By Selma OransayClinical Endometriosis Despite Negative Histology: A Diagnostic Dilemma
By Selma Oransay
To diagnose endometriosis, clinicians typically rely on a combination of symptoms, noninvasive imaging, and histopathological examination of lesions seen during surgery. However, in some cases, even when visible lesions suggest endometriosis, histological confirmation is not obtained—leaving the diagnosis uncertain. This…
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Psychological and Clinical Impact of Adolescent Endometriosis
By Selma Oransay
Alarmingly, two-thirds of individuals with endometriosis report symptom onset before the age of 20, underscoring the importance of timely recognition and intervention for adolescent endometriosis. In adolescent age group, severe menstrual pain is the most common symptom, often interfering with…
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Endometriosis-Related Infertility: Focus on Oocyte Quality
By Selma Oransay
Fertility and pregnancy success depend on three key factors: the number of oocytes, ovulation, and oocyte quality. While tests such as anti-Müllerian hormone levels and antral follicle counts can estimate oocyte quantity and ovulation, oocyte quality can only be assessed…
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Physical Activity Boosts Self-Perception in Young Women with Endometriosis
By Selma Oransay
Endometriosis affects millions of women worldwide, causing chronic pelvic pain, infertility, and significant disruptions to daily life. Beyond the physical pain, this condition can severely impact a woman’s self-esteem and body image. Since body perception is closely tied to physical…
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By Özge ÖzkayaPain Catastrophizing Associated With Pain Disability in Endometeiosis
By Özge Özkaya
Pain catastrophizing and pain disability significantly affect each other in patients with endometriosis, according to a new study published in the Journal of Obstetrics and Gynaecology Canada. “Future research should examine the temporal relationship between catastrophizing and disability to inform…
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The current management of endometriosis-related infertility.
By Selma Oransay
Endometriosis is a chronic disease affecting women of reproductive age, often presenting with pelvic pain such as dyspareunia, dyschezia, and dysuria, or inertility, and significantly impacting quality of life. Management should be individualized based on symptoms, reproductive goals, age,…
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Imaging findings in postmenopausal endometriosis
By Selma Oransay
Most women diagnosed with endometriosis during their reproductive years become asymptomatic in postmenopausal period, but lesions remain biologically active despite lower estrogen levels. The pathophysiology of postmenopausal endometriosis remains unclear, though lesions appear less active and extensive. The risk of…
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Endometriosis in Adolescents: Diagnosis, Treatment, and Challenges
By Selma Oransay
Endometriosis is a condition that affects not only adult women but also adolescents, regardless of their race, ethnicity, or socioeconomic status. It can cause significant pain, including dysmenorrhea and pelvic pain. Research has shown that up to 20% of transgender…
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Adenomyosis as a Barrier to Effective Surgery for Dyspareunia in Rectovaginal Endometriosis
By Selma Oransay
Women with endometriosis often experience severe pain during intercourse, known as dyspareunia, which can deeply affect their quality of life and intimate relationships. One form of this condition, rectovaginal septum endometriosis, involves deep, scarred tissue that can cause pain during…
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Knowledge synthesis of the "Relevance of Endometriosis Diagnostic Tools"
By Selma Oransay
Spiers et al. from the Department of Obstetrics and Reproductive Medicine at Angers University Hospital in France identified significant diagnostic challenges and the absence of definitive diagnostic tools for endometriosis. In response, they evaluated existing medical literature to enhance diagnostic…
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An observational study on predicting endometriosis recurrence risk.
By Selma Oransay
Endometriosis presents in various ways, and improper management can lead to recurrence. Studies show that the recurrence rate can range from 6% to 67%. Factors that may increase this risk include having severe or deep forms of the disease, being…
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Bladder Endometriosis: Current Knowledge and Future Directions
By Selma Oransay
About 70-80% of urinary tract endometriosis occurs in the bladder, particularly affecting the base and dome regions. Endometriotic lesions can penetrate the detrusor muscle either partially or completely. Endometriosis affecting the uterovesical fold peritoneum or deep endometriosis that does not involve…
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By Hale Goksever CelikLaparoscopic procedures can alleviate fatigue in women suffering from endometriosis
By Hale Goksever Celik
The most common symptoms of endometriosis include pelvic pain, dysmenorrhea, dyspareunia, and infertility. Effective management is essential due to the significant impact these symptoms have on a woman's quality of life. Fatigue, characterized by persistent and severe tiredness, is also…
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Superiority of hysterectomy over lesion excision in the treatment of rectovaginal endometriosis
By Selma Oransay
Confirmative treatment of endometriosis includes excision or ablation of visible lesions while conserving the uterus and ovaries. On the contrary, the radical approach involves total hysterectomy and even bilateral oophorectomy to create a hypo-estrogen state, remove adenomyosis if it exists,…
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Effect of Endometriosis Pain in Women Living in Similar Socio-Economic Conditions
By Özge Özkaya
Endometriosis-associated pelvic pain is associated with reduced health-related quality of life including impaired mental and sexual functioning among women in France, Germany, Italy, Spain, the UK, and the US, according to a new study published in the Journal of Minimally Invasive…
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A literature review about postmenopausal endometriosis.
By Selma Oransay
Typically, endometriosis disease brings relief to women after menopause, but some individuals continue to develop some endometriosis-related issues even after the cessation of menstruation. This enigmatic condition, called postmenopausal endometriosis, needs to be understood, and the disease must be diagnosed…
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Endometriosis and musculoskeletal function of pelvic loin complex
By Hale Goksever Celik
Endometriosis is an inflammatory and estrogen-dependent disease which is diagnosed in reproductive-aged women most frequently. These women present with a broad clinical spectrum including pelvic pain, dysmenorrhea, dyspareunia and infertility. All of these symptoms and signs may harm women’s lives…
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Diminished physical activity in women with endometriosis due to chronic pelvic pain
By Hale Goksever Celik
Endometriosis is a systemic, chronic, inflammatory disease defined as the localization of endometrial-like tissue outside the uterine cavity. Pelvic pain is the most common symptom in these women resulting in abstinence from school or work and psychosocial problems. Physical activity…
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By Eylül GÜNChronic pelvic pain mechanisms in endometriosis
By Eylül GÜN
M. J. Quinn from Shanghai, China wrote an editorial piece in the latest issue of the American Journal of Obstetrics & Gynecology commenting on an article by Gete et al. in which they shared the findings from the Australian Longitudinal Study…
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A concerning link between endometriosis and cardiovascular disease.
By Selma Oransay
Endometriosis is a disease characterized by endometrial-like tissues outside the uterus, which causes inflammation, scarring, and adhesion formation. The pathologic process of forming those adhesions releases proinflammatory molecules, cytokines, and growth factors that may have systemic effects. Recent research, for…
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By Nasuhi Engin AydinA comprehensive review of subdermal progestin in adenomyosis management
By Nasuhi Engin Aydin
French academicians from Lyon and Marseilles led by Dr. Chene have published recently an electronic database search on the effectiveness of progestin subdermal implants in adenomyosis patients. This review appeared in the March 2024 issue of “The European Journal of…
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Uterine innervation and its impact on endometriosis related pelvic pain.
By Selma Oransay
Advancements in immunochemistry, fluorochromes, computer-associated anatomical dissection, and 3D reconstruction of uterine micro-innervation brought substantial progress in pelvic neuroanatomy. The complex uterine innervation and its interactions with uterine parts and layers are yet fully revealed. Austruc et al., from the…
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Ultrasonographic findings and the clinical symptoms of pelvic endometriosis
By Selma Oransay
Imaging techniques achieve the clinical diagnosis of endometriosis, which affects 10-15% of all women of reproductive age. Suspected patients with clinical history and symptoms need a systemic examination of the uterus, ovaries, adnexa, and peritoneal covering the rectouterine, retrocervical, and…
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Visual representation of endometriosis pain
By Selma Oransay
Endometriosis is accompanied by severe chronic pelvic pain that impacts quality of life, relationships, and work conditions. Studies aiming to improve pain are frequently encountered in the literature. Nonetheless, pain research is complex due to its subjective nature, and cannot…
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Postoperative pain-related quality of life for patiens with different types of endometriosis surgery.
By Selma Oransay
Endometriosis surgery usually improves chronic pelvic pain and the quality of life in women suffering from that disease. Response to surgery depends on several factors, however, in younger ages, recurrence of both pain and endometriosis lesions are reported. Most research…
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Early diagnosis of deep infiltrating endometriosis in adolescence
By Selma Oransay
Dysmenorrhea is widely observed in adolescence, and endometriosis is one of its causes. However, endometriosis diagnosis is usually made after 25 years of age. It is clear that early diagnosis and management of this progressive disease is essential and will…
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Psychological effect of endometriosis due to chronic pelvic pain
By Hale Goksever Celik
The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, and chronic pelvic pain, all of which affect the quality of women’s lives. Early diagnosis and management are important as endometriosis impairs the quality of life of patients and creates a…
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Can We Reliably Measure Sleep Quality in Women With Endometriosis?
By Özge Özkaya
The Insomnia Severity Index (ISI) and the Pittsburgh Sleep Quality Index (PSQI) lead to consistent scores comparable in women with deep infiltrating endometriosis, according to a new study published in the scientific journal Sleep Medicine. However, the cutoff values of…
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Psychosocial Factors Must Be Taken Into Account When Dealing With Endometriosis
By Özge Özkaya
It is crucial to take into account both physical and psychosocial factors to maintain physical and mental health in patients with endometriosis, according to a new study published in the scientific journal Psychology & Health. “Treatment should address both pelvic…
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Complementary and alternative therapies for managing acyclic pelvic pain in women with endometriosis
By Hale Goksever Celik
The quality of life in women with endometriosis is affected depending on the symptoms and signs of endometriosis such as dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Because of different clinical spectrum and diagnostic delays, there is no optimum management…
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"Ovarian Reserve Markers" in Peritoneal Endometriosis
By Selma Oransay
Endometriosis-related subfertility is attributed to multiple factors, including mechanical obstructions, adhesions, pelvic inflammation, and diminished ovarian reserve. Serum anti-Mullerian hormone (AMH) levels and ovarian antral follicle counts (AFC) currently serve as fertility markers to diagnose decreased ovarian reserve and failure.…
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Coupled torture due to endometriosis and depressive symptoms
By Eylül GÜN
Endometriosis significantly impacts various aspects of women's lives including their physical and mental health, careers, and social relationships. Physically, it causes chronic pelvic pain and dyspareunia, affecting 5-10% of reproductive-age women and leading to infertility challenges and a substantial percentage…
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Diagnosis and the Treatment of Postmenopausal Endometriosis
By Selma Oransay
About 190 million women around the world are diagnosed with endometriosis. The majority of the cases are between 30 and 40 years of age. After menopause, the incidence of endometriosis declines to 2-5%, and it is more common in women…
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Potential New Therapeutic Avenue for Deep Endometriosis
By Özge Özkaya
The use of lipid nanoparticles carrying methotrexate seems to be safe and feasible in women with deep infiltrating endometriosis, according to a new study published in the scientific journal Archives of Gynecology and Obstetrics. The approach could, therefore, be a new…
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A non-invasive test to determine the risk of endometriosis in women having chronic pelvic pain or unexplained infertility
By Hale Goksever Celik
Women having endometriosis may suffer from chronic pelvic pain and/or infertility, both of which diminish the quality of life in these women. Minimalization of the time between the onset of symptoms and diagnosis is essential to improve patients’ lives. However,…
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Mediterranean Diet Associated With Less Endometriosis Pain?
By Özge Özkaya
There seems to be a link between pain relief in endometriosis and a Mediterranean diet, according to a new study published in the International Journal of Science. This finding suggests that a Mediterranean diet could help manage chronic pain in…
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Sacral neuromodulation for endometriosis-related chronic pelvic pain
By Selma Oransay
Sacral neuromodulation is a therapeutic technique that involves electrical stimulation of a sacral nerve route to modulate a neural pathway. The device is an implantable neurostimulator, and the procedure is a minimally invasive procedure with good long-term outcomes. This technique…
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The overlap of endometriosis and polycystic ovarian syndrome
By Eylül GÜN
Polycystic ovarian syndrome (PCOS) is one of the most common causes of female subfertility similar to endometriosis. It has been hypothesized that owing to the underlying pathophysiological mechanisms, women with endometriosis are at a greater risk of having PCOS than…
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Comparison of two different surgical approach to deep colorectal endometriosis in terms of postoperative outcomes.
By Selma Oransay
Deep colorectal endometriosis affects one-fifth of women with endometriosis, which is commonly associated with more pelvic pain and severe gastrointestinal symptoms. Three surgical approaches for deep colorectal endometriosis are segmental colorectal resection, full-thickness discoid resection, and shaving operation. Choosing the…
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Peritoneal Endometriosis and Acyclical pelvic pain
By Eylül GÜN
The most debilitating symptom of endometriosis is chronic pelvic pain. The peripheral nervous system is affected and the growth and regeneration of sensory nerve fibers in endometriotic tissue has been identified. The first line treatment which is hormonal therapy for…
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Exploring endometriosis symptoms and their effects on women's lives
By Eylül GÜN
Endometriosis symptoms, their severity, and the way they affect patients' lives may vary. With the aim of investigating different personal experiences and perceptions of endometriosis symptoms and the way they impact women's daily lives, Hunsche and colleagues from Switzerland and…
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The compliance for post-surgical follow-ups after endometriosis surgery
By Selma Oransay
. The patient's adherence to follow-ups after surgery is essential as it is the only way to evaluate the surgery's benefits in improving pain symptoms and recurrences, measuring the quality of life, and fertility outcomes. . Dr. Szabo and his…
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Objective Assessment of Pain Sensitization in Women With Chronic Pelvic Pain
By Özge Özkaya
There are objective elements that can help assess the presence of central sensitization, independently of psychological factors, according to a new study published in the American Journal of Obstetrics and Gynecology. This is the first study that assessed whether central sensitization…
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Pain Scoring System for Deep Endometriosis
By Selma Oransay
The numeric pain scale is commonly used to interpret pain score values. According to the National Comprehensive Cancer Network guidelines, pain scores of 4-7 points indicate moderate, and 8-10 points indicate severe pain. Patients with a local pain score of…
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Outcomes of improving chronic pelvic pain with "immersive digital therapeutics" at home.
By Selma Oransay
Studies have shown that virtual reality can effectively treat acute pain experienced by burn victims, during labor, dental surgery, or for chronic musculoskeletal, neuropathic, and cancer pain. Considering the effectiveness of treating chronic pelvic pain at home, Merlot et al.…
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Outcomes of chronic pelvic pain after niche repair
By Selma Oransay
Rapidly increasing cesarian section rates in recent years increased the cesarian scar defects and the development of "isthmoceles". Isthmocele is a myometrial lesion located around the isthmic portion of the uterus that is a myometrial discontinuity or hypoechoic triangle in…
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Limitations of current surgical classification systems for endometriosis.
By Selma Oransay
Many classification systems for endometriosis have been developed since the 1970s, and in a 2021 review, more than 20 of those systems were identified. The best-known and most frequently used are rASRM (revised American Society of Reproductive Medicine), the Enzian…
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Pelvic pain in transgender individuals on testosterone therapy
By Eylül GÜN
Pelvic pain is a common issue among individuals assigned female at birth who are transgender or gender diverse (referred to as trans individuals) and are undergoing testosterone therapy as part of their gender-affirming hormone treatment. However, this topic remains poorly…
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The cost-effectiveness of different GnRH agonist regimes for progestogen-resistant endometriosis.
By Selma Oransay
Surgical and medical treatments are currently used to treat the pelvic pain caused by endometriosis. Respected guidelines recommend using progestins with or without estrogens as first-line medical treatment due to their safety, effectiveness, inexpensive, and tolerability. However, one-third to one-quarter…
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Integrative medical management of endometriosis
By Selma Oransay
This lecture entitled "Integrative Medical Management of Endometriosis" was presented by Dr. Pinar Kodaman, Director of the endoscopic reproductive surgery program and Assoc. Professor of Clinical ObGyn and Reproductive Sciences at the Yale School of Medicine. In addition to surgery which…
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Which surgery for deep endometriosis? Laparoscopic shaving or rectal resection?
By Selma Oransay
This keynote lecture entitled "Deep endometriosis: The place of laparoscopic shaving" was presented by Dr. Jacques Donnez, the director of the infertility research unit at the Catholic University of Louvain, Brussels, Belgium, at the Annual International Medical Conference of the Endometriosis Foundation…
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Is there any advantage of addition of hysterectomy on deep endometriotic pelvic pain or on the quality of life?
By Selma Oransay
The addition of hysterectomy and salpingo-oophorectomy to the endometriosis excision surgery provided greater benefits when compared to excision surgery alone, according to the results of a comparison study that was recently published in the journal named "Facts Views and Visions in Obstetrics…
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Women With Chronic Pelvic Pain Have a Negative Experience With Doctors
By Özge Özkaya
Women with chronic pelvic pain have a negative experience with the healthcare system, according to a study by US researchers published in the International Journal of Obstetrics and Gynecology. This is the case regardless of whether or not they have…
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GnRH Antagonists Can Effectively Reduce Endometriosis Pain
By Özge Özkaya
Oral gonadotropin-releasing hormone (GnRH) antagonists are effective in reducing pain associated with endometriosis in 12 weeks, according to a new study published in the scientific journal Archives of Gynecology and Obstetrics. The safety and efficacy of most drugs were dose-dependent…
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By Bahar YukselMyofascial pain management and endometriosis
By Bahar Yuksel
Endometriosis is an inflammatory disease that causes inflammation around pelvic muscles and peripheric nerves which ultimately may cause peripheral and central sensitization and result in increased response to pain. In the study conducted by Shrikhande at al. from the pelvic…
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The most common gynecologic admissions to the emergency: Endometriosis and adenomyosis
By Hale Goksever Celik
Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Adenomyosis occurs when the endometrial glandular and stromal tissue grows into the muscular wall of the uterus, called the myometrium. Women having adenomyosis also…
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Younger Women With Endometriosis Feel More Pain
By Özge Özkaya
Younger women with endometriosis feel more period pain (dysmenorrhea) and pain during intercourse (dyspareunia) compared to older women with the disease, found a new study published in the Journal of Pediatric and Adolescent Gynecology. Acknowledging this fact can make sure…
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The "Painful Periods Screening Tool" Could Speed Endometriosis Diagnosis
By Özge Özkaya
The Painful Periods Screening Tool (PPST) is a useful tool for women with endometriosis, according to a new study published in the scientific journal Reproductive Sciences. The study's authors said that the tool “ facilitated communication between patients and providers…
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Endometriosis and the body perception
By Hale Goksever Celik
The most common endometriosis-associated symptoms are pelvic pain, dysmenorrhea, dyspareunia, and infertility. Women with endometriosis should be managed due to the significant impact of these symptoms on their quality of life. Body perceptions of these women are also affected depending…
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Opioid use following operation for endometriosis or pelvic pain
By Hale Goksever Celik
Women with endometriosis have pain in the form of dysmenorrhea, dyspareunia, and chronic pelvic pain, and they have a diminished quality of life depending on the severity of pelvic pain. Opioids have been preferred in many patients suffering from pain,…
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What causes pelvic pain? Androgens or estrogens?
By Selma Oransay
A comparison between women and men reveals that women suffer more pelvic pain. This reality raises the possibility of the pain-relieving effect of testosterone or androgens. It would be a wise solution to investigate how androgens affect pain at different…
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Anhedonia and its relation to endometriosis as a sole symptom
By Eylül GÜN
"Anhedonia may be defined as a broad category of hedonic function deficiencies, including diminished motivation or enjoyment capacity. It has been an area of interest for a long time in psychiatric disorders and has been crucial in some diagnoses such…
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Non-hormonal medication for endometriosis-associated pelvic pain
By Selma Oransay
The thought of benefiting from non-hormonal therapy in endometriosis pain is based on the pathophysiological findings that include angiogenesis, fibrosis, the presence of inflammatory cytokines and immune cells, apoptosis, and stem cell theory. But the effect of this treatment in…
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Pelvic pain characteristics in young girls with endometriosis.
By Selma Oransay
The occurrence of severe and frequent pelvic pain in young women is a piece of evidence that endometriosis begins and develops at an early age. Two-thirds of women with endometriosis who were diagnosed in their adulthood reported the onset of…
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Endometriosis Prediction by "Machine Learning"
By Selma Oransay
To develop a predictive model for endometriosis and to re-assess the contribution of known risk factors, Blass et al. from the Hebrew University of Jerusalem, Jerusalem, Israel used the data of the UK biobank by machine learning-based models. They compared and…
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To Remove the Ovary(ies) or Not During Hysterectomy for Endometriosis
By Selma Oransay
Some surgeons prefer empiric bilateral salpingo-oophorectomy during the hysterectomy of women with endometriosis based on the knowledge that endometriosis is stimulated by endogenous estrogens, as leaving the ovaries in situ may increase the possibility of endometriosis recurrence and pelvic pain.…
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Chronic pelvic pain and endometriosis
By Selma Oransay
Patients may have an average of 7 clinical visits before being diagnosed with endometriosis. Understanding chronic pain conditions including endometriosis-associated pain, and developing chronic pelvic pain benefits the management of the patients. The role of central sensitization, comorbid conditions, and…
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Surgery Improves the Sex Life and Sleep of Women With Endometriosis
By Özge Özkaya
Endometriosis surgery improves patients’ quality of life, sexual function, and sleep confirms a new study by Turkish researchers published in the scientific journal Archives of Gynecology and Obstetrics. According to the first author Dr. Belfin Nur Arici Halici of the…
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The consequence of COVID-19 pandemic on endometriosis patients
By Selma Oransay
The relevant policies and restrictions concerning Covid-19 have prevented patients from accessing medical care. Similarly, standard care for endometriosis patients has also been negatively impacted by postponed or canceled appointments and suspended surgeries across the countries. Women trying to cope…
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Endometriosis diagnosis and management based on the best available evidence from published literature
By Selma Oransay
ESHRE, "European Society of Human Reproduction and Embryology" published a Guideline for the diagnosis and treatment of endometriosis in 2005 and then revised it in 2013. Based on new research and development there was a need to renew the last…
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It is all about awareness when it comes to endometriosis
By Bahar Yuksel
Endometriosis and chronic pelvic pain are known to have debilitating effects on daily life, educational life, and work life. However, the true prevalence and effects of the disease data are still controversial all over the World. The survey-based study conducted…
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Quality of life assessment in women with endometrioma
By Eylül GÜN
Like most chronic diseases, endometriosis poses a significant risk of diminishing the quality of life in patients suffering from it, particularly with its most considerable symptom; chronic pelvic pain. Although it is known that endometriosis is more common in East…
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Physical activity and exercise in reducing endometriosis symptoms
By Eylül GÜN
The treatment modalities to date on endometriosis have focused on the symptomatic relief and management of chronic pain. Hormonal suppression sometimes shows intolerable side effects and is known to lose effect after some time. Surgical interventions may not provide a…
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Pain alone is not a specific predictor for endometriosis diagnosis
By Hale Goksever Celik
The most common symptoms and signs of women with endometriosis include dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. However, diagnostic delay still occurs due to the broad clinical spectrum of the disease and the absence of non-invasive diagnostic biomarkers. Gordon et…
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From Spain: execution for endometriosis and chronic pelvic pain unresponsive to conventional therapies
By Selma Oransay
The current conventional therapy for chronic pelvic pain for endometriosis is defined as either hormonal or non-hormonal medical treatment starting with combined oral contraceptives progestins or dienogest, and then gonadotropin-releasing hormone analogs and/or surgery. Although conventional therapies usually are successful, still…
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An Overview on Treatment of endometriosis
By Selma Oransay
There are different guidelines by different gynecological societies for the diagnosis and treatment of endometriosis, which is an extremely complex illness. Kalaitzopoulos and Samartzis et al. from Switzerland worked on and compared six national and two international widely used guidelines to…
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Effects of Hormonal Contraceptives on Endometriosis Pain
By Özge Özkaya
There is no difference between the oral progestin dienogest and combined oral contraceptive pills in managing pain and increasing quality of life in women with endometriosis, according to the results of a randomized, double-blind, placebo-controlled clinical trial. However, there was…
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Relationship Goals and Sexual Satisfaction for Couples Coping with Endometriosis
By Selma Oransay
"Relationship satisfaction" is based on an individual's emotional judgment. Physical and emotional obstacles may present and negatively affect relationship satisfaction. Endometriosis is associated with multiple life domains, and also includes relationship and sexual satisfaction. Sexual satisfaction, on the other hand,…
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Cross-cultural translation and adaptation of an endometriosis survey
By Eylül GÜN
Endometriosis is a disease that presents heterogeneously which makes it hard to identify a causal relationship. A patient-based questionnaire called Endometriosis Participant Questionnaire (EPQ) has been originated by The World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project. It…
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The new Endometriosis Surgical Complexity Classification: AAGL 2021
By Selma Oransay
Multiple endometriosis categorizations have been approved in the recent forty years. The American Fertility Society proposed ASRM with a desire to score the impact of the endometriosis in 1996, which was updated several times later (rASRM), to predict infertility after laparoscopic operations. For…
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Could Cannabis Be Recommended to Manage Endometriosis?
By Özge Özkaya
It is not possible to recommend cannabis-based products to patients with endometriosis because there is not enough evidence supporting their benefits, according to a new study published in the Journal of Minimally Invasive Gynecology. Cannabis-based products have been suggested as…
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Persistence of Chronic Pelvic Pain after Hysterectomy
By Hale Goksever Celik
Chronic pelvic pain is defined as the "pain in the pelvic area that lasts for 6 months or longer". There are several gynecological, urological, and gastrointestinal reasons for the development of chronic pelvic pain. Nociceptive pain or central sensitization is…
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The Cost of Healthcare for Chronic Pelvic Pain
By Özge Özkaya
The healthcare costs of pelvic pain range between 1,367 USD and 7,043 USD per woman per year, found a new study published in the Journal of Obstetrics and Gynaecology Canada. The study also reported that prescription costs ranged between 193…
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By Dr. Youngran ParkAwareness is the first step toward endometriosis treatment
By Dr. Youngran Park
We want to reiterate the importance of endometriosis, by handling the paper entitled "Endometriosis awareness: screaming at the top of our voices" published on April 2021 in the journal “Women & Health”. The Endometriosis Awareness Month of 2021 was a little different,…
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Outpatient neuromuscular protocol may improve the quality of life in women with chronic pelvic pain
By Bahar Yuksel
Chronic pelvic pain syndrome is a complicated entity causing central and peripheric sensitization of nerves. The sensitization processes start a loop of unbreakable pain chain causing resistance to conventional therapy methods. The study conducted by Soha Patil et al covering data…
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Depression and Anxiety Common in Women with Endo
By Özge Özkaya
Symptoms of depression and anxiety are frequent among women with endometriosis and are related to chronic pain, confirms a review of the literature and meta-analysis published in the Journal of Women's Health. According to the study authors, correlating factors should…
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The incidence and prevalence of endometriosis in a United States population-based study .
By Selma Oransay
To define the accurate incidence and prevalence estimates of endometriosis among nonselected cohorts in the USA, Christ et al. from the Departments of Obstetrics and Gynecology of the University of Washington, Seattle, planned a retrospective cohort study using the electronic KPWA…
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Non-pharmacological self-care: dietary modifications in women with endometriosis.
By Selma Oransay
The academic interest on the role of diet in endometriosis has grown due to its possible relation with inflammation, estrogenic activity, and menstrual cycles. Multiple dietary strategies and prescriptions are being used to deal with the pelvic pain and gastrointestinal…
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Impact of adenomyosis on sexual life
By Selma Oransay
Considering the similar etiopathogenesis and pain symptoms between adenomyosis and deep infiltrating endometriosis, Alcalde et al. from the Department of Gynecology, University of Barcelona, Spain, aimed to call attention to the presence of potential sexual dysfunction not only in patients with deep…
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The Severity of Pain Does not Predict Endometriosis or its Stage, Study Confirms
By Özge Özkaya
The intensity of pain a woman experiences could predict whether or not she would undergo laparoscopic surgery. However, it could not predict whether she has endometriosis or in case she did, the severity of her disease. This is according to…
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Outcomes of chronic pelvic pain of endometriosis after laparoscopic surgery
By Selma Oransay
The prevalence of endometriosis is up to 35-50% among patients with pelvic pain. Among several medical and surgical options to relieve chronic pelvic pain, surgical options are the preferred method but this depends on patients' age, fertility desire, and disease…
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Managing Persistent Pelvic Pain in a distinct "pain" clinic
By Selma Oransay
Persistent pelvic pain is an important problem producing physiological stress and productivity loss during the reproductive period of women. A specific pelvic pain clinic named "Mater Health Persistent Pelvic Pain Clinic" was established in 2017 in a part of the emergency…
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Peritoneal Pockets and Endometriosis
By Özge Özkaya
Infertile women with peritoneal pockets had more endometriosis compared to women without pockets according to a study published in the Journal of Obstetrics and Gynaecology Canada. Severe pelvic pain was also associated with the presence of pockets and the presence…
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Endometriosis and Sexual Satisfaction
By Özge Özkaya
Endometriosis affects the ability to have an orgasm during sexual intercourse, according to a study published in The Journal of Sexual Medicine. However, the disease does not have an effect on reaching orgasm via masturbation or sexual activities with a…
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The incidence of endometriosis and pelvic pain in transgender man
By Bahar Yuksel
Transgender operations are quite common all around the world and hysterectomies are performed almost 1 in 5 of this population. The studies conducted until now mostly evaluated operative and postoperative outcomes, but the present research also questioned the preoperative symptoms and…
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The improvement of fertility rate and symptoms of superficial endometriosis following laparoscopic peritoneal stripping
By Selma Oransay
Pain, in the form of diverse entities, including dyspareunia, dysuria, dyschezia, is the main symptom of endometriosis patients. The severity of pain is independent of the extent and the location of the disease, and generally causes a negative impact on…
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Vitamin D supplementation, endometriosis symptoms and metabolic profiles
By Hale Goksever Celik
Patients with endometriosis suffer from dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. These women are also at higher risk for ovarian and breast cancer, cardiovascular events, and metabolic abnormalities. Several medical and surgical alternatives have been recommended to these patients…
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Exploring the Role of Neuropathy in Re-Operative Endometriosis - Marc Possover, MD, PhD
By Özge Özkaya
Prof. Possover starts his presentation by summarizing the possible cause of pelvic neuropathy following endometriosis surgery. Pelvic neuropathy is the damage or dysfunction of the pelvic nerve. Prof. Possover explained that this could either be due to incomplete surgery, disease…
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By Irem OnurExploring Pelvic Pain: Deep to Ischial Spine Including Pre-Sacral Roots - A. Taner Usta, MD
By Irem Onur
Chronic pelvic pain is defined as pain in the pelvic area that lasts for 6 months or longer and results in functional or psychological disability or requires intervention and treatment by the American College of Obstetrics and Gynecologists. There are…
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Endometriosis and chronic opioid use
By Selma Oransay
The members of the American College of Obstetricians and Gynecologists have declared that gynecologists prescribe opioids after laparoscopic hysterectomy, or for relieving endometriosis pain, although guidelines are not available for when or how to use opioids for the treatment of endometriosis-associated…
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Pain in Endometriosis
By Dr. Youngran Park
Endometriosis is a chronic and debilitating condition characterized by chronic pelvic pain (CPP) and infertility. It affects approximately 10% of women globally and more than 60% of women diagnosed with endometriosis report CPP. However, the mechanisms underlying the associated pain…
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The peculiarity of adolescent endometriosis
By Selma Oransay
Recent studies showed the prevalence of endometriosis in adolescents with chronic cyclic or acyclic pelvic pain is about 60-70%. Moreover, all stages of endometriosis, including deeply infiltrating endometriosis can be found in this population. Gubbels et al. from the Department…
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The intensity of pelvic pain is higher in endometriosis patients
By Irem Onur
Silva J.B. et al., researchers from Brazil, conducted a case-control study to determine the intensity of clinical pain, the average body composition, and the anthropometric markers including the body mass index, the perimeters (waist, abdomen, hip), and the percentage of…
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By Ellen TumimbangPain and Quality of Life Following Surgical Treatment for Endometriosis
By Ellen Tumimbang
Currently, laparoscopy is the preferred approach as a surgical treatment of endometriosis. Many studies have shown the effectiveness of laparoscopic surgery to reduce the painful symptoms and improve the quality of life for patients with endometriosis in the short term…
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By Timur SeckinFactors affecting the quality of life of women with endometriosis
By Timur Seckin
Results from a new study suggest that the quality of life of women with endometriosis is significantly affected by their confidence to manage pain and their belief in the evolution of their condition. In this study, led by Rees M. et…
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Immune cells and endometriosis pain
By Dr. Youngran Park
Endometriosis is an estrogen-dependent inflammatory disorder in women. This disease leads to dysmenorrhea, pelvic pain, and infertility. The immune reaction is one of the most widely accepted pathologies of endometriosis. Estrogen dysfunction stimulates immune cells in the peritoneal cavity affecting…
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A New Treatment Approach for Endometriosis?
By Özge Özkaya
A new approach may be effective at relieving pain associated with endometriosis according to a study published in the PM&R Journal. The new technique may also improve “overall pelvic function, particularly in relation to intercourse, working, and sleeping,” according to the…
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Suggested remedies for endometriosis patients during coronavirus pandemic
By Nasuhi Engin Aydin
The pandemic of COVID-19 continues to have important effects on endometriosis patients worldwide. Many health care facilities stopped providing surgical management and outpatient appointments are canceled or postponed. Dr. Leonardi from Australia and associates from several countries published their proposals…
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Hysterectomy as a choise of chronic pelvic pain relief in endometriotic women.
By Selma Oransay
Sandstrom et al. from the Department of Obstetrics and Gynecology of Umea University, Sweden, found a significant and long-lasting reduction in pain symptoms after hysterectomy among women with confirmed endometriosis and recently published their results in "BJOG". The authors performed…
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Adolescent dysmenorrhea diagnosis and management
By Hale Goksever Celik
Endometriosis is usually diagnosed in reproductive-aged women. However, recent literature proved that clinical symptoms of endometriosis are also seen the adolescent girls and young women. Dysmenorrhea, the most common gynecologic complaint among this age group, can develop due to endometriosis.…
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The efficacy of combined hormonal contraception on pelvic pain in endometriosis patients
By Irem Onur
Chronic pelvic pain, which is experienced by more than 33% of endometriosis patients, constitutes a significant challenge for patients and physicians. A new study that appears in the journal Human Reproduction Open has explored the prevalence of endometriosis patients with a history…
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The Relationship Between Dyspareunia and Infertility in Endometriosis
By Selma Oransay
Wahl et al. from the Center of Pelvic Pain and Endometriosis British Columbia Women's Hospital, Vancouver, Canada studied with endometriotic patients suffering from dyspareunia who were referred to their center and built a cross-sectional study to investigate the relations between…
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When to do - and when not to do surgery for endometriosis
By Dr. Youngran Park
Endometriosis is an estrogen-dependent disorder. It was estimated to affect about 176 million women in the world and usually causes pelvic pain and infertility. Unfortunately, the current understanding of this disease is very limited. Though there are many remaining questions,…
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Surgery and the endometriosis associated-pain: A systematic review
By Selma Oransay
The surgical approach for pelvic pain-related to endometriosis depends on the stage and the type of the endometriotic lesion and ranging from ablation and the excision of the lesions to radical surgery as hysterectomy with removal of ovaries and presacral…
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Recurrent endometriosis is a real challenge both for the patients and clinicians
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Current medical and surgical treatment options have several limitations including the side effects, costs, risk of recurrence, effects on conception capability. Recurrence is a…
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Patients preferences for the treatment of endometriosis-associated pain
By Hale Goksever Celik
Endometriosis is defined as the location of endometrial stroma and glands outside the uterine cavity. The most common presenting complaints are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility, most of which relate to the menstrual period. Those women affected…
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By Murat OsmanEndometriosis that involves the nerves: how Radiologists can help
By Murat Osman
Endometriosis is a disease with variable clinical symptoms. While rare, nerve involvement by endometriosis may cause neurologic symptoms such as pelvic pain, muscle weakness, bowel and bladder incontinence, and paraplegia depending on the specific nerve involved. Thus, abdominal radiologists should…
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Chronic Fatigue Syndrome and Endometriosis: Comorbid Conditions
By Irem Onur
In the study of Dr. Boneva et al., from Atlanta, GA, the United States which has recently been published in the journal Frontiers in Pediatrics evaluated the impact of endometriosis on the health of women with chronic fatigue syndrome (CFS). The authors compared…
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Patients with Pelvic Pain Most Likely to Benefit from Endometriosis Surgery
By Özge Özkaya
Women who experience higher levels of pain are more likely to show improvement in their quality of life (QoL) following endometriosis surgery, according to a study published in The Journal of Minimally Invasive Gynecology. Chronic pelvic pain seems to be…
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The association of significant hemoperitoneum (blood in the abdominal cavity) and deep pelvic endometriosis
By Irem Onur
Although there are several theories to explain the etiology of deep endometriosis, the cause is unknown and there are currently no effective strategies to prevent its development. Bean E. et al., from University College London Hospital, UK, observed that some…
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Proposed algorithm for a clinical diagnosis of endometriosis.
By Selma Oransay
This recently published article in the American Journal of Obstetrics and Gynecology is about the challenge of diagnosing endometriosis, its impact on women's daily life and authored by Agarwal et al. from The University of California, San Diego, CA, USA. Authors called attention…
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Nutraceuticals may help for endometriosis pain
By Nasuhi Engin Aydin
Dysmenorrhea and chronic pelvic pain occur in endometriosis patients in a significant percentage. Anti-inflammatory medications and lifestyle changes including diet form the integrated approach in this regard. However, the medications can be used only for the short term. Natural substances with anti-inflammatory…
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Building an ultrasonographic database for superficial endometriosis.
By Selma Oransay
Chowdary et al. from University of Auckland, Australia, recently published a retrospective, small group study in Australian New Zeland Journal of Obstetrics and Gynecology, to demonstrate ultrasonographic findings of mild endometriosis patients with pelvic pain are associated with their laparoscopic diagnosis.…
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Assistive Reproduction a Suitable Option for the Treatment of Endometriosis-Associated Infertility
By Özge Özkaya
Assistive reproductive techniques do not lead to a worsening in quality of life and only cause a slight worsening of pelvic pain, according to a study published in the scientific journal Acta Obstetricia et Gynecologica Scandinavica. This is the case…
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Women with Persistent Pelvic Pain Have a Lower Pain Threshold
By Özge Özkaya
Women with persistent pelvic pain, whether this is caused by endometriosis or other reason, have a significantly reduced pain threshold compared to women without persistent pelvic pain. This is according to a study by researchers in Sweden, which was published…
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Endometriosis and female pelvic pain in all aspects
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence of the disease ranges between 6-10% in reproductive-aged women. However, endometriosis is more frequently encountered in women with chronic pelvic pain and…
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Endometriosis-associated pain control by contraceptive implant or intrauterine system
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The most common symptoms are dysmenorrhea, dyspareunia, and chronic pelvic pain, all of which affect the quality of women’s lives. Several studies investigating the…
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Pelvic pain, congenital genital tract anomalies and endometriosis
By Hale Goksever Celik
Any failure during development and differentiation of female genital tract results in congenital tract anomalies. The origin of the hymen is the union of the caudal portion of the paramesonephric ducts and the urogenital sinus. It functions as a mechanical…
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What clinicians know about adenomyosis? Any association with severe endometriosis?
By Selma Oransay
Dior et al. from the Royal Women's Hospital in Parkville, Australia, designed a prospective study to assess the association between severity of endometriosis and sonographic evidence of adenomyosis (SEOA) in their recently published article appearing in The Journal of Minimally…
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Endometriosis: A review on anatomic principles and the management
By Irem Onur
In the study of Alimi et al. which has been published in the journal Cureus, various aspects of endometriosis such as the pathophysiology, the anatomy, the pain mechanism, the perineural spread theory, clinical manifestations, diagnosis, and imaging, infertility, unusual cases,…
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The pain and its severity in deeply infiltrating endometriosis patients
By Selma Oransay
Liang et al. from the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Sun Yat-sen University, China, recently published an interesting paper in the Journal of Pain Research, a prospective study to reveal the relationship between neurogenesis and other potential…
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The diagnosis and management of endometriosis in Korea
By Selma Oransay
The Korean Society of Endometriosis has scrutinized the present published literature of endometriosis in the domestic and international platform to provide new guidelines and the clinical management of the disease. The study was recently published in the journal "Obstetrics and Gynecology…
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Best endometriosis articles of the past year.
By Selma Oransay
Dr.Stowall, from the Department of Obstetrics and Gynecology of Methodist Hospital, Dallas, Texas, USA penned this letter and recently published it in the Journal of Obstetrics and Gynecology to show his remarks of importance on four best publications of the…
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By Deniz KocasEndometriosis, Pain and Quality of Life
By Deniz Kocas
Although studies show that pain in endometriosis is associated with decreased health-related quality of life (HRQoL), details as to which pain symptoms contribute to such a decline have not been explored. For the first time in this study, researchers from…
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Women recommended laparoscopy for chronic pelvic pain
By Irem Onur
Chronic pelvic pain is a diagnostic and therapeutic dilemma. It has many etiologies in many organ systems. Clinician and patient factors affect the management of chronic pelvic pain. Mirowska-Allen K.L. et al. have recently published an article titled, “The characteristics of…
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Impact of coping strategies on quality of life of adolescents and young women with endometriosis.
By Deniz Kocas
González-Echevarría et al. report in J Psychosom Obstet Gynaecol. that symptoms caused by endometriosis have been found to be associated with negative quality of life (QoL) in women with endometriosis and the type of coping strategies adopted by patients have been shown…
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Predictors of psychological distress
By Deniz Kocas
Studies have now established that endometriosis can negatively impact mental health and quality of life, however, some studies show that not all women with endometriosis are necessarily more distressed than healthy women. This suggests that individual differences may explain women’s’…
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Could Gabapentin Make my Pain Go Away?
By Özge Özkaya
Gabapentin could effectively reduce endometriosis-associated pain, according to a new study published in the Journal of Pain Research. The study that was conducted in mice and endometriotic tissues from patients suggests that certain proteins present on the surface of cells…
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By Yu YuExercise can improve pelvic pain and posture associated with endometriosis
By Yu Yu
Nearly half of women affected by endometriosis have mild to severe chronic pelvic pain (CPP). Clinically, postural changes are frequently seen in CPP sufferers. These postural changes can include uneven positions, shortenings, antalgic postures, and tensions. Moreover, endometriosis is also…
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By Kasthuri NairAdolescents with Endometriosis are More Susceptible to Migraines
By Kasthuri Nair
Miller et al. recently published an article titled “The prevalence of migraines in adolescents with endometriosis” in Fertility and Sterility. The main purpose of the study was to determine if adolescents with endometriosis experience more migraines than those without endometriosis.…
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Does Endometriosis Cause Infertility?
By Özge Özkaya
Infertility may be related to the localization of endometriosis involvement according to a study published in the Journal of Obstetrics and Gynaecology. This finding is in agreement with the results of previous studies and could help clinicians in their decision…
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Laparoscopic Bowel Resection Can Be Beneficial Rectosigmoid Endometriosis
By Kasthuri Nair
Riiskjær et al. recently published a paper titled “Pelvic Pain and Quality of Life Before and After Laparoscopic Bowel Resection for Rectosigmoid Endometriosis: A Prospective, Observational Study” in Diseases of the Colon & Rectum. This paper focuses on the effects…
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A Combination Treatment of Psychotherapy With Somatosensory Stimulation for Pain Reduction
By Kasthuri Nair
Women suffering from endometriosis often cite pelvic pain, anxiety, and depression as some of the worst core symptoms experienced due to the disease; however, emerging research has shown these signs, specifically pelvic pain, may be influenced by psychological trauma. In…
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A New Treatment Time-Table for Controlling Endometriosis-Associated Pelvic Pain
By Kasthuri Nair
It is no secret that Endometriosis is an extremely painful disease. Unfortunately, science has yet to determine a treatment that can effectively treat the disease or the associated pain. In their paper titled “Ethinylestradiol 20 mg/drospirenone 3 mg in a…
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Reduced vascularization in ovarian endometriomas associated with less pain
By Yu Yu
Angiogenesis, i.e., the development of new blood vessels is believed to play an important role in endometriosis pathogenesis and symptoms. Endometriosis is associated and requires neovascularization to proliferate, invade surrounding normal structure in order to establish an endometriotic lesion. Ovarian…
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Combo Therapy of Micronized palmitoylethanolamide/trans-polydatin for Endometriosis Pain
By Kasthuri Nair
Endometriosis is a painful illness and many researchers in the field work to offer women with the disease some form of respite from the suffering. Indraccolo, Indraccolo, and Mignini are three such researchers and they recently published a paper titled…
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Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist.
By Yu Yu
Taylor et al. presented an exciting recent study in The New England Journal of Medicine. This article reported the results from a multicentre, double-blind, randomized, placebo-controlled phase 3 trials of elagolix for the treatment of endometriosis-associated pain. As women with…
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By Demet Candaş GreenWomen with endometriosis suffer from anxiety and depression
By Demet Candaş Green
Endometriosis is considered a disabling condition that may significantly affect social relationships, sexuality and mental health of patients. Women who suffer from endometriosis report high levels of anxiety and depression and other psychological disorders. In this review article, the authors…
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By Karime Kalil MachadoPatient-completed or symptom-based screening tools for endometriosis: a scoping review.
By Karime Kalil Machado
Endometriosis affects approximately 10% of women in reproductive age. Its clinical presentation is variable, and symptoms, such as chronic pelvic pain, may overlap with those of other benign conditions, making differential diagnosis challenging. Therefore, a patient-completed screening questionnaire could potentially…
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Does laparoscopic excision or laparoscopic ablation offer the best long-term pain relief from endometriosis?
By Murat Osman
This systematic and meta-analysis of several studies aimed to compile data regarding the reduction of dysmenorrhea (menstrual pain), dyschezia (difficult defecation), dyspareunia (painful sexual intercourse), chronic pelvic pain and Endometriosis Health Profile (EHP-30) score 2-12 months after treatment. Visual analog scale (VAS)…
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By Ezio RosatoNew Molecular Targets for the Treatment of Endometriosis-Associated Pain
By Ezio Rosato
The study identifies potential new targets for alleviating chronic pelvic pain that afflicts many women with endometriosis. A new study published in the scientific journal Redox Biology shows that molecules called microRNAs could be a potential new target to combat…
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