Selected Blood Inflammatory Biomarkers May Help Identify Endometriosis

Selected Blood Inflammatory Biomarkers May Help Identify Endometriosis By Özge Özkaya

Levels of inflammatory biomarkers in the blood differ between women with endometriosis and those without the disease. Levels of some biomarkers also differ according to the stage of endometriosis. This is according to a new study by Polish scientists published…

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The effects of endometriosis on life satisfaction.

The effects of endometriosis on life satisfaction. By Bahar Yuksel

Endometriosis is well-known for its debilitating effects on women suffering from it. In the review conducted by Masoumeh Namazi et al, the authors have collected studies searching for the wellbeing of women with endometriosis. They have analyzed 46 studies that…

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Endometrial receptivity after the removal of ovarian endometriotic cysts

Endometrial receptivity after the removal of ovarian endometriotic cysts By Nasuhi Engin Aydin

Mikhaleva and associates from the "Russian Research Institute of Human Morphology" published their results in “Reproductive Sciences” yielding their novel morphological findings of eutopic endometria in patients following surgical excision of endometriotic ovarian cysts. Current therapeutic measures are targeting to…

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Managing the physical and emotional effects of endometriosis

Managing the physical and emotional effects of endometriosis By Hale Goksever Celik

Endometriosis is known to affect 5-10% of the general population, but some women are underdiagnosed due to physical and psychological disability. Due to the symptoms including dysmenorrhea, dyspareunia, chronic pelvic pain and infertility, endometriosis has a negative effect on the quality…

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Impaired fertility potential in endometriosis patients

Impaired fertility potential in endometriosis patients By Hale Goksever Celik

Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis and sperm movements. Garcia-Fernandez and García-Velasco, from Edinburgh, UK and Madrid, Spain, published a mini-review titled “Endometriosis and Reproduction: What We Have…

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The improvement of fertility rate and symptoms of superficial endometriosis following laparoscopic peritoneal stripping

The improvement of fertility rate and symptoms of superficial endometriosis following laparoscopic peritoneal stripping By Selma Oransay

Pain, in the form of diverse entities, including dyspareunia, dysuria, dyschezia, is the main symptom of endometriosis patients. The severity of pain is independent of the extent and the location of the disease, and generally causes a negative impact on…

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Vitamin D supplementation, endometriosis symptoms and metabolic profiles

Vitamin D supplementation, endometriosis symptoms and metabolic profiles By Hale Goksever Celik

Patients with endometriosis suffer from dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. These women are also at higher risk for ovarian and breast cancer, cardiovascular events, and metabolic abnormalities. Several medical and surgical alternatives have been recommended to these patients…

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The role of hormonal treatment after endometriosis surgery

The role of hormonal treatment after endometriosis surgery By Bahar Yuksel

Postoperative hormonal suppression after endometriosis surgery still does not have a uniform approach. The meta-analysis study conducted by Zakhari et al. aimed to find a significant answer regarding this burden. They analyzed the database systems including MEDLINE, Embase, Cochrane CENTRAL,…

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Live Birth Rate in Women Who Underwent Fresh Embryo Transfer Using Freshly Retrieved Donor Oocytes

Live Birth Rate in Women Who Underwent Fresh Embryo Transfer Using Freshly Retrieved Donor Oocytes By Hale Goksever Celik

One of the important clinical findings in women with endometriosis is reproductive problems. Infertility can be encountered in up to 50% of women with endometriosis and up to 50% of women with infertility can be diagnosed with endometriosis. Several pathophysiologic…

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What is the cause of Dienogest-resistance in patients with endometrioma?

 What is the cause of Dienogest-resistance in patients with endometrioma? By Selma Oransay

Endometriosis may cause infertility in women, leading to adhesions in the pelvis, besides affecting the ovaries. Clinicians concern about the child-bearing desire of their patients when treating them surgically or with hormonal therapy. Dienogest (DNG) is a kind of progestin,…

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The "metabolome" of follicular fluid in deep infiltrating endometriosis

The By Yu Yu

Endometriosis encompasses three different phenotypes, being superficial endometriosis, deep infiltrating endometriosis (DIE), and ovarian endometrioma (OMA). The latter is the most severe form and has an unfavorable impact on ovarian function. Infertility associated with endometriosis has been linked to chronic…

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Analysis of women with endometriosis-related pain before the multidisciplinary endometriosis care management

Analysis of women with endometriosis-related pain before the multidisciplinary endometriosis care management By Irem Onur

Endometriosis patients are generally treated by a single provider and they frequently report dissatisfaction with care. To decrease diagnostic delays, improve pain management, and promote patient satisfaction, multidisciplinary endometriosis centers emerged. But, baseline data assessing the efficacy of the multidisciplinary…

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High-dose progestin intake and sexual functions in endometriosis patients

High-dose progestin intake and sexual functions in endometriosis patients By Selma Oransay

Dr. Oppenheimer et al. from the Department of Reproductive Medicine and Fertility Preservation of Antoine Beclere University Hospital, Clamart, France, recently published this bi-center observational prospective study in "Acta Obstetrica et Gynecologica Scandinavica". The study was designed to put forth…

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Endometriosis, Fatigue and Productivity

 Endometriosis, Fatigue and Productivity By Ellen Tumimbang

Fatigue is one of the prominent and distressing symptoms of endometriosis-associated with insomnia, depression, pain, occupational stress, and reduced health-related quality of life. Endometriosis-related fatigue causes significant impairments in workplace productivity and daily activities of women with endometriosis. Loss of…

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Postoperative pregnancy rate in infertile women with deep infiltrating endometriosis

 Postoperative pregnancy rate in infertile women with deep infiltrating endometriosis By Hale Goksever Celik

Deep infiltrating endometriosis (DIE) is fibrous/muscular infiltration of organs and anatomical structures containing endometrial tissue below the peritoneum regardless of the depth of infiltration. Another definition describes DIE as infiltration of the peritoneum by endometriotic lesions deeper than 5 mm. Pain,…

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Insoluble Dilemma of Adenomyosis: Diagnosis, Management, and Treatment  - Errico Zupi, MD

Insoluble Dilemma of Adenomyosis: Diagnosis, Management, and Treatment  - Errico Zupi, MD By Selma Oransay

The prevalence of adenomyosis has been reported to range from 1% to 70% in different studies. This large range can be explained by the lack of standard diagnostic criteria by imaging modalities or pathological analyses. Sixty-five% of the women with adenomyosis…

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Implantation failure in endometriosis patients - Jovana Lekovich, MD., PhD.

Implantation failure in endometriosis patients - Jovana Lekovich, MD., PhD. By Hale Goksever Celik

Endometriosis is one of the leading reasons for infertility due to decreased oocyte/embryo quality, fertilization ability, tubal function, and aberrant endometrial receptivity. Whether this failure is caused by oocyte/embryo or eutopic endometrium is one of the investigated topics in endometriosis…

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Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD

Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD By Selma Oransay

The removal of endometrioma may affect ovarian reserve because healthy follicles near endometrioma could also be excised during this procedure. Another concern about the ovarian reserve is that it may be already low before the surgery. Anti Mullerian Hormone (AMH)…

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In vitro fertilization protocols in endometriosis patients - Pinar Kodaman, MD., PhD.

In vitro fertilization protocols in endometriosis patients - Pinar Kodaman, MD., PhD. By Hale Goksever Celik

Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis, and sperm movements. Even though the disease stage and presence of endometrioma is negatively correlated with infertility, it is unpredictable which women…

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Could Cosmetics and Personal Care Products Increase the Risk of Endometriosis?

Could Cosmetics and Personal Care Products Increase the Risk of Endometriosis? By Özge Özkaya

The use of cosmetics and personal care products may be increasing the risk of endometriosis according to a study by Spanish researchers that was published in the journal "Environmental Research". This finding suggests that restricting the use of these products may…

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Endometrioma size and anti-Müllerian hormone levels

Endometrioma size and anti-Müllerian hormone levels By Hale Goksever Celik

Endometriotic lesions are encountered in different locations in the pelvic cavity, including but not limited to the ovaries, the pouch of Douglas, the ureters, the bladder, and the bowel. Cystic endometriosis lesions located in the ovary are called "endometrioma". Endometriomas have…

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Endometriosis and chronic opioid use

Endometriosis and chronic opioid use By Selma Oransay

The members of the American College of Obstetricians and Gynecologists have declared that gynecologists prescribe opioids after laparoscopic hysterectomy, or for relieving endometriosis pain, although guidelines are not available for when or how to use opioids for the treatment of endometriosis-associated…

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Reduced risk of "small for gestational age baby" following frozen embryo transfer in endometriosis patients

Reduced risk of By Hale Goksever Celik

Infertility is encountered frequently in patients with endometriosis. These women could be managed using assisted reproductive technology (ART) including in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) to achieve pregnancy. However, some adverse obstetric and perinatal outcomes are experienced more…

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A pilot study for Endometriosis Potential biomarkers

A pilot study for Endometriosis Potential biomarkers By Ellen Tumimbang

Endometriosis is one of the most common female health disorders typically causing dysmenorrhea, dyspareunia, and pelvic pain, and may contribute to infertility. It is necessary to identify potential molecular biomarkers for diagnosis and regulatory factors behind the disease. The study…

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Endometriosis and Natural Killer Cell Immunity

Endometriosis and Natural Killer Cell Immunity By Dr. Youngran Park

It is known that approximately 25 to 50% of infertile women have endometriosis, and 30% to 50% of the women with endometriosis have infertility and recurrent pregnancy loss. Previous studies have shown that women suffering endometriosis have abnormal NK cell…

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Segmental bowel resection could be predicted using MRI in patients with rectal endometriosis

Segmental bowel resection could be predicted using MRI in patients with rectal endometriosis By Hale Goksever Celik

The rectum and recto-sigmoid junction are the preferential localisations of bowel endometriosis. The three main surgical approaches are shaving, disc excision, and segmental resection. It is very important to decide the most appropriate surgical method preoperatively and to plan accordingly. …

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Assessment of Reproductive Health for Women With Endometriosis

Assessment of Reproductive Health for Women With Endometriosis By Özge Özkaya

Researchers in Iran developed a new and reliable patient-generated instrument to measure the reproductive health of women with endometriosis. Health providers as well as researchers can use the questionnaire to better understand the impact of the disease on women’s reproductive health…

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Psychometric properties of Endometriosis Health survey-Swedish version

Psychometric properties of Endometriosis Health survey-Swedish version By Hale Goksever Celik

Endometriosis is a chronic estrogen-dependent disease resulting in a broad spectrum of symptoms and signs including dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Additionally, gastrointestinal and urinary systems may be affected by this disease. All of these clinical findings impair…

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Stem cell and exosome therapy

Stem cell and exosome therapy By Dr. Youngran Park

These days, two experimental methods, stem cell, and exosome therapy are getting more attention. Stem cell therapy has shown promising effects in regenerative medicine, including myocardial infarction, nervous system impairment, retinal damage, and liver diseases. Recent studies showed that stem…

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The intensity of pelvic pain is higher in endometriosis patients

The intensity of pelvic pain is higher in endometriosis patients By Irem Onur

Silva  J.B. et al., researchers from Brazil, conducted a case-control study to determine the intensity of clinical pain, the average body composition, and the anthropometric markers including the body mass index, the perimeters (waist, abdomen, hip), and the percentage of…

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Woof Woof – Bone marrow cells are coming

Woof Woof – Bone marrow cells are coming By Yu Yu

Bone marrow contains cells that can travel to multiple organ sites and differentiate into specific tissue cells. Bone marrow-derived stem cells have also been associated with the pathogenesis of endometriosis. These cells can affect epithelial and stromal cell regeneration both…

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The more than expected prevalence of endometriosis in patients with Mullerian abnormalities

The more than expected prevalence of endometriosis in patients with Mullerian abnormalities By Bahar Yuksel

Congenital müllerian anomalies resulting in a spectrum of uterine abnormalities are caused by the abnormal embryologic fusion of the müllerian ducts to form a normal uterine cavity.  They are often unrecognized because they are usually asymptomatic. The presence of a uterine…

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Depression and anxiety levels in "in vitro fertilization" patients with endometriosis

Depression and anxiety levels in By Hale Goksever Celik

Endometriosis is a reproductive-aged and estrogen-dependent disease. The most common symptoms of this disease are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility affecting the quality of life in several aspects mainly the psychological domain. In the literature, there are many studies…

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Endometriosis-related obstetrical complications and their outcome

Endometriosis-related obstetrical complications and their outcome By Selma Oransay

Borisova et al. from the Department of Gynecology and Obstetrics of Peoples' Friendship University, Moskow, Russia, and her colleagues from the Center of Perinatal and Reproductive Medicine of University Perugia, Italy, recently published a review of the literature data about…

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Cellular communications: Exosomes in Endometriosis

Cellular communications: Exosomes in Endometriosis By Dr. Youngran Park

Exosomes have been reported as cell-to-cell communicators, transfer many molecules such as miRNAs, RNAs, and proteins, and their alteration may cause many disease processes, including endometriosis. Considering the role of exosomes and their cargos in a cell to cell communication as important…

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Predictors of voiding dysfunction after surgery for deep endometriosis

Predictors of voiding dysfunction after surgery for deep endometriosis By Selma Oransay

While surgery for deep endometriosis provides relief and improves the quality of life in symptomatic patients for whom medical therapy has limited effect, it may also create postoperative lower urinary tract dysfunction. Moreover, postoperative voiding dysfunction could affect the quality…

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Factors affecting the quality of life of women with endometriosis

Factors affecting the quality of life of women with endometriosis By Timur Seckin

Results from a new study suggest that the quality of life of women with endometriosis is significantly affected by their confidence to manage pain and their belief in the evolution of their condition. In this study, led by Rees M. et…

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Deep Endometriosis or Recto-uterine Obliteration Without Endometrioma

Deep Endometriosis or Recto-uterine Obliteration Without Endometrioma By Selma Oransay

The diagnostic help of ultrasound is increasing by its ability to diagnose deep infiltrating and rectouterine pouch obliteration in patients who are suffering from chronic pelvic pain. Clinicians are used to evaluating the rectal and parametrial areas of the endometriotic…

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The advantages of combined vaginal-laparoscopic approach on voiding dysfunction for rectovaginal endometriosis

The advantages of combined vaginal-laparoscopic approach on voiding dysfunction for rectovaginal endometriosis By Irem Onur

The patients with rectovaginal endometriotic nodules with extensive vaginal infiltration who are managed combined vaginal-laparoscopic approach have a lower risk of postoperative bladder dysfunction when compared to surgery via laparoscopy alone. This is according to a manuscript published in the…

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Inhibiting killer on the move

Inhibiting killer on the move By Yu Yu

The three main forms of endometriosis are superficial, ovarian, and deep endometriosis. The latter is defined by the presence of endometriotic nodules that are deeper than 5 mm. Deep endometriosis is considered the most aggressive and is associated with severe…

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The impact of laser vaporization on reproductive outcomes in women with endometrioma

The impact of laser vaporization on reproductive outcomes in women with endometrioma By Hale Goksever Celik

Despite extensive research, the optimal method for the management of endometriosis still remains unclear. Excisional surgery is claimed with a more favorable outcome than drainage and ablation regarding the recurrence of disease and symptoms. On the other hand, cyst vaporization…

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Progesterone Receptors and Endometriosis.

Progesterone Receptors and Endometriosis. By Ellen Tumimbang

Endometriosis is characterized as a chronic and inflammatory disease in which the specific cause has not been completely understood. Nonetheless, altered estrogen signaling and progesterone resistance are the common attributes of endometriosis. Progesterone resistance is partly attributed to a decrease…

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Immune cells and endometriosis pain

Immune cells and endometriosis pain By Dr. Youngran Park

Endometriosis is an estrogen-dependent inflammatory disorder in women. This disease leads to dysmenorrhea, pelvic pain, and infertility. The immune reaction is one of the most widely accepted pathologies of endometriosis. Estrogen dysfunction stimulates immune cells in the peritoneal cavity affecting…

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Endometriosis prevalence among adolescents with pelvic pain

Endometriosis prevalence among adolescents with pelvic pain By Irem Onur

An updated review conducted by the investigators at EGA Institute for Women's Health, University College London, United Kingdom, in collaboration with Birmingham Women’s and Children’s Foundation Trust of the Institute of Metabolism and Systems Research at the University of Birmingham…

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Reproductive capacity and recurrence rate after surgery for Stage III/IV endometriosis 

Reproductive capacity and recurrence rate after surgery for Stage III/IV endometriosis  By Bahar Yuksel

If gaining fertility back is the main goal, the surgical removal of endometriosis lesions is globally recognized as first-line therapy. Even though, pre- and postoperative hormone therapy leads to a significant decrease in the spread of the disease measured with the…

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Early maternal separation and endometriosis progression in adult mice

Early maternal separation and endometriosis progression in adult mice By Hale Goksever Celik

The quality of life in the women affected by endometriosis depends on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Although several studies have been performed to investigate the underlying pathophysiologic mechanism, it…

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Is Endometriosis More Common Among Women of Certain Race/Ethnicity?

Is Endometriosis More Common Among Women of Certain Race/Ethnicity? By Özge Özkaya

Race/ethnicity seems to have an influence on the prevalence of endometriosis with black women appearing to be less likely to be diagnosed with the disease compared to white women. However, other factors such as access and response to treatment may…

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Hysterectomy as a choise of chronic pelvic pain relief in endometriotic women.

Hysterectomy as a choise of chronic pelvic pain relief in endometriotic women. By Selma Oransay

Sandstrom et al. from the Department of Obstetrics and Gynecology of Umea University, Sweden, found a significant and long-lasting reduction in pain symptoms after hysterectomy among women with confirmed endometriosis and recently published their results in "BJOG". The authors performed…

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Cabergoline or Progesterone not Effective in Rat Model of Endometriosis

Cabergoline or Progesterone not Effective in Rat Model of Endometriosis By Özge Özkaya

Oral treatment with cabergoline or micronized progesterone for four weeks is not effective in the regression of endometriotic implants in a rat model of the disease. This is according to a study published in the "Journal of Investigative Surgery".  Cabergoline…

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Adolescent dysmenorrhea diagnosis and management

Adolescent dysmenorrhea diagnosis and management By Hale Goksever Celik

Endometriosis is usually diagnosed in reproductive-aged women. However, recent literature proved that clinical symptoms of endometriosis are also seen the adolescent girls and young women. Dysmenorrhea, the most common gynecologic complaint among this age group, can develop due to endometriosis.…

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Bone morphogenetic protein and endometriosis

Bone morphogenetic protein  and endometriosis By Nadire Duru

Endometriosis is a chronic disease characterized by the presence of endometrial glands and stroma outside the uterus, associated with several discomforts such as pelvic pain, menstrual disorders, and infertility. Although endometriosis is categorized as a benign lesion, the ectopic endometrial…

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International experts commentary for assisted fertility treatment facilities amidst COVID-19

International experts commentary for assisted fertility treatment facilities amidst COVID-19 By Nasuhi Engin Aydin

A multinational and multi-institutional commentary led by Dr. Alviggi from Italy and Dr.Esteves from Brazil has addressed important issues on assisted reproductive technology treatment amid COVID-19 lockdown suggesting remedies in the journal of "Reproductive Biology and Endocrinology" May 2020 issue.…

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Racial and ethnic disparities and women health

Racial and ethnic disparities and women health By Selma Oransay

The well documented racial and ethnic disparities in Obstetrics and Gynecology in the US make available to use them as an indicator of implicit bias in giving unequal health and care service to minorities. Dr. Bryant from Massachusetts General Hospital,…

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Menstrual Blood Proteins for Endometriosis Diagnosis

Menstrual Blood Proteins for Endometriosis Diagnosis By Ellen Tumimbang

Endometriosis is a gynecological disorder characterized by endometrial tissue outside the uterine cavity. The backflow of menstrual blood from the uterus through the fallopian tubes is thought to be the cause of endometrial tissue growing outside the uterine cavity when…

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Is oocyte cryopreservation useful for fertility preservation in ovarian endometriosis?

Is oocyte cryopreservation useful for fertility preservation in ovarian endometriosis? By Irem Onur

Women with endometriosis tend to have lower fecundity compared to normal couples. Furthermore,  endometrioma itself may reduce the ovarian reserve by altering ovarian physiology in the surrounding healthy ovarian tissue. The treatment for endometrioma is surgical removal in most cases, however,…

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Endometriosis surgery and future pregnancy complications

Endometriosis surgery and future pregnancy complications By Selma Oransay

Endometriosis is one of the known diseases for infertility in the reproductive period of women. Several studies revealed that endometriosis itself maybe the reason for some unfavorable obstetric outcomes. Localization, the type of endometriotic lesions, and the stage of endometriosis…

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Neglected needs of endometriosis and infertility patients during COVID-19 pandemic

Neglected needs of endometriosis and infertility patients during COVID-19 pandemic By Timur Seckin

With the global outbreak of the COVID-19, hospitals canceled surgeries and people are afraid of going to hospitals. However, chronic diseases still need to be managed. Rowe H. and Quinlivan J., researchers from Australia, pointed out the neglected needs of…

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White blood cell neutrophils link to immunosuppressive environment in ovarian endometrioma

White blood cell neutrophils link to immunosuppressive environment in ovarian endometrioma By Yu Yu

Recently the contribution of neutrophils to the pathogenesis of endometriosis has been suggested. Several observations fuelled this suggestion, such as the accumulation of neutrophils in the peritoneal fluid of ovarian endometriosis; neutrophil extracellular traps were found in the peritoneal fluid of…

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Laparoscopic surgery for COVID-19 positive patients: A Dilemma

Laparoscopic surgery for COVID-19 positive patients: A Dilemma By Nasuhi Engin Aydin

COVID-19 pandemic is the most important issue of our days. In this regard, it is crucial to keep health care providers (HCPs) safe and away from contamination. Doctors Without Borders reported that regardless of all preventive measurements, nearly eight percent…

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Resveratrol for infertility: A frenemy?

Resveratrol for infertility: A frenemy? By Selma Oransay

Ovarian aging is defined by an age-specific decline of the functional ovarian reserve. Female ovarian reserve declines progressively with increasing chronological age. Chronic damage by reactive oxygen species results in deterioration and aging through mitochondrial dysfunction, telomere shortening, cohesion dysfunction,…

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miR-92a and progesterone resistance in endometriosis

miR-92a and progesterone resistance in endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. This incidence of this disease is 35% to 50% among those who suffer from chronic pelvic pain and infertility, which has a negative effect on the quality of life and on health. Recent genome-wide associations…

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Are endometriosis patients at higher risk of bipolar disorder?

Are endometriosis patients at higher risk of bipolar disorder? By Irem Onur

Endometriosis patients are prone to develop certain psychiatric disorders, including depression and anxiety, as well as bipolar disorder, according to a nationwide population-based cohort study from Taiwan. Bipolar disorder formerly called manic-depression is a chronic mental disorder characterized by unusual changes…

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Maternal body mass index and neonatal outcomes in women with endometriosis

Maternal body mass index and neonatal outcomes in women with endometriosis By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal-like tissue outside the uterine cavity. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of…

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Hysterolaparoscopy Plus Assisted Reproduction Improves Fertility in Women with Endometriosis

Hysterolaparoscopy Plus Assisted Reproduction Improves Fertility in Women with Endometriosis By Özge Özkaya

Hysteroscopy and laparoscopic surgery is an effective and reliable therapeutic procedure, confirmed a study published in the "Journal of Clinical Medicine". The approach is even more effective when combined with assisted reproductive techniques such as artificial insemination and in vitro…

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Steroid hormone receptors in endometriosis

Steroid hormone receptors in endometriosis By Yohan Suryo

Therapeutics that target the steroid hormones are the standard treatment for women with endometriosis because steroid hormones play an important role in endometrial physiology and pathogenesis of endometriosis. Examples of these therapeutics include anti-estrogens, estrogen receptor (ER) modulators, progestins, and…

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Recurrence following surgery for subtypes of endometriosis

Recurrence following surgery for subtypes of endometriosis By Hale Goksever Celik

Endometriosis is a disease identified by the location of endometrial stromal and glandular cells outside the uterine cavity. It is considered as a gynecological disease of reproductive-aged women. Three subtypes of endometriosis are peritoneal endometriosis which defines the endometriotic lesions…

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Fertility conservation in women with endometriosis

Fertility conservation in women with endometriosis By Selma Oransay

Endometriosis affects 10-15% of women in their reproductive period and almost half of them may need Assisted Reproductive techniques to conceive. Moreover, increased malignancy risk is threatening the women with severe endometriosis in addition to their decreased ovarian reserve. Due…

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Fertility preservation protocols in women with endometriosis

Fertility preservation protocols in women with endometriosis By Hale Goksever Celik

Infertility is one of the major symptoms in women with endometriosis. Childbearing at a delayed age is preferred by the majority of women recently who consult for the demand for fertility preservation procedures. There are several techniques for fertility preservation…

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Urgent Need For Building Resilience

Urgent Need For Building Resilience By Timur Seckin

According to Naeem et al.’s article, “Coping with Covid”, Cognitive Behavioral Therapy (CBT) is the ideal intervention tool to increase resilience. Their study has recently been published in "Kyber Medical University Journal". The authors investigate the psychological impact of the Covid-19…

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Early Life Factors for Endometriosis

Early Life Factors for Endometriosis By Dr. Youngran Park

Endometriosis affects approximately 10% of reproductive-aged women. Despite the significant impact, the etiology of endometriosis is still unclear. A recent systematic review of 15 studies of adolescents found that overall 65% of girls undergoing laparoscopic investigation were diagnosed with endometriosis.…

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Long-term Pregnancy Results after Surgical Removal of Endometrioma

Long-term Pregnancy Results after Surgical Removal of Endometrioma By Irem Onur

Sun et al., from China, investigated the pregnancy outcomes and the related factors in patients with endometrioma and stage III-IV endometriosis along with a long-term follow-up postoperatively. Their study has recently been published in the journal named "Advances in Therapy".…

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The Relationship Between Dyspareunia and Infertility in Endometriosis

The Relationship Between Dyspareunia and Infertility in Endometriosis By Selma Oransay

Wahl et al. from the Center of Pelvic Pain and Endometriosis British Columbia Women's Hospital, Vancouver, Canada studied with endometriotic patients suffering from dyspareunia who were referred to their center and built a cross-sectional study to investigate the relations between…

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Does Getting Pregnant Really Help When You Have Endometriosis?

Does Getting Pregnant Really Help When You Have Endometriosis? By Özge Özkaya

Pregnancy has a favorable impact on the volume of deep infiltrating endometriosis lesions according to a study published in the scientific journal "PLoS One". This is the first study that demonstrates such a favorable impact of pregnancy on endometriosis lesion…

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The predictive factors for early spontaneous miscarriage in IVF/ICSI cycles

The predictive factors for early spontaneous miscarriage in IVF/ICSI cycles By Hale Goksever Celik

The most common presenting complaints of endometriosis are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Affected women demand therapy for these symptoms of endometriosis, notably fertility problems. The clinical pregnancy rate has increased up to 60% in assisted reproductive…

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Regulation of Inflammation in Endometriosis

Regulation of Inflammation in Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent and multifaceted gynecological condition. Unfortunately, this disease frequently causes chronic and cyclic pelvic pain. Though there are several treatments are available, there is not an actual cure for this disease. Therefore, the development of new therapy…

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How well do providers understand endometriosis?

How well do providers understand endometriosis? By Demet Candaş Green

Endometriosis is a challenging disease no matter what side of the equation you are in, a patient or a provider who cares for patients with the disease. It impacts millions of women worldwide, making it one of the most prevalent…

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Primary care physicians have a crucial role in the early diagnosis of endometriosis

Primary care physicians have a crucial role in the early diagnosis of endometriosis By Nasuhi Engin Aydin

Dr. Verket and associates from the University of Oslo, Norway, published their cross-sectional anonymous postal questionnaire study in "BMJ open". Diagnosing endometriosis is difficult because dysmenorrhea, dyspareunia, and infertility are also common among other diseases. The most accurate and reliable diagnosis…

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Integrated bioinformatic analysis for endometriosis diagnosis

Integrated bioinformatic analysis for endometriosis diagnosis By Nadire Duru

Endometriosis is considered as a non-malignant disease, but it is associated with several unfavorable conditions including non‑menstrual pelvic pain and infertility. Surgical resection and hormone suppression are common means of treatments; however, several side-effects and the recurrence are not preventable.…

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The role of acidic ribosomal protein P1 in Endometriosis

The role of acidic ribosomal protein P1 in Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. The disease develops and composed of the ectopic endometrial-like tissue which establishes primarily in the pelvic cavity. Previous findings clearly show that estrogen-related factors are critical for endometriosis development and progression. However, we do have…

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The prevalence and severity of endometriosis today

The prevalence and severity of endometriosis today By Irem Onur

Ghiasi M. et al., a group of researchers from the USA, presented a comprehensive review of the prevalence, incidence, and stage of endometriosis worldwide as reported over the past 30 years. Researchers performed a search in four databases, including PubMed,…

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The association between endometriosis and ectopic pregnancy

The association between endometriosis and ectopic pregnancy By Hale Goksever Celik

Endometriosis is a chronic inflammatory disease with a broad spectrum of symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain and fertility problems. It has been understood in the light of scientific evidence that endometriosis is also associated with other poor…

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Endometriosis signaling: the role of IL-34

Endometriosis signaling: the role of IL-34 By Yu Yu

An increasing number of studies have suggested that the pathogenesis of endometriosis is mediated by cytokines, such as interleukin (IL)−17, which promoted the formation and progression of endometriosis by up-regulating angiogenesis and pro-inflammatory cytokines secretion. IL-34 is a newly described…

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How to design patient-centered interventions to meet the needs of endometriosis patients

How to design patient-centered interventions to meet the needs of endometriosis patients By Selma Oransay

The treatment of endometriosis is not perfect and necessitates the development of patient-oriented care initiatives. On this basis, patient-related transparent information should be the priority for researchers to find out a way for targeted interventions. Steele et al. from Australia and…

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When to do - and when not to do surgery for endometriosis

When to do - and when not to do surgery for endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. It was estimated to affect about 176 million women in the world and usually causes pelvic pain and infertility. Unfortunately, the current understanding of this disease is very limited. Though there are many remaining questions,…

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Recent advances in the diagnosis and treatment of endometriosis

Recent advances in the diagnosis and treatment of endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. The most common complaints of women with endometriosis are pain and fertility problems. Although many advanced types of research about the etiology, differential diagnosis and treatment have been…

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Surgery and the endometriosis associated-pain: A systematic review

Surgery and the endometriosis associated-pain: A systematic review By Selma Oransay

The surgical approach for pelvic pain-related to endometriosis depends on the stage and the type of the endometriotic lesion and ranging from ablation and the excision of the lesions to radical surgery as hysterectomy with removal of ovaries and presacral…

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Is deep infiltrating rectosigmoid endometriosis a progressive disease?

Is deep infiltrating rectosigmoid endometriosis a progressive disease? By Demet Candaş Green

This study by Netter at al., published in "Human Reproduction" in November 2019 aimed to assess the risk of progression of deep endometriotic nodules infiltrating the rectosigmoid and to evaluate the influence of continuous amenorrhoea (absence of menstruation) on the development…

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Risk of placenta previa is elevated in endometriotic women who underwent surgery.

Risk of placenta previa is elevated in endometriotic women who underwent surgery. By Selma Oransay

In the last decade concerns raised for surgical operations performed before pregnancies of endometriotic patients due to significantly increased risk of pregnancy complications such as placenta previa, preterm birth, hypertensive disorders of pregnancy, placental abruption, postpartum hemorrhage and small baby…

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Regret assessment in women under 35 years who underwent hysterectomy

Regret assessment in women under 35 years who underwent hysterectomy By Hale Goksever Celik

Hysterectomy is the most common gynecological operation in women for the management of benign or malign indications. Leiomyomas, menorrhagia, endometriosis, and pain unresponsive to medical treatment can be accepted as the most common indications for hysterectomy. However, hysterectomy, as the…

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Endometriosis features vs Patient age

Endometriosis features vs Patient age By Dr. Youngran Park

Endometriosis, a common gynecological disease, has significant negative impacts on patients’ daily life. Especially in younger women who have yet to achieve pregnancy, effective management should consider the disease progression. Though it is still under debate, some people suggest that…

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Cloverleaf Sign: A new MRI sign for diagnosing DIE

Cloverleaf Sign: A new MRI sign for diagnosing DIE By Selma Oransay

Magnetic resonance imaging provides accurate information for the staging of deeply infiltrating endometriosis, especially when the patient is virgin, obese or has limited transvaginal examinations due to pelvic pain. In this recently published study in Investive Radiology, Harma et al.…

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How Best to Assess Productivity at Work Among Women with Endometriosis?

How Best to Assess Productivity at Work Among Women with Endometriosis? By Özge Özkaya

The health-related productivity questionnaire (HRPQ) is a valid tool to evaluate patient-reported productivity at work and at home among women with endometriosis found a study by U.S. researchers.  This finding is important because it shows that HRPQ can be used…

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A new target for the treatment of endometriosis?

A new target for the treatment of endometriosis? By Dr. Youngran Park

Endometriosis affects around 10% of women in reproductive age, estimating more than 176 million women worldwide. Inflammation in the pelvic cavity is very common in endometriosis patients. Therefore, there are high concentrations of cytokines and immune cells in the peritoneal…

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M1 and M2 macrophages in ovarian endometriomas

M1 and M2 macrophages in ovarian endometriomas By Yu Yu

Macrophages play an essential role in the immune response during inflammation and have been implicated in diseases such as inflammatory conditions and cancers. Broadly, macrophages are classified into M1 and M2. The M1 macrophages are pro-inflammatory, and in contrast, the…

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Increased obstetrical complications after ART therapy in endometriosis patients.

Increased obstetrical complications after ART therapy in endometriosis patients. By Selma Oransay

To examine the impact of endometriosis and adenomyosis on ART therapy, Harada et al. from the Department of Obstetrics and Gynecology of Tottori University, Japan, planned a prospective cohort study and published their results recently in PLoS One.  The study…

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Serum anti-Müllerian hormone levels for predicting spontaneous pregnancy after endometriosis surgery

Serum anti-Müllerian hormone levels for predicting spontaneous pregnancy after endometriosis surgery By Hale Goksever Celik

Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Although there are several medical and surgical therapeutic options, the most effective treatment modality has not yet been elucidated.    The main…

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Endometriosis as an epigenetically regulated disease

Endometriosis as an epigenetically regulated disease By Dr. Youngran Park

Endometriosis is defined as the abnormal growth of endometrial tissue outside of the uterus. It affects about 10% of reproductive age women resulting in severe pain and infertility. Among various theories of endometriosis pathogenesis, not a single one has successfully…

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Consquences of endometriosis in menopausal period.

Consquences of endometriosis in menopausal period. By Selma Oransay

Marie-Scemama et al. from Foch Hospital, Suresnes, France, referred to endometriosis and menopause which is an actual cruising topic and recently published it in the journal named "Hormone Molecular Biology and Clinical Investigation". Endometriosis a well-known estrogen-dependent disease has three…

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New Protein for Endometriosis Diagnosis

New Protein for Endometriosis Diagnosis By Özge Özkaya

A protein called TIMP3 (tissue inhibitor of metalloproteinase-3) could be used for the diagnosis and prognosis (likely course) of endometriosis.  The early diagnosis of endometriosis is of paramount importance because it can help to diagnosis and thus initiate the right…

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How does pregnancy affect endometriosis?

How does pregnancy affect endometriosis? By Hale Goksever Celik

Endometriosis is the localization of endometrial stromal and glandular cells outside the uterine cavity. Pregnancy is offered as a treatment option for patients with endometriosis because it causes atrophy of endometrial cells similar to progesterone treatment. Progesterone predominance during pregnancy,…

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Endometriosis and the quality of life

Endometriosis and the quality of life By Selma Oransay

Recent developments of technics and improvement of skill in the laparoscopic field increased the courage of clinicians to attempt early and multiple diagnostic operations on endometriotic patients. Vanuccini et al. from NEUROFARBA, University of Florence, Florence, Italy recently published their…

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Melatonin receptors and their role in endometrial cell proliferation

Melatonin receptors and their role in endometrial cell proliferation  By Hale Goksever Celik

Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Despite extensive research, the exact pathophysiological mechanism and the optimal management of endometriosis still remains unclear. Management of endometriosis should aim to relieve pain,…

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The accuracy of "lower endoscopic ultrasound" for the preoperative diagnosis of rectosigmoid endometriosis

The accuracy of By Hale Goksever Celik

Endometriosis affects reproductive-aged women most frequently with a prevalence of 5% to 15%. If the endometriotic lesions involve the bowel especially sigmoid colon and rectum, this subtype of endometriosis is named as "bowel" or "rectosigmoid" endometriosis. Rectosigmoid endometriosis is encountered in…

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Pregnancy with endometriosis

Pregnancy with endometriosis By Demet Candaş Green

Current literature suggests that complications of endometriosis during pregnancy are rare; however, a non-negligible increase in the likelihood of placenta accreta (placenta grows too deeply into the uterine wall), preterm birth, and cesarean delivery has been reported. With the increase…

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Prescription Opioid Use in Women With Endometriosis

Prescription Opioid Use in Women With Endometriosis By Deniz Kocas

In this study, researchers examined opioid use, opioid prescribing patterns, and timing of the first opioid prescription in endometriosis patients compared with matched women in the control group without endometriosis. A retrospective analysis of Optum Clinformatics Data Mart was conducted.…

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Infertility in women with endometriosis

Infertility in women with endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. The most common presenting complaints are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Despite extensive research, the etiopathogenic mechanism underlying the two has not been fully elucidated. Although human…

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The Effect of Imbalanced Progesterone Receptors-A/B on Gelatinase Expressions in Endometriosis

The Effect of Imbalanced Progesterone Receptors-A/B on Gelatinase Expressions in Endometriosis By Dr. Youngran Park

Endometriosis is a benign disease which affects approximately 10% of reproductive-aged women and is one of the most common reasons for infertility. Though the underlying mechanisms of disease progression have not been clearly understood, it develops as a consequence of…

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Health care resource utilization and cost in women with endometriosis

Health care resource utilization and cost in women with endometriosis By Hale Goksever Celik

Endometriosis is a chronic inflammatory disease affecting 6-10% of reproductive-aged women. The clinical picture of the disease range from asymptomatic findings to dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Endometriosis has also complex etiopathogenetic background. This broad clinical spectrum, the…

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Importance of monocytic myeloid derived supressor cells in endometriosis

Importance of monocytic myeloid derived supressor cells in endometriosis By Nasuhi Engin Aydin

Myeloid-derived suppressor cells MDSCs are immature myeloid cells that play a major role in immunosuppression in various disease processes.  Ya Sun and associates have investigated these cells in endometriosis utilizing various laboratory methods. published their results in the "American Journal of…

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"Endometriosis", "Fibromyalgia" and "Autoimmune diseases"

By Irem Onur

Greenbaum et al. from Israel, investigated the prevalence of and the association between endometriosis, fibromyalgia and autoimmune diseases in a large population database and described healthcare resource utilization in affected women. Their study has been published in the "American Journal…

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Seven Hormonal Biomarkers for Diagnosing Endometriosis

Seven Hormonal Biomarkers for Diagnosing Endometriosis By Dr. Youngran Park

Endometriosis is an inflammatory condition characterized by implantation and invasive growth of endometrial tissue outside the uterine cavity. Although it is benign, endometriosis has cancer-like features, a mutation profile similar to that of ovarian cancer, and increased ovarian cancer risk.…

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The link between autoimmunity and endometriosis

The link between autoimmunity and endometriosis By Yu Yu

A popular model to explain the etiology of endometriosis is Sampson’s theory of retrograde menstruation. In this model, the viable endometrial tissue is spread and attached to the peritoneal cavity through the fallopian tubes during menstruation, resulting in an inflammatory…

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Searching new biomarkers for endometriosis

Searching new biomarkers for endometriosis By Selma Oransay

This recent article published in Advances in Clinical Chemistry, is an overall summary of characteristics, physiopathological theories, diagnostic approaches and variety of biomarkers to diagnose endometriosis and penned by Coutinho et al. from Universidade Federal de Juiz de Fora, Belo Horizonte,…

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The reason for lower BMI and less body fat in women with endometriosis.

The reason for lower BMI  and less body fat in women with endometriosis. By Selma Oransay

Zolbin et al. from the Department of Obstetrics and Gynecology of Yale School of Medicine, New Haven, USA, recently published the results of their prospective controlled research on adipocyte alterations in endometriosis, in the journal "Reproductive Biology and Endocrinology". Endometriosis can…

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Behavioral Symptoms in an Animal Model of Endometriosis

Behavioral Symptoms in an Animal Model of Endometriosis By Yu Yu

Recent studies suggest that there is a relationship between endometriosis and some behavioral symptoms. Prolonged pelvic pain and the other endometriosis symptoms can often affect psychological and social functioning, resulting in issues with social relationships, sexuality, and even mental health.…

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Proposed algorithm for a clinical diagnosis of endometriosis.

Proposed algorithm for a clinical diagnosis of endometriosis. By Selma Oransay

This recently published article in the American Journal of Obstetrics and Gynecology is about the challenge of diagnosing endometriosis, its impact on women's daily life and authored by Agarwal et al. from The University of California, San Diego, CA, USA. Authors called attention…

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The postoperative functional outcomes of deep infiltrating endometriosis

The postoperative functional outcomes of deep infiltrating endometriosis By Hale Goksever Celik

Rectosigmoid endometriosis is defined as the infiltration of the bowel wall with the endometrial-like glands and stroma, reaching at least the muscular layer. The most commonly involved sites are the rectum and sigmoid colon. For the management of deep infiltrating…

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A new trial to reduce the failure of IVF/ICS protocols in severe endometriosis

A new trial to reduce the failure of IVF/ICS protocols in severe endometriosis By Selma Oransay

Kong et al., from the first affiliated hospital of Zhengzhou University, China, recently published this single-blinded, a multicentered and randomized controlled study in the Journal of Reproductive Health, with the aim to find a safer and more effective ovulation induction regimen for patients with…

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Endometriosis and nuclear receptors

Endometriosis and nuclear receptors By Dr. Youngran Park

It is well recognized that endometriosis is a steroid-dependent disorder. In endometrial stromal cells, progesterone regulates retinoic acid production and action. Retinoids also act via a number of nuclear receptors (NRs) and are involved in normal endometrial function and endometriosis. Estrogen…

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Ovarian stimulation regimes: Concerns on progression or recurrence of endometriosis

 Ovarian stimulation regimes: Concerns on progression or recurrence of endometriosis By Selma Oransay

Somigliana et al., from the University of Milan, Italy, performed a literature review to predict the endometriosis-enhancing effect of ART regimes on infertile women and reported their results in Reproductive Biomedicine Online. Their points of interest were increasing dysmenorrhea, dyspareunia, non-menstrual pain and…

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Preoperative factors to predict unresponsiveness in women undergoing endometriosis surgery

Preoperative factors to predict unresponsiveness in women undergoing endometriosis surgery By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Despite extensive research, the optimal management of endometriosis still remains unclear. Several treatment options include analgesic medication, hormonal treatments, and surgical intervention. There is…

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Nutraceuticals may help for endometriosis pain

Nutraceuticals may help for endometriosis pain By Nasuhi Engin Aydin

 Dysmenorrhea and chronic pelvic pain occur in endometriosis patients in a significant percentage. Anti-inflammatory medications and lifestyle changes including diet form the integrated approach in this regard. However, the medications can be used only for the short term. Natural substances with anti-inflammatory…

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Estrogen Receptor Signaling and Endometriosis-Associated Ovarian Cancer

Estrogen Receptor Signaling and Endometriosis-Associated Ovarian Cancer By Selma Oransay

Andersen et al. published a prospective cohort study in the Journal of Hormones and Cancer to enlighten the estrogen signaling pathway during the transition from endometriosis to endometriosis-associated ovarian cancer. Given the shared pathway of endometriosis and ovarian cancer as…

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Factors Affecting Women’s Choices to Enter Clinical Trials

Factors Affecting Women’s Choices to Enter Clinical Trials By Özge Özkaya

Women were strongly influenced by their previous experiences and personal circumstances when deciding to take part in a clinical trial. This is based on the findings of a study published in the journal Pilot and Feasibility Studies that explored the…

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Immunologic Disorder in the Progression of Endometriosis

Immunologic Disorder in the Progression of Endometriosis By Dr. Youngran Park

Endometriosis becomes increasingly a health-social problem. However, definite diagnostic biomarkers and more effective treatments for endometriosis are still missing to this day.  Many researchers focus on the peritoneal microenvironment of patients with endometriosis, especially the immunological microenvironment. Recently, Jørgensen et…

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The miscarriage rate in women with endometriosis undergoing IVF fresh cycles

The miscarriage rate in women with endometriosis undergoing IVF fresh cycles By Hale Goksever Celik

Endometriosis is a chronic estrogen-dependent disease diagnosed in 25-40% of women with infertility. There are several mechanisms explaining the negative impacts of endometriosis on fertility through the entire reproductive process such as sperm-oocyte interaction, ovarian reserve, and implantation. Endometriosis is…

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A link between endometrioid ovarian carcinoma and endometriosis.

A link between endometrioid ovarian carcinoma and endometriosis. By Selma Oransay

Ciavattini et al.from Polytechnic University Ancona, Italy create a pilot study which recently published in Oncology Letters to clarify the link between endometriosis and endometrioid ovarian cancer. The unfolded protein response (UPR) activity as a promoter of neoplastic progression of malignancies is…

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Which comes first in endometriosis management: In vitro fertilization or surgery?

Which comes first in endometriosis management: In vitro fertilization or surgery? By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence is found to be 7%–10%, but among infertile women, it increases up to 50%. Early diagnosis and personalized management are important to…

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Endometrioma, Fertility, and Assisted Reproduction

Endometrioma, Fertility, and Assisted Reproduction By Dr. Youngran Park

Endometriosis can negatively impact a woman’s health and quality of life. Surgery has been considered the primary treatment to overcome infertility in cases of ovarian endometrioma. Patients struggling with endometriosis often pursue assisted reproductive technologies (ART) due to fertility issues.…

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Assistive Reproduction a Suitable Option for the Treatment of Endometriosis-Associated Infertility

Assistive Reproduction a Suitable Option for the Treatment of Endometriosis-Associated Infertility By Özge Özkaya

Assistive reproductive techniques do not lead to a worsening in quality of life and only cause a slight worsening of pelvic pain, according to a study published in the scientific journal Acta Obstetricia et Gynecologica Scandinavica. This is the case…

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The association between the development of endometriosis and dietary habits

The association between the development of endometriosis and dietary habits By Hale Goksever Celik

Endometriosis is a chronic disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence is found to be approximately 10% in the general population. Endometriosis is associated with infertility, pelvic pain, and increased…

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Bowel endometriosis: What you need to know

Bowel endometriosis: What you need to know By Demet Candaş Green

When the endometrial tissue infiltrates the intestinal walls and reaches inside the intestines, this condition is called "bowel endometriosis". It is estimated that between 3.8% and 37% of women with endometriosis are affected by bowel endometriosis. The endometriosis lesions infiltrating…

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Endometriosis and female pelvic pain in all aspects

Endometriosis and female pelvic pain in all aspects By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence of the disease ranges between 6-10% in reproductive-aged women. However, endometriosis is more frequently encountered in women with chronic pelvic pain and…

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Mistletoe as a Potential Candidate for Endometriosis Treatment

Mistletoe as a Potential Candidate for Endometriosis Treatment By Dr. Youngran Park

Endometriosis, one of the common benign gynecologic disorders, is defined as the ectopic presence of endometrial cells outside of the uterine cavity. Although the underlying mechanisms are not fully understood, the most accepted hypothesis is that endometrial cells pass through…

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Surgical techniques for rectosigmoid endometriosis, and functional outcomes

Surgical techniques for rectosigmoid endometriosis, and functional outcomes By Hale Goksever Celik

Rectosigmoid endometriosis is defined as the infiltration of bowel wall with the endometrial-like glands and stroma, reaching at least the muscular layer. Rectosigmoid endometriosis is encountered in approximately 8-12% of patients with a diagnosis of endometriosis. The most commonly involved…

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Development of Less Invasive Diagnostic Tests for Endometriosis Through Proteomics

Development of Less Invasive Diagnostic Tests for Endometriosis Through Proteomics By Murat Osman

Proteomics is a field which utilizes various methods to carry out large-scale studies of proteins. Due to the inherent nature of the field, proteomics focuses on the identification, localization, and functional analysis of the protein make-up of a given type…

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Is the mystery for progression of endometriosis hiding out in abnormally located endometrial cells?

Is the mystery for  progression of endometriosis hiding out in abnormally located endometrial cells? By Selma Oransay

This prospective study was conducted by Hapangama et al. in Research İnstute of the University of Liverpool, UK, and the results have recently published in the Journal of Human Reproduction. The authors hypothesized that abnormally located endometrial basalis-like (SSEA1/nSOX9+)cells could be contributing to…

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The role of circulating microRNA's in Endometriosis

The role of circulating microRNA's in Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. This disease affects approximately 10% of reproductive-aged women and 20% to 50% of infertile women. Steroidogenic factor 1 (SF-1) is an essential transcriptional regulator coordinately regulating multiple genes involved in estrogen biosynthesis. SF-1 is known…

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Factors related to delay in endometriosis diagnosis

Factors related to delay in endometriosis diagnosis By Nasuhi Engin Aydin

Dr. Moniek van der Zanden, a gynecologist from Netherlands has recently made a nationwide survey on the impact of key recommendations of the European Society of Human Reproduction and Embryology (ESHRE) guidelines on endometriosis and aimed to assess factors influencing diagnostic delay of…

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Lipophilic Statins inhibit growth and invasiveness of human endometrial cells

Lipophilic Statins inhibit growth and invasiveness of human endometrial cells By Murat Osman

Endometriosis is a disease process whereby cells of the endometrium grow and invade structures outside of the uterus. Through recent research, it has been seen that endometriotic foci in women with endometriosis exhibit an altered phenotype that contributes to its…

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What clinicians know about adenomyosis? Any association with severe endometriosis?

What clinicians know about adenomyosis? Any association with severe endometriosis? By Selma Oransay

Dior et al. from the Royal Women's Hospital in Parkville, Australia, designed a prospective study to assess the association between severity of endometriosis and sonographic evidence of adenomyosis (SEOA) in their recently published article appearing in The Journal of Minimally…

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Anti-proliferative and anti-inflammatory effects of "Quercetin" on endometriosis

 Anti-proliferative and anti-inflammatory effects of By Dr. Youngran Park

Quercetin is a major flavonol that is mainly derived from capers and involves a daily consumption of approximately 25–50 mg through various vegetables. In recent studies, Quercetin is reported as a functional compound in obesity, diabetes and cardiovascular diseases. This compound…

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Not True That Women With Endometriosis Can’t Conceive

Not True That Women With Endometriosis Can’t Conceive By Özge Özkaya

The common assertion that women with endometriosis are unlikely to conceive is countered by a new study published in The European Journal of Contraception & Reproductive Health Care. This finding supports the need for healthcare and information to address all…

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Progesterone Receptor Status in Endometriosis

Progesterone Receptor Status in Endometriosis By Serdar Balci

Some patients do not respond to progesterone hormone therapy. In this study recently published in the Journal of Clinical Endocrinology and Metabolism, the authors led by Hugh S. Taylor from the Department of Obstetrics, Gynecology and Reproductive Sciences from Yale…

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Programmed-cell death pathway and immune dysfunction in endometriosis

Programmed-cell death pathway and immune dysfunction in endometriosis By Irem Onur

Endometriosis is an estrogen-dependent, immune-associated disease. Women with endometriosis have different proportions of the activated forms of immunocompetent cells, such as T cells and macrophages compared to those from women without. Immune cell dysfunction in the uterine and abdominal cavity…

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How to predict natural conception in women underwent endometriosis surgery?

How to predict natural conception in women underwent endometriosis surgery? By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The most common symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. The prevalence of endometriosis increases in the infertile population. Thus, the important…

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An overlooked symptom of endometriosis: Fatigue

An overlooked symptom of endometriosis: Fatigue By Timur Seckin

A majority of endometriosis patients experience fatigue. This is according to a multicenter study conducted by a group of researchers from Switzerland, Germany, and Austria. Fatigue, and feeling spoonie, may be a symptom of endometriosis affecting the daily activities and…

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Is Physical Exercise Effective in Endometriosis?

Is Physical Exercise Effective in Endometriosis? By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial tissue outside the uterine cavity. Dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility are mostly encountered symptoms of endometriosis. Although there are several theories explaining the pathogenesis of endometriosis, the exact pathogenesis still has…

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The diagnosis and management of endometriosis in Korea

The diagnosis and management of endometriosis in Korea By Selma Oransay

The Korean Society of Endometriosis has scrutinized the present published literature of endometriosis in the domestic and international platform to provide new guidelines and the clinical management of the disease. The study was recently published in the journal "Obstetrics and Gynecology…

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Autophagy, proteolysis and Endometriosis

Autophagy, proteolysis and Endometriosis By Kasthuri Nair

Sui et al., a group of researchers from the Qiqihar Medical University and Qilu Hospital of Shandong University, recently published in Experimental and Therapeutic Medicine. The piece titled “Expression and significance of autophagy genes LC3, Beclin1 and MMP-2 in endometriosis”…

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Best endometriosis articles of the past year.

Best endometriosis articles of the past year.  By Selma Oransay

Dr.Stowall, from the Department of Obstetrics and Gynecology of Methodist Hospital, Dallas, Texas, USA penned this letter and recently published it in the Journal of Obstetrics and Gynecology to show his remarks of importance on four best publications of the…

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Programmed cell death 4 suppresses endometriosis by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway

Programmed cell death 4 suppresses endometriosis by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway By Dr. Youngran Park

Endometriosis is a kind of benign disease but shares many similar features with cancers, such as abnormal cell migration, invasion, and unrestrained growth. It has been known that some genes are expressed differentially in eutopic endometrium of EM patients compared…

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How Ovarian Endometriomas and DIE affect ART outcomes

How Ovarian Endometriomas and DIE affect ART outcomes By Murat Osman

Previous studies have evaluated the impact of an ovarian endometrioma on ovarian reserve and its impact on the success of assisted reproductive technology (ART) outcomes have controversial results.  ART is a method by which a woman’s own hormones are used…

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Will Getting Pregnant Make My Pain Go Away?

Will Getting Pregnant Make My Pain Go Away? By Özge Özkaya

Pregnancy can relieve the symptoms of endometriosis, according to a new study published in the European Journal of Obstetrics & Gynecology and Reproductive Biology. However, for most women, the pain usually returns like in the case of hormonal therapy. This…

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Maternal and fetal outcomes in women with endometriosis : A review and meta-analysis

Maternal and fetal outcomes in women with endometriosis : A review and meta-analysis By Selma Oransay

Lalani et al from Dept. of Obstet. and Gynecol. , University of Ottowa, Canada, recently published this systemic review and meta-analysis of observational studies in the Journal of Human Reproduction, aimed to present the difference in the maternal and fetal…

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Non-assisted reproductive technology treatment: Is it effective in infertile patients with advanced endometriosis?

Non-assisted reproductive technology treatment: Is it effective in infertile patients with advanced endometriosis? By Hale Goksever Celik

The marriage and childbearing ages delay due to the life-style changes in developed countries. As a result, advanced age becomes a major concern in infertility treatments which consist of non-ART and ART modalities. Non-ART treatments include mild ovarian stimulation together…

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PROPOFOL: a new combat for endometriosis?

PROPOFOL: a new combat for endometriosis? By Selma Oransay

Feng et al, from the Department of  Gynecology Weifang Medical University Hospital, Shandong, China, recently published their prospective experimental research in the journal Experimental and Therapeutic Medicine. Propofol, a rapid and short-term anesthetic substance, recently has been shown to prevent cancer through inhibiting…

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Quality of life for women with endometriosis

Quality of life for women with endometriosis By Irem Onur

Endometriosis symptoms may cause difficulties in daily activities and social life, altering general health and personal relationships and severely decrease the quality of life. Yoldemir T. evaluates the factors affecting the quality of life in endometriosis patients and the management strategies in…

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How to preserve fertility in women with “ovarian endometriosis”?

How to preserve fertility in women with “ovarian endometriosis”? By Hale Goksever Celik

Although there are many treatment modalities in endometriosis, optimal treatment has not been developed yet. The aim of the treatment is to reduce pain, to preserve and improve fertility and to delay recurrence. Ovarian ischemic and perfusion damage during endometriosis…

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Shedding light on the fertility preservation debate in women with endometriosis: a swot analysis.

Shedding light on the fertility preservation debate in women with endometriosis: a swot analysis. By Deniz Kocas

There is little known about fertility preservation in women with endometriosis. Researchers from France and Switzerland conducted a SWOT (strengths, weaknesses, opportunities, and threats) analysis to better understand this topic. Applied to clinical problems, SWOT gives a thorough analysis of…

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Cosmetics and some household products could be responsible for worsening endometriosis.

Cosmetics and some household products could be responsible for worsening endometriosis. By Selma Oransay

A controlled clinical study recently published in the Journal of Human Reproductive Sciences,  composed by Nazir et al. from the University of Health Sciences, Lahore, Pakistan. The study compared the blood diethyl hexyl phthalate (DEHP) levels of fifty infertile women laparoscopically diagnosed…

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Transvaginal ultrasound for "rectosigmoid endometriosis" diagnosis: Is bowel preparation necessary?

Transvaginal ultrasound for By Hale Goksever Celik

Rectosigmoid endometriosis is a severe form of deep endometriosis. Women having rectosigmoid endometriosis present with pain and several intestinal complains such as constipation, diarrhea, intestinal cramping, abdominal bloating, feeling of incomplete evacuation, the passage of mucus and rectal bleeding during…

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IVF Is the Best Option to Become Pregnant for Women with Severe Endometriosis, or Is It Not?

IVF Is the Best Option to Become Pregnant for Women with Severe Endometriosis, or Is It Not? By Özge Özkaya

Treating rectal endometriosis with surgery seems to increase the chance of a woman conceiving, with most pregnancies occurring naturally. This is according to a study published in the medical journal Human Reproduction.  The optimal treatment for women with severe endometriosis…

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Endometriosis in adolescents

Endometriosis in adolescents By Irem Onur

Dr. Mama S. T. from Cooper University Hospital, Camden, New Jersey, USA, recently has published his review on advances in the management of endometriosis in the adolescent in the journal “Current Opinion Obstetrics and Gynecology”. In adolescence, there is a…

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A Balancing Act: How Endometriosis Invades the Body

A Balancing Act: How Endometriosis Invades the Body By Murat Osman

Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterine cavity. Ectopic endometrial tissues have been shown to have some features that mimic malignancy. For example, endometriosis can invade surrounding structures and attach to surfaces such…

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The vaginal delivery rate of singleton term pregnancies still remains the same after total deep infiltrating endometrosis excisions

The vaginal delivery rate of singleton term pregnancies still remains the same after total deep infiltrating endometrosis excisions By Selma Oransay

This recently published report in the Journal of Fertility Sterility is planned as a  matched case-control study, by Nirgianakanis et al. from the University of Bern, Switzerland. Authors claimed their study is the first because previous studies on pregnancy outcome after laparoscopic…

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Prior endometriosis surgery and the risk of pregnancy complications

Prior endometriosis surgery and the risk of pregnancy complications By Irem Onur

Koninckx et al. discussed the association of pregnancy complications with endometriosis and endometriosis surgery in their recently published paper in the journal Fertility and Sterility. They especially mentioned about the retrospective study of Nirgianakis et al. published in the same…

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GnRH Analogues Not Beneficial For Superovulation and Intrauterine Insemination

GnRH Analogues Not Beneficial For Superovulation and Intrauterine Insemination By Kasthuri Nair

Bansal et al, a group of authors from the All India Institute of Medical Sciences, recently published a paper titled “The Role of GnRH Analogues in Improving Outcome in Women Undergoing Superovulation and Intrauterine Insemination after Surgical Correction of Mild…

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Impact of coping strategies on quality of life of adolescents and young women with endometriosis.

Impact of coping strategies on quality of life of adolescents and young women with endometriosis. By Deniz Kocas

González-Echevarría et al. report in J Psychosom Obstet Gynaecol. that symptoms caused by endometriosis have been found to be associated with negative quality of life (QoL) in women with endometriosis and the type of coping strategies adopted by patients have been shown…

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Could the Sleep Hormone Treat Endometriosis?

Could the Sleep Hormone Treat Endometriosis? By Özge Özkaya

Melatonin blocks cell proliferation, invasion, and migration in both normal and endometriotic epithelial cells, according to a study published in the scientific journal Reproductive Biology and Endocrinology. Melatonin could, therefore, be a potential treatment for endometriosis  The formation and progression…

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Adrenomedullin: The Pervasive Peptide

Adrenomedullin: The Pervasive Peptide By Kasthuri Nair

Dr. Aboulghar, from the Cairo University, recently penned an article titled “Role of adrenomedullin in reproduction and endometriosis” that was published in Fertility and Sterility. This article looks at the function of Adrenomedullin (AM) in pregnancy and endometriosis and it…

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Endometriosis Development: Pathogenesis and genomics

Endometriosis Development: Pathogenesis and genomics By Selma Oransay

In this review recently published in the International Journal of Molecular Sciences, Baranow et al from Saint Petersburg, Russia,  hypothesize the existence of an endometriosis development genetic program (EMDP) that governs the origin of endometrium stem cells programmed for endometriosis; their transition…

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The association between endometriosis, adenomyosis and preterm delivery

The association between endometriosis, adenomyosis and preterm delivery By Hale Goksever Celik

Endometriosis and adenomyosis are diseases of the same spectrum which have common features and coexist in some but not all patients. Both diseases are characterized by endometrial implants outside of the uterine cavity. Endometriosis is defined as the localization of…

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Polymorphism of IL12B May Help Solve Endometriosis

Polymorphism of IL12B May Help Solve Endometriosis By Kasthuri Nair

Zhao et al. recently published a paper titled “A functional promoter polymorphism in interleukin 12B gene is associated with an increased risk of ovarian endometriosis” in Gene. The research group from Hebei Medical University wanted to explore the potential roles…

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Pain catastrophizing, perceived injustice, and pain intensity impair life satisfaction

Pain catastrophizing, perceived injustice, and pain intensity impair life satisfaction By Deniz Kocas

Cognitive appraisals have been shown to have an effect on the experience of pain. Notably, perceived injustice and pain catastrophizing have been shown to play a role, but are rarely examined together. In addition, variability in appraisal processes has been…

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Is there a definitive guideline for the surgical management of endometriosis?

Is there a definitive guideline for the surgical management of endometriosis? By Murat Osman

Endometriosis is a chronic inflammatory disease that is defined by the presence of ectopic endometrial tissue outside of the uterus. Unfortunately, endometriosis continues to be a leading cause of chronic pelvic pain in women of reproductive age. This article titled,…

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Predictors of psychological distress

Predictors of psychological distress By Deniz Kocas

Studies have now established that endometriosis can negatively impact mental health and quality of life, however, some studies show that not all women with endometriosis are necessarily more distressed than healthy women. This suggests that individual differences may explain women’s’…

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Key to Understanding Ovarian Endometriosis may lay in the Peptides

Key to Understanding Ovarian Endometriosis may lay in the Peptides By Kasthuri Nair

Xue et al. recently published a paper titled “Peptidomic Analysis of Endometrial Tissue from Patients with Ovarian Endometriosis” in Cellular Physiology and Biochemistry. The research group from various departments of Nanjing Medical University wished to better understand the pathogenesis of…

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Oral Contraceptives and Low-Cost Progestins to Reduce Endometriosis-Associated Pain

Oral Contraceptives and Low-Cost Progestins to Reduce Endometriosis-Associated Pain By Özge Özkaya

Most women with endometriosis-associated pain did not feel the need to use expensive progestin or undergo surgery. Instead, they were satisfied with a low-cost progestin to treat their symptoms. This is according to a study published in the journal Fertility…

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Effectiveness of the Endometriosis Symptom Diary

Effectiveness of the Endometriosis Symptom Diary By Kasthuri Nair

Seitz et al., a research group from Bayer AG and the University of Giessen, recently published an article titled “Patterns of missing data in the use of the endometriosis symptom diary” in BMC Women's Health. The authors were analyzing data…

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Elevated levels of adrenomedullin in eutopic endometrium and plasma from women with endometriosis.

Elevated levels of adrenomedullin in eutopic endometrium and plasma from women with endometriosis. By Dr. Youngran Park

Endometriosis is a common gynecologic disease characterized by the presence of endometrial tissue outside of the eutopic endometrium, commonly in the peritoneum of the pelvis and in pelvic organs, and often causing scarring and pain. The nonspecific nature of endometriosis…

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Altered Immunity in Endometriosis

Altered Immunity in Endometriosis By Yu Yu

In recent years, there has been increased attention on the role of immune system in endometriosis development. Normally, immune reactions are supposed to destroy endometrial cells seeding in the peritoneal cavity. Nonetheless, in endometriosis, these cells are able to evade,…

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Ambiguous experience: Destructive or Constructive

Ambiguous experience: Destructive or Constructive By Deniz Kocas

A diagnostic delay of 4-12 years is reported among women with endometriosis, which is explained by the lack of awareness of endometriosis as a medical condition among patients and healthcare professionals. In searching for a diagnosis, patients encounter many healthcare…

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Will my Endometriosis Respond to Hormone Therapy?

Will my Endometriosis Respond to Hormone Therapy? By Özge Özkaya

Every woman has a different set of hormone receptors in the lining of their uterus. Yet, hormone-based therapies that are used to treat women with endometriosis do not take into consideration these differences among patients. Analyzing, which particular hormone receptors…

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How Artificial Intelligence Can Improve Our Understanding of the Genes Associated with Endometriosis.

How Artificial Intelligence Can Improve Our Understanding of the Genes Associated with Endometriosis. By Dr. Youngran Park

Endometriosis is a disease characterized by the development of endometrial tissue outside the uterus. A number of studies have shown that endometriosis could have a genetic basis and numerous genes have been studied and proposed to help explain its pathogenesis.…

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Animal models of endometriosis

Animal models of endometriosis By Yu Yu

For advancing understanding and treatment of endometriosis, The World Endometriosis Society has previously brought together researchers and clinicians to discuss the many important research priorities. One of these was the recommendation to development and building on the use of animal…

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Therapeutic strategies involving uterine stem cells in reproductive medicine

Therapeutic strategies involving uterine stem cells in reproductive medicine By Murat Osman

Stem cells are undifferentiated cells that often serve to regenerate tissue in states of injury or apoptosis. The endometrium has progenitor cells that replace tissue lost after each menstrual cycle. It has been postulated that excessive stem cell recruitment to…

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Non-coding RNAs in endometriosis

Non-coding RNAs in endometriosis By Dr. Youngran Park

The pathophysiological mechanisms causing the development of endometriosis, which is a heterogeneous disease remain enigmatic, and a lack of effective biomarkers necessitates surgical intervention for diagnosis. Non-coding RNA (ncRNA) molecules, which are important regulators of cellular function, have been implicated…

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Is the Endometriosis Fertility Index Reliable?

Is the Endometriosis Fertility Index Reliable? By Kasthuri Nair

Zhang et al. recently published a paper titled “Prediction of Endometriosis Fertility Index in patients with endometriosis-associated infertility after laparoscopic treatment” in Reproductive BioMedicine Online. The research group from the West China Second University Hospital in Sichuan University wanted to…

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Could Endometriosis Be Caused by Bacteria?

Could Endometriosis Be Caused by Bacteria? By Özge Özkaya

A new concept called the bacterial contamination hypothesis in endometriosis has been proposed for the first time by researchers in Japan. This means that new potential therapies approaches could exist for this condition in addition to the conventional estrogen-suppressing therapies.…

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Extending the Female Fertility Clock

Extending the Female Fertility Clock By Kasthuri Nair

Varela, Sanchez-de-Puerta, and Garcia-Velasco are a group of scientists from various institutions in Spain and they recently published a review article titled “Fertility, IVF and reproductive genetics” in Current Opinion in Obstetrics and Gynecology. In this publication, the authors discussed…

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Increasing IVF Success Rates

Increasing IVF Success Rates  By Özge Özkaya

DuoStim or double ovarian stimulation is the most promising approach to increase the number of eggs collected to be used in IVF, according to a review article published in the journal Current Opinion in Obstetrics and Gynecology.  Pain and infertility…

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Endometriosis surgery and preservation of fertility, what surgeons should know

Endometriosis surgery and preservation of fertility, what surgeons should know By Murat Osman

Endometriosis can involve most of the pelvic organs including the uterus, ovaries and fallopian tubes and thus has the potential to cause infertility. This article titled, “Endometriosis surgery and preservation of fertility, what surgeons should know” written by H. Roman…

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Stem cell therapy for the premature ovarian failure 

Stem cell therapy for the premature ovarian failure  By Dr. Youngran Park

Premature ovarian failure (POF) is one of the common disorders found in women. The cause of POF is not fully known, but various factors have been suggested. In genetically, X and autosomes chromosome abnormalities could result in some POF. The…

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Most Effective Embryo Transfer Strategy

Most Effective Embryo Transfer Strategy By Kasthuri Nair

Bourdon et al., a group of scientists mainly from the Centre Hospitalier Universitaire, recently published a paper in PLOS ONE titled “The deferred embryo transfer strategy improves cumulative pregnancy rates in endometriosis-related infertility: A retrospective matched cohort study.” This study…

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Reproductive delay and social egg freezing

Reproductive delay and social egg freezing By Yu Yu

The data collected from Office for National Statistics in England and Wales has suggested a major shift in the timing of motherhood. In the mid-1970s, the average age of motherhood was 26.4 years of age to, while in 2016, it…

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Endometriosis From an Epigenetic Lens

Endometriosis From an Epigenetic Lens By Kasthuri Nair

Samadieh et al. from the Royan Institute for Reproductive Biomedicine, recently published an article in Reproductive Sciences titled “Epigenetic Dynamics of HOXA10 Gene in Infertile Women With Endometriosis.” In this paper, the researchers wanted to observe HOXA10 gene expression in…

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Treatment of Endometriosis in Adolescents

Treatment of Endometriosis in Adolescents By Özge Özkaya

Most women with endometriosis who have been treated with Lupron plus add back as adolescents felt the treatment was effective in reducing the pain caused by the condition, according to a study published in the Journal of Pediatric & Adolescent…

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Endometrial stem cells and Endometriosis

Endometrial stem cells and Endometriosis By Dr. Youngran Park

Human endometrium is a cyclically proliferative tissue, and this monthly regeneration is likely mediated by endometrial stem (or progenitor) cells.The upper functional layer of the endometrium breaks down and is shed into the uterine cavity during menstruation. Re-epithelialization and repair…

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An Unusual Case "Free Floating Omental Endometrioma"

An Unusual Case By Kasthuri Nair

Capaccione et al. published an article in Radiology Case Reports titled “Massive endometrioma presenting with dyspnea and abdominal symptoms.” This publication is centered around a particularly unique case report of a woman who was ultimately diagnosed with endometriosis. The patient…

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The Chance of Getting Pregnant of a Woman with Endometriosis May Soon Be Predictable

The Chance of Getting Pregnant  of a Woman with Endometriosis May Soon Be Predictable By Özge Özkaya

Researchers have found a new way of predicting whether or not an embryo will be able to successfully implant into the womb of a woman with endometriosis. These findings could make it possible to predict whether she is likely to…

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Ectopic Pregnancy Risk Factors

Ectopic Pregnancy Risk Factors By Kasthuri Nair

Jacob, Kalder, and Kostev recently published an article titled “Risk factors for ectopic pregnancy in Germany: a retrospective study of 100,197 patients” in German Medical Science. The retrospective German study hoped to elucidate the risk factors for ectopic pregnancies. The…

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Potential New Target to Treat Endometriosis?

Potential New Target to Treat Endometriosis? By Özge Özkaya

Special cells called myeloid-derived suppressor cells (MDSC) could be playing a role in the development of endometriosis, suggests a study published in the European Journal of Immunology.  These cells could, therefore, be targeted by novel therapeutic agents to treat endometriosis. …

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Blood vessels formation in endometriosis

Blood vessels formation in endometriosis By Yu Yu

The endometrium undergoes dynamic changes during the menstrual cycle. Estrogen-driven angiogenesis is associated with the proliferative phase, and progesterone-driven vascular maturation occurs in the secretory phase. Hence, it is reasonable that the vascularization of endometriosis is also under complex regulation…

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Can Getting Pregnant Make my Pain Go Away?

Can Getting Pregnant Make my Pain Go Away? By Özge Özkaya

The association between pregnancy and symptoms of endometriosis are controversial and strongly biased, and there is no evidence suggesting that pregnancy reduces the size and number of endometriotic lesions, according to a study published in the journal Human Reproduction Update.…

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Switching to a Low-Cost Progestin May Help Reduce Endo Pain When Oral Contraceptives Won’t Work

Switching to a Low-Cost Progestin May Help Reduce Endo Pain When Oral Contraceptives Won’t Work By Özge Özkaya

The majority of women with endometriosis-associated pain were satisfied to have switched to a treatment with norethisterone acetate or NETA, a synthetic, orally active progestin, when their oral contraceptive was ineffective, found a study published in the journal Reproductive Sciences.…

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Endometriosis “Changes” the Brain

Endometriosis “Changes” the Brain By Özge Özkaya

Endometriosis changes the electrical properties of the brain as well as gene expression, according to a study by Yale researchers. These changes increase sensitivity to pain, anxiety, and depression. “While medications can be used to treat endometriosis directly, the effects…

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The effect of anti-rheumatic drugs on endometriosis therapeutic outcomes

The effect of anti-rheumatic drugs on endometriosis therapeutic outcomes By Yu Yu

Endometriosis can be described as an autoimmune disease because the abnormalities associated with T and B cell function and various autoantibodies. Although endometriosis has not been found to associate with some severe autoimmune disorders such as systemic lupus erythematosus, it…

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Are there any risk factor associated with the progression of endometriosis to ovarian cancer?

Are there any risk factor associated with the progression of endometriosis to ovarian cancer? By Murat Osman

Endometriosis is a disease whereby endometrial glands proliferate outside of the endometrial lining. Apart from causing significant morbidity, It has been found that endometriosis is associated with an increased risk of progression to endometroid and clear cell ovarian cancer. However,…

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Is the presence of endometriosis associated with a survival benefit in pure ovarian clear cell carcinoma?

Is the presence of endometriosis associated with a survival benefit in pure ovarian clear cell carcinoma? By Dr. Youngran Park

Ovarian clear cell carcinoma (OCCC) has been known to be associated with endometriosis for a long time. However, the impact of the presence of endometriosis around the tumor on the prognoses of women with OCCC is still controversial. To shed…

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Reason Why Hormone Therapy Alone Cannot Cure Endometriosis Uncovered

Reason Why Hormone Therapy Alone Cannot Cure Endometriosis Uncovered By Özge Özkaya

Researchers in Belgium have shed light on why hormone therapy cannot cure endometriosis on its own in a study published in the scientific journal Gynecological Endocrinology.  Their findings could shape the direction of future research and may help to find…

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Endometriosis Not a Risk for Pregnancy

Endometriosis Not a Risk for Pregnancy By Özge Özkaya

Women with endometriosis do not seem to be more at risk of having pregnancy-related complications compared to those without endometriosis, according to a study published in the Italian scientific journal Minerva Ginecologica. However, the authors say that larger studies are…

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Deep endometriosis and pregnancy

Deep endometriosis and pregnancy By Yu Yu

Several previous studies have investigated whether endometriosis can affect the normal development of pregnancy, although the results have been controversial. The aim of this review article by Leone Roberti Maggiore et al. is to provide an updated overview of health…

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The effect of endometriosis on preterm birth risk

The effect of endometriosis on preterm birth risk By Demet Candaş Green

Some studies show that women with endometriosis develop significant complications during pregnancy that lead to preterm labor, and newborns of these women often need neonatal intensive care unit admissions. However, other studies argue that endometriosis have no significant effect on…

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A Potential New Target for the Treatment of Endometriosis

A Potential New Target for the Treatment of Endometriosis By Özge Özkaya

A protein called STIP1 could be facilitating the migration of endometrial tissue outside the uterus, therefore, leading to endometriosis according to a study by Taiwanese researchers. The protein could, thus, be used as a potential therapeutic target for endometriosis.  For…

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The Use of Resveratrol as an Adjuvant Treatment of Pain in Endometriosis

The Use of Resveratrol as an Adjuvant Treatment of Pain in Endometriosis By Dr. Youngran Park

Endometriosis is considered a predominantly estrogen-dependent disease, and therefore hormonal suppression might be an attractive medical approach to treat this disease and its symptoms. Resveratrol is a natural phytoestrogen synthesized by plants and has known to have side effects such…

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Biomarker Networks Might Help Reveal the Mechanism Behind Endometriosis

Biomarker Networks Might Help Reveal the Mechanism Behind Endometriosis By Kasthuri Nair

Scientists have yet to uncover the molecular mechanisms that promote endometriosis disease progression. Xiao et al. recently published a study in Experimental and Therapeutic Medicine where they hoped to shed new light on the pathogenesis of endometriosis. In their study…

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The Deregulated Molecular Functions Involved in Malignant Transformation of Endometriosis to Endometriosis-Associated Ovarian Carcinoma

The Deregulated Molecular Functions Involved in Malignant Transformation of Endometriosis to Endometriosis-Associated Ovarian Carcinoma By Dr. Youngran Park

Endometriosis-associated ovarian cancer (EAOC) is postulated to be transformed from endometriosis. Though different deregulated functional areas were proposed accounting for the pathogenesis of EAOC transformation, there is a lack of data-driven analysis to prove this. To understand the EAOC pathogenesis…

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How good are the current guidelines on endometriosis? 

How good are the current guidelines on endometriosis?  By Dr. Youngran Park

The endometriosis was first described in 1860, yet the etiology and pathogenesis remain poorly understood. Treatment strategies vary significantly between disease severity and the symptoms of pain and/or subfertility. These challenges have resulted in multidirectional research, and the comparability of…

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Changes in Complement Proteins Affect Infertility in Women with Endometriosis

Changes in Complement Proteins Affect Infertility in Women with Endometriosis By Kasthuri Nair

Palomino et al. recently published a paper titled “The endometria of women with endometriosis exhibit dysfunctional expression of complement regulatory proteins during the mid-secretory phase” in the Journal of Reproductive Immunology where they look at the expression of CRPs during the menstrual cycle of…

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Body Mass Index and IVF outcomes in non-obese endometriosis patients

Body Mass Index and IVF outcomes in non-obese endometriosis patients By Demet Candaş Green

Endometriosis and body mass index (BMI) are inversely related, meaning obese women are at a lower risk of developing endometriosis. Similarly, women with lower BMI are considered high risk for severe types of endometriosis. The severity of endometriosis brings about…

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Can Ovarian Stimulation Increase Endometrioma Volume?

Can Ovarian Stimulation Increase Endometrioma Volume? By Kasthuri Nair

Seyhan et al. recently published a paper titled “Do endometriomas grow during ovarian stimulation for assisted reproduction? A three-dimensional volume analysis before and after ovarian stimulation” in Reproductive BioMedicine Online. The authors initially believe that ovarian stimulation, often used in…

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Can grapefruits and oranges be used for treatment of endometriosis?

Can grapefruits and oranges be used for treatment of endometriosis? By Demet Candaş Green

Naringenin is a plant-based nutrient found abundantly in grapefruits and oranges with well-known anti-cancer, anti-inflammatory, and anti-oxidant properties. Previous studies showed that naringenin could modify the estrogen receptor signaling, suggesting a role for naringenin in endometriosis. The current study performed…

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Hormonal Contraceptives and the Risk of Breast Cancer

Hormonal Contraceptives and the Risk of Breast Cancer By Kasthuri Nair

A study titled “Contemporary Hormonal Contraception and the Risk of Breast Cancer” was recently published in The New England Journal of Medicine and was immediately picked up and summarized by many well-known newspapers and broadcasting journals, including but not limited…

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EFA Medical Conference 2017: "Fertility Preservation to BRCA Mutations" Presentation by Dr. Kutluk Oktay

EFA Medical Conference 2017: By Kasthuri Nair

Dr. Kutluk Oktay is the Director of the Laboratory of Molecular Reproduction & Fertility Preservation as well as a Professor of OBGYN at Yale University School of Medicine. Dr. Oktay also presented at the EFA 2017 Medical Conference, and his…

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EFA Medical Conference 2017: "Hormone and Cytokine Sensitivity in Endometriosis" Presentation by Dr. Robert Taylor

EFA Medical Conference 2017: By Kasthuri Nair

The first presenter of the “Estrogen from Inflammation to Cancer: A Distant Link?” section of EFA 2017 Medical Conference was Dr. Robert Taylor from Wake Forest University Health Sciences. Dr. Taylor’s presentation was titled “Hormone and Cytokine Sensitivity in Endometriosis.”…

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Gestational diabetes risk in women with endometriosis

Gestational diabetes risk in women with endometriosis By Demet Candaş Green

Gestational diabetes (GD) is a common complication in pregnancy with several negative consequences for both mother and baby.  The risk of developing GD increases with maternal age and body mass index (BMI). Women with endometriosis conceive later than fertile women,…

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EFA Medical Conference 2017: "Breast Cancer in Young Women; Early Diagnosis Timely Intervention" Presentation by Dr. Stephanie Bernik

EFA Medical Conference 2017: By Kasthuri Nair

Dr. Stephanie Bernik is the Chief of Surgical Oncology of Surgery and General Surgery at the Lenox Hill Hospital. She recently presented at the EFA 2017 Medical Conference, and her presentation was titled “Breast Cancer in Young Women; Early Diagnosis…

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Treatment of minimal endometriosis in infertile women

Treatment of minimal endometriosis in infertile women By Demet Candaş Green

For women with mild/minimal endometriosis, European Society of Human Reproduction and Embryology (ESHRE) recommends the removal of endometriotic lesions to improve fertility and increase pregnancy rates. For women undergoing assisted reproductive treatment, there is ongoing debate whether surgical removal of…

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A Combination Treatment of Psychotherapy With Somatosensory Stimulation for Pain Reduction

A Combination Treatment of Psychotherapy With Somatosensory Stimulation for Pain Reduction By Kasthuri Nair

Women suffering from endometriosis often cite pelvic pain, anxiety, and depression as some of the worst core symptoms experienced due to the disease; however, emerging research has shown these signs, specifically pelvic pain, may be influenced by psychological trauma. In…

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EFA.MC.2017.“The Abnormal Embryos That Aren’t”,“Tens of thousands of women thought they couldn't have babies: But what if they could.”Dr. Norbert Gleicher Dr. Monica Halem

EFA.MC.2017.“The Abnormal Embryos That Aren’t”,“Tens of thousands of women thought they couldn't have babies: But what if they could.”Dr. Norbert Gleicher Dr. Monica Halem By Özge Özkaya

The presentation started with the story of Monica Halem who had endometriosis and had been trying to conceive using in vitro fertilization VF), but was told that none of her fertilized embryos would be viable based on pre-implantation genetic screening…

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Progesterone resistance can cause endometriosis

Progesterone resistance can cause endometriosis By Demet Candaş Green

Progesterone is a steroid hormone produced by the corpus luteum of ovaries. Abnormal progesterone signaling (i.e., progesterone resistance) in the endometrium has been implicated in the establishment of eutopic and ectopic endometrial implants. Several causes for faulty progesterone signaling have been…

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EFA Medical Conference 2017: "The Environmental Risks of Breast Cancer" Presentation by Dr. Marisa Weiss

EFA Medical Conference 2017: By Kasthuri Nair

The second speaker in the subsection of the conference titled “Estrogen from Inflammation to Cancer: A Distant Link?” was Dr. Marisa Weiss and she gave a presentation titled “The Environmental Risks of Breast Cancer: Common Ground with Endometriosis.” Dr. Weiss…

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Revisiting the wandering womb: Oxytocin in endometriosis and bipolar disorder

Revisiting the wandering womb: Oxytocin in endometriosis and bipolar disorder By Dr. Youngran Park

Despite a Hysteria (from Greek hysterikos, meaning ‘of the womb’) was dismissed as causing mental illness, recent evidence links oxytocin with diverse and correlated psychological and physical symptoms and conditions that more frequently affect women than men. This article proposes…

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Biomarkers as a Diagnostic Tool

Biomarkers as a Diagnostic Tool By Kasthuri Nair

Ahn, Singh and Tayade discuss the difficulties and delay in diagnosing Endometriosis in their paper titled “Biomarkers in endometriosis: challenges and opportunities.” Thus far research has identified a multitude of potential biomarkers that are found in various parts of the…

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Role of immune cells in endometriosis

Role of immune cells in endometriosis By Demet Candaş Green

Immune cells have essential functions in the body such as detection and clearance of abnormal cells and debris. One of the possible mechanisms for the development of endometriosis is proposed to be the impaired function of immune system cells in…

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Estrogen Receptor-β in Women’s Health

Estrogen Receptor-β in Women’s Health By Yu Yu

Since the discovery of estrogen receptor (ER), there has been a vast number of studies regarding its functions in cellular and physiological processes. The identification of estrogen receptor-β (ERβ), a second receptor, resulted in a much more complex understanding of the…

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An update of estrogen receptors on human disease

An update of estrogen receptors on human disease By Yu Yu

Estrogens and its receptors influence numerous human physiological processes. Two estrogen receptors exist, including estrogen receptor α (ERα) and ERβ. Hence, it is essential to elucidate the functions of these receptors in healthy and diseased states. This is particularly important…

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Endometriosis May Be Causing Women to Become More Sensitive to Pain

Endometriosis May Be Causing Women to Become More Sensitive to Pain By Özge Özkaya

Inflammation caused by endometriosis may be changing the way a woman perceives pain, found a new study published in the journal Regional Anesthesia and Pain Medicine.   According to Dr. Neziri Alban at University Hospital of Bern, Switzerland and the co-authors…

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The Role of Natural Killer Cells in the Development of Endometriosis Unravelled

The Role of Natural Killer Cells in the Development of Endometriosis Unravelled By Özge Özkaya

Specialized immune cells called natural killer cells found in the peritoneal fluid of women with severe endometriosis may facilitate the development of the disease, according to a study published in the American Journal of Reproductive Immunology.   This finding could help…

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Roles of Progesterone in Endometrial Cancer, Endometriosis, Uterine Fibroids, and Breast Cancer

Roles of Progesterone in Endometrial Cancer, Endometriosis, Uterine Fibroids, and Breast Cancer By Yu Yu

Progesterone is an important hormone, which together with estrogen prepares the women endometrium and breast tissue for pregnancy. The roles of progesterone in human tissues and diseases can be difficult to decipher. While there is a strong evidence for the…

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Endometriosis Does Not Increase Overall Risk of Breast Cancer, Study Finds

Endometriosis Does Not Increase Overall Risk of Breast Cancer, Study Finds By Özge Özkaya

Endometriosis is not associated with the overall risk of breast cancer, according to a study published in the journal Obstetrics & Gynecology.  The condition may, however, be significantly associated with an increased risk of breast tumors that express estrogen receptors (ER)…

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Is there a risk of developing breast cancer for women with endometriosis?

Is there a risk of developing breast cancer for women with endometriosis? By Murat Osman

Understanding the interplay between the development of breast cancer and the presence of endometriosis and vice versa is complex since many risk factors including hormone or genetic variations and medical treatments have a role in each disease process. Thus, parsing…

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Association between blood inflammatory markers and the risk of endometriosis

Association between blood inflammatory markers and the risk of endometriosis By Yu Yu

Previous studies have suggested that aberrant immunologic and inflammatory responses may play a role in the pathogenesis of endometriosis. Peritoneal fluid collected from endometriosis contains elevated immune cells that may enhance the survival of endometriosis by secreting growth factors and…

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A Two-Wave Molecular Mechanism for Endometriosis Disease Progression

A Two-Wave Molecular Mechanism for Endometriosis Disease Progression By Kasthuri Nair

Kobayashi et al. recently published a review paper in Molecular Medicine Reports titled “Pathogenesis of endometriosis: The role of initial infection and subsequent sterile inflammation,” which discusses at length the role of non-specific bacterial infection and sterile inflammation in the…

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Is operation the best option for infertile patients with digestive endometriosis?

Is operation the best option for infertile patients with digestive endometriosis? By Demet Candaş Green

A severe form of endometriosis affecting 8-12% of women with deep endometriosis is bowel endometriosis. Bowel involvement with associated infertility is a serious challenge for gynecologists who must choose between two main therapeutic options: surgery or medically assisted procreation (e.g.…

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The Endometriosis Fertility index Could Help Better Predict the Chance of Conceiving After Laparoscopy

The Endometriosis Fertility index Could Help Better Predict the Chance of Conceiving After Laparoscopy By Özge Özkaya

The endometriosis fertility index (EFI) can more reliably predict the chance of a woman getting pregnant following endometriosis surgery compared to the revised-American Society of Reproductive Medicine score, according to a study published in the scientific journal Gynecologic and Obstetric…

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A New Treatment Time-Table for Controlling Endometriosis-Associated Pelvic Pain

A New Treatment Time-Table for Controlling Endometriosis-Associated Pelvic Pain By Kasthuri Nair

It is no secret that Endometriosis is an extremely painful disease. Unfortunately, science has yet to determine a treatment that can effectively treat the disease or the associated pain. In their paper titled “Ethinylestradiol 20 mg/drospirenone 3 mg in a…

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Mitogen-Activated Protein Kinase p38 modulates Inflammation in Endometriosis

Mitogen-Activated Protein Kinase p38 modulates Inflammation in Endometriosis By Yu Yu

The p38 mitogen-activated protein kinase (MAPK) is a serine/threonine kinase, which transduces signals within the cell in response to various environmental stimuli. In doing so, it mediates intracellular signaling of cytokine production, cell proliferation, and apoptosis amongst many other cellular…

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CCL19/CCR7 Interaction can Casue Characteristic Cell Proliferation

CCL19/CCR7 Interaction can Casue Characteristic Cell Proliferation By Kasthuri Nair

In their paper published in the American Journal of Reproductive Immunology titled “CCL19/CCR7 contributes to the pathogenesis of endometriosis via PI3K/Akt pathway by regulating the proliferation and invasion of ESCs,” Diao et al. hope to elucidate one of the mechanisms…

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Fetal Membranes Abnormalities in Pregnant Women with DIE

Fetal Membranes Abnormalities in Pregnant Women with DIE By Kasthuri Nair

Marcellin, Méhats, and Gogusev formulated a study where they analyzed alterations in the fetal membranes (FM) of women suffering from severe endometriosis. Their paper titled “Histopathological Alterations in Fetal Membranes of Women With Endometriosis” was recently published in the Reproductive…

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Serum AMH Levels Play an Important Role In Fertility Preservation

Serum AMH Levels Play an Important Role In Fertility Preservation By Kasthuri Nair

One of the options available for women who suffer from endometriosis related infertility is cryopreservation. This option is only viable if the woman in question does not suffer from the low ovarian reserve. Garavaglia et al. suggest using pre-surgical serum…

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Endometriosis increases the risk of miscarriage

Endometriosis increases the risk of miscarriage By Demet Candaş Green

This systematic review was based on four studies in literature and included a total of 31,167 pregnant women with endometriosis. Several studies were previously performed to establish the association between endometriosis and pregnancy loss with contradictory results. This somewhat large…

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Updates in the Field of Endometriosis: Epigenetics

Updates in the Field of Endometriosis: Epigenetics By Kasthuri Nair

In this chapter titled “A Review of the Epigenetic Contributions to Endometriosis,” Grimstad and Decherney examine various epigenetic influences that drive endometriosis disease progression. The epigenetic alterations they discuss include DNA methylation, histone modification, chromatin architecture changes, nuclear receptor modulation,…

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Updates in the Field of Endometriosis: Fertility Preservation

Updates in the Field of Endometriosis: Fertility Preservation By Kasthuri Nair

“Endometriosis and Fertility” is a chapter dedicated to examining the role of endometriosis and endometriomas in decreasing fertility. In other words, the authors of this chapter discuss the relationship between endometriomas, surgeries, and infertility. Barnett, Banks and Decherney also deliberate…

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Updates in the Field of Endometriosis

Updates in the Field of Endometriosis By Kasthuri Nair

A lot of progress has been made thus far in the field of endometriosis. Research has discovered various genetic and epigenetic components involved in endometriosis. There has also been a progression in the diagnosis and treatment of the disease since…

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Endometriosis Fertility Index Anticipates Pregnancy in Women with Endometriosis

Endometriosis Fertility Index Anticipates Pregnancy in Women with Endometriosis By Kasthuri Nair

Women are often afflicted by endometriosis during their reproductive years and can be faced with the prospect of infertility. These women also undergo treatments and procedures that can further affect their fertility. Consequently, in 2010, Adamson and Pasta came up…

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Arcyriaflavin A Decreases Endometriosis Cell Viability and Proliferation

Arcyriaflavin A Decreases Endometriosis Cell Viability and Proliferation By Vishaan Nursey

The purpose of this research topic was to determine whether Arcyriaflavin A could serve as a potential new therapeutic option for those suffering from Endometriosis. Arcyriaflavin A is a Cyclin D1 inhibitor. Cyclin D1 regulates the cell cycle by interacting…

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A Systematic Review of Guidelines for Diagnosis and Management of Endometriosis

A Systematic Review of Guidelines for Diagnosis and Management of Endometriosis By Yu Yu

Guidelines are systematically developed statements derived from best research evidence to improve patient care through informed clinical practice. Appropriate guidelines can reduce unwarranted variations health practice and the implementation of better interventions. Endometriosis commonly has three different manifestations, including peritoneal…

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First-line surgery followed by ART versus ART alone among women with colon-involving endometriosis.

First-line surgery followed by ART versus ART alone among women with colon-involving endometriosis. By Murat Osman

Endometriosis, a disease characterized by the presence of endometrial tissue outside the uterus, may cause pelvic and gynecologic complications that affect fertility in women of reproductive age. Several forms of endometriosis have been observed that are characterized by the varying…

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Dienogest for Endometriosis

Dienogest for Endometriosis By Kasthuri Nair

Laganà et al. recently published an article in Expert Opinion on Drug Metabolism & Toxicology titled “Clinical dynamics of Dienogest for the treatment of endometriosis: from bench to bedside.” This article explored the benefits of using Dienogest, a progestin, to…

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The Potential Molecular Mechanisms that Drive Endometriosis Progression

The Potential Molecular Mechanisms that Drive Endometriosis Progression By Kasthuri Nair

Endometriosis is a mysterious disease in that the exact mechanism that causes the illness is still at large. Yang et al. recently published a paper in the European Review for Medical and Pharmacological Sciences that hopes to elucidate the molecular…

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An Antagonist for Endometriosis Disease Progression: LINC00261

An Antagonist for Endometriosis Disease Progression: LINC00261 By Kasthuri Nair

The molecular mechanisms surrounding endometriosis remain elusive to this day. Sha et al. from Wenzhou Medical University, China, reported that LINC00261, a long non-coding RNA, may play a substantial role in inhibiting the pathogenesis of this painful illness. Their paper…

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The Role of IL-35 in the Pathogenesis of Endometriosis

The Role of IL-35 in the Pathogenesis of Endometriosis By Kasthuri Nair

The molecular mechanism that drives endometriosis remains elusive to this day. Zhang et al believe that interleukin 35 (IL-35) plays a role in the pathogenesis of the disease. Their recent publication in Reproductive Sciences titled “Upregulation of Interleukin 35 in…

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Indirect assessment of endometriosis prevalence in general population

Indirect assessment of endometriosis prevalence in general population By Özge Özkaya

The prevalence of endometriosis is 10 percent among the general population, estimates a study published in the Journal of Gynecology Obstetrics and Human Reproduction. It is very difficult to estimate the prevalence of endometriosis in the general population. Seventeen different…

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Bowel Involvement in Deep Infiltrating Endometriosis

Bowel Involvement in Deep Infiltrating Endometriosis By Özge Özkaya

Cleansing the colon before an ultrasound makes it easier to detect rectal nodules of deep infiltrating endometriosis, found a study published in the Journal of Minimally Invasive Gynecology.  Cleansing the colon before a surgery is called bowel preparation and is…

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Ping-Chong-Jiang-Ni Formula: A Natural Treatment

Ping-Chong-Jiang-Ni Formula: A Natural Treatment By Kasthuri Nair

In the world of modern medicine, natural and herbal remedies are often under utilized. Liang et al. recently published an article in Evidence-Based Complementary and Alternative Medicine where they explored the benefits of using a Chinese Herbal Medicine to treat…

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Dienogest for endometriosis pain in clinical practice

Dienogest for endometriosis pain in clinical practice By Yu Yu

Dienogest is a synthetic progestogen that has been marketed as a medical treatment for endometriosis. Previous randomized controlled clinical trials have shown that it is effective in women with endometriosis at different stages of the disease. Given its recent introduction,…

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Endometriosis and Productivity at Home and in the Workplace

Endometriosis and Productivity at Home and in the Workplace By Kasthuri Nair

Soliman et al. recently published an original paper in the Journal of Managed Care and Specialty Pharmacy that discusses the impact that endometriosis symptoms have on an individual’s productivity level at home and work. This publication is titled “The Effect…

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Inhibition of key neurotransmitter could reduce endometriosis-related pain

Inhibition of key neurotransmitter could reduce endometriosis-related pain By Asli Bahadirli Talbott

This study published in the scientific journalMolecular MedicineReports[link] by Lian et al. from Shanghai, China, aims to explore the relationship between transient receptor potential vanilloid type 1 (TRPV1) and endometriosis-associated pain. Pain is the most common symptom for women with…

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The Benefits of Primary Surgery

The Benefits of Primary Surgery By Kasthuri Nair

Ahmad, Hussin, and Ahmad recently conducted a cohort study, and they published the results within an article titled “An evaluation of the quality of life in women with endometriosis who underwent primary surgery: a 6-month follow-up in Sabah Women &…

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ICSI Outcomes for Laparoscopic Intervention of Endometriosis

 ICSI Outcomes for Laparoscopic Intervention of Endometriosis By Kasthuri Nair

Women with endometriosis can have trouble conceiving and often turn to fertility treatments for help. Guler et al. recently published a paper in Systems Biology in Reproductive Medicine titled “The Impact of laparoscopic surgery of peritoneal endometriosis and endometrioma on…

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How ERα is regulated in endometriosis?

How ERα is regulated in endometriosis? By Yu Yu

Endometriosis pathogenesis is largely influenced by estrogen. Ectopic endometrium has altered expression of ERα compared to the eutopic endometrium. It is unclear what biological processes regulate such alteration. The article by Toderow et al. in Archives of Gynecology and Obstetrics…

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Pregnancy Risks Associated with Severe Endometriosis

Pregnancy Risks Associated with Severe Endometriosis By Kasthuri Nair

Living with endometriosis can be painful and challenging; however, the challenges increase for women that are pregnant and have this disease. Recently, BJOG published an article titled “The ominous association between severe endometriosis, in-vitro fertilization, and placenta praevia: Raising awareness,…

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Deep Infiltrating Endometriosis, Surgery and Fertility

 Deep Infiltrating Endometriosis, Surgery and Fertility By Kasthuri Nair

Carneiro, Costa, and Ávila recently published an article in a scientific journal named Reproduction, titled “To operate or not to operate on women with deep infiltrating endometriosis (DIE) before in vitro fertilization (IVF),” that explored the relationship between DIE and infertility.…

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The Endometrium Itself is Genetically Different in Endometriosis Patients

The Endometrium Itself is Genetically Different in Endometriosis Patients By Özge Özkaya

Researchers in China identified a number of genes that are differentially expressed in the eutopic endometrium of women with endometriosis and those without. The researchers think that these genes may be involved in the development of endometriosis and that they…

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Body size, adult height and endometriosis

Body size, adult height and endometriosis By Asli Bahadirli Talbott

Endometriosis is associated with lean body size during childhood, adolescence, and adulthood; tall total adult height; and tall sitting height, found a study published in the scientific journal, Human Reproduction. This study aimed to investigate the relationships between body size across…

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Women with endometriosis suffer from anxiety and depression

Women with endometriosis suffer from anxiety and depression By Demet Candaş Green

Endometriosis is considered a disabling condition that may significantly affect social relationships, sexuality and mental health of patients. Women who suffer from endometriosis report high levels of anxiety and depression and other psychological disorders. In this review article, the authors…

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Could the cell surface protein "EWI-2" be the new diagnostic marker for endometriosis?

Could the cell surface protein By Murat Osman

Further Understanding: Researchers from the Reproductive Medicine Center of Wuhan University sought to observe the differential expression of EWI-2, (a cell surface protein and an early activation marker, also known as IGSF8 - Immunoglobulin superfamily member 8) in 145 women…

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Endometriosis as a Barrier to Fertility

Endometriosis as a Barrier to Fertility By Murat Osman

Some of the articles in the from the journal "Acta Obstetricia et Gynecologica Scandinavica (AOGS) issue are discussed in further detail below: Pain caused by endometriosis has been seen to significantly impact women's physical, psychosocial, and sexual health. Although endometriosis has been…

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Can a cure be developed for endometriosis?

Can a cure be developed for endometriosis? By Asli Bahadirli Talbott

The Lancet correspondence highlights that regardless of the importance of endometriosis; its full socioeconomic impact is underestimated and endometriosis research is considerably underfunded. The Endometriosis Priority Setting Partnership (PSP) which includes women with endometriosis, their supporters, health-care practitioners, endometriosis researchers, and representatives from…

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Endometriosis Reduces Chance of Having a Baby Even with Assisted Reproduction, Study Shows

Endometriosis Reduces Chance of Having a Baby Even with Assisted Reproduction, Study Shows By Özge Özkaya

Endometriosis significantly decreases the likelihood of conceiving even with assisted reproductive technique such as in vitro fertilization (IVF) and Intracytoplasmic sperm injection (ICSI), according to a study published in the European Journal of Obstetrics & Gynecology and Reproductive Biology. In…

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Scientists Grow Miniature Model of Human Endometrium in the Laboratory

Scientists Grow Miniature Model of Human Endometrium in the Laboratory By Özge Özkaya

Researchers in the U.K. managed to grow a miniature functional model of the human endometrium in the laboratory for the first time. These so-called organoids could help scientists better understands events associated with conditions such as endometriosis and help them…

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Women with Endometriosis May Require Additional Care During Pregnancy and Labour

Women with Endometriosis May Require Additional Care During Pregnancy and Labour By Özge Özkaya

Women with endometriosis have a higher risk of bleeding after giving birth, found a study published in the Chinese Medical Journal. In addition, women with endometriosis who conceived by assisted reproduction may also have a higher risk of bleeding after…

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Metabolomic profiling and biochemical evaluation of the follicular fluid of endometriosis patients.

Metabolomic profiling and biochemical evaluation of the follicular fluid of endometriosis patients. By Yu Yu

Metabolites are the intermediates and products of metabolism from our body. Increasingly the study of metabolite content in biological systems can be used to derive useful information to identify disease-related markers, such as the use of glucose in the blood…

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Women with Endometriosis Should be Closely Monitored During Pregnancy and Birth, Study Suggests

Women with Endometriosis Should be Closely Monitored During Pregnancy and Birth, Study Suggests By Özge Özkaya

Women with endometriosis have a significantly higher risk of developing several complications during pregnancy and delivery such as preeclampsia and placental complications, according to a study by Danish researchers. In addition, babies born to mothers with endometriosis have a higher…

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