By Selma OransayVisual representation of endometriosis pain
By Selma Oransay
Endometriosis is accompanied by severe chronic pelvic pain that impacts quality of life, relationships, and work conditions. Studies aiming to improve pain are frequently encountered in the literature. Nonetheless, pain research is complex due to its subjective nature, and cannot…
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Current practice in robotic surgery for deep-infiltrating endometriosis
By Selma Oransay
Today, surgical excision of endometriotic lesions is the only cytoreductive procedure for managing endometriosis. Hormonal treatment may partly relieve the symptoms, but it suppresses rather than cytoreduction of the disease. Minimally invasive surgery is usually the most preferred method due…
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By Eylül GÜNQuercetin and its effects on endometriosis
By Eylül GÜN
Endometriosis, as a disease characterized by chronic inflammation and fibrosis, could be a potential target for quercetin, a flavonoid found in various foods and botanicals, and a known senolytic agent with many effects including antioxidant, anti-inflammatory, and immune-modulatory properties. Studies…
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Management of uterine adenomyomas with percutaneous cryoablation.
By Selma Oransay
Adenomyosis can negatively affect the quality of life by causing abnormal bleeding, pelvic pain, dysmenorrhea, and dyspareunia. It is often associated with endometriomas and/or leiomyomas. Treatment of the disease differs as conservative or radical, as well as pharmacological or surgical. For…
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Endometriosis treatment at diagnosis: Is it possible?
By Eylül GÜN
For most cases of endometriosis, a diagnostic laparoscopy followed by a therapeutic laparoscopy is recommended by The National Institute for Health and Care Excellence. Hypothesizing that patients with endometriosis might benefit from receiving only a therapeutic laparoscopy, combining diagnosis and…
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By Nasuhi Engin AydinNew visions on diaphragmatic endometriosis
By Nasuhi Engin Aydin
Elvin Piriyev and Thomas Römer from Academic Hospital Cologne Weyertal, Germany have published their retrospective analysis of diaphragm endometriosis in a recent issue of the European Journal of Obstetrics and Gynecology. About 7-10% of reproductive-age women have endometriosis but diaphragm…
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Bladder Function Alterations Following Endometriosis Surgery
By Selma Oransay
Although endometriosis is a common gynecologic disorder, urinary tract involvement is present in only 1-5% of these patients. When endometriosis invades the urinary tract, clinical symptoms may vary from asymptomatic to frequency, urgency, bladder pain, hematuria, and recurrent urinary infections.…
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By Hale Goksever CelikComplementary and alternative therapies for managing acyclic pelvic pain in women with endometriosis
By Hale Goksever Celik
The quality of life in women with endometriosis is affected depending on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Because of different clinical spectrum and diagnostic delays, there is no optimum management…
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Beware of deep endometriosis involving ureter
By Nasuhi Engin Aydin
Dr. Vacaroiu and colleagues from the Romanian academic milieu have published a case report of urinary tract endometriosis that could have otherwise resulted in kidney failure when remained undiagnosed. This case appeared in a recent issue of the Journal of Clinical…
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Ovarian adhesion prevention with polytetrafluoroethylene during endometrioma surgery.
By Selma Oransay
The World Health Organization defined infertility as the inability to conceive after 12 months of regular unprotected intercourse or after six months of fertility-focused intercourse. Depending on the chronic inflammatory character and causing adhesion formations within the peritoneum, endometriosis is…
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Peritoneal fluid in young women with endometriosis
By Selma Oransay
Many blood substances are present in peritoneal fluid due to their derivation from the transudation of blood through the peritoneal surface. Ectopic endometriotic lesions can also change the medium to contribute to the definition of the local environment of the…
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Analysis of steroid hormone receptors in endometriotic tissues reveals chaotic results
By Nasuhi Engin Aydin
A group of researchers from academic institutions located at Australia and New Zeland, led by Dr. Holdsworth-Carson, have published their recent findings on steroid receptors in peritoneal endometriosis lesions by immunohistochemistry, in the journal Reproduvtive Biomedicine Online. Endometriosis is…
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The effect of medical treatment on sexual function and quality of life in women with endometriosis
By Hale Goksever Celik
Women with endometriosis suffer from dysmenorrhea, dyspareunia and chronic pelvic pain, all of which has significant negative consequences on their physical and psychological health regarding sexual function, work and social relationships. Biasioli et al. from Italy, published an article entitled…
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By Özge ÖzkayaRobotic Surgery For Endometriosis
By Özge Özkaya
Robotic surgery is an option for the treatment of severe endometriosis, according to the results of a preliminary comparative study published in the Journal of Minimally Invasive Gynecology. However, the approach is associated with higher costs. “Next studies should identify…
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Embryo Morphokinetics of Endometriotic Patients by Time Lapse Monitoring
By Selma Oransay
Many studies showed adverse effects of endometriosis on oocyte quality due to increased apoptosis and dysregulation of molecular pathways related to the development and growth of granulosa cells resulting on developmental arrest in embryos of women with endometriosis. Time-lapse monitoring…
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A non-invasive test to determine the risk of endometriosis in women having chronic pelvic pain or unexplained infertility
By Hale Goksever Celik
Women having endometriosis may suffer from chronic pelvic pain and/or infertility, both of which diminish the quality of life in these women. Minimalization of the time between the onset of symptoms and diagnosis is essential to improve patients’ lives. However,…
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Deep infiltrating endometriosis and postoperative pregnancy outcomes
By Selma Oransay
Although the current ESHRE guidelines state that there is no strong evidence to support surgical intervention to improve the spontaneous pregnancy rate in women with deep infiltrating endometriosis and advise Assisted reproduction technology irrespective of the severity of endometriosis, several studies…
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Reviewing all you want to know on endometriosis !
By Nasuhi Engin Aydin
Academicians from the International University of Sarajevo, Bosnia, and Lincoln Medical School, UK have written a comprehensive updated review on endometriosis covering many aspects of endometriosis and published their paper as an open-access manuscript in the journal “Pathology-Research and Practice”. …
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The overlap of endometriosis and polycystic ovarian syndrome
By Eylül GÜN
Polycystic ovarian syndrome (PCOS) is one of the most common causes of female subfertility similar to endometriosis. It has been hypothesized that owing to the underlying pathophysiological mechanisms, women with endometriosis are at a greater risk of having PCOS than…
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Live Birth Rate for ovarian stimulation protocols after laparoscopic endometrioma cystectomy.
By Selma Oransay
The laparoscopic cystectomy of the ovaries is the first-line infertility treatment in patients with endometriomas. However, a possible diminished ovarian capacity after cystectomy with ovarian failure to respond to the gonadotropin stimuli seems an undesirable result of this procedure. Controlled…
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Endometrioma surgery and the ovarian reserve
By Selma Oransay
Traditionally, cystectomy is the gold standard for surgical approach owing to the reduced risk of recurrence. Still, it may lead to a reduction in postoperative ovarian volume and can be a cause of ovarian failure. The recent conservative surgical management of…
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Treatment of superficial dyspareunia using topical estrogens in postmenopausal women with a history of endometriosis
By Hale Goksever Celik
Genitourinary syndrome of menopause is defined as a collection of symptoms and signs caused by hypoestrogenic changes to the labia majora/minora, clitoris, vestibule/introitus, vagina, urethra, and bladder that occur in menopausal patients. Sexual dysfunction and superficial dyspareunia can be experienced…
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Is continuous hormonal treatment safe and healthy method for endometriotic patients?
By Selma Oransay
One of the studies related to the search for new markers in pathophysiologic causes of endometriosis is circulating microparticles and their subset "tissue factor". In response to damage, activation, or apoptosis, these microparticles are found in human plasma, urine, saliva,…
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Novel surgical solutions for catamenial pneumothorax
By Eylül GÜN
Catamenial pneumothorax is a spontaneous pneumothorax that occurs during or right after menstruation and is thought to be caused by thoracic endometriosis that includes the diaphragm, lung, and parietal pleura. The solution is surgical removal of endometrial lesions, however, a…
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The compliance for post-surgical follow-ups after endometriosis surgery
By Selma Oransay
. The patient's adherence to follow-ups after surgery is essential as it is the only way to evaluate the surgery's benefits in improving pain symptoms and recurrences, measuring the quality of life, and fertility outcomes. . Dr. Szabo and his…
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"Transumblical single-port laparoscopy" for deep infiltrating endometriosis.
By Selma Oransay
Deep infiltrating endometriosis patients have multi-system involvements, severe pelvic adhesions, and pelvic pain. Dyspareunia, dysmenorrhea, infertility, gastrointestinal symptoms, and lower urinary tract symptoms seriously affect their quality of life. Although hormonal therapy may be the first choice for treating endometriosis,…
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Postoperative outcomes of laparoscopic rectosigmoid resection for bowel endometriosis.
By Selma Oransay
Rectosigmoid endometriosis comprises 80-85% of all bowel endometriosis cases and can be localized in the rectovaginal septum, uterosacral ligaments, retro-cervical region, and parametrium. Symptoms of rectosigmoid endometriosis include abdominal bloating, constipation-diarrhea, lower-back pain, dyschezia, and sometimes cyclic rectal bleeding. Minimally…
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Outcomes of improving chronic pelvic pain with "immersive digital therapeutics" at home.
By Selma Oransay
Studies have shown that virtual reality can effectively treat acute pain experienced by burn victims, during labor, dental surgery, or for chronic musculoskeletal, neuropathic, and cancer pain. Considering the effectiveness of treating chronic pelvic pain at home, Merlot et al.…
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Menopause-management strategies for women with endometriosis.
By Selma Oransay
Menopausal hormonal therapy is the most effective treatment for menopausal symptoms, such as hot flushes, sweating, sleep disturbances, mood changes, and joint pain. Approximately 75% of all women experienced some degree of these symptoms, while 2-4% were diagnosed with endometriosis. Menopausal…
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Endometriosis and Progesterone Resistance
By Selma Oransay
Progesterone resistance is the unresponsiveness of endometrium with subsequent dysregulation of the progesterone signaling pathway, and endometrial gene works. Progestins, on the other hand, are the first-line treatment choice, especially for long-term treatment of endometriosis. In the clinics, one-third of…
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When to start ART after laparoscopic treatment of endometriosis?
By Selma Oransay
Laparoscopy combined with histopathologic confirmation of endometriosis is the reference standard for diagnosing endometriosis. Additionally, laparoscopic surgery is considered the most effective way to approach infertility induced by endometriosis. The surgical factors influencing the outcome of treating the infertility of…
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Improving the quality of life: The role of cognitive behavioral therapy after endometriosis surgery
By Eylül GÜN
Endometriosis and its symptoms have been associated with poor mental health and reduced quality of life. Cognitive behavioral therapy is recognized as an effective psychological treatment for managing depression, anxiety, and stress. Although surgery for endometriosis improves a patient's quality…
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Another New Approach Could Help Diagnose deep Infiltrating endometriosis
By Özge Özkaya
Elastography could help distinguish deep infiltrating endometriosis (DIE) nodules from non-endometriotic tissue at different locations, according to a new study published in Ultraschall in der Medizin - European Journal of Ultrasound. The potential of the technique in improving the diagnosis…
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Ultrasonographic findings predicting parametrial deep endometriosis
By Selma Oransay
Transvaginal ultrasonographic evaluation is the primary imaging technique to rule out deep endometriosis. Although the International Deep Endometriosis Analysis Group (IDEA) published a consensus to standardize the nomenclature of ultrasonographic pelvic examination in women with suspected deep endometriosis, parametrial deep endometriosis…
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Integrative medical management of endometriosis
By Selma Oransay
This lecture entitled "Integrative Medical Management of Endometriosis" was presented by Dr. Pinar Kodaman, Director of the endoscopic reproductive surgery program and Assoc. Professor of Clinical ObGyn and Reproductive Sciences at the Yale School of Medicine. In addition to surgery which…
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Which surgery for deep endometriosis? Laparoscopic shaving or rectal resection?
By Selma Oransay
This keynote lecture entitled "Deep endometriosis: The place of laparoscopic shaving" was presented by Dr. Jacques Donnez, the director of the infertility research unit at the Catholic University of Louvain, Brussels, Belgium, at the Annual International Medical Conference of the Endometriosis Foundation…
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The role of neurogenic inflammation in endometriosis
By Eylül GÜN
Prof. Mechsner from Charité—Universitätsmedizin Berlin, Germany presented on neuroimmunomodulation and its clinical impact on endometriosis at the Annual International Medical Conference of the Endometriosis Foundation of America. Endometriosis is a complex disease and the main symptoms are all pain-related. The pain mechanisms are…
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Stem cells could be a good choice for therapeutic steps in many gynecologic disorders, including endometriosis
By Nasuhi Engin Aydin
Dr. Liu from the First Hospital of Jilin University, China, and colleagues from China and the USA have published their comprehensive review on the therapeutic gateways of stem cells in female genital tract disorders in a recent issue of Life…
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Transvaginal Hydro laparoscopy for diagnosing and treatment of early stages of endometriosis
By Selma Oransay
Transvaginal hydro laparoscopy is a minimally invasive procedure that allows the exploration of the female pelvis. An obliterated Douglas pouch by a fixed retroverted uterus, an ovarian endometrioma greater than 2 cm, and the presence of deeply infiltrated endometriosis are…
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Does Endometriosis Surgery Increase the Rate of Pregnancy?
By Özge Özkaya
Surgery to treat colorectal endometriosis leads to a high rate of pregnancy following the operation, found a new study published in the Journal of Minimally Invasive Gynecology. The authors of the study said, “studies with a high level of evidence…
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Histopathologic examination always has the final word in tubal endometriosis
By Nasuhi Engin Aydin
Hai-Ning Jiao and coworkers from the Department of Obstetrics and Gynecology of Shanghai Jiao Tong University School of Medicine, China, reported the salient features of 30 tubal endometriosis cases in the World Journal of Clinical Cases. Tubal endometriosis is characterized…
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New adapted ESHRE guidelines for endometriosis.
By Selma Oransay
Eun Hee Yu and Jong Kil Joo from the Department of Obstetrics and Gynecology of Pusan National University School of Medicine, Republic of Korea, published a commentary on the 2022 ESHRE guidelines, referring to the representative changes and important updates in a recently…
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Laparoscopic resection of bladder endometriosis
By Selma Oransay
When we talk about deep-infiltrating endometriosis, one of the most commonly affected organs in the urinary tract is the bladder, with a prevalence of 80%. Bladder endometriosis can be defined as the existence of the endometrial glands and stroma inside…
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By Bahar YukselThis time it is good to have this stress: Endoplasmic reticulum stress and endometriosis.
By Bahar Yuksel
Endometriosis is a hormone-based inflammatory disease. Cell-level therapeutic options are very popular when resistance to cell death capacity of endometriotic cells is on the table. In the review conducted by Hussein Riyadh Abdul Kareem Al‑Hetty et al, the authors summarized…
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Comparison of two surgical approaches for endometriosis.
By Selma Oransay
Endometriosis is one of the causes of infertility in women. But the pathophysiology of infertility caused by endometriosis is not yet clear. Hormonal disorders, abnormal peritoneal function, distorted pelvic anatomy, and multiple cesarean deliveries are among the accused. Dr. Li…
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How Common is Adenomyosis Among Subfertile Women?
By Özge Özkaya
Around 10% of women who have reduced fertility have isolated adenomyosis, according to a new study published in the scientific journal Ultrasound in Obstetrics & Gynecology. The prevalence of the disease seems to vary according to the presence of endometriosis…
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Gathering brings relief to endometriosis pain.
By Bahar Yuksel
Endometriosis is an inflammatory disease that should be managed on a multidisciplinary basis. In a study conducted in Porto Rico, the authors designed a multitask organization to support women with endometriosis and analyzed its feasibility and accessibility. In order to define…
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Relation between hormone replacement therapy and postmenopausal endometriosis.
By Bahar Yuksel
The faith of endometriosis after oophorectomy with hysterectomy is unknown. It is clear that applying only a hysterectomy but leaving the affected tissue behind is not a solution for endometriosis-related symptoms. Either total clearance or leaving endometriotic tissues behind when…
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Diaphragmatic Endometriosis: a Call for Awareness
By Nasuhi Engin Aydin
Dr. Pagano and colleagues from the Department of Gynecology and Obstetrics, University of Bern, Switzerland, have published a prospective cohort study on diaphragmatic involvement in endometriosis patients in a recent issue of “The Journal of Minimally Invasive Gynecology”. Endometriosis is…
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Ultrasonographic Presurgical Staging and Classification of Endometriosis
By Selma Oransay
Laparoscopic surgery is the gold standard for diagnosing endometriosis, but a preoperative imaging procedure is strongly recommended. Transvaginal sonography by a skilled examiner is not inferior to MRI diagnostics regarding sensitivity and specificity in predicting the extension of deep endometriosis. …
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Transvaginal ultrasound or MRI for retroflexed uterus in endometriosis
By Nasuhi Engin Aydin
Dr Matsuda and colleagues from the Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan have published their study evaluating the effectiveness of transvaginal ultrasound on the diagnosis of uterine retroflexion in a recent issue of “Journal of Nippon…
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Diagnostic criteria for uterosacral ligament involvement in endometriosis.
By Selma Oransay
Transvaginal ultrasonography is often used to diagnose endometriosis in suspected women due to its high resolution, low cost, and relatively low discomfort. Histologic confirmation of laparoscopically removed specimens is still the gold standard for appropriate diagnosis. The team led by…
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Endometriosis and the body perception
By Hale Goksever Celik
The most common endometriosis-associated symptoms are pelvic pain, dysmenorrhea, dyspareunia, and infertility. Women with endometriosis should be managed due to the significant impact of these symptoms on their quality of life. Body perceptions of these women are also affected depending…
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How accurate is ultrasonography in evaluating deep infiltrating endometriosis?
By Eylül GÜN
Deep infiltrating endometriosis (DIE) appears to be the most severe form of endometriosis comprising 15-30% of all endometriosis patients. The difference in the presentation of the lesions ranges from simple adhesions to infiltrative nodules. Even though there is no consensus…
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Efficacy of Uterine Artery Blockage in Endometriosis Management
By Nasuhi Engin Aydin
Dr. Li Ma and associates from Liaoning, China have published their results of a computerized database search on the role of uterine artery embolization in endometriosis in a recent issue of the periodical “Computational Intelligence and Neuroscience”. Currently, the management…
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Foreseeing what will be seen on laparoscopy
By Bahar Yuksel
Endometriosis diagnosis still relies on preoperative prediction and its confirmation by taking biopsies. Thus, a prediction model for forecasting what would be waiting for the surgeon and the patient will be promising to get prepared. In the study conducted…
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Deep lateral parametrial endometriosis nerve-sparing surgery
By Selma Oransay
Dr. Kanno et al. from the Department of Obstetrics and Gynecology of Kurashiki medical center, Okayama, Japan recently published a deep lateral parametrial endometriosis case report in the journal named Fertility and Sterility. The aim is to demonstrate the technical and…
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Time to change out taboos about the radiologic evaluation of scar endometriosis
By Bahar Yuksel
Scar endometriosis is one of the rare forms of endometriosis. According to traditional belief, it has always been evaluated radiologically on menstruation days. In the study conducted by Balaban et al, the authors compared the differences in lesions according to…
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The management of diaphragmatic endometriosis
By Selma Oransay
Thoracic endometriosis is a rare disease, and it is likely to have been underdiagnosed and underreported. Optimal diagnostic testing and management options are yet to be determined. Imaging for thoracic endometriosis is still in its infancy, and MRI only helps to…
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Understanding what we see: endometriosis laparoscopic appearance and microscopic verification
By Nasuhi Engin Aydin
Chia-Sui Weng and colleagues from the Mayo Clinic, USA have published their results on laparoscopic appearances and microscopy of endometriotic lesions in “The Journal of Minimally Invasive Gynecology”. Even though the diagnosis of endometriosis has evolved greatly with advanced imaging…
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Rhein usage in endometriosis: A potential new therapeutic agent
By Eylül GÜN
The invasive nature of endometriosis has prompted scientists to find preventative and curative methods. The progression and proliferation of endometriotic lesions are being studied extensively. As one of the agents used in Chinese herbal medicine for inflammatory disorders, rhein is…
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Organizing structural protein Ezrin and its active form in endometriosis biopsies
By Nasuhi Engin Aydin
Dr. Alessandra Peloggia and colleagues from Brazil have published their results on immunostaining of Ezrin protein and its phosphorylated active form in endometrial tissues in a recent issue of “Clinics” Possible factors on endometrial cell implantation and proliferation in the…
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A prediction model to identify endometriosis during routine ultrasound .
By Selma Oransay
. Ureterolysis is an advanced surgical technique that involves dissection of the ureter from pelvic brim to the ureteric tunnel to avoid injury or freeing the ureter from endometriotic lesions. This manipulation usually requieres advanced surgical training and skill. In…
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T-cell-targeted immunotherapy and immune checkpoint inhibitors for the treatment of endometriosis
By Nasuhi Engin Aydin
Dr. Monika Abraimuk and colleagues from Poland published their review on "the importance of immunity in endometriosis" in a recent issue of the medical journal “Cellular Signaling”. A great challenge in contemporary medical issues is endometriosis which still lacks a…
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Do endometriosis patients have increased risk of stroke?
By Nasuhi Engin Aydin
Dr. Leslie V. Farland and colleagues from the University of Arizona, published their prospective research on the risk of stroke in women with laparoscopically confirmed endometriosis in a recent issue of a scientific journal named “Stroke”. Endometriosis is a chronic…
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To Remove the Ovary(ies) or Not During Hysterectomy for Endometriosis
By Selma Oransay
Some surgeons prefer empiric bilateral salpingo-oophorectomy during the hysterectomy of women with endometriosis based on the knowledge that endometriosis is stimulated by endogenous estrogens, as leaving the ovaries in situ may increase the possibility of endometriosis recurrence and pelvic pain.…
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The effect of postoperative hormonal medication preferences on the recurrence rate of endometrioma
By Bahar Yuksel
Endometrioma is the most investigated type of endometriosis. The recurrence after surgery is important regarding its and reoperation’s effect on ovarian functions. In the study conducted by Seung-Hye Choi et al, the researchers questioned the effect of different postoperative hormonal…
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The effects of resveratrol on endometriotic cells
By Eylül GÜN
The current treatment methods for endometriosis still carry recurrence risks and side effects from medications. Herbal medicine has been investigated and used as an additional alternative method. Derived from several plants and found in some dietary sources, resveratrol is a…
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The best method for the diagnosis of endometriosis: SEE and BELIEVE
By Eylül GÜN
Deciding on the best diagnostic procedure for endometriosis patients has been a recent subject of debate. While some clinicians believe non-invasive methods such as imaging and symptom-based treatment should be the choice in the diagnosis, some believe the best method…
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Validity of Magnetic Resonance Imaging for Deep Pelvic Endometriosis.
By Selma Oransay
Video laparoscopy has become a valuable tool for diagnosing and managing endometriosis in recent years. In cases associated with deep infiltrating endometriosis, the need for a non-invasive diagnostic method before laparoscopic evaluation paves the way for using MRI. The use…
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Start exercising for pain relief
By Bahar Yuksel
Physical exercises have always been suggested for chronic pain-related diseases as well as endometriosis. However, the effect of exercise and the frequency that is effective on pain relief is unknown. In the study conducted by Ipek Ensari et al, a…
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Genomic evidence: The recognition of endometriosis as an inflammatory systemic disease
By Nasuhi Engin Aydin
Dr. Bao and associates from Shangai-China published a new article on the genomic features of endometriosis that could yield information on its inflammatory basis and possible therapeutic potential in a recent issue of “Frontiers ın Immunology”. Endometriosis is a systemic process…
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Evaluation of retrocervical and parametrial deep endometriosis by detailed ultrasonography
By Selma Oransay
The accuracy of ultrasonographic diagnosis of deep endometriosis in the retrocervical and parametrial areas may be poor due to the variable morphology of endometriotic lesions, the complex structure of the posterior parametrial compartment, and the difference in examiners' experience level.…
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Is it possible to reduce pain by diet in endometriosis?
By Eylül GÜN
Endometriosis-related pain is one of the most common symptoms of endometriosis that significantly affects the patient's quality of life. The peripheral and central sensitization, caused by chronic inflammation activation, may result in referred pain. The pain perception was shown to…
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A new potential therapeutic target in endometriosis: Galectin-3
By Eylül GÜN
The endometrial cells migrate and attach to the peritoneal surface according to the most widely accepted retrograde menstruation theory in endometriosis development. Given that only 10% of women have endometriosis, it is thought that some additional factors contribute to the…
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Understanding the expression of endometriosis-related pain: A barrier to overcome
By Eylül GÜN
It is difficult to describe the feeling of pain, one of the most important symptoms of endometriosis because it is subjective. Endometriosis-related pain is proven to be underestimated by some clinicians resulting in the patient getting a late diagnosis. It…
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Soluble CD90 : a potential serum biomarker in endometriosis
By Nasuhi Engin Aydin
Dr. Bochev and colleagues from several medical centers in Bulgaria published their research on the role of a possible serum biomarker in diagnosing endometriosis in a recent issue of the journal named “Disease Markers”. The definitive diagnosis of endometriosis, an…
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The accuracy of transvaginal ultrasound and magnetic resonance imaging for deep urinary tract endometrisis.
By Selma Oransay
The prevalence of urinary tract endometriosis is 19-53% in patients within deep infiltrating endometriosis cases. The bladder and ureteral are the most common sites of the involvement. While preparing a radical surgery for a patient with deep endometriosis, the diagnosis…
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Chronic pelvic pain and endometriosis
By Selma Oransay
Patients may have an average of 7 clinical visits before being diagnosed with endometriosis. Understanding chronic pain conditions including endometriosis-associated pain, and developing chronic pelvic pain benefits the management of the patients. The role of central sensitization, comorbid conditions, and…
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Who Is Diagnosing my Endo?
By Özge Özkaya
It is possible to acquire the skills necessary to diagnose endometriosis lesions as well as adenomyosis using three-dimensional rectosonography after a short learning period in an expert radiology center. This is according to a new study by French researchers published…
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Does inhibiting the formation of the new blood vessels aid in endometriosis treatment?
By Eylül GÜN
Current treatment modalities for endometriosis include a hormonal alteration which has many side effects and surgical removal which has a high postoperative recurrence rate. Alternative non-hormonal treatment methods have been investigated and anti-angiogenic therapy is one of them. Dr.s Chung…
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Adenomyosis Increases Risk of Surgical Complications
By Özge Özkaya
Adenomyosis increases the risk of deep endometriosis surgery complications, according to a new study published in the journal Scientific Reports. Patients with deep endometriosis and adenomyosis should therefore be informed about this risk before undergoing surgery. Adenomyosis occurs together with…
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Comparison of imaging techniques for estimating the depth of bowel wall infiltration by endometriosis.
By Selma Oransay
The surgical removal of deep endometriosis is the cornerstone of the management. However, the decision for the varying surgical approach types ranging from conservative management (shaving) to segmental or discoid resection depends on the depth of infiltration within the bowel wall, which…
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Prevalence of endometriosis and adenomyosis by transvaginal ultrasound.
By Selma Oransay
Women who present dyspareunia, dysmenorrhea, dysuria, dyschezia, chronic abdominal, and pelvic pain, and infertility would benefit from the early investigation. If the correct diagnosis of endometriosis and/or adenomyosis can be made in advance, early treatment will improve the quality of…
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Non-invasive diagnostic tools for endometriosis revisited
By Nasuhi Engin Aydin
Dr. Signorile and associates from the Italian Endometriosis Foundation have published the results of their retrospective study on a large cohort of endometriosis patients in a recent issue of the periodical, In Vivo. Endometriosis lacks precise scientific knowledge and this brings…
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The underlying reason of implantation failure in women with endometriosis-associated infertility
By Hale Goksever Celik
Endometriosis is most frequently encountered in reproductive-aged women, with a prevalence of 10-15% in the general population. However, endometriosis is more frequently diagnosed in infertile women, with a prevalence of 25-40%. Although the exact mechanism explaining the association between endometriosis…
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Immunotherapy in endometriosis: a challenging research topic
By Nasuhi Engin Aydin
Dr. Maksym and associates from academic centers in Poland have published their comprehensive review on endometriosis emphasizing the immunological aspects of the disease in a recent issue of the "Journal of Clinical Medicine". Even though endometriosis is a multifactorial disease,…
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Is "non-hormonal therapy" effective in women with endometriosis-associated pain?
By Hale Goksever Celik
Women with endometriosis require effective treatment due to the negative impact of the disease on quality of life. Hormonal treatments including oral contraceptives, and progestins are usually recommended to suppress ovulation and decrease pelvic pain. However, some women do not…
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Surgery for the Treatment of Endometriosis of the Diaphragm and Thorax
By Özge Özkaya
Diaphragmatic and thoracic endometriosis starts in the abdominal wall of the diaphragm and later invades the thorax, based on findings from a series of patients surgically treated for the disease, reports a study published in the Journal of Gynecology Obstetrics…
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Diaphragmatic defects, liver herniations and catamenial pneumothorax
By Nasuhi Engin Aydin
Dr. Arakawa and associates from The Jikei Katsushika Medical Center, Japan, have published their recent case of catamenial pneumothorax with diaphragmatic defect and liver herniation in the "Journal of Cardiothoracic Surgery". Catamenial pneumothorax is an uncommon condition with a reported…
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Endometriosis of the Diaphragm, What do the Doctors Know About it?
By Özge Özkaya
The median time between the first consultation with a primary care physician and receiving a diagnosis of endometriosis of the diaphragm is two years according to a study by U.K. researchers. In the worse case, it took 23 years for…
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Diaphragmatic endometriosis
By Selma Oransay
Diaphragmatic endometriosis is a rare clinical condition that may show signs and symptoms like chest pain, right upper quadrant abdominal pain, shoulder pain, pleuritic pain, hemothorax, pneumothorax, hemoptysis, and thoracic endometriosis syndrome while the major part of the patients is…
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Thoracic endometriosis: the most frequent endometriosis involvement outside abdominopelvic cavity
By Nasuhi Engin Aydin
Six to ten percent of reproductive-age women are affected by endometriosis, and about 12% are estimated to be outside the abdominopelvic cavity - the most frequent location being the thorax. Endometriosis within the pulmonary parenchyma or on the diaphragm and…
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Urinary Tract Endometriosis
By Bahar Yuksel
Endometriosis is mostly seen in patients of fertile age, and urinary tract endometriosis affects 1.2 to 6% of women with endometriosis. French coloRectal Infiltrating ENDometriosis Study (FRIENDS) group investigated the characteristics of urinary tract endometriosis in 232 patients from 31 centers. Authors…
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Nerve-sparing technique for deep infiltrating endometriosis and its impacts on pelvic organ and sexual functions.
By Selma Oransay
Deep infiltrating endometriosis and involvement of parametrium cause severe pelvic pain and dysfunction of some pelvic organs resulting in a reduction in women's quality of life. Although surgery for DIE aims to relieve pelvic pain, entering into the posterior parametrial…
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Endometriosis: Beyond the naked eye visibility
By Bahar Yuksel
The gold standard method for endometriosis diagnosis is histopathologic evaluation of the resected lesions. The study conducted by Sara-Michelle Gratton et al. in Canada evaluated the possible effect of developed laparoscopic skills and equipment on the endometriosis diagnosis, and whether…
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The necessity of laparoscopy for unexplained infertility.
By Selma Oransay
The standard for accepting a couple as "infertile" is the inability to conceive after 12 months of regular unprotected intercourse. When this condition is met, assessing the number of motile sperm in the male partner and certifying the patency at…
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From Spain: execution for endometriosis and chronic pelvic pain unresponsive to conventional therapies
By Selma Oransay
The current conventional therapy for chronic pelvic pain for endometriosis is defined as either hormonal or non-hormonal medical treatment starting with combined oral contraceptives progestins or dienogest, and then gonadotropin-releasing hormone analogs and/or surgery. Although conventional therapies usually are successful, still…
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The higher the Endometriosis Fertility Index, the higher the chance of getting pregnant
By Hale Goksever Celik
The women who desire to get pregnant may also suffer from fertility problems depending on several mechanisms such as anatomic distortion, peritoneal adhesions, tubal dysfunction, impaired quality of oocytes, and impaired endometrial receptivity. One of the most important problems in…
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New Endometriosis Clinical Trial Now Recruiting Participants
By Özge Özkaya
A new clinical trial investigating the effect of cognitive-behavioral therapy on quality of life in patients undergoing surgery for endometriosis is now recruiting participants. The randomized, controlled trial aims to recruit 100 participants, ages 18 to 50 with proven endometriosis…
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Is it the new gold mine for endometriosis: oral GnRH antagonists
By Bahar Yuksel
Progestins and combined oral contraceptive pills are the first step hormonal options for women with endometriosis. But the more the use expands the more cases are seen with resistance to progestins. This gave birth to a need for different therapeutic…
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The effect of hormone therapy after surgical menopause on endometriosis recurrence
By Selma Oransay
Definitive surgery for severe and advanced endometriosis is hysterectomy with bilateral oophorectomy, which may cause vasomotor symptoms, sleep deprivation, mood change, and dyspareunia in the patients. Furthermore, after the surgical removal of the ovaries, the sudden drop in estrogens causes…
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Does Surgery Improve the Digestive Symptoms of Endometriosis?
By Özge Özkaya
Women with deep infiltrating endometriosis involving the bowels have the most significant improvement in gastrointestinal symptoms following surgery. This is according to the findings of a comparative retrospective study in almost 1,500 women. “Women with severe bowel symptoms and deep…
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Inflammatory and genetical background of endometriosis may yield new therapeutic approaches
By Nasuhi Engin Aydin
Elisa Giacomini and colleagues from medical centers in Milan, Italy have published their review manuscript on the inflammatory and genetical pathogenetic background of endometriosis in a recent issue of “International Journal of Molecular Sciences”, suggesting also new therapeutic approaches. The inflammatory…
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Molecular alterations in endometriosis pathogenesis
By Eylül GÜN
Endometriosis has been in our lives for decades, however little is known about its pathogenesis making it hard to diagnose and manage. A review study conducted by Balasubramanian et al. from India reveals all the characteristics and the underlying conditions…
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Urinary Function Alterations after Surgery for Deep Endometriosis.
By Selma Oransay
Laparoscopic surgery is a mainstay therapy for symptomatic patients with DE. Although our findings of improvement in many domains of urinary function are encouraging, postoperative deterioration in urinary function was found for patients with initial normal function. More research is…
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The comparison of the effect of hemostatic techniques on ovarian reserve during endometrioma cystectomy
By Hale Goksever Celik
The possible negative effect of the surgical excision of endometriomas on the ovarian reserve has brought up the meticulous implementation of the decision for surgical approach. Dr. Raquel Silveria da Cunha Araujo et al, from Brazil, published a study titled as…
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How to Reduce Pain After Laparoscopic Surgery
By Özge Özkaya
Using humidified warm gas with forced-air warming blanket during laparoscopic surgery resulted in significantly less pain in the recovery room, according to a new study published in the journal "Surgical Endoscopy". In patients with endometriosis, using humidified warm air even…
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Impact of surgery before IVF in infertile women with endometrioma
By Hale Goksever Celik
Among the women with endometriosis, 30 to 50% are estimated to have infertility. On the contrary, among women who present with infertility, 25 to 50% are estimated to also have endometriosis. Several mechanisms have been proposed to explain the association…
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Best practice: How to reduce intraoperative bleeding?
By Selma Oransay
Although laparoscopic hysterectomy is a popular and common approach for removing benign uterine lesions, some technical steps especially concerning uterine artery closure depend on the surgeon's preference. Uterine artery ligation may be performed either at the uterus level, which is common…
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A rare complication of endometriosis
By Selma Oransay
Morales et al. from the Monterrey School of Medicine, Mexico, reported a case of bowel intussusception in a woman with severe endometriosis to draw attention to this very rare endometriosis complication. The case is a 27 years old young female…
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Research Identifies New Genes That Could Be Targeted to Treat Endometriosis
By Özge Özkaya
Researchers identified three new genes that could help understand the invasiveness of endometriosis. They also identified one new gene that could be related to the recurrence of the disease. These genes may potentially be new therapeutic targets for endometriosis. In…
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The added value of transvaginal hydro-laparoscopy for infertile women
By Selma Oransay
The added value of invasive diagnostic laparoscopy has been questioned, postponed by the increased usage of ultrasonography for the evaluation of infertile patients. Gordts et al. from Life Expert Center, Leuven, Belgium have been working on an alternative way called "transvaginal hydro-laparoscopy" to…
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Transvaginal Ultrasound Accuracy for Uterosacral Ligament, Torus Uterinus and Posterior Fornix Endometriosis
By Selma Oransay
The accuracy of transvaginal ultrasonography for the diagnosis of deep endometriosis depends on the location. The sensitivity is up to 80% when the lesion is in the rectosigmoid, but it decreases up to 66% for the detection of posterior vaginal…
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How to measure the length of recto-sigmoid deep endometriosis reliably?
By Eylül GÜN
An in-depth assessment is needed when rectosigmoid deep endometriosis is decided to be treated surgically. Surgery carries a lot of risks and it is not always easy to decide which procedure the patient would benefit the most from. Patient-oriented surgical…
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Strong Geographical Gradient in Endometriosis Incidence Identified
By Özge Özkaya
The geographical distribution of new endometriosis cases showed a very strong north-south spatial gradient in the highly industrialized Friuli Venezia Giulia region of Italy, according to a new study published in the International Journal of Environmental Research and Public Health. “The cluster of…
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Promising therapeutic results in experimental endometriosis model
By Nasuhi Engin Aydin
Tiziana Genovese and associates from Italian academic centers reported their pioneering findings in an experimental model of endometriosis administering an anti-tumor agent and glucocorticoid combination, published in the scientific periodical “International Journal of Molecular Sciences”. Endometriosis is a worldwide common disease…
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Analyses of the main classification systems of endometriosis in terms of utrasound, MRI and surgery
By Selma Oransay
Several classifications made by gynecologists, image readers, and radiologists lead to confusion while describing the situation and estimating the progress of endometriosis. Daniela Fischerova team from the Charles University of Prague, Czech Republic, analyzed the main classifications of endometriosis in three…
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A hot research topic: macrophage reprogramming for endometriosis treatment
By Nasuhi Engin Aydin
Daria Artemova and colleagues from several research institutes of the Russian Federation have published their review on the cellular aspects of endometriosis related to macrophages, particularly emphasizing promising therapeutic options for the future in "International Journal of Molecular Sciences". Macrophages have…
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A pictorial overview of abdominal wall endometriosis
By Hale Goksever Celik
Abdominal wall endometriosis is the most frequent location of extrapelvic endometriosis, and defined as the presence of ectopic endometrial tissue between the peritoneum and the skin through the abdominal wall. Although obstetric or gynecologic surgical history is indispensable for the…
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New molecular insights in endometriosis pathogenesis
By Nasuhi Engin Aydin
Dr. Rosalba Siracusa and associates from Messina University, Italy, have published their research on cellular pathogenesis of experimental endometriotic lesions in the recent issue of the "International Journal of Molecular Sciences". Endometriosis is a debilitating chronic estrogen-dependent inflammatory condition and…
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Outcomes of chronic pelvic pain of endometriosis after laparoscopic surgery
By Selma Oransay
The prevalence of endometriosis is up to 35-50% among patients with pelvic pain. Among several medical and surgical options to relieve chronic pelvic pain, surgical options are the preferred method but this depends on patients' age, fertility desire, and disease…
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Postoperative ovulation induction in infertile women with minimal to mild endometriosis
By Hale Goksever Celik
Infertility is an important problem that is encountered in 30-50% of women with endometriosis. Several etiopathogenetic mechanisms for the development of reproductive problems in women with endometriosis have been proposed including abnormal peritoneal microenvironment, ovarian dysfunction and/or decreased oocyte quality,…
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Ultrasonographic signs of adenomyosis, surgery and infertility in endometriosis patients
By Bahar Yuksel
Adenomyosis is simply defined as the presence of endometrial glands and stroma within the uterine myometrium and is related to severe menstrual bleeding, pain, and infertility. Previous reports demonstrated the coexisting of endometriosis and adenomyosis is common. In the present…
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The Surgical Management of Endometriosis of the Ureter and Bladder
By Özge Özkaya
Laparoscopic surgery is feasible and safe to manage endometriosis of the ureter and bladder, according to a new study published in the Journal of Minimally Invasive Gynecology. According to the authors of the study, ureteral resection is more strongly associated…
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Evaluation of preoperative risk factors of ureteral endometriosis
By Selma Oransay
Endometriosis affects the urinary tract in 1% to 5.5% of the patients, and among them, bladder involvement is 70-85%, while ureteral involvement alone is 9% to 23%. Ureteral endometriosis is most commonly unilateral, especially on the left side, usually affecting…
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Endometriosis Surgery Improves Sex Life
By Özge Özkaya
Women who underwent laparoscopic resection surgery to treat their deep infiltrating endometriosis had improved sexual quality of life and health-related quality of life according to a new study published in the Journal of Minimally Invasive Gynecology. These findings are important…
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Postoperative infertility management using Endometriosis Fertility Index in endometriotic women
By Selma Oransay
"Endometriosis Fertility Index '' score, described by the World Endometriosis Society in 2017, is a robust score and assists to predict the spontaneous pregnancy rate of women with endometriosis, within 3 years after their operation. Its calculation is possible by patient…
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What Happens to Endometriosis Patients After Endometriosis Surgery?
By Özge Özkaya
Although few patients with endometriosis who undergo a hysterectomy need repeat surgery, up to 25% of them need minor surgery. Around 20% of patients who undergo conservative surgery with ovarian preservation require additional endometriosis surgery. Up to one in three…
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Endometriosis in intestine! Segmental resection or linear nodulectomy?
By Bahar Yuksel
Intestinal involvement of endometriosis is common, and the incidence was defined between 45-56%. Previous studies investigating the role of surgery in the management of intestinal endometriosis reported improvement of life quality in up to 95% of cases following surgery. However,…
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The association of chronic endometritis, endometriosis and tubal infertility
By Selma Oransay
Holzer et al. from the Department of Gynecologic Endocrinology and Reproductive Medicine of Medical University of Vienna, Austria, set up apilot prospective cohort study to evaluate the relationship between chronic endometritis, infertility and endometriosis. The results of the study were recently…
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Improvement of the quality of life after surgery for deep infiltrating endometriosis.
By Selma Oransay
Deeply infiltrating endometriosis is the most severe form among the endometriosis types. The required laparoscopic approach is the appropriate excision of endometriotic foci from pelvis, by consideration of failure and side effects of the medical treatments. The specialist endometriosis centers…
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Problems in the treatment of deep infiltrating endometriosis
By Bahar Yuksel
The Deep Infiltrating Endometriosis (DIE) is very aggressive in nature with infiltrating the whole pelvic, colon, rectum, bladder, ureter, and pelvic wall. D’Alterio and colleagues analyzed the advantages and disadvantages of both medical and surgical therapies for DIE. The authors…
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Postoperative long-term estro-progestin therapy for endometrioma
By Selma Oransay
After the removal of ovarian endometriomas, the major concern is the high recurrence rate of symptoms and endometriotic cysts. The estimated recurrence rate of endometriomas is up to 50% at 5 years after surgery. To prevent the recurrence, postoperatively long-term…
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Adenomyosis: accuracy of the diagnostic methods and the synchronism with deep infiltrating endometriosis
By Nasuhi Engin Aydin
Dr. Alborzi and associates from Shiraz University of Medical Sciences, Iran, have published their comprehensive retrospective research conducted on 3725 patients with clinical symptoms of endometriosis over a period of 3 years, in "Reproductive Sciences" medical journal. A relationship between…
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Postoperative treatment and pregnancy points to decreased recurrence risk for ovarian endometriosis
By Hale Goksever Celik
Endometriosis is a disease most frequently diagnosed in women of reproductive age and negatively affects the quality of life. The most common localization for endometriosis is ovaries with a prevalence of 17-44%. Laparoscopic ovarian cystectomy performed as excision or ablation…
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Controlled use of bipolar cauterization as an alternative to endometrioma cystectomy
By Hale Goksever Celik
The main symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Ablation or coagulation of the cyst wall following laparoscopic drainage of endometrioma may be an alternative treatment for patients with pregnancy intention. Carbon dioxide, laser, and plasma energy…
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Managing the physical and emotional effects of endometriosis
By Hale Goksever Celik
Endometriosis is known to affect 5-10% of the general population, but some women are underdiagnosed due to physical and psychological disability. Due to the symptoms including dysmenorrhea, dyspareunia, chronic pelvic pain and infertility, endometriosis has a negative effect on the quality…
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Oxygen deprivation (hypoxia) has a critical role in the pathogenesis and progression of endometriosis
By Nasuhi Engin Aydin
Dr. Wan-Ning Li and associates from academic institutions from Taiwan have published their review paper on the role of hypoxia and possible therapeutic outcomes in the medical journal named "Reproduction" recently. Endometriosis is an important ailment with huge medical and social…
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Endometriosis and the risk of Systemic lupus Erythematosus: A report from Taiwan
By Selma Oransay
Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage that affects mostly women, with an M:F ratio of 1:9. Recent evidence has also shown that endometriosis is…
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By Yu Yu"Complement" of immune system and endometriosis therapeutics
By Yu Yu
The complement system is part of the body’s immune system, and plays integral roles in the recognition and clearance of pathogens, apoptotic and necrotic cells. It is composed of over 50 proteins with soluble activation precursor components, regulators and cell…
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By Dr. Youngran ParkNanomedicines for Endometriosis
By Dr. Youngran Park
Scientific research on nanoparticles is intense as they have many potential applications in medicine. Nanomaterials have been widely explored for imaging and treatment of various diseases, especially cancer, over the recent twenty years. The absence of non-invasive diagnostic tests and…
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The improvement of fertility rate and symptoms of superficial endometriosis following laparoscopic peritoneal stripping
By Selma Oransay
Pain, in the form of diverse entities, including dyspareunia, dysuria, dyschezia, is the main symptom of endometriosis patients. The severity of pain is independent of the extent and the location of the disease, and generally causes a negative impact on…
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Vitamin D supplementation, endometriosis symptoms and metabolic profiles
By Hale Goksever Celik
Patients with endometriosis suffer from dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. These women are also at higher risk for ovarian and breast cancer, cardiovascular events, and metabolic abnormalities. Several medical and surgical alternatives have been recommended to these patients…
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The role of hormonal treatment after endometriosis surgery
By Bahar Yuksel
Postoperative hormonal suppression after endometriosis surgery still does not have a uniform approach. The meta-analysis study conducted by Zakhari et al. aimed to find a significant answer regarding this burden. They analyzed the database systems including MEDLINE, Embase, Cochrane CENTRAL,…
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"Speckle sign": a novel transvaginal ultrasound finding for posterior compartment endometriosis
By Nasuhi Engin Aydin
Dr. Balcacer and associates from three medical institutions located in the USA report the results of their retrospective study on deep infiltrating endometriosis utilizing transvaginal ultrasound examination and the proposed “speckle sign” in the "Journal of Ultrasound Medicine". Pelvic ultrasound…
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By Irem OnurAnalysis of women with endometriosis-related pain before the multidisciplinary endometriosis care management
By Irem Onur
Endometriosis patients are generally treated by a single provider and they frequently report dissatisfaction with care. To decrease diagnostic delays, improve pain management, and promote patient satisfaction, multidisciplinary endometriosis centers emerged. But, baseline data assessing the efficacy of the multidisciplinary…
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Laparoscopic Approach to Rectus Muscle Endometriosis and Inguinal Endometriosis - Ted Lee, MD
By Selma Oransay
Rectus muscle endometriosis and inguinal endometriosis are two rare types of endometriosis. Operation room videos of several patients with different rectus muscle endometriosis and inguinal endometriosis are shared during the presentation of Dr. Lee to clarify the methods of the…
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Exploring Pelvic Pain: Deep to Ischial Spine Including Pre-Sacral Roots - A. Taner Usta, MD
By Irem Onur
Chronic pelvic pain is defined as pain in the pelvic area that lasts for 6 months or longer and results in functional or psychological disability or requires intervention and treatment by the American College of Obstetrics and Gynecologists. There are…
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By Ellen TumimbangWhy Persistent or Recurrent Endometriosis Happens? - Dan Martin, MD
By Ellen Tumimbang
The objectives of Dr. Martin in this presentation are to understand the difficulties in recognition of deep and hidden endometriosis, difficulties in recognition of small lesions of micron size, and differentiate the look-alike lesions of endometriosis. He addressed overcoming these…
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Fixing holes: prevention and treatment of complications - Jon Einarsson, MD, MPH
By Selma Oransay
Dr. Einarsson shared his operating room video screens during his speech for discussing four major complications (ureter, bladder, bowel, and vascular) of endometriosis surgery and the ways to repair them. Fixing the ureter damage: Endometriotic nodules may settle on the tract…
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Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD
By Selma Oransay
The removal of endometrioma may affect ovarian reserve because healthy follicles near endometrioma could also be excised during this procedure. Another concern about the ovarian reserve is that it may be already low before the surgery. Anti Mullerian Hormone (AMH)…
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A Possible genetic target for endometriosis treatment
By Dr. Youngran Park
Mutations in the chromosome remodeling complex SWI/SNF subunit ARID1A were first identified in ovarian clear-cell carcinoma and ovarian endometrioid carcinoma, two endometriosis-associated epithelial ovarian cancer subtypes. ARID1A gene mutations are also observed in deep ovarian and deep infiltrating endometriosis, atypical endometrial…
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The recurrence risk of endometrioma in older age
By Bahar Yuksel
Ovarian endometrioma is more common in reproductive ages and the recurrence rate is around 20 percent in the first 2 years after the initial surgery. The use of postoperative hormonal therapy is a mutual option to decrease recurrences. The rate…
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Endometriosis and Inflammation: How to Treat it?
By Özge Özkaya
Women with endometriosis have systemic and localized inflammation within eutopic and ectopic endometrial tissues found in a study published in the "American Journal of Reproductive Immunology". More importantly, the study also found that the inflammation caused by the disease could…
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Endometrioma size and anti-Müllerian hormone levels
By Hale Goksever Celik
Endometriotic lesions are encountered in different locations in the pelvic cavity, including but not limited to the ovaries, the pouch of Douglas, the ureters, the bladder, and the bowel. Cystic endometriosis lesions located in the ovary are called "endometrioma". Endometriomas have…
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Comparison of diagnostic accuracy of imaging modalities for the deep infiltrating endometriosis
By Selma Oransay
The treatment of deeply infiltrated endometriosis (DIE) is usually personalized and the potential success for the available therapeutical options is dependent on early and accurate diagnosis. Laparoscopy is the gold standard for the diagnosis of DIE. Other non-invasive diagnostic methods…
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Bad bad lipid go away!
By Yu Yu
Much like the progression of endometriosis, accumulating evidence suggests that systemic chronic inflammation and oxidative stress can contribute to atherosclerosis. The excess low-density lipoprotein increases inflammatory processes in the arteries, which may result in atherosclerosis. Previous studies have shown that…
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It is time for non-invasive tests for peritoneal endometriosis diagnosis
By Nasuhi Engin Aydin
Maria Szubert with colleagues from Lodz Medical University, Poland, investigated the possibility of potential diagnostic biomarkers in the eutopic endometrial tissue from peritoneal endometriosis patients and published their results in the "Journal of Gynecology Obstetrics and Human Reproduction". Currently, diagnostic…
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Endometriosis-related obstetrical complications and their outcome
By Selma Oransay
Borisova et al. from the Department of Gynecology and Obstetrics of Peoples' Friendship University, Moskow, Russia, and her colleagues from the Center of Perinatal and Reproductive Medicine of University Perugia, Italy, recently published a review of the literature data about…
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Time for reassessment : Laparoscopic surgery and bowel endometriosis
By Nasuhi Engin Aydin
Ferrero and associates from medical centers of Verona and Genoa, Italy, made a comprehensive review covering all aspects of the surgical approach to bowel endometriosis, published their results in "Best Practice & Research Clinical Obstetrics and Gynaecology". Bowel endometriosis is the…
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Deep Endometriosis or Recto-uterine Obliteration Without Endometrioma
By Selma Oransay
The diagnostic help of ultrasound is increasing by its ability to diagnose deep infiltrating and rectouterine pouch obliteration in patients who are suffering from chronic pelvic pain. Clinicians are used to evaluating the rectal and parametrial areas of the endometriotic…
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The advantages of combined vaginal-laparoscopic approach on voiding dysfunction for rectovaginal endometriosis
By Irem Onur
The patients with rectovaginal endometriotic nodules with extensive vaginal infiltration who are managed combined vaginal-laparoscopic approach have a lower risk of postoperative bladder dysfunction when compared to surgery via laparoscopy alone. This is according to a manuscript published in the…
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Endometriotic mesenchymal stem cells may promote endometriosis
By Yu Yu
The cause of endometriosis is still debatable. Many researchers have accepted that retrograde menstruation, where the endometrial fragments released during menstruation attach and colonize the ectopic locations, is the most plausible reason. However, the numbers just do not add up.…
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Natural history of spontaneous endometriosis in crab-eating monkeys
By Nasuhi Engin Aydin
Kaori Hayashi and associates from Shiga University of Medical Science, Japan, published their observations on spontaneously occurring endometriosis in crab-eating monkeys in "Tohoku Journal of Experimental Medicine"https://www.jstage.jst.go.jp/article/tjem/251/4/251_241/_pdf/-char/en. The presence of endometrial tissue outside the uterus, i.e., endometriosis is a progressive prevalent…
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Endometriosis prevalence among adolescents with pelvic pain
By Irem Onur
An updated review conducted by the investigators at EGA Institute for Women's Health, University College London, United Kingdom, in collaboration with Birmingham Women’s and Children’s Foundation Trust of the Institute of Metabolism and Systems Research at the University of Birmingham…
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Hormone Therapy Before Endometriosis Surgery
By Yu Yu
Hormonal therapy can be effective for endometriosis, although laparoscopic surgery is required for the frequent drug-resistant symptoms. Laparoscopic surgery can markedly improve endometriosis-associated pain. The administration of GnRH agonist prior to endometriosis laparoscopic surgery may be beneficial to improve surgical…
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By Nadire DuruClinical characteristics linked to recurrence of ovarian endometrioma
By Nadire Duru
Endometriosis affects 10-15% of women. Three types of endometriosis are peritoneal, ovarian, and deep infiltrating endometriosis. Ovarian endometriosis is the most common type of endometriosis with a high rate of recurrence. Laparoscopy is the gold standard treatment for endometriosis and…
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The impact of obesity on safety and feasibility of laparoscopic endometriosis surgery
By Hale Goksever Celik
The quality of life in the women affected by endometriosis depends on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. The most common locations of endometriosis are ovary, ovarian fossa, uterosacral ligament, and…
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Suggested remedies for endometriosis patients during coronavirus pandemic
By Nasuhi Engin Aydin
The pandemic of COVID-19 continues to have important effects on endometriosis patients worldwide. Many health care facilities stopped providing surgical management and outpatient appointments are canceled or postponed. Dr. Leonardi from Australia and associates from several countries published their proposals…
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Occult microscopic endometriosis in clinically negative peritoneum
By Irem Onur
Occult microscopic endometriosis may be present in approximately 39% of patients with clinically negative appearing peritoneum undergoing laparoscopy for chronic pelvic pain. This finding is presented in a study published online this month in the International Journal of Gynecology &…
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Adolescent dysmenorrhea diagnosis and management
By Hale Goksever Celik
Endometriosis is usually diagnosed in reproductive-aged women. However, recent literature proved that clinical symptoms of endometriosis are also seen the adolescent girls and young women. Dysmenorrhea, the most common gynecologic complaint among this age group, can develop due to endometriosis.…
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By Murat OsmanDiagnosing Deep Endometriosis Using Transvaginal Elastosonography
By Murat Osman
Deeply infiltrating endometriosis (DIE) is an advanced form of endometriosis that causes significant morbidity to a large number of women. Early detection of endometriosis is imperative for early treatment and improved outcomes for these patients. Currently, transvaginal ultrasound (TVUS) and magnetic…
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A hope for postoperative symptomatic endometriosis therapy
By Irem Onur
A new chapter in the treatment of symptomatic endometriosis patients may begin since new medical approaches including oral GnRH antagonists, selective progesterone receptor modulators, aromatase inhibitors, and peritoneal immune response modulators are being actively evaluated. To date, there was only…
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Diagnosis and treatment algorithm for endometriosis
By Selma Oransay
Endometriosis is a chronic and progressive disease that affects 25-30% of women between 25-35years, clinicians commonly experience during their gynecologic practice. However, the diagnosis is still late or sometimes incorrect, and this creates severe health problems and worse outcomes. A…
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Endometriosis by Race
By Hale Goksever Celik
Endometriosis is usually diagnosed in reproductive-aged women with an incidence of approximately 10%. The most common presenting symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility in patients with endometriosis. Some risk factors have been identified for the development of…
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Endometriosis surgery and future pregnancy complications
By Selma Oransay
Endometriosis is one of the known diseases for infertility in the reproductive period of women. Several studies revealed that endometriosis itself maybe the reason for some unfavorable obstetric outcomes. Localization, the type of endometriotic lesions, and the stage of endometriosis…
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Risk Factors Associated with Ureteral Endometriosis
By Özge Özkaya
Patients with severe endometriosis, uterosacral ligament deep involvement with endometriosis lesions of 3 cm in diameter or more, and the presence of previous endometriosis surgery have a significantly higher risk of having ureteral endometriosis. This is according to a study…
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Laparoscopic surgery for COVID-19 positive patients: A Dilemma
By Nasuhi Engin Aydin
COVID-19 pandemic is the most important issue of our days. In this regard, it is crucial to keep health care providers (HCPs) safe and away from contamination. Doctors Without Borders reported that regardless of all preventive measurements, nearly eight percent…
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Postmenopausal endometriosis: Is it a rare phenomenon?
By Hale Goksever Celik
Endometriosis, the estrogen-dependent disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity, is generally diagnosed in the reproductive-aged women. However, recent literature proved that this disease can also be observed in the premenopausal and…
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Improved fusion imaging for the detection of Endometriosis
By Murat Osman
This paper studied a new fusion method for magnetic resonance (MR) and ultrasound (US) imaging for the appropriate diagnosis of endometriosis. The diagnosis of endometriosis in patients with a chronic pelvic disease is delayed, due to the disease, patient, and physician-led…
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Appendiceal endometriosis
By Selma Oransay
Jeong et al. from the Departement of Surgery, Trinity School of Medicine, Saint Vincent, recently published their interesting appendectomy case in "Hong Kong Medical Journal". In their case, endometriosis inside the cavity of the appendix mimicked appendicitis, the patient submitted…
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Hysterolaparoscopy Plus Assisted Reproduction Improves Fertility in Women with Endometriosis
By Özge Özkaya
Hysteroscopy and laparoscopic surgery is an effective and reliable therapeutic procedure, confirmed a study published in the "Journal of Clinical Medicine". The approach is even more effective when combined with assisted reproductive techniques such as artificial insemination and in vitro…
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By Timur SeckinTransvaginal sonography for predicting the distance between rectosigmoid endometriosis and the anal verge
By Timur Seckin
For optimal surgery, pre-surgical assessment of the distance between rectosigmoid deep endometriosis lesions and the anal verge (Lesion to Anal Verge Distance-LAVD) is recommended by many specialists. A group of researchers from Norway, Austria, and Australia studied the accuracy of…
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Surgical approach to rectovaginal endometriosis.
By Selma Oransay
Recto-vaginal endometriosis incidence is estimated at 3.8%-37% among women with endometriosis and when it exists it's a part of deeply infiltrated endometriosis, thus advance stage endometriosis. Raimondo et al. from the Department of Obstetrics and Gynecology of the University of…
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Recurrence following surgery for subtypes of endometriosis
By Hale Goksever Celik
Endometriosis is a disease identified by the location of endometrial stromal and glandular cells outside the uterine cavity. It is considered as a gynecological disease of reproductive-aged women. Three subtypes of endometriosis are peritoneal endometriosis which defines the endometriotic lesions…
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Non-hormonal chemicals for endometriosis related pain reduction
By Nasuhi Engin Aydin
Loi and colleagues conducted a clinical prospective study at the Department of Obstetrics and Gynecology, University of Cagliari, Italy, and published in the journal "International Journal of Women’s Health". Formation of adhesions and/or interference with the reproductive process endometriosis, severe…
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Urgent Need For Building Resilience
By Timur Seckin
According to Naeem et al.’s article, “Coping with Covid”, Cognitive Behavioral Therapy (CBT) is the ideal intervention tool to increase resilience. Their study has recently been published in "Kyber Medical University Journal". The authors investigate the psychological impact of the Covid-19…
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Long-term Pregnancy Results after Surgical Removal of Endometrioma
By Irem Onur
Sun et al., from China, investigated the pregnancy outcomes and the related factors in patients with endometrioma and stage III-IV endometriosis along with a long-term follow-up postoperatively. Their study has recently been published in the journal named "Advances in Therapy".…
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Phytotherapy as an alternative endometriosis treatment
By Dr. Youngran Park
Endometriosis is an estrogen-dependent gynecological disease that affects 5–10% of women in fertile age. Different therapeutic strategies are available to treat this disease, such as surgery, hormonal therapies, and nonsteroidal anti-inflammatory drugs. Medical therapy usually consists of different hormonal drugs,…
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Adiposity, endometriosis type and severity
By Selma Oransay
Dr. Jiyoung from the division of Public Health, Department of Family and Preventive Medicine of the University of Utah, planned a prospective cross-sectional study to assess whether there is an inverse relationship between the adiposity and endometriosis. The results of…
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Preoperative serum CA 125 levels predict the severity of adhesions in endometriosis
By Irem Onur
Lee Y. et al., a group of researchers from Korea evaluated the correlation between preoperative serum markers and pelvic adhesions in endometriosis patients and explored the markers’ clinical value for outcome prediction. They have recently published their study in the…
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Treatment choices for abdominal wall endometriosis
By Selma Oransay
Welch et.al, from the Department of Radiology, Mayo Clinic, Rochester, worked with his gynecologist colleagues to underline the current treatment algorithm of abdominal wall endometriosis in Mayo Clinic. Their experience results recently published in the journal "Abdominal Radiology". Abdominal wall…
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Worrying signs of Endometriosis on Hysterosalpingography
By Murat Osman
Hysterosalpingography (HSG) is an imaging modality that utilizes fluoroscopy in order to evaluate the uterine cavity, fallopian tubes, and adjacent peritoneal cavity by injecting contrast media through the cervical canal. It is an important tool in the work-up of patients who…
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When to do - and when not to do surgery for endometriosis
By Dr. Youngran Park
Endometriosis is an estrogen-dependent disorder. It was estimated to affect about 176 million women in the world and usually causes pelvic pain and infertility. Unfortunately, the current understanding of this disease is very limited. Though there are many remaining questions,…
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Does the Severity of Endometriosis Increase the Risk of Complications Following Surgery?
By Özge Özkaya
The severity of endometriosis cannot predict the risk of complications after laparoscopy. Instead, the complexity of the surgical procedure itself may increase the risk of complications. This is according to a study published in the journal "Acta Obstetricia et Gynecologica Scandinavica".…
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Natural killer cells receptor expression in endometriosis
By Yu Yu
Increasingly, studies have reported that endometriosis pathogenesis is related to defect in immune functions. The data also points to the impaired function of natural killer (NK) cells, leading to less cytotoxic NK cell activity in endometriosis. Similar to B and…
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The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis
By Dr. Youngran Park
Endometriosis is a very common gynecological disorder affecting approximately 10% of reproductive-aged women, and it is known by the abnormal growth of endometrial stroma and glands outside the uterus. Though the pathogenesis of endometriosis is not clearly understood so far,…
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Risk of placenta previa is elevated in endometriotic women who underwent surgery.
By Selma Oransay
In the last decade concerns raised for surgical operations performed before pregnancies of endometriotic patients due to significantly increased risk of pregnancy complications such as placenta previa, preterm birth, hypertensive disorders of pregnancy, placental abruption, postpartum hemorrhage and small baby…
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Cloverleaf Sign: A new MRI sign for diagnosing DIE
By Selma Oransay
Magnetic resonance imaging provides accurate information for the staging of deeply infiltrating endometriosis, especially when the patient is virgin, obese or has limited transvaginal examinations due to pelvic pain. In this recently published study in Investive Radiology, Harma et al.…
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Recurrent endometriosis is a real challenge both for the patients and clinicians
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Current medical and surgical treatment options have several limitations including the side effects, costs, risk of recurrence, effects on conception capability. Recurrence is a…
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Endometriosis of the Appendix
By Timur Seckin
Endometriosis of the gastrointestinal tract is infrequent, and it rarely involves the appendix. A group of researchers from the United States of America reported a case of a 50-year-old postmenopausal woman with endometriosis in the vermiform appendix presenting as acute…
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Is there any difference between endometriosis patients with or without obliterated cul-de-sac during laparoscopic hysterectomy?
By Hale Goksever Celik
Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. It is diagnosed in 10% to 15% of reproductive-aged women. Women with endometriosis demand therapy for the most common symptoms, which are…
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A new technique for laparoscopic management of ovarian endometriosis.
By Selma Oransay
To cause a minimal hazardous effect on ovarian reserve during laparoscopic surgery of endometriomas is always a great concern for clinicians. Shaltout et al. from Cairo University, Egypt, examined the effect of "Surgicel" on preventing the recurrence of endometriomas and…
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Which surgical approach for bowel endometriosis?
By Irem Onur
A group of researchers from Spain, led by Dr. Alicia Hernández Gutiérrez, conducted a retrospective study to compare postoperative complications and recurrence of three surgical techniques: segmental bowel resection (group I), discoid excision (group II), and rectal nodule shaving (group…
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Endometriosis and the quality of life
By Selma Oransay
Recent developments of technics and improvement of skill in the laparoscopic field increased the courage of clinicians to attempt early and multiple diagnostic operations on endometriotic patients. Vanuccini et al. from NEUROFARBA, University of Florence, Florence, Italy recently published their…
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Adolescent dysmenorrhea and future endometriosis
By Selma Oransay
Dysmenorrhoea is typically classified as primary, or secondary due to underlying pathologies like fibroids, endometriosis, adenomyosis or uterine anomalies. Generally, long-term dysmenorrhea is present in endometriotic patient's anamnesis, but until recently, the research to clarify this connection remained retrospective. Knox et…
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How to predict complications for endometriosis surgery?
By Timur Seckin
In a new study co-led by scientists at Sorbonne University, a nomogram is built to better inform patients about the risk of deep endometriosis surgery without bowel involvement. The findings have been published in the European Journal of Obstetrics &…
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By Demet Candaş GreenImpact of hemostatic techniques used in endometrioma surgery on ovarian function
By Demet Candaş Green
This publication reports on an ongoing clinical trial that aims to assess whether the hemostatic techniques (methods to stop bleeding) used in ovarian endometrioma surgery have damaging effects on ovarian function. The clinical trial stemmed from a multitude of inconclusive…
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Disparities in Access to Healthcare in Women with Endometriosis
By Özge Özkaya
There are significant differences in the use of medical services and prescriptions between women with endometriosis who have private healthcare and those who don’t. This is according to a study published in the American Journal of Obstetrics and Gynaecology. This…
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Nanotechnology as a tool for targeted therapy of endometriosis
By Murat Osman
Endometriosis is a process whereby endometrial cells persistently grow and invade extra-uterine tissue through a primarily estrogen-dependent manner. These ectopic endometrial cells proliferate in sometimes an uncontrolled manner, similar to cancer or inflammatory tissues. To proliferate, cells need cholesterol to…
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Fusion US/MR imaging in the evaluation of deep infiltrating endometriosis
By Timur Seckin
Scioscia M. et al., from Italy presented a case of a large deep infiltrating nodule of the uterosacral ligament and discussed the importance of a relatively new technique, fusion US/MR imaging in their article. The article containing a video of…
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A position statement of diagnosing and treating endometriosis for gynecologists.
By Selma Oransay
Endometriosis Treatment Italian Group recently declared 10 "valuable" conducts to evaluate endometriotic patients and published them in Hum. Reprod. Open. This society consists of 16 university departments and training center with expert clinicians on endometriosis from Italy. After arising the idea of…
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A study about adnexial torsion doubts in patients with endometriosis.
By Selma Oransay
Endometrioma is the presence of endometriosis cysts in the ovary, and is one of the most common forms of endometriosis, with unknown pathophysiology. Adnexal torsion results in twisting ovarian tissues resulting in a decreased blood flow. The causes for adnexal torsion due…
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Surgical treatment of deeply infiltrating endometriosis in tertiary treatment centers
By Demet Candaş Green
In the present study, data from patients who were surgically treated for deep infiltrating endometriosis (DIE) in a tertiary referral unit, the Avicenna Centre for Endometriosis and Minimally Invasive Gynecology (ACEMIG, Tehran, Iran), were examined for rates of intraoperative and…
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The predictors for the coexistence of uterine leiomyomas and endometriosis
By Hale Goksever Celik
Uterine leiomyomas are the most common gynecological benign tumors affecting 20-25% of reproductive-aged women. Abnormal bleeding, pelvic pain, pelvic pressure, and infertility are major symptoms of these tumors. Endometriosis is another gynecological disease encountered in 10-15% of reproductive-aged women. The…
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The link between autoimmunity and endometriosis
By Yu Yu
A popular model to explain the etiology of endometriosis is Sampson’s theory of retrograde menstruation. In this model, the viable endometrial tissue is spread and attached to the peritoneal cavity through the fallopian tubes during menstruation, resulting in an inflammatory…
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Analogous pathways of peritoneal tumor wound healing and endometriosis.
By Selma Oransay
Endometriosis, diagnosed around 10-15% of women population in their reproductive period, is a chronically progressive inflammatory disease to cause peritoneal lesions while spreading into the abdominal cavity. The pathophysiology of the adhesions between the peritoneum and pelvic organs can be…
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The coelomic metaplasia hypothesis of endometriosis in MRKH cases
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity and its incidence is approximately 10% in the general female population. Although the pathophysiological mechanism is not clearly understood, the implantation theory by Sampson…
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By Serdar BalciPathophysiology of peritoneal endometriosis pain.
By Serdar Balci
This article is an invited editorial by Ferrero S et.al. from IRCCS Ospedale Policlinico San Martino, Genoa, Italy, published in the Annals of Translational Medicine. The authors describe the pathophysiology and underlying mechanisms of pain in peritoneal endometriosis with reference to the…
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Anti-angiogenic treatment for endometriosis
By Dr. Youngran Park
Endometriosis is a benign, estrogen-dependent gynecological disorder. The wide variety of surgical and medical treatment has been applied for treating endometriosis, but a definitive therapy has not been achieved so far. Thus, new therapeutic strategies need to be developed. Among…
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Menstrual blood-derived stem cells
By Selma Oransay
Chen et al. from the Center of Diagnosis and Treatment of İnfectious Disease, Zhejiang University, China penned this recent review in the Journal of Stem Cell Research Therapy which is presenting the clinical potential of MenSCs (Menstrual blood-derived stem cells). …
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Endometriosis and infertility: current concepts
By Nasuhi Engin Aydin
Hungarian and US scientists have published a comprehensive review on infertility related to endometriosis in Frontiers in Endocrinology, November 2018 issue. Endometriosis is a common entity in women of reproductive age which often leads to infertility. Compiled research data reveal…
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Gal-3 can be a pharmacological target in endometriosis treatment
By Demet Candaş Green
Galectins are known to play a significant role in angiogenesis, which is a key event contributing to the development of many disease conditions, one of which is endometriosis. Past studies, upon examining several human endometriotic lesions, showed that Galectin-3 (Gal-3)…
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Long non‐coding RNA, Epithelial mesenchymal transition, and Endometriosis
By Dr. Youngran Park
Endometriosis is an estrogen‐dependent inflammatory gynecologic disease and requires attention. However, an in‐depth understanding of the latent pathogenesis of endometriosis development and its new innovative therapeutics are urgently needed. Epithelial‐mesenchymal transition (EMT) refers to the special biological process of epithelial…
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Building an ultrasonographic database for superficial endometriosis.
By Selma Oransay
Chowdary et al. from University of Auckland, Australia, recently published a retrospective, small group study in Australian New Zeland Journal of Obstetrics and Gynecology, to demonstrate ultrasonographic findings of mild endometriosis patients with pelvic pain are associated with their laparoscopic diagnosis.…
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Endometriosis and female pelvic pain in all aspects
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence of the disease ranges between 6-10% in reproductive-aged women. However, endometriosis is more frequently encountered in women with chronic pelvic pain and…
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The role of circulating microRNA's in Endometriosis
By Dr. Youngran Park
Endometriosis is an estrogen-dependent disorder. This disease affects approximately 10% of reproductive-aged women and 20% to 50% of infertile women. Steroidogenic factor 1 (SF-1) is an essential transcriptional regulator coordinately regulating multiple genes involved in estrogen biosynthesis. SF-1 is known…
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What clinicians know about adenomyosis? Any association with severe endometriosis?
By Selma Oransay
Dior et al. from the Royal Women's Hospital in Parkville, Australia, designed a prospective study to assess the association between severity of endometriosis and sonographic evidence of adenomyosis (SEOA) in their recently published article appearing in The Journal of Minimally…
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A Brief Review of Endometriosis
By Timur Seckin
Endometriosis is a common disease among women of reproductive age. It is more frequently seen among women without prior pregnancies, women with a family history of endometriosis, and women with abnormal menstrual periods. Peiris et al., researchers from the United…
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Laparoscopic mesenteric vascular and nerve sparing surgery as a tool for DIE resection
By Murat Osman
Endometriosis can be characterized by a wide range of clinical aggressiveness based upon the location, character, and growth of ectopic endometrial implants. As one of the most aggressive forms of endometriosis, deep infiltrating endometriosis (DIE) is known to involve the…
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Progesterone Receptor Status in Endometriosis
By Serdar Balci
Some patients do not respond to progesterone hormone therapy. In this study recently published in the Journal of Clinical Endocrinology and Metabolism, the authors led by Hugh S. Taylor from the Department of Obstetrics, Gynecology and Reproductive Sciences from Yale…
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The diagnosis and management of endometriosis in Korea
By Selma Oransay
The Korean Society of Endometriosis has scrutinized the present published literature of endometriosis in the domestic and international platform to provide new guidelines and the clinical management of the disease. The study was recently published in the journal "Obstetrics and Gynecology…
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Can MRI be used to detect anterior pelvic endometriotic lesions?
By Hale Goksever Celik
Deep infiltrating endometriosis is the most severe manifestation of endometriosis. It is defined as the infiltration of ectopic endometrial tissue under the peritoneum, pelvic structures, and the organ walls such as the uterosacral ligaments, colon, vagina, bladder, ureter, rectovaginal septum,…
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Three dimensional sono-vaginography to diagnose rectovaginal endometriosis
By Hale Goksever Celik
Deep infiltrating endometriosis is defined as the localization of ectopic endometrial tissue penetrating more than 5 mm into the affected pelvic organs. Rectovaginal endometriosis is the most severe form of deep infiltrating endometriosis in which ectopic endometrial tissue infiltrating rectum…
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PROPOFOL: a new combat for endometriosis?
By Selma Oransay
Feng et al, from the Department of Gynecology Weifang Medical University Hospital, Shandong, China, recently published their prospective experimental research in the journal Experimental and Therapeutic Medicine. Propofol, a rapid and short-term anesthetic substance, recently has been shown to prevent cancer through inhibiting…
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Parametrial endometriosis: A harder form of endometriosis
By Hale Goksever Celik
Deep infiltrating endometriosis is the most severe manifestation of endometriosis, affecting 20% of all patients with endometriosis. It is defined as the infiltration of ectopic endometrial tissue under the peritoneum, pelvic structures, and the organ walls such as the uterosacral…
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Laparoscopic surgery of endometriosis through three compartments
By Selma Oransay
This case study which is published in the J. of Minimally İnvasive Gynecology is the video demonstration of Collin et al who performed the laparoscopic operation of their patient in Gynecologic Surgery Department of Strasburg Hospital University, France. 37 years old…
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Multimodality imaging and clinicopathologic assessment of abdominal wall endometriosis
By Irem Onur
Abdominal wall endometriosis is a rare clinical entity frequently diagnosed with a significant delay and easily misinterpreted despite multimodality imaging. In the study of Jaramillo-Cardoso et al. which has recently been published in the journal Abdominal Radiology, the clinical, multimodality…
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A rare location of endometriosis: Perineum
By Timur Seckin
A rare case of perineal endometriosis is reported by Dr. Ravikant, from India, and has been recently published in the "Journal of Medical Ultrasound". The patient, a 28-year-old woman with one living child, presented with a 6-month history of a…
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Fighting with endometriosis
By Irem Onur
Maduro M.R. reviewed three separate studies on potential new targets to successfully manage endometriosis in her recent paper titled “Novel Strategies to Fight Endometriosis” published in the journal Reproductive Sciences. In the autotransplantation rat model of Torres-Reveron et al., the…
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Endometriosis Surgery Reduces Pain and Improves Quality of Life
By Özge Özkaya
Endometriosis surgery improves pelvic and sexual pain according to a study published in the Journal of Minimally Invasive Gynecology. This improvement stays stable over time meaning that the benefits of surgery last for years. In order to assess the effect…
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Cosmetics and some household products could be responsible for worsening endometriosis.
By Selma Oransay
A controlled clinical study recently published in the Journal of Human Reproductive Sciences, composed by Nazir et al. from the University of Health Sciences, Lahore, Pakistan. The study compared the blood diethyl hexyl phthalate (DEHP) levels of fifty infertile women laparoscopically diagnosed…
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Transvaginal ultrasound for "rectosigmoid endometriosis" diagnosis: Is bowel preparation necessary?
By Hale Goksever Celik
Rectosigmoid endometriosis is a severe form of deep endometriosis. Women having rectosigmoid endometriosis present with pain and several intestinal complains such as constipation, diarrhea, intestinal cramping, abdominal bloating, feeling of incomplete evacuation, the passage of mucus and rectal bleeding during…
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Reduced pain and increased fertiliy rates after surgery for colorectal endometriosis
By Selma Oransay
This prospective cohort study which recently published in AOGS by Hudelist et al. from Oslo University, Norway is about their one hundred thirty-four laparoscopic operations of DIE cases performed between 2011 and 2016, in a tertiary center in Oslo. The…
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How to evaluate ureteral endometriosis : A review of the literature
By Selma Oransay
In this recently published review of the literature, Barra et al. from Genova, Italy intend to provide a useful tool to guide physicians in the management of deep infiltrating endometriosis. Authors elected 67 abstracts from Pubmed and Medline in accordance with PRISMA…
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How are endometriosis patients managed clinically?
By Irem Onur
This review paper by Falcone and Flyckt, entitled “Clinical Management of Endometriosis” published in the journal Obstetrics & Gynecology aims to summarize the current strategies for treating endometriosis patients with pain, pelvic dysfunction, and subfertility related to their disease. There are many…
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Women recommended laparoscopy for chronic pelvic pain
By Irem Onur
Chronic pelvic pain is a diagnostic and therapeutic dilemma. It has many etiologies in many organ systems. Clinician and patient factors affect the management of chronic pelvic pain. Mirowska-Allen K.L. et al. have recently published an article titled, “The characteristics of…
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Vitamin C supplementation in the patients with endometriosis undergoing in vitro fertilization-embryo transfer
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Women having endometriosis present with dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Thus, infertility remains a significant problem for women with endometriosis. Endometriosis is…
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By Deniz KocasQuestionnaire based evaluation of sexual life after laparoscopic surgery for endometriosis
By Deniz Kocas
Researchers from Denmark note that laparoscopic surgery is being increasingly used for the treatment of endometriosis due to its safety and effectiveness. However, treatment success is often evaluated through follow-up on the experience of pain, leaving other important aspects of…
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Complementary treatments for endometriosis symptoms: acupuncture, exercise, electrotherapy, or yoga?
By Yu Yu
Endometriosis is associated with debilitating symptoms in some women including dysmenorrhea, chronic pelvic pain, deep dyspareunia, dyschezia, and dysuria. There are a few therapeutic options to treat these symptoms; however, only a few studies have considered treating the pain symptoms…
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Comparing opioid and nonopioid therapy for chronic pain
By Deniz Kocas
Over the last few decades, North-America and Europe show continued increase in prescription rates of opioids. Evidence shows significant pain reduction with opioids in the short term compared to placebo, however whether opioids are superior to non-opioids even in the…
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Is there a new hope for the prevention of endometriotic invasions?
By Selma Oransay
This research which recently published in Biomed Research International is performed by Xiaomei et al. from Obst/Gyn, Pathology and Genetic departments of three hospitals in Changsha, CHINA. The authors planned a prospective and controlled biochemical study to specify the role…
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Fluorescence Guided Surgery: a New Technique to Treat Deep Infiltrating Endometriosis
By Özge Özkaya
Fluorescence-guided surgery could help differentiate recto-vaginal deep infiltrating endometriosis nodules (RVDIEN) from healthy rectal tissue and remove them successfully without perforating the rectum, according to a study published in the scientific journal Surgical Innovation. The method could offer a better,…
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Can we predict the complexity of laparoscopic surgery by ultrasound?
By Selma Oransay
This is a multicentric, retrospective cohort study recently published in the Journal of Minimally Invasive Gynecology by Tompsett et al. in which the results of the transvaginal ultrasonographic examinations (TVS) are compared to the results of the laparoscopic operations performed…
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Endometriosis Development: Pathogenesis and genomics
By Selma Oransay
In this review recently published in the International Journal of Molecular Sciences, Baranow et al from Saint Petersburg, Russia, hypothesize the existence of an endometriosis development genetic program (EMDP) that governs the origin of endometrium stem cells programmed for endometriosis; their transition…
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An Alternative Medical Approach to Treat Endometriosis?
By Özge Özkaya
Molecules that act on a protein called SRC-1 could constitute a new medical tool to treat endometriosis, according to a study published in the Journal of Endocrinology. SRC-1 makes certain parts of DNA more accessible therefore increasing gene expression or…
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Is there a definitive guideline for the surgical management of endometriosis?
By Murat Osman
Endometriosis is a chronic inflammatory disease that is defined by the presence of ectopic endometrial tissue outside of the uterus. Unfortunately, endometriosis continues to be a leading cause of chronic pelvic pain in women of reproductive age. This article titled,…
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Predictors of psychological distress
By Deniz Kocas
Studies have now established that endometriosis can negatively impact mental health and quality of life, however, some studies show that not all women with endometriosis are necessarily more distressed than healthy women. This suggests that individual differences may explain women’s’…
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What is being done to help surgeons detect endometriosis during laparoscopy
By Murat Osman
The gold standard for the diagnosis of endometriosis is diagnostic laparoscopy and histologic confirmation. During laparoscopy, visualization of as many lesions as possible may hold better long-term clinical outcomes. Peritoneal endometriosis is difficult to diagnose intraoperatively due to the heterogeneity…
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New Target for Endometriosis Treatment?
By Özge Özkaya
NR4A1 could be a novel target for the treatment of endometriosis, according to a study published in the scientific journal Cell Physiology and Biochemistry. NR4A1 is a receptor protein involved in cell division, inflammation, and programmed cell death. The development…
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Could Gabapentin Make my Pain Go Away?
By Özge Özkaya
Gabapentin could effectively reduce endometriosis-associated pain, according to a new study published in the Journal of Pain Research. The study that was conducted in mice and endometriotic tissues from patients suggests that certain proteins present on the surface of cells…
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Patient-centered endometriosis care
By Hale Goksever Celik
Endometriosis is defined as endometrial glands and stroma that exist outside the uterine cavity. Ectopic endometrial tissue and resultant inflammation can cause dysmenorrhea, dyspareunia, chronic pain, and infertility, all of which reduce the quality of life. The aim of the…
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By Kasthuri NairDifficulties Associated with Diagnosing Ascites and Encapsulating Peritonitis in Endometriosis
By Kasthuri Nair
De Magalhães et al. recently published a paper titled “Ascites and Encapsulating Peritonitis in Endometriosis: a Systematic Review with a Case Report” in Revista Brasileira de Ginecologia e Obstetrícia. The team from the Universidade Federal do Ceará and the Universidade…
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Will my Endometriosis Respond to Hormone Therapy?
By Özge Özkaya
Every woman has a different set of hormone receptors in the lining of their uterus. Yet, hormone-based therapies that are used to treat women with endometriosis do not take into consideration these differences among patients. Analyzing, which particular hormone receptors…
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A clearer picture of "endometriosis after menopause"
By Irem Onur
Delfin Avendano Tan and Marie Josephine Guanlao Almeria are obstetrician-gynecologists from the Philippines. They recently published a review article titled "Postmenopausal endometriosis: drawing a clearer picture". In this paper, the authors discussed the pathogenesis, risk factors, and management of postmenopausal…
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Psychosocial impact of endometriosis
By Deniz Kocas
In this review article, researchers from Switzerland report a review to outline the consequences of endometriosis on the psychological, sexual, and interpersonal functioning of both patients and their partners, in the journal Best Practice & Research Clinical Obstetrics and Gynecology.…
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Stenoses in the colorectal anastomose sites after DIE surgery
By Hale Goksever Celik
Deep infiltrating endometriosis (DIE) is a particular form of endometriosis that penetrates at least 5 mm under the peritoneal surface. DIE is primarily located in the rectosigmoid junction and the rectum with an incidence of 70% and 90%, respectively. The…
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A Way to Better Diagnose Colorectal Endometriosis
By Özge Özkaya
Combining magnetic resonance imaging (MRI) with computed tomography-based virtual colonoscopy (CTC) can make the assessment of colorectal endometriosis more accurate. This is important because it can help doctors plan the surgery better and inform their patients. In order to evaluate…
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Emerging medical treatments for endometriosis
By Murat Osman
Endometriosis is a disease whereby uterine tissue grows outside the walls of the uterus to the surfaces of other tissues in the body. It is a chronic disease and relies upon estrogen to grow and survive. Current medical therapies take…
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Is the Endometriosis Fertility Index Reliable?
By Kasthuri Nair
Zhang et al. recently published a paper titled “Prediction of Endometriosis Fertility Index in patients with endometriosis-associated infertility after laparoscopic treatment” in Reproductive BioMedicine Online. The research group from the West China Second University Hospital in Sichuan University wanted to…
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S100A6 May be a Promising Target for Endometriosis Treatments
By Kasthuri Nair
Peng et al., a group primarily from the Zhejiang University Medical College, recently published a paper in Gynecological Endocrinology titled “Upregulation of S100A6 in patients with endometriosis and its role in ectopic endometrial stromal cells.” This paper delineates a study…
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Stem cell therapy for the premature ovarian failure
By Dr. Youngran Park
Premature ovarian failure (POF) is one of the common disorders found in women. The cause of POF is not fully known, but various factors have been suggested. In genetically, X and autosomes chromosome abnormalities could result in some POF. The…
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Highlights Thoracic Endometriosis Case
By Kasthuri Nair
Dr. Tamer Seckin, MD, the co-founder of the Endometriosis Foundation of America, was recently featured in a New York Times article titled “The Woman Was Fit and Healthy. Why Did Her Lung Mysteriously Collapse?” The article describes a rather unusual…
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Picture This: 8K UHD Television System for Endometriosis Surgery
By Kasthuri Nair
This case report by Aoki et al. was published in the journal "Videosurgery and Other Miniinvasive Techniques" under the title “Effect of an 8K ultra-high-definition television system in a case of laparoscopic gynecologic surgery.” In this publication, the authors delineated…
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Mechanism for Migration of Endometriosis Cells in the Body
By Kasthuri Nair
Li et al. recently published a paper in Stem Cells titled “Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis.” This article seeks to understand the mechanisms underlying the migration of endometriosis. The authors initially hypothesize that endometriosis-derived mesenchymal stem cells…
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A How-To Guide for Endometriosis Surgery
By Kasthuri Nair
The European Society for Gynaecological Endoscopy (ESGE), ESHRE, and the World Endometriosis Society (WES) recently published a document titled “Recommendations for the surgical treatment of endometriosis—part 1: ovarian endometriomas.” This publication provides surgeons with recommendations for the technical aspects of…
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The Past, Present, and Future of Diagnosing Endometriosis
By Kasthuri Nair
This review titled “Endometriosis: Epidemiology, Diagnosis and Clinical Management” published in Current Obstetrics and Gynecology Reports examines the distribution and factors associated with endometriosis. The analysis by Parasar, Ozcan, and Terry also delineates potential biomarkers and risk factors that could…
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Benign Gynecological Tumors in Women with Endometriosis
By Kasthuri Nair
Matalliotaki et al. recently published a paper titled “Coexistence of benign gynecological tumors with endometriosis in a group of 1,000 women” in Oncology Letters. The study had two main objectives. The first goal was to understand the link between endometriosis…
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"N-myc Downstream-Regulated Gene 1" and Endometriosis.
By Dr. Youngran Park
NDRG1 is implicated in many different cellular functions such as differentiation, proliferation, migration, invasion, and vascularization. In endometriosis, NDRG1 is identified as an inhibitor of several important pathways. To focus on the potential function of NDRG1 in endometriosis, Lou et…
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Long-term Use of Dienogest can Prevent Recurrence of Endometriomas
By Kasthuri Nair
Chandra et al. recently published a paper titled “Clinical experience of the long-term use of dienogest after surgery for ovarian endometriomas” in Obstetrics and Gynecology Science. The publication explored the benefits and repercussions associated with long-term use of dienogest, a…
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Reason Why Hormone Therapy Alone Cannot Cure Endometriosis Uncovered
By Özge Özkaya
Researchers in Belgium have shed light on why hormone therapy cannot cure endometriosis on its own in a study published in the scientific journal Gynecological Endocrinology. Their findings could shape the direction of future research and may help to find…
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When Endometriosis Becomes Malignant
By Kasthuri Nair
Anglesio and Yong recently wrote a review titled “Endometriosis-associated Ovarian Cancers” that was published in Clinical Obstetrics and Gynecology. This review explored the relationship between endometriosis and ovarian cancers. It is important to note that this review is a compilation of…
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Intestinal Endometriosis and Colorectal Cancer versus T4 Colorectal Cancer
By Kasthuri Nair
Ishii et al. recently published a paper titled “Intestinal endometriosis combined with colorectal cancer: a case series” in the Journal of Medical Case Reports. This case report follows 7 Japanese women who have intestinal endometriosis and colorectal cancer. These women…
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Diagnostic and treatment guidelines for gastrointestinal and genitourinary endometriosis.
By Murat Osman
Endometriosis may affect the pelvic reproductive system, but it can also be found in non-reproductive organs such as the gastrointestinal and urinary tract. The article outlined below discusses the diagnosis and management of genitourinary and gastrointestinal endometriosis. Gastrointestinal endometriosis: The…
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Atypical Sites of Deeply Infiltrative Endometriosis
By Yu Yu
Endometriosis is the presence of endometrial tissue outside the uterine cavity and is characterizes by fibrosis and inflammatory reaction. The pelvic cavity is the most common location for endometriotic lesions, which involves the retro-cervical space, ovaries, vagina, rectosigmoid colon, bladder…
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How to Minimize the Costs Associated with Endometriosis Care
By Kasthuri Nair
Paolo Vercellini, Maria Pina Frattaruolo and Laura Buggio, from Milan, Italy, recently published an editorial titled “Toward minimally disruptive management of symptomatic endometriosis: reducing low-value care and the burden of treatment” in Expert Review of Pharmacoeconomics & Outcomes Research. The…
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Laparoscopic Bowel Resection Can Be Beneficial Rectosigmoid Endometriosis
By Kasthuri Nair
Riiskjær et al. recently published a paper titled “Pelvic Pain and Quality of Life Before and After Laparoscopic Bowel Resection for Rectosigmoid Endometriosis: A Prospective, Observational Study” in Diseases of the Colon & Rectum. This paper focuses on the effects…
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Should Women with Endometriosis have IVF Treatment to Conceive Following Laparoscopic Surgery?
By Özge Özkaya
Women affected by endometriosis-associated infertility who are younger than 35, and have a good ovarian reserve and a partner with normal semen parameters can benefit from a so-called integrated approach for the management of their infertility, according to a study published…
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MRI Best at Detecting Intestinal Deep Infiltrating Endometriosis
By Özge Özkaya
Magnetic resonance imaging (MRI) seems to be a better method in identifying deep infiltrating endometriosis in the intestine compared to two-dimensional ultrasonography (2DUS), found a study by researchers in Italy and Spain. However, this does not seem to be the…
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By Laura ArdighieriEffects of osteopathic manipulative therapy in patients with colorectal endometriosis
By Laura Ardighieri
Alternative treatments have been used for colorectal endometriosis, between them Chinese medicine, acupuncture and more recently osteopathic manipulative therapy. The osteopathic manipulative therapy has been shown to reduce the chronic pain working on muscular contractions due to vicious analgesic positions.…
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EFA Medical Conference 2017: "Hormone and Cytokine Sensitivity in Endometriosis" Presentation by Dr. Robert Taylor
By Kasthuri Nair
The first presenter of the “Estrogen from Inflammation to Cancer: A Distant Link?” section of EFA 2017 Medical Conference was Dr. Robert Taylor from Wake Forest University Health Sciences. Dr. Taylor’s presentation was titled “Hormone and Cytokine Sensitivity in Endometriosis.”…
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EFA Medical Conference 2017: "Breast Cancer in Young Women; Early Diagnosis Timely Intervention" Presentation by Dr. Stephanie Bernik
By Kasthuri Nair
Dr. Stephanie Bernik is the Chief of Surgical Oncology of Surgery and General Surgery at the Lenox Hill Hospital. She recently presented at the EFA 2017 Medical Conference, and her presentation was titled “Breast Cancer in Young Women; Early Diagnosis…
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Treatment of minimal endometriosis in infertile women
By Demet Candaş Green
For women with mild/minimal endometriosis, European Society of Human Reproduction and Embryology (ESHRE) recommends the removal of endometriotic lesions to improve fertility and increase pregnancy rates. For women undergoing assisted reproductive treatment, there is ongoing debate whether surgical removal of…
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EFA Medical Conference 2017: "Endometriosis: hormonal or surgical? My reality!" Presentation by Dr. Harry Reich
By Kasthuri Nair
Dr. Harry Reich, the Former Director of Advanced Laparoscopic Surgery at Columbia University Department of OBGYN, was the last speaker in the Mission and History part of the EFA 2017 Medical Conference. His presentation was titled “Endometriosis: hormonal or surgical?…
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EFA Medical Conference 2017: "Cells Are the New Cure" Presentation by Dr. Max Gomez
By Kasthuri Nair
Dr. Max Gomez is an award-winning broadcast journalist, CBS News Medical Correspondent, and a presenter at the EFA 2017 Medical Conference. Dr. Gomez’s presentation was titled “Cells Are the New Cure: The Cutting-Edge Medical Breakthroughs That Are Transforming Our Health.”…
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A Combination Treatment of Psychotherapy With Somatosensory Stimulation for Pain Reduction
By Kasthuri Nair
Women suffering from endometriosis often cite pelvic pain, anxiety, and depression as some of the worst core symptoms experienced due to the disease; however, emerging research has shown these signs, specifically pelvic pain, may be influenced by psychological trauma. In…
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Adhesion molecules and endometriosis
By Yu Yu
Decoy receptor 3 (DcR3) is an immunomodulator regulated by estrogen and can regulate cell adhesion, which is a critical step in the initiation of endometriosis. In particular, the cell adhesion molecules, including ICAM-1 (intercellular adhesion molecule 1) and HCAM (homing…
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The Endometriosis Fertility index Could Help Better Predict the Chance of Conceiving After Laparoscopy
By Özge Özkaya
The endometriosis fertility index (EFI) can more reliably predict the chance of a woman getting pregnant following endometriosis surgery compared to the revised-American Society of Reproductive Medicine score, according to a study published in the scientific journal Gynecologic and Obstetric…
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Characteristics and location of extrapelvic endometriosis
By Demet Candaş Green
The authors of this study reviewed the medical records of 1000 women with endometriosis from two geographical areas, New Haven, US and Crete, Greece over a 20-year period with a goal of identifying the presence and location of extrapelvic endometriosis…
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Cohort study on outcomes of laparoscopic endometriosis surgery
By Yu Yu
Laparoscopic surgery followed by histological confirmation is considered a standard for diagnosis, staging, and treatment of endometriosis. Radical and conservative surgical approaches are often required for the removal of endometriotic lesions in the case of vaginal or rectal wall deep…
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Updates in the Field of Endometriosis: Surgery
By Kasthuri Nair
Surgery is one of the treatment options offered for individuals with endometriosis. With that in mind, there are a variety of surgical procedures that can be offered to an individual with endometriosis. In the chapter titled “Surgery and Endometriosis,” Zanelotti…
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By Vishaan NurseyArcyriaflavin A Decreases Endometriosis Cell Viability and Proliferation
By Vishaan Nursey
The purpose of this research topic was to determine whether Arcyriaflavin A could serve as a potential new therapeutic option for those suffering from Endometriosis. Arcyriaflavin A is a Cyclin D1 inhibitor. Cyclin D1 regulates the cell cycle by interacting…
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Cystectomy More Likely to Cause Infertility than Laparoscopic Vaporization
By Özge Özkaya
Treating patients with endometriotic ovarian cysts using laparoscopic vaporization may be better than treating them with cystectomy, or the surgical removal of cysts, regarding fertility. This information is according to a study conducted by Japanese scientists and published in the Asian…
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The Potential Molecular Mechanisms that Drive Endometriosis Progression
By Kasthuri Nair
Endometriosis is a mysterious disease in that the exact mechanism that causes the illness is still at large. Yang et al. recently published a paper in the European Review for Medical and Pharmacological Sciences that hopes to elucidate the molecular…
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Women with Deep Infiltrating Endometriosis Have a Higher Risk of Appendix Involvement
By Özge Özkaya
Women with deep-infiltrating endometriosis, a form of endometriosis that invades the abdominal and pelvic cavity, have an increased risk of developing endometriosis of the appendix. It is therefore important to check women with deep infiltrating endometriosis for appendix involvement during…
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An Antagonist for Endometriosis Disease Progression: LINC00261
By Kasthuri Nair
The molecular mechanisms surrounding endometriosis remain elusive to this day. Sha et al. from Wenzhou Medical University, China, reported that LINC00261, a long non-coding RNA, may play a substantial role in inhibiting the pathogenesis of this painful illness. Their paper…
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Combo Therapy of Micronized palmitoylethanolamide/trans-polydatin for Endometriosis Pain
By Kasthuri Nair
Endometriosis is a painful illness and many researchers in the field work to offer women with the disease some form of respite from the suffering. Indraccolo, Indraccolo, and Mignini are three such researchers and they recently published a paper titled…
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By Elisabetta KuhnReevaluating response and failure of medical treatment of endometriosis
By Elisabetta Kuhn
Endometriosis is a chronic disease affecting more than 10% of women in the fertile age and causing "pain" symptoms, that may require medical therapy. Most medical treatments used for endometriosis exert a hormonal mechanism to curtail estrogen effects either locally…
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Ping-Chong-Jiang-Ni Formula: A Natural Treatment
By Kasthuri Nair
In the world of modern medicine, natural and herbal remedies are often under utilized. Liang et al. recently published an article in Evidence-Based Complementary and Alternative Medicine where they explored the benefits of using a Chinese Herbal Medicine to treat…
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Abdominal Wall Endometriosis
By Kasthuri Nair
Endometriosis can present itself in many places including within the pelvic organs, the more common manifestation, and outside of the pelvic organs, often referred to as extrapelvic endometriosis. One form of extrapelvic endometriosis is Abdominal Wall Endometriosis (AWE). Yela, Trigo,…
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Detection of Uterine Malformations and its Link to Endometriosis
By Kasthuri Nair
Dr. Abd El Fattah recently published a research article titled “Uterine Cavity Abnormalities in Patients with Endometriosis in Alexandria: A Diagnostic Test Accuracy Study” in Obstetrics and Gynecology International that delineated and presented the results of his study. The study has two…
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Endometriosis and Productivity at Home and in the Workplace
By Kasthuri Nair
Soliman et al. recently published an original paper in the Journal of Managed Care and Specialty Pharmacy that discusses the impact that endometriosis symptoms have on an individual’s productivity level at home and work. This publication is titled “The Effect…
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The Benefits of Primary Surgery
By Kasthuri Nair
Ahmad, Hussin, and Ahmad recently conducted a cohort study, and they published the results within an article titled “An evaluation of the quality of life in women with endometriosis who underwent primary surgery: a 6-month follow-up in Sabah Women &…
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Naturally Occurring Plant Product May Hold Promise for the Treatment of Endometriosis
By Özge Özkaya
A natural plant product called apigenin might be a potential new treatment for endometriosis according to a study published in the Journal of Cell Physiology. “ […] Apigenin is a potential novel therapeutic agent to overcome current limitations in the…
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ICSI Outcomes for Laparoscopic Intervention of Endometriosis
By Kasthuri Nair
Women with endometriosis can have trouble conceiving and often turn to fertility treatments for help. Guler et al. recently published a paper in Systems Biology in Reproductive Medicine titled “The Impact of laparoscopic surgery of peritoneal endometriosis and endometrioma on…
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Novel Biological Pathway Could Offer new Treatment Option for Endometriosis
By Özge Özkaya
Researchers have identified a novel biological pathway that may be involved in endometriosis. Targeting this pathway may, therefore, be a new alternative approach to treating the condition in the future. Endometriosis is characterized by the tissue that normally lines the…
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Robotic Assisted Laparoscopy Not Better Than Standard Laparoscopy
By Özge Özkaya
Robotic-assisted laparoscopy (RAL) does not seem to offer any benefits over standard laparoscopy, according to a study published in the scientific journal Reproductive Biomedicine Online. According to the authors of the study more research is needed to investigate the role…
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By Ezio RosatoWomen with Endometriosis Undergoing Surgery Often Require Further Treatment
By Ezio Rosato
Recurrence of endometriosis is common even in women who underwent surgery, a new study confirmed. This suggests that women with endometriosis should be closely followed up even after treatment with surgery. For the study published online in the Journal of…
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Does laparoscopic excision or laparoscopic ablation offer the best long-term pain relief from endometriosis?
By Murat Osman
This systematic and meta-analysis of several studies aimed to compile data regarding the reduction of dysmenorrhea (menstrual pain), dyschezia (difficult defecation), dyspareunia (painful sexual intercourse), chronic pelvic pain and Endometriosis Health Profile (EHP-30) score 2-12 months after treatment. Visual analog scale (VAS)…
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Laparoscopic Hysterectomy as Effective as Total Abdominal Hysterectomy, Study Suggests
By Ezio Rosato
Laparoscopic hysterectomy, a minimally invasive surgical procedure that is used to remove the uterus, results in similar rates of disease-free survival among women with stage 1 endometrial cancer as the standard abdominal hysterectomy, showed a study published in The Journal…
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