Promising potential research topic: diagnostic biomarkers for endometriosis

Promising potential research topic: diagnostic biomarkers for endometriosis By Nasuhi Engin Aydin

Dr. Toczek and collegues from the Department of Gynecology, Obstetrics and Oncological Gynecology of Medical University of Silesia in Katowice, Poland, have  published a review paper on possible diagnostic aid of cytokines in endometriosis. This review appears in May issue…

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Endometriosis and possible cardiovascular outcomes

Endometriosis and possible cardiovascular outcomes By Selma Oransay

A retrospective population-based cohort study from the Institute of Applied Health Research, University of Birmingham, Birmingham, the UK, investigated the long-term cardiovascular outcomes of women with endometriosis. The study included 279,759 women in total, 20,1% (>56.000) were patients with surgically…

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Time for noninvasive serum markers for endometriosis diagnosis

Time for noninvasive serum markers for endometriosis diagnosis By Nasuhi Engin Aydin

Dr. Onur Guralp and associates from Germany and Turkey published their results on serum markers predicting endometriosis in the "Journal of Obstetrics and Gynaecology".   Still, in 21st-century medicine, doctors can not diagnose endometriosis using biochemical serum markers. Proposed serum markers…

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Fixing holes: prevention and treatment of complications - Jon Einarsson, MD, MPH

Fixing holes: prevention and treatment of complications - Jon Einarsson, MD, MPH By Selma Oransay

Dr. Einarsson shared his operating room video screens during his speech for discussing four major complications (ureter, bladder,  bowel, and vascular) of endometriosis surgery and the ways to repair them. Fixing the ureter damage: Endometriotic nodules may settle on the tract…

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Discrepancies between racial/ethnic groups and choice of hysterectomy procedures

Discrepancies between racial/ethnic groups and choice of hysterectomy procedures By Nasuhi Engin Aydin

Dr. Pollack and associates from Washington University, St.Louis, made multistate research regarding the patient profile in hysterectomies and published their results in the 2019 December issue of "The Journal of Minimally Invasive Gynecology". The most frequently performed nonobstetric surgery in…

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The predictors for sexual dysfunction in infertile women with endometriosis

The predictors for sexual dysfunction in infertile women with endometriosis By Hale Goksever Celik

Endometriosis is a disease defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. Its incidence ranges up to 10% of reproductive-aged women. The most common symptoms in these women are chronic pelvic pain, dyspareunia, and…

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Surgical approach to rectovaginal endometriosis.

Surgical approach to rectovaginal endometriosis. By Selma Oransay

Recto-vaginal endometriosis incidence is estimated at 3.8%-37% among women with endometriosis and when it exists it's a part of deeply infiltrated endometriosis, thus advance stage endometriosis. Raimondo et al. from the Department of Obstetrics and Gynecology of the University of…

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Endometriosis and atherosclerotic cardiovascular disease

Endometriosis and atherosclerotic cardiovascular disease By Selma Oransay

Endometriosis and atherosclerotic cardiovascular disease show the same pathologic mechanism in terms of endothelial dysfunction. Tan et al. from the Department of Obstetrics and Gynecology, the University of British Columbia, Vancouver, Canada reviewed the literature aiming to determine whether women…

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Endometriosis and the quality of life

Endometriosis and the quality of life By Selma Oransay

Recent developments of technics and improvement of skill in the laparoscopic field increased the courage of clinicians to attempt early and multiple diagnostic operations on endometriotic patients. Vanuccini et al. from NEUROFARBA, University of Florence, Florence, Italy recently published their…

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Clinical trial for the use of oral lactobacillus on endometriosis pain severity

Clinical trial for the use of oral lactobacillus on endometriosis pain severity By Yu Yu

The standard treatment of endometriosis consists of surgery and hormonal based treatment. There is evidence for the efficacy of these types of treatment, although their side effects remain a critical consideration for women. Based on molecular studies, changes in the…

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Atherosclerotic cardiovascular disease and endometriosis

Atherosclerotic cardiovascular disease and endometriosis By Nasuhi Engin Aydin

Dr. Omur Taskin and associates from British Columbia, Canada, have recently published a review regarding the potential link between atherosclerotic cardiovascular disease (ASCVD) and endometriosis in The Journal of Minimally Invasive Gynecology. Atherosclerotic cardiovascular disease is the leading cause of…

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Mortality of 49956 midlife women with surgically verified endometriosis

Mortality of 49956 midlife women with surgically verified endometriosis By Irem Onur

Saavalainen L. et al., from Finland recently published a retrospective large cohort study in the journal Human Reproduction, where they retrospectively examined the data of surgically verified endometriosis patients to find out if all-cause and the cause-specific mortality rate is…

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Early Developmental Gene May Play a Role in Endometriosis

Early Developmental Gene May Play a Role in Endometriosis By Özge Özkaya

An early developmental gene called twist may encourage the connective tissue cells of the lining of the uterus to change from being epithelial to being mesenchymal, so-called epithelial to mesenchymal transition (EMT).  Mesenchymal cells play important roles in biological processes…

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The coexistence deep infiltrating endometriosis and fibromyalgia

The coexistence deep infiltrating endometriosis and fibromyalgia By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The main symptoms of endometriosis which are dysmenorrhea, dyspareunia, and chronic pelvic pain impair the quality of life of these women. This disease may…

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Preoperative factors to predict unresponsiveness in women undergoing endometriosis surgery

Preoperative factors to predict unresponsiveness in women undergoing endometriosis surgery By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Despite extensive research, the optimal management of endometriosis still remains unclear. Several treatment options include analgesic medication, hormonal treatments, and surgical intervention. There is…

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Mistletoe as a Potential Candidate for Endometriosis Treatment

Mistletoe as a Potential Candidate for Endometriosis Treatment By Dr. Youngran Park

Endometriosis, one of the common benign gynecologic disorders, is defined as the ectopic presence of endometrial cells outside of the uterine cavity. Although the underlying mechanisms are not fully understood, the most accepted hypothesis is that endometrial cells pass through…

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Conservative Surgery May Be Sufficient to Halt the Development of Deep Endometriosis

Conservative Surgery May Be Sufficient to Halt the Development of Deep Endometriosis By Özge Özkaya

Deep endometriosis develops as a result of collective cell migration and nerve recruitment from surrounding organs, suggests a study published in the scientific journal Fertility and Sterility.   Collective cell migration is the biological process whereby a group of cells moves…

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Lipophilic Statins inhibit growth and invasiveness of human endometrial cells

Lipophilic Statins inhibit growth and invasiveness of human endometrial cells By Murat Osman

Endometriosis is a disease process whereby cells of the endometrium grow and invade structures outside of the uterus. Through recent research, it has been seen that endometriotic foci in women with endometriosis exhibit an altered phenotype that contributes to its…

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Does deep infiltrating endometriosis affect sexual activity?

Does deep infiltrating endometriosis affect sexual activity? By Dr. Youngran Park

Endometriosis is one of the most common gynecological diseases in women of reproductive age, and pelvic pain and infertility are the most frequent complications. There are three different type of endometriosis lesions; superficial lesions, deep lesions, and ovarian cysts. In…

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Programmed cell death 4 suppresses endometriosis by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway

Programmed cell death 4 suppresses endometriosis by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway By Dr. Youngran Park

Endometriosis is a kind of benign disease but shares many similar features with cancers, such as abnormal cell migration, invasion, and unrestrained growth. It has been known that some genes are expressed differentially in eutopic endometrium of EM patients compared…

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Multimodality imaging and clinicopathologic assessment of abdominal wall endometriosis

Multimodality imaging and clinicopathologic assessment of abdominal wall endometriosis By Irem Onur

Abdominal wall endometriosis is a rare clinical entity frequently diagnosed with a significant delay and easily misinterpreted despite multimodality imaging. In the study of Jaramillo-Cardoso et al. which has recently been published in the journal Abdominal Radiology, the clinical, multimodality…

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A Better Way to Diagnose Endometriosis?

A Better Way to Diagnose Endometriosis? By Özge Özkaya

Three proteins found in the blood and endometrial tissues could be used to determine the stage of endometriosis and the severity of painful periods according to a study published in the journal Current Medical Science. Evaluating the levels of these…

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A Balancing Act: How Endometriosis Invades the Body

A Balancing Act: How Endometriosis Invades the Body By Murat Osman

Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterine cavity. Ectopic endometrial tissues have been shown to have some features that mimic malignancy. For example, endometriosis can invade surrounding structures and attach to surfaces such…

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3,6-DHF suppresses the invasive properties of endometrial stromal cells through the Notch signaling

3,6-DHF suppresses the invasive properties of endometrial stromal cells through the Notch signaling By Dr. Youngran Park

Dr. Zhou group reported recently that 3,6-DHF can inhibit the development of EMT, migration, and invasion of endometrial stromal cells by inhibiting the Notch signaling pathway. Endometriosis is a condition in which the layer of tissue (glands and mesenchyme) that normally…

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Could the Sleep Hormone Treat Endometriosis?

Could the Sleep Hormone Treat Endometriosis? By Özge Özkaya

Melatonin blocks cell proliferation, invasion, and migration in both normal and endometriotic epithelial cells, according to a study published in the scientific journal Reproductive Biology and Endocrinology. Melatonin could, therefore, be a potential treatment for endometriosis  The formation and progression…

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Thoracic Endometriosis Syndrome (TES): Diagnosis by cytology of pleural effusion

Thoracic Endometriosis Syndrome (TES): Diagnosis by cytology of pleural effusion By Nasuhi Engin Aydin

Parikshaa Gupta and colleagues from Chandigarh, India report a case of thoracic endometriosis diagnosed primarily by pleural fluid cytology in a most recent article at Cytopathology. A 33-year-old female presented with a long history of recurrent bouts of chest pain…

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Endometriosis Development: Pathogenesis and genomics

Endometriosis Development: Pathogenesis and genomics By Selma Oransay

In this review recently published in the International Journal of Molecular Sciences, Baranow et al from Saint Petersburg, Russia,  hypothesize the existence of an endometriosis development genetic program (EMDP) that governs the origin of endometrium stem cells programmed for endometriosis; their transition…

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Commentary on major developments in the pathophysiology of endometriosis

Commentary on major developments in the pathophysiology of endometriosis By Nasuhi Engin Aydin

This commentary article by Dr. Warren G. Foster, from MacMaster University, Canada that appeared at Biology of Reproduction, is highly valuable for its leading role in endometriosis research. Although endometriosis is a common disease affecting up to 10% of women,…

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miRNAs, Could Be a Reliable Biomarker of Endometriosis

miRNAs, Could Be a Reliable Biomarker of Endometriosis By Özge Özkaya

miRNAs, small pieces of genetic material found in the blood could be used as a reliable marker to diagnose endometriosis, according to a study by U.S. researchers. They could also be used to follow the progression of the disease and…

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No Link Found Between Vitamin D and Endometriosis

No Link Found Between Vitamin D and Endometriosis By Kasthuri Nair

Buggio et al., a group of scientists from the Ospedale Maggiore Policlinico, Universita` degli Studi in Milan, recently published a paper in the Reproductive Sciences titled “25-Hydroxyvitamin D Serum Levels and Endometriosis: Results of a Case-Control Study.” The publication sought…

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Blood vessels formation in endometriosis

Blood vessels formation in endometriosis By Yu Yu

The endometrium undergoes dynamic changes during the menstrual cycle. Estrogen-driven angiogenesis is associated with the proliferative phase, and progesterone-driven vascular maturation occurs in the secretory phase. Hence, it is reasonable that the vascularization of endometriosis is also under complex regulation…

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A New VAS-based Diagnostic Tool for Interpreting Pain

A New VAS-based Diagnostic Tool for Interpreting Pain By Kasthuri Nair

The visual analog scale (VAS) is a diagnostic tool used by health care providers to evaluate chronic pain in women with endometriosis. In their publication titled “Minimal clinically important difference for pain on the VAS scale and the relation to…

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Endometriosis : A Whole Body Disease

Endometriosis : A Whole Body Disease By Kasthuri Nair

Endometriosis is a disease that impacts multiple parts of an individual’s body. Seminars in Reproductive Medicine recently published a paper by Alderman III et al. entitled “The Systemic Effects of Endometriosis” explores the various comorbidities that can affect individuals suffering…

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Ping-Chong-Jiang-Ni Formula: A Natural Treatment

Ping-Chong-Jiang-Ni Formula: A Natural Treatment By Kasthuri Nair

In the world of modern medicine, natural and herbal remedies are often under utilized. Liang et al. recently published an article in Evidence-Based Complementary and Alternative Medicine where they explored the benefits of using a Chinese Herbal Medicine to treat…

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Dienogest for endometriosis pain in clinical practice

Dienogest for endometriosis pain in clinical practice By Yu Yu

Dienogest is a synthetic progestogen that has been marketed as a medical treatment for endometriosis. Previous randomized controlled clinical trials have shown that it is effective in women with endometriosis at different stages of the disease. Given its recent introduction,…

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The Benefits of Primary Surgery

The Benefits of Primary Surgery By Kasthuri Nair

Ahmad, Hussin, and Ahmad recently conducted a cohort study, and they published the results within an article titled “An evaluation of the quality of life in women with endometriosis who underwent primary surgery: a 6-month follow-up in Sabah Women &…

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Cryoablation to Treat Abdominal Wall Endometriosis

Cryoablation to Treat Abdominal Wall Endometriosis By Murat Osman

Endometriosis of the abdominal wall (AWE) is often painful and requires hormone therapy or surgery for clinical management. Thus, non-invasive treatment options to help reduce pain and the progression of these lesions will help patients who suffer from this disease.…

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Ultrasound Ablation to Treat Endometriosis

Ultrasound Ablation to Treat Endometriosis By Murat Osman

Further Understanding: Deeply infiltrating endometriosis (DIE) often presents in the rectosigmoid colon in women with endometriosis and can be the major cause of gastrointestinal and pelvic symptoms. This preliminary study focuses on the utility of High-Intensity Focused Ultrasound (HIFU) in…

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