Endometriosis: Beyond the naked eye visibility

Endometriosis: Beyond the naked eye visibility By Bahar Yuksel

The gold standard method for endometriosis diagnosis is histopathologic evaluation of the resected lesions. The study conducted by Sara-Michelle Gratton et al. in Canada evaluated the possible effect of developed laparoscopic skills and equipment on the endometriosis diagnosis, and whether…

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A new "survey-based" endometriosis diagnostic tool

A new By Bahar Yuksel

Endometriosis is a disease that is diagnosed years after its appearance which causes life quality impairment to patients. It is crucial for the patient to find out the probability of the presence of endometriosis, for applying to healthcare providers before…

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A rare complication of  endometriosis

A rare complication of  endometriosis By Selma Oransay

Morales et al. from the Monterrey School of Medicine, Mexico, reported a case of bowel intussusception in a woman with severe endometriosis to draw attention to this very rare endometriosis complication. The case is a 27 years old young female…

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Ovarian Cancer Survival in the presence of Endometriosis

Ovarian Cancer Survival in the presence of Endometriosis By Özge Özkaya

Women with ovarian cancer and histologically proven endometriosis have longer overall survival compared to those with ovarian cancer but no endometriosis, found a study published in the American Journal of Obstetrics & Gynecology.  “[…] Women diagnosed as having ovarian cancer…

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The added value of transvaginal hydro-laparoscopy for infertile women

The added value of transvaginal hydro-laparoscopy for infertile women By Selma Oransay

The added value of invasive diagnostic laparoscopy has been questioned, postponed by the increased usage of ultrasonography for the evaluation of infertile patients. Gordts et al. from Life Expert Center, Leuven, Belgium have been working on an alternative way called "transvaginal hydro-laparoscopy" to…

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The role of physical examination and interview in Endometriosis Diagnosis

The role of physical examination and interview in Endometriosis Diagnosis By Bahar Yuksel

Today we know that the most accurate diagnosis of endometriosis necessitates surgery and histopathological examination of the excised lesions. However, many women are misdiagnosed due to various symptoms of endometriosis which mystify gastrointestinal, urinary, and musculoskeletal diseases. Nawrocka-Rutkowska and colleagues…

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The incidence and prevalence of endometriosis in a United States population-based study .

The incidence and prevalence  of endometriosis in a United States population-based study . By Selma Oransay

To define the accurate incidence and prevalence estimates of endometriosis among nonselected cohorts in the USA, Christ et al. from the Departments of Obstetrics and Gynecology of the University of Washington, Seattle, planned a retrospective cohort study using the electronic KPWA…

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A scoping review proposal for the diagnostic and treatment delay of endometriosis

A scoping review proposal for the diagnostic and treatment delay of endometriosis By Hale Goksever Celik

Women with endometriosis suffer from pain for a prolonged time due to diagnostic and treatment delay which is the most challenging aspect of endometriosis. Cromeens et al, from the USA, published a review entitled “Timing, delays, and pathways to the…

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Exploring a bonafide biomarker to predict endometriosis

Exploring a bonafide biomarker to predict endometriosis By Eylül GÜN

Endometriosis is a complex disease affecting many women in the reproductive age group. As it is important to figure out the mechanisms responsible for the disease, it is also crucial to identify biomarkers that can be used in the diagnosis…

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Promising therapeutic results in experimental endometriosis model

Promising therapeutic results in experimental endometriosis model By Nasuhi Engin Aydin

Tiziana Genovese and associates from Italian academic centers reported their pioneering findings in an experimental model of endometriosis administering an anti-tumor agent and glucocorticoid combination, published in the scientific periodical “International Journal of Molecular Sciences”. Endometriosis is a worldwide common disease…

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Is the presence of nerve fibers in the endometrium associated with endometriosis?

Is the presence of nerve fibers in the endometrium associated with endometriosis? By Eylül GÜN

Endometriosis is a common disease in reproductive women and diagnostic imaging have a limited role in its diagnosis. The gold standard diagnostic method remains to be the histopathological examination of the tissue obtained via laparoscopy. One of its most common…

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Analyses of the main classification systems of endometriosis in terms of utrasound, MRI and surgery

Analyses of the main classification systems of endometriosis in terms of utrasound, MRI and surgery By Selma Oransay

Several classifications made by gynecologists, image readers, and radiologists lead to confusion while describing the situation and estimating the progress of endometriosis. Daniela Fischerova team from the Charles University of Prague, Czech Republic, analyzed the main classifications of endometriosis in three…

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The Severity of Pain Does not Predict Endometriosis or its Stage, Study Confirms

The Severity of Pain Does not Predict Endometriosis or its Stage, Study Confirms By Özge Özkaya

The intensity of pain a woman experiences could predict whether or not she would undergo laparoscopic surgery. However, it could not predict whether she has endometriosis or in case she did, the severity of her disease. This is according to…

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A pictorial overview of abdominal wall endometriosis

A pictorial overview of abdominal wall endometriosis  By Hale Goksever Celik

Abdominal wall endometriosis is the most frequent location of extrapelvic endometriosis, and defined as the presence of ectopic endometrial tissue between the peritoneum and the skin through the abdominal wall. Although obstetric or gynecologic surgical history is indispensable for the…

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Myeloid-Derived Suppressor Cells are gaining importance in endometriosis

Myeloid-Derived Suppressor Cells are gaining importance in endometriosis By Nasuhi Engin Aydin

Dr. Wertel and associates from Polish academic centers published their sentimental review paper on the role of "Myeloid-Derived Suppressor Cells" in human diseases, in a recent issue of  Cells. Endometriosis, the most common gynecological disease affecting about 10% of women globally,…

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The association of chronic endometritis, endometriosis and tubal infertility

The association of chronic endometritis, endometriosis and tubal infertility By Selma Oransay

Holzer et al. from the Department of Gynecologic Endocrinology and Reproductive Medicine of  Medical University of Vienna, Austria, set up apilot prospective cohort study to evaluate the relationship between chronic endometritis, infertility and endometriosis. The results of the study were recently…

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Improvement of the quality of life after surgery for deep infiltrating endometriosis.

Improvement of the quality of life after surgery for deep infiltrating endometriosis. By Selma Oransay

Deeply infiltrating endometriosis is the most severe form among the endometriosis types. The required laparoscopic approach is the appropriate excision of endometriotic foci from pelvis, by consideration of failure and side effects of the medical treatments. The specialist endometriosis centers…

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Endometriosis of the Diaphragm, What do the Doctors Know About it?

Endometriosis of the Diaphragm, What do the Doctors Know About it? By Özge Özkaya

The median time between the first consultation with a primary care physician and receiving a diagnosis of endometriosis of the diaphragm is two years according to a study by U.K. researchers. In the worse case, it took 23 years for…

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Time for noninvasive serum markers for endometriosis diagnosis

Time for noninvasive serum markers for endometriosis diagnosis By Nasuhi Engin Aydin

Dr. Onur Guralp and associates from Germany and Turkey published their results on serum markers predicting endometriosis in the "Journal of Obstetrics and Gynaecology".   Still, in 21st-century medicine, doctors can not diagnose endometriosis using biochemical serum markers. Proposed serum markers…

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Endometriosis, Fatigue and Productivity

 Endometriosis, Fatigue and Productivity By Ellen Tumimbang

Fatigue is one of the prominent and distressing symptoms of endometriosis-associated with insomnia, depression, pain, occupational stress, and reduced health-related quality of life. Endometriosis-related fatigue causes significant impairments in workplace productivity and daily activities of women with endometriosis. Loss of…

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Endometriosis: Less is better. How to improve the integration between surgical and medical therapy - Errico Zupi, MD

Endometriosis: Less is better. How to improve the integration between surgical and medical therapy - Errico Zupi, MD By Özge Özkaya

In this presentation, Dr. Errico Zupi, Associate Professor in the Department of Obstetrics and Gynecology at the University of Rome talks about the importance of an integrative approach comprising of both medical and surgical interventions to treat endometriosis.  "The first…

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Endometriosis and chronic opioid use

Endometriosis and chronic opioid use By Selma Oransay

The members of the American College of Obstetricians and Gynecologists have declared that gynecologists prescribe opioids after laparoscopic hysterectomy, or for relieving endometriosis pain, although guidelines are not available for when or how to use opioids for the treatment of endometriosis-associated…

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Adolescent endometriosis: Diagnostic clues?

Adolescent endometriosis: Diagnostic clues? By Irem Onur

The rates of dysmenorrhea, dyspareunia, and heavy menstrual bleeding in adolescents showing endometriosis signs on ultrasound are significantly higher compared to those without. This is according to a retrospective observational study recently published in the journal "Fertility and Sterility". The…

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Comparison of diagnostic accuracy of imaging modalities for the deep infiltrating endometriosis

Comparison of diagnostic accuracy of imaging modalities for the deep infiltrating endometriosis By Selma Oransay

The treatment of deeply infiltrated endometriosis (DIE) is usually personalized and the potential success for the available therapeutical options is dependent on early and accurate diagnosis. Laparoscopy is the gold standard for the diagnosis of DIE. Other non-invasive diagnostic methods…

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Combination of noninvasive biomarkers in the identification of endometriosis

Combination of noninvasive biomarkers in the identification of endometriosis By Timur Seckin

The combined measurement of urine enolase, serum CA125, and CA19-9 may be an accurate test for the prediction and detection of endometriosis. This is according to a study published in the journal BioMedical Research International. The gold standard for the…

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A new Marker to Detect Endometriosis and Its Severity?

A new Marker to Detect Endometriosis and Its Severity? By Özge Özkaya

Macrophage migration inhibitory factor (MIF) could be a novel marker that could help diagnose endometriosis as well as to detect its severity. This is according to a new study by researchers in Egypt, published in the scientific journal "BMC Women’s Health".…

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Diagnosis and treatment of endometriosis in adolescents

Diagnosis and treatment of endometriosis in adolescents By Irem Onur

The belief that dysmenorrhea, the primary symptom of endometriosis, in adolescents is an inevitable condition seen in menstruation as well as unwillingness to perform diagnostic laparoscopy may cause the delay of diagnosis of endometriosis. This is according to a recent…

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Is Endometriosis More Common Among Women of Certain Race/Ethnicity?

Is Endometriosis More Common Among Women of Certain Race/Ethnicity? By Özge Özkaya

Race/ethnicity seems to have an influence on the prevalence of endometriosis with black women appearing to be less likely to be diagnosed with the disease compared to white women. However, other factors such as access and response to treatment may…

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Endometriosis Diagnosis in White, Black, and Asian Women

Endometriosis Diagnosis in White, Black, and Asian Women By Özge Özkaya

In a commentary published in the "International Journal of Obstetrics and Gynaecology", Drs. Farland and Horne talk about a study by researchers in Canada and the Philippines, which found that black women are less likely, and Asian women are more likely to…

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Case-control study to develop a questionnaire for early diagnosis of endometriosis

Case-control study to develop a questionnaire for early diagnosis of endometriosis By Nadire Duru

Endometriosis, which affects 5–10% of women of reproductive age, is a chronic gynecological disease characterized by the presence of endometrial glands and stroma outside the uterus, associated with several discomforts such as pelvic pain, menstrual disorders, and infertility. Ultrasound evaluation…

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Postmenopausal endometriosis: Is it a rare phenomenon?

Postmenopausal endometriosis: Is it a rare phenomenon? By Hale Goksever Celik

Endometriosis, the estrogen-dependent disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity, is generally diagnosed in the reproductive-aged women. However, recent literature proved that this disease can also be observed in the premenopausal and…

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A Routine Pelvic Ultrasound Examination Should Include an Evaluation for Endometriosis

A Routine Pelvic Ultrasound Examination Should Include an Evaluation for Endometriosis By Özge Özkaya

Routine pelvic ultrasound examination should be extended beyond the uterus and ovaries into the posterior and anterior pelvic compartments, according to Australian doctors.  With such examinations, deep infiltrating endometriosis nodules can be searched, say the authors, allowing women to be…

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All aspects of endometriosis reviewed with focus on modern management

All aspects of endometriosis reviewed with focus on modern management By Nasuhi Engin Aydin

Dr. Chapron and associates from academic centers in France published in Nature Review Endocrinology, a comprehensive review on endometriosis. The article is inclusive of all aspects of endometriosis but especially focuses on the management of the disease with its contemporary status.  Having a…

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Clinical Evaluation of Endometriosis-Associated Pain

Clinical Evaluation of Endometriosis-Associated Pain By Nadire Duru

Endometriosis has a noteworthy impact on the quality of life of the patients diagnosed with it since it is associated with unpleasant conditions such as endometriosis-associated pain. The diagnosis of endometriosis is not always straightforward because of the varying symptoms…

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Primary care physicians have a crucial role in the early diagnosis of endometriosis

Primary care physicians have a crucial role in the early diagnosis of endometriosis By Nasuhi Engin Aydin

Dr. Verket and associates from the University of Oslo, Norway, published their cross-sectional anonymous postal questionnaire study in "BMJ open". Diagnosing endometriosis is difficult because dysmenorrhea, dyspareunia, and infertility are also common among other diseases. The most accurate and reliable diagnosis…

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Integrated bioinformatic analysis for endometriosis diagnosis

Integrated bioinformatic analysis for endometriosis diagnosis By Nadire Duru

Endometriosis is considered as a non-malignant disease, but it is associated with several unfavorable conditions including non‑menstrual pelvic pain and infertility. Surgical resection and hormone suppression are common means of treatments; however, several side-effects and the recurrence are not preventable.…

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Endometriosis and Women’s Tendency Towards Blood Clotting

Endometriosis and Women’s Tendency Towards Blood Clotting By Özge Özkaya

Women with ovarian endometriomas have an abnormally increased tendency toward blood clotting, study shows. Researchers think that this is due to the inflammatory nature of endometriosis. So abnormal coagulation parameters could be used to diagnose endometriosis, however, more detailed studies…

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A review of endometriosis in adolescent girls and young women

A review of endometriosis in adolescent girls and young women By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease which is commonly diagnosed in reproductive-aged women. On the other hand, this disease can develop earlier in life due to different etiopathogenetic mechanisms. Especially adolescents who experienced neonatal uterine bleeding are under the risk for…

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Circulating Endometrial Cells

Circulating Endometrial Cells By Yu Yu

Endometriosis is difficult to diagnose because of non-specific symptoms. Currently, there is no biomarker that allows for non-invasive diagnosis of the condition.  Surgical laparoscopy remains the standard for diagnosis. Circulating endometrial cells (CECs) is the lymphovascular spread of endometrial cells.…

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Transvaginal Ultrasound of Endometriosis

Transvaginal Ultrasound of Endometriosis By Murat Osman

A recent manuscript published by Collins et al. from the Department of Radiology at Penn State Hershey Medical Center aims to review the transvaginal ultrasound (TVUS) evaluation of endometriosis and offer a protocol that is dedicated to the thorough evaluation…

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New Protein for Endometriosis Diagnosis

New Protein for Endometriosis Diagnosis By Özge Özkaya

A protein called TIMP3 (tissue inhibitor of metalloproteinase-3) could be used for the diagnosis and prognosis (likely course) of endometriosis.  The early diagnosis of endometriosis is of paramount importance because it can help to diagnosis and thus initiate the right…

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Endometriosis and the quality of life

Endometriosis and the quality of life By Selma Oransay

Recent developments of technics and improvement of skill in the laparoscopic field increased the courage of clinicians to attempt early and multiple diagnostic operations on endometriotic patients. Vanuccini et al. from NEUROFARBA, University of Florence, Florence, Italy recently published their…

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How Long Does it Take to Be Diagnosed with Endometriosis?

How Long Does it Take to Be Diagnosed with Endometriosis? By Özge Özkaya

It takes a median of eight years to reach a diagnosis of endometriosis from when the symptoms of the condition first appear confirmed a new British study. Interestingly, it seems that the earlier the symptoms appear, the later the disease…

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Adolescent dysmenorrhea and future endometriosis

Adolescent dysmenorrhea and future endometriosis By Selma Oransay

Dysmenorrhoea is typically classified as primary, or secondary due to underlying pathologies like fibroids, endometriosis, adenomyosis or uterine anomalies. Generally, long-term dysmenorrhea is present in endometriotic patient's anamnesis, but until recently, the research to clarify this connection remained retrospective. Knox et…

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Which Diagnosis Technique is Better?

Which Diagnosis Technique is Better? By Özge Özkaya

Transvaginal ultrasound provides a more accurate localization of vaginal and recto-vaginal endometriosis compared to magnetic resonance imaging (MRI) according to a study published in the International Journal of Gynecology & Obstetrics. However, MRI has better accuracy in detecting bladder endometriosis…

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MRI or TVS for accurate diagnosis of rectosigmoid endometriosis?

MRI or TVS for accurate diagnosis of rectosigmoid endometriosis? By Demet Candaş Green

Rectosigmoid endometriosis (RE) is seen in about 90% of patients with bowel endometriosis. Rectosigmoid is the region between the rectum and the sigmoid colon, which is a region easily accessed and assessed by two most common noninvasive imaging modalities –…

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Seven Hormonal Biomarkers for Diagnosing Endometriosis

Seven Hormonal Biomarkers for Diagnosing Endometriosis By Dr. Youngran Park

Endometriosis is an inflammatory condition characterized by implantation and invasive growth of endometrial tissue outside the uterine cavity. Although it is benign, endometriosis has cancer-like features, a mutation profile similar to that of ovarian cancer, and increased ovarian cancer risk.…

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Proposed algorithm for a clinical diagnosis of endometriosis.

Proposed algorithm for a clinical diagnosis of endometriosis. By Selma Oransay

This recently published article in the American Journal of Obstetrics and Gynecology is about the challenge of diagnosing endometriosis, its impact on women's daily life and authored by Agarwal et al. from The University of California, San Diego, CA, USA. Authors called attention…

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Adenomyosis (endometriosis interna): an enigmatic disease that has to be discovered yet

Adenomyosis (endometriosis interna): an enigmatic disease that has to be discovered yet By Nasuhi Engin Aydin

Scientists, Drs. Vannuccini and Petraglia from Italy have published an open access comprehensive review of Adenomyosis in "F1000Research" in March 2019 issue. Adenomyosis is a uterine disorder in which endometrial glands and stroma are pathologically demonstrated within the myometrium, i.e.…

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Immunologic Disorder in the Progression of Endometriosis

Immunologic Disorder in the Progression of Endometriosis By Dr. Youngran Park

Endometriosis becomes increasingly a health-social problem. However, definite diagnostic biomarkers and more effective treatments for endometriosis are still missing to this day.  Many researchers focus on the peritoneal microenvironment of patients with endometriosis, especially the immunological microenvironment. Recently, Jørgensen et…

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PAX8 immunohistochemistry in the diagnosis of Extragenital Endometriosis

PAX8 immunohistochemistry in the diagnosis of Extragenital Endometriosis By Serdar Balci

This study is performed by Arakawa T et al., from the University of Tokyo, Tokyo, Japan, and the results are published in Reproductive Sciences. Endometriosis is seen in many organs including peritoneum, ovaries, bowel, bladder, and even lung. Histopathologic diagnosis may…

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Bowel endometriosis: What you need to know

Bowel endometriosis: What you need to know By Demet Candaş Green

When the endometrial tissue infiltrates the intestinal walls and reaches inside the intestines, this condition is called "bowel endometriosis". It is estimated that between 3.8% and 37% of women with endometriosis are affected by bowel endometriosis. The endometriosis lesions infiltrating…

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Development of Less Invasive Diagnostic Tests for Endometriosis Through Proteomics

Development of Less Invasive Diagnostic Tests for Endometriosis Through Proteomics By Murat Osman

Proteomics is a field which utilizes various methods to carry out large-scale studies of proteins. Due to the inherent nature of the field, proteomics focuses on the identification, localization, and functional analysis of the protein make-up of a given type…

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Factors related to delay in endometriosis diagnosis

Factors related to delay in endometriosis diagnosis By Nasuhi Engin Aydin

Dr. Moniek van der Zanden, a gynecologist from Netherlands has recently made a nationwide survey on the impact of key recommendations of the European Society of Human Reproduction and Embryology (ESHRE) guidelines on endometriosis and aimed to assess factors influencing diagnostic delay of…

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A Brief Review of Endometriosis

A Brief Review of Endometriosis By Timur Seckin

Endometriosis is a common disease among women of reproductive age. It is more frequently seen among women without prior pregnancies, women with a family history of endometriosis, and women with abnormal menstrual periods. Peiris et al., researchers from the United…

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Endometriosis: A review on anatomic principles and the management

Endometriosis: A review on anatomic principles and the management By Irem Onur

In the study of Alimi et al. which has been published in the journal Cureus, various aspects of endometriosis such as the pathophysiology, the anatomy, the pain mechanism, the perineural spread theory, clinical manifestations, diagnosis, and imaging, infertility, unusual cases,…

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Preoperative Staging of Endometriosis: The Value of MRI After Dynamic Transvaginal Ultrasound

Preoperative Staging of Endometriosis: The Value of MRI After Dynamic Transvaginal Ultrasound By Irem Onur

Since endometriosis is a chronic and progressive disease, early diagnosis and proper staging are important for the patient and for the clinician to discuss and plan the required surgical procedures for treatment. Common diagnostic tools for pre-operative staging of deep…

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Fighting with endometriosis

Fighting with endometriosis By Irem Onur

Maduro M.R. reviewed three separate studies on potential new targets to successfully manage endometriosis in her recent paper titled “Novel Strategies to Fight Endometriosis” published in the journal Reproductive Sciences. In the autotransplantation rat model of Torres-Reveron et al., the…

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How to evaluate ureteral endometriosis : A review of the literature

How to evaluate ureteral endometriosis :  A review of the  literature By Selma Oransay

In this recently published review of the literature, Barra et al. from Genova, Italy intend to provide a useful tool to guide physicians in the management of deep infiltrating endometriosis. Authors elected 67 abstracts from Pubmed and Medline in accordance with PRISMA…

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A Better Way to Diagnose Endometriosis?

A Better Way to Diagnose Endometriosis? By Özge Özkaya

Three proteins found in the blood and endometrial tissues could be used to determine the stage of endometriosis and the severity of painful periods according to a study published in the journal Current Medical Science. Evaluating the levels of these…

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How are endometriosis patients managed clinically?

How are endometriosis patients managed clinically? By Irem Onur

This review paper by Falcone and Flyckt, entitled “Clinical Management of Endometriosis” published in the journal Obstetrics & Gynecology aims to summarize the current strategies for treating endometriosis patients with pain, pelvic dysfunction, and subfertility related to their disease. There are many…

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Detecting endometriosis using peripheral blood

Detecting endometriosis using peripheral blood By Yu Yu

Laparoscopic visualization of endometriotic lesions with histological confirmation is the gold standard for the diagnosis of endometriosis. However, this diagnostic procedure, due to the need for laparoscopy and variability of disease/symptoms, can have a major delay up to 8-10 years…

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Catching Endometriosis Early

Catching Endometriosis Early By Kasthuri Nair

Li et al., a group primarily from Sun Yat-sen University in the People’s Republic of China, recently published an article titled “Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages” in Reproductive Biology and Endocrinology. The…

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A Way to Better Diagnose Colorectal Endometriosis

A Way to Better Diagnose Colorectal Endometriosis By Özge Özkaya

Combining magnetic resonance imaging (MRI) with computed tomography-based virtual colonoscopy (CTC) can make the assessment of colorectal endometriosis more accurate. This is important because it can help doctors plan the surgery better and inform their patients. In order to evaluate…

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An Unusual Case "Free Floating Omental Endometrioma"

An Unusual Case By Kasthuri Nair

Capaccione et al. published an article in Radiology Case Reports titled “Massive endometrioma presenting with dyspnea and abdominal symptoms.” This publication is centered around a particularly unique case report of a woman who was ultimately diagnosed with endometriosis. The patient…

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The Past, Present, and Future of Diagnosing Endometriosis

The Past, Present, and Future of Diagnosing Endometriosis By Kasthuri Nair

This review titled “Endometriosis: Epidemiology, Diagnosis and Clinical Management” published in Current Obstetrics and Gynecology Reports examines the distribution and factors associated with endometriosis. The analysis by Parasar, Ozcan, and Terry also delineates potential biomarkers and risk factors that could…

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The Challenging Path to Diagnosis

The Challenging Path to Diagnosis By Kasthuri Nair

Kallia O. Wright, a professor at Illinois College, recently published her essay titled “You have Endometriosis”: Making Menstruation Related Pain Legitimate in a Biomedical World” in Health Communication. This essay delineates the author’s experience with endometriosis. The author started experiencing…

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Blood vessels formation in endometriosis

Blood vessels formation in endometriosis By Yu Yu

The endometrium undergoes dynamic changes during the menstrual cycle. Estrogen-driven angiogenesis is associated with the proliferative phase, and progesterone-driven vascular maturation occurs in the secretory phase. Hence, it is reasonable that the vascularization of endometriosis is also under complex regulation…

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Skin Endo Diagnosis

Skin Endo Diagnosis By Özge Özkaya

High-frequency ultrasound can be very useful for the early diagnosis of cutaneous endometriosis according to a study published in the journal Skin Research and Technology. The diagnostic tool could be used in patients who have unusual cyclical pain even before…

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Is the presence of endometriosis associated with a survival benefit in pure ovarian clear cell carcinoma?

Is the presence of endometriosis associated with a survival benefit in pure ovarian clear cell carcinoma? By Dr. Youngran Park

Ovarian clear cell carcinoma (OCCC) has been known to be associated with endometriosis for a long time. However, the impact of the presence of endometriosis around the tumor on the prognoses of women with OCCC is still controversial. To shed…

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Intestinal Endometriosis and Colorectal Cancer versus T4 Colorectal Cancer

Intestinal Endometriosis and Colorectal Cancer versus T4 Colorectal Cancer By Kasthuri Nair

Ishii et al. recently published a paper titled “Intestinal endometriosis combined with colorectal cancer: a case series” in the Journal of Medical Case Reports. This case report follows 7 Japanese women who have intestinal endometriosis and colorectal cancer. These women…

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Diagnostic and treatment guidelines for gastrointestinal and genitourinary endometriosis.

Diagnostic and treatment guidelines for gastrointestinal and genitourinary endometriosis. By Murat Osman

Endometriosis may affect the pelvic reproductive system, but it can also be found in non-reproductive organs such as the gastrointestinal and urinary tract. The article outlined below discusses the diagnosis and management of genitourinary and gastrointestinal endometriosis. Gastrointestinal endometriosis: The…

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MRI Best at Detecting Intestinal Deep Infiltrating Endometriosis

MRI Best at Detecting Intestinal Deep Infiltrating Endometriosis By Özge Özkaya

Magnetic resonance imaging (MRI) seems to be a better method in identifying deep infiltrating endometriosis in the intestine compared to two-dimensional ultrasonography (2DUS), found a study by researchers in Italy and Spain. However, this does not seem to be the…

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How good are the current guidelines on endometriosis? 

How good are the current guidelines on endometriosis?  By Dr. Youngran Park

The endometriosis was first described in 1860, yet the etiology and pathogenesis remain poorly understood. Treatment strategies vary significantly between disease severity and the symptoms of pain and/or subfertility. These challenges have resulted in multidirectional research, and the comparability of…

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Do Adolescents and Adults Experience Endometriosis Differently?

Do Adolescents and Adults Experience Endometriosis Differently? By Özge Özkaya

Symptoms of endometriosis seem to be the same between women surgically diagnosed during adolescence and those diagnosed as adults, according to a study published in the American Journal of Obstetrics and Gynecology. For both age groups, pelvic pain was severe,…

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Ectoenzymes as endometriosis biomarkers

Ectoenzymes as endometriosis biomarkers By Yu Yu

The diagnosis of endometriosis is often delayed by 7 to 11 years because of the lack of a non-invasive diagnostic test. The ovarian endometriomas occur in about 17%-44% of women with endometriosis and cysts which contain endometrial tissue and fluid…

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Endometriosis early pointers

Endometriosis early pointers By Yu Yu

Endometriosis can take a long time to diagnose, thus associated with prolonged symptoms of pain, subfertility and patient frustration/demoralization. It can be difficult to diagnose clinically because the symptoms are common and non-specific so that GP can misconceive them as…

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Urocortin 1 as a noninvasive diagnostic marker for endometriosis

Urocortin 1 as a noninvasive diagnostic marker for endometriosis By Demet Candaş Green

Urocortin 1 (Ucn1) is a neuropeptide secreted by epithelial cells of the endometrium. It promotes endometrial differentiation to help with embryo implantation. Endometriotic lesions were shown to be rich in Ucn1, suggesting a potential role for Ucn1 in the pathogenesis…

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Endometriosis Should be Diagnosed Timely and Properly

Endometriosis Should be Diagnosed Timely and Properly By Kasthuri Nair

The pain of endometriosis is often worsened by delayed diagnosis. The National Institute for Health Care and Excellence (NICE) recently published guidelines for the quick and accurate diagnosis of endometriosis. Jacqui Wise discusses these recommendations and their implications in her…

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Overview of NICE Endometriosis Guidelines

Overview of NICE Endometriosis Guidelines By Kasthuri Nair

In this article titled “Diagnosis and management of endometriosis: summary of NICE guidance,” Kuznetsov et al. talk through the recent endometriosis guidelines set forth by The National Institute for Health Care and Excellence (NICE). The BMJ publication hopes to elucidate…

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Endometriosis and Psychological Health: Butterflies from Deep Wounds

Endometriosis and Psychological Health: Butterflies from Deep Wounds By Kasthuri Nair

Endometriosis is a grueling disease in every sense of the word; however, most of the discussions center on the physical manifestations of the disease. Facchin et al. veer from the beaten path and examine the impact endometriosis have on a…

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Surgical treatment of colonic endometriosis

Surgical treatment of colonic endometriosis By Demet Candaş Green

In this study, the authors provide a brief report published in the journal "The American Surgeon" which retrospectively reviewed the therapy outcomes in eight consecutive patients who had a laparoscopic surgical intervention for deeply infiltrating endometriosis (DIE) at Anne Arundel Medical Center. The…

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Glycodelin and altered endometrial function in endometriosis

Glycodelin and altered endometrial function in endometriosis By Yu Yu

A laparoscopic examination is the only diagnostic tool for endometriosis to date. Since the procedure is invasive, there has been much effort by researchers to develop a biomarker for non-invasive diagnosis of endometriosis. To this end, there has been growing…

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"Kissing Round Ligaments" May Be a Sign of Bladder Endometriosis

By Özge Özkaya

Specific laparoscopic findings may help surgeons diagnose bladder endometriosis, a rare and often undiagnosed condition.  Bladder endometriosis is thought to affect only around one percent of patients with endometriosis. However, this could be an underestimation and many cases may go…

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Patient-completed or symptom-based screening tools for endometriosis: a scoping review.

Patient-completed or symptom-based screening tools for endometriosis: a scoping review. By Karime Kalil Machado

Endometriosis affects approximately 10% of women in reproductive age. Its clinical presentation is variable, and symptoms, such as chronic pelvic pain, may overlap with those of other benign conditions, making differential diagnosis challenging. Therefore, a patient-completed screening questionnaire could potentially…

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More than Four Years Pass Before Endometriosis is Diagnosed After Symptoms First Appear

More than Four Years Pass Before Endometriosis is Diagnosed After Symptoms First Appear By Özge Özkaya

The average time that passes between the onset of symptoms such as pelvic pain and the diagnosis of endometriosis is 4.4 years on average, according to a study conducted by researchers at the pharmaceutical company Abbvie and published in the…

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