The most influential adverse effects of endometriosis

The most influential adverse effects of endometriosis By Nasuhi Engin Aydin

Academicians from the Queen’s University, Ontario Canada led by Dr. Velez published their population-based cohort study related to pregnancy complications in a recent issue of the Journal of Obstetrics and Gynaecology Canada. This population-based cohort study analyzed the association between endometriosis and…

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Endometriosis Prevalence High Among Women With Unexplained Infertility

Endometriosis Prevalence High Among Women With Unexplained Infertility By Özge Özkaya

The prevalence of endometriosis and tubal abnormalities is still high among patients with unexplained infertility, according to a new study published in the scientific journal Reproductive BioMedicine Online.  “The high prevalence of endometriosis in this population is important for decision-making…

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Ovarian Endometrioma Does Not Affect Egg Quality, Study Suggests

Ovarian Endometrioma Does Not Affect Egg Quality, Study Suggests By Özge Özkaya

Ovarian endometrioma could decrease oocyte yield in patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), according to a new literature review and meta-analysis published in the scientific journal Reproductive BioMedicine Online. However, it does not seem to…

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Rare but clinically important diagnosis; Herlyn-Werner-Wunderlich syndrome

Rare but clinically important diagnosis; Herlyn-Werner-Wunderlich syndrome By Nasuhi Engin Aydin

The staff of the Department of Ultrasonography, Third Xiangya Hospital Central South University, Hunan, China have published their case series of the rare Herlyn-Werner-Wunderlich syndrome (HWWS) in a recent issue of Reproductive Sciences. HWWS, is a rare genital tract anomaly…

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Retrograde Menstruation Theory Through Müllerian Anomalies

Retrograde Menstruation Theory Through Müllerian Anomalies By Selma Oransay

The pathogenesis of endometriosis is still under debate. Sampson also described this condition as "developmentally misplaced endometrial tissue" in 1925.  To evaluate the theories of pathogenesis, Vercellini et al. from the Academic Center for Research on Adenomyosis and Endometriosis at…

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Study Sheds Light on Effect of Endometriosis and Infertility on Couples

Study Sheds Light on Effect of Endometriosis and Infertility on Couples By Özge Özkaya

Endometriosis and infertility are significantly associated with partnership and sexuality satisfaction, according to a new study published in the scientific journal Archives of Gynecology and Obstetrics. However, the large overlap between endometriosis and infertility underscores the fact that more research…

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Improving fertility in peritoneal endometriosis

Improving fertility in peritoneal endometriosis By Selma Oransay

Endometriosis is the most common gynecologic disease that affects 10-15% of women in their reproductive age. The causal relationship between endometriosis and infertility is not clear yet, but adhesions and anatomical distortions due to the progression of the disease are…

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The need for fertility preservation in women with endometriosis

The need for fertility preservation in women with endometriosis By Selma Oransay

A variety of pathologies such as adhesions, inflammation, modified pelvic anatomy, and altered ovarian reserve are among the causes of infertility in women with endometriosis. Additionally, these patients experience suboptimal outcomes characterized by reduced pregnancy rates when they undergo assisted…

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A concerning link between endometriosis and cardiovascular disease.

A concerning link between endometriosis and cardiovascular disease. By Selma Oransay

Endometriosis is a disease characterized by endometrial-like tissues outside the uterus, which causes inflammation, scarring, and adhesion formation. The pathologic process of forming those adhesions releases proinflammatory molecules, cytokines, and growth factors that may have systemic effects. Recent research, for…

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The location of adenomyosis, and recurrent abortion

The location of adenomyosis, and recurrent abortion By Selma Oransay

ESHRE defines repeated pregnancy loss (RPL) as the loss of pregnancies with two or more weeks of gestation. Adenomyosis is the presence of ectopic endometrium, in the myometrium. High-resolution transvaginal ultrasound and sonographic criteria can help to diagnose the disease…

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Do I Need Assisted Reproduction to Become Pregnant After Endometriosis Surgery?

Do I Need Assisted Reproduction to Become Pregnant After Endometriosis Surgery? By Özge Özkaya

Researchers from Argentina developed a decision tree that can help identify patients who might need assisted reproduction techniques to become pregnant following endometriosis surgery.  This way, the time between surgery and pregnancy could be minimized and the overall outcome may…

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Long-term Dienogest Treatment and the Chance of Conceiving With IVF

Long-term Dienogest Treatment and the Chance of Conceiving With IVF By Özge Özkaya

It is not clear whether long-term treatment with dienogest before in vitro fertilization (IVF) affects pregnancy and live birth rates in women with endometriosis, according to a new study published in the Journal of Obstetrics and Gynaecology Canada.  “Given limited…

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Early use of hormonal contraceptives and the probability of endometriosis diagnosis later in life

 Early use of hormonal contraceptives and the probability of endometriosis diagnosis later in life By Selma Oransay

Hormonal contraceptives are the first-line medical treatment of endometriosis. If an adolescent has chronic pelvic pain and is an "unresponder" to hormonal therapy, the likelihood of having an "endometriosis diagnosis" is higher. This sign should warn clinicians about endometriosis diagnosis…

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Psychological effect of endometriosis due to chronic pelvic pain

Psychological effect of endometriosis due to chronic pelvic pain By Hale Goksever Celik

The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, and chronic pelvic pain, all of which affect the quality of women’s lives. Early diagnosis and management are important as endometriosis impairs the quality of life of patients and creates a…

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Clinical awareness for endometriosis in infertility should be surged

Clinical awareness for endometriosis in infertility should be surged By Nasuhi Engin Aydin

A team of researchers from multiple centers including Stanford University and Swiss Federal Laboratories, led by Dr.Camran Nezhat have published their cross-sectional retrospective study on endometriosis and unexplained infertility association. This research paper appeared in a recent issue of the Journal…

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Fertility outcomes after discoid excision for colorectal endometriosis.

Fertility outcomes after discoid excision for colorectal endometriosis. By Selma Oransay

Colorectal endometriosis is one of the most severe forms of deep endometriosis, composing 85% of all bowel lesions. Radical treatment is segmental resection of the bowels, which can cause postoperative severe complications such as rectovaginal fistula and voiding dysfunctions that negatively…

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Spontaneous Conception After Deep Endometriosis Surgery

Spontaneous Conception After Deep Endometriosis Surgery By Selma Oransay

Deep endometriosis is a severe form of endometriosis where lesions invade deeper than 5 mm into subperitoneal space. Surgical management of the disease is a challenging task requiring a multi-disciplinary approach and significant expertise in the field. Anastomotic leaks, fistula,…

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Embryo Morphokinetics of Endometriotic Patients by Time Lapse Monitoring

Embryo Morphokinetics of Endometriotic Patients by Time Lapse Monitoring By Selma Oransay

Many studies showed adverse effects of endometriosis on oocyte quality due to increased apoptosis and dysregulation of molecular pathways related to the development and growth of granulosa cells resulting on developmental arrest in embryos of women with endometriosis. Time-lapse monitoring…

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A non-invasive test to determine the risk of endometriosis in women having chronic pelvic pain or unexplained infertility

A non-invasive test to determine the risk of endometriosis in women having chronic pelvic pain or unexplained infertility By Hale Goksever Celik

Women having endometriosis may suffer from chronic pelvic pain and/or infertility, both of which diminish the quality of life in these women. Minimalization of the time between the onset of symptoms and diagnosis is essential to improve patients’ lives. However,…

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Deep infiltrating endometriosis and postoperative pregnancy outcomes

Deep infiltrating endometriosis and postoperative pregnancy outcomes  By Selma Oransay

Although the current ESHRE guidelines state that there is no strong evidence to support surgical intervention to improve the spontaneous pregnancy rate in women with deep infiltrating endometriosis and advise Assisted reproduction technology irrespective of the severity of endometriosis, several studies…

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Omitted facet of endometriosis : mental health related to stigma

Omitted facet of endometriosis : mental health related to stigma By Nasuhi Engin Aydin

A team of clinical psychologists involved in women’s health led by Deniz Kocas has published a recent review on the mental health aspect of endometriosis patients in the European Journal of Obstetrics & Gynecology and Reproductive Biology. Endometriosis is a notoriously…

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Women With Endometriosis at a Higher Risk of Pregnancy Complications

Women With Endometriosis at a Higher Risk of Pregnancy Complications By Özge Özkaya

Apart from having difficulties conceiving, women with endometriosis also seem to have a significantly higher risk of adverse pregnancy outcomes. This is according to a new population-based study published in the Journal of Clinical Medicine. It is already known that…

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Assessing endometrial receptivity using menstrual blood samples in patients undergoing in-vitro fertilization

Assessing endometrial receptivity using menstrual blood samples in patients undergoing in-vitro fertilization By Eylül GÜN

Endometrial receptivity is the endometrium's capacity to allow the embryo the chance to adhere, infiltrate, and develop while ensuring an ideal microenvironment. When impaired, it is one of the two major factors contributing to infertility along with embryo quality by…

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Study May Explain How Tubal Endometriosis Causes Infertility

Study May Explain How Tubal Endometriosis Causes Infertility By Özge Özkaya

Tubal endometriosis damages the epithelial ultrastructure of the fallopian tubes or the tubes connecting the ovaries to the uterus along which an egg travels each month ready to be fertilized by a sperm cell. This could help explain why tubal…

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Moderate-to-severe Endometriosis and "The Cumulative live birth rate" in IVF Cycles

Moderate-to-severe Endometriosis and By Hale Goksever Celik

Infertility is one of the major symptoms in women with endometriosis. The incidence of endometriosis is approximately 10% in reproductive-aged women and up to 40-50% in infertile women. There are multifactorial mechanisms resulting in endometriosis-associated infertility such as anatomic distortion, impaired…

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When to start ART after laparoscopic treatment of endometriosis?

When to start ART after laparoscopic treatment of endometriosis? By Selma Oransay

Laparoscopy combined with histopathologic confirmation of endometriosis is the reference standard for diagnosing endometriosis. Additionally, laparoscopic surgery is considered the most effective way to approach infertility induced by endometriosis. The surgical factors influencing the outcome of treating the infertility of…

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Neuroendocrine pathway in endometriosis-related infertility

Neuroendocrine pathway in endometriosis-related infertility By Eylül GÜN

Dr. Robert Taylor from Jacobs School of Medicine, University at Buffalo presented on the newly defined neuroendocrine pathway and its role in endometriosis-related infertility and how implantation and pregnancy establishment might be disrupted in endometriosis at the Annual International Medical Conference of…

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Stem cells could be a good choice for therapeutic steps in many gynecologic disorders, including endometriosis

Stem cells could be a good choice for therapeutic steps in many gynecologic disorders, including endometriosis By Nasuhi Engin Aydin

Dr. Liu from the First Hospital of Jilin University, China, and colleagues from China and the USA have published their comprehensive review on the therapeutic gateways of stem cells in female genital tract disorders in a recent issue of Life…

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Antioxidant astaxanthin has promising effects on endometriosis-related infertility.

Antioxidant astaxanthin has promising effects on endometriosis-related infertility. By Nasuhi Engin Aydin

Dr. Rostami and colleagues from the Tehran University of Medical Sciences, Iran, have published a pioneering clinical study on the effects of antioxidant astaxanthin supplementation in infertile endometriosis patients in the scientific journal named Frontiers in Endocrinology. A complicated network…

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Transvaginal Hydro laparoscopy for diagnosing and treatment of early stages of endometriosis

Transvaginal Hydro laparoscopy for diagnosing and treatment of early stages of endometriosis By Selma Oransay

Transvaginal hydro laparoscopy is a minimally invasive procedure that allows the exploration of the female pelvis. An obliterated Douglas pouch by a fixed retroverted uterus, an ovarian endometrioma greater than 2 cm, and the presence of deeply infiltrated endometriosis are…

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First-line surgery or first-line ART: A real challenge both for the clinicians and infertile women having DIE without colorectal involvement

First-line surgery or first-line ART: A real challenge both for the clinicians and infertile women having DIE without colorectal involvement By Hale Goksever Celik

Deep infiltrating endometriosis (DIE) is defined as the presence of endometriotic lesions over 5 mm in depth under the peritoneal surface. These women suffer from chronic pelvic pain, dysmenorrhea, dyspareunia, chronic pelvic pain, bloody or painful bowel movements, and infertility. There…

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Does Endometriosis Surgery Increase the Rate of Pregnancy?

Does Endometriosis Surgery Increase the Rate of Pregnancy? By Özge Özkaya

Surgery to treat colorectal endometriosis leads to a high rate of pregnancy following the operation, found a new study published in the Journal of Minimally Invasive Gynecology. The authors of the study said, “studies with a high level of evidence…

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Histopathologic examination always has the final word in tubal endometriosis

Histopathologic examination always has the final word in tubal endometriosis By Nasuhi Engin Aydin

Hai-Ning Jiao and coworkers from the Department of Obstetrics and Gynecology of Shanghai Jiao Tong University School of Medicine, China, reported the salient features of 30 tubal endometriosis cases in the World Journal of Clinical Cases. Tubal endometriosis is characterized…

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Comparison of two surgical approaches for endometriosis.

Comparison of two surgical approaches for endometriosis. By Selma Oransay

Endometriosis is one of the causes of infertility in women. But the pathophysiology of infertility caused by endometriosis is not yet clear. Hormonal disorders, abnormal peritoneal function, distorted pelvic anatomy, and multiple cesarean deliveries are among the accused.  Dr. Li…

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Comparison of different IVF stimulation protocols for pregnancy success in infertile endometriosis patients

Comparison of different IVF stimulation protocols for pregnancy success in infertile endometriosis patients By Hale Goksever Celik

Women with endometriosis may suffer from reproductive problems up to an incidence of 50%. Several pathophysiological mechanisms including anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis and sperm movements are the most responsible for the development of endometriosis-associated infertility.…

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The optimal endometrial preparation protocol in FET cycles of women with endometriosis.

The optimal endometrial preparation protocol in FET cycles of women with endometriosis. By Selma Oransay

Endometriosis can create infertility and may require treatment with assisted reproductive technology (ART) to induce pregnancy. However, the current literature rarely discusses the optimal endometrial preparation protocol in thawed-frozen embryo transfer (FET) cycles for endometriotic patients. Dr.Jin. group from the Reproductive…

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Diaphragmatic Endometriosis: a Call for Awareness

Diaphragmatic Endometriosis: a Call for Awareness By Nasuhi Engin Aydin

Dr. Pagano and colleagues from the Department of Gynecology and Obstetrics, University of Bern, Switzerland, have published a prospective cohort study on diaphragmatic involvement in endometriosis patients in a recent issue of “The Journal of Minimally Invasive Gynecology”. Endometriosis is…

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Sexual function in infertile women with PCOS and endometriosis

Sexual function in infertile women with PCOS and endometriosis By Hale Goksever Celik

Women with endometriosis suffer from several symptoms and signs including dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility which have a detrimental effect on their quality of life. Sexual dysfunction also is a common problem for endometriosis patients due to complex…

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Does endometrioma size have an effect on IVF/ICSI outcomes?

Does endometrioma size have an effect on IVF/ICSI outcomes? By Hale Goksever Celik

Assisted reproductive technologies including IVF/ICSI can be suggested as the therapeutic option in women with endometriosis-associated infertility. In literature, there is a controversy regarding the influence of endometrioma size on IVF/ICSI outcomes. The group led by Drs Chapron and Santoulli…

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Endometriosis and IBS Have Different Comorbidities

Endometriosis and IBS Have Different Comorbidities By Özge Özkaya

Comorbidities of endometriosis and irritable bowel syndrome (IBS) are different despite several overlapping symptoms, according to a new study published in the scientific journal Human Reproduction. These comorbidities are usually related to the organ systems that are primarily involved in…

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Time has come to learn more about endometriosis and take action!

Time has come to learn more about endometriosis and take action! By Eylül GÜN

It has been a long time since endometriosis was defined. Extensive population studies have shown that around 10% of women suffer from this condition. Depending on its severity, it alters the various functions of the body and causes the patients…

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Does the timing of endometriosis diagnosis affect optimal infertility treatment?

Does the timing of endometriosis diagnosis affect optimal infertility treatment? By Selma Oransay

Based on a retrospective population-linked data study in "Human Reproduction", the ESHRE journal club featured a detailed discussion with 50 participants, patients’ representatives, and experts (Paola Vigano´, Mathew Leonardi, Thomas D’Hooghe, Louise Hull), together with the authors of the original article, mainly…

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Endometriosis-associated infertility: How to manage?

Endometriosis-associated infertility: How to manage? By Hale Goksever Celik

Although the underlying reason for endometriosis has not been fully established, there is an association between endometriosis and infertility. Endometriosis is thought to be involved in 40-50 percent of infertility cases. However, natural conception can still occur even in women…

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The effect of chronic endometritis on pregnancy outcomes in infertile women having minimal/mild endometriosis

The effect of chronic endometritis on pregnancy outcomes in infertile women having minimal/mild endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease that is frequently diagnosed in reproductive-aged women. Infertility can be associated with endometriosis in these women depending on several pathophysiologic mechanisms such as anatomic distortion, and implantation failure. Thus pregnancy rate is so important, especially…

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The association between inflammatory cytokines and fertility in women with endometriosis

The association between inflammatory cytokines and fertility in women with endometriosis By Hale Goksever Celik

Women with endometriosis suffer not only from a broad spectrum of symptoms including pain including dysmenorrhea, dyspareunia, and chronic pelvic pain but also fertility problems. Endometriosis-associated infertility develops depending on a combination of several mechanisms such as distorted pelvic anatomy,…

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The consequence of COVID-19 pandemic on endometriosis patients

The consequence of COVID-19 pandemic on endometriosis patients By Selma Oransay

The relevant policies and restrictions concerning Covid-19 have prevented patients from accessing medical care. Similarly, standard care for endometriosis patients has also been negatively impacted by postponed or canceled appointments and suspended surgeries across the countries. Women trying to cope…

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The evaluation of sexual dysfunction in infertile women

The evaluation of sexual dysfunction in infertile women By Eylül GÜN

Infertility constitutes a serious health problem in women and men worldwide. The most common causes of women’s infertility are reported to be endometriosis and polycystic ovarian syndrome. The prevalence of infertility in women with endometriosis is as high as 50%.…

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The underlying reason of implantation failure in women with endometriosis-associated infertility

The underlying reason of implantation failure in women with endometriosis-associated infertility By Hale Goksever Celik

Endometriosis is most frequently encountered in reproductive-aged women, with a prevalence of 10-15% in the general population. However, endometriosis is more frequently diagnosed in infertile women, with a prevalence of 25-40%. Although the exact mechanism explaining the association between endometriosis…

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A comparison of endometriosis Classifications: rASRM, EFI or Enzian?

A comparison of endometriosis Classifications: rASRM, EFI or Enzian? By Selma Oransay

None of the endometriosis classifications provide a clinically valuable system since the very first description of the disease in 1860. One unique terminology to describe the localization and the extension of the disease is needed, which should be the same…

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Quality of life assessment in women with endometrioma

Quality of life assessment in women with endometrioma By Eylül GÜN

Like most chronic diseases, endometriosis poses a significant risk of diminishing the quality of life in patients suffering from it, particularly with its most considerable symptom; chronic pelvic pain. Although it is known that endometriosis is more common in East…

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Is intrauterine insemination effective in women having endometriosis-associated infertility?

Is intrauterine insemination effective in women having endometriosis-associated infertility?  By Hale Goksever Celik

The most common presenting complaints of women with endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Affected women demand therapy for these symptoms of endometriosis, notably fertility problems. Several underlying mechanisms have been proposed to explain endometriosis-associated infertility including anatomic…

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The necessity of laparoscopy for unexplained infertility.

The necessity of laparoscopy for unexplained infertility. By Selma Oransay

The standard for accepting a couple as "infertile" is the inability to conceive after 12 months of regular unprotected intercourse. When this condition is met, assessing the number of motile sperm in the male partner and certifying the patency at…

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The Role of Endometrial Cytokines on the Infertility in Endometriosis Patients

The Role of Endometrial Cytokines on the Infertility in Endometriosis Patients By Eylül GÜN

The intrauterine microenvironment and underlying immunological mechanisms in endometriosis pathogenesis have been a popular research topic, mainly due to the efforts to comprehend the reason to elucidate infertility that these patients suffer from. Because of their superiority to other immune…

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Envorinmental metals harmful for female reproductivity

Envorinmental metals harmful for female reproductivity By Selma Oransay

Heavy metals exposure in a wide range of ways is one of the main causes of increased infertility. According to the 2003 National Health Survey, nearly every pregnant woman in the USA is exposed to at least 43 hazardous chemicals…

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Pain alone is not a specific predictor for endometriosis diagnosis

Pain alone is not a specific predictor for endometriosis diagnosis By Hale Goksever Celik

The most common symptoms and signs of women with endometriosis include dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. However, diagnostic delay still occurs due to the broad clinical spectrum of the disease and the absence of non-invasive diagnostic biomarkers. Gordon et…

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The quality of life and mental health in endometriosis patients

The quality of life and mental health in endometriosis patients By Eylül GÜN

One of the most important aspects of having a chronic illness comes with its relative effect on the patients’ quality of life and mental health status. Being among the most debilitating diseases in women in the reproductive period, endometriosis is…

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How Likely Am I to Conceive After Endometriosis Surgery?

How Likely Am I to Conceive After Endometriosis Surgery? By Özge Özkaya

Women with superficial peritoneal endometriosis and just one type of lesion are more likely to conceive after surgery, according to a new study published in the International Journal of Gynecology and Obstetrics.  This is important because patients will be better…

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The higher the Endometriosis Fertility Index, the higher the chance of getting pregnant

The higher the Endometriosis Fertility Index, the higher the chance of getting pregnant By Hale Goksever Celik

The women who desire to get pregnant may also suffer from fertility problems depending on several mechanisms such as anatomic distortion, peritoneal adhesions, tubal dysfunction, impaired quality of oocytes, and impaired endometrial receptivity. One of the most important problems in…

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An Overview on Treatment of endometriosis

An Overview on Treatment of endometriosis By Selma Oransay

There are different guidelines by different gynecological societies for the diagnosis and treatment of endometriosis, which is an extremely complex illness.  Kalaitzopoulos and Samartzis et al. from Switzerland worked on and compared six national and two international widely used guidelines to…

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Preoperative Neutrophil-to-Lymphocyte Ratio for prediction of postoperative pregnancy

Preoperative Neutrophil-to-Lymphocyte Ratio for prediction of postoperative pregnancy By Hale Goksever Celik

Among women with endometriosis, 30 to 50 percent are estimated to have infertility, and 25-50% of infertile patients are found to have endometriosis. Anatomic distortion, diminished tubal peristalsis, diminished sperm movements, dysfunctional folliculogenesis, luteal phase dysfunctions, and alterations in endometrial…

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The new Endometriosis Surgical Complexity Classification: AAGL 2021

The new Endometriosis Surgical Complexity Classification: AAGL 2021 By Selma Oransay

Multiple endometriosis categorizations have been approved in the recent forty years. The American Fertility Society proposed ASRM with a desire to score the impact of the endometriosis in 1996,  which was updated several times later (rASRM), to predict infertility after laparoscopic operations. For…

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It is "pain" that causes sleep disturbances and fatigue in endometriosis patients

It is By Bahar Yuksel

Endometriosis has been studied previously about its effects on quality of life and the possible effects on sleeping periods. The study conducted by Federica Facchin et al. questioned the reason for endometriosis to cause sleep disturbance. The authors have divided…

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Assisted Reproductive Technology Outcomes in Women with and without Endometriosis

Assisted Reproductive Technology Outcomes in Women with and without Endometriosis By Selma Oransay

Endometriosis causes infertility in one-third of patients, while in approximately 25-35% of infertile women, the cause is endometriosis.  The primary interest and the question of Moss et al. from the University of Queensland, Brisbane, Australia was "the differences in the…

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Awareness is the first step toward endometriosis treatment

Awareness is the first step toward endometriosis treatment By Dr. Youngran Park

We want to reiterate the importance of endometriosis, by handling the paper entitled "Endometriosis awareness: screaming at the top of our voices" published on April 2021 in the journal “Women & Health”. The Endometriosis Awareness Month of 2021 was a little different,…

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Non-invasive Construction of Endometrial Organoids

Non-invasive Construction of Endometrial Organoids By Eylül GÜN

Organoids are 3D culture structures established in vitro and they reflect the aspects of the tissue or the organ they represent. They are seen as important tools in the evaluation of normal development, disease course, and the prediction of the…

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The clues for pain and infertility in endometriosis/adenomyosis complex

The clues for pain and infertility in endometriosis/adenomyosis complex By Nasuhi Engin Aydin

Drs. Gruber and Mechsner from Charite University-Berlin, Germany published their comprehensive review on pathophysiological background of endometriosis and adenomyosis in the scientific periodical “Cells”. Chronic pain and fertility problems are the main clinical issue in endometriosis and adenomyosis patients. In order to…

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Adenomyosis, fertility, and obstetric outcomes

Adenomyosis, fertility, and obstetric outcomes By Hale Goksever Celik

Adenomyosis is the localization of endometrial glandular and stromal cells within the myometrial wall. Although magnetic resonance imaging has a higher ability to discriminate and identify adenomyosis, transvaginal ultrasonography is a cheaper, more accessible, and practical method in daily clinical practice for…

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MicroRNAs in the pathogenesis of endometriosis and infertility

MicroRNAs in the pathogenesis of endometriosis and infertility By Eylül GÜN

The gold standard in the diagnosis of endometriosis is laparoscopy and histopathological diagnosis, however search for a non-invasive method has been ongoing. Some biomarkers such as Cancer Antigen 125 have been thought to be useful, but because of their low…

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Postoperative ovulation induction in infertile women with minimal to mild endometriosis

Postoperative ovulation induction in infertile women with minimal to mild endometriosis By Hale Goksever Celik

Infertility is an important problem that is encountered in 30-50% of women with endometriosis. Several etiopathogenetic mechanisms for the development of reproductive problems in women with endometriosis have been proposed including abnormal peritoneal microenvironment, ovarian dysfunction and/or decreased oocyte quality,…

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Ultrasonographic signs of adenomyosis, surgery and infertility in endometriosis patients

Ultrasonographic signs of adenomyosis, surgery and infertility in endometriosis patients By Bahar Yuksel

Adenomyosis is simply defined as the presence of endometrial glands and stroma within the uterine myometrium and is related to severe menstrual bleeding, pain, and infertility. Previous reports demonstrated the coexisting of endometriosis and adenomyosis is common. In the present…

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Peritoneal Pockets and Endometriosis

Peritoneal Pockets and Endometriosis By Özge Özkaya

Infertile women with peritoneal pockets had more endometriosis compared to women without pockets according to a study published in the Journal of Obstetrics and Gynaecology Canada. Severe pelvic pain was also associated with the presence of pockets and the presence…

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The need for the standardization of diagnostic protocols for "adenomyosis"

The need for the standardization of diagnostic protocols for By Nasuhi Engin Aydin

Dr. Squillace and associates from Brasilian Academic and Health Centers published their paper titled “Adenomyosis and in vitro fertilization impacts- a literature review” in a recent issue of "JBRA Assisted Reproduction". As common gynecological ailment adenomyosis frequently coexists with endometriosis.…

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Low-Dose Aspirin as a Potential Treatment for Endometriosis-Related Infertility

Low-Dose Aspirin as a Potential Treatment for Endometriosis-Related Infertility By Özge Özkaya

Treatment with low-dose aspirin could downregulate progesterone resistance and increase the expression of leukemia inhibitory factor (LIF) during the implantation window, according to a study that used a rat model of endometriosis. This, in turn, could improve endometrial receptivity and…

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Postoperative infertility management using Endometriosis Fertility Index in endometriotic women

Postoperative infertility management using Endometriosis Fertility Index in endometriotic women By Selma Oransay

"Endometriosis Fertility Index '' score, described by the World Endometriosis Society in 2017, is a robust score and assists to predict the spontaneous pregnancy rate of women with endometriosis, within 3 years after their operation. Its calculation is possible by patient…

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What Happens to Endometriosis Patients After Endometriosis Surgery?

What Happens to Endometriosis Patients After Endometriosis Surgery? By Özge Özkaya

Although few patients with endometriosis who undergo a hysterectomy need repeat surgery, up to 25% of them need minor surgery. Around 20% of patients who undergo conservative surgery with ovarian preservation require additional endometriosis surgery. Up to one in three…

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Optimal management of infertility in endometriosis patients

Optimal management of infertility in endometriosis patients By Hale Goksever Celik

Pelvic pain and infertility are the main symptoms of endometriosis patients. Although the pathophysiological mechanism for infertility is not clearly understood, there are several theories explaining decreased fertility potential in women with endometriosis. Ata and Telek, from Koc and Istanbul Universities…

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The association of chronic endometritis, endometriosis and tubal infertility

The association of chronic endometritis, endometriosis and tubal infertility By Selma Oransay

Holzer et al. from the Department of Gynecologic Endocrinology and Reproductive Medicine of  Medical University of Vienna, Austria, set up apilot prospective cohort study to evaluate the relationship between chronic endometritis, infertility and endometriosis. The results of the study were recently…

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Fertilization rate and pregnancy outcome in IVF cycles of endometriosis.

Fertilization rate and pregnancy outcome in IVF cycles of endometriosis. By Selma Oransay

Endometriosis affects the pelvic cavity, uterus, ovaries and causes impaired fertility as a result. The chronic inflammatory nature of this disease negatively impacts the oocyte quality, maturation, and fertilization. Obviously, fewer oocytes can be harvested in the IVF cycles of…

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Endometrial receptivity after the removal of ovarian endometriotic cysts

Endometrial receptivity after the removal of ovarian endometriotic cysts By Nasuhi Engin Aydin

Mikhaleva and associates from the "Russian Research Institute of Human Morphology" published their results in “Reproductive Sciences” yielding their novel morphological findings of eutopic endometria in patients following surgical excision of endometriotic ovarian cysts. Current therapeutic measures are targeting to…

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Impaired fertility potential in endometriosis patients

Impaired fertility potential in endometriosis patients By Hale Goksever Celik

Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis and sperm movements. Garcia-Fernandez and García-Velasco, from Edinburgh, UK and Madrid, Spain, published a mini-review titled “Endometriosis and Reproduction: What We Have…

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The improvement of fertility rate and symptoms of superficial endometriosis following laparoscopic peritoneal stripping

The improvement of fertility rate and symptoms of superficial endometriosis following laparoscopic peritoneal stripping By Selma Oransay

Pain, in the form of diverse entities, including dyspareunia, dysuria, dyschezia, is the main symptom of endometriosis patients. The severity of pain is independent of the extent and the location of the disease, and generally causes a negative impact on…

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Live Birth Rate in Women Who Underwent Fresh Embryo Transfer Using Freshly Retrieved Donor Oocytes

Live Birth Rate in Women Who Underwent Fresh Embryo Transfer Using Freshly Retrieved Donor Oocytes By Hale Goksever Celik

One of the important clinical findings in women with endometriosis is reproductive problems. Infertility can be encountered in up to 50% of women with endometriosis and up to 50% of women with infertility can be diagnosed with endometriosis. Several pathophysiologic…

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Egg Freezing for Endometriosis: Should she rush - Tomer Singer, MD

Egg Freezing for Endometriosis: Should she rush - Tomer Singer, MD By Özge Özkaya

In this presentation, Dr. Tomer Singer, a fertility specialist and the medical director at Shady Grove Fertility in Manhattan, New York talks about egg freezing and its importance for women with endometriosis. He emphasizes the importance of having an endometriosis…

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Implantation failure in endometriosis patients - Jovana Lekovich, MD., PhD.

Implantation failure in endometriosis patients - Jovana Lekovich, MD., PhD. By Hale Goksever Celik

Endometriosis is one of the leading reasons for infertility due to decreased oocyte/embryo quality, fertilization ability, tubal function, and aberrant endometrial receptivity. Whether this failure is caused by oocyte/embryo or eutopic endometrium is one of the investigated topics in endometriosis…

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Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD

Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD By Selma Oransay

The removal of endometrioma may affect ovarian reserve because healthy follicles near endometrioma could also be excised during this procedure. Another concern about the ovarian reserve is that it may be already low before the surgery. Anti Mullerian Hormone (AMH)…

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In vitro fertilization protocols in endometriosis patients - Pinar Kodaman, MD., PhD.

In vitro fertilization protocols in endometriosis patients - Pinar Kodaman, MD., PhD. By Hale Goksever Celik

Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis, and sperm movements. Even though the disease stage and presence of endometrioma is negatively correlated with infertility, it is unpredictable which women…

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Endometrioma size and anti-Müllerian hormone levels

Endometrioma size and anti-Müllerian hormone levels By Hale Goksever Celik

Endometriotic lesions are encountered in different locations in the pelvic cavity, including but not limited to the ovaries, the pouch of Douglas, the ureters, the bladder, and the bowel. Cystic endometriosis lesions located in the ovary are called "endometrioma". Endometriomas have…

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Endometriosis and Natural Killer Cell Immunity

Endometriosis and Natural Killer Cell Immunity By Dr. Youngran Park

It is known that approximately 25 to 50% of infertile women have endometriosis, and 30% to 50% of the women with endometriosis have infertility and recurrent pregnancy loss. Previous studies have shown that women suffering endometriosis have abnormal NK cell…

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It is time for non-invasive tests for peritoneal endometriosis diagnosis

It is time for non-invasive tests for peritoneal endometriosis diagnosis By Nasuhi Engin Aydin

Maria Szubert with colleagues from Lodz Medical University, Poland, investigated the possibility of potential diagnostic biomarkers in the eutopic endometrial tissue from peritoneal endometriosis patients and published their results in the "Journal of Gynecology Obstetrics and Human Reproduction". Currently, diagnostic…

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Fallopian tube endometriosis

Fallopian tube endometriosis By Bahar Yuksel

Endometriosis affects various tissues including pelvic and extra-pelvic organs. Fallopian tube endometriosis is not a widely studied topic in endometriosis, hence the real incidence is unknown as not all studies evaluate microscopically diagnosed Fallopian tube endometriosis. In the retrospective database…

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Stem cell and exosome therapy

Stem cell and exosome therapy By Dr. Youngran Park

These days, two experimental methods, stem cell, and exosome therapy are getting more attention. Stem cell therapy has shown promising effects in regenerative medicine, including myocardial infarction, nervous system impairment, retinal damage, and liver diseases. Recent studies showed that stem…

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Iron overload in follicular fluid in Endometriosis

Iron overload in follicular fluid in Endometriosis By Yu Yu

Around 20-50% of women with endometriosis have an infertility issue. Assisted reproductive technology (ART) is a common procedure to assist women with endometriosis to become pregnant. However, one major problem remains that women with endometriosis tend to have fewer oocytes…

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International experts commentary for assisted fertility treatment facilities amidst COVID-19

International experts commentary for assisted fertility treatment facilities amidst COVID-19 By Nasuhi Engin Aydin

A multinational and multi-institutional commentary led by Dr. Alviggi from Italy and Dr.Esteves from Brazil has addressed important issues on assisted reproductive technology treatment amid COVID-19 lockdown suggesting remedies in the journal of "Reproductive Biology and Endocrinology" May 2020 issue.…

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Case-control study to develop a questionnaire for early diagnosis of endometriosis

Case-control study to develop a questionnaire for early diagnosis of endometriosis By Nadire Duru

Endometriosis, which affects 5–10% of women of reproductive age, is a chronic gynecological disease characterized by the presence of endometrial glands and stroma outside the uterus, associated with several discomforts such as pelvic pain, menstrual disorders, and infertility. Ultrasound evaluation…

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Neglected needs of endometriosis and infertility patients during COVID-19 pandemic

Neglected needs of endometriosis and infertility patients during COVID-19 pandemic By Timur Seckin

With the global outbreak of the COVID-19, hospitals canceled surgeries and people are afraid of going to hospitals. However, chronic diseases still need to be managed. Rowe H. and Quinlivan J., researchers from Australia, pointed out the neglected needs of…

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Resveratrol for infertility: A frenemy?

Resveratrol for infertility: A frenemy? By Selma Oransay

Ovarian aging is defined by an age-specific decline of the functional ovarian reserve. Female ovarian reserve declines progressively with increasing chronological age. Chronic damage by reactive oxygen species results in deterioration and aging through mitochondrial dysfunction, telomere shortening, cohesion dysfunction,…

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Hysterolaparoscopy Plus Assisted Reproduction Improves Fertility in Women with Endometriosis

Hysterolaparoscopy Plus Assisted Reproduction Improves Fertility in Women with Endometriosis By Özge Özkaya

Hysteroscopy and laparoscopic surgery is an effective and reliable therapeutic procedure, confirmed a study published in the "Journal of Clinical Medicine". The approach is even more effective when combined with assisted reproductive techniques such as artificial insemination and in vitro…

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Fertility preservation protocols in women with endometriosis

Fertility preservation protocols in women with endometriosis By Hale Goksever Celik

Infertility is one of the major symptoms in women with endometriosis. Childbearing at a delayed age is preferred by the majority of women recently who consult for the demand for fertility preservation procedures. There are several techniques for fertility preservation…

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The Relationship Between Dyspareunia and Infertility in Endometriosis

The Relationship Between Dyspareunia and Infertility in Endometriosis By Selma Oransay

Wahl et al. from the Center of Pelvic Pain and Endometriosis British Columbia Women's Hospital, Vancouver, Canada studied with endometriotic patients suffering from dyspareunia who were referred to their center and built a cross-sectional study to investigate the relations between…

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Could my Peritoneal Fluid Have a Negative Effect on my Partner’s Sperm?

Could my Peritoneal Fluid Have a Negative Effect on my Partner’s Sperm? By Özge Özkaya

The peritoneal fluid of women with endometriosis could negatively affect the quality and functionality of sperm, according to a study by Spanish researchers. This could explain infertility linked to the male partners of women with endometriosis. The knowledge could also…

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The association between endometriosis and ectopic pregnancy

The association between endometriosis and ectopic pregnancy By Hale Goksever Celik

Endometriosis is a chronic inflammatory disease with a broad spectrum of symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain and fertility problems. It has been understood in the light of scientific evidence that endometriosis is also associated with other poor…

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What we should know in managing infertility related to endometriosis?

What we should know in managing infertility related to endometriosis? By Nasuhi Engin Aydin

Dr. Llarena and associates made a comprehensive review of the causes of infertility in endometriosis and adverse effects of surgical procedures in Clinical Medicine Insights: Reproductive Health. Infertility is an important issue in endometriosis patients and about 30-50 % face infertility.…

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When to do - and when not to do surgery for endometriosis

When to do - and when not to do surgery for endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. It was estimated to affect about 176 million women in the world and usually causes pelvic pain and infertility. Unfortunately, the current understanding of this disease is very limited. Though there are many remaining questions,…

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Recent advances in the diagnosis and treatment of endometriosis

Recent advances in the diagnosis and treatment of endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. The most common complaints of women with endometriosis are pain and fertility problems. Although many advanced types of research about the etiology, differential diagnosis and treatment have been…

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The effect of endometriosis on implantation in women with endometriosis associated infertility

The effect of endometriosis on implantation in women with endometriosis associated infertility By Hale Goksever Celik

One of the most common clinical findings of women with endometriosis is fertility problems. Women with endometriosis often benefit from in vitro fertilization methods to get pregnant. However, whether there is a detrimental effect of endometriosis on in vitro fertilization outcomes…

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A rigorous literature review on endometriosis

A rigorous literature review on endometriosis By Irem Onur

Bulun SE. et al., from Feinberg School of Medicine, Northwestern University, Chicago, conducted a rigorous literature review on endometriosis. This outstanding review by Dr. Bulun et al. addresses the definition, remarkable medical features, clinically useful research findings, prevalence and distribution,…

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Increased obstetrical complications after ART therapy in endometriosis patients.

Increased obstetrical complications after ART therapy in endometriosis patients. By Selma Oransay

To examine the impact of endometriosis and adenomyosis on ART therapy, Harada et al. from the Department of Obstetrics and Gynecology of Tottori University, Japan, planned a prospective cohort study and published their results recently in PLoS One.  The study…

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Infertility in women with endometriosis

Infertility in women with endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. The most common presenting complaints are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Despite extensive research, the etiopathogenic mechanism underlying the two has not been fully elucidated. Although human…

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Babies Born Lighter May Have a Higher Risk of Developing Endometriosis Later in Life

Babies Born Lighter May Have a Higher Risk of Developing Endometriosis Later in Life By Özge Özkaya

Being exposed to growth restriction before birth seems to be associated with a higher risk of developing endometriosis during a woman’s reproductive years. Other factors such as having fewer liveborn children and prior infertility problems, also seem to be important…

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The predictors for the coexistence of uterine leiomyomas and endometriosis

The predictors for the coexistence of uterine leiomyomas and endometriosis  By Hale Goksever Celik

Uterine leiomyomas are the most common gynecological benign tumors affecting 20-25% of reproductive-aged women. Abnormal bleeding, pelvic pain, pelvic pressure, and infertility are major symptoms of these tumors. Endometriosis is another gynecological disease encountered in 10-15% of reproductive-aged women. The…

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Does Endometriosis Reduce Ovarian Reserve?

Does Endometriosis Reduce Ovarian Reserve? By Özge Özkaya

Markers of ovarian reserve are worse in infertile women with endometriosis compared to women who cannot conceive due to male factor infertility regardless of whether or not they have had ovarian surgery. This finding is important because it suggests that…

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Proposed algorithm for a clinical diagnosis of endometriosis.

Proposed algorithm for a clinical diagnosis of endometriosis. By Selma Oransay

This recently published article in the American Journal of Obstetrics and Gynecology is about the challenge of diagnosing endometriosis, its impact on women's daily life and authored by Agarwal et al. from The University of California, San Diego, CA, USA. Authors called attention…

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Impact of Endometriosis-Related Adhesions on Quality of Life among Infertile Women

Impact of Endometriosis-Related Adhesions on Quality of Life among Infertile Women By Dr. Youngran Park

Endometriosis is considered the most common cause of pelvic adhesions in women. It is considered one of the main underlying causes of the development of adhesions. Adhesions are bands of connective tissue, which connect two different tissues that are normally…

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Polymorphisms of STAT4 gene in the pathogenesis of endometriosis

Polymorphisms of STAT4 gene in the pathogenesis of endometriosis By Dr. Youngran Park

Endometriosis is one of the most common gynecological diseases in reproductive-age women characterized by the occurrence of endometrial tissue outside the uterine cavity. Researchers have put forward numerous hypotheses to explain ectopic endometrial tissue, and the bulk of the evidence…

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Endometriosis and infertility: current concepts

Endometriosis and infertility: current concepts By Nasuhi Engin Aydin

Hungarian and US scientists have published a comprehensive review on infertility related to endometriosis in Frontiers in Endocrinology, November 2018 issue.  Endometriosis is a common entity in women of reproductive age which often leads to infertility. Compiled research data reveal…

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Which comes first in endometriosis management: In vitro fertilization or surgery?

Which comes first in endometriosis management: In vitro fertilization or surgery? By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence is found to be 7%–10%, but among infertile women, it increases up to 50%. Early diagnosis and personalized management are important to…

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Endometrioma, Fertility, and Assisted Reproduction

Endometrioma, Fertility, and Assisted Reproduction By Dr. Youngran Park

Endometriosis can negatively impact a woman’s health and quality of life. Surgery has been considered the primary treatment to overcome infertility in cases of ovarian endometrioma. Patients struggling with endometriosis often pursue assisted reproductive technologies (ART) due to fertility issues.…

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The association between the development of endometriosis and dietary habits

The association between the development of endometriosis and dietary habits By Hale Goksever Celik

Endometriosis is a chronic disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence is found to be approximately 10% in the general population. Endometriosis is associated with infertility, pelvic pain, and increased…

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HOXA-10 levels are related to infertility in endometriosis patients

HOXA-10 levels are related to infertility in endometriosis patients By Demet Candaş Green

The current study by Ozcan et al., published in the European Journal of Obstetrics & Gynecology and Reproductive Biology aimed to investigate the levels of HOXA-10 gene in fertile versus infertile women with endometriosis. HOXA-10 protein (expressed by HOXA-10 gene)…

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Not True That Women With Endometriosis Can’t Conceive

Not True That Women With Endometriosis Can’t Conceive By Özge Özkaya

The common assertion that women with endometriosis are unlikely to conceive is countered by a new study published in The European Journal of Contraception & Reproductive Health Care. This finding supports the need for healthcare and information to address all…

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How to predict natural conception in women underwent endometriosis surgery?

How to predict natural conception in women underwent endometriosis surgery? By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The most common symptoms are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. The prevalence of endometriosis increases in the infertile population. Thus, the important…

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The diagnosis and management of endometriosis in Korea

The diagnosis and management of endometriosis in Korea By Selma Oransay

The Korean Society of Endometriosis has scrutinized the present published literature of endometriosis in the domestic and international platform to provide new guidelines and the clinical management of the disease. The study was recently published in the journal "Obstetrics and Gynecology…

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Could Endometriosis-Related Infertility Be Genetic?

Could Endometriosis-Related Infertility Be Genetic? By Özge Özkaya

Researchers identified genetic polymorphisms or individual differences in two genes called AMA5 and KAZN among women with endometriosis who were infertile and control women who were fertile. The identification of these polymorphisms could help scientists better understand why some women…

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Non-assisted reproductive technology treatment: Is it effective in infertile patients with advanced endometriosis?

Non-assisted reproductive technology treatment: Is it effective in infertile patients with advanced endometriosis? By Hale Goksever Celik

The marriage and childbearing ages delay due to the life-style changes in developed countries. As a result, advanced age becomes a major concern in infertility treatments which consist of non-ART and ART modalities. Non-ART treatments include mild ovarian stimulation together…

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Shedding light on the fertility preservation debate in women with endometriosis: a swot analysis.

Shedding light on the fertility preservation debate in women with endometriosis: a swot analysis. By Deniz Kocas

There is little known about fertility preservation in women with endometriosis. Researchers from France and Switzerland conducted a SWOT (strengths, weaknesses, opportunities, and threats) analysis to better understand this topic. Applied to clinical problems, SWOT gives a thorough analysis of…

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Cosmetics and some household products could be responsible for worsening endometriosis.

Cosmetics and some household products could be responsible for worsening endometriosis. By Selma Oransay

A controlled clinical study recently published in the Journal of Human Reproductive Sciences,  composed by Nazir et al. from the University of Health Sciences, Lahore, Pakistan. The study compared the blood diethyl hexyl phthalate (DEHP) levels of fifty infertile women laparoscopically diagnosed…

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Toxic Pelvic Cavity and Infertility

Toxic Pelvic Cavity and Infertility By Murat Osman

Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterine cavity and has an incidence of approximately 10% in women of reproductive age. Thus, it is an important consideration in chronic pelvic pain and infertility…

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Reduced pain and increased fertiliy rates after surgery for colorectal endometriosis

Reduced pain and increased fertiliy rates after surgery for colorectal endometriosis By Selma Oransay

This prospective cohort study which recently published in AOGS by Hudelist et al. from Oslo University, Norway is about their one hundred thirty-four laparoscopic operations of DIE cases performed between 2011 and  2016, in a tertiary center in Oslo. The…

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Should I Have Surgery Before Trying to Conceive?

Should I Have Surgery Before Trying to Conceive? By Özge Özkaya

The presence of rectouterine nodules is associated with a lower chance of becoming pregnant with in vitro fertilization (IVF), according to a study published in the Journal of Gynecology Obstetrics and Human Reproduction. This finding is important as it can…

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Vitamin C supplementation in the patients with endometriosis undergoing in vitro fertilization-embryo transfer

Vitamin C supplementation in the patients with endometriosis undergoing in vitro fertilization-embryo transfer By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Women having endometriosis present with dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Thus, infertility remains a significant problem for women with endometriosis. Endometriosis is…

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Health-related quality of life in women with Endometriosis and Rheumatoid Arthritis

Health-related quality of life in women with Endometriosis and Rheumatoid Arthritis By Murat Osman

Endometriosis is a chronic inflammatory disease that is defined by the presence of ectopic endometrial tissue outside of the uterus. Unfortunately, endometriosis continues to be a leading cause of chronic pelvic pain and long-term morbidity in women of reproductive age.…

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Is there a definitive guideline for the surgical management of endometriosis?

Is there a definitive guideline for the surgical management of endometriosis? By Murat Osman

Endometriosis is a chronic inflammatory disease that is defined by the presence of ectopic endometrial tissue outside of the uterus. Unfortunately, endometriosis continues to be a leading cause of chronic pelvic pain in women of reproductive age. This article titled,…

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Predictors of psychological distress

Predictors of psychological distress By Deniz Kocas

Studies have now established that endometriosis can negatively impact mental health and quality of life, however, some studies show that not all women with endometriosis are necessarily more distressed than healthy women. This suggests that individual differences may explain women’s’…

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Difficulties Associated with Diagnosing Ascites and Encapsulating Peritonitis in Endometriosis

Difficulties Associated with Diagnosing Ascites and Encapsulating Peritonitis in Endometriosis By Kasthuri Nair

De Magalhães et al. recently published a paper titled “Ascites and Encapsulating Peritonitis in Endometriosis: a Systematic Review with a Case Report” in Revista Brasileira de Ginecologia e Obstetrícia. The team from the Universidade Federal do Ceará and the Universidade…

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Is the Endometriosis Fertility Index Reliable?

Is the Endometriosis Fertility Index Reliable? By Kasthuri Nair

Zhang et al. recently published a paper titled “Prediction of Endometriosis Fertility Index in patients with endometriosis-associated infertility after laparoscopic treatment” in Reproductive BioMedicine Online. The research group from the West China Second University Hospital in Sichuan University wanted to…

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Using the "Mushroom Cap" sign to describe endometriotic masses

Using the By Murat Osman

Endometriosis is a disease whereby ectopic endometrial cells attach and grow outside of the uterus. A number of imaging techniques have been used to evaluate and assess endometriotic lesions. Magnetic resonance imaging (MRI) is a type of imaging modality used…

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Endocrine and inflammatory factors in current understanding of endometriosis

Endocrine and inflammatory factors in current understanding of endometriosis By Yu Yu

There are three forms of endometriosis: peritoneal, ovarian, and deep infiltrating. All three forms consist of endometriotic lesions containing endometrial glands, stroma, nerves, blood vessels, and inflammatory cells. Endometriosis symptoms can be accounted by these elements and the involving organs.…

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Endometrial stem cells and Endometriosis

Endometrial stem cells and Endometriosis By Dr. Youngran Park

Human endometrium is a cyclically proliferative tissue, and this monthly regeneration is likely mediated by endometrial stem (or progenitor) cells.The upper functional layer of the endometrium breaks down and is shed into the uterine cavity during menstruation. Re-epithelialization and repair…

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Endometriosis can Adversely Affect Oocyte Quality

Endometriosis can Adversely Affect Oocyte Quality By Kasthuri Nair

Kasapoglu et al. recently published a study in Gynecological Endocrinology titled “Detrimental effects of endometriosis on oocyte morphology in intracytoplasmic sperm injection cycles: a retrospective cohort study.” In this paper, they compared the oocytes recovered from women who have endometriosis…

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The Chance of Getting Pregnant of a Woman with Endometriosis May Soon Be Predictable

The Chance of Getting Pregnant  of a Woman with Endometriosis May Soon Be Predictable By Özge Özkaya

Researchers have found a new way of predicting whether or not an embryo will be able to successfully implant into the womb of a woman with endometriosis. These findings could make it possible to predict whether she is likely to…

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Does Endometriosis Cause Infertility?

Does Endometriosis Cause Infertility? By Özge Özkaya

Infertility may be related to the localization of endometriosis involvement according to a study published in the Journal of Obstetrics and Gynaecology. This finding is in agreement with the results of previous studies and could help clinicians in their decision…

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Another Marker to Predict the Outcome of IVF for Women with Endometriosis

Another Marker to Predict the Outcome of IVF for Women with Endometriosis By Özge Özkaya

AOPPs or advanced oxidative protein products may be new markers to predict egg quality and the outcomes of IVF in infertile women with endometriosis according to a study published in the journal Experimental and Therapeutic Medicine. This finding suggests that anti-oxidative treatments…

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Can Getting Pregnant Make my Pain Go Away?

Can Getting Pregnant Make my Pain Go Away? By Özge Özkaya

The association between pregnancy and symptoms of endometriosis are controversial and strongly biased, and there is no evidence suggesting that pregnancy reduces the size and number of endometriotic lesions, according to a study published in the journal Human Reproduction Update.…

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Elevated Neutrophil Traps in Deep Infiltrating Endometriosis

Elevated Neutrophil Traps in Deep Infiltrating Endometriosis By Yu Yu

Neutrophils are a part of the innate immune system and act as a first-line host defense system by phagocytosis, intracellular killing and more recently describes mechanism involving extracellular killing by means of neutrophil extracellular traps (NETs). These traps are defined…

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Which cell defines endometriosis?

Which cell defines endometriosis? By Murat Osman

A well-accepted theory regarding the pathogenesis of endometriosis hypothesizes that the origin of endometriosis is from peritoneal dissemination of endometrial cells and stroma during the neonatal period or menarche. Varying cellular components of endometriosis have been observed in the setting…

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Endometriosis Not a Risk for Pregnancy

Endometriosis Not a Risk for Pregnancy By Özge Özkaya

Women with endometriosis do not seem to be more at risk of having pregnancy-related complications compared to those without endometriosis, according to a study published in the Italian scientific journal Minerva Ginecologica. However, the authors say that larger studies are…

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Should Women with Endometriosis have IVF Treatment to Conceive Following Laparoscopic Surgery?

Should Women with Endometriosis have IVF Treatment to Conceive Following Laparoscopic Surgery? By Özge Özkaya

Women affected by endometriosis-associated infertility who are younger than 35, and have a good ovarian reserve and a partner with normal semen parameters can benefit from a so-called integrated approach for the management of their infertility, according to a study published…

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Changes in Complement Proteins Affect Infertility in Women with Endometriosis

Changes in Complement Proteins Affect Infertility in Women with Endometriosis By Kasthuri Nair

Palomino et al. recently published a paper titled “The endometria of women with endometriosis exhibit dysfunctional expression of complement regulatory proteins during the mid-secretory phase” in the Journal of Reproductive Immunology where they look at the expression of CRPs during the menstrual cycle of…

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EFA Medical Conference 2017: "Fertility Preservation to BRCA Mutations" Presentation by Dr. Kutluk Oktay

EFA Medical Conference 2017: By Kasthuri Nair

Dr. Kutluk Oktay is the Director of the Laboratory of Molecular Reproduction & Fertility Preservation as well as a Professor of OBGYN at Yale University School of Medicine. Dr. Oktay also presented at the EFA 2017 Medical Conference, and his…

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Surgical treatment is an excellent option for women with endometriosis and infertility.

Surgical treatment is an excellent option for women with endometriosis and infertility. By Murat Osman

Women with endometriosis most often have difficulty becoming pregnant and thus require a combination of endometriosis treatment and infertility techniques to achieve pregnancy. Depending on the severity of endometriotic symptoms, women may or may not need surgical excision of endometriosis…

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Treatment of minimal endometriosis in infertile women

Treatment of minimal endometriosis in infertile women By Demet Candaş Green

For women with mild/minimal endometriosis, European Society of Human Reproduction and Embryology (ESHRE) recommends the removal of endometriotic lesions to improve fertility and increase pregnancy rates. For women undergoing assisted reproductive treatment, there is ongoing debate whether surgical removal of…

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EFA.MC.2017.“The Abnormal Embryos That Aren’t”,“Tens of thousands of women thought they couldn't have babies: But what if they could.”Dr. Norbert Gleicher Dr. Monica Halem

EFA.MC.2017.“The Abnormal Embryos That Aren’t”,“Tens of thousands of women thought they couldn't have babies: But what if they could.”Dr. Norbert Gleicher Dr. Monica Halem By Özge Özkaya

The presentation started with the story of Monica Halem who had endometriosis and had been trying to conceive using in vitro fertilization VF), but was told that none of her fertilized embryos would be viable based on pre-implantation genetic screening…

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Women with Mild Endometriosis May Have a Higher Risk of Miscarriage

Women with Mild Endometriosis May Have a Higher Risk of Miscarriage By Özge Özkaya

Mild endometriosis presents an increased risk of miscarriage according to a new study published in the scientific journal Fertility and Sterility.  Researchers think that this may be because superficial lesions are associated with a greater extent of the inflammatory disorder, which may lead…

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Role of immune cells in endometriosis

Role of immune cells in endometriosis By Demet Candaş Green

Immune cells have essential functions in the body such as detection and clearance of abnormal cells and debris. One of the possible mechanisms for the development of endometriosis is proposed to be the impaired function of immune system cells in…

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Is operation the best option for infertile patients with digestive endometriosis?

Is operation the best option for infertile patients with digestive endometriosis? By Demet Candaş Green

A severe form of endometriosis affecting 8-12% of women with deep endometriosis is bowel endometriosis. Bowel involvement with associated infertility is a serious challenge for gynecologists who must choose between two main therapeutic options: surgery or medically assisted procreation (e.g.…

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Swimming Against the Stream: Is Surgery Worthwhile in Women with Deep Infiltrating Endometriosis and Pregnancy Intention?

Swimming Against the Stream: Is Surgery Worthwhile in Women with Deep Infiltrating Endometriosis and Pregnancy Intention? By Murat Osman

Management of Deeply Infiltrating Endometriosis (DIE) is further complicated by the implications of affected patients who plan to become or are pregnant. Optimal management in this situation is not standardized due to a lack of randomized trials comparing primary surgery…

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The Endometriosis Fertility index Could Help Better Predict the Chance of Conceiving After Laparoscopy

The Endometriosis Fertility index Could Help Better Predict the Chance of Conceiving After Laparoscopy By Özge Özkaya

The endometriosis fertility index (EFI) can more reliably predict the chance of a woman getting pregnant following endometriosis surgery compared to the revised-American Society of Reproductive Medicine score, according to a study published in the scientific journal Gynecologic and Obstetric…

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Ovarian Reserve Depletion is not Time Sensitive

Ovarian Reserve Depletion is not Time Sensitive By Kasthuri Nair

The European Journal of Obstetrics & Gynecology and Reproductive Biology recently published a paper titled “Is endometrioma-associated damage to ovarian reserve progressive? Insights from IVF cycles.” This publication by Benaglia et al. examines the controversial relationship between endometriosis and ovarian…

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Single Nucleotide Polymorphisms Play a Role in Endometriosis Related Infertility

Single Nucleotide Polymorphisms Play a Role in Endometriosis Related Infertility By Kasthuri Nair

In their paper titled “Endometriosis-associated infertility: GDF-9, AMH, AMHR2 genes polymorphisms,” De Conto et al. attempt to elucidate the mechanism that leads to endometriosis-related infertility. In short, the authors hypothesize that there is a connection between polymorphisms in the Growth…

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Endometriosis and Psychological Health: Butterflies from Deep Wounds

Endometriosis and Psychological Health: Butterflies from Deep Wounds By Kasthuri Nair

Endometriosis is a grueling disease in every sense of the word; however, most of the discussions center on the physical manifestations of the disease. Facchin et al. veer from the beaten path and examine the impact endometriosis have on a…

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Updates in the Field of Endometriosis: Surgery

Updates in the Field of Endometriosis: Surgery By Kasthuri Nair

Surgery is one of the treatment options offered for individuals with endometriosis. With that in mind, there are a variety of surgical procedures that can be offered to an individual with endometriosis. In the chapter titled “Surgery and Endometriosis,” Zanelotti…

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Updates in the Field of Endometriosis: Fertility

Updates in the Field of Endometriosis: Fertility By Kasthuri Nair

Infertility can be a significant problem for many women who are suffering from endometriosis. In their chapter titled “Endometriosis and Fertility,” Evans and Decherney discuss the role of endometriosis in infertility and examine the usefulness of various fertility treatments. The…

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Updates in the Field of Endometriosis: Fertility Preservation

Updates in the Field of Endometriosis: Fertility Preservation By Kasthuri Nair

“Endometriosis and Fertility” is a chapter dedicated to examining the role of endometriosis and endometriomas in decreasing fertility. In other words, the authors of this chapter discuss the relationship between endometriomas, surgeries, and infertility. Barnett, Banks and Decherney also deliberate…

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Best Time for IVF Between 7 and 25 Months Post Surgery Study Suggests

Best Time for IVF Between 7 and 25 Months Post Surgery Study Suggests By Özge Özkaya

The more severe endometriosis is, the lower the success rate of IVF, according to a new study published in the Journal of Minimally Invasive Gynecology. However, the presence of endometriosis as such does not seem to affect the outcome of…

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A Systematic Review of Guidelines for Diagnosis and Management of Endometriosis

A Systematic Review of Guidelines for Diagnosis and Management of Endometriosis By Yu Yu

Guidelines are systematically developed statements derived from best research evidence to improve patient care through informed clinical practice. Appropriate guidelines can reduce unwarranted variations health practice and the implementation of better interventions. Endometriosis commonly has three different manifestations, including peritoneal…

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First-line surgery followed by ART versus ART alone among women with colon-involving endometriosis.

First-line surgery followed by ART versus ART alone among women with colon-involving endometriosis. By Murat Osman

Endometriosis, a disease characterized by the presence of endometrial tissue outside the uterus, may cause pelvic and gynecologic complications that affect fertility in women of reproductive age. Several forms of endometriosis have been observed that are characterized by the varying…

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Women with Deep Infiltrating Endometriosis Have a Higher Risk of Appendix Involvement

Women with Deep Infiltrating Endometriosis Have a Higher Risk of Appendix Involvement By Özge Özkaya

Women with deep-infiltrating endometriosis, a form of endometriosis that invades the abdominal and pelvic cavity, have an increased risk of developing endometriosis of the appendix. It is therefore important to check women with deep infiltrating endometriosis for appendix involvement during…

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Endometrial Receptivity and Infertility

Endometrial Receptivity and Infertility By Kasthuri Nair

A study entitled “Endometrial receptivity in eutopic endometrium in patients with endometriosis: it is not affected, and let me show you why” was recently published in Fertility and Sterility explored the relationship between endometriosis and infertility. This study conducted by Miravet-Valenciano et al.…

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How ERα is regulated in endometriosis?

How ERα is regulated in endometriosis? By Yu Yu

Endometriosis pathogenesis is largely influenced by estrogen. Ectopic endometrium has altered expression of ERα compared to the eutopic endometrium. It is unclear what biological processes regulate such alteration. The article by Toderow et al. in Archives of Gynecology and Obstetrics…

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Immune substances in peritoneal fluid for endometriosis diagnosis and armamentarium

Immune substances in peritoneal fluid for endometriosis diagnosis and armamentarium By Yu Yu

Cytokines are immune substances secreted by a broad range of cells within the body, including immune cells like the macrophages, B lymphocytes, T lymphocytes, mast cells, and non-immune cells such as the endothelial cells and fibroblasts. They are important in…

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