Cancer, is that a real risk?

Cancer, is that a real risk? By Yu Yu

Endometriosis is non-malignant but shares some similar features with cancer, such as the occurrence of local and distant foci, the ability to resist cell death, and the ability to invade other tissues, causing damage to the organs. Endometriosis also generates…

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Endometriosis and possible cardiovascular outcomes

Endometriosis and possible cardiovascular outcomes By Selma Oransay

A retrospective population-based cohort study from the Institute of Applied Health Research, University of Birmingham, Birmingham, the UK, investigated the long-term cardiovascular outcomes of women with endometriosis. The study included 279,759 women in total, 20,1% (>56.000) were patients with surgically…

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Environmental to occupational exposure, and possible risk factors for endometriosis.

Environmental to occupational exposure, and possible risk factors for endometriosis. By Selma Oransay

Many objects in daily use are made of plasticizing agents. Studies suggest that chronic exposure to these agents are toxic to reproductive organs and cause metabolic disorders. For example, diethyl phthalate is still in use in cosmetic products.  Caporossi et…

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Endometriosis and the risk of Systemic lupus Erythematosus: A report from Taiwan

Endometriosis and the risk of Systemic lupus Erythematosus: A report from Taiwan By Selma Oransay

Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage that affects mostly women, with an M:F ratio of 1:9. Recent evidence has also shown that endometriosis is…

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The improvement of fertility rate and symptoms of superficial endometriosis following laparoscopic peritoneal stripping

The improvement of fertility rate and symptoms of superficial endometriosis following laparoscopic peritoneal stripping By Selma Oransay

Pain, in the form of diverse entities, including dyspareunia, dysuria, dyschezia, is the main symptom of endometriosis patients. The severity of pain is independent of the extent and the location of the disease, and generally causes a negative impact on…

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What is the cause of Dienogest-resistance in patients with endometrioma?

 What is the cause of Dienogest-resistance in patients with endometrioma? By Selma Oransay

Endometriosis may cause infertility in women, leading to adhesions in the pelvis, besides affecting the ovaries. Clinicians concern about the child-bearing desire of their patients when treating them surgically or with hormonal therapy. Dienogest (DNG) is a kind of progestin,…

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Insoluble Dilemma of Adenomyosis: Diagnosis, Management, and Treatment  - Errico Zupi, MD

Insoluble Dilemma of Adenomyosis: Diagnosis, Management, and Treatment  - Errico Zupi, MD By Selma Oransay

The prevalence of adenomyosis has been reported to range from 1% to 70% in different studies. This large range can be explained by the lack of standard diagnostic criteria by imaging modalities or pathological analyses. Sixty-five% of the women with adenomyosis…

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Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD

Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD By Selma Oransay

The removal of endometrioma may affect ovarian reserve because healthy follicles near endometrioma could also be excised during this procedure. Another concern about the ovarian reserve is that it may be already low before the surgery. Anti Mullerian Hormone (AMH)…

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Comparison of diagnostic accuracy of imaging modalities for the deep infiltrating endometriosis

Comparison of diagnostic accuracy of imaging modalities for the deep infiltrating endometriosis By Selma Oransay

The treatment of deeply infiltrated endometriosis (DIE) is usually personalized and the potential success for the available therapeutical options is dependent on early and accurate diagnosis. Laparoscopy is the gold standard for the diagnosis of DIE. Other non-invasive diagnostic methods…

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The peculiarity of adolescent endometriosis

The peculiarity of adolescent endometriosis By Selma Oransay

Recent studies showed the prevalence of endometriosis in adolescents with chronic cyclic or acyclic pelvic pain is about 60-70%. Moreover, all stages of endometriosis, including deeply infiltrating endometriosis can be found in this population. Gubbels et al. from the Department…

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Endometriosis-related obstetrical complications and their outcome

Endometriosis-related obstetrical complications and their outcome By Selma Oransay

Borisova et al. from the Department of Gynecology and Obstetrics of Peoples' Friendship University, Moskow, Russia, and her colleagues from the Center of Perinatal and Reproductive Medicine of University Perugia, Italy, recently published a review of the literature data about…

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Predictors of voiding dysfunction after surgery for deep endometriosis

Predictors of voiding dysfunction after surgery for deep endometriosis By Selma Oransay

While surgery for deep endometriosis provides relief and improves the quality of life in symptomatic patients for whom medical therapy has limited effect, it may also create postoperative lower urinary tract dysfunction. Moreover, postoperative voiding dysfunction could affect the quality…

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Benefits of Nerve-Sparing Hysterectomy

Benefits of Nerve-Sparing Hysterectomy By Selma Oransay

The retroperitoneal spread of endometriosis or cancer may involve pelvic autonomic nerves situated on the lateral aspects of uterosacral ligaments, vesicouterine ligaments, and medial aspects of parametria. During the conventional open hysterectomy operations, nerve-sparing excision is very difficult, simply because pelvic autonomic nerves…

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Hysterectomy as a choise of chronic pelvic pain relief in endometriotic women.

Hysterectomy as a choise of chronic pelvic pain relief in endometriotic women. By Selma Oransay

Sandstrom et al. from the Department of Obstetrics and Gynecology of Umea University, Sweden, found a significant and long-lasting reduction in pain symptoms after hysterectomy among women with confirmed endometriosis and recently published their results in "BJOG". The authors performed…

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Diagnosis and treatment algorithm for endometriosis

Diagnosis and treatment algorithm for endometriosis By Selma Oransay

Endometriosis is a chronic and progressive disease that affects 25-30% of women between 25-35years, clinicians commonly experience during their gynecologic practice. However, the diagnosis is still late or sometimes incorrect, and this creates severe health problems and worse outcomes. A…

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Surgical approach to rectovaginal endometriosis.

Surgical approach to rectovaginal endometriosis. By Selma Oransay

Recto-vaginal endometriosis incidence is estimated at 3.8%-37% among women with endometriosis and when it exists it's a part of deeply infiltrated endometriosis, thus advance stage endometriosis. Raimondo et al. from the Department of Obstetrics and Gynecology of the University of…

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Fertility conservation in women with endometriosis

Fertility conservation in women with endometriosis By Selma Oransay

Endometriosis affects 10-15% of women in their reproductive period and almost half of them may need Assisted Reproductive techniques to conceive. Moreover, increased malignancy risk is threatening the women with severe endometriosis in addition to their decreased ovarian reserve. Due…

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The Relationship Between Dyspareunia and Infertility in Endometriosis

The Relationship Between Dyspareunia and Infertility in Endometriosis By Selma Oransay

Wahl et al. from the Center of Pelvic Pain and Endometriosis British Columbia Women's Hospital, Vancouver, Canada studied with endometriotic patients suffering from dyspareunia who were referred to their center and built a cross-sectional study to investigate the relations between…

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Diaphragmatic endometriosis

Diaphragmatic endometriosis By Selma Oransay

Diaphragmatic endometriosis is a rare clinical condition that may show signs and symptoms like chest pain, right upper quadrant abdominal pain, shoulder pain, pleuritic pain, hemothorax, pneumothorax, hemoptysis, and thoracic endometriosis syndrome while the major part of the patients is…

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Adiposity, endometriosis type and severity

Adiposity, endometriosis type and severity By Selma Oransay

Dr. Jiyoung from the division of Public Health, Department of Family and Preventive Medicine of the University of Utah, planned a prospective cross-sectional study to assess whether there is an inverse relationship between the adiposity and endometriosis. The results of…

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Treatment choices for abdominal wall endometriosis

Treatment choices for abdominal wall endometriosis By Selma Oransay

Welch et.al, from the Department of  Radiology, Mayo Clinic, Rochester, worked with his gynecologist colleagues to underline the current treatment algorithm of abdominal wall endometriosis in Mayo Clinic. Their experience results recently published in the journal "Abdominal Radiology". Abdominal wall…

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How to design patient-centered interventions to meet the needs of endometriosis patients

How to design patient-centered interventions to meet the needs of endometriosis patients By Selma Oransay

The treatment of endometriosis is not perfect and necessitates the development of patient-oriented care initiatives. On this basis, patient-related transparent information should be the priority for researchers to find out a way for targeted interventions. Steele et al. from Australia and…

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Surgery and the endometriosis associated-pain: A systematic review

Surgery and the endometriosis associated-pain: A systematic review By Selma Oransay

The surgical approach for pelvic pain-related to endometriosis depends on the stage and the type of the endometriotic lesion and ranging from ablation and the excision of the lesions to radical surgery as hysterectomy with removal of ovaries and presacral…

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Cloverleaf Sign: A new MRI sign for diagnosing DIE

Cloverleaf Sign: A new MRI sign for diagnosing DIE By Selma Oransay

Magnetic resonance imaging provides accurate information for the staging of deeply infiltrating endometriosis, especially when the patient is virgin, obese or has limited transvaginal examinations due to pelvic pain. In this recently published study in Investive Radiology, Harma et al.…

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Increased obstetrical complications after ART therapy in endometriosis patients.

Increased obstetrical complications after ART therapy in endometriosis patients. By Selma Oransay

To examine the impact of endometriosis and adenomyosis on ART therapy, Harada et al. from the Department of Obstetrics and Gynecology of Tottori University, Japan, planned a prospective cohort study and published their results recently in PLoS One.  The study…

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Consquences of endometriosis in menopausal period.

Consquences of endometriosis in menopausal period. By Selma Oransay

Marie-Scemama et al. from Foch Hospital, Suresnes, France, referred to endometriosis and menopause which is an actual cruising topic and recently published it in the journal named "Hormone Molecular Biology and Clinical Investigation". Endometriosis a well-known estrogen-dependent disease has three…

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A new technique for laparoscopic management of ovarian endometriosis.

 A new technique for laparoscopic management of ovarian endometriosis. By Selma Oransay

To cause a minimal hazardous effect on ovarian reserve during laparoscopic surgery of endometriomas is always a great concern for clinicians. Shaltout et al. from Cairo University, Egypt, examined the effect of "Surgicel" on preventing the recurrence of endometriomas and…

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Endometriosis and the quality of life

Endometriosis and the quality of life By Selma Oransay

Recent developments of technics and improvement of skill in the laparoscopic field increased the courage of clinicians to attempt early and multiple diagnostic operations on endometriotic patients. Vanuccini et al. from NEUROFARBA, University of Florence, Florence, Italy recently published their…

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Adolescent dysmenorrhea and future endometriosis

Adolescent dysmenorrhea and future endometriosis By Selma Oransay

Dysmenorrhoea is typically classified as primary, or secondary due to underlying pathologies like fibroids, endometriosis, adenomyosis or uterine anomalies. Generally, long-term dysmenorrhea is present in endometriotic patient's anamnesis, but until recently, the research to clarify this connection remained retrospective. Knox et…

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What happens to women with endometriosis after menopause?

What happens to women with endometriosis after menopause? By Selma Oransay

Endometriosis affects women in their reproductive period of life, with expected regression of lesions in the postmenopausal period. Literature about postmenopausal endometriosis assessing the prevalence, pathogenesis, and treatment is limited. As 2-5 % of postmenopausal women are affected by this uncommon condition, developing stress…

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How to Classify Endometriosis for a better and effective evaluation

How to Classify Endometriosis for a better and effective evaluation By Selma Oransay

Endometriosis affects 10% of women in their reproductive period and causes infertility around 40% of women who have the disease. Peritoneal fluid may be one of the factors to facilitate the spread of endometriosis to ovaries, peritoneum and other deep…

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Analogous pathways of peritoneal tumor wound healing and endometriosis.

Analogous pathways of  peritoneal tumor wound healing and endometriosis. By Selma Oransay

Endometriosis, diagnosed around 10-15% of women population in their reproductive period, is a chronically progressive inflammatory disease to cause peritoneal lesions while spreading into the abdominal cavity. The pathophysiology of the adhesions between the peritoneum and pelvic organs can be…

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The reason for lower BMI and less body fat in women with endometriosis.

The reason for lower BMI  and less body fat in women with endometriosis. By Selma Oransay

Zolbin et al. from the Department of Obstetrics and Gynecology of Yale School of Medicine, New Haven, USA, recently published the results of their prospective controlled research on adipocyte alterations in endometriosis, in the journal "Reproductive Biology and Endocrinology". Endometriosis can…

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Menstrual blood-derived stem cells

Menstrual blood-derived stem cells By Selma Oransay

Chen et al.  from the Center of Diagnosis and Treatment of İnfectious Disease, Zhejiang University, China penned this recent review in the Journal of Stem Cell Research Therapy which is presenting the clinical potential of MenSCs (Menstrual blood-derived stem cells). …

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Estrogen Receptor Signaling and Endometriosis-Associated Ovarian Cancer

Estrogen Receptor Signaling and Endometriosis-Associated Ovarian Cancer By Selma Oransay

Andersen et al. published a prospective cohort study in the Journal of Hormones and Cancer to enlighten the estrogen signaling pathway during the transition from endometriosis to endometriosis-associated ovarian cancer. Given the shared pathway of endometriosis and ovarian cancer as…

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Can we prevent the progression of endometriosis?

Can we prevent the progression of endometriosis? By Selma Oransay

Torres-Reveron et al. from the University of Texas, USA, planned this prospective laboratory research on female rats to assay the reduce on the progression of endometriosis and recently published the results in PloS One. At first,  endometriosis was induced in female rats…

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Somatic mutations in iatrogenic endometriosis.

Somatic mutations in iatrogenic endometriosis. By Selma Oransay

Lac and al., from the Department of Molecular Oncology in BC Cancer Research Center, Vancouver, Canada, planned a retrospective and multinational research to investigate the prevalence of somatic cancer-driver mutations in incisional endometriosis and recently published in the "Journal of Human Reproduction". Their…

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Is the mystery for progression of endometriosis hiding out in abnormally located endometrial cells?

Is the mystery for  progression of endometriosis hiding out in abnormally located endometrial cells? By Selma Oransay

This prospective study was conducted by Hapangama et al. in Research İnstute of the University of Liverpool, UK, and the results have recently published in the Journal of Human Reproduction. The authors hypothesized that abnormally located endometrial basalis-like (SSEA1/nSOX9+)cells could be contributing to…

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Laparoscopic surgery of endometriosis through three compartments

Laparoscopic surgery of endometriosis through three compartments By Selma Oransay

This case study which is published in the J. of Minimally İnvasive Gynecology is the video demonstration of Collin et al who performed the laparoscopic operation of their patient in Gynecologic Surgery Department of Strasburg Hospital University, France. 37 years old…

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Is there a new hope for the prevention of endometriotic invasions?

Is there a new hope for the prevention of endometriotic invasions? By Selma Oransay

This research which recently published in Biomed Research International is performed by Xiaomei et al. from Obst/Gyn, Pathology and Genetic departments of three hospitals in Changsha, CHINA. The authors planned a prospective and controlled biochemical study to specify the role…

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The effects of MK2206 and chloroquine combination therapy on endometriosis.

The effects of MK2206 and chloroquine combination therapy on endometriosis. By Dr. Youngran Park

Endometriosis affects approximately 10% of women of reproductive age. A high recurrence rate after medical treatment with or without surgery is a significant clinical problem for patients with endometriosis. Establishment of a complete cure for patients with endometriosis awaits new…

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The role of the B lymphocytes in endometriosis: A systematic review

The role of the B lymphocytes in endometriosis: A systematic review By Murat Osman

Insight into the role of an inflammatory response in endometriosis has sparked further study into the role of different immune cells and their causal relationship to the pathogenesis of endometriosis. Several recent studies have found an association between aberrant immune…

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Special considerations for the evaluation of Endometriosis on MRI

Special considerations for the evaluation of Endometriosis on MRI By Murat Osman

Pelvic endometriosis may involve either superficial peritoneal or ovarian tissues or may spread to the organs and ligaments of the pelvis in what is known as deeply infiltrating endometriosis (DIE). According to the size and location of these lesions, patients…

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Retinoic Acid Signaling Involved in Endometrial Decidualization

Retinoic Acid Signaling Involved in Endometrial Decidualization By Murat Osman

Decidualization occurs in the eutopic endometrium during the luteal phase and is controlled by signaling pathways such as cyclic adenosine monophosphate (cAMP) and progesterone. Researchers from the Northwestern University School of Medicine reported in their recent paper entitled "Altered Retinoid…

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