By Selma OransayPostoperative pain-related quality of life for patiens with different types of endometriosis surgery.
By Selma Oransay
Endometriosis surgery usually improves chronic pelvic pain and the quality of life in women suffering from that disease. Response to surgery depends on several factors, however, in younger ages, recurrence of both pain and endometriosis lesions are reported. Most research…
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Current practice in robotic surgery for deep-infiltrating endometriosis
By Selma Oransay
Today, surgical excision of endometriotic lesions is the only cytoreductive procedure for managing endometriosis. Hormonal treatment may partly relieve the symptoms, but it suppresses rather than cytoreduction of the disease. Minimally invasive surgery is usually the most preferred method due…
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By Özge ÖzkayaDoes The Severity of Endometriosis Pain Affect the Chance of Having a Baby With IVF?
By Özge Özkaya
Severe pain symptoms in endometriosis have no relation with the outcomes of assisted reproductive techniques such as in vitro fertilization (IVF), according to a new study published in the journal Human Reproduction. This finding suggests that the decision-making process for…
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By Hale Goksever CelikPsychological effect of endometriosis due to chronic pelvic pain
By Hale Goksever Celik
The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, and chronic pelvic pain, all of which affect the quality of women’s lives. Early diagnosis and management are important as endometriosis impairs the quality of life of patients and creates a…
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Study Identifies Best Questionnaires to Assess Sexual Function in Patients With Endometriosis
By Özge Özkaya
The Female Sexual Function Index (FSFI) and the Sexual Activity Questionnaire (SAQ) have the best measurement properties according to the Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) criteria for the measurement of sexual function in women with endometriosis,…
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By Nasuhi Engin AydinHands-on proposals for medical counseling and verbalizations to use for women with endometriosis
By Nasuhi Engin Aydin
An overview has been published recently in the Archives of Gynecology and Obstetrics on patient–doctor communication and psychological counseling in endometriosis by two academicians, Drs. Wischmann and Ditzen, from Heidelberg University, Germany. There is no known cure for endometriosis and primary management…
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Are women with endometriosis more prone to have mental health disorders?
By Hale Goksever Celik
Endometriosis is a long-term morbidity resulting in impaired physical, sexual, psychological, and social health. The most common clinical findings of endometriosis patients are chronic pelvic pain and fertility problems, associated with impaired quality of life. These women are also affected…
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Fertility outcomes after discoid excision for colorectal endometriosis.
By Selma Oransay
Colorectal endometriosis is one of the most severe forms of deep endometriosis, composing 85% of all bowel lesions. Radical treatment is segmental resection of the bowels, which can cause postoperative severe complications such as rectovaginal fistula and voiding dysfunctions that negatively…
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What Happens to all Those Frozen Eggs?
By Özge Özkaya
The rate of return to use previously vitrified oocytes is notably low even though there is an increase in the number of patients pursuing oocyte cryopreservation, found a new study published in JAMA Network Open. According to the authors of…
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Spontaneous Conception After Deep Endometriosis Surgery
By Selma Oransay
Deep endometriosis is a severe form of endometriosis where lesions invade deeper than 5 mm into subperitoneal space. Surgical management of the disease is a challenging task requiring a multi-disciplinary approach and significant expertise in the field. Anastomotic leaks, fistula,…
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Neonatal uterine bleeding at birth and endometriosis later in life
By Selma Oransay
In the first few days after birth, some female newborns bleed from the vaginal route, and this is called newborn uterine bleeding. The overt and occult neonatal uterine bleeding prevalence rates are 3-5% and 25-60% retrospectively. The causative risk factors for…
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Could brain-derived neurotrophic factor (BDNF) be a potential marker of endometriosis ?
By Nasuhi Engin Aydin
Medical student Kyana Jafarabady and academicians from several medical centers in Iran have published their database research on Brain-derived neurotrophic factor (BDNF) in endometriosis patients in a recent issue of BMC Women’s Health. BDNF is a neurotrophin that plays an important…
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Should I Have Endometriosis Surgery Before IVF-ICSI?
By Özge Özkaya
The live birth rate per in vitro fertilization (IVF) or intrauterine sperm injection (ICSI) cycle was significantly reduced in women who underwent surgery to treat endometriosis before the procedures, found a new study published in the scientific journal Reproductive Sciences. “These…
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Bladder Function Alterations Following Endometriosis Surgery
By Selma Oransay
Although endometriosis is a common gynecologic disorder, urinary tract involvement is present in only 1-5% of these patients. When endometriosis invades the urinary tract, clinical symptoms may vary from asymptomatic to frequency, urgency, bladder pain, hematuria, and recurrent urinary infections.…
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By Eylül GÜNRisk of endometriosis and related occupational factors among working women
By Eylül GÜN
As a debilitating disease, endometriosis is well known to have effects on the patient's overall quality of life. Various studies have consistently reported that working women face an increased risk of endometriosis growth. Lee et al. from Korea conducted a…
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Ovarian adhesion prevention with polytetrafluoroethylene during endometrioma surgery.
By Selma Oransay
The World Health Organization defined infertility as the inability to conceive after 12 months of regular unprotected intercourse or after six months of fertility-focused intercourse. Depending on the chronic inflammatory character and causing adhesion formations within the peritoneum, endometriosis is…
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Why is there a higher risk of stroke for women with endometriosis?
By Eylül GÜN
Women diagnosed with endometriosis might face an increased susceptibility to stroke due to alterations in the levels of some molecules in their systems. Studies indicate that especially those undergoing hysterectomy/oophorectomy, have an approximately 30% higher risk of stroke. Dr. Mormile…
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Study Identifies Potential New Theraputic Target in Endometriosis
By Özge Özkaya
Lactate could drive the progression of endometriosis by upregulating the expression of a gene called HMGB1, according to a new study published in the Journal of Biomedical Research. This finding identifies novel targets for the prevention and treatment of endometriosis.…
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Perception of quality of professional healthcare in Italian patients with endometriosis
By Selma Oransay
According to the Italian Ministry of Health, the prevalence rate of endometriosis among women in their reproductive age is 10-15%. Many of them suffer from intense pain and a poor quality of life due to diagnostic delay. The average delay…
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Neurotrophins proposed as possible biomarkers for endometriosis
By Eylül GÜN
As the search for a good-quality biomarker in endometriosis continues, certain growth factors have been investigated for their roles in the pathophysiology of the disease. Neurotrophins, as regulators of neuronal development and survival, are also known to take part in…
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Diagnosis and the Treatment of Postmenopausal Endometriosis
By Selma Oransay
About 190 million women around the world are diagnosed with endometriosis. The majority of the cases are between 30 and 40 years of age. After menopause, the incidence of endometriosis declines to 2-5%, and it is more common in women…
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New developments in endometriosis from a molecular and cellular standpoint
By Eylül GÜN
Researchers are making significant progress in endometriosis regarding molecular and cellular research, with collaborative efforts by clinicians, scientists, surgeons, and biostatisticians. Laganà et al. from Italy wrote an editorial regarding the recent special issue called "Molecular and Cellular Advances in Endometriosis Research…
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The type of surgical approach compared to complications and recurrence for colorectal endometriosis
By Hale Goksever Celik
Women with endometriosis may have extension and infiltration of the intestine, called "colorectal endometriosis, in up to 12%. The main symptoms are alterations in bowel habits, pelvic pain, and/or infertility. The gold standard management option for colorectal endometriosis is surgical…
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Deep infiltrating endometriosis and postoperative pregnancy outcomes
By Selma Oransay
Although the current ESHRE guidelines state that there is no strong evidence to support surgical intervention to improve the spontaneous pregnancy rate in women with deep infiltrating endometriosis and advise Assisted reproduction technology irrespective of the severity of endometriosis, several studies…
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Monitoring eating behavior is important
By Selma Oransay
The relationship between dietary products and endometriosis gained interest after the recognition that a proper diet can improve pathological and physiological processes. There is also a belief that the benefits of some anti-oxidants may have a therapeutic effect on the…
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Sacral neuromodulation for endometriosis-related chronic pelvic pain
By Selma Oransay
Sacral neuromodulation is a therapeutic technique that involves electrical stimulation of a sacral nerve route to modulate a neural pathway. The device is an implantable neurostimulator, and the procedure is a minimally invasive procedure with good long-term outcomes. This technique…
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Hazardous substances in pollution and relationship with endometriosis.
By Selma Oransay
Vallée and colleguages. from the Department of Epidemiology and Public Health of Foch Hospital, France, recently published a narrative review about environmental pollution and its association with endometriosis in BJOG. They used the existing English literature to discuss the association…
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Robotic Surgery Not Linked With More Complications in Certain Cases
By Özge Özkaya
Robotic-assisted excision surgery to treat large rectal endometriotic nodules larger than 3 cm is not associated with a higher risk of complications following the operation compared to conventional laparoscopy, according to a new study published in the journal Colorectal Diseases.…
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Live Birth Rate for ovarian stimulation protocols after laparoscopic endometrioma cystectomy.
By Selma Oransay
The laparoscopic cystectomy of the ovaries is the first-line infertility treatment in patients with endometriomas. However, a possible diminished ovarian capacity after cystectomy with ovarian failure to respond to the gonadotropin stimuli seems an undesirable result of this procedure. Controlled…
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Perioperative complications of outpatient surgery for endometriosis.
By Selma Oransay
Surgical treatment of endometriosis plays an essential role in managing the disease. They are miscellaneous perioperative complications such as incomplete removal of the lesions, low quality of the first surgery, or incorrect approach to laparoscopic surgeries that result in increased…
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Comparison of two different surgical approach to deep colorectal endometriosis in terms of postoperative outcomes.
By Selma Oransay
Deep colorectal endometriosis affects one-fifth of women with endometriosis, which is commonly associated with more pelvic pain and severe gastrointestinal symptoms. Three surgical approaches for deep colorectal endometriosis are segmental colorectal resection, full-thickness discoid resection, and shaving operation. Choosing the…
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Endometrioma surgery and the ovarian reserve
By Selma Oransay
Traditionally, cystectomy is the gold standard for surgical approach owing to the reduced risk of recurrence. Still, it may lead to a reduction in postoperative ovarian volume and can be a cause of ovarian failure. The recent conservative surgical management of…
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Endometriosis and Physical Activity
By Hale Goksever Celik
Endometriosis causes abstinence from their daily life, especially during painful periods. Decreased physical function might result in reduced physical activity. Sachs et al., from Switzerland, published a study titled “Physical Activity in Women with Endometriosis: Less or More Compared with…
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Exploring endometriosis symptoms and their effects on women's lives
By Eylül GÜN
Endometriosis symptoms, their severity, and the way they affect patients' lives may vary. With the aim of investigating different personal experiences and perceptions of endometriosis symptoms and the way they impact women's daily lives, Hunsche and colleagues from Switzerland and…
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By Bahar YukselThe Molecular Mechanisms of how herbal medicine Actaea racemosa modulates Endometriosis Progression
By Bahar Yuksel
Increased proliferation, dysregulated apoptosis, and a pro-inflammatory and oxidative environment are the hallmarks of endometriosis. In the article published in the Journal of Molecular Sciences, penned by Livia Interdonato et al, the molecular mechanisms of the extract from a plant…
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Treatment of superficial dyspareunia using topical estrogens in postmenopausal women with a history of endometriosis
By Hale Goksever Celik
Genitourinary syndrome of menopause is defined as a collection of symptoms and signs caused by hypoestrogenic changes to the labia majora/minora, clitoris, vestibule/introitus, vagina, urethra, and bladder that occur in menopausal patients. Sexual dysfunction and superficial dyspareunia can be experienced…
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A comparative analysis of male and female perspectives on sexuality in couples dealing with endometriosis
By Eylül GÜN
Sexual relationships of patients with endometriosis have been an area of research lately, however, studies have focused mostly on female perceptions and opinions leaving out the males. Helfenstein et al. from Switzerland, Germany, and Austria conducted a multicenter cohort study…
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Is continuous hormonal treatment safe and healthy method for endometriotic patients?
By Selma Oransay
One of the studies related to the search for new markers in pathophysiologic causes of endometriosis is circulating microparticles and their subset "tissue factor". In response to damage, activation, or apoptosis, these microparticles are found in human plasma, urine, saliva,…
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Toxic metal cadmium and Endometriosis
By Nasuhi Engin Aydin
Data analyst Mandy Hall and and colleagues from the Department of Epidemiology and Biostatistics, Michigan State University, USA, have published their results on cadmium levels and endometriosis in a recent issue of “Human Reproduction”. In 2020 the World Health Organization…
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Moderate-to-severe Endometriosis and "The Cumulative live birth rate" in IVF Cycles
By Hale Goksever Celik
Infertility is one of the major symptoms in women with endometriosis. The incidence of endometriosis is approximately 10% in reproductive-aged women and up to 40-50% in infertile women. There are multifactorial mechanisms resulting in endometriosis-associated infertility such as anatomic distortion, impaired…
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"Transumblical single-port laparoscopy" for deep infiltrating endometriosis.
By Selma Oransay
Deep infiltrating endometriosis patients have multi-system involvements, severe pelvic adhesions, and pelvic pain. Dyspareunia, dysmenorrhea, infertility, gastrointestinal symptoms, and lower urinary tract symptoms seriously affect their quality of life. Although hormonal therapy may be the first choice for treating endometriosis,…
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Dienogest versus combined oral contraceptives treatment in postoperative endometriosis care
By Selma Oransay
Dienogest is a synthetic progestin derivative, like oral contraceptives, used to prevent endometriosis recurrence after surgery. Randomized clinical trials verified a significantly higher reduction in endometriotic lesions, clinical symptoms, and improved quality of life obtained when dienogest was given to…
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A Starch-Based Gel Barrier Reduces Pain and Improves Fertility After Endometriosis Surgery
By Özge Özkaya
The development of pain was reduced in women with endometriosis who underwent surgery for deep infiltrating endometriosis (DIE) resection and the "gel barrier 4DryField® PH" was used during the operation, according to results from a randomized controlled trial. Moreover, fertility was improved. "4DryField® PH"…
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Are women with endometriosis more prone to pregnancy loss?
By Hale Goksever Celik
Endometriosis is a gynecological disease of reproductive-aged women who may suffer from reproductive outcomes such as infertility, miscarriage, and recurrent pregnancy loss. Pregnancy loss is the spontaneous loss of a pregnancy until 22 weeks of gestation including spontaneous abortion, missed…
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Telemedicine for endometriosis
By Eylül GÜN
The COVID-19 pandemic led to the widespread adoption of telemedicine, allowing healthcare professionals to provide care remotely using technology. Telemedicine has proven successful in various medical fields. In obstetrics and gynecology, implementing telemedicine became crucial, especially for conditions like endometriosis.…
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Postoperative outcomes of laparoscopic rectosigmoid resection for bowel endometriosis.
By Selma Oransay
Rectosigmoid endometriosis comprises 80-85% of all bowel endometriosis cases and can be localized in the rectovaginal septum, uterosacral ligaments, retro-cervical region, and parametrium. Symptoms of rectosigmoid endometriosis include abdominal bloating, constipation-diarrhea, lower-back pain, dyschezia, and sometimes cyclic rectal bleeding. Minimally…
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Sexual activity during menstruation: Any impact on endometriosis development?
By Eylül GÜN
Retrograde menstruation is among the theories for the etiology of endometriosis and there is a hypothesis that sexual activity during menstruation could potentially increase retrograde menstruation, leading to the implantation of endometrial tissue in other areas and consequently increasing the…
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Outcomes of chronic pelvic pain after niche repair
By Selma Oransay
Rapidly increasing cesarian section rates in recent years increased the cesarian scar defects and the development of "isthmoceles". Isthmocele is a myometrial lesion located around the isthmic portion of the uterus that is a myometrial discontinuity or hypoechoic triangle in…
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Changes over time in day surgery for endometriosis in Canada
By Hale Goksever Celik
There are several medical and surgical treatment options for the management of endometriosis. Surgical approach is generally preferred in women with atypical endometrioma appearance on ultrasound, and who have persistent pain despite medical treatment. Surgery is often the first choice…
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Menopause-management strategies for women with endometriosis.
By Selma Oransay
Menopausal hormonal therapy is the most effective treatment for menopausal symptoms, such as hot flushes, sweating, sleep disturbances, mood changes, and joint pain. Approximately 75% of all women experienced some degree of these symptoms, while 2-4% were diagnosed with endometriosis. Menopausal…
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When to start ART after laparoscopic treatment of endometriosis?
By Selma Oransay
Laparoscopy combined with histopathologic confirmation of endometriosis is the reference standard for diagnosing endometriosis. Additionally, laparoscopic surgery is considered the most effective way to approach infertility induced by endometriosis. The surgical factors influencing the outcome of treating the infertility of…
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The cost-effectiveness of different GnRH agonist regimes for progestogen-resistant endometriosis.
By Selma Oransay
Surgical and medical treatments are currently used to treat the pelvic pain caused by endometriosis. Respected guidelines recommend using progestins with or without estrogens as first-line medical treatment due to their safety, effectiveness, inexpensive, and tolerability. However, one-third to one-quarter…
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The effect of dienogest vs ethynyl estradiol/dienogest on quality of life in women with endometriosis
By Hale Goksever Celik
Women with endometriosis suffer from dysmenorrhea, dyspareunia, and chronic pelvic pain that diminishes the quality of their life. Both physical and mental components of quality of life have been affected by endometriosis-associated symptoms. There are several medical and surgical treatment…
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Ultrasonographic findings predicting parametrial deep endometriosis
By Selma Oransay
Transvaginal ultrasonographic evaluation is the primary imaging technique to rule out deep endometriosis. Although the International Deep Endometriosis Analysis Group (IDEA) published a consensus to standardize the nomenclature of ultrasonographic pelvic examination in women with suspected deep endometriosis, parametrial deep endometriosis…
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Surgery for Deep Endometriosis
By Selma Oransay
In recent years, minimally invasive surgery has gained popularity, providing the best results in gynecologic cancers and deeply infiltrated endometriosis. With the help of a high-definition camera displayed on a TV monitor, the small structures are enlarged 4-7 times and…
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Integrative medical management of endometriosis
By Selma Oransay
This lecture entitled "Integrative Medical Management of Endometriosis" was presented by Dr. Pinar Kodaman, Director of the endoscopic reproductive surgery program and Assoc. Professor of Clinical ObGyn and Reproductive Sciences at the Yale School of Medicine. In addition to surgery which…
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Which surgery for deep endometriosis? Laparoscopic shaving or rectal resection?
By Selma Oransay
This keynote lecture entitled "Deep endometriosis: The place of laparoscopic shaving" was presented by Dr. Jacques Donnez, the director of the infertility research unit at the Catholic University of Louvain, Brussels, Belgium, at the Annual International Medical Conference of the Endometriosis Foundation…
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Is there any advantage of addition of hysterectomy on deep endometriotic pelvic pain or on the quality of life?
By Selma Oransay
The addition of hysterectomy and salpingo-oophorectomy to the endometriosis excision surgery provided greater benefits when compared to excision surgery alone, according to the results of a comparison study that was recently published in the journal named "Facts Views and Visions in Obstetrics…
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Antioxidant astaxanthin has promising effects on endometriosis-related infertility.
By Nasuhi Engin Aydin
Dr. Rostami and colleagues from the Tehran University of Medical Sciences, Iran, have published a pioneering clinical study on the effects of antioxidant astaxanthin supplementation in infertile endometriosis patients in the scientific journal named Frontiers in Endocrinology. A complicated network…
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How to cope with the probable complications of Laparoscopic Hysterectomy
By Özge Özkaya
Laparoscopic hysterectomy to treat endometriosis and adenomyosis can lead to complications, which are “non-negligible”, according to a new study published in the Journal of Minimally Invasive Gynecology. It is, therefore, of great importance to know the factors that are associated…
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First-line surgery or first-line ART: A real challenge both for the clinicians and infertile women having DIE without colorectal involvement
By Hale Goksever Celik
Deep infiltrating endometriosis (DIE) is defined as the presence of endometriotic lesions over 5 mm in depth under the peritoneal surface. These women suffer from chronic pelvic pain, dysmenorrhea, dyspareunia, chronic pelvic pain, bloody or painful bowel movements, and infertility. There…
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Serum Galectin-9 : A promising marker for endometriosis diagnosis
By Nasuhi Engin Aydin
Dr. Jarollahi and colleagues from Iran University of Medical Sciences, Tehran have published their research on serum levels of Galectin-9 as a noninvasive marker for endometriosis in the "Journal of Reproduction & Infertility". Endometriosis imposes a great challenge in the…
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The enhanced invasiveness, migration and the development of adenomyosis: Importance of M2 macrophages
By Hale Goksever Celik
Adenomyosis is the ectopic presence of endometrial stromal and glandular cells inside the myometrial tissue. Adenomyosis is diagnosed in women with gynecological problems with an incidence of 20%, although it is encountered much more frequently in hysterectomy specimens. Among many…
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Does Endometriosis Surgery Increase the Rate of Pregnancy?
By Özge Özkaya
Surgery to treat colorectal endometriosis leads to a high rate of pregnancy following the operation, found a new study published in the Journal of Minimally Invasive Gynecology. The authors of the study said, “studies with a high level of evidence…
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A review of multimodal imaging modalities for endometriosis.
By Selma Oransay
Since there is a lack of non-invasive biomarkers to diagnose endometriosis clinically, imaging techniques such as transvaginal ultrasonography and MRI have significant importance in preoperative endometriosis diagnosis. These imaging techniques allow appropriate surgical planning before laparoscopic excision, especially in deeply…
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Antiinflammatory lactoferrin molecule and antibody levels in endometriosis patients
By Nasuhi Engin Aydin
A Japanese clinical research team led by Dr. Kaya Mori-Yamanaka from Shiga University of Medical Science Hospital, Otsu, Shiga, Japan, published their pioneering study on the role of serum lactoferrin and anti-lactoferrin antibody levels in endometriosis in a recent issue of…
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Laparoscopic resection of bladder endometriosis
By Selma Oransay
When we talk about deep-infiltrating endometriosis, one of the most commonly affected organs in the urinary tract is the bladder, with a prevalence of 80%. Bladder endometriosis can be defined as the existence of the endometrial glands and stroma inside…
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Postoperative pregnancy outcomes in women with deep infiltrating endometriosis
By Hale Goksever Celik
Subperitoneal invasion of endometriotic lesions exceeding 5 mm in depth is named "deep infiltrating endometriosis' and can be located on uterosacral ligaments, in the intestine, vagina, bladder, and ureter. Women with deep infiltrating endometriosis suffer from pelvic pain and infertility most…
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From Finland : How to increase health issues in endometriosis patients
By Nasuhi Engin Aydin
Dr. Henna-Riikka Rossi and associates from the University of Oulu, Oulu, Finland have published their recent prospective cohort study on possible existing comorbidities of endometriosis patients in the journal Fertility and Sterility. Endometriosis is an estrogen-dependent chronic ailment affecting about…
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How Good is Ultra-Long GnRH-a Treatment Before IVF for Women With Endometriosis?
By Özge Özkaya
Pretreatment with ultra-long gonadotropin-releasing hormone agonist (GnRH-a), i.e. for at least three months before in vitro fertilization (IVF), has an adverse effect on patient pregnancy outcomes with endometriosis, according to a meta-analysis of the literature published in the Journal of…
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Comparison of different IVF stimulation protocols for pregnancy success in infertile endometriosis patients
By Hale Goksever Celik
Women with endometriosis may suffer from reproductive problems up to an incidence of 50%. Several pathophysiological mechanisms including anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis and sperm movements are the most responsible for the development of endometriosis-associated infertility.…
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Hypoxia and endometriosis: A review of mechanisms
By Eylül GÜN
Various mechanisms have been suggested to explain the development of endometriosis lesions. One of these is hypoxia, which can induce changes in endometrial cells, but the exact mechanism is not yet clear. Zhou et al from China wrote a review…
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The effectiveness of acupuncture in the treatment of dysmenorrrhea
By Selma Oransay
Asymptomatic endometriosis does not adversely affect women's quality of life and mental health. But the quality of life of women with endometriosis who suffer endometriosis-related pelvic pain, dysmenorrhea, dyspareunia, and dysuria declines as they become more susceptible to anxiety and…
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Myofascial pain management and endometriosis
By Bahar Yuksel
Endometriosis is an inflammatory disease that causes inflammation around pelvic muscles and peripheric nerves which ultimately may cause peripheral and central sensitization and result in increased response to pain. In the study conducted by Shrikhande at al. from the pelvic…
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Conventional IVF or ICSI: Which one is more accurate in endometriosis-related infertility?
By Hale Goksever Celik
Although the prevalence of endometriosis is 10-15% in the general population at reproductive age, it is diagnosed more frequently in infertile women with a prevalence of 25-40%. Although the exact mechanism explaining the association between endometriosis and infertility has not…
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Women With More Severe Endometriosis Have Fewer Eggs
By Özge Özkaya
Severe endometriosis negatively affects ovarian response and the quality of oocytes and embryos, according to a new study published in JBRA Assisted Reproduction. However, the rate of fertilization does not seem to be affected by endometriosis stage. These findings could…
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Sexual function in infertile women with PCOS and endometriosis
By Hale Goksever Celik
Women with endometriosis suffer from several symptoms and signs including dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility which have a detrimental effect on their quality of life. Sexual dysfunction also is a common problem for endometriosis patients due to complex…
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Gastrointestinal symptoms in colorectal deep endometriosis
By Eylül GÜN
The colon, particularly the recto-sigmoid is the most commonly involved area in deep endometriosis. These patients suffer from gastrointestinal symptoms almost as much as pelvic pain symptoms the most common being reported as frequent and painful defecation. Gastrointestinal symptoms may…
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Endometriosis and the body perception
By Hale Goksever Celik
The most common endometriosis-associated symptoms are pelvic pain, dysmenorrhea, dyspareunia, and infertility. Women with endometriosis should be managed due to the significant impact of these symptoms on their quality of life. Body perceptions of these women are also affected depending…
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Creating a reliable indirect immunofluorescence protocol as a promising diagnostic tool for endometriosis
By Eylül GÜN
Owing to its inflammatory nature, endometriosis results in the overproduction of reactive oxygen species (ROS) which disrupt the cellular functions and eventually lead the cell to apoptosis and cell cycle arrest. Senescence, the natural state of irreversible cell cycle arrest,…
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Ovarian endometriomas, ovarian reserve, oocyte quality and IVF/ICSI outcomes
By Selma Oransay
Surgery and assisted reproductive technology (ART) are the preferred treatments for endometrioma in infertile patients. When ART is considered, surgery may seem to have no advantages, as it may not improve pregnancy outcomes and may carry the risk of decreasing…
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Obstetric Outcomes of Pre-pregnancy Endometriosis Surgery
By Selma Oransay
Endometriosis may be associated with poor pregnancy outcomes, including placenta praevia, preterm birth, premature prelabour rupture of membranes, obstetric hemorrhage, gestational hypertensive disorders, fetal growth restriction, and perinatal death. Some authors have attempted to demonstrate a causal relationship between endometriosis…
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Foreseeing what will be seen on laparoscopy
By Bahar Yuksel
Endometriosis diagnosis still relies on preoperative prediction and its confirmation by taking biopsies. Thus, a prediction model for forecasting what would be waiting for the surgeon and the patient will be promising to get prepared. In the study conducted…
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Deep lateral parametrial endometriosis nerve-sparing surgery
By Selma Oransay
Dr. Kanno et al. from the Department of Obstetrics and Gynecology of Kurashiki medical center, Okayama, Japan recently published a deep lateral parametrial endometriosis case report in the journal named Fertility and Sterility. The aim is to demonstrate the technical and…
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How beneficial is colorectal surgery for patients with deep endometriosis?
By Eylül GÜN
In cases of deep endometriosis, which causes more severe pain and gastrointestinal symptoms, the patient's quality of life and fertility outcomes are negatively affected. Surgical intervention is thought to be the optimal treatment method in colorectal deep endometriosis cases, however,…
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Postoperative serum markers to predict serum AMH recovery following endometriosis surgery
By Hale Goksever Celik
Women with endometriosis seek treatment including ovarian cystectomy, because of symptoms that reduce their quality of life. Ovarian cystectomy using laparoscopic or robotic devices is the preferred therapy. However, it has been shown in the literature that ovarian reserve is…
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Social Support is a Predictor of Resilience in Women with Endometriosis
By Özge Özkaya
Satisfying social support and good mental health are key resources for resilience among patients with endometriosis, according to a new study published in the Journal of Clinical Medicine. “The results of this study may assist in the identification of women…
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Endometriosis Increases Risk of Sexual Dysfunction But Only Before Menopause
By Özge Özkaya
Endometriosis increases the risk of sexual dysfunction, found a new study by US scientists. But this is the case only before menopause. This finding can guide doctors in decision-making about evaluating the sexual function of women with endometriosis who have…
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Taller Girls More Likely to Have Recurring Endometriosis
By Özge Özkaya
Adolescents who are taller and have three or more lesions are at a higher risk of endometriosis recurrence following surgery, according to a new study by Chinese researchers published in the Journal of Obstetrics and Gynaecology. They should, therefore, be…
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A prediction model to identify endometriosis during routine ultrasound .
By Selma Oransay
. Ureterolysis is an advanced surgical technique that involves dissection of the ureter from pelvic brim to the ureteric tunnel to avoid injury or freeing the ureter from endometriotic lesions. This manipulation usually requieres advanced surgical training and skill. In…
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Parametrial endometriosis and postoperative voiding dysfunction.
By Selma Oransay
Parametrium constitutes a complex connective tissue containing blood vessels, the ureter, and the inferior hypogastric plexus, that extends from the lateral surface of the cervix and vagina to the lateral pelvic wall. Parametrial endometriosis may involve the vessels, nerves, and…
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Turn around to come to the same spot: Nothing specific to predict AMH decline
By Bahar Yuksel
Endometriomas are challenging lesions as they might cause a decline in ovarian function either only by their presence or related to their surgery. Thus, any preoperative parameter that might give a vision to a surgeon for postoperative results is crucial.…
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A call for mast cells from endometriotic lesions
By Bahar Yuksel
Endometriosis is a well-known hormonal-dependent inflammatory disease. But what type of inflammatory cells is responsible, and when does estrogen take part, are questions that have not been answered yet. In the study conducted by Alison McCallion et al, the role…
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Study Identifies Factors Associated With Risk of UrinaryTract Endometriosis Recurrence
By Özge Özkaya
Being younger than age 25 and having an autoimmune disease are significant predictors of the recurrence of urinary tract endometriosis after surgery according to a new study published in the Journal of Minimally Invasive Gynecology. Adjuvant hormonal therapy, on the…
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To Remove the Ovary(ies) or Not During Hysterectomy for Endometriosis
By Selma Oransay
Some surgeons prefer empiric bilateral salpingo-oophorectomy during the hysterectomy of women with endometriosis based on the knowledge that endometriosis is stimulated by endogenous estrogens, as leaving the ovaries in situ may increase the possibility of endometriosis recurrence and pelvic pain.…
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Sex Education For The Sexual Quality Of Life
By Hale Goksever Celik
The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Decreased quality of life due to pelvic pain, dyspareunia, and psychological conditions such as anxiety and depression can lead to sexual dysfunction in women with endometriosis.…
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Endometriosis-associated infertility: How to manage?
By Hale Goksever Celik
Although the underlying reason for endometriosis has not been fully established, there is an association between endometriosis and infertility. Endometriosis is thought to be involved in 40-50 percent of infertility cases. However, natural conception can still occur even in women…
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A new potential therapeutic target in endometriosis: Galectin-3
By Eylül GÜN
The endometrial cells migrate and attach to the peritoneal surface according to the most widely accepted retrograde menstruation theory in endometriosis development. Given that only 10% of women have endometriosis, it is thought that some additional factors contribute to the…
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Understanding the expression of endometriosis-related pain: A barrier to overcome
By Eylül GÜN
It is difficult to describe the feeling of pain, one of the most important symptoms of endometriosis because it is subjective. Endometriosis-related pain is proven to be underestimated by some clinicians resulting in the patient getting a late diagnosis. It…
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Postoperative outcomes of deep intestinal endometriosis surgery.
By Selma Oransay
Invasion of endometriotic lesions to the bowels' mucosal and/or muscular levels is called intestinal deep endometriosis. These lesions are most frequently found in the rectosigmoid colon, followed by the rectum, ileum, appendix, and caecum. The optimal surgical approach to intestinal deep…
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The accuracy of transvaginal ultrasound and magnetic resonance imaging for deep urinary tract endometrisis.
By Selma Oransay
The prevalence of urinary tract endometriosis is 19-53% in patients within deep infiltrating endometriosis cases. The bladder and ureteral are the most common sites of the involvement. While preparing a radical surgery for a patient with deep endometriosis, the diagnosis…
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Endometriosis in transmasculine people
By Eylül GÜN
“Transmasculine” refers to people who were assigned female at birth but later identify themselves with masculinity. If they choose to transition to the male gender, they are then prescribed long-term testosterone and some may want to undergo a hysterectomy as…
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Chronic pelvic pain and endometriosis
By Selma Oransay
Patients may have an average of 7 clinical visits before being diagnosed with endometriosis. Understanding chronic pain conditions including endometriosis-associated pain, and developing chronic pelvic pain benefits the management of the patients. The role of central sensitization, comorbid conditions, and…
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Who Is Diagnosing my Endo?
By Özge Özkaya
It is possible to acquire the skills necessary to diagnose endometriosis lesions as well as adenomyosis using three-dimensional rectosonography after a short learning period in an expert radiology center. This is according to a new study by French researchers published…
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Surgery Improves the Sex Life and Sleep of Women With Endometriosis
By Özge Özkaya
Endometriosis surgery improves patients’ quality of life, sexual function, and sleep confirms a new study by Turkish researchers published in the scientific journal Archives of Gynecology and Obstetrics. According to the first author Dr. Belfin Nur Arici Halici of the…
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How does endometriosis affect the life course of the patients?
By Eylül GÜN
Endometriosis, as a chronic disease has impairing effects on women’s lives. Patients carry psychological, social, and work-related burdens along with debilitating physical symptoms. Studies have been performed on these issues at a particular time in patients’ lives, however, only a…
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The evaluation of sexual dysfunction in infertile women
By Eylül GÜN
Infertility constitutes a serious health problem in women and men worldwide. The most common causes of women’s infertility are reported to be endometriosis and polycystic ovarian syndrome. The prevalence of infertility in women with endometriosis is as high as 50%.…
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Comparison of imaging techniques for estimating the depth of bowel wall infiltration by endometriosis.
By Selma Oransay
The surgical removal of deep endometriosis is the cornerstone of the management. However, the decision for the varying surgical approach types ranging from conservative management (shaving) to segmental or discoid resection depends on the depth of infiltration within the bowel wall, which…
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Geography May Influence Risk of Endometriosis
By Özge Özkaya
The risk of developing endometriosis seems to be geographically heterogeneous across France, according to results from a study published in the journal Scientific Reports. The study identified 20 high-risk hotspots around the country. These showed similar results for non-adenomyosis endometriosis…
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Abdominal wall endometriosis is not a rare disease as supposed
By Hale Goksever Celik
Abdominal wall endometriosis is an iatrogenic type of endometriosis defined as the localization of endometrial glandular and stromal tissue on the abdominal wall including skin, the rectus abdominis muscle, and rectus muscle sheath. Cyclical pain, mass located on the abdominal…
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The incidence of ovarian cancer after histologically diagnosed endometriosis.
By Selma Oransay
Ovarian cancer has the highest mortality rate among gynecologic cancers. Furthermore, these patients are generally diagnosed in advanced stage due to their non-symptomatic nature. Therefore, preventative strategies have enormous importance for the management of ovarian cancer. Dr. Hermens and colleagues…
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Which of the suggested environmental risk factors are indeed related to endometriosis?
By Eylül GÜN
Endometriosis is a complex disease with genetic and environmental factors in its poorly understood pathogenesis. Even though many epidemiological studies in the literature have proposed several risk factors, the lack of clear establishment and modification of these potential risk factors…
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Endometriosis diagnosis and management based on the best available evidence from published literature
By Selma Oransay
ESHRE, "European Society of Human Reproduction and Embryology" published a Guideline for the diagnosis and treatment of endometriosis in 2005 and then revised it in 2013. Based on new research and development there was a need to renew the last…
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What are the most common symptoms of endometriosis and how are they related to age?
By Eylül GÜN
Even though the incidence of endometriosis is relatively high and numerous studies are being conducted to elucidate its pathogenesis, it is still a highly underdiagnosed and undertreated disease. The symptoms of the disease are well-known; however, the correlation between the…
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A revolutionary view on endometriosis related pain
By Nasuhi Engin Aydin
Dr. Lydia Coxon and colleagues from Oxford University, UK, have recently published their cross-sectional study on the categorization of endometriosis-related pain in the journal "Frontiers in Pain Research". As a chronic inflammatory condition, endometriosis results in pelvic pain, dysmenorrhea, and…
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Planning surgery for recto-sigmoid endometriosis with 3D virtual models.
By Selma Oransay
Efforts to reduce the high complication rate of rectosigmoid surgery in deeply infiltrated endometriosis are of great interest to gynecologists. 3D printing, currently used in various surgical specialties to support surgical planning and guide intraoperative procedures may be a way…
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Prolactin receptor antibodies: A novel treatment proposal for endometriosis
By Eylül GÜN
Prolactin, a hormone that also acts as a proinflammatory cytokine through its receptor PRLR has been shown to be involved in endometriosis pathogenesis. Previous studies reported that women suffering from endometriosis had elevated prolactin levels. Also, in experimental studies done…
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Imaging Techniques Able to Predict Depth of Endometriosis Before Surgery
By Özge Özkaya
Transvaginal ultrasound (TVUS) and pelvic magnetic resonance imaging (MRI) performed by a specialist can accurately predict the depth of rectosigmoid endometriosis before surgery, according to a new study published in the Journal of Minimally Invasive Gynecology. Both approaches are similar…
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A novel scoring tool to standardize surgical complexity for gynecologists.
By Selma Oransay
The field of gynecologic surgery needs a more comprehensive, objective, and reproducible method for assessing and communicating surgical complexity than the current approach. Actually, there is no formal image-based system that allows surgeons to categorize and communicate the complexity of…
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A novel approach to a common lesion: mapping adenomyosis by imaging modalities
By Nasuhi Engin Aydin
Dr. Habiba from Leicester, UK, and Dr. Benagiano from Rome, Italy, have published their overview on adenomyosis in an attempt to set light on a clinically important topic in a recent issue of the "International Journal of Environmental Research and…
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Diaphragmatic defects, liver herniations and catamenial pneumothorax
By Nasuhi Engin Aydin
Dr. Arakawa and associates from The Jikei Katsushika Medical Center, Japan, have published their recent case of catamenial pneumothorax with diaphragmatic defect and liver herniation in the "Journal of Cardiothoracic Surgery". Catamenial pneumothorax is an uncommon condition with a reported…
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Diaphragmatic endometriosis
By Selma Oransay
Diaphragmatic endometriosis is a rare clinical condition that may show signs and symptoms like chest pain, right upper quadrant abdominal pain, shoulder pain, pleuritic pain, hemothorax, pneumothorax, hemoptysis, and thoracic endometriosis syndrome while the major part of the patients is…
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Urinary Tract Endometriosis
By Bahar Yuksel
Endometriosis is mostly seen in patients of fertile age, and urinary tract endometriosis affects 1.2 to 6% of women with endometriosis. French coloRectal Infiltrating ENDometriosis Study (FRIENDS) group investigated the characteristics of urinary tract endometriosis in 232 patients from 31 centers. Authors…
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Which surgical technique is best for rectal endometriosis?
By Eylül GÜN
One of the common sites for deep endometriosis is the intestines, with a rate of 3-37%. Intestinal endometriosis constitutes a serious cause of gastrointestinal symptoms, pain, and the alteration of the quality of life, with the rectum and sigmoid colon being…
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Nerve-sparing technique for deep infiltrating endometriosis and its impacts on pelvic organ and sexual functions.
By Selma Oransay
Deep infiltrating endometriosis and involvement of parametrium cause severe pelvic pain and dysfunction of some pelvic organs resulting in a reduction in women's quality of life. Although surgery for DIE aims to relieve pelvic pain, entering into the posterior parametrial…
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Effects of Bowel Endometriosis Surgery on Mode of Delivery
By Özge Özkaya
Less than a third of doctors counsel women about the possible effects of surgical treatment of bowel endometriosis on their mode of delivery should they become pregnant, according to a new study published in the Journal of Obstetrics and Gynaecology.…
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Egg or chicken, which is causing bladder symptoms, DIE or surgery for DIE?
By Bahar Yuksel
Urinary symptoms could be overwhelming and sometimes could be hidden behind pain symptoms, but still might cause secondary damages on kidneys and bladder if remain undetected. In the prospective study conducted by Laterza et al, the authors questioned whether the…
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The necessity of laparoscopy for unexplained infertility.
By Selma Oransay
The standard for accepting a couple as "infertile" is the inability to conceive after 12 months of regular unprotected intercourse. When this condition is met, assessing the number of motile sperm in the male partner and certifying the patency at…
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Physical activity and exercise in reducing endometriosis symptoms
By Eylül GÜN
The treatment modalities to date on endometriosis have focused on the symptomatic relief and management of chronic pain. Hormonal suppression sometimes shows intolerable side effects and is known to lose effect after some time. Surgical interventions may not provide a…
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Is it iron that calls vessels to form endometriosis
By Bahar Yuksel
The trigger mechanism of endometriosis formation is still under investigation. But it is clear that there is an iron overload on endometriotic lesions. In the study conducted by Guojing Li et al, the mechanism of iron on endometriosis formation has been…
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Machine learning tools to predict endometriosis
By Bahar Yuksel
The current gold standard diagnostic method for endometriosis is the surgical diagnosis and yet no approaches have been found to replace it. In the study conducted by Sofiane Bendifallah et al, the authors aimed to use machine learning algorithms to…
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The relevance of mitosis in endometriotic tissue biopsies
By Nasuhi Engin Aydin
Dr. Wetzk and co-workers from the Technical University, Dresden, Germany have published a retrospective study on the diagnostic impact of mitotic activity in the endometriotic lesion biopsies in the recent issue of the journal “Geburtshilfe und Frauenheilkunde”. Guidelines highly recommend a…
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Which one is more effective for the preservartion of postoperative ovarian reserve?
By Selma Oransay
Although cystectomy is the most preferred treatment of endometrioma, it is still a matter of debate as it may cause a reduction in the quality and number of remaining follicles, especially important for women who are planning to conceive. Anti-Müllerian…
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Placenta praevia and cesarean section more common in patients with ART for Endometriosis
By Hale Goksever Celik
Even though endometriosis is known to be associated with infertility, these women still have a chance to get pregnant spontaneously or by assisted reproduction techniques (ART) with the aid of recent technological developments. A It has also been shown that…
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Endometriosis and women’s social lives, work and education.
By Hale Goksever Celik
The women with endometriosis present with a broad clinical spectrum including pelvic pain, dysmenorrhea, dyspareunia, and infertility. All of these symptoms and signs may have a negative impact on women’s lives by having endometriosis. Mastrangelo and Turnbull, from Australia, published…
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Sexual Function in Women With Endometriosis
By Özge Özkaya
The sexual function of women diagnosed with endometriosis is impaired confirmed a new study by Spanish researchers published in the Journal of Clinical Medicine. According to the study, the strongest predictive factors for poor sexual function are deep disease, depression,…
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Relationship Goals and Sexual Satisfaction for Couples Coping with Endometriosis
By Selma Oransay
"Relationship satisfaction" is based on an individual's emotional judgment. Physical and emotional obstacles may present and negatively affect relationship satisfaction. Endometriosis is associated with multiple life domains, and also includes relationship and sexual satisfaction. Sexual satisfaction, on the other hand,…
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A plea from pathologists: standardized protocols for adenomyosis and endometriosis
By Nasuhi Engin Aydin
Pathologist Drs. Camboni and Marbaix from Brussels, Belgium published their comprehensive review on adenomyosis and endometriosis titled “Ectopic endometrium: the pathologists’ perspective” in a recent issue of the International Journal of Molecular Sciences. Endometriosis and adenomyosis are well-known entities as…
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The effect of hormone therapy after surgical menopause on endometriosis recurrence
By Selma Oransay
Definitive surgery for severe and advanced endometriosis is hysterectomy with bilateral oophorectomy, which may cause vasomotor symptoms, sleep deprivation, mood change, and dyspareunia in the patients. Furthermore, after the surgical removal of the ovaries, the sudden drop in estrogens causes…
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Life quality improves after colorectal endometriosis operation even when the gastrointestinal symptoms persist
By Bahar Yuksel
Colorectal endometriosis represents a catastrophic picture for patients, and the treatment mostly requires difficult operative techniques. The life quality improvement ratios are important before deciding on an operation. In the study conducted by Horace Roman et al, the life quality…
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Environmental factors play a role in the development of endometriosis
By Hale Goksever Celik
The proposed mechanisms underlying the development of endometriosis may be classified into three groups: in-situ theory, implantation theories, and induction theories. Genetic, hormonal, environmental, and lifestyle-related factors are also involved as no mechanism is solely responsible for endometriosis development. Although there are…
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Urinary Function Alterations after Surgery for Deep Endometriosis.
By Selma Oransay
Laparoscopic surgery is a mainstay therapy for symptomatic patients with DE. Although our findings of improvement in many domains of urinary function are encouraging, postoperative deterioration in urinary function was found for patients with initial normal function. More research is…
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Endometriosis Increases the Risk of Premature Labor Study Reports
By Özge Özkaya
Women with endometriosis who conceive naturally are at a high risk of giving birth prematurely and having their baby admitted to neonatal intensive care unit, compared to women without the disease, according to the results of a clinical study. The…
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Persistence of Chronic Pelvic Pain after Hysterectomy
By Hale Goksever Celik
Chronic pelvic pain is defined as the "pain in the pelvic area that lasts for 6 months or longer". There are several gynecological, urological, and gastrointestinal reasons for the development of chronic pelvic pain. Nociceptive pain or central sensitization is…
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Improvement of sexual-life quality in patients with endometrioma
By Bahar Yuksel
Endometriosis is a painful disease that affects daily life as well as sexual life quality. In the study conducted by Yalcin Bahat et al, the researchers questioned the effect of periodic use of dydrogesterone on the sexual life quality of patients with…
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Assisted Reproductive Technology Outcomes in Women with and without Endometriosis
By Selma Oransay
Endometriosis causes infertility in one-third of patients, while in approximately 25-35% of infertile women, the cause is endometriosis. The primary interest and the question of Moss et al. from the University of Queensland, Brisbane, Australia was "the differences in the…
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Routine preoperative ureteral stent and complications in Deep Infiltrating Endometriosis
By Bahar Yuksel
Deep infiltrative endometriosis is a devastating disease that includes both anterior and posterior compartments, and ureteral infiltration with endometriotic nodules affects 1 to 6% of all deep infiltrative endometriosis patients. In the study conducted by Giulia Borghese et al., the…
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Impact of surgery before IVF in infertile women with endometrioma
By Hale Goksever Celik
Among the women with endometriosis, 30 to 50% are estimated to have infertility. On the contrary, among women who present with infertility, 25 to 50% are estimated to also have endometriosis. Several mechanisms have been proposed to explain the association…
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Adenomyosis in adolescents
By Nasuhi Engin Aydin
Dr. Exacoustos and colleagues from two tertiary referral university hospitals in Italy published their results on adenomyosis in adolescent patients in a recent issue of “The Journal of Minimally Invasive Gynecology”. Adenomyosis is the presence of endometrial glands and stroma…
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Best practice: How to reduce intraoperative bleeding?
By Selma Oransay
Although laparoscopic hysterectomy is a popular and common approach for removing benign uterine lesions, some technical steps especially concerning uterine artery closure depend on the surgeon's preference. Uterine artery ligation may be performed either at the uterus level, which is common…
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Catching endometriosis from the front line: educating general practitioners
By Bahar Yuksel
It should be repetitively pronounced that "endometriosis is very common and it is very important to diagnose it as soon as possible before it causes lifelong damage to women’s lives". The sooner the better concerning the diagnosis, and this is…
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A rare complication of endometriosis
By Selma Oransay
Morales et al. from the Monterrey School of Medicine, Mexico, reported a case of bowel intussusception in a woman with severe endometriosis to draw attention to this very rare endometriosis complication. The case is a 27 years old young female…
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Depression and Anxiety Common in Women with Endo
By Özge Özkaya
Symptoms of depression and anxiety are frequent among women with endometriosis and are related to chronic pain, confirms a review of the literature and meta-analysis published in the Journal of Women's Health. According to the study authors, correlating factors should…
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Technical Facts for the Prevention of Complications After Deep Endometriosis Surgery
By Özge Özkaya
There are no differences in the risk of rectovaginal fistula in women with rectovaginal endometriosis who were managed by a liberal or restrictive policy of preventive stoma according to a study by French researchers published in the Journal of Minimally…
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How to measure the length of recto-sigmoid deep endometriosis reliably?
By Eylül GÜN
An in-depth assessment is needed when rectosigmoid deep endometriosis is decided to be treated surgically. Surgery carries a lot of risks and it is not always easy to decide which procedure the patient would benefit the most from. Patient-oriented surgical…
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Not just the pain stops but also the bowel function improves after DIE surgery
By Bahar Yuksel
Bowel endometriosis and the techniques to operate it have always been a challenge. The study conducted by Beraldo et al., from Brazil, highlighted the results of an effective nerve-sparing bowel surgery on endometriosis lesions and its long-term effects on patients. The…
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Is the presence of nerve fibers in the endometrium associated with endometriosis?
By Eylül GÜN
Endometriosis is a common disease in reproductive women and diagnostic imaging have a limited role in its diagnosis. The gold standard diagnostic method remains to be the histopathological examination of the tissue obtained via laparoscopy. One of its most common…
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Impact of adenomyosis on sexual life
By Selma Oransay
Considering the similar etiopathogenesis and pain symptoms between adenomyosis and deep infiltrating endometriosis, Alcalde et al. from the Department of Gynecology, University of Barcelona, Spain, aimed to call attention to the presence of potential sexual dysfunction not only in patients with deep…
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Medical Examination Reduces Anxiety in Women With Suspected Endometriosis
By Özge Özkaya
Anxiety levels go down after medical examination in women with suspected endometriosis, found a study by Italian researchers that was published in the Journal of Psychosomatic Research. This was especially pronounced in women who had higher baseline distress and who…
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Does exercise have an effect on pain perception in women with endometriosis?
By Hale Goksever Celik
Endometriosis is an inflammatory disease causing pain symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain, and also infertility. Several medical and surgical treatment options have been developed to improve quality of life of these women. Despite extensive research, the optimal…
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MicroRNAs in the pathogenesis of endometriosis and infertility
By Eylül GÜN
The gold standard in the diagnosis of endometriosis is laparoscopy and histopathological diagnosis, however search for a non-invasive method has been ongoing. Some biomarkers such as Cancer Antigen 125 have been thought to be useful, but because of their low…
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Postoperative ovulation induction in infertile women with minimal to mild endometriosis
By Hale Goksever Celik
Infertility is an important problem that is encountered in 30-50% of women with endometriosis. Several etiopathogenetic mechanisms for the development of reproductive problems in women with endometriosis have been proposed including abnormal peritoneal microenvironment, ovarian dysfunction and/or decreased oocyte quality,…
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Women reject using hormonal drugs for endometriosis, an accelerating need for nonhormonal medications
By Bahar Yuksel
Although the pathophysiology of endometriosis is poorly understood, endocrine drugs are widely used for reducing inflammation and patients’ symptoms. Burla and colleagues aimed to evaluate the patients’ thoughts and expectations about the endocrine drugs which are used in the treatment…
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The Surgical Management of Endometriosis of the Ureter and Bladder
By Özge Özkaya
Laparoscopic surgery is feasible and safe to manage endometriosis of the ureter and bladder, according to a new study published in the Journal of Minimally Invasive Gynecology. According to the authors of the study, ureteral resection is more strongly associated…
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The higher the cyst fluid iron concentration, the more severe the pain symptom for endometrioma
By Hale Goksever Celik
Endometriosis usually is encountered in three different forms: superficial peritoneal endometriosis, ovarian cysts (endometrioma) and deep infiltrating endometriosis. Endometrioma can be identified as cystic lesions consisting of dark brown endometrial fluid and are sometimes referred to as "chocolate cysts." The presence…
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Endometriosis scar disruption may lead to "spontaneous hemorrhage in pregnancy" and can be life-threatening.
By Selma Oransay
Kollikonda et al from Cleveland Clinic Women's Health Institute, Cleveland, Ohio, US penned a case report about their hemoperitoneum experience during labor, which was recently published in the "Journal of Obstetrics and Gyneaecology Canada". The aim is to warn obstetricians…
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How to predict the complications after laparoscopic bowel resection in women with endometriosis
By Hale Goksever Celik
The endometriotic lesions infiltrating the bowel wall more than 5 mm. are called "deep infiltrating endometriosis". The patients having bowel involvement may have constipation, diarrhea, tenesmus, or rectal bleeding. Surgical management is the main treatment modality to provide benefits on pain, infertility,…
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Evaluation of preoperative risk factors of ureteral endometriosis
By Selma Oransay
Endometriosis affects the urinary tract in 1% to 5.5% of the patients, and among them, bladder involvement is 70-85%, while ureteral involvement alone is 9% to 23%. Ureteral endometriosis is most commonly unilateral, especially on the left side, usually affecting…
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Promising potential research topic: diagnostic biomarkers for endometriosis
By Nasuhi Engin Aydin
Dr. Toczek and collegues from the Department of Gynecology, Obstetrics and Oncological Gynecology of Medical University of Silesia in Katowice, Poland, have published a review paper on possible diagnostic aid of cytokines in endometriosis. This review appears in May issue…
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Which is the best for ovarian reserve preservation? Hemostatic agent or coagulation?
By Bahar Yuksel
The way of ovarian parenchymal bed hemostasis following ovarian cystectomy is crucial for ovarian reserve protection, and discussions about different techniques on this issue are ongoing. Multiport laparoscopic surgery is the standard method for ovarian surgeries, but laparoendoscopic single-site cystectomy became…
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The endless burden: sexual dysfunction and endometriosis
By Bahar Yuksel
The relationship between endometriosis and sexual health in women is one of the hottest topics in obstetrics and gynecology practice. There are some previous reports that investigated the effect of endometriosis on the loss of libido, arousal disorder, orgasmic dysfunction,…
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What Happens to Endometriosis Patients After Endometriosis Surgery?
By Özge Özkaya
Although few patients with endometriosis who undergo a hysterectomy need repeat surgery, up to 25% of them need minor surgery. Around 20% of patients who undergo conservative surgery with ovarian preservation require additional endometriosis surgery. Up to one in three…
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Endometriosis in intestine! Segmental resection or linear nodulectomy?
By Bahar Yuksel
Intestinal involvement of endometriosis is common, and the incidence was defined between 45-56%. Previous studies investigating the role of surgery in the management of intestinal endometriosis reported improvement of life quality in up to 95% of cases following surgery. However,…
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Optimal management of infertility in endometriosis patients
By Hale Goksever Celik
Pelvic pain and infertility are the main symptoms of endometriosis patients. Although the pathophysiological mechanism for infertility is not clearly understood, there are several theories explaining decreased fertility potential in women with endometriosis. Ata and Telek, from Koc and Istanbul Universities…
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Endometriosis and susceptibility to COVID-19
By Nasuhi Engin Aydin
Dr. Moazzami and associates from Pars Advanced and Minimally Invasive Medical Manners Research Center, Tehran, Iran have published their results on COVID-19 in endometriosis patients in the medical journal named "BMC’s Women’s Health". COVID-19 is still an emerging critical global health problem…
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Targeting Endometriosis From a Different Angle
By Özge Özkaya
Dopamine agonists could help reduce the size of endometriosis lesions and minimize pain, while maintaining ovulation, according to a new study published in the scientific journal Human Reproduction. This constitutes a completely different approach in targeting endometriosis according to Dr.…
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Postoperative treatment and pregnancy points to decreased recurrence risk for ovarian endometriosis
By Hale Goksever Celik
Endometriosis is a disease most frequently diagnosed in women of reproductive age and negatively affects the quality of life. The most common localization for endometriosis is ovaries with a prevalence of 17-44%. Laparoscopic ovarian cystectomy performed as excision or ablation…
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Endometriosis, ART, fertility preservation
By Selma Oransay
This review entitled "The impact of endometriosis on the outcome of assisted reproductive techniques: role of fertility preservation" was written by Necula et al. from Gynecology and Obstetrics Unit, Biel, Switzerland, and recently published in the journal "Hormone, Molecular Biology and Clinical…
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Controlled use of bipolar cauterization as an alternative to endometrioma cystectomy
By Hale Goksever Celik
The main symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Ablation or coagulation of the cyst wall following laparoscopic drainage of endometrioma may be an alternative treatment for patients with pregnancy intention. Carbon dioxide, laser, and plasma energy…
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Perineal Endometriosis, How Soon Does it Return After Surgery?
By Özge Özkaya
The higher the body mass index (BMI) of a woman during delivery and within one month after delivery, the quicker the symptoms of perineal endometriosis return. This is according to a recent study that appeared in the World Journal of…
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By Dr. Youngran ParkThe influence of endometrioma and surgery on ovarian reserve
By Dr. Youngran Park
Women with endometriosis and endometrioma, often have subfertility. These patients present considerable problems for the evaluation of ovarian reserve. One of the well-known ovarian reserve biomarkers is anti-Müllerian hormone (AMH) levels. So far, it was known that the reduction of…
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The effects of endometriosis on life satisfaction.
By Bahar Yuksel
Endometriosis is well-known for its debilitating effects on women suffering from it. In the review conducted by Masoumeh Namazi et al, the authors have collected studies searching for the wellbeing of women with endometriosis. They have analyzed 46 studies that…
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Endometriosis and Sexual Satisfaction
By Özge Özkaya
Endometriosis affects the ability to have an orgasm during sexual intercourse, according to a study published in The Journal of Sexual Medicine. However, the disease does not have an effect on reaching orgasm via masturbation or sexual activities with a…
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Environmental to occupational exposure, and possible risk factors for endometriosis.
By Selma Oransay
Many objects in daily use are made of plasticizing agents. Studies suggest that chronic exposure to these agents are toxic to reproductive organs and cause metabolic disorders. For example, diethyl phthalate is still in use in cosmetic products. Caporossi et…
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DNA damage response in eutopic endometria of endometriosis patients
By Dr. Youngran Park
The DNA damage response (DDR) is a network of cellular pathways that sense, signal, and repair the lesions occurring in DNA. Surveillance proteins that monitor DNA integrity activate the DNA repair pathways in response to DNA damage and try to prevent the generation of potentially deleterious mutations. Endometriosis is an estrogen-dependent…
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Impaired fertility potential in endometriosis patients
By Hale Goksever Celik
Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis and sperm movements. Garcia-Fernandez and García-Velasco, from Edinburgh, UK and Madrid, Spain, published a mini-review titled “Endometriosis and Reproduction: What We Have…
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The improvement of fertility rate and symptoms of superficial endometriosis following laparoscopic peritoneal stripping
By Selma Oransay
Pain, in the form of diverse entities, including dyspareunia, dysuria, dyschezia, is the main symptom of endometriosis patients. The severity of pain is independent of the extent and the location of the disease, and generally causes a negative impact on…
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A comparison of symptomatology and histopathologic features in surgically resected colorectal endometriosis
By Nasuhi Engin Aydin
Dr. Tschan and associates from Feldrich Academic Teaching Hospital, Austria published their retrospective research on patients requiring colorectal surgical resection for endometriosis in European Journal of Medical Research. Bowel endometriosis requiring colorectal surgical resection causes important morbidity. The rectum and…
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By Ellen TumimbangOxidative stress, reactive products, detoxification, endometriosis and pain
By Ellen Tumimbang
Oxidative stress is one factor known to be involved in the pathogenesis, progression, and establishment of endometriosis in women. During oxidative stress, excess reactive oxygen species as a secondary by-product of lipid peroxidation and reactive aldehyde including 4- hydroxynonenal…
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Live Birth Rate in Women Who Underwent Fresh Embryo Transfer Using Freshly Retrieved Donor Oocytes
By Hale Goksever Celik
One of the important clinical findings in women with endometriosis is reproductive problems. Infertility can be encountered in up to 50% of women with endometriosis and up to 50% of women with infertility can be diagnosed with endometriosis. Several pathophysiologic…
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High-dose progestin intake and sexual functions in endometriosis patients
By Selma Oransay
Dr. Oppenheimer et al. from the Department of Reproductive Medicine and Fertility Preservation of Antoine Beclere University Hospital, Clamart, France, recently published this bi-center observational prospective study in "Acta Obstetrica et Gynecologica Scandinavica". The study was designed to put forth…
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Endometriosis, Fatigue and Productivity
By Ellen Tumimbang
Fatigue is one of the prominent and distressing symptoms of endometriosis-associated with insomnia, depression, pain, occupational stress, and reduced health-related quality of life. Endometriosis-related fatigue causes significant impairments in workplace productivity and daily activities of women with endometriosis. Loss of…
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Deep endometriosis treatment options based on the patient's decision
By Selma Oransay
Deep endometriosis, defined as endometriotic lesions penetrating deeper than 5 mm into the peritoneum comprise approximately 20% of all endometriosis cases. This invasive disease causes a significant reduction in the quality of life, social participation, and sexual health of affected…
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Exploring the Role of Neuropathy in Re-Operative Endometriosis - Marc Possover, MD, PhD
By Özge Özkaya
Prof. Possover starts his presentation by summarizing the possible cause of pelvic neuropathy following endometriosis surgery. Pelvic neuropathy is the damage or dysfunction of the pelvic nerve. Prof. Possover explained that this could either be due to incomplete surgery, disease…
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Operative techniques for Deep Endometriosis Surgery - Shaheen Khazali, MD
By Özge Özkaya
In this presentation, Dr. Shaheen Khazali, an endometriosis surgeon specialized in gastrointestinal and urinary tract endometriosis excision and in neuropelveology, talks about the general principles and some techniques for endometriosis surgery focusing on rectovaginal endometriosis. He also describes the "ten…
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Laparoscopic Approach to Rectus Muscle Endometriosis and Inguinal Endometriosis - Ted Lee, MD
By Selma Oransay
Rectus muscle endometriosis and inguinal endometriosis are two rare types of endometriosis. Operation room videos of several patients with different rectus muscle endometriosis and inguinal endometriosis are shared during the presentation of Dr. Lee to clarify the methods of the…
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Role of Prophylactic Oophorectomy in Endometriosis Patients with Ovarian Cancer History in the family - Farr Nezhat, MD
By Özge Özkaya
Dr. Nezhat starts his presentation by outlining his objectives, which are to review the basics of cancer genetics, give an overview about endometriosis and ovarian cancer, discuss the pathogenesis of malignant transformation of endometriosis, and talk about the clinical implications…
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Implantation failure in endometriosis patients - Jovana Lekovich, MD., PhD.
By Hale Goksever Celik
Endometriosis is one of the leading reasons for infertility due to decreased oocyte/embryo quality, fertilization ability, tubal function, and aberrant endometrial receptivity. Whether this failure is caused by oocyte/embryo or eutopic endometrium is one of the investigated topics in endometriosis…
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In vitro fertilization protocols in endometriosis patients - Pinar Kodaman, MD., PhD.
By Hale Goksever Celik
Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis, and sperm movements. Even though the disease stage and presence of endometrioma is negatively correlated with infertility, it is unpredictable which women…
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Could Cosmetics and Personal Care Products Increase the Risk of Endometriosis?
By Özge Özkaya
The use of cosmetics and personal care products may be increasing the risk of endometriosis according to a study by Spanish researchers that was published in the journal "Environmental Research". This finding suggests that restricting the use of these products may…
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Endometriosis and the sexual relations of the couples
By Selma Oransay
From the viewpoint of endometriotic women, the pain during the penetration is not the only complaint. They also have growing depression and anxiety leading to difficulties with their social and sexual relationship, work, and study. The emotional impact of sub-infertility,…
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By Irem OnurEndometriosis involving the Sacral Plexus and Sciatic Nerve
By Irem Onur
Endometriosis rarely involves the sacral and sciatic nerves. A retrospective analysis led by Rouen University Hospital, France and Aarhus University Hospital, Denmark, published in the Journal of Minimally Invasive Gynecology, has evaluated preoperative complaints, intraoperative findings, surgical procedures, and postoperative…
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Endometrioma size and anti-Müllerian hormone levels
By Hale Goksever Celik
Endometriotic lesions are encountered in different locations in the pelvic cavity, including but not limited to the ovaries, the pouch of Douglas, the ureters, the bladder, and the bowel. Cystic endometriosis lesions located in the ovary are called "endometrioma". Endometriomas have…
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Does hysterectomy bring a total relief in patients with endometriosis?
By Bahar Yuksel
There is a common belief that hysterectomy is the last option to relieve the pain in patients with endometriosis by stopping the production of menstrual material. The study entitled "Impact of hysterectomy on analgesic, psychoactive and neuroactive drug use in…
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Endometriosis and chronic opioid use
By Selma Oransay
The members of the American College of Obstetricians and Gynecologists have declared that gynecologists prescribe opioids after laparoscopic hysterectomy, or for relieving endometriosis pain, although guidelines are not available for when or how to use opioids for the treatment of endometriosis-associated…
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Reduced risk of "small for gestational age baby" following frozen embryo transfer in endometriosis patients
By Hale Goksever Celik
Infertility is encountered frequently in patients with endometriosis. These women could be managed using assisted reproductive technology (ART) including in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) to achieve pregnancy. However, some adverse obstetric and perinatal outcomes are experienced more…
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Comparison of diagnostic accuracy of imaging modalities for the deep infiltrating endometriosis
By Selma Oransay
The treatment of deeply infiltrated endometriosis (DIE) is usually personalized and the potential success for the available therapeutical options is dependent on early and accurate diagnosis. Laparoscopy is the gold standard for the diagnosis of DIE. Other non-invasive diagnostic methods…
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A pilot study for Endometriosis Potential biomarkers
By Ellen Tumimbang
Endometriosis is one of the most common female health disorders typically causing dysmenorrhea, dyspareunia, and pelvic pain, and may contribute to infertility. It is necessary to identify potential molecular biomarkers for diagnosis and regulatory factors behind the disease. The study…
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Magnetic resonance imaging classification for the management of deep pelvic endometriosis
By Irem Onur
A new study published in the journal "Human Reproduction" reported that operating time, hospital stay, and postoperative complications in patients who underwent surgery for deep endometriosis can be predicted by the MRI. This result may be useful for clinicians to…
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Patients' opinion about surgical treatment of endometriosis
By Selma Oransay
Delayed diagnosis and management of endometriosis and chronic pelvic pain is a major problem in gynecologic practice. Alternatively, providers may feel reluctant to perform surgery although they are aware of treatment options and surgical timing. One possible reason for this…
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A new Marker to Detect Endometriosis and Its Severity?
By Özge Özkaya
Macrophage migration inhibitory factor (MIF) could be a novel marker that could help diagnose endometriosis as well as to detect its severity. This is according to a new study by researchers in Egypt, published in the scientific journal "BMC Women’s Health".…
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Segmental bowel resection could be predicted using MRI in patients with rectal endometriosis
By Hale Goksever Celik
The rectum and recto-sigmoid junction are the preferential localisations of bowel endometriosis. The three main surgical approaches are shaving, disc excision, and segmental resection. It is very important to decide the most appropriate surgical method preoperatively and to plan accordingly. …
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Dyspareunia and Endometriosis
By Irem Onur
Women experience severe pain during intercourse related to endometriosis and this has a significant negative impact on the lives of women. This is according to an American study published in the "Journal of Pain Research". The study included 638 endometriosis…
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Assessment of Reproductive Health for Women With Endometriosis
By Özge Özkaya
Researchers in Iran developed a new and reliable patient-generated instrument to measure the reproductive health of women with endometriosis. Health providers as well as researchers can use the questionnaire to better understand the impact of the disease on women’s reproductive health…
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Stem cell and exosome therapy
By Dr. Youngran Park
These days, two experimental methods, stem cell, and exosome therapy are getting more attention. Stem cell therapy has shown promising effects in regenerative medicine, including myocardial infarction, nervous system impairment, retinal damage, and liver diseases. Recent studies showed that stem…
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Depression and anxiety levels in "in vitro fertilization" patients with endometriosis
By Hale Goksever Celik
Endometriosis is a reproductive-aged and estrogen-dependent disease. The most common symptoms of this disease are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility affecting the quality of life in several aspects mainly the psychological domain. In the literature, there are many studies…
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Pain and Quality of Life Following Surgical Treatment for Endometriosis
By Ellen Tumimbang
Currently, laparoscopy is the preferred approach as a surgical treatment of endometriosis. Many studies have shown the effectiveness of laparoscopic surgery to reduce the painful symptoms and improve the quality of life for patients with endometriosis in the short term…
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Time for reassessment : Laparoscopic surgery and bowel endometriosis
By Nasuhi Engin Aydin
Ferrero and associates from medical centers of Verona and Genoa, Italy, made a comprehensive review covering all aspects of the surgical approach to bowel endometriosis, published their results in "Best Practice & Research Clinical Obstetrics and Gynaecology". Bowel endometriosis is the…
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Predictors of voiding dysfunction after surgery for deep endometriosis
By Selma Oransay
While surgery for deep endometriosis provides relief and improves the quality of life in symptomatic patients for whom medical therapy has limited effect, it may also create postoperative lower urinary tract dysfunction. Moreover, postoperative voiding dysfunction could affect the quality…
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Sleep Quality, Lifestyle Factors and Endometriosis
By Hale Goksever Celik
Endometriosis does not only affect the patients by dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. An important issue in these patients, like other chronic diseases, is sleep quality. Youseflu et al., from Iran, published a study entitled “Effects of endometriosis…
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By Timur SeckinFactors affecting the quality of life of women with endometriosis
By Timur Seckin
Results from a new study suggest that the quality of life of women with endometriosis is significantly affected by their confidence to manage pain and their belief in the evolution of their condition. In this study, led by Rees M. et…
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Endometrium and HOXA 10 gene
By Ellen Tumimbang
Homeobox genes are transcription factors containing a conserved DNA sequence that encodes homeodomain which has a helix-loop-helix-turn structure. The homeodomain is responsible for recognizing and binding specific DNA sequences to regulate the expression of target genes. There are at least…
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Deep Endometriosis or Recto-uterine Obliteration Without Endometrioma
By Selma Oransay
The diagnostic help of ultrasound is increasing by its ability to diagnose deep infiltrating and rectouterine pouch obliteration in patients who are suffering from chronic pelvic pain. Clinicians are used to evaluating the rectal and parametrial areas of the endometriotic…
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Antioxidant Enzymes in Endometriosis
By Dr. Youngran Park
Recent attention has been focused on the effect of oxidative stress in the development of endometriosis. Especially, there are several studies regarding glutathione peroxidase (GPX), a major enzyme in removing various reactive oxygen species. In the field of infertility, the…
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The advantages of combined vaginal-laparoscopic approach on voiding dysfunction for rectovaginal endometriosis
By Irem Onur
The patients with rectovaginal endometriotic nodules with extensive vaginal infiltration who are managed combined vaginal-laparoscopic approach have a lower risk of postoperative bladder dysfunction when compared to surgery via laparoscopy alone. This is according to a manuscript published in the…
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By Yu YuInhibiting killer on the move
By Yu Yu
The three main forms of endometriosis are superficial, ovarian, and deep endometriosis. The latter is defined by the presence of endometriotic nodules that are deeper than 5 mm. Deep endometriosis is considered the most aggressive and is associated with severe…
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The impact of laser vaporization on reproductive outcomes in women with endometrioma
By Hale Goksever Celik
Despite extensive research, the optimal method for the management of endometriosis still remains unclear. Excisional surgery is claimed with a more favorable outcome than drainage and ablation regarding the recurrence of disease and symptoms. On the other hand, cyst vaporization…
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Progesterone Receptors and Endometriosis.
By Ellen Tumimbang
Endometriosis is characterized as a chronic and inflammatory disease in which the specific cause has not been completely understood. Nonetheless, altered estrogen signaling and progesterone resistance are the common attributes of endometriosis. Progesterone resistance is partly attributed to a decrease…
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Benefits of Nerve-Sparing Hysterectomy
By Selma Oransay
The retroperitoneal spread of endometriosis or cancer may involve pelvic autonomic nerves situated on the lateral aspects of uterosacral ligaments, vesicouterine ligaments, and medial aspects of parametria. During the conventional open hysterectomy operations, nerve-sparing excision is very difficult, simply because pelvic autonomic nerves…
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Voiding Dysfunction after Colorectal Surgery for Endometriosis
By Timur Seckin
Postoperative voiding dysfunction is a less frequent complication of rectal shaving than that of discoid excision or segmental resection in patients undergoing colorectal surgery for endometriosis, regardless of its definition. This is according to a meta-analysis conducted by researchers from…
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Prevalence, Risk factors and Management of Bowel Fistula after Rectosigmoid Surgery for Deep Endometriosis
By Selma Oransay
Bowel fistula is a severe complication after the colorectal endometriosis surgery, but little is known about its prevalence, and reports on large series are lacking. To discuss specific management on colorectal deep endometriosis, Roman et al. conducted a retrospective study…
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Fallopian tubes and endometriosis
By Selma Oransay
There are multiple theories to explain the pathogenesis of endometriosis, among which the most popular one is Sampson's retrograde menstruation theory. The role of endometrial stem cells/progenitors are widely studied to support the origin of ectopic lesions in recent decades.…
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By Nadire DuruClinical characteristics linked to recurrence of ovarian endometrioma
By Nadire Duru
Endometriosis affects 10-15% of women. Three types of endometriosis are peritoneal, ovarian, and deep infiltrating endometriosis. Ovarian endometriosis is the most common type of endometriosis with a high rate of recurrence. Laparoscopy is the gold standard treatment for endometriosis and…
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A New Treatment Approach for Endometriosis?
By Özge Özkaya
A new approach may be effective at relieving pain associated with endometriosis according to a study published in the PM&R Journal. The new technique may also improve “overall pelvic function, particularly in relation to intercourse, working, and sleeping,” according to the…
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Adolescent endometriosis
By Timur Seckin
A recent article, led by experts from Peking Medical Union College, describes the clinical characteristics and postoperative symptoms of adolescent endometriosis. The authors inform that their report, which is published in the "Journal of Pediatric and Adolescent Gynecology", can provide…
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Hysterectomy as a choise of chronic pelvic pain relief in endometriotic women.
By Selma Oransay
Sandstrom et al. from the Department of Obstetrics and Gynecology of Umea University, Sweden, found a significant and long-lasting reduction in pain symptoms after hysterectomy among women with confirmed endometriosis and recently published their results in "BJOG". The authors performed…
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Cancer-associated mutations and endometriosis
By Ellen Tumimbang
Endometriosis is thought to benign gynecological disease. However, recent studies compiled in this review paper suggest that spontaneous somatic mutations are driven to occur during the cyclic bleeding resulting in endometriosis tissue undergoing repeated tissue injury and repair. Mutations are…
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Local inflammation and follicle development in women with ovarian endometriosis
By Dr. Youngran Park
Endometriosis, a cause of subfertility, is found in almost 50% of infertile women. The elevated levels of cytokines in the follicular fluid of patients with endometriosis might account for the ovulatory dysfunction. Granulosa cells (GCs) play important roles in follicular…
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Anogenital distance and endometriosis
By Timur Seckin
Endometriosis may be associated with exposure of the embryo to chemicals called ‘endocrine disruptors’. Exposure to endocrine disruptors can be estimated by measuring the anogenital distance (i.e. the distance between the clitoris and the anus), using a centimeter ruler with…
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International experts commentary for assisted fertility treatment facilities amidst COVID-19
By Nasuhi Engin Aydin
A multinational and multi-institutional commentary led by Dr. Alviggi from Italy and Dr.Esteves from Brazil has addressed important issues on assisted reproductive technology treatment amid COVID-19 lockdown suggesting remedies in the journal of "Reproductive Biology and Endocrinology" May 2020 issue.…
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Race, socioeconomic status, and health
By Dr. Youngran Park
Racial disparities in health have been long noted in the United States. The differences in socioeconomic status across racial groups are a major contributor to racial disparities in health. However, race reflects multiple dimensions of social inequality. Understanding and effectively…
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Discrepancies between racial/ethnic groups and choice of hysterectomy procedures
By Nasuhi Engin Aydin
Dr. Pollack and associates from Washington University, St.Louis, made multistate research regarding the patient profile in hysterectomies and published their results in the 2019 December issue of "The Journal of Minimally Invasive Gynecology". The most frequently performed nonobstetric surgery in…
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The predictors for sexual dysfunction in infertile women with endometriosis
By Hale Goksever Celik
Endometriosis is a disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. Its incidence ranges up to 10% of reproductive-aged women. The most common symptoms in these women are chronic pelvic pain, dyspareunia, and…
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By Murat OsmanUltrasound diagnosis of endometriosis: One Size Does-Not-Fit-All
By Murat Osman
Deeply infiltrating endometriosis (DIE) is an advanced form of endometriosis that causes significant morbidity to many women. The Pouch of Douglas (POD), otherwise known as the rectouterine space, is the anatomic area between the posterior cervix and anterior rectum. Its…
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Risk Factors Associated with Ureteral Endometriosis
By Özge Özkaya
Patients with severe endometriosis, uterosacral ligament deep involvement with endometriosis lesions of 3 cm in diameter or more, and the presence of previous endometriosis surgery have a significantly higher risk of having ureteral endometriosis. This is according to a study…
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Resveratrol for infertility: A frenemy?
By Selma Oransay
Ovarian aging is defined by an age-specific decline of the functional ovarian reserve. Female ovarian reserve declines progressively with increasing chronological age. Chronic damage by reactive oxygen species results in deterioration and aging through mitochondrial dysfunction, telomere shortening, cohesion dysfunction,…
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Appendiceal endometriosis
By Selma Oransay
Jeong et al. from the Departement of Surgery, Trinity School of Medicine, Saint Vincent, recently published their interesting appendectomy case in "Hong Kong Medical Journal". In their case, endometriosis inside the cavity of the appendix mimicked appendicitis, the patient submitted…
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Maternal body mass index and neonatal outcomes in women with endometriosis
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal-like tissue outside the uterine cavity. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of…
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Hysterolaparoscopy Plus Assisted Reproduction Improves Fertility in Women with Endometriosis
By Özge Özkaya
Hysteroscopy and laparoscopic surgery is an effective and reliable therapeutic procedure, confirmed a study published in the "Journal of Clinical Medicine". The approach is even more effective when combined with assisted reproductive techniques such as artificial insemination and in vitro…
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Transvaginal sonography for predicting the distance between rectosigmoid endometriosis and the anal verge
By Timur Seckin
For optimal surgery, pre-surgical assessment of the distance between rectosigmoid deep endometriosis lesions and the anal verge (Lesion to Anal Verge Distance-LAVD) is recommended by many specialists. A group of researchers from Norway, Austria, and Australia studied the accuracy of…
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Surgical approach to rectovaginal endometriosis.
By Selma Oransay
Recto-vaginal endometriosis incidence is estimated at 3.8%-37% among women with endometriosis and when it exists it's a part of deeply infiltrated endometriosis, thus advance stage endometriosis. Raimondo et al. from the Department of Obstetrics and Gynecology of the University of…
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tRNA-derived fragments in ovarian endometriosis?
By Dr. Youngran Park
Endometriosis is an estrogen-dependent mysterious disorder characterized by the presence of endometrium outside the normal location of the uterus cavity. This disease affects approximately 10% of reproductive-aged women and becomes a major reason for infertility in reproductive-aged women and dysmenorrhea…
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Antioxidants inhibit autophagy in ectopic endometrial cells
By Nadire Duru
Factors involved in the development of ectopic endometrium are not well-known, but several reports demonstrate a potential role for the pathophysiological processes including autophagy. Studies show that autophagy plays a significant role in endometriosis but the key mechanisms underlying the…
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Fertility preservation protocols in women with endometriosis
By Hale Goksever Celik
Infertility is one of the major symptoms in women with endometriosis. Childbearing at a delayed age is preferred by the majority of women recently who consult for the demand for fertility preservation procedures. There are several techniques for fertility preservation…
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Early Life Factors for Endometriosis
By Dr. Youngran Park
Endometriosis affects approximately 10% of reproductive-aged women. Despite the significant impact, the etiology of endometriosis is still unclear. A recent systematic review of 15 studies of adolescents found that overall 65% of girls undergoing laparoscopic investigation were diagnosed with endometriosis.…
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Long-term Pregnancy Results after Surgical Removal of Endometrioma
By Irem Onur
Sun et al., from China, investigated the pregnancy outcomes and the related factors in patients with endometrioma and stage III-IV endometriosis along with a long-term follow-up postoperatively. Their study has recently been published in the journal named "Advances in Therapy".…
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Regulation of Inflammation in Endometriosis
By Dr. Youngran Park
Endometriosis is an estrogen-dependent and multifaceted gynecological condition. Unfortunately, this disease frequently causes chronic and cyclic pelvic pain. Though there are several treatments are available, there is not an actual cure for this disease. Therefore, the development of new therapy…
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Cycle-related gastrointestinal complaints in reproductive age young women
By Timur Seckin
An analysis of 1-year data on 266 patients who presented to the Clinic and Polyclinic for Gynecology and Reproductive Medicine at Jena University Hospital to undergo surgery for endometriosis and its symptoms was performed by Nicolaous K. et al., a…
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The relationship of serum concentrations of neuropilin-1 (NRP-1) and endometriosis
By Irem Onur
Although many serum biomarkers or biomarker panels for endometriosis are evaluated, none of them is exact enough to be used in daily laboratory practice. In a recent study, which has been published in Scandinavian Journal Of Clinical and Laboratory Investigation, Barberic…
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Primary care physicians have a crucial role in the early diagnosis of endometriosis
By Nasuhi Engin Aydin
Dr. Verket and associates from the University of Oslo, Norway, published their cross-sectional anonymous postal questionnaire study in "BMJ open". Diagnosing endometriosis is difficult because dysmenorrhea, dyspareunia, and infertility are also common among other diseases. The most accurate and reliable diagnosis…
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Impact of Genetic Variations in Endometriosis
By Dr. Youngran Park
Endometriosis is an estrogen-dependent disorder. This disease affects approximately 7% to 10% of reproductive-aged women and causes negative impacts on society. The underlying causes are unclear; therefore, the understanding of this disease remains a major clinical challenge. Endometriosis has a…
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Could my Peritoneal Fluid Have a Negative Effect on my Partner’s Sperm?
By Özge Özkaya
The peritoneal fluid of women with endometriosis could negatively affect the quality and functionality of sperm, according to a study by Spanish researchers. This could explain infertility linked to the male partners of women with endometriosis. The knowledge could also…
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The association between endometriosis and ectopic pregnancy
By Hale Goksever Celik
Endometriosis is a chronic inflammatory disease with a broad spectrum of symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain and fertility problems. It has been understood in the light of scientific evidence that endometriosis is also associated with other poor…
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Endometriosis and atherosclerotic cardiovascular disease
By Selma Oransay
Endometriosis and atherosclerotic cardiovascular disease show the same pathologic mechanism in terms of endothelial dysfunction. Tan et al. from the Department of Obstetrics and Gynecology, the University of British Columbia, Vancouver, Canada reviewed the literature aiming to determine whether women…
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A nonhormonal treatment of endometriosis: Dichloroacetate
By Irem Onur
In women with endometriosis, peritoneal mesothelial cells show higher glycolysis, lower mitochondrial respiration, decreased enzymatic activity of pyruvate dehydrogenase and increased production of lactate compared to women without the disease. Transforming growth factorβ1 and lactate are elevated in the peritoneal…
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How to design patient-centered interventions to meet the needs of endometriosis patients
By Selma Oransay
The treatment of endometriosis is not perfect and necessitates the development of patient-oriented care initiatives. On this basis, patient-related transparent information should be the priority for researchers to find out a way for targeted interventions. Steele et al. from Australia and…
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Does the Severity of Endometriosis Increase the Risk of Complications Following Surgery?
By Özge Özkaya
The severity of endometriosis cannot predict the risk of complications after laparoscopy. Instead, the complexity of the surgical procedure itself may increase the risk of complications. This is according to a study published in the journal "Acta Obstetricia et Gynecologica Scandinavica".…
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Surgery and the endometriosis associated-pain: A systematic review
By Selma Oransay
The surgical approach for pelvic pain-related to endometriosis depends on the stage and the type of the endometriotic lesion and ranging from ablation and the excision of the lesions to radical surgery as hysterectomy with removal of ovaries and presacral…
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MRI findings predicting the need for colorectal surgical treatment of deep infiltrating endometriosis
By Irem Onur
LAY SUMMARY: Brusic A. et al., a group of researchers from Australia, conducted a retrospective study to identify the features of deep infiltrating endometriosis on MRI which have an association with colorectal surgical bowel resection. They have recently published their…
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Quality of Endometriosis Healthcare: What Do Patients Feel, What Do Doctors Say?
By Özge Özkaya
Patients and doctors seem to agree that clinical care for women with endometriosis needs improving. This is according to the results of a study published in the Journal of Psychosomatic Obstetrics & Gynecology. Endometriosis is a severe condition where chronic…
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Regret assessment in women under 35 years who underwent hysterectomy
By Hale Goksever Celik
Hysterectomy is the most common gynecological operation in women for the management of benign or malign indications. Leiomyomas, menorrhagia, endometriosis, and pain unresponsive to medical treatment can be accepted as the most common indications for hysterectomy. However, hysterectomy, as the…
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Cloverleaf Sign: A new MRI sign for diagnosing DIE
By Selma Oransay
Magnetic resonance imaging provides accurate information for the staging of deeply infiltrating endometriosis, especially when the patient is virgin, obese or has limited transvaginal examinations due to pelvic pain. In this recently published study in Investive Radiology, Harma et al.…
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How Best to Assess Productivity at Work Among Women with Endometriosis?
By Özge Özkaya
The health-related productivity questionnaire (HRPQ) is a valid tool to evaluate patient-reported productivity at work and at home among women with endometriosis found a study by U.S. researchers. This finding is important because it shows that HRPQ can be used…
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Recurrent endometriosis is a real challenge both for the patients and clinicians
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Current medical and surgical treatment options have several limitations including the side effects, costs, risk of recurrence, effects on conception capability. Recurrence is a…
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Factors affecting risk of ovarian endometriosis malignancy
By Özge Özkaya
Getting married when older, having had ovarian endometriosis for longer, giving birth in a shorter time, and other complications in the uterus that are benign may all increase the risk of ovarian endometriosis malignancy. This is according to a study…
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A rigorous literature review on endometriosis
By Irem Onur
Bulun SE. et al., from Feinberg School of Medicine, Northwestern University, Chicago, conducted a rigorous literature review on endometriosis. This outstanding review by Dr. Bulun et al. addresses the definition, remarkable medical features, clinically useful research findings, prevalence and distribution,…
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Transvaginal Ultrasound of Endometriosis
By Murat Osman
A recent manuscript published by Collins et al. from the Department of Radiology at Penn State Hershey Medical Center aims to review the transvaginal ultrasound (TVUS) evaluation of endometriosis and offer a protocol that is dedicated to the thorough evaluation…
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Endometriosis of the Appendix
By Timur Seckin
Endometriosis of the gastrointestinal tract is infrequent, and it rarely involves the appendix. A group of researchers from the United States of America reported a case of a 50-year-old postmenopausal woman with endometriosis in the vermiform appendix presenting as acute…
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Serum anti-Müllerian hormone levels for predicting spontaneous pregnancy after endometriosis surgery
By Hale Goksever Celik
Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Although there are several medical and surgical therapeutic options, the most effective treatment modality has not yet been elucidated. The main…
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Consquences of endometriosis in menopausal period.
By Selma Oransay
Marie-Scemama et al. from Foch Hospital, Suresnes, France, referred to endometriosis and menopause which is an actual cruising topic and recently published it in the journal named "Hormone Molecular Biology and Clinical Investigation". Endometriosis a well-known estrogen-dependent disease has three…
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Is there any difference between endometriosis patients with or without obliterated cul-de-sac during laparoscopic hysterectomy?
By Hale Goksever Celik
Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. It is diagnosed in 10% to 15% of reproductive-aged women. Women with endometriosis demand therapy for the most common symptoms, which are…
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A new technique for laparoscopic management of ovarian endometriosis.
By Selma Oransay
To cause a minimal hazardous effect on ovarian reserve during laparoscopic surgery of endometriomas is always a great concern for clinicians. Shaltout et al. from Cairo University, Egypt, examined the effect of "Surgicel" on preventing the recurrence of endometriomas and…
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Which surgical approach for bowel endometriosis?
By Irem Onur
A group of researchers from Spain, led by Dr. Alicia Hernández Gutiérrez, conducted a retrospective study to compare postoperative complications and recurrence of three surgical techniques: segmental bowel resection (group I), discoid excision (group II), and rectal nodule shaving (group…
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Yogurt and ice cream consumption during adolescence may reduce endometriosis
By Yu Yu
Dietary factors may affect the development and severity of endometriosis because of estrogen, prostaglandin metabolism, inflammation, or smooth muscle contractility. Studies investigating the relationship between diet and endometriosis have focused on women’s dietary intake during adulthood. For example, the higher…
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Is there an association between endometriosis and sexual activity during menstruation ?
By Nasuhi Engin Aydin
This recent case-control study with 185 women having endometriosis and 370 women as a control group was conducted in Tebriz University, Iran by Dr. Mollazadeh and associates. Contemporarily, retrograde menstruation is a valid theory for disseminating endometrial tissue to the…
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How Long Does it Take to Be Diagnosed with Endometriosis?
By Özge Özkaya
It takes a median of eight years to reach a diagnosis of endometriosis from when the symptoms of the condition first appear confirmed a new British study. Interestingly, it seems that the earlier the symptoms appear, the later the disease…
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Patients preferences for the treatment of endometriosis-associated pain
By Hale Goksever Celik
Endometriosis is defined as the location of endometrial stroma and glands outside the uterine cavity. The most common presenting complaints are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility, most of which relate to the menstrual period. Those women affected…
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Clinical trial for the use of oral lactobacillus on endometriosis pain severity
By Yu Yu
The standard treatment of endometriosis consists of surgery and hormonal based treatment. There is evidence for the efficacy of these types of treatment, although their side effects remain a critical consideration for women. Based on molecular studies, changes in the…
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The accuracy of "lower endoscopic ultrasound" for the preoperative diagnosis of rectosigmoid endometriosis
By Hale Goksever Celik
Endometriosis affects reproductive-aged women most frequently with a prevalence of 5% to 15%. If the endometriotic lesions involve the bowel especially sigmoid colon and rectum, this subtype of endometriosis is named as "bowel" or "rectosigmoid" endometriosis. Rectosigmoid endometriosis is encountered in…
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How to Classify Endometriosis for a better and effective evaluation
By Selma Oransay
Endometriosis affects 10% of women in their reproductive period and causes infertility around 40% of women who have the disease. Peritoneal fluid may be one of the factors to facilitate the spread of endometriosis to ovaries, peritoneum and other deep…
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Which Diagnosis Technique is Better?
By Özge Özkaya
Transvaginal ultrasound provides a more accurate localization of vaginal and recto-vaginal endometriosis compared to magnetic resonance imaging (MRI) according to a study published in the International Journal of Gynecology & Obstetrics. However, MRI has better accuracy in detecting bladder endometriosis…
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Heme impairs macrophage phagocytosis
By Yu Yu
Heme is an iron-containing molecule that carries oxygen in the blood and also serves many essential biological proteins. It is released from ruptured erythrocytes during hemolysis. If not chelated, heme can cause harmful oxidative damage and inflammation. Thus, heme is…
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Infertility in women with endometriosis
By Hale Goksever Celik
Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. The most common presenting complaints are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Despite extensive research, the etiopathogenic mechanism underlying the two has not been fully elucidated. Although human…
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By Demet Candaş GreenMRI or TVS for accurate diagnosis of rectosigmoid endometriosis?
By Demet Candaş Green
Rectosigmoid endometriosis (RE) is seen in about 90% of patients with bowel endometriosis. Rectosigmoid is the region between the rectum and the sigmoid colon, which is a region easily accessed and assessed by two most common noninvasive imaging modalities –…
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Chronic Fatigue Syndrome and Endometriosis: Comorbid Conditions
By Irem Onur
In the study of Dr. Boneva et al., from Atlanta, GA, the United States which has recently been published in the journal Frontiers in Pediatrics evaluated the impact of endometriosis on the health of women with chronic fatigue syndrome (CFS). The authors compared…
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A study about adnexial torsion doubts in patients with endometriosis.
By Selma Oransay
Endometrioma is the presence of endometriosis cysts in the ovary, and is one of the most common forms of endometriosis, with unknown pathophysiology. Adnexal torsion results in twisting ovarian tissues resulting in a decreased blood flow. The causes for adnexal torsion due…
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The predictors for the coexistence of uterine leiomyomas and endometriosis
By Hale Goksever Celik
Uterine leiomyomas are the most common gynecological benign tumors affecting 20-25% of reproductive-aged women. Abnormal bleeding, pelvic pain, pelvic pressure, and infertility are major symptoms of these tumors. Endometriosis is another gynecological disease encountered in 10-15% of reproductive-aged women. The…
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Seven Hormonal Biomarkers for Diagnosing Endometriosis
By Dr. Youngran Park
Endometriosis is an inflammatory condition characterized by implantation and invasive growth of endometrial tissue outside the uterine cavity. Although it is benign, endometriosis has cancer-like features, a mutation profile similar to that of ovarian cancer, and increased ovarian cancer risk.…
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Baby Years and the Risk of Endometriosis
By Özge Özkaya
Early-life factors such as whether a baby was breastfed, have had vaginal bleeding at birth, or whether or not their father was a smoker may be associated with her risk of developing endometriosis in later life. This is according to…
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Another Genetic Polymorphism That May Increase Risk of Endo
By Özge Özkaya
A single letter change in the Epidermal Growth Factor Receptor (EGFR) gene may significantly increase the risk of endometriosis. This is according to a study conducted among women in Southwest China and published in the journal Medicine. Identifying genetic risk…
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Searching new biomarkers for endometriosis
By Selma Oransay
This recent article published in Advances in Clinical Chemistry, is an overall summary of characteristics, physiopathological theories, diagnostic approaches and variety of biomarkers to diagnose endometriosis and penned by Coutinho et al. from Universidade Federal de Juiz de Fora, Belo Horizonte,…
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Non‑invasive biomarkers for endometriosis diagnosis
By Hale Goksever Celik
Endometriosis is a disease of women in reproductive age and its incidence varies between 5-10%. Since the diagnosis is based on the histological confirmation, there is an average of 7 to 11 years of delays in the diagnosis. Promising non-invasive…
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Antibiotic therapy for endometriosis
By Yu Yu
Current treatments for endometriosis are surgery and hormone therapy; however, these approaches may have significant side effects and do not prevent a recurrence. Therefore, alternative treatment modalities for endometriosis is needed. Recently, the idea that endometriosis may be influenced by…
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The postoperative functional outcomes of deep infiltrating endometriosis
By Hale Goksever Celik
Rectosigmoid endometriosis is defined as the infiltration of the bowel wall with the endometrial-like glands and stroma, reaching at least the muscular layer. The most commonly involved sites are the rectum and sigmoid colon. For the management of deep infiltrating…
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Bladder Endometriosis
By Demet Candaş Green
Bladder endometriosis is rare – about 1-2% of women with endometriosis may have endometrial lesions in their urinary tract. Diagnosis of bladder endometriosis is difficult because of its nonspecific symptoms such as frequent urination, pelvic pain, and burning sensation when…
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Antimullerian Hormone, endometrioma and ovarian reserve
By Selma Oransay
Younis et al. from Baruch-Padeh Medical Center, Poriya, Israel, designed a review study on ovarian reserve alterations before and after endometrioma surgery that recently documented in "Human Reproduction Update". The authors examined the electronic databases of articles published between January…
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Can early-life exposures affect endometriosis development later in life?
By Demet Candaş Green
Endometriosis is a complex disease with possible multifactor contributors. So far, inflammatory, immunogenic, genetic, and environmental factors have all been associated with endometriosis. In addition, it is possible that different types of endometriosis lesions – peritoneal, ovarian, and deep infiltrating…
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Choosing the Right Technique for Deep Colorectal Endometriosis
By Dr. Youngran Park
Endometriosis is a benign gynecologic condition, histologically defined by the presence of ectopic endometrium outside the endometrial cavity. Three clinical presentations of endometriosis have been described and could coexist in the pelvis: peritoneal endometriosis, ovarian endometriosis, and deep infiltrating endometriosis.…
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Ovarian stimulation regimes: Concerns on progression or recurrence of endometriosis
By Selma Oransay
Somigliana et al., from the University of Milan, Italy, performed a literature review to predict the endometriosis-enhancing effect of ART regimes on infertile women and reported their results in Reproductive Biomedicine Online. Their points of interest were increasing dysmenorrhea, dyspareunia, non-menstrual pain and…
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Preoperative factors to predict unresponsiveness in women undergoing endometriosis surgery
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Despite extensive research, the optimal management of endometriosis still remains unclear. Several treatment options include analgesic medication, hormonal treatments, and surgical intervention. There is…
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Breast cancer incidence in women with endometriosis
By Yu Yu
The relationship between endometriosis and breast cancer remains unclear. Some studies have shown an increased risk of breast cancer among women with endometriosis, while others suggested no change in the risk of breast cancer. Previously, the authors have found that…
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Impact of Endometriosis-Related Adhesions on Quality of Life among Infertile Women
By Dr. Youngran Park
Endometriosis is considered the most common cause of pelvic adhesions in women. It is considered one of the main underlying causes of the development of adhesions. Adhesions are bands of connective tissue, which connect two different tissues that are normally…
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Gal-3 can be a pharmacological target in endometriosis treatment
By Demet Candaş Green
Galectins are known to play a significant role in angiogenesis, which is a key event contributing to the development of many disease conditions, one of which is endometriosis. Past studies, upon examining several human endometriotic lesions, showed that Galectin-3 (Gal-3)…
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Factors Affecting Women’s Choices to Enter Clinical Trials
By Özge Özkaya
Women were strongly influenced by their previous experiences and personal circumstances when deciding to take part in a clinical trial. This is based on the findings of a study published in the journal Pilot and Feasibility Studies that explored the…
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Endometrioma, Fertility, and Assisted Reproduction
By Dr. Youngran Park
Endometriosis can negatively impact a woman’s health and quality of life. Surgery has been considered the primary treatment to overcome infertility in cases of ovarian endometrioma. Patients struggling with endometriosis often pursue assisted reproductive technologies (ART) due to fertility issues.…
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Extra-ovarian malignancies risk among women with endometriosis
By Yu Yu
For some time, an association between endometriosis and subsequent cancer risk have been reported. In particular, scientific evidence has shown that endometriosis is linked with risk of certain ovarian cancer subtypes known as clear cell and endometrioid. Since endometriosis is…
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Assistive Reproduction a Suitable Option for the Treatment of Endometriosis-Associated Infertility
By Özge Özkaya
Assistive reproductive techniques do not lead to a worsening in quality of life and only cause a slight worsening of pelvic pain, according to a study published in the scientific journal Acta Obstetricia et Gynecologica Scandinavica. This is the case…
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Bowel endometriosis: What you need to know
By Demet Candaş Green
When the endometrial tissue infiltrates the intestinal walls and reaches inside the intestines, this condition is called "bowel endometriosis". It is estimated that between 3.8% and 37% of women with endometriosis are affected by bowel endometriosis. The endometriosis lesions infiltrating…
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Can we prevent the progression of endometriosis?
By Selma Oransay
Torres-Reveron et al. from the University of Texas, USA, planned this prospective laboratory research on female rats to assay the reduce on the progression of endometriosis and recently published the results in PloS One. At first, endometriosis was induced in female rats…
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Endometriosis and female pelvic pain in all aspects
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence of the disease ranges between 6-10% in reproductive-aged women. However, endometriosis is more frequently encountered in women with chronic pelvic pain and…
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Somatic mutations in iatrogenic endometriosis.
By Selma Oransay
Lac and al., from the Department of Molecular Oncology in BC Cancer Research Center, Vancouver, Canada, planned a retrospective and multinational research to investigate the prevalence of somatic cancer-driver mutations in incisional endometriosis and recently published in the "Journal of Human Reproduction". Their…
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Mistletoe as a Potential Candidate for Endometriosis Treatment
By Dr. Youngran Park
Endometriosis, one of the common benign gynecologic disorders, is defined as the ectopic presence of endometrial cells outside of the uterine cavity. Although the underlying mechanisms are not fully understood, the most accepted hypothesis is that endometrial cells pass through…
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Surgical techniques for rectosigmoid endometriosis, and functional outcomes
By Hale Goksever Celik
Rectosigmoid endometriosis is defined as the infiltration of bowel wall with the endometrial-like glands and stroma, reaching at least the muscular layer. Rectosigmoid endometriosis is encountered in approximately 8-12% of patients with a diagnosis of endometriosis. The most commonly involved…
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Conservative Surgery May Be Sufficient to Halt the Development of Deep Endometriosis
By Özge Özkaya
Deep endometriosis develops as a result of collective cell migration and nerve recruitment from surrounding organs, suggests a study published in the scientific journal Fertility and Sterility. Collective cell migration is the biological process whereby a group of cells moves…
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Factors related to delay in endometriosis diagnosis
By Nasuhi Engin Aydin
Dr. Moniek van der Zanden, a gynecologist from Netherlands has recently made a nationwide survey on the impact of key recommendations of the European Society of Human Reproduction and Embryology (ESHRE) guidelines on endometriosis and aimed to assess factors influencing diagnostic delay of…
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By Serdar BalciDoes the presence of endometriosis increase the risk of gynecologic malignancies?
By Serdar Balci
Endometriosis shares common risk factors with endometrial carcinoma and ovarian carcinomas such as obesity, type 2 diabetes, hyperestrogenism, and reproductive characteristics. Endometriosis is also known to be a risk factor for gynecologic malignant tumors. In this study, Li et.al. have…
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Pelvic pain, congenital genital tract anomalies and endometriosis
By Hale Goksever Celik
Any failure during development and differentiation of female genital tract results in congenital tract anomalies. The origin of the hymen is the union of the caudal portion of the paramesonephric ducts and the urogenital sinus. It functions as a mechanical…
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Further Results From the FEELING Study Published
By Özge Özkaya
Some women are more likely to develop deep infiltrating endometriosis according to the further analysis of the results of the FEELING study. These are women who: are married, are older, have siblings, have had a prior pregnancy, or for whom…
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Immune dysregulation in endometriosis
By Yu Yu
The connection between endometriosis and the immune system has long been proposed. However, to date, there is no real consensus on whether immune adaptations actually facilitate endometriotric lesion progression or they are a consequence of endometriosis re-occurrence. Thus, this article…
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Are women with histologically confirmed endometriosis satisfied with their medical support?
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The most common symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, dyschesia, dysuria, musculoskeletal pain, fatigue and infertility, all of which affect the quality of…
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Not True That Women With Endometriosis Can’t Conceive
By Özge Özkaya
The common assertion that women with endometriosis are unlikely to conceive is countered by a new study published in The European Journal of Contraception & Reproductive Health Care. This finding supports the need for healthcare and information to address all…
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The pain and its severity in deeply infiltrating endometriosis patients
By Selma Oransay
Liang et al. from the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Sun Yat-sen University, China, recently published an interesting paper in the Journal of Pain Research, a prospective study to reveal the relationship between neurogenesis and other potential…
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Any adjustable risk factor for Endometriosis?
By Irem Onur
Endometriosis is believed to be estrogen and progesterone-dependent. Lifestyle factors such as alcohol/caffeine intake, smoking, and physical activity influence estrogen levels in the body and, therefore, may impact the development of endometriosis. In the study of Hemmert et al. which…
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Is Physical Exercise Effective in Endometriosis?
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial tissue outside the uterine cavity. Dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility are mostly encountered symptoms of endometriosis. Although there are several theories explaining the pathogenesis of endometriosis, the exact pathogenesis still has…
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Four cases of endometrioid borderline ovarian tumour: case reports and literature review
By Nasuhi Engin Aydin
Physicians from Kyoto University Graduate School of Medicine, Kyoto, Japan, report four cases of ovarian EBTs and a review literature in a recently published manuscript at British Medical Journal, case reports. Endometrioid borderline tumors (EBTs) of the ovary are uncommon…
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Does deep infiltrating endometriosis affect sexual activity?
By Dr. Youngran Park
Endometriosis is one of the most common gynecological diseases in women of reproductive age, and pelvic pain and infertility are the most frequent complications. There are three different type of endometriosis lesions; superficial lesions, deep lesions, and ovarian cysts. In…
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Three dimensional sono-vaginography to diagnose rectovaginal endometriosis
By Hale Goksever Celik
Deep infiltrating endometriosis is defined as the localization of ectopic endometrial tissue penetrating more than 5 mm into the affected pelvic organs. Rectovaginal endometriosis is the most severe form of deep infiltrating endometriosis in which ectopic endometrial tissue infiltrating rectum…
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Will Getting Pregnant Make My Pain Go Away?
By Özge Özkaya
Pregnancy can relieve the symptoms of endometriosis, according to a new study published in the European Journal of Obstetrics & Gynecology and Reproductive Biology. However, for most women, the pain usually returns like in the case of hormonal therapy. This…
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Non-assisted reproductive technology treatment: Is it effective in infertile patients with advanced endometriosis?
By Hale Goksever Celik
The marriage and childbearing ages delay due to the life-style changes in developed countries. As a result, advanced age becomes a major concern in infertility treatments which consist of non-ART and ART modalities. Non-ART treatments include mild ovarian stimulation together…
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PROPOFOL: a new combat for endometriosis?
By Selma Oransay
Feng et al, from the Department of Gynecology Weifang Medical University Hospital, Shandong, China, recently published their prospective experimental research in the journal Experimental and Therapeutic Medicine. Propofol, a rapid and short-term anesthetic substance, recently has been shown to prevent cancer through inhibiting…
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Will I Have Complications After Endometriosis Surgery?
By Özge Özkaya
The rate of complications after surgery to treat deep infiltrating endometriosis is low, confirmed a study by researchers in Germany. It is important to know whether major or minor complications following surgery are likely to develop and what the outcome…
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Cosmetics and some household products could be responsible for worsening endometriosis.
By Selma Oransay
A controlled clinical study recently published in the Journal of Human Reproductive Sciences, composed by Nazir et al. from the University of Health Sciences, Lahore, Pakistan. The study compared the blood diethyl hexyl phthalate (DEHP) levels of fifty infertile women laparoscopically diagnosed…
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Transvaginal ultrasound for "rectosigmoid endometriosis" diagnosis: Is bowel preparation necessary?
By Hale Goksever Celik
Rectosigmoid endometriosis is a severe form of deep endometriosis. Women having rectosigmoid endometriosis present with pain and several intestinal complains such as constipation, diarrhea, intestinal cramping, abdominal bloating, feeling of incomplete evacuation, the passage of mucus and rectal bleeding during…
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Reduced pain and increased fertiliy rates after surgery for colorectal endometriosis
By Selma Oransay
This prospective cohort study which recently published in AOGS by Hudelist et al. from Oslo University, Norway is about their one hundred thirty-four laparoscopic operations of DIE cases performed between 2011 and 2016, in a tertiary center in Oslo. The…
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IVF Is the Best Option to Become Pregnant for Women with Severe Endometriosis, or Is It Not?
By Özge Özkaya
Treating rectal endometriosis with surgery seems to increase the chance of a woman conceiving, with most pregnancies occurring naturally. This is according to a study published in the medical journal Human Reproduction. The optimal treatment for women with severe endometriosis…
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How to evaluate ureteral endometriosis : A review of the literature
By Selma Oransay
In this recently published review of the literature, Barra et al. from Genova, Italy intend to provide a useful tool to guide physicians in the management of deep infiltrating endometriosis. Authors elected 67 abstracts from Pubmed and Medline in accordance with PRISMA…
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Endometriosis in adolescents
By Irem Onur
Dr. Mama S. T. from Cooper University Hospital, Camden, New Jersey, USA, recently has published his review on advances in the management of endometriosis in the adolescent in the journal “Current Opinion Obstetrics and Gynecology”. In adolescence, there is a…
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A Better Way to Diagnose Endometriosis?
By Özge Özkaya
Three proteins found in the blood and endometrial tissues could be used to determine the stage of endometriosis and the severity of painful periods according to a study published in the journal Current Medical Science. Evaluating the levels of these…
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Should I Have Surgery Before Trying to Conceive?
By Özge Özkaya
The presence of rectouterine nodules is associated with a lower chance of becoming pregnant with in vitro fertilization (IVF), according to a study published in the Journal of Gynecology Obstetrics and Human Reproduction. This finding is important as it can…
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By Deniz KocasQuestionnaire based evaluation of sexual life after laparoscopic surgery for endometriosis
By Deniz Kocas
Researchers from Denmark note that laparoscopic surgery is being increasingly used for the treatment of endometriosis due to its safety and effectiveness. However, treatment success is often evaluated through follow-up on the experience of pain, leaving other important aspects of…
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Complementary treatments for endometriosis symptoms: acupuncture, exercise, electrotherapy, or yoga?
By Yu Yu
Endometriosis is associated with debilitating symptoms in some women including dysmenorrhea, chronic pelvic pain, deep dyspareunia, dyschezia, and dysuria. There are a few therapeutic options to treat these symptoms; however, only a few studies have considered treating the pain symptoms…
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The diagnostic value of “sliding sign” and direct visualization of the bowel in rectal/rectosigmoid deep endometriosis
By Hale Goksever Celik
Deep endometriosis is the presence of endometrial subperitoneal implants of ≥5 mm localized in the rectum/rectosigmoid bowel, uterosacral ligaments, rectovaginal septum, vagina and/or bladder. The most common diagnostic screening methods are the transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI)…
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Comparing opioid and nonopioid therapy for chronic pain
By Deniz Kocas
Over the last few decades, North-America and Europe show continued increase in prescription rates of opioids. Evidence shows significant pain reduction with opioids in the short term compared to placebo, however whether opioids are superior to non-opioids even in the…
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Fluorescence Guided Surgery: a New Technique to Treat Deep Infiltrating Endometriosis
By Özge Özkaya
Fluorescence-guided surgery could help differentiate recto-vaginal deep infiltrating endometriosis nodules (RVDIEN) from healthy rectal tissue and remove them successfully without perforating the rectum, according to a study published in the scientific journal Surgical Innovation. The method could offer a better,…
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By Kasthuri NairAdrenomedullin: The Pervasive Peptide
By Kasthuri Nair
Dr. Aboulghar, from the Cairo University, recently penned an article titled “Role of adrenomedullin in reproduction and endometriosis” that was published in Fertility and Sterility. This article looks at the function of Adrenomedullin (AM) in pregnancy and endometriosis and it…
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Health-related quality of life in women with Endometriosis and Rheumatoid Arthritis
By Murat Osman
Endometriosis is a chronic inflammatory disease that is defined by the presence of ectopic endometrial tissue outside of the uterus. Unfortunately, endometriosis continues to be a leading cause of chronic pelvic pain and long-term morbidity in women of reproductive age.…
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Thoracic Endometriosis Syndrome (TES): Diagnosis by cytology of pleural effusion
By Nasuhi Engin Aydin
Parikshaa Gupta and colleagues from Chandigarh, India report a case of thoracic endometriosis diagnosed primarily by pleural fluid cytology in a most recent article at Cytopathology. A 33-year-old female presented with a long history of recurrent bouts of chest pain…
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A Doctor's Guide to Making Endometriosis Less Scary
By Kasthuri Nair
Canis, Bourdel, and Chauvet, doctors from CHU Estaing, recently published an article titled “Endometriosis: frightening the patients is not an acceptable alternative to inadequate surgical management and or pathophysiology ignorance” in Fertility and Sterility. Their paper delineated proper health practices…
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Pain catastrophizing, perceived injustice, and pain intensity impair life satisfaction
By Deniz Kocas
Cognitive appraisals have been shown to have an effect on the experience of pain. Notably, perceived injustice and pain catastrophizing have been shown to play a role, but are rarely examined together. In addition, variability in appraisal processes has been…
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Personalised Medicine for Endometriosis?
By Özge Özkaya
The lining of the uterus of women with endometriosis is different from that of women without the disease even if they have chronic pelvic pain found a study published in the scientific journal Biology of Reproduction. The difference is found…
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Oral Contraceptives and Low-Cost Progestins to Reduce Endometriosis-Associated Pain
By Özge Özkaya
Most women with endometriosis-associated pain did not feel the need to use expensive progestin or undergo surgery. Instead, they were satisfied with a low-cost progestin to treat their symptoms. This is according to a study published in the journal Fertility…
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Effectiveness of the Endometriosis Symptom Diary
By Kasthuri Nair
Seitz et al., a research group from Bayer AG and the University of Giessen, recently published an article titled “Patterns of missing data in the use of the endometriosis symptom diary” in BMC Women's Health. The authors were analyzing data…
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Fallopian Tube Capability in Women with Pelvic Endometriosis and Adenomyosis
By Kasthuri Nair
Xia et al. recently published a paper titled “Effects of pelvic endometriosis and adenomyosis on the ciliary beat frequency and muscular contractions in the human fallopian tube” in Reproductive Biology and Endocrinology. This research group primarily from Shanghai Jiaotong University…
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The comparison of Chinese women in terms of risk factors, genetics and treatment of endometriosis
By Hale Goksever Celik
Endometriosis is characterized by endometrial implants outside of the uterine cavity. There is a wide spectrum of symptoms of this disease including dysmenorrhea, chronic pelvic pain, dyspareunia, extragenital symptoms. The pathogenesis of endometriosis appears to be multifactorial, including ectopic endometrial…
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Difficulties Associated with Diagnosing Ascites and Encapsulating Peritonitis in Endometriosis
By Kasthuri Nair
De Magalhães et al. recently published a paper titled “Ascites and Encapsulating Peritonitis in Endometriosis: a Systematic Review with a Case Report” in Revista Brasileira de Ginecologia e Obstetrícia. The team from the Universidade Federal do Ceará and the Universidade…
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Abnormal Regulation of Pathways Seen in Endometriosis
By Kasthuri Nair
Sikora et al., a team from the Medical University of Silesia in Katowice, published a study in the Archives of Gynecology and Obstetrics titled “The role of complement components C1q, MBL and C1 inhibitor in the pathogenesis of endometriosis.” It has been said that complement system…
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Stenoses in the colorectal anastomose sites after DIE surgery
By Hale Goksever Celik
Deep infiltrating endometriosis (DIE) is a particular form of endometriosis that penetrates at least 5 mm under the peritoneal surface. DIE is primarily located in the rectosigmoid junction and the rectum with an incidence of 70% and 90%, respectively. The…
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A Way to Better Diagnose Colorectal Endometriosis
By Özge Özkaya
Combining magnetic resonance imaging (MRI) with computed tomography-based virtual colonoscopy (CTC) can make the assessment of colorectal endometriosis more accurate. This is important because it can help doctors plan the surgery better and inform their patients. In order to evaluate…
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Non-coding RNAs in endometriosis
By Dr. Youngran Park
The pathophysiological mechanisms causing the development of endometriosis, which is a heterogeneous disease remain enigmatic, and a lack of effective biomarkers necessitates surgical intervention for diagnosis. Non-coding RNA (ncRNA) molecules, which are important regulators of cellular function, have been implicated…
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Emerging medical treatments for endometriosis
By Murat Osman
Endometriosis is a disease whereby uterine tissue grows outside the walls of the uterus to the surfaces of other tissues in the body. It is a chronic disease and relies upon estrogen to grow and survive. Current medical therapies take…
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Could Endometriosis Be Caused by Bacteria?
By Özge Özkaya
A new concept called the bacterial contamination hypothesis in endometriosis has been proposed for the first time by researchers in Japan. This means that new potential therapies approaches could exist for this condition in addition to the conventional estrogen-suppressing therapies.…
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Exosomal miR-214 from endometrial stromal cells inhibits endometriosis fibrosis.
By Dr. Youngran Park
Fibrosis is an important pathological feature of endometriosis. Novel therapies targeting the mechanisms of fibrosis in endometriosis are indispensable for the development of strategies to prevent and treat endometriosis. Previous microarray studies have detected some miRNAs that are aberrantly expressed…
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Extending the Female Fertility Clock
By Kasthuri Nair
Varela, Sanchez-de-Puerta, and Garcia-Velasco are a group of scientists from various institutions in Spain and they recently published a review article titled “Fertility, IVF and reproductive genetics” in Current Opinion in Obstetrics and Gynecology. In this publication, the authors discussed…
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HOXA10: A Culprit in Endometriosis Disease Progression
By Kasthuri Nair
Zheng et al., a group of authors from the Aerospace Center Hospital in Bejing and from the First Affiliated Hospital of Wenzhou Medical University in Wenzhou, recently published a paper in Reproductive Sciences entitled “Decreased Expression of HOXA10 May Activate the…
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How Does Endometriosis Affect the Sexual Satisfaction of Men?
By Özge Özkaya
Although the majority of men whose partner has endometriosis are satisfied or very satisfied with their sexual relationship, the proportion of men who are not sexually satisfied is higher among those whose partner has endometriosis compared to those whose partner…
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Most Effective Embryo Transfer Strategy
By Kasthuri Nair
Bourdon et al., a group of scientists mainly from the Centre Hospitalier Universitaire, recently published a paper in PLOS ONE titled “The deferred embryo transfer strategy improves cumulative pregnancy rates in endometriosis-related infertility: A retrospective matched cohort study.” This study…
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Reproductive delay and social egg freezing
By Yu Yu
The data collected from Office for National Statistics in England and Wales has suggested a major shift in the timing of motherhood. In the mid-1970s, the average age of motherhood was 26.4 years of age to, while in 2016, it…
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Endometriosis From an Epigenetic Lens
By Kasthuri Nair
Samadieh et al. from the Royan Institute for Reproductive Biomedicine, recently published an article in Reproductive Sciences titled “Epigenetic Dynamics of HOXA10 Gene in Infertile Women With Endometriosis.” In this paper, the researchers wanted to observe HOXA10 gene expression in…
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Treatment of Endometriosis in Adolescents
By Özge Özkaya
Most women with endometriosis who have been treated with Lupron plus add back as adolescents felt the treatment was effective in reducing the pain caused by the condition, according to a study published in the Journal of Pediatric & Adolescent…
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Using the "Mushroom Cap" sign to describe endometriotic masses
By Murat Osman
Endometriosis is a disease whereby ectopic endometrial cells attach and grow outside of the uterus. A number of imaging techniques have been used to evaluate and assess endometriotic lesions. Magnetic resonance imaging (MRI) is a type of imaging modality used…
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Endometrial stem cells and Endometriosis
By Dr. Youngran Park
Human endometrium is a cyclically proliferative tissue, and this monthly regeneration is likely mediated by endometrial stem (or progenitor) cells.The upper functional layer of the endometrium breaks down and is shed into the uterine cavity during menstruation. Re-epithelialization and repair…
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Endometriosis can Adversely Affect Oocyte Quality
By Kasthuri Nair
Kasapoglu et al. recently published a study in Gynecological Endocrinology titled “Detrimental effects of endometriosis on oocyte morphology in intracytoplasmic sperm injection cycles: a retrospective cohort study.” In this paper, they compared the oocytes recovered from women who have endometriosis…
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An Unusual Case "Free Floating Omental Endometrioma"
By Kasthuri Nair
Capaccione et al. published an article in Radiology Case Reports titled “Massive endometrioma presenting with dyspnea and abdominal symptoms.” This publication is centered around a particularly unique case report of a woman who was ultimately diagnosed with endometriosis. The patient…
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Recurrence of Deep Infiltrating Endometriosis
By Yu Yu
There are mainly three types of endometriotic lesions. These are ovarian endometriosis, superficial peritoneal endometriosis, and deep infiltrating endometriosis (DIE). The latter is often described as a lesion with greater than 5 mm invasion of the peritoneal surface. DIE lesions…
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A How-To Guide for Endometriosis Surgery
By Kasthuri Nair
The European Society for Gynaecological Endoscopy (ESGE), ESHRE, and the World Endometriosis Society (WES) recently published a document titled “Recommendations for the surgical treatment of endometriosis—part 1: ovarian endometriomas.” This publication provides surgeons with recommendations for the technical aspects of…
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Collaboration Between the Surgical and Medical Experts of Endometriosis Needed
By Murat Osman
The authors of this perspective article aim to initiate a dialogue regarding the current evidence regarding the surgical and medical treatment of endometriosis. In their view, the quality of data regarding the outcomes of surgery for endometriosis is lacking and…
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Ectopic Pregnancy Risk Factors
By Kasthuri Nair
Jacob, Kalder, and Kostev recently published an article titled “Risk factors for ectopic pregnancy in Germany: a retrospective study of 100,197 patients” in German Medical Science. The retrospective German study hoped to elucidate the risk factors for ectopic pregnancies. The…
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The Past, Present, and Future of Diagnosing Endometriosis
By Kasthuri Nair
This review titled “Endometriosis: Epidemiology, Diagnosis and Clinical Management” published in Current Obstetrics and Gynecology Reports examines the distribution and factors associated with endometriosis. The analysis by Parasar, Ozcan, and Terry also delineates potential biomarkers and risk factors that could…
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Endometriosis and its pro-fibrotic nature.
By Dr. Youngran Park
Endometriosis is currently defined as the presence of endometrial epithelial and stromal cells at ectopic sites. However, with advances in disease knowledge, several vital issues challenge this old definition. Especially, endometrial stromal and glands have been shown to represent only…
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Blood vessels formation in endometriosis
By Yu Yu
The endometrium undergoes dynamic changes during the menstrual cycle. Estrogen-driven angiogenesis is associated with the proliferative phase, and progesterone-driven vascular maturation occurs in the secretory phase. Hence, it is reasonable that the vascularization of endometriosis is also under complex regulation…
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Which Endometriosis Treatment is Better: NETA or Extended-cycle OC (Seasonique®)?
By Kasthuri Nair
Scala et al. recently shared the findings of their patient preference prospective study in a journal article titled “Norethindrone acetate versus extended-cycle oral contraceptive (Seasonique®) in the treatment of endometriosis symptoms: A prospective open-label comparative study,” which was published in the…
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Novel lipid biomarkers may make early detection of endometriosis possible
By Murat Osman
Currently, specific clinical diagnostic indicators for the early detection of endometriosis have not been found with enough specificity and sensitivity for widespread use. Novel diagnostic biomarkers are needed that are both effective and non-invasive to detect endometriosis as early as…
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Endometriosis “Changes” the Brain
By Özge Özkaya
Endometriosis changes the electrical properties of the brain as well as gene expression, according to a study by Yale researchers. These changes increase sensitivity to pain, anxiety, and depression. “While medications can be used to treat endometriosis directly, the effects…
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When Endometriosis Becomes Malignant
By Kasthuri Nair
Anglesio and Yong recently wrote a review titled “Endometriosis-associated Ovarian Cancers” that was published in Clinical Obstetrics and Gynecology. This review explored the relationship between endometriosis and ovarian cancers. It is important to note that this review is a compilation of…
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Endometriosis Impacts Many Aspects of a Woman’s Life
By Özge Özkaya
Endometriosis has a severe negative impact not only on the physical health of a woman but also on other aspects of her life including optimism and self-esteem. This is according to an Australian study published in the Journal Healthcare for…
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Women with Endometriosis Should Not Worry About Ovarian Cancer
By Kasthuri Nair
Kvaskoff, Horne and Missmer recently published an article in The Lancet titled “Informing women with endometriosis about ovarian cancer risk.” This article was written to address the growing concern surrounding the information that women suffering from endometriosis are at increased…
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Intestinal Endometriosis and Colorectal Cancer versus T4 Colorectal Cancer
By Kasthuri Nair
Ishii et al. recently published a paper titled “Intestinal endometriosis combined with colorectal cancer: a case series” in the Journal of Medical Case Reports. This case report follows 7 Japanese women who have intestinal endometriosis and colorectal cancer. These women…
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How to Minimize the Costs Associated with Endometriosis Care
By Kasthuri Nair
Paolo Vercellini, Maria Pina Frattaruolo and Laura Buggio, from Milan, Italy, recently published an editorial titled “Toward minimally disruptive management of symptomatic endometriosis: reducing low-value care and the burden of treatment” in Expert Review of Pharmacoeconomics & Outcomes Research. The…
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The effect of endometriosis on preterm birth risk
By Demet Candaş Green
Some studies show that women with endometriosis develop significant complications during pregnancy that lead to preterm labor, and newborns of these women often need neonatal intensive care unit admissions. However, other studies argue that endometriosis have no significant effect on…
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Laparoscopic Bowel Resection Can Be Beneficial Rectosigmoid Endometriosis
By Kasthuri Nair
Riiskjær et al. recently published a paper titled “Pelvic Pain and Quality of Life Before and After Laparoscopic Bowel Resection for Rectosigmoid Endometriosis: A Prospective, Observational Study” in Diseases of the Colon & Rectum. This paper focuses on the effects…
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The Use of Resveratrol as an Adjuvant Treatment of Pain in Endometriosis
By Dr. Youngran Park
Endometriosis is considered a predominantly estrogen-dependent disease, and therefore hormonal suppression might be an attractive medical approach to treat this disease and its symptoms. Resveratrol is a natural phytoestrogen synthesized by plants and has known to have side effects such…
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Biomarker Networks Might Help Reveal the Mechanism Behind Endometriosis
By Kasthuri Nair
Scientists have yet to uncover the molecular mechanisms that promote endometriosis disease progression. Xiao et al. recently published a study in Experimental and Therapeutic Medicine where they hoped to shed new light on the pathogenesis of endometriosis. In their study…
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The Deregulated Molecular Functions Involved in Malignant Transformation of Endometriosis to Endometriosis-Associated Ovarian Carcinoma
By Dr. Youngran Park
Endometriosis-associated ovarian cancer (EAOC) is postulated to be transformed from endometriosis. Though different deregulated functional areas were proposed accounting for the pathogenesis of EAOC transformation, there is a lack of data-driven analysis to prove this. To understand the EAOC pathogenesis…
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Does asthma increase the risk of endometriosis?
By Demet Candaş Green
Previous studies have shown an association between asthma and endometriosis but with inconsistency. It is still unclear whether women who have asthma are at a higher risk of endometriosis than women without asthma symptoms. Peng et al., conducted a large…
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How good are the current guidelines on endometriosis?
By Dr. Youngran Park
The endometriosis was first described in 1860, yet the etiology and pathogenesis remain poorly understood. Treatment strategies vary significantly between disease severity and the symptoms of pain and/or subfertility. These challenges have resulted in multidirectional research, and the comparability of…
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Changes in Complement Proteins Affect Infertility in Women with Endometriosis
By Kasthuri Nair
Palomino et al. recently published a paper titled “The endometria of women with endometriosis exhibit dysfunctional expression of complement regulatory proteins during the mid-secretory phase” in the Journal of Reproductive Immunology where they look at the expression of CRPs during the menstrual cycle of…
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Can Ovarian Stimulation Increase Endometrioma Volume?
By Kasthuri Nair
Seyhan et al. recently published a paper titled “Do endometriomas grow during ovarian stimulation for assisted reproduction? A three-dimensional volume analysis before and after ovarian stimulation” in Reproductive BioMedicine Online. The authors initially believe that ovarian stimulation, often used in…
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Bowel Function not Affected by Type of Surgery in Deep Rectal Endometriosis, Clinical Trial Shows
By Özge Özkaya
Conservative surgery for the management of deep rectal endometriosis does not seem to improve the function of the digestive and urinary system compared to more radical surgery according to a new study by French researchers published in the scientific journal Human…
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Ectoenzymes as endometriosis biomarkers
By Yu Yu
The diagnosis of endometriosis is often delayed by 7 to 11 years because of the lack of a non-invasive diagnostic test. The ovarian endometriomas occur in about 17%-44% of women with endometriosis and cysts which contain endometrial tissue and fluid…
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By Laura ArdighieriEffects of osteopathic manipulative therapy in patients with colorectal endometriosis
By Laura Ardighieri
Alternative treatments have been used for colorectal endometriosis, between them Chinese medicine, acupuncture and more recently osteopathic manipulative therapy. The osteopathic manipulative therapy has been shown to reduce the chronic pain working on muscular contractions due to vicious analgesic positions.…
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How Could Doctors Reduce Risk of Complications Following Rectal Endometriosis Surgery?
By Özge Özkaya
Introducing a temporary opening, known as a stoma, in the abdomen of patients that are operated for rectal endometriosis to collect waste products could reduce the risk of complications such as anastomotic leakage. This is according to a study by…
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Stress affects endometriosis negatively
By Demet Candaş Green
Stress contributes to many chronic health problems – endometriosis is one of them. Given that women with endometriosis are under more stress and pain, often with the added stress of infertility, it is important to understand the relationship between stress…
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EFA Medical Conference 2017: "Hormone and Cytokine Sensitivity in Endometriosis" Presentation by Dr. Robert Taylor
By Kasthuri Nair
The first presenter of the “Estrogen from Inflammation to Cancer: A Distant Link?” section of EFA 2017 Medical Conference was Dr. Robert Taylor from Wake Forest University Health Sciences. Dr. Taylor’s presentation was titled “Hormone and Cytokine Sensitivity in Endometriosis.”…
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EFA Medical Conference 2017: "Breast Cancer in Young Women; Early Diagnosis Timely Intervention" Presentation by Dr. Stephanie Bernik
By Kasthuri Nair
Dr. Stephanie Bernik is the Chief of Surgical Oncology of Surgery and General Surgery at the Lenox Hill Hospital. She recently presented at the EFA 2017 Medical Conference, and her presentation was titled “Breast Cancer in Young Women; Early Diagnosis…
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Treatment of minimal endometriosis in infertile women
By Demet Candaş Green
For women with mild/minimal endometriosis, European Society of Human Reproduction and Embryology (ESHRE) recommends the removal of endometriotic lesions to improve fertility and increase pregnancy rates. For women undergoing assisted reproductive treatment, there is ongoing debate whether surgical removal of…
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EFA Medical Conference 2017: "Prophylactic Mastectomy and Breast Reconstruction" Presentation by Dr. Oren Lerman
By Özge Özkaya
Dr. Oren Lerman, a plastic and reconstructive surgeon at Lenox Hill Hospital in New York City, described the reconstructive options of a woman who has been or is going to go through a mastectomy (removal of breast tissues) whether it…
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EFA Medical Conference 2017: "Endometriosis: hormonal or surgical? My reality!" Presentation by Dr. Harry Reich
By Kasthuri Nair
Dr. Harry Reich, the Former Director of Advanced Laparoscopic Surgery at Columbia University Department of OBGYN, was the last speaker in the Mission and History part of the EFA 2017 Medical Conference. His presentation was titled “Endometriosis: hormonal or surgical?…
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Reducing side effect of estrogen based therapy by using Tissue-Selective Estrogen Complex
By Yu Yu
The aberrant regulation of the ERα level in endometriosis and other estrogen-related diseases makes it a promising target for therapy. However, the standard beneficial roles of estrogen in specific target tissues, e.g., the bone, can be primarily affected by such…
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Endometriosis and Oxidative Stress
By Dr. Youngran Park
The etiology of endometriosis is still unclear. However, it is now widely accepted that oxidative stress, defined as an imbalance between reactive oxygen species (ROS) and antioxidants, may be implicated in the pathophysiology of endometriosis causing a general inflammatory response…
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Effects of acupuncture for the treatment of endometriosis-related pain
By Murat Osman
Acupuncture has been seen to offer chronic pain relief most likely due to multiple effects including analgesia and anti-inflammatory changes. Current therapy for endometriosis includes pharmacological and surgical methods. Symptom relief using other supplementary therapies such as acupuncture has been…
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A key cytokine in endometriosis can be targeted for endometriosis treatment
By Demet Candaş Green
Immune system dysfunction has been implicated in the development of endometriosis. One study showed that 95% of cells found in the peritoneal fluid of women with endometriosis are macrophages with impaired phagocytic function, which are unable to eat away unwanted…
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Biomarkers as a Diagnostic Tool
By Kasthuri Nair
Ahn, Singh and Tayade discuss the difficulties and delay in diagnosing Endometriosis in their paper titled “Biomarkers in endometriosis: challenges and opportunities.” Thus far research has identified a multitude of potential biomarkers that are found in various parts of the…
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The Role of Natural Killer Cells in the Development of Endometriosis Unravelled
By Özge Özkaya
Specialized immune cells called natural killer cells found in the peritoneal fluid of women with severe endometriosis may facilitate the development of the disease, according to a study published in the American Journal of Reproductive Immunology. This finding could help…
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A Two-Wave Molecular Mechanism for Endometriosis Disease Progression
By Kasthuri Nair
Kobayashi et al. recently published a review paper in Molecular Medicine Reports titled “Pathogenesis of endometriosis: The role of initial infection and subsequent sterile inflammation,” which discusses at length the role of non-specific bacterial infection and sterile inflammation in the…
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By Vishaan NurseyEndometriosis linked with increased risk of cancer and frequency of future surgical procedures
By Vishaan Nursey
The purpose of this data research was to determine how women with endometriosis might be predisposed to other medical conditions later on in their lives. In order to determine if endometriosis affected health outcomes, a group of Scottish researchers collected…
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Mitogen-Activated Protein Kinase p38 modulates Inflammation in Endometriosis
By Yu Yu
The p38 mitogen-activated protein kinase (MAPK) is a serine/threonine kinase, which transduces signals within the cell in response to various environmental stimuli. In doing so, it mediates intracellular signaling of cytokine production, cell proliferation, and apoptosis amongst many other cellular…
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With so many imaging tools and modalities, which one should be used for endometriosis?
By Murat Osman
Intestinal endometriosis affects 5 to 12% of women with endometriosis and commonly presents as dyschezia, rectal bleeding, cyclic defecation pain, constipation, and diarrhea. Currently, surgical treatment includes segmental rectal resection with colorectal anastomosis, but it is often riddled with complications.…
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Characteristics and location of extrapelvic endometriosis
By Demet Candaş Green
The authors of this study reviewed the medical records of 1000 women with endometriosis from two geographical areas, New Haven, US and Crete, Greece over a 20-year period with a goal of identifying the presence and location of extrapelvic endometriosis…
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Endometriosis and Psychological Health: Butterflies from Deep Wounds
By Kasthuri Nair
Endometriosis is a grueling disease in every sense of the word; however, most of the discussions center on the physical manifestations of the disease. Facchin et al. veer from the beaten path and examine the impact endometriosis have on a…
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Updates in the Field of Endometriosis: Imaging
By Kasthuri Nair
Hoyos, Johnson, and Puscheck wrote a chapter titled “Endometriosis and Imaging” that discusses the imagining technologies that can be used to diagnosis and examine individuals with the disease. This chapter evaluates three types of imagining, namely Ultrasound (US), Magnetic Resonance…
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A Systematic Review of Guidelines for Diagnosis and Management of Endometriosis
By Yu Yu
Guidelines are systematically developed statements derived from best research evidence to improve patient care through informed clinical practice. Appropriate guidelines can reduce unwarranted variations health practice and the implementation of better interventions. Endometriosis commonly has three different manifestations, including peritoneal…
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Cystectomy More Likely to Cause Infertility than Laparoscopic Vaporization
By Özge Özkaya
Treating patients with endometriotic ovarian cysts using laparoscopic vaporization may be better than treating them with cystectomy, or the surgical removal of cysts, regarding fertility. This information is according to a study conducted by Japanese scientists and published in the Asian…
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Surgical treatment of colonic endometriosis
By Demet Candaş Green
In this study, the authors provide a brief report published in the journal "The American Surgeon" which retrospectively reviewed the therapy outcomes in eight consecutive patients who had a laparoscopic surgical intervention for deeply infiltrating endometriosis (DIE) at Anne Arundel Medical Center. The…
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The Potential Molecular Mechanisms that Drive Endometriosis Progression
By Kasthuri Nair
Endometriosis is a mysterious disease in that the exact mechanism that causes the illness is still at large. Yang et al. recently published a paper in the European Review for Medical and Pharmacological Sciences that hopes to elucidate the molecular…
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Endometriosis : A Whole Body Disease
By Kasthuri Nair
Endometriosis is a disease that impacts multiple parts of an individual’s body. Seminars in Reproductive Medicine recently published a paper by Alderman III et al. entitled “The Systemic Effects of Endometriosis” explores the various comorbidities that can affect individuals suffering…
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Abdominal Wall Endometriosis
By Kasthuri Nair
Endometriosis can present itself in many places including within the pelvic organs, the more common manifestation, and outside of the pelvic organs, often referred to as extrapelvic endometriosis. One form of extrapelvic endometriosis is Abdominal Wall Endometriosis (AWE). Yela, Trigo,…
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The Involvement of the Blood Clotting System in Endometriosis
By Özge Özkaya
The blood clotting system might be over-active in women with endometriosis, found a study published in the scientific journal Reproductive Sciences. Although the authors stated that there is not enough evidence to suggest that over-coagulation may be directly causing endometriosis…
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The Most Cost Effective Medical Treatment to Prevent Recurrent Endometriosis
By Özge Özkaya
A new study conducted in China found that a class of drugs called Gonadotropin-releasing hormone agonists (GnRH-a) is more cost effective for the treatment of recurrent endometriosis despite the fact that they are more expensive than oral contraceptives. The results…
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Endometriosis and Productivity at Home and in the Workplace
By Kasthuri Nair
Soliman et al. recently published an original paper in the Journal of Managed Care and Specialty Pharmacy that discusses the impact that endometriosis symptoms have on an individual’s productivity level at home and work. This publication is titled “The Effect…
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Hormonal Contraceptives and Endometriomas
By Kasthuri Nair
Hormonal contraceptive has recently become a popular choice of birth control for many women. The European Journal of Obstetrics & Gynecology and Reproductive Biology recently published an article entitled “Incidence of ovarian endometrioma among women with peritoneal endometriosis with and…
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By Asli Bahadirli TalbottInhibition of key neurotransmitter could reduce endometriosis-related pain
By Asli Bahadirli Talbott
This study published in the scientific journalMolecular MedicineReports[link] by Lian et al. from Shanghai, China, aims to explore the relationship between transient receptor potential vanilloid type 1 (TRPV1) and endometriosis-associated pain. Pain is the most common symptom for women with…
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ICSI Outcomes for Laparoscopic Intervention of Endometriosis
By Kasthuri Nair
Women with endometriosis can have trouble conceiving and often turn to fertility treatments for help. Guler et al. recently published a paper in Systems Biology in Reproductive Medicine titled “The Impact of laparoscopic surgery of peritoneal endometriosis and endometrioma on…
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How ERα is regulated in endometriosis?
By Yu Yu
Endometriosis pathogenesis is largely influenced by estrogen. Ectopic endometrium has altered expression of ERα compared to the eutopic endometrium. It is unclear what biological processes regulate such alteration. The article by Toderow et al. in Archives of Gynecology and Obstetrics…
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The Unresolved Link Between Sexual Dysfunction and Endometriosis
By Kasthuri Nair
Barbara et al. recently published a systematic review of literature in Reproductive Sciences titled “What Is Known and Unknown About the Association Between Endometriosis and Sexual Functioning” that delves into the effects that endometriosis has on female sexual dysfunction. Endometriosis…
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T-Cell Dysfunction May Worsen Endometriosis
By Murat Osman
Researchers from the Kyoto Prefectural University of Medicine, Japan, have found that T regulatory lymphocytes (Treg) may be the reason for the formation of the chronic inflammatory environment involved in endometriosis, a study published in The Journal of Clinical Endocrinology &…
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Body size, adult height and endometriosis
By Asli Bahadirli Talbott
Endometriosis is associated with lean body size during childhood, adolescence, and adulthood; tall total adult height; and tall sitting height, found a study published in the scientific journal, Human Reproduction. This study aimed to investigate the relationships between body size across…
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A potential indicator of invasive endometriosis.
By Asli Bahadirli Talbott
Furuya & Masuda et al., in their recent article that will be published in Acta Obstet Gynecol Scand, report that the protein encoded by ZEB1 gene (Zinc finger E-box-Binding homeobox) is a potential indicator of invasive endometriosis. ZEB1 is a transcription factor that has been implicated…
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Could the cell surface protein "EWI-2" be the new diagnostic marker for endometriosis?
By Murat Osman
Further Understanding: Researchers from the Reproductive Medicine Center of Wuhan University sought to observe the differential expression of EWI-2, (a cell surface protein and an early activation marker, also known as IGSF8 - Immunoglobulin superfamily member 8) in 145 women…
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Endometriosis as a Barrier to Fertility
By Murat Osman
Some of the articles in the from the journal "Acta Obstetricia et Gynecologica Scandinavica (AOGS) issue are discussed in further detail below: Pain caused by endometriosis has been seen to significantly impact women's physical, psychosocial, and sexual health. Although endometriosis has been…
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TFF3 May Be Involved in Endometriosis Research Suggests
By Özge Özkaya
Levels of a protein called TFF3 are significantly increased in the peritoneal cavity (the abdominal space) of women with endometriosis, found a study published in the scientific journal Reproductive Sciences. This increase was in line with levels of other known…
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Endometriosis Reduces Chance of Having a Baby Even with Assisted Reproduction, Study Shows
By Özge Özkaya
Endometriosis significantly decreases the likelihood of conceiving even with assisted reproductive technique such as in vitro fertilization (IVF) and Intracytoplasmic sperm injection (ICSI), according to a study published in the European Journal of Obstetrics & Gynecology and Reproductive Biology. In…
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How rats can help improve colon endometriosis treatment in humans
By Demet Candaş Green
Colorectal endometriosis forms about 3–37% of all deep infiltrating endometriosis (DIE) cases. DIE is a highly invasive type of endometriosis, occurs when ovarian endometriomas overgrow and rupture, releasing their contents into the abdominal and pelvic cavity, resulting in the formation…
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By Ezio RosatoWomen with Endometriosis Undergoing Surgery Often Require Further Treatment
By Ezio Rosato
Recurrence of endometriosis is common even in women who underwent surgery, a new study confirmed. This suggests that women with endometriosis should be closely followed up even after treatment with surgery. For the study published online in the Journal of…
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Immune substances in peritoneal fluid for endometriosis diagnosis and armamentarium
By Yu Yu
Cytokines are immune substances secreted by a broad range of cells within the body, including immune cells like the macrophages, B lymphocytes, T lymphocytes, mast cells, and non-immune cells such as the endothelial cells and fibroblasts. They are important in…
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Complexity of Urinary Tract Endometriosis: Highlights from a Review
By Murat Osman
Understanding the Clinical Complexity of Urinary Tract Endometriosis: Highlights from a Review While endometriosis predominantly affects the pelvic reproductive organs, spread to the urinary tract has also been observed and requires a different subset of surgical techniques for treatment. Accurate…
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By Karime Kalil MachadoEndometriosis doubles the risk of sexual dysfunction
By Karime Kalil Machado
Women with endometriosis are more than two times as likely to present sexual dysfunction as compared to women without the disease, according to a study published in Gynecologic Endocrinology. In this study conducted by researchers from the University of São…
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Laparoscopic Hysterectomy as Effective as Total Abdominal Hysterectomy, Study Suggests
By Ezio Rosato
Laparoscopic hysterectomy, a minimally invasive surgical procedure that is used to remove the uterus, results in similar rates of disease-free survival among women with stage 1 endometrial cancer as the standard abdominal hysterectomy, showed a study published in The Journal…
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Endometriosis Can Reduce Sleep Quality and Negatively Impact Patient’s Quality of Life Study Suggests
By Özge Özkaya
Most women with endometriosis of the posterior cul-de-sac, experience poor sleep quality, excessive daytime sleepiness and insomnia, according to a study published in the European Journal of Obstetrics & Gynecology and Reproductive Biology. Poor sleep quality can reduce the quality…
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