Adhesion molecules and endometriosis


Adhesion molecules and endometriosis

DcR3 promotes cell adhesion and endometriosis

Key Points

Highlight:

  • Decoy receptor 3 (DcR3) is critical in endometriosis development.

Importance:

  • Inhibition of DcR3 may be a promising treatment for endometriosis.

What's done here:

  • Histochemical staining to investigate DcR3 expression in 70 endometriosis patients and 31 healthy individuals.
  • Comparison of clinical endometriosis parameters between DcR3-positive and DcR3-negative patients.
  • Human endometrium inoculation into wild-type and DcR3-transgenic mice to observe processes of endometrial cells’ adhesion and migration.

Data:

  • Human ectopic endometrial cells showed DcR3 upregulation.
  • DcR3 level positively correlated with adhesion molecules ICAM-1 (intercellular adhesion molecule 1) and HCAM (homing cell adhesion molecule, CD44).
  • DcR3 expression associated with endometriosis severity.
  • In animal studies, DcR3 promoted the growth and spreading of the endometrium.

Limitations:

  • Although DcR3 appeared to correlate with severity, it was detected in 69% (48 out of 70 patients) suggesting that it may not account for all endometriosis cases.
  • Increase sample size may increase the generalisability of the study.
  • The presence and function of DcR3 in normal tissues physiologically and other pathological tissues should be evaluated and compared.

Lay Summary

Decoy receptor 3 (DcR3) is an immunomodulator regulated by estrogen and can regulate cell adhesion, which is a critical step in the initiation of endometriosis. In particular, the cell adhesion molecules, including ICAM-1 (intercellular adhesion molecule 1) and HCAM (homing cell adhesion molecule, CD44) are associated with aberrant adhesion in endometriosis. The DcR3 expression is upregulated by sex hormones and its level in the serum become detectable during the menstrual cycle, while undetectable in normal tissues. This study by Tsai et al. in the Journal of Pathology examined if DcR3 plays a critical role in the pathogenesis of endometriosis.

The authors found that DcR3 was upregulated in the ectopic endometrium, and its expression positively correlated with the expression levels of adhesion molecules HCAM and ICAM-1. DcR3 also appeared to have critical clinical associations, in which patients’ endometriosis severity scores and adhesion scores were even positively correlated with DcR3 expression. Using a multivariate regression model, DcR3 served as a promising indicator to predict endometriosis severity.

Additional experiments in animal model suggested parallel findings in which transgenic DcR3 mice showed increased growth of ectopic endometrium than wildtype counterparts. More endometriosis lesions were noted in DcR3-transgenic mice, and the endometriosis progression can be abrogated by knocking down DcR3 using shRNA.

It must be noted that DcR3 expression was not observed in all endometriosis tissues, with around 69% tissues being DcR3 positive. The DcR3 positivity does associate with endometriosis severity. All these results support the idea that DcR3 can promote ectopic epithelial cell adhesion and enhance endometriosis progression. Hence, the use of DcR3 targeting therapy may be useful for patients with positive DcR3 status. Additionally, DcR3 may be a promising biomarker as it is also associated adhesion scores, pelvic pain scores, and dysmenorrhea in patients.


Research Source: https://www.ncbi.nlm.nih.gov/pubmed/29057478


biomarker therapeutic target decay receptor immunomodulator cell adhesion

DISCLAIMER

Endonews is designed to strictly highlight the most recently published scientific research that focuses on endometriosis. It is not designed to provide medical advice or an opinion on the best form of treatment. We highly stress the importance of not using this site as a substitute for seeking an experienced physician, which is highly recommended if you have any questions or concerns regarding your endometriosis needs. We believe in the consciousness of our reader to discriminate that research is different than "standard of care," and trust that they can keep in mind that here at Endonews, we summarize the newest peer-reviewed scientific medical literature, without bias.