Postmenopausal endometriosis: Is it a rare phenomenon?

Postmenopausal endometriosis: Is it a rare phenomenon? By Hale Goksever Celik

Endometriosis, the estrogen-dependent disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity, is generally diagnosed in the reproductive-aged women. However, recent literature proved that this disease can also be observed in the premenopausal and…

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A Routine Pelvic Ultrasound Examination Should Include an Evaluation for Endometriosis

A Routine Pelvic Ultrasound Examination Should Include an Evaluation for Endometriosis By Özge Özkaya

Routine pelvic ultrasound examination should be extended beyond the uterus and ovaries into the posterior and anterior pelvic compartments, according to Australian doctors.  With such examinations, deep infiltrating endometriosis nodules can be searched, say the authors, allowing women to be…

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All aspects of endometriosis reviewed with focus on modern management

All aspects of endometriosis reviewed with focus on modern management By Engin Aydin

Dr. Chapron and associates from academic centers in France published in Nature Review Endocrinology, a comprehensive review on endometriosis. The article is inclusive of all aspects of endometriosis but especially focuses on the management of the disease with its contemporary status.  Having a…

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Clinical Evaluation of Endometriosis-Associated Pain

Clinical Evaluation of Endometriosis-Associated Pain By Nadire Duru

Endometriosis has a noteworthy impact on the quality of life of the patients diagnosed with it since it is associated with unpleasant conditions such as endometriosis-associated pain. The diagnosis of endometriosis is not always straightforward because of the varying symptoms…

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Primary care physicians have a crucial role in the early diagnosis of endometriosis

Primary care physicians have a crucial role in the early diagnosis of endometriosis By Engin Aydin

Dr. Verket and associates from the University of Oslo, Norway, published their cross-sectional anonymous postal questionnaire study in "BMJ open". Diagnosing endometriosis is difficult because dysmenorrhea, dyspareunia, and infertility are also common among other diseases. The most accurate and reliable diagnosis…

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Integrated bioinformatic analysis for endometriosis diagnosis

Integrated bioinformatic analysis for endometriosis diagnosis By Nadire Duru

Endometriosis is considered as a non-malignant disease, but it is associated with several unfavorable conditions including non‑menstrual pelvic pain and infertility. Surgical resection and hormone suppression are common means of treatments; however, several side-effects and the recurrence are not preventable.…

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Endometriosis and Women’s Tendency Towards Blood Clotting

Endometriosis and Women’s Tendency Towards Blood Clotting By Özge Özkaya

Women with ovarian endometriomas have an abnormally increased tendency toward blood clotting, study shows. Researchers think that this is due to the inflammatory nature of endometriosis. So abnormal coagulation parameters could be used to diagnose endometriosis, however, more detailed studies…

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A review of endometriosis in adolescent girls and young women

A review of endometriosis in adolescent girls and young women By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease which is commonly diagnosed in reproductive-aged women. On the other hand, this disease can develop earlier in life due to different etiopathogenetic mechanisms. Especially adolescents who experienced neonatal uterine bleeding are under the risk for…

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Circulating Endometrial Cells

Circulating Endometrial Cells By Yu Yu

Endometriosis is difficult to diagnose because of non-specific symptoms. Currently, there is no biomarker that allows for non-invasive diagnosis of the condition.  Surgical laparoscopy remains the standard for diagnosis. Circulating endometrial cells (CECs) is the lymphovascular spread of endometrial cells.…

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New Protein for Endometriosis Diagnosis

New Protein for Endometriosis Diagnosis By Özge Özkaya

A protein called TIMP3 (tissue inhibitor of metalloproteinase-3) could be used for the diagnosis and prognosis (likely course) of endometriosis.  The early diagnosis of endometriosis is of paramount importance because it can help to diagnosis and thus initiate the right…

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Endometriosis and the quality of life

Endometriosis and the quality of life By Selma Oransay

Recent developments of technics and improvement of skill in the laparoscopic field increased the courage of clinicians to attempt early and multiple diagnostic operations on endometriotic patients. Vanuccini et al. from NEUROFARBA, University of Florence, Florence, Italy recently published their…

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How Long Does it Take to Be Diagnosed with Endometriosis?

How Long Does it Take to Be Diagnosed with Endometriosis? By Özge Özkaya

It takes a median of eight years to reach a diagnosis of endometriosis from when the symptoms of the condition first appear confirmed a new British study. Interestingly, it seems that the earlier the symptoms appear, the later the disease…

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Adolescent dysmenorrhea and future endometriosis

Adolescent dysmenorrhea and future endometriosis By Selma Oransay

Dysmenorrhoea is typically classified as primary, or secondary due to underlying pathologies like fibroids, endometriosis, adenomyosis or uterine anomalies. Generally, long-term dysmenorrhea is present in endometriotic patient's anamnesis, but until recently, the research to clarify this connection remained retrospective. Knox et…

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Which Diagnosis Technique is Better?

Which Diagnosis Technique is Better? By Özge Özkaya

Transvaginal ultrasound provides a more accurate localization of vaginal and recto-vaginal endometriosis compared to magnetic resonance imaging (MRI) according to a study published in the International Journal of Gynecology & Obstetrics. However, MRI has better accuracy in detecting bladder endometriosis…

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MRI or TVS for accurate diagnosis of rectosigmoid endometriosis?

MRI or TVS for accurate diagnosis of rectosigmoid endometriosis? By Demet Candaş Green

Rectosigmoid endometriosis (RE) is seen in about 90% of patients with bowel endometriosis. Rectosigmoid is the region between the rectum and the sigmoid colon, which is a region easily accessed and assessed by two most common noninvasive imaging modalities –…

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Adenomyosis (endometriosis interna): an enigmatic disease that has to be discovered yet

Adenomyosis (endometriosis interna): an enigmatic disease that has to be discovered yet By Engin Aydin

Scientists, Drs. Vannuccini and Petraglia from Italy have published an open access comprehensive review of Adenomyosis in "F1000Research" in March 2019 issue. Adenomyosis is a uterine disorder in which endometrial glands and stroma are pathologically demonstrated within the myometrium, i.e.…

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PAX8 immunohistochemistry in the diagnosis of Extragenital Endometriosis

PAX8 immunohistochemistry in the diagnosis of Extragenital Endometriosis By Serdar Balci

This study is performed by Arakawa T et al., from the University of Tokyo, Tokyo, Japan, and the results are published in Reproductive Sciences. Endometriosis is seen in many organs including peritoneum, ovaries, bowel, bladder, and even lung. Histopathologic diagnosis may…

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Bowel endometriosis: What you need to know

Bowel endometriosis: What you need to know By Demet Candaş Green

When the endometrial tissue infiltrates the intestinal walls and reaches inside the intestines, this condition is called "bowel endometriosis". It is estimated that between 3.8% and 37% of women with endometriosis are affected by bowel endometriosis. The endometriosis lesions infiltrating…

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Development of Less Invasive Diagnostic Tests for Endometriosis Through Proteomics

Development of Less Invasive Diagnostic Tests for Endometriosis Through Proteomics By Murat Osman

Proteomics is a field which utilizes various methods to carry out large-scale studies of proteins. Due to the inherent nature of the field, proteomics focuses on the identification, localization, and functional analysis of the protein make-up of a given type…

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A Brief Review of Endometriosis

A Brief Review of Endometriosis By Timur Seckin

Endometriosis is a common disease among women of reproductive age. It is more frequently seen among women without prior pregnancies, women with a family history of endometriosis, and women with abnormal menstrual periods. Peiris et al., researchers from the United…

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Endometriosis: A review on anatomic principles and the management

Endometriosis: A review on anatomic principles and the management By Irem Onur

In the study of Alimi et al. which has been published in the journal Cureus, various aspects of endometriosis such as the pathophysiology, the anatomy, the pain mechanism, the perineural spread theory, clinical manifestations, diagnosis, and imaging, infertility, unusual cases,…

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Preoperative Staging of Endometriosis: The Value of MRI After Dynamic Transvaginal Ultrasound

Preoperative Staging of Endometriosis: The Value of MRI After Dynamic Transvaginal Ultrasound By Irem Onur

Since endometriosis is a chronic and progressive disease, early diagnosis and proper staging are important for the patient and for the clinician to discuss and plan the required surgical procedures for treatment. Common diagnostic tools for pre-operative staging of deep…

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How to evaluate ureteral endometriosis : A review of the literature

How to evaluate ureteral endometriosis :  A review of the  literature By Selma Oransay

In this recently published review of the literature, Barra et al. from Genova, Italy intend to provide a useful tool to guide physicians in the management of deep infiltrating endometriosis. Authors elected 67 abstracts from Pubmed and Medline in accordance with PRISMA…

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A Better Way to Diagnose Endometriosis?

A Better Way to Diagnose Endometriosis? By Özge Özkaya

Three proteins found in the blood and endometrial tissues could be used to determine the stage of endometriosis and the severity of painful periods according to a study published in the journal Current Medical Science. Evaluating the levels of these…

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How are endometriosis patients managed clinically?

How are endometriosis patients managed clinically? By Irem Onur

This review paper by Falcone and Flyckt, entitled “Clinical Management of Endometriosis” published in the journal Obstetrics & Gynecology aims to summarize the current strategies for treating endometriosis patients with pain, pelvic dysfunction, and subfertility related to their disease. There are many…

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Detecting endometriosis using peripheral blood

Detecting endometriosis using peripheral blood By Yu Yu

Laparoscopic visualization of endometriotic lesions with histological confirmation is the gold standard for the diagnosis of endometriosis. However, this diagnostic procedure, due to the need for laparoscopy and variability of disease/symptoms, can have a major delay up to 8-10 years…

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Catching Endometriosis Early

Catching Endometriosis Early By Kasthuri Nair

Li et al., a group primarily from Sun Yat-sen University in the People’s Republic of China, recently published an article titled “Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages” in Reproductive Biology and Endocrinology. The…

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A Way to Better Diagnose Colorectal Endometriosis

A Way to Better Diagnose Colorectal Endometriosis By Özge Özkaya

Combining magnetic resonance imaging (MRI) with computed tomography-based virtual colonoscopy (CTC) can make the assessment of colorectal endometriosis more accurate. This is important because it can help doctors plan the surgery better and inform their patients. In order to evaluate…

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An Unusual Case "Free Floating Omental Endometrioma"

An Unusual Case By Kasthuri Nair

Capaccione et al. published an article in Radiology Case Reports titled “Massive endometrioma presenting with dyspnea and abdominal symptoms.” This publication is centered around a particularly unique case report of a woman who was ultimately diagnosed with endometriosis. The patient…

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The Past, Present, and Future of Diagnosing Endometriosis

The Past, Present, and Future of Diagnosing Endometriosis By Kasthuri Nair

This review titled “Endometriosis: Epidemiology, Diagnosis and Clinical Management” published in Current Obstetrics and Gynecology Reports examines the distribution and factors associated with endometriosis. The analysis by Parasar, Ozcan, and Terry also delineates potential biomarkers and risk factors that could…

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The Challenging Path to Diagnosis

The Challenging Path to Diagnosis By Kasthuri Nair

Kallia O. Wright, a professor at Illinois College, recently published her essay titled “You have Endometriosis”: Making Menstruation Related Pain Legitimate in a Biomedical World” in Health Communication. This essay delineates the author’s experience with endometriosis. The author started experiencing…

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Skin Endo Diagnosis

Skin Endo Diagnosis By Özge Özkaya

High-frequency ultrasound can be very useful for the early diagnosis of cutaneous endometriosis according to a study published in the journal Skin Research and Technology. The diagnostic tool could be used in patients who have unusual cyclical pain even before…

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Diagnostic and treatment guidelines for gastrointestinal and genitourinary endometriosis.

Diagnostic and treatment guidelines for gastrointestinal and genitourinary endometriosis. By Murat Osman

Endometriosis may affect the pelvic reproductive system, but it can also be found in non-reproductive organs such as the gastrointestinal and urinary tract. The article outlined below discusses the diagnosis and management of genitourinary and gastrointestinal endometriosis. Gastrointestinal endometriosis: The…

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MRI Best at Detecting Intestinal Deep Infiltrating Endometriosis

MRI Best at Detecting Intestinal Deep Infiltrating Endometriosis By Özge Özkaya

Magnetic resonance imaging (MRI) seems to be a better method in identifying deep infiltrating endometriosis in the intestine compared to two-dimensional ultrasonography (2DUS), found a study by researchers in Italy and Spain. However, this does not seem to be the…

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How good are the current guidelines on endometriosis? 

How good are the current guidelines on endometriosis?  By Dr. Youngran Park

The endometriosis was first described in 1860, yet the etiology and pathogenesis remain poorly understood. Treatment strategies vary significantly between disease severity and the symptoms of pain and/or subfertility. These challenges have resulted in multidirectional research, and the comparability of…

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Do Adolescents and Adults Experience Endometriosis Differently?

Do Adolescents and Adults Experience Endometriosis Differently? By Özge Özkaya

Symptoms of endometriosis seem to be the same between women surgically diagnosed during adolescence and those diagnosed as adults, according to a study published in the American Journal of Obstetrics and Gynecology. For both age groups, pelvic pain was severe,…

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Ectoenzymes as endometriosis biomarkers

Ectoenzymes as endometriosis biomarkers By Yu Yu

The diagnosis of endometriosis is often delayed by 7 to 11 years because of the lack of a non-invasive diagnostic test. The ovarian endometriomas occur in about 17%-44% of women with endometriosis and cysts which contain endometrial tissue and fluid…

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Endometriosis early pointers

Endometriosis early pointers By Yu Yu

Endometriosis can take a long time to diagnose, thus associated with prolonged symptoms of pain, subfertility and patient frustration/demoralization. It can be difficult to diagnose clinically because the symptoms are common and non-specific so that GP can misconceive them as…

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Endometriosis Should be Diagnosed Timely and Properly

Endometriosis Should be Diagnosed Timely and Properly By Kasthuri Nair

The pain of endometriosis is often worsened by delayed diagnosis. The National Institute for Health Care and Excellence (NICE) recently published guidelines for the quick and accurate diagnosis of endometriosis. Jacqui Wise discusses these recommendations and their implications in her…

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Overview of NICE Endometriosis Guidelines

Overview of NICE Endometriosis Guidelines By Kasthuri Nair

In this article titled “Diagnosis and management of endometriosis: summary of NICE guidance,” Kuznetsov et al. talk through the recent endometriosis guidelines set forth by The National Institute for Health Care and Excellence (NICE). The BMJ publication hopes to elucidate…

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Endometriosis and Psychological Health: Butterflies from Deep Wounds

Endometriosis and Psychological Health: Butterflies from Deep Wounds By Kasthuri Nair

Endometriosis is a grueling disease in every sense of the word; however, most of the discussions center on the physical manifestations of the disease. Facchin et al. veer from the beaten path and examine the impact endometriosis have on a…

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Glycodelin and altered endometrial function in endometriosis

Glycodelin and altered endometrial function in endometriosis By Yu Yu

A laparoscopic examination is the only diagnostic tool for endometriosis to date. Since the procedure is invasive, there has been much effort by researchers to develop a biomarker for non-invasive diagnosis of endometriosis. To this end, there has been growing…

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"Kissing Round Ligaments" May Be a Sign of Bladder Endometriosis

By Özge Özkaya

Specific laparoscopic findings may help surgeons diagnose bladder endometriosis, a rare and often undiagnosed condition.  Bladder endometriosis is thought to affect only around one percent of patients with endometriosis. However, this could be an underestimation and many cases may go…

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More than Four Years Pass Before Endometriosis is Diagnosed After Symptoms First Appear

More than Four Years Pass Before Endometriosis is Diagnosed After Symptoms First Appear By Özge Özkaya

The average time that passes between the onset of symptoms such as pelvic pain and the diagnosis of endometriosis is 4.4 years on average, according to a study conducted by researchers at the pharmaceutical company Abbvie and published in the…

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