Myeloid-Derived Suppressor Cells are gaining importance in endometriosis

Myeloid-Derived Suppressor Cells are gaining importance in endometriosis By Nasuhi Engin Aydin

Dr. Wertel and associates from Polish academic centers published their sentimental review paper on the role of "Myeloid-Derived Suppressor Cells" in human diseases, in a recent issue of  Cells. Endometriosis, the most common gynecological disease affecting about 10% of women globally,…

Key Points Lay Summary

Which is the best for ovarian reserve preservation? Hemostatic agent or coagulation?

Which is the best for ovarian reserve preservation? Hemostatic agent or coagulation? By Bahar Yuksel

The way of ovarian parenchymal bed hemostasis following ovarian cystectomy is crucial for ovarian reserve protection, and discussions about different techniques on this issue are ongoing. Multiport laparoscopic surgery is the standard method for ovarian surgeries, but laparoendoscopic single-site cystectomy became…

Key Points Lay Summary

What Happens to Endometriosis Patients After Endometriosis Surgery?

What Happens to Endometriosis Patients After Endometriosis Surgery? By Özge Özkaya

Although few patients with endometriosis who undergo a hysterectomy need repeat surgery, up to 25% of them need minor surgery. Around 20% of patients who undergo conservative surgery with ovarian preservation require additional endometriosis surgery. Up to one in three…

Key Points Lay Summary

Optimal management of infertility in endometriosis patients

Optimal management of infertility in endometriosis patients By Hale Goksever Celik

Pelvic pain and infertility are the main symptoms of endometriosis patients. Although the pathophysiological mechanism for infertility is not clearly understood, there are several theories explaining decreased fertility potential in women with endometriosis. Ata and Telek, from Koc and Istanbul Universities…

Key Points Lay Summary

Endometriosis, ART, fertility preservation

Endometriosis, ART, fertility preservation By Selma Oransay

This review entitled "The impact of endometriosis on the outcome of assisted reproductive techniques: role of fertility preservation" was written by Necula et al. from Gynecology and Obstetrics Unit, Biel, Switzerland, and recently published in the journal "Hormone, Molecular Biology and Clinical…

Key Points Lay Summary

Tubo-ovarian abscess and endometriosis

Tubo-ovarian abscess and endometriosis By Bahar Yuksel

A tubo-ovarian abscess is the result of pelvic inflammatory disease in women and the previous reports demonstrated that almost one of the third women with a pelvic inflammatory disease had a tubo-ovarian abscess. The main treatment modalities for tubo-ovarian abscess…

Key Points Lay Summary

Cancer, is that a real risk?

Cancer, is that a real risk? By Yu Yu

Endometriosis is non-malignant but shares some similar features with cancer, such as the occurrence of local and distant foci, the ability to resist cell death, and the ability to invade other tissues, causing damage to the organs. Endometriosis also generates…

Key Points Lay Summary

Controlled use of bipolar cauterization as an alternative to endometrioma cystectomy

Controlled use of bipolar cauterization as an alternative to endometrioma cystectomy By Hale Goksever Celik

The main symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Ablation or coagulation of the cyst wall following laparoscopic drainage of endometrioma may be an alternative treatment for patients with pregnancy intention. Carbon dioxide, laser, and plasma energy…

Key Points Lay Summary

The influence of endometrioma and surgery on ovarian reserve

The influence of endometrioma and surgery on ovarian reserve By Dr. Youngran Park

Women with endometriosis and endometrioma, often have subfertility. These patients present considerable problems for the evaluation of ovarian reserve. One of the well-known ovarian reserve biomarkers is anti-Müllerian hormone (AMH) levels. So far, it was known that the reduction of…

Key Points Lay Summary

Impaired fertility potential in endometriosis patients

Impaired fertility potential in endometriosis patients By Hale Goksever Celik

Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis and sperm movements. Garcia-Fernandez and García-Velasco, from Edinburgh, UK and Madrid, Spain, published a mini-review titled “Endometriosis and Reproduction: What We Have…

Key Points Lay Summary

Ovarian, breast and endometrial cancer coexisting with endometriosis.

Ovarian, breast and endometrial cancer coexisting with endometriosis. By Selma Oransay

The invasive nature of endometriosis results in calling the disease " benign cancer". The transformation of endometriosis to malignancy is rare, but when compared to the general population, the relative risk of developing ovarian cancer is 4.2 times greater especially…

Key Points Lay Summary

KEYNOTE: Excision Without Mutilation: It’s Possible! -  Arnaud Wattiez, MD

KEYNOTE: Excision Without Mutilation: It’s Possible! -  Arnaud Wattiez, MD By Özge Özkaya

In his keynote lecture, Dr. Wattiez talks about the pros and cons of endometriosis surgery and the importance of tailoring endometriosis surgery to individual patients.  “Endometriosis is a disease that degrades patient’s wellbeing," Dr. Wattiez says and gives some examples…

Key Points Lay Summary

Operative techniques for Deep Endometriosis Surgery - Shaheen Khazali, MD

Operative techniques for Deep Endometriosis Surgery - Shaheen Khazali, MD By Özge Özkaya

In this presentation, Dr. Shaheen Khazali, an endometriosis surgeon specialized in gastrointestinal and urinary tract endometriosis excision and in neuropelveology, talks about the general principles and some techniques for endometriosis surgery focusing on rectovaginal endometriosis. He also describes the "ten…

Key Points Lay Summary

Role of Prophylactic Oophorectomy in Endometriosis Patients with Ovarian Cancer History in the family - Farr Nezhat, MD

Role of Prophylactic Oophorectomy in Endometriosis Patients with Ovarian Cancer History in the family - Farr Nezhat, MD By Özge Özkaya

Dr. Nezhat starts his presentation by outlining his objectives, which are to review the basics of cancer genetics, give an overview about endometriosis and ovarian cancer, discuss the pathogenesis of malignant transformation of endometriosis, and talk about the clinical implications…

Key Points Lay Summary

Further Evidence that endometriosis is related to tubal or ovarian cancer - Togas Tulandi, MD

Further Evidence that endometriosis is related to tubal or ovarian cancer - Togas Tulandi, MD By Selma Oransay

Most authors suggest an association of endometriosis mainly with clear cell, low-grade serous, and endometrioid ovarian cancer.  But in two large cohort studies, no correlation between them is reported (Olson et al. 2002 and Tseng et al. 2019) Dr. Tulandi…

Key Points Lay Summary

Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD

Limits of endometrioma surgery in infertility patients - Liselotte Mettler, MD, PhD By Selma Oransay

The removal of endometrioma may affect ovarian reserve because healthy follicles near endometrioma could also be excised during this procedure. Another concern about the ovarian reserve is that it may be already low before the surgery. Anti Mullerian Hormone (AMH)…

Key Points Lay Summary

In vitro fertilization protocols in endometriosis patients - Pinar Kodaman, MD., PhD.

In vitro fertilization protocols in endometriosis patients - Pinar Kodaman, MD., PhD. By Hale Goksever Celik

Infertility is frequently encountered in endometriosis patients because of anatomic distortion, alterations in endometrial receptivity, diminished tubal peristalsis, and sperm movements. Even though the disease stage and presence of endometrioma is negatively correlated with infertility, it is unpredictable which women…

Key Points Lay Summary

Endometrioma size and anti-Müllerian hormone levels

Endometrioma size and anti-Müllerian hormone levels By Hale Goksever Celik

Endometriotic lesions are encountered in different locations in the pelvic cavity, including but not limited to the ovaries, the pouch of Douglas, the ureters, the bladder, and the bowel. Cystic endometriosis lesions located in the ovary are called "endometrioma". Endometriomas have…

Key Points Lay Summary

Fallopian tube endometriosis

Fallopian tube endometriosis By Bahar Yuksel

Endometriosis affects various tissues including pelvic and extra-pelvic organs. Fallopian tube endometriosis is not a widely studied topic in endometriosis, hence the real incidence is unknown as not all studies evaluate microscopically diagnosed Fallopian tube endometriosis. In the retrospective database…

Key Points Lay Summary

Fallopian tubes and endometriosis

Fallopian tubes and endometriosis By Selma Oransay

There are multiple theories to explain the pathogenesis of endometriosis, among which the most popular one is Sampson's retrograde menstruation theory. The role of endometrial stem cells/progenitors are widely studied to support the origin of ectopic lesions in recent decades.…

Key Points Lay Summary

Clinical characteristics linked to recurrence of ovarian endometrioma

Clinical characteristics linked to recurrence of ovarian endometrioma By Nadire Duru

Endometriosis affects 10-15% of women. Three types of endometriosis are peritoneal, ovarian, and deep infiltrating endometriosis. Ovarian endometriosis is the most common type of endometriosis with a high rate of recurrence. Laparoscopy is the gold standard treatment for endometriosis and…

Key Points Lay Summary

Is oocyte cryopreservation useful for fertility preservation in ovarian endometriosis?

Is oocyte cryopreservation useful for fertility preservation in ovarian endometriosis? By Irem Onur

Women with endometriosis tend to have lower fecundity compared to normal couples. Furthermore,  endometrioma itself may reduce the ovarian reserve by altering ovarian physiology in the surrounding healthy ovarian tissue. The treatment for endometrioma is surgical removal in most cases, however,…

Key Points Lay Summary

Immune System, Cytokines and Endometriosis

Immune System, Cytokines and Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent chronic disease. Diagnosing endometriosis is difficult because the signs and symptoms vary considerably. Therefore, the discovery of a reliable non-invasive diagnostic biomarker would represent a major advance for the clinical diagnosis of endometriosis.  It has been…

Key Points Lay Summary

The link between ovarian cancer and endosalpingiosis

The link between ovarian cancer and endosalpingiosis By Timur Seckin

The presence of benign glands lined by tubal-type epithelium in the peritoneum and subperitoneal tissues is called "endosalpingiosis". A recent study that investigates the possible association between endosalpingiosis and ovarian cancer was conducted by Hermens et al., from the Netherlands, and has…

Key Points Lay Summary

Fertility conservation in women with endometriosis

Fertility conservation in women with endometriosis By Selma Oransay

Endometriosis affects 10-15% of women in their reproductive period and almost half of them may need Assisted Reproductive techniques to conceive. Moreover, increased malignancy risk is threatening the women with severe endometriosis in addition to their decreased ovarian reserve. Due…

Key Points Lay Summary

Long-term Pregnancy Results after Surgical Removal of Endometrioma

Long-term Pregnancy Results after Surgical Removal of Endometrioma By Irem Onur

Sun et al., from China, investigated the pregnancy outcomes and the related factors in patients with endometrioma and stage III-IV endometriosis along with a long-term follow-up postoperatively. Their study has recently been published in the journal named "Advances in Therapy".…

Key Points Lay Summary

Adiposity, endometriosis type and severity

Adiposity, endometriosis type and severity By Selma Oransay

Dr. Jiyoung from the division of Public Health, Department of Family and Preventive Medicine of the University of Utah, planned a prospective cross-sectional study to assess whether there is an inverse relationship between the adiposity and endometriosis. The results of…

Key Points Lay Summary

Endometriosis and Women’s Tendency Towards Blood Clotting

Endometriosis and Women’s Tendency Towards Blood Clotting By Özge Özkaya

Women with ovarian endometriomas have an abnormally increased tendency toward blood clotting, study shows. Researchers think that this is due to the inflammatory nature of endometriosis. So abnormal coagulation parameters could be used to diagnose endometriosis, however, more detailed studies…

Key Points Lay Summary

Rare lesions in the pathologic examinations of endometriosis.

Rare lesions in the pathologic examinations of endometriosis. By Selma Oransay

Dr. Glenn McCluggage from the Department of Pathology, Belfast Health, and Social Care Trust, penned a review about selected uncommon variants of endometriosis or benign alterations that may cause difficulties of pathologic diagnosis and provided all related histopathological illustrations in…

Key Points Lay Summary

A review of endometriosis in adolescent girls and young women

A review of endometriosis in adolescent girls and young women By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease which is commonly diagnosed in reproductive-aged women. On the other hand, this disease can develop earlier in life due to different etiopathogenetic mechanisms. Especially adolescents who experienced neonatal uterine bleeding are under the risk for…

Key Points Lay Summary

Endometriosis and ovarian reserve

Endometriosis and ovarian reserve By Hale Goksever Celik

Endometriosis is most frequently encountered in reproductive-aged women. Its prevalence is 10-15% in the general population of this age. However, endometriosis is diagnosed more frequently in infertile women with a prevalence of 25-40%. Although the exact mechanism explaining the association between…

Key Points Lay Summary

Factors affecting risk of ovarian endometriosis malignancy

Factors affecting risk of ovarian endometriosis malignancy By Özge Özkaya

Getting married when older, having had ovarian endometriosis for longer, giving birth in a shorter time, and other complications in the uterus that are benign may all increase the risk of ovarian endometriosis malignancy. This is according to a study…

Key Points Lay Summary

Serum anti-Müllerian hormone levels for predicting spontaneous pregnancy after endometriosis surgery

Serum anti-Müllerian hormone levels for predicting spontaneous pregnancy after endometriosis surgery By Hale Goksever Celik

Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Although there are several medical and surgical therapeutic options, the most effective treatment modality has not yet been elucidated.    The main…

Key Points Lay Summary

Endometriosis as an epigenetically regulated disease

Endometriosis as an epigenetically regulated disease By Dr. Youngran Park

Endometriosis is defined as the abnormal growth of endometrial tissue outside of the uterus. It affects about 10% of reproductive age women resulting in severe pain and infertility. Among various theories of endometriosis pathogenesis, not a single one has successfully…

Key Points Lay Summary

Consquences of endometriosis in menopausal period.

Consquences of endometriosis in menopausal period. By Selma Oransay

Marie-Scemama et al. from Foch Hospital, Suresnes, France, referred to endometriosis and menopause which is an actual cruising topic and recently published it in the journal named "Hormone Molecular Biology and Clinical Investigation". Endometriosis a well-known estrogen-dependent disease has three…

Key Points Lay Summary

A new technique for laparoscopic management of ovarian endometriosis.

 A new technique for laparoscopic management of ovarian endometriosis. By Selma Oransay

To cause a minimal hazardous effect on ovarian reserve during laparoscopic surgery of endometriomas is always a great concern for clinicians. Shaltout et al. from Cairo University, Egypt, examined the effect of "Surgicel" on preventing the recurrence of endometriomas and…

Key Points Lay Summary

Does ovarian endometriosis affect oocyte quality?

Does ovarian endometriosis affect oocyte quality? By Dr. Youngran Park

Endometriosis is a very common gynecological disorder affecting women in their reproductive years. It is reported that patients with endometriosis have reduced implantation and pregnancy rates compared to healthy women. According to the various previous studies, the quality of the…

Key Points Lay Summary

Impact of hemostatic techniques used in endometrioma surgery on ovarian function

Impact of hemostatic techniques used in endometrioma surgery on ovarian function By Demet Candaş Green

This publication reports on an ongoing clinical trial that aims to assess whether the hemostatic techniques (methods to stop bleeding) used in ovarian endometrioma surgery have damaging effects on ovarian function. The clinical trial stemmed from a multitude of inconclusive…

Key Points Lay Summary

Does Endometriosis Reduce Ovarian Reserve?

Does Endometriosis Reduce Ovarian Reserve? By Özge Özkaya

Markers of ovarian reserve are worse in infertile women with endometriosis compared to women who cannot conceive due to male factor infertility regardless of whether or not they have had ovarian surgery. This finding is important because it suggests that…

Key Points Lay Summary

A new trial to reduce the failure of IVF/ICS protocols in severe endometriosis

A new trial to reduce the failure of IVF/ICS protocols in severe endometriosis By Selma Oransay

Kong et al., from the first affiliated hospital of Zhengzhou University, China, recently published this single-blinded, a multicentered and randomized controlled study in the Journal of Reproductive Health, with the aim to find a safer and more effective ovulation induction regimen for patients with…

Key Points Lay Summary

Epithelial Mutations in Endometriosis

Epithelial Mutations in Endometriosis By Dr. Youngran Park

A substantial body of epidemiologic evidence suggests a link between endometriosis and epithelial ovarian cancer, but a plausible underlying mechanism has remained elusive. Here, Dr. Bulun group from Northwestern University provide a focused review of the literature and discuss the…

Key Points Lay Summary

Antimullerian Hormone, endometrioma and ovarian reserve

Antimullerian Hormone, endometrioma and ovarian reserve By Selma Oransay

Younis et al. from Baruch-Padeh Medical Center, Poriya, Israel, designed a review study on ovarian reserve alterations before and after endometrioma surgery that recently documented in "Human Reproduction Update". The authors examined the electronic databases of articles published between January…

Key Points Lay Summary

Ovarian stimulation regimes: Concerns on progression or recurrence of endometriosis

 Ovarian stimulation regimes: Concerns on progression or recurrence of endometriosis By Selma Oransay

Somigliana et al., from the University of Milan, Italy, performed a literature review to predict the endometriosis-enhancing effect of ART regimes on infertile women and reported their results in Reproductive Biomedicine Online. Their points of interest were increasing dysmenorrhea, dyspareunia, non-menstrual pain and…

Key Points Lay Summary

Estrogen Receptor Signaling and Endometriosis-Associated Ovarian Cancer

Estrogen Receptor Signaling and Endometriosis-Associated Ovarian Cancer By Selma Oransay

Andersen et al. published a prospective cohort study in the Journal of Hormones and Cancer to enlighten the estrogen signaling pathway during the transition from endometriosis to endometriosis-associated ovarian cancer. Given the shared pathway of endometriosis and ovarian cancer as…

Key Points Lay Summary

A link between endometrioid ovarian carcinoma and endometriosis.

A link between endometrioid ovarian carcinoma and endometriosis. By Selma Oransay

Ciavattini et al.from Polytechnic University Ancona, Italy create a pilot study which recently published in Oncology Letters to clarify the link between endometriosis and endometrioid ovarian cancer. The unfolded protein response (UPR) activity as a promoter of neoplastic progression of malignancies is…

Key Points Lay Summary

Which comes first in endometriosis management: In vitro fertilization or surgery?

Which comes first in endometriosis management: In vitro fertilization or surgery? By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence is found to be 7%–10%, but among infertile women, it increases up to 50%. Early diagnosis and personalized management are important to…

Key Points Lay Summary

Building an ultrasonographic database for superficial endometriosis.

Building an ultrasonographic database for superficial endometriosis. By Selma Oransay

Chowdary et al. from University of Auckland, Australia, recently published a retrospective, small group study in Australian New Zeland Journal of Obstetrics and Gynecology, to demonstrate ultrasonographic findings of mild endometriosis patients with pelvic pain are associated with their laparoscopic diagnosis.…

Key Points Lay Summary

The association between the development of endometriosis and dietary habits

The association between the development of endometriosis and dietary habits By Hale Goksever Celik

Endometriosis is a chronic disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence is found to be approximately 10% in the general population. Endometriosis is associated with infertility, pelvic pain, and increased…

Key Points Lay Summary

Clonal Proliferation and Cancer Associated Mutations in normal uterine endometrium and endometriosis

Clonal Proliferation and Cancer Associated Mutations in normal uterine endometrium and endometriosis By Serdar Balci

Suda et. al., from Niigata University, Japan, has published the article entitled "Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium" in Cell Reports. There are many theories for endometriosis development (retrograde menstruation, coelomic metaplasia, Müllerian remnants),…

Key Points Lay Summary

Does the presence of endometriosis increase the risk of gynecologic malignancies?

Does the presence of endometriosis increase the risk of gynecologic malignancies? By Serdar Balci

Endometriosis shares common risk factors with endometrial carcinoma and ovarian carcinomas such as obesity, type 2 diabetes, hyperestrogenism, and reproductive characteristics. Endometriosis is also known to be a risk factor for gynecologic malignant tumors. In this study, Li et.al. have…

Key Points Lay Summary

Further Results From the FEELING Study Published

Further Results From the FEELING Study Published By Özge Özkaya

Some women are more likely to develop deep infiltrating endometriosis according to the further analysis of the results of the FEELING study. These are women who: are married, are older,  have siblings,  have had a prior pregnancy,  or for whom…

Key Points Lay Summary

Targeted therapy biomarkers in endometriosis associated ovarian carcinomas

Targeted therapy biomarkers in endometriosis associated ovarian carcinomas By Serdar Balci

Endometriosis in ovaries is a known precursor of endometrioid and clear cell carcinomas. They may be resistant to classical therapies. Researchers search for alternative and targeted therapy options. This study, from the University of Campinas, Campinas, São Paulo, Brazil, will be…

Key Points Lay Summary

Does ovarian endometrioma damage the ovarian reserve?

Does ovarian endometrioma damage the ovarian reserve? By Dr. Youngran Park

Ovarian endometriomas are commonly present in 17% to 44% of women with endometriosis and are often associated with infertility and pelvic pain. There are several treatment options including surgical treatment. Cyst excision is associated with better results in terms of…

Key Points Lay Summary

How to preserve fertility in women with “ovarian endometriosis”?

How to preserve fertility in women with “ovarian endometriosis”? By Hale Goksever Celik

Although there are many treatment modalities in endometriosis, optimal treatment has not been developed yet. The aim of the treatment is to reduce pain, to preserve and improve fertility and to delay recurrence. Ovarian ischemic and perfusion damage during endometriosis…

Key Points Lay Summary

Polymorphism of IL12B May Help Solve Endometriosis

Polymorphism of IL12B May Help Solve Endometriosis By Kasthuri Nair

Zhao et al. recently published a paper titled “A functional promoter polymorphism in interleukin 12B gene is associated with an increased risk of ovarian endometriosis” in Gene. The research group from Hebei Medical University wanted to explore the potential roles…

Key Points Lay Summary

Epigenetic link between endometriosis and cancer

Epigenetic link between endometriosis and cancer By Nasuhi Engin Aydin

Although endometriosis is considered a benign condition the cellular, histologic, and molecular data strongly demonstrate that endometriosis has neoplastic characteristics. There is strong evidence that endometriosis shares striking features with malignancy like normal tissue dissemination, invasion, and organ damage, as well as new vessel formation (neoangiogenesis).  In…

Key Points Lay Summary

Key to Understanding Ovarian Endometriosis may lay in the Peptides

Key to Understanding Ovarian Endometriosis may lay in the Peptides By Kasthuri Nair

Xue et al. recently published a paper titled “Peptidomic Analysis of Endometrial Tissue from Patients with Ovarian Endometriosis” in Cellular Physiology and Biochemistry. The research group from various departments of Nanjing Medical University wished to better understand the pathogenesis of…

Key Points Lay Summary

Managing of endometriosis and associated ovarian cancer risk

Managing of endometriosis and associated ovarian cancer risk By Yu Yu

According to a number of studies, endometriosis is associated with moderate increase in ovarian cancer risk. This risk is elevated in subjects with a long-standing history of untreated ovarian endometriosis. Endometriosis is particularly associated with risk for certain histological subtypes…

Key Points Lay Summary

Extending the Female Fertility Clock

Extending the Female Fertility Clock By Kasthuri Nair

Varela, Sanchez-de-Puerta, and Garcia-Velasco are a group of scientists from various institutions in Spain and they recently published a review article titled “Fertility, IVF and reproductive genetics” in Current Opinion in Obstetrics and Gynecology. In this publication, the authors discussed…

Key Points Lay Summary

Increasing IVF Success Rates

Increasing IVF Success Rates  By Özge Özkaya

DuoStim or double ovarian stimulation is the most promising approach to increase the number of eggs collected to be used in IVF, according to a review article published in the journal Current Opinion in Obstetrics and Gynecology.  Pain and infertility…

Key Points Lay Summary

HOXA10: A Culprit in Endometriosis Disease Progression

HOXA10: A Culprit in Endometriosis Disease Progression By Kasthuri Nair

Zheng et al., a group of authors from the Aerospace Center Hospital in Bejing and from the First Affiliated Hospital of Wenzhou Medical University in Wenzhou, recently published a paper in Reproductive Sciences entitled “Decreased Expression of HOXA10 May Activate the…

Key Points Lay Summary

Stem cell therapy for the premature ovarian failure 

Stem cell therapy for the premature ovarian failure  By Dr. Youngran Park

Premature ovarian failure (POF) is one of the common disorders found in women. The cause of POF is not fully known, but various factors have been suggested. In genetically, X and autosomes chromosome abnormalities could result in some POF. The…

Key Points Lay Summary

No Link Found Between Vitamin D and Endometriosis

No Link Found Between Vitamin D and Endometriosis By Kasthuri Nair

Buggio et al., a group of scientists from the Ospedale Maggiore Policlinico, Universita` degli Studi in Milan, recently published a paper in the Reproductive Sciences titled “25-Hydroxyvitamin D Serum Levels and Endometriosis: Results of a Case-Control Study.” The publication sought…

Key Points Lay Summary

Does Endometriosis Cause Infertility?

Does Endometriosis Cause Infertility? By Özge Özkaya

Infertility may be related to the localization of endometriosis involvement according to a study published in the Journal of Obstetrics and Gynaecology. This finding is in agreement with the results of previous studies and could help clinicians in their decision…

Key Points Lay Summary

Benign Gynecological Tumors in Women with Endometriosis

Benign Gynecological Tumors in Women with Endometriosis By Kasthuri Nair

Matalliotaki et al. recently published a paper titled “Coexistence of benign gynecological tumors with endometriosis in a group of 1,000 women” in Oncology Letters. The study had two main objectives. The first goal was to understand the link between endometriosis…

Key Points Lay Summary

Long-term Use of Dienogest can Prevent Recurrence of Endometriomas

Long-term Use of Dienogest can Prevent Recurrence of Endometriomas By Kasthuri Nair

Chandra et al. recently published a paper titled “Clinical experience of the long-term use of dienogest after surgery for ovarian endometriomas” in Obstetrics and Gynecology Science. The publication explored the benefits and repercussions associated with long-term use of dienogest, a…

Key Points Lay Summary

Are there any risk factor associated with the progression of endometriosis to ovarian cancer?

Are there any risk factor associated with the progression of endometriosis to ovarian cancer? By Murat Osman

Endometriosis is a disease whereby endometrial glands proliferate outside of the endometrial lining. Apart from causing significant morbidity, It has been found that endometriosis is associated with an increased risk of progression to endometroid and clear cell ovarian cancer. However,…

Key Points Lay Summary

Is the presence of endometriosis associated with a survival benefit in pure ovarian clear cell carcinoma?

Is the presence of endometriosis associated with a survival benefit in pure ovarian clear cell carcinoma? By Dr. Youngran Park

Ovarian clear cell carcinoma (OCCC) has been known to be associated with endometriosis for a long time. However, the impact of the presence of endometriosis around the tumor on the prognoses of women with OCCC is still controversial. To shed…

Key Points Lay Summary

When Endometriosis Becomes Malignant

When Endometriosis Becomes Malignant By Kasthuri Nair

Anglesio and Yong recently wrote a review titled “Endometriosis-associated Ovarian Cancers” that was published in Clinical Obstetrics and Gynecology. This review explored the relationship between endometriosis and ovarian cancers. It is important to note that this review is a compilation of…

Key Points Lay Summary

Women with Endometriosis Should Not Worry About Ovarian Cancer

Women with Endometriosis Should Not Worry About Ovarian Cancer By Kasthuri Nair

Kvaskoff, Horne and Missmer recently published an article in The Lancet titled “Informing women with endometriosis about ovarian cancer risk.” This article was written to address the growing concern surrounding the information that women suffering from endometriosis are at increased…

Key Points Lay Summary

EFA Medical Conference 2017: "Ovarian Cancer" Presentation by  Dr. Jeannine Villella

EFA Medical Conference 2017: By Kasthuri Nair

Dr. Jeannine Villella, the Chair of Gynecologic Oncology in the Department of OBGYN at Lenox Hill, presented at the 2017 EFA Medical Conference. Her presentation was titled “Ovarian Cancer, ” and she discussed the similarities, differences, and links between ovarian…

Key Points Lay Summary

Diseases that Coexist with Adenomyosis and Endometriosis

Diseases that Coexist with Adenomyosis and Endometriosis By Kasthuri Nair

Adenomyosis, defined by endometrial glands and stroma found within the muscular uterine wall, and endometriosis are two common gynecological diseases that are similar pathologically and symptomatically. Choi et al. recently conducted a study where they hoped to determine the prevalence…

Key Points Lay Summary

The Deregulated Molecular Functions Involved in Malignant Transformation of Endometriosis to Endometriosis-Associated Ovarian Carcinoma

The Deregulated Molecular Functions Involved in Malignant Transformation of Endometriosis to Endometriosis-Associated Ovarian Carcinoma By Dr. Youngran Park

Endometriosis-associated ovarian cancer (EAOC) is postulated to be transformed from endometriosis. Though different deregulated functional areas were proposed accounting for the pathogenesis of EAOC transformation, there is a lack of data-driven analysis to prove this. To understand the EAOC pathogenesis…

Key Points Lay Summary

Can Ovarian Stimulation Increase Endometrioma Volume?

Can Ovarian Stimulation Increase Endometrioma Volume? By Kasthuri Nair

Seyhan et al. recently published a paper titled “Do endometriomas grow during ovarian stimulation for assisted reproduction? A three-dimensional volume analysis before and after ovarian stimulation” in Reproductive BioMedicine Online. The authors initially believe that ovarian stimulation, often used in…

Key Points Lay Summary

EFA Medical Conference 2017: Welcome Presentation by Dr. Tamer Seckin

EFA Medical Conference 2017: Welcome Presentation by Dr. Tamer Seckin By Kasthuri Nair

The first part of the Endometriosis Foundation of America’s 2017 Medical Conference delved into the mission and history of the Endometriosis Foundation of America. The first presenter was Dr. Tamer Seckin, a renowned surgeon, and gynecologist who is also the…

Key Points Lay Summary

An update of estrogen receptors on human disease

An update of estrogen receptors on human disease By Yu Yu

Estrogens and its receptors influence numerous human physiological processes. Two estrogen receptors exist, including estrogen receptor α (ERα) and ERβ. Hence, it is essential to elucidate the functions of these receptors in healthy and diseased states. This is particularly important…

Key Points Lay Summary

Is there any association between menstrual pain and ovarian cancer?

Is there any association between menstrual pain and ovarian cancer? By Yu Yu

Inflammation may be important in ovarian carcinogenesis. Epidemiological studies show that inflammatory conditions such as endometriosis and pelvic inflammatory disease have been associated with an increased risk of ovarian cancer, while regular use of non-steroidal anti-inflammatory drugs has reduced associated…

Key Points Lay Summary

Ovarian Reserve Depletion is not Time Sensitive

Ovarian Reserve Depletion is not Time Sensitive By Kasthuri Nair

The European Journal of Obstetrics & Gynecology and Reproductive Biology recently published a paper titled “Is endometrioma-associated damage to ovarian reserve progressive? Insights from IVF cycles.” This publication by Benaglia et al. examines the controversial relationship between endometriosis and ovarian…

Key Points Lay Summary

New Approach could help Preoperative Differentiation of Endometriosis and Cancer

New Approach could help Preoperative Differentiation of Endometriosis and Cancer By Özge Özkaya

Researchers in Japan identified some radiological parameters that could be used to differentiate between endometriosis-associated ovarian cancer (EAOC) and a particular type of benign ovarian endometriosis (OE), making it easier for doctors to offer the right treatment to women who…

Key Points Lay Summary

Serum AMH Levels Play an Important Role In Fertility Preservation

Serum AMH Levels Play an Important Role In Fertility Preservation By Kasthuri Nair

One of the options available for women who suffer from endometriosis related infertility is cryopreservation. This option is only viable if the woman in question does not suffer from the low ovarian reserve. Garavaglia et al. suggest using pre-surgical serum…

Key Points Lay Summary

Endometriosis and Ovarian Cancer Risk

Endometriosis and Ovarian Cancer Risk By Yu Yu

Ovarian cancer prevalence in women with endometriosis is higher than the general population. It is often hypothesized that endometriosis-associated malignancies can occur from ovarian endometrioma. This systematic review by Taniguchi highlighted new insights on the relationship between endometriosis and ovarian…

Key Points Lay Summary

Ovarian Endometriomas vs Deep Infiltrating Endometriosis

Ovarian Endometriomas vs Deep Infiltrating Endometriosis By Yu Yu

Ovarian endometrioma (OMA) and deep infiltrating endometriosis (DIE) have been described as two disease entities, although they are both characterized by endometrial tissue located outside the uterus. As OMA and DIE look different histologically, it is puzzling what cause their…

Key Points Lay Summary

Reduced vascularization in ovarian endometriomas associated with less pain

Reduced vascularization in ovarian endometriomas associated with less pain By Yu Yu

Angiogenesis, i.e., the development of new blood vessels is believed to play an important role in endometriosis pathogenesis and symptoms. Endometriosis is associated and requires neovascularization to proliferate, invade surrounding normal structure in order to establish an endometriotic lesion. Ovarian…

Key Points Lay Summary

Is it Estrogen that Regulates Endometriosis Pain?

Is it Estrogen that Regulates Endometriosis Pain? By Yu Yu

Endometriosis-associated pain is a debilitating condition; however, it is surprising that the perceived pain has no correlation to the endometriosis extent. The mechanism that causes the pain is also poorly understood. Nerve growth factor is enhanced in endometriosis and may increase…

Key Points Lay Summary

Characteristics of Ovarian Endometriotic Cysts Could Help Determine Whether Endometrioma Will Reoccur

Characteristics of Ovarian Endometriotic Cysts Could Help Determine Whether Endometrioma Will Reoccur By Özge Özkaya

The features of ovarian endometriotic cysts could help predict whether endometrioma will re-occur in individual patients, according to a study published in the European Journal of Obstetrics and Gynecology. Predicting the risk of recurrence is important because it can help…

Lay Summary

Genetic Variations May Link Risk of Endometriosis and Ovarian Cancer

Genetic Variations May Link Risk of Endometriosis and Ovarian Cancer By Özge Özkaya

Variations in a gene called HNF1B could be linked to the risk of endometriosis, according to a study published in the medical journal Gynecologic Oncology. Previous studies had identified the same genetic variation as a risk factor for ovarian cancer.…

Lay Summary

Increased Oxidative Stress in Endometriosis may Be Linked to Higher Risk of Ovarian Cancer

Increased Oxidative Stress in Endometriosis may Be Linked to Higher Risk of Ovarian Cancer By Ezio Rosato

In the study that was published in the scientific journal Translational Oncogenomics, a group of researchers led by Dr. Hariyono Winarto from the Universitas Indonesia in Jakarta identified increased oxidative stress as one of the causes that might explain the…

Lay Summary