Is Your Surgeon Stressed?

Is Your Surgeon Stressed? By Özge Özkaya

Stress during endometriosis surgery among surgeons is greater than what they anticipate, according to a new study published in the scientific journal Acta Obstetricia et Gynecologica Scandinavica. The stress symptoms reported by surgeons start before surgery and is more common among…

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A herbal product has promising results in experimental endometriosis

A herbal product has promising results in experimental endometriosis By Nasuhi Engin Aydin

Neroli oil (bitter orange) is a nontoxic volatile substance from the flowers of Citrus aurantium that belongs to the Rutaceae family. This oil has notable anti-inflammatory effects besides potent antioxidant activity with 100% singlet oxygen scavenging activity. Contemporary pathophysiological views…

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Elevated iron levels in "endometriosis pathogenesis"

Elevated iron levels in By Selma Oransay

The presence of abnormal levels of iron and ferritin in endometriotic lesions is likely due to repeated bleeding episodes. When red blood cells break down, the iron content is released, which can cause inflammation leading to damage to surrounding tissues.…

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Endometriosis and Progesterone Resistance

Endometriosis and Progesterone Resistance By Selma Oransay

Progesterone resistance is the unresponsiveness of endometrium with subsequent dysregulation of the progesterone signaling pathway, and endometrial gene works. Progestins, on the other hand, are the first-line treatment choice, especially for long-term treatment of endometriosis. In the clinics, one-third of…

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​Integrative medical management of endometriosis

​Integrative medical management of endometriosis By Selma Oransay

This lecture entitled "Integrative Medical Management of Endometriosis" was presented by Dr. Pinar Kodaman, Director of the endoscopic reproductive surgery program and Assoc. Professor of Clinical ObGyn and Reproductive Sciences at the Yale School of Medicine. In addition to surgery which…

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This time it is good to have this stress: Endoplasmic reticulum stress and endometriosis.

This time it is good to have this stress: Endoplasmic reticulum stress and endometriosis. By Bahar Yuksel

Endometriosis is a hormone-based inflammatory disease. Cell-level therapeutic options are very popular when resistance to cell death capacity of endometriotic cells is on the table. In the review conducted by Hussein Riyadh Abdul Kareem Al‑Hetty et al, the authors summarized…

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Hypoxia and endometriosis: A review of mechanisms

Hypoxia and endometriosis: A review of mechanisms By Eylül GÜN

Various mechanisms have been suggested to explain the development of endometriosis lesions. One of these is hypoxia, which can induce changes in endometrial cells, but the exact mechanism is not yet clear. Zhou et al from China wrote a review…

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Scientific unfolding will lead new drug targets

Scientific unfolding will lead new drug targets By Nasuhi Engin Aydin

Drs. Dolmans and Donnez from academic institutions located in Brussels, Belgium, have published their comprehensive review on the current pathophysiological concepts in endometriosis with possible drug treatment potentials in the recent issue of a scientific journal named “Biomolecules”.  As a…

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Is endometriosis an oxidative stress-induced inflammation?

Is endometriosis an oxidative stress-induced inflammation? By Bahar Yuksel

The roots of endometriosis are still controversial, but the effects of inflammation and oxidative stress have been accepted by scientific authorities. In the review conducted by Lauren Clower et al, the studies about oxidative stress and endometriosis have been analyzed.…

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The role of oxidative stress on endometriosis symptomatology

The role of oxidative stress on endometriosis symptomatology By Bahar Yuksel

Endometriosis is not only a hormonal disease, but it is also an inflammatory illness provoked by hormones. In the review conducted by Hossein Ansariniya et al., from Iran, the relation between oxidative stress, free radicals, free iron, and the development of…

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Mindfullness Can Hep Reduce Endometriosis Pain

Mindfullness Can Hep Reduce Endometriosis Pain By Özge Özkaya

A brief mindfulness-based intervention can be useful in managing pain related to endometriosis and restoring patients’ psychological well-being, found a new study published in the European Journal of Pain. This finding contributes to the applicability of mindfulness-based interventions in people…

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Physical activity and exercise in reducing endometriosis symptoms

Physical activity and exercise in reducing endometriosis symptoms By Eylül GÜN

The treatment modalities to date on endometriosis have focused on the symptomatic relief and management of chronic pain. Hormonal suppression sometimes shows intolerable side effects and is known to lose effect after some time. Surgical interventions may not provide a…

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Envorinmental metals harmful for female reproductivity

Envorinmental metals harmful for female reproductivity By Selma Oransay

Heavy metals exposure in a wide range of ways is one of the main causes of increased infertility. According to the 2003 National Health Survey, nearly every pregnant woman in the USA is exposed to at least 43 hazardous chemicals…

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“Sirtuin-3” as a novel target in endometriosis pathogenesis

“Sirtuin-3” as a novel target in endometriosis pathogenesis By Eylül GÜN

The energy that is needed for a normal cell function is produced in the mitochondria. While producing this energy, a complex and cyclical process occurs with many proteins and enzymes. Enzymes such as glutamate dehydrogenase and succinate dehydrogenase play important…

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What causes distress in women with endometriosis?

What causes distress in women with endometriosis? By Eylül GÜN

Endometriosis is a disease that affects a woman’s life from many different aspects; emotionally, sexually, and physiologically. With the burden of the distress caused by the disease, most women suffer from anxiety and depression. This results in lower self-esteem and…

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The higher the cyst fluid iron concentration, the more severe the pain symptom for endometrioma

The higher the cyst fluid iron concentration, the more severe the pain symptom for endometrioma By Hale Goksever Celik

Endometriosis usually is encountered in three different forms: superficial peritoneal endometriosis, ovarian cysts (endometrioma) and deep infiltrating endometriosis. Endometrioma can be identified as cystic lesions consisting of dark brown endometrial fluid and are sometimes referred to as "chocolate cysts." The presence…

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The effects of endometriosis on life satisfaction.

The effects of endometriosis on life satisfaction. By Bahar Yuksel

Endometriosis is well-known for its debilitating effects on women suffering from it. In the review conducted by Masoumeh Namazi et al, the authors have collected studies searching for the wellbeing of women with endometriosis. They have analyzed 46 studies that…

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Antioxidant therapy for the endometriosis pain

Antioxidant therapy for the endometriosis pain By Selma Oransay

Ts the protective defense mechanism of cells, hence the destruction of balance between oxidants and antioxidants in our body is called "redox imbalance".  The major oxidants are reactive oxygen species (ROS) that are involved in multiple cellular processes by physiologically…

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Oxidative stress, reactive products, detoxification, endometriosis and pain

Oxidative stress, reactive products, detoxification, endometriosis and pain  By Ellen Tumimbang

Oxidative stress is one factor known to be involved in the pathogenesis, progression, and establishment of endometriosis in women.   During oxidative stress, excess reactive oxygen species as a secondary by-product of lipid peroxidation and reactive aldehyde including 4- hydroxynonenal…

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The "metabolome" of follicular fluid in deep infiltrating endometriosis

The By Yu Yu

Endometriosis encompasses three different phenotypes, being superficial endometriosis, deep infiltrating endometriosis (DIE), and ovarian endometrioma (OMA). The latter is the most severe form and has an unfavorable impact on ovarian function. Infertility associated with endometriosis has been linked to chronic…

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Could Cosmetics and Personal Care Products Increase the Risk of Endometriosis?

Could Cosmetics and Personal Care Products Increase the Risk of Endometriosis? By Özge Özkaya

The use of cosmetics and personal care products may be increasing the risk of endometriosis according to a study by Spanish researchers that was published in the journal "Environmental Research". This finding suggests that restricting the use of these products may…

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An animal model of endometriosis reveals stress related disturbed vitamin D - vitamin D receptor axis

An animal model of endometriosis reveals stress related disturbed vitamin D - vitamin D receptor axis By Nasuhi Engin Aydin

Lopez and colleagues from academic institutions of Puerto Rico published their experimental endometriosis findings on female rats regarding the effect of stress on vitamin D-vitamin D receptor systems and recently published their findings in "Reproductive Sciences". The group previously showed…

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Colorectal Deep Endometriosis Resection and Potential Complications

Colorectal Deep Endometriosis Resection and Potential Complications By Murat Osman

A severe clinical form of endometriosis, deeply infiltrating endometriosis (DIE) is characterized by more aggressive endometriotic lesions commonly involving deeper pelvic or gastrointestinal organs. It causes significant quality of life impairment and morbidity and is increasingly associated with infertility. When…

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Factors affecting the quality of life of women with endometriosis

Factors affecting the quality of life of women with endometriosis By Timur Seckin

Results from a new study suggest that the quality of life of women with endometriosis is significantly affected by their confidence to manage pain and their belief in the evolution of their condition. In this study, led by Rees M. et…

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Antioxidant Enzymes in Endometriosis

Antioxidant Enzymes in Endometriosis By Dr. Youngran Park

Recent attention has been focused on the effect of oxidative stress in the development of endometriosis. Especially, there are several studies regarding glutathione peroxidase (GPX), a major enzyme in removing various reactive oxygen species. In the field of infertility, the…

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Mental stress promotes mice endometriosis

Mental stress promotes mice endometriosis By Bahar Yuksel

Endometriosis is a disease for which pathogenesis and progression are not fully understood. Inflammation is one of the key candidates that might be related to the creation or progression of endometriosis. In the study conducted by Kawakita et al from…

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Oxidative stress leads to elevated cytokines, excessive structural damage and angiogenesis

Oxidative stress leads to elevated cytokines, excessive structural damage and angiogenesis By Yu Yu

Endometriosis is characterized by elevated intracellular reactive oxygen species, which is then believed to upregulate inflammatory cytokines. Reactive oxygen species also regulate the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which is closely linked with immune responses.…

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Fertility and Oxidative Stress

Fertility and Oxidative Stress By Yu Yu

One of the characteristics of endometriosis is oxidative stress caused by an imbalance between the production of reactive oxygen species and their resolution by antioxidants. Increased oxidative stress can lead to the damage of proteins, lipids, DNA and other molecules.…

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The Relationship Between Dyspareunia and Infertility in Endometriosis

The Relationship Between Dyspareunia and Infertility in Endometriosis By Selma Oransay

Wahl et al. from the Center of Pelvic Pain and Endometriosis British Columbia Women's Hospital, Vancouver, Canada studied with endometriotic patients suffering from dyspareunia who were referred to their center and built a cross-sectional study to investigate the relations between…

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Endometriosis and atherosclerotic cardiovascular disease

Endometriosis and atherosclerotic cardiovascular disease By Selma Oransay

Endometriosis and atherosclerotic cardiovascular disease show the same pathologic mechanism in terms of endothelial dysfunction. Tan et al. from the Department of Obstetrics and Gynecology, the University of British Columbia, Vancouver, Canada reviewed the literature aiming to determine whether women…

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The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis

The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis By Dr. Youngran Park

Endometriosis is a very common gynecological disorder affecting approximately 10% of reproductive-aged women, and it is known by the abnormal growth of endometrial stroma and glands outside the uterus. Though the pathogenesis of endometriosis is not clearly understood so far,…

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Does ovarian endometriosis affect oocyte quality?

Does ovarian endometriosis affect oocyte quality? By Dr. Youngran Park

Endometriosis is a very common gynecological disorder affecting women in their reproductive years. It is reported that patients with endometriosis have reduced implantation and pregnancy rates compared to healthy women. According to the various previous studies, the quality of the…

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Searching new biomarkers for endometriosis

Searching new biomarkers for endometriosis By Selma Oransay

This recent article published in Advances in Clinical Chemistry, is an overall summary of characteristics, physiopathological theories, diagnostic approaches and variety of biomarkers to diagnose endometriosis and penned by Coutinho et al. from Universidade Federal de Juiz de Fora, Belo Horizonte,…

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The relationship between periodontal disease and endometriosis

The relationship between periodontal disease and endometriosis By Irem Onur

Thomas et al. have recently studied the association between endometriosis and periodontal disease which may share a common pathogenesis, and have published it in the Journal of Human Reproductive Sciences. The authors screened a total of50 women; 25 with and 25…

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An overlooked symptom of endometriosis: Fatigue

An overlooked symptom of endometriosis: Fatigue By Timur Seckin

A majority of endometriosis patients experience fatigue. This is according to a multicenter study conducted by a group of researchers from Switzerland, Germany, and Austria. Fatigue, and feeling spoonie, may be a symptom of endometriosis affecting the daily activities and…

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Is Physical Exercise Effective in Endometriosis?

Is Physical Exercise Effective in Endometriosis? By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial tissue outside the uterine cavity. Dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility are mostly encountered symptoms of endometriosis. Although there are several theories explaining the pathogenesis of endometriosis, the exact pathogenesis still has…

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Pain and emotion regulation predict health-related quality of life

Pain and emotion regulation predict health-related quality of life By Deniz Kocas

Studies have established that pain in endometriosis is negatively correlated with HRQL and that endometriosis is associated with psychological problems, anxiety, depression, distress and poor coping ability. It has been observed that some mental conditions associated with endometriosis are modulated…

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Vitamin C supplementation in the patients with endometriosis undergoing in vitro fertilization-embryo transfer

Vitamin C supplementation in the patients with endometriosis undergoing in vitro fertilization-embryo transfer By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Women having endometriosis present with dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Thus, infertility remains a significant problem for women with endometriosis. Endometriosis is…

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“Free butterflies will come out of these deep wounds”: A grounded theory of how endometriosis affects women’s psychological health

“Free butterflies will come out of these deep wounds”: A grounded theory of how endometriosis affects women’s psychological health By Deniz Kocas

Researchers from the Catholic University of Milan and the University of Milan note in Journal of Health Psychology that although qualitative research describes the negative impact of endometriosis on quality of life and psychological well-being, studies that analyze individual differences…

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Oxidative Stress and Endometriosis

Oxidative Stress and Endometriosis By Murat Osman

Endometriosis is a disease characterized by ectopic endometrial tissue outside the endometrium and is associated with a background of a chronic inflammation. Recent studies have aimed to elucidate the inflammatory mediators involved in endometriotic lesions by studying immune cell interactions,…

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N-acetyl cysteine, alpha lipoic acid and bromelain improved endometriosis-associated pelvic pain

N-acetyl cysteine, alpha lipoic acid and bromelain improved endometriosis-associated pelvic pain By Yu Yu

Oxidative stress has been implicated in many processes that lead to the development and progression of endometriosis. Typically, women with endometriosis have to endure pelvic pain which negatively impacts their quality of life. Pelvic pain can be chronic and related…

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Detecting endometriosis using peripheral blood

Detecting endometriosis using peripheral blood By Yu Yu

Laparoscopic visualization of endometriotic lesions with histological confirmation is the gold standard for the diagnosis of endometriosis. However, this diagnostic procedure, due to the need for laparoscopy and variability of disease/symptoms, can have a major delay up to 8-10 years…

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A Doctor's Guide to Making Endometriosis Less Scary

A Doctor's Guide to Making Endometriosis Less Scary By Kasthuri Nair

Canis, Bourdel, and Chauvet, doctors from CHU Estaing, recently published an article titled “Endometriosis: frightening the patients is not an acceptable alternative to inadequate surgical management and or pathophysiology ignorance” in Fertility and Sterility. Their paper delineated proper health practices…

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Expert discussion on mechanisms of endometriosis development and progression

Expert discussion on mechanisms of endometriosis development and progression By Yu Yu

Several mechanisms have been proposed to explain the occurrence and worsening of endometriosis. Classically, it is believed that retrograde menstruation causes endometriosis. However, the presence of endometriosis in newly menarcheal or pre-menarcheal girls cannot fully explain this early onset endometriosis.…

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Another Marker to Predict the Outcome of IVF for Women with Endometriosis

Another Marker to Predict the Outcome of IVF for Women with Endometriosis By Özge Özkaya

AOPPs or advanced oxidative protein products may be new markers to predict egg quality and the outcomes of IVF in infertile women with endometriosis according to a study published in the journal Experimental and Therapeutic Medicine. This finding suggests that anti-oxidative treatments…

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Hair Cortisol Levels are Higher in Women Suffering from Endometriosis

Hair Cortisol Levels are Higher in Women Suffering from Endometriosis By Kasthuri Nair

Aken et al. recently published a piece in Psychoneuroendocrinology titled “Hair cortisol and the relationship with chronic pain and quality of life in endometriosis patients.” This publication discussed a study that analyzed hair cortisol levels in women with and without endometriosis. Hair cortisol levels…

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A Potential New Target for the Treatment of Endometriosis

A Potential New Target for the Treatment of Endometriosis By Özge Özkaya

A protein called STIP1 could be facilitating the migration of endometrial tissue outside the uterus, therefore, leading to endometriosis according to a study by Taiwanese researchers. The protein could, thus, be used as a potential therapeutic target for endometriosis.  For…

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Endometriosis pathogenesis through the lens of reactive oxygen species

Endometriosis pathogenesis through the lens of reactive oxygen species By Yu Yu

Oxidative stress caused by reactive oxygen species is an essential factor in endometriosis pathogenesis. The harmful effects of reactive oxygen species have been implicated in many diseases, although the multiple biological changes caused is unclear especially in endometriosis. The article…

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Stress affects endometriosis negatively

Stress affects endometriosis negatively By Demet Candaş Green

Stress contributes to many chronic health problems – endometriosis is one of them. Given that women with endometriosis are under more stress and pain, often with the added stress of infertility, it is important to understand the relationship between stress…

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Endometriosis and Oxidative Stress

Endometriosis and Oxidative Stress By Dr. Youngran Park

The etiology of endometriosis is still unclear. However, it is now widely accepted that oxidative stress, defined as an imbalance between reactive oxygen species (ROS) and antioxidants, may be implicated in the pathophysiology of endometriosis causing a general inflammatory response…

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A Two-Wave Molecular Mechanism for Endometriosis Disease Progression

A Two-Wave Molecular Mechanism for Endometriosis Disease Progression By Kasthuri Nair

Kobayashi et al. recently published a review paper in Molecular Medicine Reports titled “Pathogenesis of endometriosis: The role of initial infection and subsequent sterile inflammation,” which discusses at length the role of non-specific bacterial infection and sterile inflammation in the…

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Endometriosis and Psychological Health: Butterflies from Deep Wounds

Endometriosis and Psychological Health: Butterflies from Deep Wounds By Kasthuri Nair

Endometriosis is a grueling disease in every sense of the word; however, most of the discussions center on the physical manifestations of the disease. Facchin et al. veer from the beaten path and examine the impact endometriosis have on a…

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Agents Causing Red Blood Cell Lysis Worsens Endometriosis

Agents Causing Red Blood Cell Lysis Worsens Endometriosis By Kasthuri Nair

Endometriosis is a painful disease characterized by inflammation and the presence of pro-oxidation factors. These pro-oxidation factors are also released when red blood cells (RBCs) lyse. A paper titled “Dapsone hydroxylamine-mediated alterations in human red blood cells from endometriotic patients”…

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New Molecular Targets for the Treatment of Endometriosis-Associated Pain

New Molecular Targets for the Treatment of Endometriosis-Associated Pain By Ezio Rosato

The study identifies potential new targets for alleviating chronic pelvic pain that afflicts many women with endometriosis. A new study published in the scientific journal Redox Biology shows that molecules called microRNAs could be a potential new target to combat…

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Increased Oxidative Stress in Endometriosis may Be Linked to Higher Risk of Ovarian Cancer

Increased Oxidative Stress in Endometriosis may Be Linked to Higher Risk of Ovarian Cancer By Ezio Rosato

In the study that was published in the scientific journal Translational Oncogenomics, a group of researchers led by Dr. Hariyono Winarto from the Universitas Indonesia in Jakarta identified increased oxidative stress as one of the causes that might explain the…

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