By Özge ÖzkayaLong-term Dienogest Treatment and the Chance of Conceiving With IVF
By Özge Özkaya
It is not clear whether long-term treatment with dienogest before in vitro fertilization (IVF) affects pregnancy and live birth rates in women with endometriosis, according to a new study published in the Journal of Obstetrics and Gynaecology Canada. “Given limited…
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Does The Severity of Endometriosis Pain Affect the Chance of Having a Baby With IVF?
By Özge Özkaya
Severe pain symptoms in endometriosis have no relation with the outcomes of assisted reproductive techniques such as in vitro fertilization (IVF), according to a new study published in the journal Human Reproduction. This finding suggests that the decision-making process for…
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By Eylül GÜNQuercetin and its effects on endometriosis
By Eylül GÜN
Endometriosis, as a disease characterized by chronic inflammation and fibrosis, could be a potential target for quercetin, a flavonoid found in various foods and botanicals, and a known senolytic agent with many effects including antioxidant, anti-inflammatory, and immune-modulatory properties. Studies…
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By Selma OransayEarly diagnosis of deep infiltrating endometriosis in adolescence
By Selma Oransay
Dysmenorrhea is widely observed in adolescence, and endometriosis is one of its causes. However, endometriosis diagnosis is usually made after 25 years of age. It is clear that early diagnosis and management of this progressive disease is essential and will…
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Can We Reliably Measure Sleep Quality in Women With Endometriosis?
By Özge Özkaya
The Insomnia Severity Index (ISI) and the Pittsburgh Sleep Quality Index (PSQI) lead to consistent scores comparable in women with deep infiltrating endometriosis, according to a new study published in the scientific journal Sleep Medicine. However, the cutoff values of…
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Fertility outcomes after discoid excision for colorectal endometriosis.
By Selma Oransay
Colorectal endometriosis is one of the most severe forms of deep endometriosis, composing 85% of all bowel lesions. Radical treatment is segmental resection of the bowels, which can cause postoperative severe complications such as rectovaginal fistula and voiding dysfunctions that negatively…
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Can Endometriosis Affect the Chance of Giving Birth to a Live Baby?
By Özge Özkaya
Deep infiltrating endometriosis and/or endometrioma diagnosed by transvaginal ultrasound is associated with a lower chance of giving birth to a live baby in patients undergoing their first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), according to a new…
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Should I Have Endometriosis Surgery Before IVF-ICSI?
By Özge Özkaya
The live birth rate per in vitro fertilization (IVF) or intrauterine sperm injection (ICSI) cycle was significantly reduced in women who underwent surgery to treat endometriosis before the procedures, found a new study published in the scientific journal Reproductive Sciences. “These…
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Surgery Pivotal in Improving Quality of Life in Endometriosis Patients
By Özge Özkaya
Surgery plays a pivotal role in improving the quality of life of women with endometriosis who have previously not responded to medical therapy. This is according to a new study published in the Journal of Minimally Invasive Gynecology. During the…
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By Nasuhi Engin AydinA unique approach for visualising endometriosis during surgery
By Nasuhi Engin Aydin
Dr. Jing Peng and associates from Shangai, China have made an experimental study on precise visualization of endometriotic lesions with gonadotropin-releasing hormone analog-modified indocyanine green, publishing their results in the Journal of Molecular Imaging. Surgical interventions are important aspects of…
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Ovarian adhesion prevention with polytetrafluoroethylene during endometrioma surgery.
By Selma Oransay
The World Health Organization defined infertility as the inability to conceive after 12 months of regular unprotected intercourse or after six months of fertility-focused intercourse. Depending on the chronic inflammatory character and causing adhesion formations within the peritoneum, endometriosis is…
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A herbal product has promising results in experimental endometriosis
By Nasuhi Engin Aydin
Neroli oil (bitter orange) is a nontoxic volatile substance from the flowers of Citrus aurantium that belongs to the Rutaceae family. This oil has notable anti-inflammatory effects besides potent antioxidant activity with 100% singlet oxygen scavenging activity. Contemporary pathophysiological views…
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Analysis of steroid hormone receptors in endometriotic tissues reveals chaotic results
By Nasuhi Engin Aydin
A group of researchers from academic institutions located at Australia and New Zeland, led by Dr. Holdsworth-Carson, have published their recent findings on steroid receptors in peritoneal endometriosis lesions by immunohistochemistry, in the journal Reproduvtive Biomedicine Online. Endometriosis is…
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Family history of endometriosis and its characteristics
By Selma Oransay
Depression and migraine are two familial disorders affected by menstrual cycle and endometriosis patients have an increased likelihood of suffering from these comorbidities. A correlation of endometriosis, migraine and depression has been already reporteed in the literature, however a link for…
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Embryo Morphokinetics of Endometriotic Patients by Time Lapse Monitoring
By Selma Oransay
Many studies showed adverse effects of endometriosis on oocyte quality due to increased apoptosis and dysregulation of molecular pathways related to the development and growth of granulosa cells resulting on developmental arrest in embryos of women with endometriosis. Time-lapse monitoring…
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Cells Constituting Endometriosis Have Different Properties
By Özge Özkaya
Many cell types are altered in endometriosis, found a new study published in the Journal of Pathology. The study also found that depending on the subtype of endometriosis, endometriosis cells show signatures of estrogen responsiveness, immunologic cytotoxicity, and proinflammation. Finally, it identified…
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Diagnosis and the Treatment of Postmenopausal Endometriosis
By Selma Oransay
About 190 million women around the world are diagnosed with endometriosis. The majority of the cases are between 30 and 40 years of age. After menopause, the incidence of endometriosis declines to 2-5%, and it is more common in women…
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Potential New Therapeutic Avenue for Deep Endometriosis
By Özge Özkaya
The use of lipid nanoparticles carrying methotrexate seems to be safe and feasible in women with deep infiltrating endometriosis, according to a new study published in the scientific journal Archives of Gynecology and Obstetrics. The approach could, therefore, be a new…
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Deep infiltrating endometriosis and postoperative pregnancy outcomes
By Selma Oransay
Although the current ESHRE guidelines state that there is no strong evidence to support surgical intervention to improve the spontaneous pregnancy rate in women with deep infiltrating endometriosis and advise Assisted reproduction technology irrespective of the severity of endometriosis, several studies…
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By Hale Goksever CelikNo increased risk of major postoperative complications in women operated by experienced surgeons in endometriosis centers
By Hale Goksever Celik
Recurrent surgery may be needed in up to 35% of endometriosis patients. The reason for repeated surgery may be residual or recurrent disease. In other words, multiple surgical procedures are a common phenomenon for women having endometriosis. Knowing the impact…
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Live Birth Rate for ovarian stimulation protocols after laparoscopic endometrioma cystectomy.
By Selma Oransay
The laparoscopic cystectomy of the ovaries is the first-line infertility treatment in patients with endometriomas. However, a possible diminished ovarian capacity after cystectomy with ovarian failure to respond to the gonadotropin stimuli seems an undesirable result of this procedure. Controlled…
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Perioperative complications of outpatient surgery for endometriosis.
By Selma Oransay
Surgical treatment of endometriosis plays an essential role in managing the disease. They are miscellaneous perioperative complications such as incomplete removal of the lesions, low quality of the first surgery, or incorrect approach to laparoscopic surgeries that result in increased…
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A pioneering study on clinicopathologic features of biopsies of endometriotic lesions
By Nasuhi Engin Aydin
Deep infiltrating endometriosis, where endometriotic lesions have an invasion depth of ≥5mm to the underlying tissues, is well known due to the troublesome features, peritoneal endometriosis is very common and widely distributed by superficial involvement in the pelvic visceral and…
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By Bahar YukselThe Molecular Mechanisms of how herbal medicine Actaea racemosa modulates Endometriosis Progression
By Bahar Yuksel
Increased proliferation, dysregulated apoptosis, and a pro-inflammatory and oxidative environment are the hallmarks of endometriosis. In the article published in the Journal of Molecular Sciences, penned by Livia Interdonato et al, the molecular mechanisms of the extract from a plant…
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A new classification called ENDOGRADE to rate surgical complexity in deep endometriosis.
By Selma Oransay
Correlation with patient outcomes could not be identified in most endometriosis classification systems including the commonly used revised ASRM. Therefore, in addition to grading the depth and invasion pattern of the lesions, there is a need for a classification system to…
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Preoperative flexible sigmoidoscopy in patients with deep infiltrating endometriosis
By Hale Goksever Celik
Deep infiltrating endometriosis is defined as endometriotic lesions extending 5 mm or more below the peritoneal surface. Women with deep endometriosis have rectovaginal lesions affecting the tissue adjacent to, or directly involving the rectum and/or rectosigmoid colon with a 90%…
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Does ZEB1 Gene Expression Govern Endometriosis Infiltration Pattern?
By Özge Özkaya
The expression of a gene called ZEB1 is different between different types of endometriosis, found a new study published in the European Journal of Obstetrics & Gynecology and Reproductive Biology. This could affect whether or not lesions become infiltrative. More importantly,…
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Review of neutrophil based scientific research in endometriosis
By Nasuhi Engin Aydin
Xinlei Wang and associates from Jilin University, Changchun, China, have published a comprehensive review on the pathogenetic role of neutrophils in endometriosis in a recent issue of the periodical “Mediators of inflammation”. As a common inflammatory condition where endometrial tissue…
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Moderate-to-severe Endometriosis and "The Cumulative live birth rate" in IVF Cycles
By Hale Goksever Celik
Infertility is one of the major symptoms in women with endometriosis. The incidence of endometriosis is approximately 10% in reproductive-aged women and up to 40-50% in infertile women. There are multifactorial mechanisms resulting in endometriosis-associated infertility such as anatomic distortion, impaired…
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Dienogest versus combined oral contraceptives treatment in postoperative endometriosis care
By Selma Oransay
Dienogest is a synthetic progestin derivative, like oral contraceptives, used to prevent endometriosis recurrence after surgery. Randomized clinical trials verified a significantly higher reduction in endometriotic lesions, clinical symptoms, and improved quality of life obtained when dienogest was given to…
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A Starch-Based Gel Barrier Reduces Pain and Improves Fertility After Endometriosis Surgery
By Özge Özkaya
The development of pain was reduced in women with endometriosis who underwent surgery for deep infiltrating endometriosis (DIE) resection and the "gel barrier 4DryField® PH" was used during the operation, according to results from a randomized controlled trial. Moreover, fertility was improved. "4DryField® PH"…
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Postoperative outcomes of laparoscopic rectosigmoid resection for bowel endometriosis.
By Selma Oransay
Rectosigmoid endometriosis comprises 80-85% of all bowel endometriosis cases and can be localized in the rectovaginal septum, uterosacral ligaments, retro-cervical region, and parametrium. Symptoms of rectosigmoid endometriosis include abdominal bloating, constipation-diarrhea, lower-back pain, dyschezia, and sometimes cyclic rectal bleeding. Minimally…
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Pain Scoring System for Deep Endometriosis
By Selma Oransay
The numeric pain scale is commonly used to interpret pain score values. According to the National Comprehensive Cancer Network guidelines, pain scores of 4-7 points indicate moderate, and 8-10 points indicate severe pain. Patients with a local pain score of…
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Preoperative MRI Scoring System Could Ensure Women Are Fully Informed
By Özge Özkaya
The Deep Pelvic Endometriosis Index is able to predict the length of surgery and hospital stay as well as complications following surgery including voiding dysfunction, according to a new multicenter cohort study, the results of which were published in The Journal…
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Nutritional recommendations for endometriosis patients
By Eylül GÜN
Diet and lifestyle factors have been implicated in the development and progression of endometriosis, in addition to genetic determinants. Piecuch et al. from Poland conducted a review study discussing the importance of different nutrients and nutritional recommendations in endometriosis. The…
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The effect of glucocorticoid use on clinical pregnancy rates
By Selma Oransay
The preference to use glucocorticoids such as dexamethasone, prednisone, and methylprednisolone, along with IVF-ET cycles is due to the diminishing inflammatory response and suppressing immunity. Thus, while autoimmune diseases are suppressed with glucocorticoid administration, the success rate in the implantation…
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Another New Approach Could Help Diagnose deep Infiltrating endometriosis
By Özge Özkaya
Elastography could help distinguish deep infiltrating endometriosis (DIE) nodules from non-endometriotic tissue at different locations, according to a new study published in Ultraschall in der Medizin - European Journal of Ultrasound. The potential of the technique in improving the diagnosis…
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Deep Infiltrating Endometriosis and Adenomyosis have different genetic pathways
By Bahar Yuksel
It is still not defined whether adenomyosis is also a deep endometriosis component or not. In the study conducted by Marshall et al, the researchers compared the gene expression patterns between deep infiltrating endometriosis (DIE) and adenomyosis uteri in order…
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Surgery for Deep Endometriosis
By Selma Oransay
In recent years, minimally invasive surgery has gained popularity, providing the best results in gynecologic cancers and deeply infiltrated endometriosis. With the help of a high-definition camera displayed on a TV monitor, the small structures are enlarged 4-7 times and…
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Integrative medical management of endometriosis
By Selma Oransay
This lecture entitled "Integrative Medical Management of Endometriosis" was presented by Dr. Pinar Kodaman, Director of the endoscopic reproductive surgery program and Assoc. Professor of Clinical ObGyn and Reproductive Sciences at the Yale School of Medicine. In addition to surgery which…
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Which surgery for deep endometriosis? Laparoscopic shaving or rectal resection?
By Selma Oransay
This keynote lecture entitled "Deep endometriosis: The place of laparoscopic shaving" was presented by Dr. Jacques Donnez, the director of the infertility research unit at the Catholic University of Louvain, Brussels, Belgium, at the Annual International Medical Conference of the Endometriosis Foundation…
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First-line surgery or first-line ART: A real challenge both for the clinicians and infertile women having DIE without colorectal involvement
By Hale Goksever Celik
Deep infiltrating endometriosis (DIE) is defined as the presence of endometriotic lesions over 5 mm in depth under the peritoneal surface. These women suffer from chronic pelvic pain, dysmenorrhea, dyspareunia, chronic pelvic pain, bloody or painful bowel movements, and infertility. There…
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The enhanced invasiveness, migration and the development of adenomyosis: Importance of M2 macrophages
By Hale Goksever Celik
Adenomyosis is the ectopic presence of endometrial stromal and glandular cells inside the myometrial tissue. Adenomyosis is diagnosed in women with gynecological problems with an incidence of 20%, although it is encountered much more frequently in hysterectomy specimens. Among many…
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New adapted ESHRE guidelines for endometriosis.
By Selma Oransay
Eun Hee Yu and Jong Kil Joo from the Department of Obstetrics and Gynecology of Pusan National University School of Medicine, Republic of Korea, published a commentary on the 2022 ESHRE guidelines, referring to the representative changes and important updates in a recently…
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A Multidisciplinary Surgical Team Is a Must in Deep Endometriosis Surgery
By Özge Özkaya
Endometriosis must be managed by a team of multidisciplniary specialists, especially in case it causes damage to the digestive tract, according to a new study published in the journal Archives of Gynecology and Obstetrics. According to the authors, the presence…
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A review of multimodal imaging modalities for endometriosis.
By Selma Oransay
Since there is a lack of non-invasive biomarkers to diagnose endometriosis clinically, imaging techniques such as transvaginal ultrasonography and MRI have significant importance in preoperative endometriosis diagnosis. These imaging techniques allow appropriate surgical planning before laparoscopic excision, especially in deeply…
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Postoperative pregnancy outcomes in women with deep infiltrating endometriosis
By Hale Goksever Celik
Subperitoneal invasion of endometriotic lesions exceeding 5 mm in depth is named "deep infiltrating endometriosis' and can be located on uterosacral ligaments, in the intestine, vagina, bladder, and ureter. Women with deep infiltrating endometriosis suffer from pelvic pain and infertility most…
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Comparison of two surgical approaches for endometriosis.
By Selma Oransay
Endometriosis is one of the causes of infertility in women. But the pathophysiology of infertility caused by endometriosis is not yet clear. Hormonal disorders, abnormal peritoneal function, distorted pelvic anatomy, and multiple cesarean deliveries are among the accused. Dr. Li…
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How Good is Ultra-Long GnRH-a Treatment Before IVF for Women With Endometriosis?
By Özge Özkaya
Pretreatment with ultra-long gonadotropin-releasing hormone agonist (GnRH-a), i.e. for at least three months before in vitro fertilization (IVF), has an adverse effect on patient pregnancy outcomes with endometriosis, according to a meta-analysis of the literature published in the Journal of…
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Comparison of different IVF stimulation protocols for pregnancy success in infertile endometriosis patients
By Hale Goksever Celik
Women with endometriosis may suffer from reproductive problems up to an incidence of 50%. Several pathophysiological mechanisms including anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis and sperm movements are the most responsible for the development of endometriosis-associated infertility.…
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The effectiveness of acupuncture in the treatment of dysmenorrrhea
By Selma Oransay
Asymptomatic endometriosis does not adversely affect women's quality of life and mental health. But the quality of life of women with endometriosis who suffer endometriosis-related pelvic pain, dysmenorrhea, dyspareunia, and dysuria declines as they become more susceptible to anxiety and…
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The optimal endometrial preparation protocol in FET cycles of women with endometriosis.
By Selma Oransay
Endometriosis can create infertility and may require treatment with assisted reproductive technology (ART) to induce pregnancy. However, the current literature rarely discusses the optimal endometrial preparation protocol in thawed-frozen embryo transfer (FET) cycles for endometriotic patients. Dr.Jin. group from the Reproductive…
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Evaluation of the postoperative disability in women with endometriosis.
By Selma Oransay
Endometriosis is a chronic disease with a prevalence of 4,4% in women of reproductive age. It is also estimated that 23,8 of infertile women have endometriosis. Pelvic pain, dyschezia, dysmenorrhea, and dysuria are the symptoms of this disease that negatively…
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The emotions and experiences of women with endometriosis during and after pregnancy
By Eylül GÜN
It is well-known that endometriosis patients have a high rate of infertility and a hard time getting pregnant compared to women without endometriosis. Despite the belief that pregnancy can alleviate endometriosis symptoms, some studies have shown that women with endometriosis…
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Women With More Severe Endometriosis Have Fewer Eggs
By Özge Özkaya
Severe endometriosis negatively affects ovarian response and the quality of oocytes and embryos, according to a new study published in JBRA Assisted Reproduction. However, the rate of fertilization does not seem to be affected by endometriosis stage. These findings could…
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Machine learning based potential biomarkers
By Bahar Yuksel
To explore potential biomarkers for an accurate diagnosis and treatment, and to elucidate the mechanism of endometriosis, Yi Huang et al, analyzed gene differences between eutopic and ectopic endometrium and the status of the immune microenvironment., and published their results in the…
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How accurate is ultrasonography in evaluating deep infiltrating endometriosis?
By Eylül GÜN
Deep infiltrating endometriosis (DIE) appears to be the most severe form of endometriosis comprising 15-30% of all endometriosis patients. The difference in the presentation of the lesions ranges from simple adhesions to infiltrative nodules. Even though there is no consensus…
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Ovarian endometriomas, ovarian reserve, oocyte quality and IVF/ICSI outcomes
By Selma Oransay
Surgery and assisted reproductive technology (ART) are the preferred treatments for endometrioma in infertile patients. When ART is considered, surgery may seem to have no advantages, as it may not improve pregnancy outcomes and may carry the risk of decreasing…
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Efficacy of Uterine Artery Blockage in Endometriosis Management
By Nasuhi Engin Aydin
Dr. Li Ma and associates from Liaoning, China have published their results of a computerized database search on the role of uterine artery embolization in endometriosis in a recent issue of the periodical “Computational Intelligence and Neuroscience”. Currently, the management…
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Opioid use following operation for endometriosis or pelvic pain
By Hale Goksever Celik
Women with endometriosis have pain in the form of dysmenorrhea, dyspareunia, and chronic pelvic pain, and they have a diminished quality of life depending on the severity of pelvic pain. Opioids have been preferred in many patients suffering from pain,…
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Non-hormonal medication for endometriosis-associated pelvic pain
By Selma Oransay
The thought of benefiting from non-hormonal therapy in endometriosis pain is based on the pathophysiological findings that include angiogenesis, fibrosis, the presence of inflammatory cytokines and immune cells, apoptosis, and stem cell theory. But the effect of this treatment in…
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Does endometrioma size have an effect on IVF/ICSI outcomes?
By Hale Goksever Celik
Assisted reproductive technologies including IVF/ICSI can be suggested as the therapeutic option in women with endometriosis-associated infertility. In literature, there is a controversy regarding the influence of endometrioma size on IVF/ICSI outcomes. The group led by Drs Chapron and Santoulli…
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Social Support is a Predictor of Resilience in Women with Endometriosis
By Özge Özkaya
Satisfying social support and good mental health are key resources for resilience among patients with endometriosis, according to a new study published in the Journal of Clinical Medicine. “The results of this study may assist in the identification of women…
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Endometriosis and the cumulative live birth rate in IVF cycles.
By Hale Goksever Celik
Infertility is one of the symptoms encountered in up to 40-50% of women with endometriosis. There are several pathophysiological theories suggesting the development of endometriosis-associated infertility. Assisted reproductive technology (ART) using in vitro fertilization and embryo transfer (IVF-ET) has been…
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Parametrial endometriosis and postoperative voiding dysfunction.
By Selma Oransay
Parametrium constitutes a complex connective tissue containing blood vessels, the ureter, and the inferior hypogastric plexus, that extends from the lateral surface of the cervix and vagina to the lateral pelvic wall. Parametrial endometriosis may involve the vessels, nerves, and…
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The association between severe endometriosis and venous thromboembolism
By Hale Goksever Celik
For clarifying the issue of whether endometriosis patients are at risk for venous thromboembolism due to both their local immune and inflammatory responses and hormonal treatments, Wiegers et al, from the Netherlands, published an explorative cohort study entitled “Risk of…
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Study Identifies Factors Associated With Risk of UrinaryTract Endometriosis Recurrence
By Özge Özkaya
Being younger than age 25 and having an autoimmune disease are significant predictors of the recurrence of urinary tract endometriosis after surgery according to a new study published in the Journal of Minimally Invasive Gynecology. Adjuvant hormonal therapy, on the…
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To Remove the Ovary(ies) or Not During Hysterectomy for Endometriosis
By Selma Oransay
Some surgeons prefer empiric bilateral salpingo-oophorectomy during the hysterectomy of women with endometriosis based on the knowledge that endometriosis is stimulated by endogenous estrogens, as leaving the ovaries in situ may increase the possibility of endometriosis recurrence and pelvic pain.…
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Endometriotic cyst fluid and the postoperative recurrence of endometriosis
By Nasuhi Engin Aydin
Dr. Xinxin Xu and colleagues from the Department of Obstetrics and Gynecology, School of Medicine, Zhejiang University, China, published their research on the viability of endometrial cells in ovarian cyst fluids in a recent issue of “Journal of Ovarian Research”.…
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Transvaginal Ultrasound Could Be Sufficient to Properly Diagnose Deep Endometriosis and Ovarians Endometriomas
By Özge Özkaya
Following the International Deep Endometriosis Analysis consensus can improve the accuracy of transvaginal ultrasound to diagnose ovarian endometriomas and deep infiltrating endometriosis, according to a new study published in the scientific journalUltrasound in Obstetrics & Gynecology. “ (…) at this…
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The effects of resveratrol on endometriotic cells
By Eylül GÜN
The current treatment methods for endometriosis still carry recurrence risks and side effects from medications. Herbal medicine has been investigated and used as an additional alternative method. Derived from several plants and found in some dietary sources, resveratrol is a…
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Gluten Intake May Not Have an Effect on Endometriosis
By Özge Özkaya
Carbohydrate quality and certain types of fiber such as total vegetable and cruciferous vegetable fiber seem to be associated with endometriosis in women before menopause, found a new study published in the Journal of Nutrition. According to the study, it…
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Combined "Platelet-to-lymphocyte ratio and CA125" may be promising predictor for adhesions
By Nasuhi Engin Aydin
Drs. Guo & Zhang from the Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China published their manuscript on the importance of combined "platelet-to-lymphocyte ratio and CA125 level" as a biomarker of endometriosis in a recent…
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New Endometriosis Self-Assessment Tool Could Help Women Seek Timely Medical Attention
By Özge Özkaya
Researchers from Korea developed a self-assessment tool that may allow women to determine their risk of endometriosis. They described the tool in an article they published in the scientific journal Obstetrics & Gynecology Science. “The devised tool appears valid and…
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Research Identifies Blood Proteins Associated With Endometriosis in Adolescents
By Özge Özkaya
Proteins related to angiogenesis or the formation of new blood vessels and cellular migration are enriched and more active in the blood of adolescents with endometriosis compared to healthy controls. These are the findings of a new study published in…
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Ovarian Endometrioma Reduces the Chance of a Successful Pregnancy With IVF
By Özge Özkaya
Ovarian endometrioma significantly decreases ovarian reserve or the capacity of the ovaries to produce eggs that are able to be fertilized and give rise to a successful pregnancy. This is according to a study published in the scientific journal Medicine.…
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Postoperative outcomes of deep intestinal endometriosis surgery.
By Selma Oransay
Invasion of endometriotic lesions to the bowels' mucosal and/or muscular levels is called intestinal deep endometriosis. These lesions are most frequently found in the rectosigmoid colon, followed by the rectum, ileum, appendix, and caecum. The optimal surgical approach to intestinal deep…
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Are my Eggs Good Enough for IVF?
By Özge Özkaya
There does not seem to be any difference in the rate of live births between women with endometriosis who became pregnant following IVF using their own eggs or eggs obtained from a donor. This suggests that oocyte quality may not…
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Who Is Diagnosing my Endo?
By Özge Özkaya
It is possible to acquire the skills necessary to diagnose endometriosis lesions as well as adenomyosis using three-dimensional rectosonography after a short learning period in an expert radiology center. This is according to a new study by French researchers published…
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Does endometrioma affect ovarian reserve to reach pregnancy and birth?
By Hale Goksever Celik
Endometrioma occurs in approximately 17-44% of women with endometriosis. These women suffer from dysmenorrhea, dyspareunia, chronic pelvic pain, and also infertility. Although the exact mechanism explaining endometriosis-associated infertility has not been elucidated, distorted pelvic anatomy, impaired ovarian function, altered microenvironment-endometrial receptivity,…
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Comparison of imaging techniques for estimating the depth of bowel wall infiltration by endometriosis.
By Selma Oransay
The surgical removal of deep endometriosis is the cornerstone of the management. However, the decision for the varying surgical approach types ranging from conservative management (shaving) to segmental or discoid resection depends on the depth of infiltration within the bowel wall, which…
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Self-Management Strategies for Endometriosis
By Özge Özkaya
Many self-management strategies for endometriosis are not more effective at reducing the symptoms of the disease compared to placebo or hormonal therapies, according to a new study published in the journal Reproductive Sciences. The authors, therefore concluded that “no recommendations…
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Atherosclerosis is augmented in laboratory mice by experimental endometriosis
By Nasuhi Engin Aydin
Dr. Taylor group from Yale School of Medicine, New Haven, CT, USA has published their experimental study in the "American Journal of Obstetrics & Gynecology" on atherosclerosis following endometriosis induction in laboratory mice. The basic inflammation process in endometriosis patients…
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Challenges of Living With Endometriosis and Possible Solutions
By Özge Özkaya
A new study published in the scientific journal BMC Women's Health reviewed the challenges of living with endometriosis and possible solutions for women with the disease. The findings of the study highlight the need for a multidisciplinary approach to treating…
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A French National Study Concerning The "Recovery Protocol" After Deep Infiltrating Endometriosis Surgery.
By Selma Oransay
In recent years especially for complex surgeries, enhanced recovery after surgery (ERAS) programs have been implemented in several surgical specialties. This is based on a multimodal and multidisciplinary approach centered on the patient’s perioperative situation designed to improve patient management and reduce…
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Imaging Techniques Able to Predict Depth of Endometriosis Before Surgery
By Özge Özkaya
Transvaginal ultrasound (TVUS) and pelvic magnetic resonance imaging (MRI) performed by a specialist can accurately predict the depth of rectosigmoid endometriosis before surgery, according to a new study published in the Journal of Minimally Invasive Gynecology. Both approaches are similar…
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Diaphragmatic endometriosis
By Selma Oransay
Diaphragmatic endometriosis is a rare clinical condition that may show signs and symptoms like chest pain, right upper quadrant abdominal pain, shoulder pain, pleuritic pain, hemothorax, pneumothorax, hemoptysis, and thoracic endometriosis syndrome while the major part of the patients is…
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Nerve-sparing technique for deep infiltrating endometriosis and its impacts on pelvic organ and sexual functions.
By Selma Oransay
Deep infiltrating endometriosis and involvement of parametrium cause severe pelvic pain and dysfunction of some pelvic organs resulting in a reduction in women's quality of life. Although surgery for DIE aims to relieve pelvic pain, entering into the posterior parametrial…
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Effects of Bowel Endometriosis Surgery on Mode of Delivery
By Özge Özkaya
Less than a third of doctors counsel women about the possible effects of surgical treatment of bowel endometriosis on their mode of delivery should they become pregnant, according to a new study published in the Journal of Obstetrics and Gynaecology.…
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How Likely Am I to Conceive After Endometriosis Surgery?
By Özge Özkaya
Women with superficial peritoneal endometriosis and just one type of lesion are more likely to conceive after surgery, according to a new study published in the International Journal of Gynecology and Obstetrics. This is important because patients will be better…
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Importance of Language in Communicating Endometriosis Pain
By Özge Özkaya
Language is of great importance for women with endometriosis to communicate their pain to their doctor, according to a new study published in Frontiers in Global Women's Health. The study also found that additional tools are needed to help women…
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Pain During Sex in Women With Endometriosis
By Özge Özkaya
Pain during intercourse or dyspareunia due to endometriosis manifests itself in multiple forms such as deep, introital, and/or positional. Pain can also occur at orgasm and during and/or after intercourse. These are the findings of a systemic literature review published…
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Preoperative Neutrophil-to-Lymphocyte Ratio for prediction of postoperative pregnancy
By Hale Goksever Celik
Among women with endometriosis, 30 to 50 percent are estimated to have infertility, and 25-50% of infertile patients are found to have endometriosis. Anatomic distortion, diminished tubal peristalsis, diminished sperm movements, dysfunctional folliculogenesis, luteal phase dysfunctions, and alterations in endometrial…
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Does Surgery Improve the Digestive Symptoms of Endometriosis?
By Özge Özkaya
Women with deep infiltrating endometriosis involving the bowels have the most significant improvement in gastrointestinal symptoms following surgery. This is according to the findings of a comparative retrospective study in almost 1,500 women. “Women with severe bowel symptoms and deep…
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Could Cannabis Be Recommended to Manage Endometriosis?
By Özge Özkaya
It is not possible to recommend cannabis-based products to patients with endometriosis because there is not enough evidence supporting their benefits, according to a new study published in the Journal of Minimally Invasive Gynecology. Cannabis-based products have been suggested as…
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How does adenomyosis affect IVF outcomes?
By Hale Goksever Celik
Adenomyosis is defined as the localization of endometrial tissue in the muscle layer of uterus. Several theories have been proposed to explain the reasons of adenomyosis-associated infertility including uterine dysperistalsis, abnormal transportation of sperm in the uterine cavity, and embryo…
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Molecular alterations in endometriosis pathogenesis
By Eylül GÜN
Endometriosis has been in our lives for decades, however little is known about its pathogenesis making it hard to diagnose and manage. A review study conducted by Balasubramanian et al. from India reveals all the characteristics and the underlying conditions…
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Phytoestrogens could have promising effects in endometriosis management
By Nasuhi Engin Aydin
Dr. Bartiromo and associates from Milan, Italy published a systematic review on phytoestrogens and endometriosis in the periodical “Nutrients”. Endometriosis has features of chronic inflammation based on uncontrolled hormonal response and immune-mediated dysfunctions. Estrogens are endocrine and paracrine agents that could yield…
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Resveratrol for endometriosis
By Bahar Yuksel
Endometriosis has been studied previously about its inflammatory nature and its tendency for causing macrophage disfunction. In the study conducted by Chunyan Wang et al, the researchers analyzed the effect of a flavonoid, "resveratrol" on endometriosis lesions and the mechanism…
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The Coping Strategies of Korean Women With Endometriosis
By Özge Özkaya
Women with endometriosis adopt four main strategies to cope with the disease, according to a new study published in the journal "Research in Nursing & Health". These are gaining self-control, regaining daily routines, being emotionally supported and expressing themselves when…
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How to Reduce Pain After Laparoscopic Surgery
By Özge Özkaya
Using humidified warm gas with forced-air warming blanket during laparoscopic surgery resulted in significantly less pain in the recovery room, according to a new study published in the journal "Surgical Endoscopy". In patients with endometriosis, using humidified warm air even…
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Impact of surgery before IVF in infertile women with endometrioma
By Hale Goksever Celik
Among the women with endometriosis, 30 to 50% are estimated to have infertility. On the contrary, among women who present with infertility, 25 to 50% are estimated to also have endometriosis. Several mechanisms have been proposed to explain the association…
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Dienogest treatment increases the risk of Endometriosis reoperation rate
By Selma Oransay
The common and accepted therapy of endometriosis is surgery, however medical treatment such as nonsteroidal anti-inflammatory drugs, gonadotropin-releasing hormone agonists, oral contraceptives and oral progestins are used for either relieving pain or to prevent recurrences and reoperation. Due to bone loss and…
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Best practice: How to reduce intraoperative bleeding?
By Selma Oransay
Although laparoscopic hysterectomy is a popular and common approach for removing benign uterine lesions, some technical steps especially concerning uterine artery closure depend on the surgeon's preference. Uterine artery ligation may be performed either at the uterus level, which is common…
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Technical Facts for the Prevention of Complications After Deep Endometriosis Surgery
By Özge Özkaya
There are no differences in the risk of rectovaginal fistula in women with rectovaginal endometriosis who were managed by a liberal or restrictive policy of preventive stoma according to a study by French researchers published in the Journal of Minimally…
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Non-pharmacological self-care: dietary modifications in women with endometriosis.
By Selma Oransay
The academic interest on the role of diet in endometriosis has grown due to its possible relation with inflammation, estrogenic activity, and menstrual cycles. Multiple dietary strategies and prescriptions are being used to deal with the pelvic pain and gastrointestinal…
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Resveratrol, isoflavones and puerarin have favorable in vivo results in endometriosis studies
By Nasuhi Engin Aydin
Xia Cai and associates from research units located in China published their review article on the relationship between phytoestrogens and endometriosis in the scientific periodical named “Pharmacology”. The great variation in the prevalence of endometriosis raises questions in regard to…
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Impact of adenomyosis on sexual life
By Selma Oransay
Considering the similar etiopathogenesis and pain symptoms between adenomyosis and deep infiltrating endometriosis, Alcalde et al. from the Department of Gynecology, University of Barcelona, Spain, aimed to call attention to the presence of potential sexual dysfunction not only in patients with deep…
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Postoperative Opioid use after Robotic operations for endometriosis, compared to non-endometriosis
By Bahar Yuksel
Endometriosis is a common disease in patients of fertile age, and many patients require surgery. Robotic surgery is accepted as a minimally invasive method in the management of endometriosis and other benign conditions. However, postoperative pain status and the best pain…
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Outcomes of chronic pelvic pain of endometriosis after laparoscopic surgery
By Selma Oransay
The prevalence of endometriosis is up to 35-50% among patients with pelvic pain. Among several medical and surgical options to relieve chronic pelvic pain, surgical options are the preferred method but this depends on patients' age, fertility desire, and disease…
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How Does Endometriosis Affect Patients Quality of Life?
By Özge Özkaya
Health-related quality of life is significantly lower in patients with endometriomas or deep infiltrating endometriosis compared to women without the disease. This is according to the results of a recent study in adult Spanish women that was published in the "International…
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Postoperative ovulation induction in infertile women with minimal to mild endometriosis
By Hale Goksever Celik
Infertility is an important problem that is encountered in 30-50% of women with endometriosis. Several etiopathogenetic mechanisms for the development of reproductive problems in women with endometriosis have been proposed including abnormal peritoneal microenvironment, ovarian dysfunction and/or decreased oocyte quality,…
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Adhesion Barrier Helps After Endometriosis Surgery
By Özge Özkaya
An adhesion barrier, named "4DryField® PH" significantly reduced the formation of adhesions following endometriosis surgery, according to a new study by German scientists. The formation of adhesions following endometriosis surgery is a severe problem that affects 90% of patients. The…
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Endometriosis scar disruption may lead to "spontaneous hemorrhage in pregnancy" and can be life-threatening.
By Selma Oransay
Kollikonda et al from Cleveland Clinic Women's Health Institute, Cleveland, Ohio, US penned a case report about their hemoperitoneum experience during labor, which was recently published in the "Journal of Obstetrics and Gyneaecology Canada". The aim is to warn obstetricians…
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Low-Dose Aspirin as a Potential Treatment for Endometriosis-Related Infertility
By Özge Özkaya
Treatment with low-dose aspirin could downregulate progesterone resistance and increase the expression of leukemia inhibitory factor (LIF) during the implantation window, according to a study that used a rat model of endometriosis. This, in turn, could improve endometrial receptivity and…
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The genomic linkage between ovarian cancer and endometriosis
By Eylül GÜN
Endometriosis has been proven to be the precursor of ovarian clear cell and endometrioid carcinomas, however, it is not well understood why and how endometriosis goes into malignant transformation. To address this issue, in their review article, Dr. Yachida and…
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How to predict the complications after laparoscopic bowel resection in women with endometriosis
By Hale Goksever Celik
The endometriotic lesions infiltrating the bowel wall more than 5 mm. are called "deep infiltrating endometriosis". The patients having bowel involvement may have constipation, diarrhea, tenesmus, or rectal bleeding. Surgical management is the main treatment modality to provide benefits on pain, infertility,…
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Evaluation of preoperative risk factors of ureteral endometriosis
By Selma Oransay
Endometriosis affects the urinary tract in 1% to 5.5% of the patients, and among them, bladder involvement is 70-85%, while ureteral involvement alone is 9% to 23%. Ureteral endometriosis is most commonly unilateral, especially on the left side, usually affecting…
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Endometriosis Surgery Improves Sex Life
By Özge Özkaya
Women who underwent laparoscopic resection surgery to treat their deep infiltrating endometriosis had improved sexual quality of life and health-related quality of life according to a new study published in the Journal of Minimally Invasive Gynecology. These findings are important…
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Postoperative infertility management using Endometriosis Fertility Index in endometriotic women
By Selma Oransay
"Endometriosis Fertility Index '' score, described by the World Endometriosis Society in 2017, is a robust score and assists to predict the spontaneous pregnancy rate of women with endometriosis, within 3 years after their operation. Its calculation is possible by patient…
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Progestin suppression for endometriosis before IVF
By Hale Goksever Celik
“Dienogest is a suitable and safe substitute for GnRHa pretreatment in endometriosis patients”, according to the Khalifa et al., from Egypt. Endometriosis is one of the leading reasons for infertility due to decreased oocyte/embryo quality, fertilizability, tubal function, and aberrant endometrial…
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Endometriosis in intestine! Segmental resection or linear nodulectomy?
By Bahar Yuksel
Intestinal involvement of endometriosis is common, and the incidence was defined between 45-56%. Previous studies investigating the role of surgery in the management of intestinal endometriosis reported improvement of life quality in up to 95% of cases following surgery. However,…
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A gentle touch on nerves affects dyspareunia
By Bahar Yuksel
Endometriosis is a common disorder among women. Previous studies reported endometriosis-related deterioration of the quality of life. Deep dyspareunia is a common symptom of endometriosis and young patients face dyspareunia twice as much. Surgical treatments are alternative to medical therapies in cases…
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Improvement of the quality of life after surgery for deep infiltrating endometriosis.
By Selma Oransay
Deeply infiltrating endometriosis is the most severe form among the endometriosis types. The required laparoscopic approach is the appropriate excision of endometriotic foci from pelvis, by consideration of failure and side effects of the medical treatments. The specialist endometriosis centers…
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Problems in the treatment of deep infiltrating endometriosis
By Bahar Yuksel
The Deep Infiltrating Endometriosis (DIE) is very aggressive in nature with infiltrating the whole pelvic, colon, rectum, bladder, ureter, and pelvic wall. D’Alterio and colleagues analyzed the advantages and disadvantages of both medical and surgical therapies for DIE. The authors…
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Postoperative long-term estro-progestin therapy for endometrioma
By Selma Oransay
After the removal of ovarian endometriomas, the major concern is the high recurrence rate of symptoms and endometriotic cysts. The estimated recurrence rate of endometriomas is up to 50% at 5 years after surgery. To prevent the recurrence, postoperatively long-term…
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Fertilization rate and pregnancy outcome in IVF cycles of endometriosis.
By Selma Oransay
Endometriosis affects the pelvic cavity, uterus, ovaries and causes impaired fertility as a result. The chronic inflammatory nature of this disease negatively impacts the oocyte quality, maturation, and fertilization. Obviously, fewer oocytes can be harvested in the IVF cycles of…
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Postoperative treatment and pregnancy points to decreased recurrence risk for ovarian endometriosis
By Hale Goksever Celik
Endometriosis is a disease most frequently diagnosed in women of reproductive age and negatively affects the quality of life. The most common localization for endometriosis is ovaries with a prevalence of 17-44%. Laparoscopic ovarian cystectomy performed as excision or ablation…
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Oxygen deprivation (hypoxia) has a critical role in the pathogenesis and progression of endometriosis
By Nasuhi Engin Aydin
Dr. Wan-Ning Li and associates from academic institutions from Taiwan have published their review paper on the role of hypoxia and possible therapeutic outcomes in the medical journal named "Reproduction" recently. Endometriosis is an important ailment with huge medical and social…
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Cancer risk Evaluation in Korean Endometriosis Cohort
By Bahar Yuksel
The relationship between endometriosis and cancer has always been challenging. The previous studies revealed an increased risk in endometriosis-associated ovarian cancers regarding the alterations in cancerogenic genes or by the effect of iron and hem coming with retrograde menstruation and…
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Ovarian, breast and endometrial cancer coexisting with endometriosis.
By Selma Oransay
The invasive nature of endometriosis results in calling the disease " benign cancer". The transformation of endometriosis to malignancy is rare, but when compared to the general population, the relative risk of developing ovarian cancer is 4.2 times greater especially…
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The role of hormonal treatment after endometriosis surgery
By Bahar Yuksel
Postoperative hormonal suppression after endometriosis surgery still does not have a uniform approach. The meta-analysis study conducted by Zakhari et al. aimed to find a significant answer regarding this burden. They analyzed the database systems including MEDLINE, Embase, Cochrane CENTRAL,…
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By Irem OnurThe association between body size and endometriosis
By Irem Onur
Until today there have been few studies investigating body size in childhood and adolescence in women with endometriosis. A new study published recently in the journal Acta Obstetricia et Gynecologica Scandinavica provides further evidence of the associations between endometriosis, body…
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Live Birth Rate in Women Who Underwent Fresh Embryo Transfer Using Freshly Retrieved Donor Oocytes
By Hale Goksever Celik
One of the important clinical findings in women with endometriosis is reproductive problems. Infertility can be encountered in up to 50% of women with endometriosis and up to 50% of women with infertility can be diagnosed with endometriosis. Several pathophysiologic…
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Postoperative pregnancy rate in infertile women with deep infiltrating endometriosis
By Hale Goksever Celik
Deep infiltrating endometriosis (DIE) is fibrous/muscular infiltration of organs and anatomical structures containing endometrial tissue below the peritoneum regardless of the depth of infiltration. Another definition describes DIE as infiltration of the peritoneum by endometriotic lesions deeper than 5 mm. Pain,…
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Urological Challenges in Endometriosis Surgery - Guenter Noe, MD
By Özge Özkaya
In this presentation, Dr. Guenter Noé, Head of Department of Rheilandklinikum Dormagen in Germany talks about endometriosis affecting the urinary tract. Dr. Noé starts by describing the different parts of the urinary tract that can be affected by endometriosis including…
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Implantation failure in endometriosis patients - Jovana Lekovich, MD., PhD.
By Hale Goksever Celik
Endometriosis is one of the leading reasons for infertility due to decreased oocyte/embryo quality, fertilization ability, tubal function, and aberrant endometrial receptivity. Whether this failure is caused by oocyte/embryo or eutopic endometrium is one of the investigated topics in endometriosis…
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Fixing holes: prevention and treatment of complications - Jon Einarsson, MD, MPH
By Selma Oransay
Dr. Einarsson shared his operating room video screens during his speech for discussing four major complications (ureter, bladder, bowel, and vascular) of endometriosis surgery and the ways to repair them. Fixing the ureter damage: Endometriotic nodules may settle on the tract…
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In vitro fertilization protocols in endometriosis patients - Pinar Kodaman, MD., PhD.
By Hale Goksever Celik
Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis, and sperm movements. Even though the disease stage and presence of endometrioma is negatively correlated with infertility, it is unpredictable which women…
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Endometriosis and the sexual relations of the couples
By Selma Oransay
From the viewpoint of endometriotic women, the pain during the penetration is not the only complaint. They also have growing depression and anxiety leading to difficulties with their social and sexual relationship, work, and study. The emotional impact of sub-infertility,…
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Comparison of diagnostic accuracy of imaging modalities for the deep infiltrating endometriosis
By Selma Oransay
The treatment of deeply infiltrated endometriosis (DIE) is usually personalized and the potential success for the available therapeutical options is dependent on early and accurate diagnosis. Laparoscopy is the gold standard for the diagnosis of DIE. Other non-invasive diagnostic methods…
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A new Marker to Detect Endometriosis and Its Severity?
By Özge Özkaya
Macrophage migration inhibitory factor (MIF) could be a novel marker that could help diagnose endometriosis as well as to detect its severity. This is according to a new study by researchers in Egypt, published in the scientific journal "BMC Women’s Health".…
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Can a grape ingredient, resveratrol, be the promised warrior to defeat endometriosis?
By Bahar Yuksel
Endometriosis is a chronic estrogen-dependent disorder and has a known relationship with angiogenesis, inflammation, and oxidative stress. Resveratrol is a part of a "polyphenol" compound which are thought to act like antioxidants, protects the body against damage. This compound is normally…
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Indocyanine green in endometriosis surgery
By Selma Oransay
Recently, indocyanine green is well studied and used safely in real-time perfusion to organs or tissues, after taking into consideration its binding capacity to the plasma proteins. The usefulness and the effectiveness of near-infrared camera guided indocyanine green is proved with…
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By Dr. Youngran ParkOsteopontin and Endometriosis
By Dr. Youngran Park
Although characterized as a benign disease, some properties of endometriosis mimic malignant tissues such as proliferation, cell invasion, and metastasis. Osteopontin, also called secreted phosphoprotein 1, is one of the important molecular targets in cancer progression and metastasis. Osteopontin has been…
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By Ellen TumimbangNon-coding RNAs and Endometriosis
By Ellen Tumimbang
Non-coding RNAs may have a fundamental role in the development of endometriosis. Non-coding transcripts have regulatory roles in the expression of protein-coding genes, thus regulate several signaling pathways. Based on their length, these non-coding RNAs are classified into two main classes:…
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An animal model of endometriosis reveals stress related disturbed vitamin D - vitamin D receptor axis
By Nasuhi Engin Aydin
Lopez and colleagues from academic institutions of Puerto Rico published their experimental endometriosis findings on female rats regarding the effect of stress on vitamin D-vitamin D receptor systems and recently published their findings in "Reproductive Sciences". The group previously showed…
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Effect of Endometriosis on IVF Success Rates
By Özge Özkaya
Endometriosis lowers the rate of cumulative live births during in vitro fertilization (IVF). However, this is due to a lower number of embryos being available for transplantation rather than their quality. This is according to a study published in the "Journal…
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Endometrium and HOXA 10 gene
By Ellen Tumimbang
Homeobox genes are transcription factors containing a conserved DNA sequence that encodes homeodomain which has a helix-loop-helix-turn structure. The homeodomain is responsible for recognizing and binding specific DNA sequences to regulate the expression of target genes. There are at least…
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Deep Endometriosis or Recto-uterine Obliteration Without Endometrioma
By Selma Oransay
The diagnostic help of ultrasound is increasing by its ability to diagnose deep infiltrating and rectouterine pouch obliteration in patients who are suffering from chronic pelvic pain. Clinicians are used to evaluating the rectal and parametrial areas of the endometriotic…
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The advantages of combined vaginal-laparoscopic approach on voiding dysfunction for rectovaginal endometriosis
By Irem Onur
The patients with rectovaginal endometriotic nodules with extensive vaginal infiltration who are managed combined vaginal-laparoscopic approach have a lower risk of postoperative bladder dysfunction when compared to surgery via laparoscopy alone. This is according to a manuscript published in the…
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New Rat Model of Endometriosis Could Help Researchers Develop New Treatments for the Condition
By Özge Özkaya
Researchers in Belgium developed a new rat model of endometriosis. The animals showed signs of ongoing pain meaning that the model could provide a tool for researchers to develop potential new ways to treat the different symptoms of the condition…
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The impact of laser vaporization on reproductive outcomes in women with endometrioma
By Hale Goksever Celik
Despite extensive research, the optimal method for the management of endometriosis still remains unclear. Excisional surgery is claimed with a more favorable outcome than drainage and ablation regarding the recurrence of disease and symptoms. On the other hand, cyst vaporization…
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By Yu YuEndometriotic mesenchymal stem cells may promote endometriosis
By Yu Yu
The cause of endometriosis is still debatable. Many researchers have accepted that retrograde menstruation, where the endometrial fragments released during menstruation attach and colonize the ectopic locations, is the most plausible reason. However, the numbers just do not add up.…
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Prevalence, Risk factors and Management of Bowel Fistula after Rectosigmoid Surgery for Deep Endometriosis
By Selma Oransay
Bowel fistula is a severe complication after the colorectal endometriosis surgery, but little is known about its prevalence, and reports on large series are lacking. To discuss specific management on colorectal deep endometriosis, Roman et al. conducted a retrospective study…
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Reproductive capacity and recurrence rate after surgery for Stage III/IV endometriosis
By Bahar Yuksel
If gaining fertility back is the main goal, the surgical removal of endometriosis lesions is globally recognized as first-line therapy. Even though, pre- and postoperative hormone therapy leads to a significant decrease in the spread of the disease measured with the…
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Early maternal separation and endometriosis progression in adult mice
By Hale Goksever Celik
The quality of life in the women affected by endometriosis depends on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Although several studies have been performed to investigate the underlying pathophysiologic mechanism, it…
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Cancer-associated mutations and endometriosis
By Ellen Tumimbang
Endometriosis is thought to benign gynecological disease. However, recent studies compiled in this review paper suggest that spontaneous somatic mutations are driven to occur during the cyclic bleeding resulting in endometriosis tissue undergoing repeated tissue injury and repair. Mutations are…
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Cabergoline or Progesterone not Effective in Rat Model of Endometriosis
By Özge Özkaya
Oral treatment with cabergoline or micronized progesterone for four weeks is not effective in the regression of endometriotic implants in a rat model of the disease. This is according to a study published in the "Journal of Investigative Surgery". Cabergoline…
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Race, socioeconomic status, and health
By Dr. Youngran Park
Racial disparities in health have been long noted in the United States. The differences in socioeconomic status across racial groups are a major contributor to racial disparities in health. However, race reflects multiple dimensions of social inequality. Understanding and effectively…
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Diagnosis and treatment algorithm for endometriosis
By Selma Oransay
Endometriosis is a chronic and progressive disease that affects 25-30% of women between 25-35years, clinicians commonly experience during their gynecologic practice. However, the diagnosis is still late or sometimes incorrect, and this creates severe health problems and worse outcomes. A…
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Endometriosis surgery and future pregnancy complications
By Selma Oransay
Endometriosis is one of the known diseases for infertility in the reproductive period of women. Several studies revealed that endometriosis itself maybe the reason for some unfavorable obstetric outcomes. Localization, the type of endometriotic lesions, and the stage of endometriosis…
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Risk Factors Associated with Ureteral Endometriosis
By Özge Özkaya
Patients with severe endometriosis, uterosacral ligament deep involvement with endometriosis lesions of 3 cm in diameter or more, and the presence of previous endometriosis surgery have a significantly higher risk of having ureteral endometriosis. This is according to a study…
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By Timur SeckinTransvaginal sonography for predicting the distance between rectosigmoid endometriosis and the anal verge
By Timur Seckin
For optimal surgery, pre-surgical assessment of the distance between rectosigmoid deep endometriosis lesions and the anal verge (Lesion to Anal Verge Distance-LAVD) is recommended by many specialists. A group of researchers from Norway, Austria, and Australia studied the accuracy of…
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Surgical approach to rectovaginal endometriosis.
By Selma Oransay
Recto-vaginal endometriosis incidence is estimated at 3.8%-37% among women with endometriosis and when it exists it's a part of deeply infiltrated endometriosis, thus advance stage endometriosis. Raimondo et al. from the Department of Obstetrics and Gynecology of the University of…
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Recurrence following surgery for subtypes of endometriosis
By Hale Goksever Celik
Endometriosis is a disease identified by the location of endometrial stromal and glandular cells outside the uterine cavity. It is considered as a gynecological disease of reproductive-aged women. Three subtypes of endometriosis are peritoneal endometriosis which defines the endometriotic lesions…
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A Routine Pelvic Ultrasound Examination Should Include an Evaluation for Endometriosis
By Özge Özkaya
Routine pelvic ultrasound examination should be extended beyond the uterus and ovaries into the posterior and anterior pelvic compartments, according to Australian doctors. With such examinations, deep infiltrating endometriosis nodules can be searched, say the authors, allowing women to be…
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Long-term Pregnancy Results after Surgical Removal of Endometrioma
By Irem Onur
Sun et al., from China, investigated the pregnancy outcomes and the related factors in patients with endometrioma and stage III-IV endometriosis along with a long-term follow-up postoperatively. Their study has recently been published in the journal named "Advances in Therapy".…
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Can Controlled Trials Help Surgeons Decide on Best Way to Treat Endometriosis-Associated Pain?
By Özge Özkaya
It may not be realistic to base the decision on the best way to surgically treat pain in a woman with endometriosis on the results of surgical randomized controlled trials. This is according to a study by researchers at the…
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Does Getting Pregnant Really Help When You Have Endometriosis?
By Özge Özkaya
Pregnancy has a favorable impact on the volume of deep infiltrating endometriosis lesions according to a study published in the scientific journal "PLoS One". This is the first study that demonstrates such a favorable impact of pregnancy on endometriosis lesion…
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The predictive factors for early spontaneous miscarriage in IVF/ICSI cycles
By Hale Goksever Celik
The most common presenting complaints of endometriosis are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Affected women demand therapy for these symptoms of endometriosis, notably fertility problems. The clinical pregnancy rate has increased up to 60% in assisted reproductive…
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The genetic mutations in uterine adenomyosis
By Hale Goksever Celik
Adenomyosis is defined as the localization of endometrial stromal and glandular cells in the myometrium. This disease is a reproductive-aged women disease, like endometriosis. Additionally, adenomyosis is frequently observed together with endometriosis and leiomyomas due to common histological features and…
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Adiposity, endometriosis type and severity
By Selma Oransay
Dr. Jiyoung from the division of Public Health, Department of Family and Preventive Medicine of the University of Utah, planned a prospective cross-sectional study to assess whether there is an inverse relationship between the adiposity and endometriosis. The results of…
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The role of acidic ribosomal protein P1 in Endometriosis
By Dr. Youngran Park
Endometriosis is an estrogen-dependent disorder. The disease develops and composed of the ectopic endometrial-like tissue which establishes primarily in the pelvic cavity. Previous findings clearly show that estrogen-related factors are critical for endometriosis development and progression. However, we do have…
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Endometriosis signaling: the role of IL-34
By Yu Yu
An increasing number of studies have suggested that the pathogenesis of endometriosis is mediated by cytokines, such as interleukin (IL)−17, which promoted the formation and progression of endometriosis by up-regulating angiogenesis and pro-inflammatory cytokines secretion. IL-34 is a newly described…
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Endometriosis and ovarian reserve
By Hale Goksever Celik
Endometriosis is most frequently encountered in reproductive-aged women. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of 25-40%. Although the exact mechanism explaining the association between…
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Surgery and the endometriosis associated-pain: A systematic review
By Selma Oransay
The surgical approach for pelvic pain-related to endometriosis depends on the stage and the type of the endometriotic lesion and ranging from ablation and the excision of the lesions to radical surgery as hysterectomy with removal of ovaries and presacral…
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MRI findings predicting the need for colorectal surgical treatment of deep infiltrating endometriosis
By Irem Onur
LAY SUMMARY: Brusic A. et al., a group of researchers from Australia, conducted a retrospective study to identify the features of deep infiltrating endometriosis on MRI which have an association with colorectal surgical bowel resection. They have recently published their…
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By Demet Candaş GreenIs deep infiltrating rectosigmoid endometriosis a progressive disease?
By Demet Candaş Green
This study by Netter at al., published in "Human Reproduction" in November 2019 aimed to assess the risk of progression of deep endometriotic nodules infiltrating the rectosigmoid and to evaluate the influence of continuous amenorrhoea (absence of menstruation) on the development…
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Risk of placenta previa is elevated in endometriotic women who underwent surgery.
By Selma Oransay
In the last decade concerns raised for surgical operations performed before pregnancies of endometriotic patients due to significantly increased risk of pregnancy complications such as placenta previa, preterm birth, hypertensive disorders of pregnancy, placental abruption, postpartum hemorrhage and small baby…
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Cloverleaf Sign: A new MRI sign for diagnosing DIE
By Selma Oransay
Magnetic resonance imaging provides accurate information for the staging of deeply infiltrating endometriosis, especially when the patient is virgin, obese or has limited transvaginal examinations due to pelvic pain. In this recently published study in Investive Radiology, Harma et al.…
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How Best to Assess Productivity at Work Among Women with Endometriosis?
By Özge Özkaya
The health-related productivity questionnaire (HRPQ) is a valid tool to evaluate patient-reported productivity at work and at home among women with endometriosis found a study by U.S. researchers. This finding is important because it shows that HRPQ can be used…
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The effect of endometriosis on implantation in women with endometriosis associated infertility
By Hale Goksever Celik
One of the most common clinical findings of women with endometriosis is fertility problems. Women with endometriosis often benefit from in vitro fertilization methods to get pregnant. However, whether there is a detrimental effect of endometriosis on in vitro fertilization outcomes…
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Serum anti-Müllerian hormone levels for predicting spontaneous pregnancy after endometriosis surgery
By Hale Goksever Celik
Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Although there are several medical and surgical therapeutic options, the most effective treatment modality has not yet been elucidated. The main…
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Is there any difference between endometriosis patients with or without obliterated cul-de-sac during laparoscopic hysterectomy?
By Hale Goksever Celik
Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. It is diagnosed in 10% to 15% of reproductive-aged women. Women with endometriosis demand therapy for the most common symptoms, which are…
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A new technique for laparoscopic management of ovarian endometriosis.
By Selma Oransay
To cause a minimal hazardous effect on ovarian reserve during laparoscopic surgery of endometriomas is always a great concern for clinicians. Shaltout et al. from Cairo University, Egypt, examined the effect of "Surgicel" on preventing the recurrence of endometriomas and…
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How to predict complications for endometriosis surgery?
By Timur Seckin
In a new study co-led by scientists at Sorbonne University, a nomogram is built to better inform patients about the risk of deep endometriosis surgery without bowel involvement. The findings have been published in the European Journal of Obstetrics &…
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Melatonin receptors and their role in endometrial cell proliferation
By Hale Goksever Celik
Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Despite extensive research, the exact pathophysiological mechanism and the optimal management of endometriosis still remains unclear. Management of endometriosis should aim to relieve pain,…
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The accuracy of "lower endoscopic ultrasound" for the preoperative diagnosis of rectosigmoid endometriosis
By Hale Goksever Celik
Endometriosis affects reproductive-aged women most frequently with a prevalence of 5% to 15%. If the endometriotic lesions involve the bowel especially sigmoid colon and rectum, this subtype of endometriosis is named as "bowel" or "rectosigmoid" endometriosis. Rectosigmoid endometriosis is encountered in…
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Which Diagnosis Technique is Better?
By Özge Özkaya
Transvaginal ultrasound provides a more accurate localization of vaginal and recto-vaginal endometriosis compared to magnetic resonance imaging (MRI) according to a study published in the International Journal of Gynecology & Obstetrics. However, MRI has better accuracy in detecting bladder endometriosis…
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Early Developmental Gene May Play a Role in Endometriosis
By Özge Özkaya
An early developmental gene called twist may encourage the connective tissue cells of the lining of the uterus to change from being epithelial to being mesenchymal, so-called epithelial to mesenchymal transition (EMT). Mesenchymal cells play important roles in biological processes…
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MRI or TVS for accurate diagnosis of rectosigmoid endometriosis?
By Demet Candaş Green
Rectosigmoid endometriosis (RE) is seen in about 90% of patients with bowel endometriosis. Rectosigmoid is the region between the rectum and the sigmoid colon, which is a region easily accessed and assessed by two most common noninvasive imaging modalities –…
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Surgical treatment of deeply infiltrating endometriosis in tertiary treatment centers
By Demet Candaş Green
In the present study, data from patients who were surgically treated for deep infiltrating endometriosis (DIE) in a tertiary referral unit, the Avicenna Centre for Endometriosis and Minimally Invasive Gynecology (ACEMIG, Tehran, Iran), were examined for rates of intraoperative and…
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The genetic predisposition to endometriosis
By Hale Goksever Celik
Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. Although endometrium is a non-malignant disease, its symptoms can range from mild to severe due to the inflammation that ectopic endometrial tissue forms around itself. The exact etiopathogenetic mechanism…
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The postoperative functional outcomes of deep infiltrating endometriosis
By Hale Goksever Celik
Rectosigmoid endometriosis is defined as the infiltration of the bowel wall with the endometrial-like glands and stroma, reaching at least the muscular layer. The most commonly involved sites are the rectum and sigmoid colon. For the management of deep infiltrating…
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A new trial to reduce the failure of IVF/ICS protocols in severe endometriosis
By Selma Oransay
Kong et al., from the first affiliated hospital of Zhengzhou University, China, recently published this single-blinded, a multicentered and randomized controlled study in the Journal of Reproductive Health, with the aim to find a safer and more effective ovulation induction regimen for patients with…
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The coexistence deep infiltrating endometriosis and fibromyalgia
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The main symptoms of endometriosis which are dysmenorrhea, dyspareunia, and chronic pelvic pain impair the quality of life of these women. This disease may…
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Can early-life exposures affect endometriosis development later in life?
By Demet Candaş Green
Endometriosis is a complex disease with possible multifactor contributors. So far, inflammatory, immunogenic, genetic, and environmental factors have all been associated with endometriosis. In addition, it is possible that different types of endometriosis lesions – peritoneal, ovarian, and deep infiltrating…
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Menstrual blood-derived stem cells
By Selma Oransay
Chen et al. from the Center of Diagnosis and Treatment of İnfectious Disease, Zhejiang University, China penned this recent review in the Journal of Stem Cell Research Therapy which is presenting the clinical potential of MenSCs (Menstrual blood-derived stem cells). …
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The appearance of postoperative endometriosis by imaging methods
By Hale Goksever Celik
Endometriosis is a chronic gynecological disease mostly encountered in reproductive-aged women. Endometriosis can occur in three different entities: peritoneal, ovarian and deep endometriosis. Golden standard diagnosis is made by histopathological examination of surgical material after laparoscopic surgery in women with…
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Study Sheds Light on the Molecular Mechanism of Endometriosis Development
By Özge Özkaya
A protein called transforming growth factor-beta1 (TGF-B1) enhances the capacity of endometriotic cells or cells that make up the lining of the uterus to migrate, invade, and colonize other areas in the body. This is according to a study published…
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Which comes first in endometriosis management: In vitro fertilization or surgery?
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence is found to be 7%–10%, but among infertile women, it increases up to 50%. Early diagnosis and personalized management are important to…
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The association between the development of endometriosis and dietary habits
By Hale Goksever Celik
Endometriosis is a chronic disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence is found to be approximately 10% in the general population. Endometriosis is associated with infertility, pelvic pain, and increased…
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Additional research in understanding the causative link between Notch signaling and endometriosis
By Nasuhi Engin Aydin
Dustin M. Brown and associates from the University of Arkansas for Medical Sciences published their unique complex molecular research in the Journal of the Endocrine Society. This study group previously showed that decreased expression of the progesterone receptor (PGR) resulted from…
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Somatic mutations in iatrogenic endometriosis.
By Selma Oransay
Lac and al., from the Department of Molecular Oncology in BC Cancer Research Center, Vancouver, Canada, planned a retrospective and multinational research to investigate the prevalence of somatic cancer-driver mutations in incisional endometriosis and recently published in the "Journal of Human Reproduction". Their…
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Surgical techniques for rectosigmoid endometriosis, and functional outcomes
By Hale Goksever Celik
Rectosigmoid endometriosis is defined as the infiltration of bowel wall with the endometrial-like glands and stroma, reaching at least the muscular layer. Rectosigmoid endometriosis is encountered in approximately 8-12% of patients with a diagnosis of endometriosis. The most commonly involved…
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Conservative Surgery May Be Sufficient to Halt the Development of Deep Endometriosis
By Özge Özkaya
Deep endometriosis develops as a result of collective cell migration and nerve recruitment from surrounding organs, suggests a study published in the scientific journal Fertility and Sterility. Collective cell migration is the biological process whereby a group of cells moves…
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Is the mystery for progression of endometriosis hiding out in abnormally located endometrial cells?
By Selma Oransay
This prospective study was conducted by Hapangama et al. in Research İnstute of the University of Liverpool, UK, and the results have recently published in the Journal of Human Reproduction. The authors hypothesized that abnormally located endometrial basalis-like (SSEA1/nSOX9+)cells could be contributing to…
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The role of circulating microRNA's in Endometriosis
By Dr. Youngran Park
Endometriosis is an estrogen-dependent disorder. This disease affects approximately 10% of reproductive-aged women and 20% to 50% of infertile women. Steroidogenic factor 1 (SF-1) is an essential transcriptional regulator coordinately regulating multiple genes involved in estrogen biosynthesis. SF-1 is known…
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By Murat OsmanLipophilic Statins inhibit growth and invasiveness of human endometrial cells
By Murat Osman
Endometriosis is a disease process whereby cells of the endometrium grow and invade structures outside of the uterus. Through recent research, it has been seen that endometriotic foci in women with endometriosis exhibit an altered phenotype that contributes to its…
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Pelvic pain, congenital genital tract anomalies and endometriosis
By Hale Goksever Celik
Any failure during development and differentiation of female genital tract results in congenital tract anomalies. The origin of the hymen is the union of the caudal portion of the paramesonephric ducts and the urogenital sinus. It functions as a mechanical…
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Further Results From the FEELING Study Published
By Özge Özkaya
Some women are more likely to develop deep infiltrating endometriosis according to the further analysis of the results of the FEELING study. These are women who: are married, are older, have siblings, have had a prior pregnancy, or for whom…
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Anti-proliferative and anti-inflammatory effects of "Quercetin" on endometriosis
By Dr. Youngran Park
Quercetin is a major flavonol that is mainly derived from capers and involves a daily consumption of approximately 25–50 mg through various vegetables. In recent studies, Quercetin is reported as a functional compound in obesity, diabetes and cardiovascular diseases. This compound…
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The pain and its severity in deeply infiltrating endometriosis patients
By Selma Oransay
Liang et al. from the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Sun Yat-sen University, China, recently published an interesting paper in the Journal of Pain Research, a prospective study to reveal the relationship between neurogenesis and other potential…
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Four cases of endometrioid borderline ovarian tumour: case reports and literature review
By Nasuhi Engin Aydin
Physicians from Kyoto University Graduate School of Medicine, Kyoto, Japan, report four cases of ovarian EBTs and a review literature in a recently published manuscript at British Medical Journal, case reports. Endometrioid borderline tumors (EBTs) of the ovary are uncommon…
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The diagnosis and management of endometriosis in Korea
By Selma Oransay
The Korean Society of Endometriosis has scrutinized the present published literature of endometriosis in the domestic and international platform to provide new guidelines and the clinical management of the disease. The study was recently published in the journal "Obstetrics and Gynecology…
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Can MRI be used to detect anterior pelvic endometriotic lesions?
By Hale Goksever Celik
Deep infiltrating endometriosis is the most severe manifestation of endometriosis. It is defined as the infiltration of ectopic endometrial tissue under the peritoneum, pelvic structures, and the organ walls such as the uterosacral ligaments, colon, vagina, bladder, ureter, rectovaginal septum,…
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Does deep infiltrating endometriosis affect sexual activity?
By Dr. Youngran Park
Endometriosis is one of the most common gynecological diseases in women of reproductive age, and pelvic pain and infertility are the most frequent complications. There are three different type of endometriosis lesions; superficial lesions, deep lesions, and ovarian cysts. In…
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Programmed cell death 4 suppresses endometriosis by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway
By Dr. Youngran Park
Endometriosis is a kind of benign disease but shares many similar features with cancers, such as abnormal cell migration, invasion, and unrestrained growth. It has been known that some genes are expressed differentially in eutopic endometrium of EM patients compared…
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Anatomic distribution of endometriosis
By Irem Onur
In the study of Audebert et al. which has been published in the journal European Journal of Obstetrics and Gynecology, the anatomic distribution of endometriosis, the rate of deep infiltrating endometriosis during the various study periods, laterality of endometriosis, pelvic…
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Non-assisted reproductive technology treatment: Is it effective in infertile patients with advanced endometriosis?
By Hale Goksever Celik
The marriage and childbearing ages delay due to the life-style changes in developed countries. As a result, advanced age becomes a major concern in infertility treatments which consist of non-ART and ART modalities. Non-ART treatments include mild ovarian stimulation together…
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PROPOFOL: a new combat for endometriosis?
By Selma Oransay
Feng et al, from the Department of Gynecology Weifang Medical University Hospital, Shandong, China, recently published their prospective experimental research in the journal Experimental and Therapeutic Medicine. Propofol, a rapid and short-term anesthetic substance, recently has been shown to prevent cancer through inhibiting…
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Parametrial endometriosis: A harder form of endometriosis
By Hale Goksever Celik
Deep infiltrating endometriosis is the most severe manifestation of endometriosis, affecting 20% of all patients with endometriosis. It is defined as the infiltration of ectopic endometrial tissue under the peritoneum, pelvic structures, and the organ walls such as the uterosacral…
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Will I Have Complications After Endometriosis Surgery?
By Özge Özkaya
The rate of complications after surgery to treat deep infiltrating endometriosis is low, confirmed a study by researchers in Germany. It is important to know whether major or minor complications following surgery are likely to develop and what the outcome…
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Laparoscopic surgery of endometriosis through three compartments
By Selma Oransay
This case study which is published in the J. of Minimally İnvasive Gynecology is the video demonstration of Collin et al who performed the laparoscopic operation of their patient in Gynecologic Surgery Department of Strasburg Hospital University, France. 37 years old…
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Kidney Hormone Potential Treatment for Endometriosis?
By Özge Özkaya
Erythropoietin, a hormone produced by the kidneys to promote the production of red blood cells could be a promising candidate for the treatment of endometriosis. This is according to a study published in the Journal Of The Turkish-German Gynecological Association by…
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Transvaginal ultrasound for "rectosigmoid endometriosis" diagnosis: Is bowel preparation necessary?
By Hale Goksever Celik
Rectosigmoid endometriosis is a severe form of deep endometriosis. Women having rectosigmoid endometriosis present with pain and several intestinal complains such as constipation, diarrhea, intestinal cramping, abdominal bloating, feeling of incomplete evacuation, the passage of mucus and rectal bleeding during…
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Reduced pain and increased fertiliy rates after surgery for colorectal endometriosis
By Selma Oransay
This prospective cohort study which recently published in AOGS by Hudelist et al. from Oslo University, Norway is about their one hundred thirty-four laparoscopic operations of DIE cases performed between 2011 and 2016, in a tertiary center in Oslo. The…
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IVF Is the Best Option to Become Pregnant for Women with Severe Endometriosis, or Is It Not?
By Özge Özkaya
Treating rectal endometriosis with surgery seems to increase the chance of a woman conceiving, with most pregnancies occurring naturally. This is according to a study published in the medical journal Human Reproduction. The optimal treatment for women with severe endometriosis…
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Endometrioma and endometriosis
By Irem Onur
Exacoustos C. et al. published an article titled “The isolated ovarian endometrioma: a history between myth and reality” in the Journal of Minimally Invasive Gynecology in 2018. They aimed to examine the association between ovarian endometriomas detectable at the transvaginal ultrasound…
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How to evaluate ureteral endometriosis : A review of the literature
By Selma Oransay
In this recently published review of the literature, Barra et al. from Genova, Italy intend to provide a useful tool to guide physicians in the management of deep infiltrating endometriosis. Authors elected 67 abstracts from Pubmed and Medline in accordance with PRISMA…
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Endometriosis in adolescents
By Irem Onur
Dr. Mama S. T. from Cooper University Hospital, Camden, New Jersey, USA, recently has published his review on advances in the management of endometriosis in the adolescent in the journal “Current Opinion Obstetrics and Gynecology”. In adolescence, there is a…
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A Better Way to Diagnose Endometriosis?
By Özge Özkaya
Three proteins found in the blood and endometrial tissues could be used to determine the stage of endometriosis and the severity of painful periods according to a study published in the journal Current Medical Science. Evaluating the levels of these…
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The vaginal delivery rate of singleton term pregnancies still remains the same after total deep infiltrating endometrosis excisions
By Selma Oransay
This recently published report in the Journal of Fertility Sterility is planned as a matched case-control study, by Nirgianakanis et al. from the University of Bern, Switzerland. Authors claimed their study is the first because previous studies on pregnancy outcome after laparoscopic…
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By Kasthuri NairGnRH Analogues Not Beneficial For Superovulation and Intrauterine Insemination
By Kasthuri Nair
Bansal et al, a group of authors from the All India Institute of Medical Sciences, recently published a paper titled “The Role of GnRH Analogues in Improving Outcome in Women Undergoing Superovulation and Intrauterine Insemination after Surgical Correction of Mild…
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Fluorescence Guided Surgery: a New Technique to Treat Deep Infiltrating Endometriosis
By Özge Özkaya
Fluorescence-guided surgery could help differentiate recto-vaginal deep infiltrating endometriosis nodules (RVDIEN) from healthy rectal tissue and remove them successfully without perforating the rectum, according to a study published in the scientific journal Surgical Innovation. The method could offer a better,…
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Could the Sleep Hormone Treat Endometriosis?
By Özge Özkaya
Melatonin blocks cell proliferation, invasion, and migration in both normal and endometriotic epithelial cells, according to a study published in the scientific journal Reproductive Biology and Endocrinology. Melatonin could, therefore, be a potential treatment for endometriosis The formation and progression…
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N-acetyl cysteine, alpha lipoic acid and bromelain improved endometriosis-associated pelvic pain
By Yu Yu
Oxidative stress has been implicated in many processes that lead to the development and progression of endometriosis. Typically, women with endometriosis have to endure pelvic pain which negatively impacts their quality of life. Pelvic pain can be chronic and related…
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Endometriosis Development: Pathogenesis and genomics
By Selma Oransay
In this review recently published in the International Journal of Molecular Sciences, Baranow et al from Saint Petersburg, Russia, hypothesize the existence of an endometriosis development genetic program (EMDP) that governs the origin of endometrium stem cells programmed for endometriosis; their transition…
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Altered Immunity in Endometriosis
By Yu Yu
In recent years, there has been increased attention on the role of immune system in endometriosis development. Normally, immune reactions are supposed to destroy endometrial cells seeding in the peritoneal cavity. Nonetheless, in endometriosis, these cells are able to evade,…
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Deep Infiltrating Endometriosis Impairs Sexual Function
By Kasthuri Nair
Lima et al., a group of scientists from Hospital do Servidor Público Estadual in Brazil, recently published an article entitled “Female Sexual Function in Women with Suspected Deep Infiltrating Endometriosis” in Revista Brasileira De Ginecologia E Obstetricia. The paper analyzed…
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Endometrial stem cells and Endometriosis
By Dr. Youngran Park
Human endometrium is a cyclically proliferative tissue, and this monthly regeneration is likely mediated by endometrial stem (or progenitor) cells.The upper functional layer of the endometrium breaks down and is shed into the uterine cavity during menstruation. Re-epithelialization and repair…
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Recurrence of Deep Infiltrating Endometriosis
By Yu Yu
There are mainly three types of endometriotic lesions. These are ovarian endometriosis, superficial peritoneal endometriosis, and deep infiltrating endometriosis (DIE). The latter is often described as a lesion with greater than 5 mm invasion of the peritoneal surface. DIE lesions…
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Blood vessels formation in endometriosis
By Yu Yu
The endometrium undergoes dynamic changes during the menstrual cycle. Estrogen-driven angiogenesis is associated with the proliferative phase, and progesterone-driven vascular maturation occurs in the secretory phase. Hence, it is reasonable that the vascularization of endometriosis is also under complex regulation…
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Can Getting Pregnant Make my Pain Go Away?
By Özge Özkaya
The association between pregnancy and symptoms of endometriosis are controversial and strongly biased, and there is no evidence suggesting that pregnancy reduces the size and number of endometriotic lesions, according to a study published in the journal Human Reproduction Update.…
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Laparoscopic Bowel Resection Can Be Beneficial Rectosigmoid Endometriosis
By Kasthuri Nair
Riiskjær et al. recently published a paper titled “Pelvic Pain and Quality of Life Before and After Laparoscopic Bowel Resection for Rectosigmoid Endometriosis: A Prospective, Observational Study” in Diseases of the Colon & Rectum. This paper focuses on the effects…
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The Use of Resveratrol as an Adjuvant Treatment of Pain in Endometriosis
By Dr. Youngran Park
Endometriosis is considered a predominantly estrogen-dependent disease, and therefore hormonal suppression might be an attractive medical approach to treat this disease and its symptoms. Resveratrol is a natural phytoestrogen synthesized by plants and has known to have side effects such…
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MRI Best at Detecting Intestinal Deep Infiltrating Endometriosis
By Özge Özkaya
Magnetic resonance imaging (MRI) seems to be a better method in identifying deep infiltrating endometriosis in the intestine compared to two-dimensional ultrasonography (2DUS), found a study by researchers in Italy and Spain. However, this does not seem to be the…
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Changes in Complement Proteins Affect Infertility in Women with Endometriosis
By Kasthuri Nair
Palomino et al. recently published a paper titled “The endometria of women with endometriosis exhibit dysfunctional expression of complement regulatory proteins during the mid-secretory phase” in the Journal of Reproductive Immunology where they look at the expression of CRPs during the menstrual cycle of…
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Can grapefruits and oranges be used for treatment of endometriosis?
By Demet Candaş Green
Naringenin is a plant-based nutrient found abundantly in grapefruits and oranges with well-known anti-cancer, anti-inflammatory, and anti-oxidant properties. Previous studies showed that naringenin could modify the estrogen receptor signaling, suggesting a role for naringenin in endometriosis. The current study performed…
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How Could Doctors Reduce Risk of Complications Following Rectal Endometriosis Surgery?
By Özge Özkaya
Introducing a temporary opening, known as a stoma, in the abdomen of patients that are operated for rectal endometriosis to collect waste products could reduce the risk of complications such as anastomotic leakage. This is according to a study by…
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EFA Medical Conference 2017: “Literature Review, Our Data, and Case Presentations” by Dr. Karli Goldstein
By Özge Özkaya
Dr. Karli Goldstein started her presentation with a brief literature review on the relationship between endometriosis and breast cancer. She focused on a research article by Dr. Spandidos and colleagues, which was the first epidemiological study that examined the possible…
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A key cytokine in endometriosis can be targeted for endometriosis treatment
By Demet Candaş Green
Immune system dysfunction has been implicated in the development of endometriosis. One study showed that 95% of cells found in the peritoneal fluid of women with endometriosis are macrophages with impaired phagocytic function, which are unable to eat away unwanted…
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Revisiting the wandering womb: Oxytocin in endometriosis and bipolar disorder
By Dr. Youngran Park
Despite a Hysteria (from Greek hysterikos, meaning ‘of the womb’) was dismissed as causing mental illness, recent evidence links oxytocin with diverse and correlated psychological and physical symptoms and conditions that more frequently affect women than men. This article proposes…
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Biomarkers as a Diagnostic Tool
By Kasthuri Nair
Ahn, Singh and Tayade discuss the difficulties and delay in diagnosing Endometriosis in their paper titled “Biomarkers in endometriosis: challenges and opportunities.” Thus far research has identified a multitude of potential biomarkers that are found in various parts of the…
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Role of immune cells in endometriosis
By Demet Candaş Green
Immune cells have essential functions in the body such as detection and clearance of abnormal cells and debris. One of the possible mechanisms for the development of endometriosis is proposed to be the impaired function of immune system cells in…
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Estrogen Receptor-β in Women’s Health
By Yu Yu
Since the discovery of estrogen receptor (ER), there has been a vast number of studies regarding its functions in cellular and physiological processes. The identification of estrogen receptor-β (ERβ), a second receptor, resulted in a much more complex understanding of the…
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An update of estrogen receptors on human disease
By Yu Yu
Estrogens and its receptors influence numerous human physiological processes. Two estrogen receptors exist, including estrogen receptor α (ERα) and ERβ. Hence, it is essential to elucidate the functions of these receptors in healthy and diseased states. This is particularly important…
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Endometriosis May Be Causing Women to Become More Sensitive to Pain
By Özge Özkaya
Inflammation caused by endometriosis may be changing the way a woman perceives pain, found a new study published in the journal Regional Anesthesia and Pain Medicine. According to Dr. Neziri Alban at University Hospital of Bern, Switzerland and the co-authors…
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The Role of Natural Killer Cells in the Development of Endometriosis Unravelled
By Özge Özkaya
Specialized immune cells called natural killer cells found in the peritoneal fluid of women with severe endometriosis may facilitate the development of the disease, according to a study published in the American Journal of Reproductive Immunology. This finding could help…
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Roles of Progesterone in Endometrial Cancer, Endometriosis, Uterine Fibroids, and Breast Cancer
By Yu Yu
Progesterone is an important hormone, which together with estrogen prepares the women endometrium and breast tissue for pregnancy. The roles of progesterone in human tissues and diseases can be difficult to decipher. While there is a strong evidence for the…
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Endometriosis Does Not Increase Overall Risk of Breast Cancer, Study Finds
By Özge Özkaya
Endometriosis is not associated with the overall risk of breast cancer, according to a study published in the journal Obstetrics & Gynecology. The condition may, however, be significantly associated with an increased risk of breast tumors that express estrogen receptors (ER)…
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Is there a risk of developing breast cancer for women with endometriosis?
By Murat Osman
Understanding the interplay between the development of breast cancer and the presence of endometriosis and vice versa is complex since many risk factors including hormone or genetic variations and medical treatments have a role in each disease process. Thus, parsing…
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Association between blood inflammatory markers and the risk of endometriosis
By Yu Yu
Previous studies have suggested that aberrant immunologic and inflammatory responses may play a role in the pathogenesis of endometriosis. Peritoneal fluid collected from endometriosis contains elevated immune cells that may enhance the survival of endometriosis by secreting growth factors and…
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A Two-Wave Molecular Mechanism for Endometriosis Disease Progression
By Kasthuri Nair
Kobayashi et al. recently published a review paper in Molecular Medicine Reports titled “Pathogenesis of endometriosis: The role of initial infection and subsequent sterile inflammation,” which discusses at length the role of non-specific bacterial infection and sterile inflammation in the…
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CCL19/CCR7 Interaction can Casue Characteristic Cell Proliferation
By Kasthuri Nair
In their paper published in the American Journal of Reproductive Immunology titled “CCL19/CCR7 contributes to the pathogenesis of endometriosis via PI3K/Akt pathway by regulating the proliferation and invasion of ESCs,” Diao et al. hope to elucidate one of the mechanisms…
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Fetal Membranes Abnormalities in Pregnant Women with DIE
By Kasthuri Nair
Marcellin, Méhats, and Gogusev formulated a study where they analyzed alterations in the fetal membranes (FM) of women suffering from severe endometriosis. Their paper titled “Histopathological Alterations in Fetal Membranes of Women With Endometriosis” was recently published in the Reproductive…
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Best Time for IVF Between 7 and 25 Months Post Surgery Study Suggests
By Özge Özkaya
The more severe endometriosis is, the lower the success rate of IVF, according to a new study published in the Journal of Minimally Invasive Gynecology. However, the presence of endometriosis as such does not seem to affect the outcome of…
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By Vishaan NurseyArcyriaflavin A Decreases Endometriosis Cell Viability and Proliferation
By Vishaan Nursey
The purpose of this research topic was to determine whether Arcyriaflavin A could serve as a potential new therapeutic option for those suffering from Endometriosis. Arcyriaflavin A is a Cyclin D1 inhibitor. Cyclin D1 regulates the cell cycle by interacting…
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The Potential Molecular Mechanisms that Drive Endometriosis Progression
By Kasthuri Nair
Endometriosis is a mysterious disease in that the exact mechanism that causes the illness is still at large. Yang et al. recently published a paper in the European Review for Medical and Pharmacological Sciences that hopes to elucidate the molecular…
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Factors that Impact IVF-ICSI Outcomes of live birth
By Kasthuri Nair
Endometriosis affects women in their reproductive years, which often makes it difficult for women with this disease to reproduce. A paper published in the Journal of Assisted Reproduction and Genetics by Roux et al. from Marseille, France, addressed this issue…
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Women with Deep Infiltrating Endometriosis Have a Higher Risk of Appendix Involvement
By Özge Özkaya
Women with deep-infiltrating endometriosis, a form of endometriosis that invades the abdominal and pelvic cavity, have an increased risk of developing endometriosis of the appendix. It is therefore important to check women with deep infiltrating endometriosis for appendix involvement during…
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Ovarian Endometriomas vs Deep Infiltrating Endometriosis
By Yu Yu
Ovarian endometrioma (OMA) and deep infiltrating endometriosis (DIE) have been described as two disease entities, although they are both characterized by endometrial tissue located outside the uterus. As OMA and DIE look different histologically, it is puzzling what cause their…
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An Antagonist for Endometriosis Disease Progression: LINC00261
By Kasthuri Nair
The molecular mechanisms surrounding endometriosis remain elusive to this day. Sha et al. from Wenzhou Medical University, China, reported that LINC00261, a long non-coding RNA, may play a substantial role in inhibiting the pathogenesis of this painful illness. Their paper…
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The Role of IL-35 in the Pathogenesis of Endometriosis
By Kasthuri Nair
The molecular mechanism that drives endometriosis remains elusive to this day. Zhang et al believe that interleukin 35 (IL-35) plays a role in the pathogenesis of the disease. Their recent publication in Reproductive Sciences titled “Upregulation of Interleukin 35 in…
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Bowel Involvement in Deep Infiltrating Endometriosis
By Özge Özkaya
Cleansing the colon before an ultrasound makes it easier to detect rectal nodules of deep infiltrating endometriosis, found a study published in the Journal of Minimally Invasive Gynecology. Cleansing the colon before a surgery is called bowel preparation and is…
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Ping-Chong-Jiang-Ni Formula: A Natural Treatment
By Kasthuri Nair
In the world of modern medicine, natural and herbal remedies are often under utilized. Liang et al. recently published an article in Evidence-Based Complementary and Alternative Medicine where they explored the benefits of using a Chinese Herbal Medicine to treat…
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Abdominal Wall Endometriosis
By Kasthuri Nair
Endometriosis can present itself in many places including within the pelvic organs, the more common manifestation, and outside of the pelvic organs, often referred to as extrapelvic endometriosis. One form of extrapelvic endometriosis is Abdominal Wall Endometriosis (AWE). Yela, Trigo,…
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The Benefits of Vaginal Administration of Drugs
By Kasthuri Nair
There are numerous methods of drug administration used by healthcare providers today. Buggio and colleagues suggest the vagina as another avenue for delivery. They recently published a paper titled "Per vaginam" topical use of hormonal drugs in women with symptomatic…
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How ERα is regulated in endometriosis?
By Yu Yu
Endometriosis pathogenesis is largely influenced by estrogen. Ectopic endometrium has altered expression of ERα compared to the eutopic endometrium. It is unclear what biological processes regulate such alteration. The article by Toderow et al. in Archives of Gynecology and Obstetrics…
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Robotic Assisted Laparoscopy Not Better Than Standard Laparoscopy
By Özge Özkaya
Robotic-assisted laparoscopy (RAL) does not seem to offer any benefits over standard laparoscopy, according to a study published in the scientific journal Reproductive Biomedicine Online. According to the authors of the study more research is needed to investigate the role…
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Deep Infiltrating Endometriosis, Surgery and Fertility
By Kasthuri Nair
Carneiro, Costa, and Ávila recently published an article in a scientific journal named Reproduction, titled “To operate or not to operate on women with deep infiltrating endometriosis (DIE) before in vitro fertilization (IVF),” that explored the relationship between DIE and infertility.…
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By Asli Bahadirli TalbottA potential indicator of invasive endometriosis.
By Asli Bahadirli Talbott
Furuya & Masuda et al., in their recent article that will be published in Acta Obstet Gynecol Scand, report that the protein encoded by ZEB1 gene (Zinc finger E-box-Binding homeobox) is a potential indicator of invasive endometriosis. ZEB1 is a transcription factor that has been implicated…
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How Resveratrol is effective in endometriosis?
By Asli Bahadirli Talbott
In their review paper, Mohammadi and Arablou recommend using Resveratrol, a plant-derived compound, for the treatment of endometriosis. Resveratrol is abundant in nature and can be found in many different plant species, fungi, berries, peanuts, legumes, and grasses; however, grapes…
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How rats can help improve colon endometriosis treatment in humans
By Demet Candaş Green
Colorectal endometriosis forms about 3–37% of all deep infiltrating endometriosis (DIE) cases. DIE is a highly invasive type of endometriosis, occurs when ovarian endometriomas overgrow and rupture, releasing their contents into the abdominal and pelvic cavity, resulting in the formation…
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By Laura ArdighieriUnexpected "cancer-related" mutations in "non-cancerous" endometriosis: Do they predict aggressiveness?
By Laura Ardighieri
A study supported by Endometriosis Foundation of America, reported by scientists from Johns Hopkins Medicine (Baltimore, USA) and the University of British Columbia (Vancouver, Canada) have identified the molecular alterations of deep infiltrating endometriosis trough a wide exome sequencing (protein-coding genetic alphabet…
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