarian cancer after histologically diagnosed endometriosis.
By Selma Oransay
Ovarian cancer has the highest mortality rate among gynecologic cancers. Furthermore, these patients are generally diagnosed in advanced stage due to their non-symptomatic nature. Therefore, preventative strategies have enormous importance for the management of ovarian cancer. Dr. Hermens and colleagues…
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How reliable are the patient questionnaires in predicting endometriosis?
By Eylül GÜN
It is well known that the diagnosis of endometriosis is delayed in the majority of patients throughout the world. The burden that this brings has many effects on the patients’ lives as well as the society. The radiological developments in…
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Distribution of tubal endometriosis
By Selma Oransay
The incidence of tubal endometriosis was previously reported in a percentage of 4 to 11, but recent studies gave a prevalence up to 42.5 % which indicates the actual incidence of this disease is underestimated. Some studies in recent literature…
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A novel contribution to patient management in endometriosis by immunohistochemistry
By Nasuhi Engin Aydin
Dr. Tarumi and associates from the Kyoto Prefectural University of Medicine, Kyoto, Japan published their retrospective cohort study on the importance of progesterone receptors on recurring ovarian endometriosis in "The Journal of Clinical Endocrinology & Metabolism". Surgery for endometriosis is…
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Which of the suggested environmental risk factors are indeed related to endometriosis?
By Eylül GÜN
Endometriosis is a complex disease with genetic and environmental factors in its poorly understood pathogenesis. Even though many epidemiological studies in the literature have proposed several risk factors, the lack of clear establishment and modification of these potential risk factors…
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Listening to patients’ complaints is the first step on the way to a diagnosis of endometriosis.
By Hale Goksever Celik
Early diagnosis and management of endometriosis are not possible due to the wide spectrum of symptoms and absence of non-invasive diagnostic biomarkers. Particularly the adolescent population is at risk for the diagnostic delay because pelvic pain and dysmenorrhea are very…
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Are the studies based on the nationwide databases more accurate?
By Eylül GÜN
One of the most common localizations of endometriosis is the ovaries, and therefore, ovarian endometriomas are among the most surgically treated endometriotic lesions. Dr. Roman from Denmark has recently written an editorial about the surgical interventions on ovarian endometrioma and…
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Endometriosis diagnosis and management based on the best available evidence from published literature
By Selma Oransay
ESHRE, "European Society of Human Reproduction and Embryology" published a Guideline for the diagnosis and treatment of endometriosis in 2005 and then revised it in 2013. Based on new research and development there was a need to renew the last…
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Medicinal Cannabis Use for Endometriosis in Australia and New Zeland
By Özge Özkaya
Cannabis use leads to positive outcomes for the management of endometriosis according to the results of an online survey among patients from Australia and New Zealand. These findings, which were published in the journal Cannabis and Cannabinoid Research suggest that…
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Endometriosis information coming from the social media
By Bahar Yuksel
Today’s changing and evaluating world led everything to be lived online. For sure endometriosis and searching for cures or support for endometriosis have been transferred to online social media platforms too. The study conducted by Julian Matthias Metzler et al…
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What are the most common symptoms of endometriosis and how are they related to age?
By Eylül GÜN
Even though the incidence of endometriosis is relatively high and numerous studies are being conducted to elucidate its pathogenesis, it is still a highly underdiagnosed and undertreated disease. The symptoms of the disease are well-known; however, the correlation between the…
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A revolutionary view on endometriosis related pain
By Nasuhi Engin Aydin
Dr. Lydia Coxon and colleagues from Oxford University, UK, have recently published their cross-sectional study on the categorization of endometriosis-related pain in the journal "Frontiers in Pain Research". As a chronic inflammatory condition, endometriosis results in pelvic pain, dysmenorrhea, and…
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Prevalence of endometriosis and adenomyosis by transvaginal ultrasound.
By Selma Oransay
Women who present dyspareunia, dysmenorrhea, dysuria, dyschezia, chronic abdominal, and pelvic pain, and infertility would benefit from the early investigation. If the correct diagnosis of endometriosis and/or adenomyosis can be made in advance, early treatment will improve the quality of…
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Mindfullness Can Hep Reduce Endometriosis Pain
By Özge Özkaya
A brief mindfulness-based intervention can be useful in managing pain related to endometriosis and restoring patients’ psychological well-being, found a new study published in the European Journal of Pain. This finding contributes to the applicability of mindfulness-based interventions in people…
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Planning surgery for recto-sigmoid endometriosis with 3D virtual models.
By Selma Oransay
Efforts to reduce the high complication rate of rectosigmoid surgery in deeply infiltrated endometriosis are of great interest to gynecologists. 3D printing, currently used in various surgical specialties to support surgical planning and guide intraoperative procedures may be a way…
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Non-invasive diagnostic tools for endometriosis revisited
By Nasuhi Engin Aydin
Dr. Signorile and associates from the Italian Endometriosis Foundation have published the results of their retrospective study on a large cohort of endometriosis patients in a recent issue of the periodical, In Vivo. Endometriosis lacks precise scientific knowledge and this brings…
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The underlying reason of implantation failure in women with endometriosis-associated infertility
By Hale Goksever Celik
Endometriosis is most frequently encountered in reproductive-aged women, with a prevalence of 10-15% in the general population. However, endometriosis is more frequently diagnosed in infertile women, with a prevalence of 25-40%. Although the exact mechanism explaining the association between endometriosis…
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Cannabis use in the management of endometriosis-related pain during the COVID19 pandemic
By Eylül GÜN
Pain management in endometriosis has been challenging owing to many reasons. Since the pathways that cause pain in endometriosis have not been elucidated extensively, the medical and surgical management of pain remains to be symptomatic. Alternative pain management methods have…
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Prolactin receptor antibodies: A novel treatment proposal for endometriosis
By Eylül GÜN
Prolactin, a hormone that also acts as a proinflammatory cytokine through its receptor PRLR has been shown to be involved in endometriosis pathogenesis. Previous studies reported that women suffering from endometriosis had elevated prolactin levels. Also, in experimental studies done…
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A French National Study Concerning The "Recovery Protocol" After Deep Infiltrating Endometriosis Surgery.
By Selma Oransay
In recent years especially for complex surgeries, enhanced recovery after surgery (ERAS) programs have been implemented in several surgical specialties. This is based on a multimodal and multidisciplinary approach centered on the patient’s perioperative situation designed to improve patient management and reduce…
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International Working Group's review on endometriosis classification systems
By Nasuhi Engin Aydin
International Endometriosis Working Group including AAGL, ESHRE, ESGE, and WES published a comprehensive review on endometriosis classification, staging, and reporting systems in a recent issue of the journal named "Facts, Views & Vision in Obstetrics and Gynecology". Classification and staging…
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Imaging Techniques Able to Predict Depth of Endometriosis Before Surgery
By Özge Özkaya
Transvaginal ultrasound (TVUS) and pelvic magnetic resonance imaging (MRI) performed by a specialist can accurately predict the depth of rectosigmoid endometriosis before surgery, according to a new study published in the Journal of Minimally Invasive Gynecology. Both approaches are similar…
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A novel scoring tool to standardize surgical complexity for gynecologists.
By Selma Oransay
The field of gynecologic surgery needs a more comprehensive, objective, and reproducible method for assessing and communicating surgical complexity than the current approach. Actually, there is no formal image-based system that allows surgeons to categorize and communicate the complexity of…
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An important enigmatic promoter of endometriosis: immune dendritic cells
By Nasuhi Engin Aydin
Dr. Larinha and associates from a Brasilian academic center have published their comprehensive review on the role of immune dendritic cells in the pathogenesis of endometriosis in a recent issue of the "Journal of Reproductive Immunology". Antigen-presenting dendritic cells of…
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A quick insight into the latest research on endometriosis diagnosis and management
By Eylül GÜN
Endometriosis research has been expanding with many new studies ranging from new techniques and markers in diagnosis to updates in clinical management and treatment of the disease. The journal Frontiers in Surgery recently brought together articles that reflect important and…
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Immunotherapy in endometriosis: a challenging research topic
By Nasuhi Engin Aydin
Dr. Maksym and associates from academic centers in Poland have published their comprehensive review on endometriosis emphasizing the immunological aspects of the disease in a recent issue of the "Journal of Clinical Medicine". Even though endometriosis is a multifactorial disease,…
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Algorithm for pain management in endometriosis
By Selma Oransay
One of the debilitating symptoms of endometriosis is pain. Mostly due to delayed diagnosis and the high recurrence rate, even after the surgical and hormonal therapy pain control may not be sufficient causing the patient to suffer for decades. Endometriosis-associated…
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A New Non-Invasive Marker for Endometriosis?
By Özge Özkaya
The reactivity of serum immunoglobulin G (IgG) with fucose-specific lectins AAL, LCA, and LTA could be a useful diagnostic biomarker for endometriosis, according to a new study published in the Journal of Inflammation Research. It could also be a clinical…
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Is "non-hormonal therapy" effective in women with endometriosis-associated pain?
By Hale Goksever Celik
Women with endometriosis require effective treatment due to the negative impact of the disease on quality of life. Hormonal treatments including oral contraceptives, and progestins are usually recommended to suppress ovulation and decrease pelvic pain. However, some women do not…
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Risk of cardiovascular disease in endometriosis patients
By Eylül GÜN
A well-known fact about endometriosis is the inflammatory processes that underlie its pathophysiology. The inflammatory markers have been thought to play a role in many additional disorders in endometriosis patients. One of the primary markers of inflammation is C-reactive protein…
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The consequences of endometriosis on the quality of life
By Hale Goksever Celik
The most common clinical findings of endometriosis patients are pelvic pain and fertility problems, resulting in impairment of quality of life. These women are affected especially during the menstruation period. Olliges et al., from Germany and Switzerland, published a study…
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Surgery for the Treatment of Endometriosis of the Diaphragm and Thorax
By Özge Özkaya
Diaphragmatic and thoracic endometriosis starts in the abdominal wall of the diaphragm and later invades the thorax, based on findings from a series of patients surgically treated for the disease, reports a study published in the Journal of Gynecology Obstetrics…
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Diaphragmatic defects, liver herniations and catamenial pneumothorax
By Nasuhi Engin Aydin
Dr. Arakawa and associates from The Jikei Katsushika Medical Center, Japan, have published their recent case of catamenial pneumothorax with diaphragmatic defect and liver herniation in the "Journal of Cardiothoracic Surgery". Catamenial pneumothorax is an uncommon condition with a reported…
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Endometriosis of the Diaphragm, What do the Doctors Know About it?
By Özge Özkaya
The median time between the first consultation with a primary care physician and receiving a diagnosis of endometriosis of the diaphragm is two years according to a study by U.K. researchers. In the worse case, it took 23 years for…
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The largest series of diaphragmatic endometriosis
By Bahar Yuksel
Diaphragmatic endometriosis is one of the most common extra pelvic endometriosis types, yet the correct incidence is unclear. In the study conducted by Ceccaroni Marcello et al from the International School of Surgical Anatomy, Verona, Italy, the authors analyzed the…
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Diaphragmatic endometriosis
By Selma Oransay
Diaphragmatic endometriosis is a rare clinical condition that may show signs and symptoms like chest pain, right upper quadrant abdominal pain, shoulder pain, pleuritic pain, hemothorax, pneumothorax, hemoptysis, and thoracic endometriosis syndrome while the major part of the patients is…
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Thoracic endometriosis: the most frequent endometriosis involvement outside abdominopelvic cavity
By Nasuhi Engin Aydin
Six to ten percent of reproductive-age women are affected by endometriosis, and about 12% are estimated to be outside the abdominopelvic cavity - the most frequent location being the thorax. Endometriosis within the pulmonary parenchyma or on the diaphragm and…
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Urinary Tract Endometriosis
By Bahar Yuksel
Endometriosis is mostly seen in patients of fertile age, and urinary tract endometriosis affects 1.2 to 6% of women with endometriosis. French coloRectal Infiltrating ENDometriosis Study (FRIENDS) group investigated the characteristics of urinary tract endometriosis in 232 patients from 31 centers. Authors…
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Which surgical technique is best for rectal endometriosis?
By Eylül GÜN
One of the common sites for deep endometriosis is the intestines, with a rate of 3-37%. Intestinal endometriosis constitutes a serious cause of gastrointestinal symptoms, pain, and the alteration of the quality of life, with the rectum and sigmoid colon being…
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Nerve-sparing technique for deep infiltrating endometriosis and its impacts on pelvic organ and sexual functions.
By Selma Oransay
Deep infiltrating endometriosis and involvement of parametrium cause severe pelvic pain and dysfunction of some pelvic organs resulting in a reduction in women's quality of life. Although surgery for DIE aims to relieve pelvic pain, entering into the posterior parametrial…
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Effects of Bowel Endometriosis Surgery on Mode of Delivery
By Özge Özkaya
Less than a third of doctors counsel women about the possible effects of surgical treatment of bowel endometriosis on their mode of delivery should they become pregnant, according to a new study published in the Journal of Obstetrics and Gynaecology.…
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A comparison of endometriosis Classifications: rASRM, EFI or Enzian?
By Selma Oransay
None of the endometriosis classifications provide a clinically valuable system since the very first description of the disease in 1860. One unique terminology to describe the localization and the extension of the disease is needed, which should be the same…
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Egg or chicken, which is causing bladder symptoms, DIE or surgery for DIE?
By Bahar Yuksel
Urinary symptoms could be overwhelming and sometimes could be hidden behind pain symptoms, but still might cause secondary damages on kidneys and bladder if remain undetected. In the prospective study conducted by Laterza et al, the authors questioned whether the…
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Surgery before in-vitro fertilization – Is it beneficial in patients with deep endometriosis?
By Eylül GÜN
Deep pelvic endometriosis is thought to be related to infertility by altering the pelvic environment and anatomy due to pelvic adhesions, and the changes in endometrial receptivity contribute to it. The discussion on whether the surgical intervention was beneficial started…
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Quality of life assessment in women with endometrioma
By Eylül GÜN
Like most chronic diseases, endometriosis poses a significant risk of diminishing the quality of life in patients suffering from it, particularly with its most considerable symptom; chronic pelvic pain. Although it is known that endometriosis is more common in East…
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Evaluation of daily diary for endometriosis-related pain.
By Selma Oransay
Some endometriosis patient-reported outcomes elements have been previously developed in accordance with regulatory and best practice guidelines including Endometriosis Pain Daily Diary, the Endometriosis Symptom Diary, and Endometriosis Impact Scale. The aim of this study was to develop another content-valid…
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Endometriosis: Beyond the naked eye visibility
By Bahar Yuksel
The gold standard method for endometriosis diagnosis is histopathologic evaluation of the resected lesions. The study conducted by Sara-Michelle Gratton et al. in Canada evaluated the possible effect of developed laparoscopic skills and equipment on the endometriosis diagnosis, and whether…
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Full understanding the role of nervous system in endometriosis could yield new gateways to novel therapeutic approaches
By Nasuhi Engin Aydin
Dr. Velho and associates from Berlin, Germany have recently published their comprehensive review on the role of the nervous system in endometriosis in a recent issue of “International Journal of Molecular Sciences”. Understanding the role of the peripheral nervous system…
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Endometriosis Seems to Affect The Development of the Embryo
By Özge Özkaya
Embryos development is impaired in embryos from women with endometriosis found a new study published in the Journal of Assisted Reproduction and Genetics. In spite of this, the outcomes of in vitro fertilization (IVF) are similar for patients with endometriosis…
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Is intrauterine insemination effective in women having endometriosis-associated infertility?
By Hale Goksever Celik
The most common presenting complaints of women with endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Affected women demand therapy for these symptoms of endometriosis, notably fertility problems. Several underlying mechanisms have been proposed to explain endometriosis-associated infertility including anatomic…
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The necessity of laparoscopy for unexplained infertility.
By Selma Oransay
The standard for accepting a couple as "infertile" is the inability to conceive after 12 months of regular unprotected intercourse. When this condition is met, assessing the number of motile sperm in the male partner and certifying the patency at…
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The Role of Endometrial Cytokines on the Infertility in Endometriosis Patients
By Eylül GÜN
The intrauterine microenvironment and underlying immunological mechanisms in endometriosis pathogenesis have been a popular research topic, mainly due to the efforts to comprehend the reason to elucidate infertility that these patients suffer from. Because of their superiority to other immune…
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Association of psoriasis and endometriosis
By Selma Oransay
Psoriasis is an immune-mediated inflammatory skin disease characterized by scalpy, red, and well-demarcated skin plaques that are observed in 2-4% of the population. Approximately 30% of psoriatic patients additionally have joint pain, stiffness, and swelling called psoriatic arthritis. The mechanism…
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How likely is it to get pregnant and have a baby after undergoing surgery for high stage endometriosis?
By Eylül GÜN
As one of the most common causes of infertility in women, endometriosis might be surgically interfered with depending on the stage. For Stage I and II endometriosis, surgery is recommended in the latest guidelines to ameliorate fertility rates, however, there…
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Physical activity and exercise in reducing endometriosis symptoms
By Eylül GÜN
The treatment modalities to date on endometriosis have focused on the symptomatic relief and management of chronic pain. Hormonal suppression sometimes shows intolerable side effects and is known to lose effect after some time. Surgical interventions may not provide a…
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Is it iron that calls vessels to form endometriosis
By Bahar Yuksel
The trigger mechanism of endometriosis formation is still under investigation. But it is clear that there is an iron overload on endometriotic lesions. In the study conducted by Guojing Li et al, the mechanism of iron on endometriosis formation has been…
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Pain alone is not a specific predictor for endometriosis diagnosis
By Hale Goksever Celik
The most common symptoms and signs of women with endometriosis include dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. However, diagnostic delay still occurs due to the broad clinical spectrum of the disease and the absence of non-invasive diagnostic biomarkers. Gordon et…
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The quality of life and mental health in endometriosis patients
By Eylül GÜN
One of the most important aspects of having a chronic illness comes with its relative effect on the patients’ quality of life and mental health status. Being among the most debilitating diseases in women in the reproductive period, endometriosis is…
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How Likely Am I to Conceive After Endometriosis Surgery?
By Özge Özkaya
Women with superficial peritoneal endometriosis and just one type of lesion are more likely to conceive after surgery, according to a new study published in the International Journal of Gynecology and Obstetrics. This is important because patients will be better…
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From Spain: execution for endometriosis and chronic pelvic pain unresponsive to conventional therapies
By Selma Oransay
The current conventional therapy for chronic pelvic pain for endometriosis is defined as either hormonal or non-hormonal medical treatment starting with combined oral contraceptives progestins or dienogest, and then gonadotropin-releasing hormone analogs and/or surgery. Although conventional therapies usually are successful, still…
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The relevance of mitosis in endometriotic tissue biopsies
By Nasuhi Engin Aydin
Dr. Wetzk and co-workers from the Technical University, Dresden, Germany have published a retrospective study on the diagnostic impact of mitotic activity in the endometriotic lesion biopsies in the recent issue of the journal “Geburtshilfe und Frauenheilkunde”. Guidelines highly recommend a…
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The higher the Endometriosis Fertility Index, the higher the chance of getting pregnant
By Hale Goksever Celik
The women who desire to get pregnant may also suffer from fertility problems depending on several mechanisms such as anatomic distortion, peritoneal adhesions, tubal dysfunction, impaired quality of oocytes, and impaired endometrial receptivity. One of the most important problems in…
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Importance of Language in Communicating Endometriosis Pain
By Özge Özkaya
Language is of great importance for women with endometriosis to communicate their pain to their doctor, according to a new study published in Frontiers in Global Women's Health. The study also found that additional tools are needed to help women…
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What do endometriosis and ovarian cancer have in common?
By Bahar Yuksel
While endometriosis is not a malignant disease, it is for sure known that it shares genetic disorders with cancers. In the bioinformatics study applied by Leyi Ni et al, the researchers analyzed the genetic pathways shared by both ovarian cancers…
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A novel target proposal in endometriosis: Phoenixin
By Eylül GÜN
As well as being a hormone-dependent reproductive system disorder, endometriosis is known to be multifactorial, which makes its etiopathogenetic mechanisms even harder to understand. Many new targets have been vastly evaluated with the hope of finding a new diagnostic test…
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A study design to improve the patient-centeredness in endometriosis care.
By Selma Oransay
It is well known that endometriosis causes impaired daily activity and productivity along with energy loss, fatigue, pelvic pain, deep dyspareunia, and further, infertility accompanies all these negative influences. The chronic nature of the disease forces clinicians to plan long-term care…
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Emotions on the 'Surgery Requirement' in patients with bowel endometriosis
By Eylül GÜN
Endometriosis is known to have many adverse effects in patients’ lives such as a significant decrease in the quality of life, psychosocial problems, loss of productivity and focus while working. With the constant chronic pain, the patients mostly present with…
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An Overview on Treatment of endometriosis
By Selma Oransay
There are different guidelines by different gynecological societies for the diagnosis and treatment of endometriosis, which is an extremely complex illness. Kalaitzopoulos and Samartzis et al. from Switzerland worked on and compared six national and two international widely used guidelines to…
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A trial of exogenous melatonin on dysmenorrhea in women "without endometriosis"
By Nasuhi Engin Aydin
In their recent article published in “European Journal of Clinical Pharmacology”, Dr. Söderman and associates from Stockholm report the results of their randomized, double-blind, placebo-controlled trial on the effects of oral melatonin in women with dysmenorrhea -unrelated to endometriosis-. Melatonin is a hormone…
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New Endometriosis Clinical Trial Now Recruiting Participants
By Özge Özkaya
A new clinical trial investigating the effect of cognitive-behavioral therapy on quality of life in patients undergoing surgery for endometriosis is now recruiting participants. The randomized, controlled trial aims to recruit 100 participants, ages 18 to 50 with proven endometriosis…
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Which one is more effective for the preservartion of postoperative ovarian reserve?
By Selma Oransay
Although cystectomy is the most preferred treatment of endometrioma, it is still a matter of debate as it may cause a reduction in the quality and number of remaining follicles, especially important for women who are planning to conceive. Anti-Müllerian…
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Placenta praevia and cesarean section more common in patients with ART for Endometriosis
By Hale Goksever Celik
Even though endometriosis is known to be associated with infertility, these women still have a chance to get pregnant spontaneously or by assisted reproduction techniques (ART) with the aid of recent technological developments. A It has also been shown that…
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Matrix metalloproteinases and their role in endometriosis
By Eylül GÜN
The extracellular matrix harbors important macromolecules such as collagen and glycoproteins which are required for tissue remodeling, differentiation, and homeostasis. The main group of enzymes responsible for these properties is called matrix metalloproteinases (MMPs). It has been proven that MMPs…
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Indocyanin Green dye for recognition of occult endometriotic lesions
By Bahar Yuksel
The surgery for endometriosis is challenging and the resection of all lesions is not accurately related to not catching all lesions under white light (WL) conventional laparoscopy. In the study conducted by Luigi Carlo Turco et al., in a tertiary…
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Evaluation of patient self-reported outcome measures for endometriosis.
By Selma Oransay
Endometriosis symptomology is multifactorial and it changes over time based on the patient's life experience, perceptions, and medical treatment. These changes require the agility of adaptation for both clinicians and patients to respond properly. The documentation of the patient's specific…
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Efficacy of cannabis on endometriosis symptoms
By Eylül GÜN
Endometriosis is related to a wide range of symptoms that affect the quality of life of patients in many aspects. Studies have shown malfunctions in the endocannabinoid system in endometriosis patients which led to the idea to target this pathway…
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Endometriosis and women’s social lives, work and education.
By Hale Goksever Celik
The women with endometriosis present with a broad clinical spectrum including pelvic pain, dysmenorrhea, dyspareunia, and infertility. All of these symptoms and signs may have a negative impact on women’s lives by having endometriosis. Mastrangelo and Turnbull, from Australia, published…
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Herbicide Alters Immune System on the Route to Endometriosis
By Bahar Yuksel
A popular environmental pollutant and herbicide named 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) and its receptor named aryl hydrocarbon receptor (AHR) have been suggested for causing endometriosis, but the mechanism was not clear. In the study conducted by Mahsa Tanha et…
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Intravascular adenomyomatosis: an important entity to be alert
By Nasuhi Engin Aydin
Pathologists from Stanford University, USA have recently published four novel cases of intravascular adenomyomatosis co-existing with pelvic endometriosis in a recent issue of “Human Pathology”. Intravascular leiomyomatosis is characterized by the presence of smooth muscle in venous and lymphatic spaces…
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A novel in-vitro endometriosis model with KRAS and PIK3CA mutations
By Eylül GÜN
A plethora of research has been ongoing to illuminate the pathogenesis of endometriosis which is a multifactorial disease. These studies have proven the association between some mutated cancer driver genes and endometriosis, and links between certain cancers such as ovarian…
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Is breastfeeding beneficial to endometriosis pain?
By Nasuhi Engin Aydin
Dr. Porta team from Italian academic centers have recently published their research in “International Journal of Environmental Research and Public Health” on breastfeeding mothers who were under follow-up for histologically proven endometriosis. The hormonal milieu is believed to have an important…
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International definition and standardization for endometriosis
By Selma Oransay
There is huge heterogeneity in classifications, subtypes, diagnostic and therapeutic interventions of endometriosis in published literature. The lack of a uniform and widely accepted terminology of the disease rose the necessity to argue and reach a common consensus with organizations,…
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Preoperative Neutrophil-to-Lymphocyte Ratio for prediction of postoperative pregnancy
By Hale Goksever Celik
Among women with endometriosis, 30 to 50 percent are estimated to have infertility, and 25-50% of infertile patients are found to have endometriosis. Anatomic distortion, diminished tubal peristalsis, diminished sperm movements, dysfunctional folliculogenesis, luteal phase dysfunctions, and alterations in endometrial…
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Relationship Goals and Sexual Satisfaction for Couples Coping with Endometriosis
By Selma Oransay
"Relationship satisfaction" is based on an individual's emotional judgment. Physical and emotional obstacles may present and negatively affect relationship satisfaction. Endometriosis is associated with multiple life domains, and also includes relationship and sexual satisfaction. Sexual satisfaction, on the other hand,…
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Cross-cultural translation and adaptation of an endometriosis survey
By Eylül GÜN
Endometriosis is a disease that presents heterogeneously which makes it hard to identify a causal relationship. A patient-based questionnaire called Endometriosis Participant Questionnaire (EPQ) has been originated by The World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project. It…
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A plea from pathologists: standardized protocols for adenomyosis and endometriosis
By Nasuhi Engin Aydin
Pathologist Drs. Camboni and Marbaix from Brussels, Belgium published their comprehensive review on adenomyosis and endometriosis titled “Ectopic endometrium: the pathologists’ perspective” in a recent issue of the International Journal of Molecular Sciences. Endometriosis and adenomyosis are well-known entities as…
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The effect of hormone therapy after surgical menopause on endometriosis recurrence
By Selma Oransay
Definitive surgery for severe and advanced endometriosis is hysterectomy with bilateral oophorectomy, which may cause vasomotor symptoms, sleep deprivation, mood change, and dyspareunia in the patients. Furthermore, after the surgical removal of the ovaries, the sudden drop in estrogens causes…
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Does Surgery Improve the Digestive Symptoms of Endometriosis?
By Özge Özkaya
Women with deep infiltrating endometriosis involving the bowels have the most significant improvement in gastrointestinal symptoms following surgery. This is according to the findings of a comparative retrospective study in almost 1,500 women. “Women with severe bowel symptoms and deep…
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Pharmacological Therapy for Endometriosis Pain
By Eylül GÜN
The negative effects of endometriosis on women’s quality of life are indisputable. Women who suffer from endometriosis might have to deal with problems in many aspects such as psychological, sexual, social, and economic. Pain which is one of the most…
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Environmental factors play a role in the development of endometriosis
By Hale Goksever Celik
The proposed mechanisms underlying the development of endometriosis may be classified into three groups: in-situ theory, implantation theories, and induction theories. Genetic, hormonal, environmental, and lifestyle-related factors are also involved as no mechanism is solely responsible for endometriosis development. Although there are…
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The new Endometriosis Surgical Complexity Classification: AAGL 2021
By Selma Oransay
Multiple endometriosis categorizations have been approved in the recent forty years. The American Fertility Society proposed ASRM with a desire to score the impact of the endometriosis in 1996, which was updated several times later (rASRM), to predict infertility after laparoscopic operations. For…
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Dietary adjustments do not increase the quality of life of women with endometriosis.
By Özge Özkaya
Even though dietary changes do not seem to increase patients’ quality of life, they lead to a perceived reduction in symptoms. No specific adjustment in the diet increases the quality of life of women with endometriosis, according to a new…
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Inflammatory and genetical background of endometriosis may yield new therapeutic approaches
By Nasuhi Engin Aydin
Elisa Giacomini and colleagues from medical centers in Milan, Italy have published their review manuscript on the inflammatory and genetical pathogenetic background of endometriosis in a recent issue of “International Journal of Molecular Sciences”, suggesting also new therapeutic approaches. The inflammatory…
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It is "pain" that causes sleep disturbances and fatigue in endometriosis patients
By Bahar Yuksel
Endometriosis has been studied previously about its effects on quality of life and the possible effects on sleeping periods. The study conducted by Federica Facchin et al. questioned the reason for endometriosis to cause sleep disturbance. The authors have divided…
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How does adenomyosis affect IVF outcomes?
By Hale Goksever Celik
Adenomyosis is defined as the localization of endometrial tissue in the muscle layer of uterus. Several theories have been proposed to explain the reasons of adenomyosis-associated infertility including uterine dysperistalsis, abnormal transportation of sperm in the uterine cavity, and embryo…
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Green tea as a therapeutic agent in endometriosis
By Eylül GÜN
Tea is among the most consumed beverages all around the world. It has many kinds which originate from the same plant “Camellia sinensis” but differ in color after the fermentation process. Green tea is the one produced right after the…
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Molecular alterations in endometriosis pathogenesis
By Eylül GÜN
Endometriosis has been in our lives for decades, however little is known about its pathogenesis making it hard to diagnose and manage. A review study conducted by Balasubramanian et al. from India reveals all the characteristics and the underlying conditions…
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Phytoestrogens could have promising effects in endometriosis management
By Nasuhi Engin Aydin
Dr. Bartiromo and associates from Milan, Italy published a systematic review on phytoestrogens and endometriosis in the periodical “Nutrients”. Endometriosis has features of chronic inflammation based on uncontrolled hormonal response and immune-mediated dysfunctions. Estrogens are endocrine and paracrine agents that could yield…
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Complex Relation Between Body mass index and endometriosis
By Selma Oransay
This research aimed to find the relationship between BMI and endometriosis especially related to surgical phenotype and lesion location. An observational cohort study was led by Holdsworth-Carson et al, from Australia. The article was recently published in "RBMO" . Many earlier studies report…
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Urinary Function Alterations after Surgery for Deep Endometriosis.
By Selma Oransay
Laparoscopic surgery is a mainstay therapy for symptomatic patients with DE. Although our findings of improvement in many domains of urinary function are encouraging, postoperative deterioration in urinary function was found for patients with initial normal function. More research is…
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Resveratrol for endometriosis
By Bahar Yuksel
Endometriosis has been studied previously about its inflammatory nature and its tendency for causing macrophage disfunction. In the study conducted by Chunyan Wang et al, the researchers analyzed the effect of a flavonoid, "resveratrol" on endometriosis lesions and the mechanism…
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The comparison of the effect of hemostatic techniques on ovarian reserve during endometrioma cystectomy
By Hale Goksever Celik
The possible negative effect of the surgical excision of endometriomas on the ovarian reserve has brought up the meticulous implementation of the decision for surgical approach. Dr. Raquel Silveria da Cunha Araujo et al, from Brazil, published a study titled as…
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Endometriosis, pelvic inflammatory disease and ovarian cancer
By Eylül GÜN
Endometriosis is a locally aggressive and chronic inflammatory disease and it is now known that with various genetic pathways it creates susceptibility to certain cancers, the most common being ovarian cancer. Pelvic inflammatory disease on the other hand creates a…
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Persistence of Chronic Pelvic Pain after Hysterectomy
By Hale Goksever Celik
Chronic pelvic pain is defined as the "pain in the pelvic area that lasts for 6 months or longer". There are several gynecological, urological, and gastrointestinal reasons for the development of chronic pelvic pain. Nociceptive pain or central sensitization is…
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Assisted Reproductive Technology Outcomes in Women with and without Endometriosis
By Selma Oransay
Endometriosis causes infertility in one-third of patients, while in approximately 25-35% of infertile women, the cause is endometriosis. The primary interest and the question of Moss et al. from the University of Queensland, Brisbane, Australia was "the differences in the…
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Etiopathogenesis of Endometriosis and Links with Endometrial Cancer
By Nasuhi Engin Aydin
Professor Terzic and colleagues from the Medical School of Nazarbayev University, Kazakhstan published their review on the molecular aspects of endometriosis and endometrial cancer in “International Journal of Molecular Sciences”. The etiopathogenesis of endometriosis has remained controversial, with recent studies…
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How to Reduce Pain After Laparoscopic Surgery
By Özge Özkaya
Using humidified warm gas with forced-air warming blanket during laparoscopic surgery resulted in significantly less pain in the recovery room, according to a new study published in the journal "Surgical Endoscopy". In patients with endometriosis, using humidified warm air even…
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Routine preoperative ureteral stent and complications in Deep Infiltrating Endometriosis
By Bahar Yuksel
Deep infiltrative endometriosis is a devastating disease that includes both anterior and posterior compartments, and ureteral infiltration with endometriotic nodules affects 1 to 6% of all deep infiltrative endometriosis patients. In the study conducted by Giulia Borghese et al., the…
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Lead and cadmium exposures of female workers should be reduced as much as possible
By Nasuhi Engin Aydin
Min-Gi Kim and associates from Korea published their results on the possible effects of lead and cadmium exposure in endometriosis induction and severity in a recent issue of “International Journal of Environmental Research and Public Health”. Endometriosis is an illness…
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Impact of surgery before IVF in infertile women with endometrioma
By Hale Goksever Celik
Among the women with endometriosis, 30 to 50% are estimated to have infertility. On the contrary, among women who present with infertility, 25 to 50% are estimated to also have endometriosis. Several mechanisms have been proposed to explain the association…
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Small chain fatty acids produced by gut microbiota: Could that be the missing milestone for endometriosis
By Bahar Yuksel
Endometriosis is a worldwide problem but still, the underlying mechanism and optimal treatment options are controversial. In the study conducted by Sangappa B Chadchan et al., the researchers investigated the possible relationship between gut microbiota and endometriosis. A study published…
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Ovarian cancer risk in endometriosis and adenomyosis
By Eylül GÜN
Through the historical development of the nomenclature for endometriotic tissue found inside and/or outside the uterus, many terminologies have been used. The accepted terminology is still the one introduced by Sampson: “Endometriosis”. “Adenomyosis” also known as “endometriosis interna” which is…
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Uterine cancer risk in "endometriosis" and "adenomyosis"
By Selma Oransay
Adenomyosis and endometriosis share similar characteristics, and endometriosis is reported to have an increased risk of ovarian cancer. However, the risk of uterine cancer is not clear yet. Hermens and colleagues from Catharina Hospital, from the Netherlands, designed a population-based…
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Endogenous cannabinoids are related to endometriosis pain
By Eylül GÜN
Pain, specifically dysmenorrhea is the most important symptom of endometriosis. Prostaglandins are the main director of the pain process in dysmenorrhea, therefore the mechanisms affecting the prostaglandin metabolism have been studied in order to find a treatment for pain, and found that…
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Dienogest treatment increases the risk of Endometriosis reoperation rate
By Selma Oransay
The common and accepted therapy of endometriosis is surgery, however medical treatment such as nonsteroidal anti-inflammatory drugs, gonadotropin-releasing hormone agonists, oral contraceptives and oral progestins are used for either relieving pain or to prevent recurrences and reoperation. Due to bone loss and…
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Body Mass Index and indicators of metabolic syndrome in women with Endometriosis
By Hale Goksever Celik
Endometriosis is a disease of reproductive-aged women and has common pathophysiological mechanisms with other chronic health morbidities due to its estrogen-dependent chronic inflammatory background. The changes in the inflammatory components of adipose tissue may have an impact on the quality of…
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Potential new Target to Reduce Endometriosis Pain
By Özge Özkaya
The inflammatory mediators, bradykinin, and bradykinin B1 receptor may play a role in the onset of endometriosis-associated pain according to a new study by Chinese researchers. They do so by inducing the prostaglandin signaling pathway. Therefore, targeting these biological pathways…
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Best practice: How to reduce intraoperative bleeding?
By Selma Oransay
Although laparoscopic hysterectomy is a popular and common approach for removing benign uterine lesions, some technical steps especially concerning uterine artery closure depend on the surgeon's preference. Uterine artery ligation may be performed either at the uterus level, which is common…
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A new "survey-based" endometriosis diagnostic tool
By Bahar Yuksel
Endometriosis is a disease that is diagnosed years after its appearance which causes life quality impairment to patients. It is crucial for the patient to find out the probability of the presence of endometriosis, for applying to healthcare providers before…
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Altered Decidualization and Pregnancy Complications
By Nasuhi Engin Aydin
Dr. Carlo Ticconi and colleagues from Italy published their comprehensive review manuscript “Clinical consequences of defective decidualization” in the June 2021 issue of “Tissue and Cell”. Currently, there has been growing research interest in the study of decidualization, and knowledge of…
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Catching endometriosis from the front line: educating general practitioners
By Bahar Yuksel
It should be repetitively pronounced that "endometriosis is very common and it is very important to diagnose it as soon as possible before it causes lifelong damage to women’s lives". The sooner the better concerning the diagnosis, and this is…
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A rare complication of endometriosis
By Selma Oransay
Morales et al. from the Monterrey School of Medicine, Mexico, reported a case of bowel intussusception in a woman with severe endometriosis to draw attention to this very rare endometriosis complication. The case is a 27 years old young female…
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Not all endometriotic lesions behave similar to the eutopic endometrium
By Eylül GÜN
The most widely accepted theory of endometriosis pathophysiology is Sampson’s theory of retrograde menstruation which suggests the ectopic lesions undergo the same hormonal and morphological changes as eutopic endometrium during the menstrual cycle. Recent studies have shown that only a…
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Research Identifies New Genes That Could Be Targeted to Treat Endometriosis
By Özge Özkaya
Researchers identified three new genes that could help understand the invasiveness of endometriosis. They also identified one new gene that could be related to the recurrence of the disease. These genes may potentially be new therapeutic targets for endometriosis. In…
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By Dr. Youngran ParkAwareness is the first step toward endometriosis treatment
By Dr. Youngran Park
We want to reiterate the importance of endometriosis, by handling the paper entitled "Endometriosis awareness: screaming at the top of our voices" published on April 2021 in the journal “Women & Health”. The Endometriosis Awareness Month of 2021 was a little different,…
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A new "nonhormonal" treatment target in endometriosis
By Eylül GÜN
Endometriosis is a chronic inflammatory condition that affects millions of women globally. With pelvic pain being its most common symptom, the cost of the treatment of disease-associated symptoms has been found to be almost as high as type 2 diabetes.…
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The incidence of endometriosis may vary over time according to age, period and cohort
By Hale Goksever Celik
Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. Early diagnosis has importance as endometriosis impairs the quality of life of patients and creates a serious social and economic burden. Fortunately, earlier diagnosis and management of endometriosis becomes…
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A new assessment tool for the multi-dimensional burden of endometriosis
By Eylül GÜN
Endometriosis is a disease that has multiple effects on patients’ lives in various ways. The quality of life, the status of the patient’s relationships, the continuity and productivity in the patient’s education and work environment, and psychological, emotional, and even…
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Ovarian Cancer Survival in the presence of Endometriosis
By Özge Özkaya
Women with ovarian cancer and histologically proven endometriosis have longer overall survival compared to those with ovarian cancer but no endometriosis, found a study published in the American Journal of Obstetrics & Gynecology. “[…] Women diagnosed as having ovarian cancer…
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The added value of transvaginal hydro-laparoscopy for infertile women
By Selma Oransay
The added value of invasive diagnostic laparoscopy has been questioned, postponed by the increased usage of ultrasonography for the evaluation of infertile patients. Gordts et al. from Life Expert Center, Leuven, Belgium have been working on an alternative way called "transvaginal hydro-laparoscopy" to…
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The role of physical examination and interview in Endometriosis Diagnosis
By Bahar Yuksel
Today we know that the most accurate diagnosis of endometriosis necessitates surgery and histopathological examination of the excised lesions. However, many women are misdiagnosed due to various symptoms of endometriosis which mystify gastrointestinal, urinary, and musculoskeletal diseases. Nawrocka-Rutkowska and colleagues…
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The incidence and prevalence of endometriosis in a United States population-based study .
By Selma Oransay
To define the accurate incidence and prevalence estimates of endometriosis among nonselected cohorts in the USA, Christ et al. from the Departments of Obstetrics and Gynecology of the University of Washington, Seattle, planned a retrospective cohort study using the electronic KPWA…
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Long noncoding RNAs to predict the endometriosis recurrence
By Hale Goksever Celik
Despite extensive research, the exact pathophysiologic mechanism of endometriosis remains unclear; and the absence of non-invasive biomarkers to diagnose endometriosis is still a big problem both for clinicians and patients. The recurrence of endometriosis is another challenge that is difficult…
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Endometriosis & adolescents: Overcoming the diagnostic delay via education
By Eylül GÜN
Although the diagnosis of endometriosis is still not timely even in adults, due to its common under- or misdiagnosis in adolescents, the diagnostic delay may further cause the adolescent women to wait to seek medical treatment. A group of researchers…
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Chemical Found in Self-Care Products May Be Linked to Endometriosis
By Özge Özkaya
There may be a link between exposure to phthalates and endometriosis according to a new study published in the Journal of Assisted Reproduction and Genetics. Although more research is needed, these findings could be translated into clinical practice according to…
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Transvaginal Ultrasound Accuracy for Uterosacral Ligament, Torus Uterinus and Posterior Fornix Endometriosis
By Selma Oransay
The accuracy of transvaginal ultrasonography for the diagnosis of deep endometriosis depends on the location. The sensitivity is up to 80% when the lesion is in the rectosigmoid, but it decreases up to 66% for the detection of posterior vaginal…
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The clues for pain and infertility in endometriosis/adenomyosis complex
By Nasuhi Engin Aydin
Drs. Gruber and Mechsner from Charite University-Berlin, Germany published their comprehensive review on pathophysiological background of endometriosis and adenomyosis in the scientific periodical “Cells”. Chronic pain and fertility problems are the main clinical issue in endometriosis and adenomyosis patients. In order to…
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Technical Facts for the Prevention of Complications After Deep Endometriosis Surgery
By Özge Özkaya
There are no differences in the risk of rectovaginal fistula in women with rectovaginal endometriosis who were managed by a liberal or restrictive policy of preventive stoma according to a study by French researchers published in the Journal of Minimally…
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Non-pharmacological self-care: dietary modifications in women with endometriosis.
By Selma Oransay
The academic interest on the role of diet in endometriosis has grown due to its possible relation with inflammation, estrogenic activity, and menstrual cycles. Multiple dietary strategies and prescriptions are being used to deal with the pelvic pain and gastrointestinal…
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How to measure the length of recto-sigmoid deep endometriosis reliably?
By Eylül GÜN
An in-depth assessment is needed when rectosigmoid deep endometriosis is decided to be treated surgically. Surgery carries a lot of risks and it is not always easy to decide which procedure the patient would benefit the most from. Patient-oriented surgical…
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A scoping review proposal for the diagnostic and treatment delay of endometriosis
By Hale Goksever Celik
Women with endometriosis suffer from pain for a prolonged time due to diagnostic and treatment delay which is the most challenging aspect of endometriosis. Cromeens et al, from the USA, published a review entitled “Timing, delays, and pathways to the…
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Strong Geographical Gradient in Endometriosis Incidence Identified
By Özge Özkaya
The geographical distribution of new endometriosis cases showed a very strong north-south spatial gradient in the highly industrialized Friuli Venezia Giulia region of Italy, according to a new study published in the International Journal of Environmental Research and Public Health. “The cluster of…
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Not just the pain stops but also the bowel function improves after DIE surgery
By Bahar Yuksel
Bowel endometriosis and the techniques to operate it have always been a challenge. The study conducted by Beraldo et al., from Brazil, highlighted the results of an effective nerve-sparing bowel surgery on endometriosis lesions and its long-term effects on patients. The…
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Exploring a bonafide biomarker to predict endometriosis
By Eylül GÜN
Endometriosis is a complex disease affecting many women in the reproductive age group. As it is important to figure out the mechanisms responsible for the disease, it is also crucial to identify biomarkers that can be used in the diagnosis…
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Promising therapeutic results in experimental endometriosis model
By Nasuhi Engin Aydin
Tiziana Genovese and associates from Italian academic centers reported their pioneering findings in an experimental model of endometriosis administering an anti-tumor agent and glucocorticoid combination, published in the scientific periodical “International Journal of Molecular Sciences”. Endometriosis is a worldwide common disease…
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It is not that simple: endometriomas are almost never alone
By Bahar Yuksel
Endometriomas are the widely and easily diagnosed type of endometriosis. They are usually treated by gynecologic surgeons and are thought to be alone most of the time. The study conducted by Piriyev et al highlighted the coexistence of extraovarian endometriosis…
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Is the presence of nerve fibers in the endometrium associated with endometriosis?
By Eylül GÜN
Endometriosis is a common disease in reproductive women and diagnostic imaging have a limited role in its diagnosis. The gold standard diagnostic method remains to be the histopathological examination of the tissue obtained via laparoscopy. One of its most common…
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Resveratrol, isoflavones and puerarin have favorable in vivo results in endometriosis studies
By Nasuhi Engin Aydin
Xia Cai and associates from research units located in China published their review article on the relationship between phytoestrogens and endometriosis in the scientific periodical named “Pharmacology”. The great variation in the prevalence of endometriosis raises questions in regard to…
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Endometriosis and Rheumatoid Arthritis, Could There Be a Link?
By Özge Özkaya
Patients with endometriosis have a higher risk of rheumatoid arthritis according to a study published in the journal Rheumatology. This finding suggests that rheumatologists should be especially mindful of the possibility of underlying endometriosis when treating women with rheumatoid arthritis.…
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Postoperative Opioid use after Robotic operations for endometriosis, compared to non-endometriosis
By Bahar Yuksel
Endometriosis is a common disease in patients of fertile age, and many patients require surgery. Robotic surgery is accepted as a minimally invasive method in the management of endometriosis and other benign conditions. However, postoperative pain status and the best pain…
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Ureteral endometriosis and its management
By Eylül GÜN
Urinary tract endometriosis prevalence is hard to determine since almost half of the women with this condition appear asymptomatic. The most common form is bladder endometriosis followed by ureteral endometriosis which is seen more rarely. Ureteral endometriosis is usually located…
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Does hyaluronic acid have a role in endometriosis?
By Nasuhi Engin Aydin
Pei-Hsiu Yu and associates from Tainan, Taiwan, published their results of original research on the role of hyaluronic acid in endometriosis formation in a recent issue of "Taiwanese Journal of Obstetrics and Gynecology". Hyaluronic acid, a glycosaminoglycan protein in the…
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Medical Examination Reduces Anxiety in Women With Suspected Endometriosis
By Özge Özkaya
Anxiety levels go down after medical examination in women with suspected endometriosis, found a study by Italian researchers that was published in the Journal of Psychosomatic Research. This was especially pronounced in women who had higher baseline distress and who…
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Analyses of the main classification systems of endometriosis in terms of utrasound, MRI and surgery
By Selma Oransay
Several classifications made by gynecologists, image readers, and radiologists lead to confusion while describing the situation and estimating the progress of endometriosis. Daniela Fischerova team from the Charles University of Prague, Czech Republic, analyzed the main classifications of endometriosis in three…
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Does exercise have an effect on pain perception in women with endometriosis?
By Hale Goksever Celik
Endometriosis is an inflammatory disease causing pain symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain, and also infertility. Several medical and surgical treatment options have been developed to improve quality of life of these women. Despite extensive research, the optimal…
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