Exploring a bonafide biomarker to predict endometriosis

Exploring a bonafide biomarker to predict endometriosis By Eylül GÜN

Endometriosis is a complex disease affecting many women in the reproductive age group. As it is important to figure out the mechanisms responsible for the disease, it is also crucial to identify biomarkers that can be used in the diagnosis…

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Does exercise have an effect on pain perception in women with endometriosis?

Does exercise have an effect on pain perception in women with endometriosis? By Hale Goksever Celik

Endometriosis is an inflammatory disease causing pain symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain, and also infertility. Several medical and surgical treatment options have been developed to improve quality of life of these women. Despite extensive research, the optimal…

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Endometrial epithelial stem/progenitor cells have links to endometriosis with potential therapeutic research aspects

Endometrial epithelial stem/progenitor cells have links to endometriosis with potential therapeutic research aspects By Nasuhi Engin Aydin

Dr. Cousins with colleagues from Australia and the USA published their review paper on a not well-known subject, the epithelial stem/progenitor cells of the endometrium. This interesting paper is recently published in the scientific journal named "Frontiers in Cell and Developmental…

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Endometriosis and the risk of Systemic lupus Erythematosus: A report from Taiwan

Endometriosis and the risk of Systemic lupus Erythematosus: A report from Taiwan By Selma Oransay

Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage that affects mostly women, with an M:F ratio of 1:9. Recent evidence has also shown that endometriosis is…

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"Complement" of immune system and endometriosis therapeutics

By Yu Yu

The complement system is part of the body’s immune system, and plays integral roles in the recognition and clearance of pathogens, apoptotic and necrotic cells. It is composed of over 50 proteins with soluble activation precursor components, regulators and cell…

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The origin of macrophages determines the fate of endometriosis

The origin of macrophages determines the fate of endometriosis By Yu Yu

Macrophages are diverse cells. They can present in all tissues of the body to perform crucial functions in immunity, homeostasis, repair and many more. Macrophages change their role depending on signals from their environment, and can therefore have a variety…

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The role of hormonal treatment after endometriosis surgery

The role of hormonal treatment after endometriosis surgery By Bahar Yuksel

Postoperative hormonal suppression after endometriosis surgery still does not have a uniform approach. The meta-analysis study conducted by Zakhari et al. aimed to find a significant answer regarding this burden. They analyzed the database systems including MEDLINE, Embase, Cochrane CENTRAL,…

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Endometriosis and Inflammation: How to Treat it?

Endometriosis and Inflammation: How to Treat it? By Özge Özkaya

Women with endometriosis have systemic and localized inflammation within eutopic and ectopic endometrial tissues found in a study published in the "American Journal of Reproductive Immunology". More importantly, the study also found that the inflammation caused by the disease could…

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Segmental bowel resection could be predicted using MRI in patients with rectal endometriosis

Segmental bowel resection could be predicted using MRI in patients with rectal endometriosis By Hale Goksever Celik

The rectum and recto-sigmoid junction are the preferential localisations of bowel endometriosis. The three main surgical approaches are shaving, disc excision, and segmental resection. It is very important to decide the most appropriate surgical method preoperatively and to plan accordingly. …

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Stem cell and exosome therapy

Stem cell and exosome therapy By Dr. Youngran Park

These days, two experimental methods, stem cell, and exosome therapy are getting more attention. Stem cell therapy has shown promising effects in regenerative medicine, including myocardial infarction, nervous system impairment, retinal damage, and liver diseases. Recent studies showed that stem…

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Woof Woof – Bone marrow cells are coming

Woof Woof – Bone marrow cells are coming By Yu Yu

Bone marrow contains cells that can travel to multiple organ sites and differentiate into specific tissue cells. Bone marrow-derived stem cells have also been associated with the pathogenesis of endometriosis. These cells can affect epithelial and stromal cell regeneration both…

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Endometriotic mesenchymal stem cells may promote endometriosis

Endometriotic mesenchymal stem cells may promote endometriosis By Yu Yu

The cause of endometriosis is still debatable. Many researchers have accepted that retrograde menstruation, where the endometrial fragments released during menstruation attach and colonize the ectopic locations, is the most plausible reason. However, the numbers just do not add up.…

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Fallopian tubes and endometriosis

Fallopian tubes and endometriosis By Selma Oransay

There are multiple theories to explain the pathogenesis of endometriosis, among which the most popular one is Sampson's retrograde menstruation theory. The role of endometrial stem cells/progenitors are widely studied to support the origin of ectopic lesions in recent decades.…

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Racial and ethnic disparities and women health

Racial and ethnic disparities and women health By Selma Oransay

The well documented racial and ethnic disparities in Obstetrics and Gynecology in the US make available to use them as an indicator of implicit bias in giving unequal health and care service to minorities. Dr. Bryant from Massachusetts General Hospital,…

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White blood cell neutrophils link to immunosuppressive environment in ovarian endometrioma

White blood cell neutrophils link to immunosuppressive environment in ovarian endometrioma By Yu Yu

Recently the contribution of neutrophils to the pathogenesis of endometriosis has been suggested. Several observations fuelled this suggestion, such as the accumulation of neutrophils in the peritoneal fluid of ovarian endometriosis; neutrophil extracellular traps were found in the peritoneal fluid of…

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New Insights on Infertility and Low Success Rates of Assisted Reproduction in Women with Endometriosis

New Insights on Infertility and Low Success Rates of Assisted Reproduction in Women with Endometriosis By Özge Özkaya

The fluid surrounding immature eggs waiting to mature and be fertilized by a sperm to lead to pregnancy is different in women with endometriosis compared to those without, according to a study published in Molecular Biology Reports. This could explain,…

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Early Life Factors for Endometriosis

Early Life Factors for Endometriosis By Dr. Youngran Park

Endometriosis affects approximately 10% of reproductive-aged women. Despite the significant impact, the etiology of endometriosis is still unclear. A recent systematic review of 15 studies of adolescents found that overall 65% of girls undergoing laparoscopic investigation were diagnosed with endometriosis.…

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The prevalence and severity of endometriosis today

The prevalence and severity of endometriosis today By Irem Onur

Ghiasi M. et al., a group of researchers from the USA, presented a comprehensive review of the prevalence, incidence, and stage of endometriosis worldwide as reported over the past 30 years. Researchers performed a search in four databases, including PubMed,…

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The association between endometriosis and ectopic pregnancy

The association between endometriosis and ectopic pregnancy By Hale Goksever Celik

Endometriosis is a chronic inflammatory disease with a broad spectrum of symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain and fertility problems. It has been understood in the light of scientific evidence that endometriosis is also associated with other poor…

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CXCR4 or CXCR7 antagonists as novel therapies for endometriosis

CXCR4 or CXCR7 antagonists as novel therapies for endometriosis By Dr. Youngran Park

Endometriosis is a common, estrogen-dependent chronic inflammatory disorder. It affects approximately 5-10% of reproductive-aged women and 20-50% of infertile women. Endometriosis also has a significant social and psychological impact on the lives of women. Despite such a significant burden, there…

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A comprehensive review on the etiopathogenesis of endometriosis

A comprehensive review on the etiopathogenesis of endometriosis By Nasuhi Engin Aydin

Endometriosis, being a heterogeneous disease has a highly complex etiopathogenesis.  A multicenter comprehensive review on this important subject from Italy, Germany, and the USA by Lagana and associates, was recently published in the "International Journal of Molecular Sciences" an open-access journal. Computerized…

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Surgery and the endometriosis associated-pain: A systematic review

Surgery and the endometriosis associated-pain: A systematic review By Selma Oransay

The surgical approach for pelvic pain-related to endometriosis depends on the stage and the type of the endometriotic lesion and ranging from ablation and the excision of the lesions to radical surgery as hysterectomy with removal of ovaries and presacral…

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Immune environment of endometriosis

Immune environment of endometriosis By Yu Yu

The results from the past decade of research have shown that an altered pro-inflammatory immune environment in endometriosis is believed to contribute to the pathophysiology of the disease. Because of changes in the immune microenvironment in the disease state, the…

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A rigorous literature review on endometriosis

A rigorous literature review on endometriosis By Irem Onur

Bulun SE. et al., from Feinberg School of Medicine, Northwestern University, Chicago, conducted a rigorous literature review on endometriosis. This outstanding review by Dr. Bulun et al. addresses the definition, remarkable medical features, clinically useful research findings, prevalence and distribution,…

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Heme impairs macrophage phagocytosis

Heme impairs macrophage phagocytosis By Yu Yu

Heme is an iron-containing molecule that carries oxygen in the blood and also serves many essential biological proteins. It is released from ruptured erythrocytes during hemolysis. If not chelated, heme can cause harmful oxidative damage and inflammation. Thus, heme is…

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Control on endometriosis progression by a "tyrosine kinase inhibitor"

Control on endometriosis progression by a By Irem Onur

B cells, which are important players of the immune system, are increased in the blood and peritoneal cavity of endometriosis patients. Activation of B cells and the presence of anti-endometrial autoantibodies have been also been described in women with endometriosis,…

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The reason for lower BMI and less body fat in women with endometriosis.

The reason for lower BMI  and less body fat in women with endometriosis. By Selma Oransay

Zolbin et al. from the Department of Obstetrics and Gynecology of Yale School of Medicine, New Haven, USA, recently published the results of their prospective controlled research on adipocyte alterations in endometriosis, in the journal "Reproductive Biology and Endocrinology". Endometriosis can…

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Endometriosis and nuclear receptors

Endometriosis and nuclear receptors By Dr. Youngran Park

It is well recognized that endometriosis is a steroid-dependent disorder. In endometrial stromal cells, progesterone regulates retinoic acid production and action. Retinoids also act via a number of nuclear receptors (NRs) and are involved in normal endometrial function and endometriosis. Estrogen…

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Correlation between Treg cells and peritoneal lesions in women with ovarian endometrioma

Correlation between Treg cells and peritoneal lesions in women with ovarian endometrioma By Yu Yu

It is increasingly suggested that defective immune response is responsible for the survival and development of ectopic endometrial cells into endometriosis. In women with endometriosis, the immune system fails to create an inflammatory process that destroys endometrial cells at the…

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A newly found relationship between estrogen signalling and immune dysregulation in endometriosis

A newly found relationship between estrogen signalling and immune dysregulation in endometriosis By Yu Yu

It is believed that endometriosis progression is "at least partly" due to dysregulation of immune cells resulting in the poor clearance of ectopic endometrial debris. In particular, aberrant macrophage function was found to be important in the establishment of endometriosis, since…

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Anti-inflammatory cytokines: a new horizon in endometriosis with possible clinical relevance

Anti-inflammatory cytokines: a new horizon in endometriosis with possible clinical relevance By Nasuhi Engin Aydin

Scientists led by Dr. Li from Shangai PRC, have made a comprehensive review of anti-inflammatory cytokines related to the pathogenesis of endometriosis in a recent issue of Cellular and Molecular Life Sciences.    Inflammation is important in the pathogenesis of endometriosis,…

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Menstrual blood-derived stem cells

Menstrual blood-derived stem cells By Selma Oransay

Chen et al.  from the Center of Diagnosis and Treatment of İnfectious Disease, Zhejiang University, China penned this recent review in the Journal of Stem Cell Research Therapy which is presenting the clinical potential of MenSCs (Menstrual blood-derived stem cells). …

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Local inflammation and disease severity in endometriosis

Local inflammation and disease severity in endometriosis   By Yu Yu

During inflammation, immune cell receptors recognize endogenous molecules called danger-associated molecular patterns (DAMPs) or ‘alarmins’. This process reflects tissue damage and is mediated upon cell death in the condition of strong inflammation. HMGB1 and IL-33 are important DAMP molecules. Recently,…

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New scientific evidence supporting robotic surgical approach to ureteric endometriosis

New scientific evidence supporting robotic surgical approach to ureteric endometriosis By Nasuhi Engin Aydin

Surgical treatment of ureteral endometriosis aims to relieve urinary obstruction besides preserving renal functions. In accomplishing these, the best method of surgical approach is still unclear. Andrea Giannini and her colleagues from the University of Pisa, Italy conducted a retrospective…

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Is the mystery for progression of endometriosis hiding out in abnormally located endometrial cells?

Is the mystery for  progression of endometriosis hiding out in abnormally located endometrial cells? By Selma Oransay

This prospective study was conducted by Hapangama et al. in Research İnstute of the University of Liverpool, UK, and the results have recently published in the Journal of Human Reproduction. The authors hypothesized that abnormally located endometrial basalis-like (SSEA1/nSOX9+)cells could be contributing to…

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Endometriosis-associated pain control by contraceptive implant or intrauterine system

Endometriosis-associated pain control by contraceptive implant or intrauterine system By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The most common symptoms are dysmenorrhea, dyspareunia, and chronic pelvic pain, all of which affect the quality of women’s lives. Several studies investigating the…

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Immune dysregulation in endometriosis

Immune dysregulation in endometriosis By Yu Yu

The connection between endometriosis and the immune system has long been proposed. However, to date, there is no real consensus on whether immune adaptations actually facilitate endometriotric lesion progression or they are a consequence of endometriosis re-occurrence. Thus, this article…

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Another Study Suggesting That Endometriosis May Be a Disease Associated With Immune System Dysfunction

Another Study Suggesting That Endometriosis May Be a Disease Associated With Immune System Dysfunction By Özge Özkaya

An immune system protein called TGF-β in the peritoneal fluid or fluid that lubricates the lining of the abdominal wall and pelvic cavity may be creating an environment favorable for the formation of endometrial lesions. This is according to a…

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Cosmetics and some household products could be responsible for worsening endometriosis.

Cosmetics and some household products could be responsible for worsening endometriosis. By Selma Oransay

A controlled clinical study recently published in the Journal of Human Reproductive Sciences,  composed by Nazir et al. from the University of Health Sciences, Lahore, Pakistan. The study compared the blood diethyl hexyl phthalate (DEHP) levels of fifty infertile women laparoscopically diagnosed…

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Angiotensin receptor MAS1 may have a role in the pathogenesis of endometriosis

Angiotensin receptor MAS1 may have a role in the pathogenesis of  endometriosis By Nasuhi Engin Aydin

Takahiro Nakajima and colleagues from Nihon University School of Medicine, Tokyo, Japan report their novel findings on Angiotensin receptor MAS1 in the pathogenesis of endometriosis in Gynecologic and Obstetrics Investigation. The renin-angiotensin system (RAS) is an activation cascade playing a…

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Questionnaire based evaluation of sexual life after laparoscopic surgery for endometriosis

Questionnaire based evaluation of sexual life after laparoscopic surgery for endometriosis By Deniz Kocas

Researchers from Denmark note that laparoscopic surgery is being increasingly used for the treatment of endometriosis due to its safety and effectiveness. However, treatment success is often evaluated through follow-up on the experience of pain, leaving other important aspects of…

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Can we predict the complexity of laparoscopic surgery by ultrasound?

Can we predict the complexity of laparoscopic surgery by ultrasound? By Selma Oransay

This is a multicentric, retrospective cohort study recently published in the Journal of Minimally Invasive Gynecology by Tompsett et al. in which the results of the transvaginal ultrasonographic examinations (TVS) are compared to the results of the laparoscopic operations performed…

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Endometriosis Development: Pathogenesis and genomics

Endometriosis Development: Pathogenesis and genomics By Selma Oransay

In this review recently published in the International Journal of Molecular Sciences, Baranow et al from Saint Petersburg, Russia,  hypothesize the existence of an endometriosis development genetic program (EMDP) that governs the origin of endometrium stem cells programmed for endometriosis; their transition…

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Altered Immunity in Endometriosis

Altered Immunity in Endometriosis By Yu Yu

In recent years, there has been increased attention on the role of immune system in endometriosis development. Normally, immune reactions are supposed to destroy endometrial cells seeding in the peritoneal cavity. Nonetheless, in endometriosis, these cells are able to evade,…

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Therapeutic strategies involving uterine stem cells in reproductive medicine

Therapeutic strategies involving uterine stem cells in reproductive medicine By Murat Osman

Stem cells are undifferentiated cells that often serve to regenerate tissue in states of injury or apoptosis. The endometrium has progenitor cells that replace tissue lost after each menstrual cycle. It has been postulated that excessive stem cell recruitment to…

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Abnormal Regulation of Pathways Seen in Endometriosis

Abnormal Regulation of Pathways Seen in Endometriosis By Kasthuri Nair

Sikora et al., a team from the Medical University of Silesia in Katowice, published a study in the Archives of Gynecology and Obstetrics titled “The role of complement components C1q, MBL and C1 inhibitor in the pathogenesis of endometriosis.” It has been said that complement system…

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Stem cell therapy for the premature ovarian failure 

Stem cell therapy for the premature ovarian failure  By Dr. Youngran Park

Premature ovarian failure (POF) is one of the common disorders found in women. The cause of POF is not fully known, but various factors have been suggested. In genetically, X and autosomes chromosome abnormalities could result in some POF. The…

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Picture This: 8K UHD Television System for Endometriosis Surgery

Picture This: 8K UHD Television System for Endometriosis Surgery By Kasthuri Nair

This case report by Aoki et al. was published in the journal "Videosurgery and Other Miniinvasive Techniques" under the title “Effect of an 8K ultra-high-definition television system in a case of laparoscopic gynecologic surgery.” In this publication, the authors delineated…

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Mechanism for Migration of Endometriosis Cells in the Body

Mechanism for Migration of Endometriosis Cells in the Body By Kasthuri Nair

Li et al. recently published a paper in Stem Cells titled “Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis.” This article seeks to understand the mechanisms underlying the migration of endometriosis. The authors initially hypothesize that endometriosis-derived mesenchymal stem cells…

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Endocrine and inflammatory factors in current understanding of endometriosis

Endocrine and inflammatory factors in current understanding of endometriosis By Yu Yu

There are three forms of endometriosis: peritoneal, ovarian, and deep infiltrating. All three forms consist of endometriotic lesions containing endometrial glands, stroma, nerves, blood vessels, and inflammatory cells. Endometriosis symptoms can be accounted by these elements and the involving organs.…

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Endometrial stem cells and Endometriosis

Endometrial stem cells and Endometriosis By Dr. Youngran Park

Human endometrium is a cyclically proliferative tissue, and this monthly regeneration is likely mediated by endometrial stem (or progenitor) cells.The upper functional layer of the endometrium breaks down and is shed into the uterine cavity during menstruation. Re-epithelialization and repair…

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The endometrial stem cell markers notch-1 and numb are associated with endometriosis. 

The endometrial stem cell markers notch-1 and numb are associated with endometriosis.  By Dr. Youngran Park

The pathological mechanisms of endometriosis are still poorly understood. However, stem cells have been candidates of interest because of their high proliferation potential and their ability to differentiate into multiple lineages, contributing to characteristic traits of endometriosis. Also, previous studies…

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How good are the current guidelines on endometriosis? 

How good are the current guidelines on endometriosis?  By Dr. Youngran Park

The endometriosis was first described in 1860, yet the etiology and pathogenesis remain poorly understood. Treatment strategies vary significantly between disease severity and the symptoms of pain and/or subfertility. These challenges have resulted in multidirectional research, and the comparability of…

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Gestational diabetes risk in women with endometriosis

Gestational diabetes risk in women with endometriosis By Demet Candaş Green

Gestational diabetes (GD) is a common complication in pregnancy with several negative consequences for both mother and baby.  The risk of developing GD increases with maternal age and body mass index (BMI). Women with endometriosis conceive later than fertile women,…

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EFA Medical Conference 2017: "Cells Are the New Cure" Presentation by Dr. Max Gomez

EFA Medical Conference 2017: By Kasthuri Nair

Dr. Max Gomez is an award-winning broadcast journalist, CBS News Medical Correspondent, and a presenter at the EFA 2017 Medical Conference. Dr. Gomez’s presentation was titled “Cells Are the New Cure: The Cutting-Edge Medical Breakthroughs That Are Transforming Our Health.”…

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The role of the B lymphocytes in endometriosis: A systematic review

The role of the B lymphocytes in endometriosis: A systematic review By Murat Osman

Insight into the role of an inflammatory response in endometriosis has sparked further study into the role of different immune cells and their causal relationship to the pathogenesis of endometriosis. Several recent studies have found an association between aberrant immune…

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New Scoring System to Identify Bowel Endometriosis Syndrome

New Scoring System to Identify Bowel Endometriosis Syndrome By Özge Özkaya

Researchers in Denmark have developed a new scoring system to identify women with bowel endometriosis syndrome (BENS) and monitor the effect of treatments on the syndrome. The scoring system that can be used in everyday clinical practice is the first…

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Characteristics and location of extrapelvic endometriosis

Characteristics and location of extrapelvic endometriosis By Demet Candaş Green

The authors of this study reviewed the medical records of 1000 women with endometriosis from two geographical areas, New Haven, US and Crete, Greece over a 20-year period with a goal of identifying the presence and location of extrapelvic endometriosis…

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Human Endometrium-Derived Mesenchymal Stem Cells for Cell-based Therapies

Human Endometrium-Derived Mesenchymal Stem Cells for Cell-based Therapies By Yu Yu

Mesenchymal stem cells are a promising candidate for cell-based targeted therapies because they have characteristics such as self-renewal, multipotency, low immunogenicity, and non-oncogenicity. It has the capacity to migrate to sites of inflammation including in endometrial lesions and tumor. Most…

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Endometriosis : A Whole Body Disease

Endometriosis : A Whole Body Disease By Kasthuri Nair

Endometriosis is a disease that impacts multiple parts of an individual’s body. Seminars in Reproductive Medicine recently published a paper by Alderman III et al. entitled “The Systemic Effects of Endometriosis” explores the various comorbidities that can affect individuals suffering…

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TFF3 May Be Involved in Endometriosis Research Suggests

TFF3 May Be Involved in Endometriosis Research Suggests By Özge Özkaya

Levels of a protein called TFF3 are significantly increased in the peritoneal cavity (the abdominal space) of women with endometriosis, found a study published in the scientific journal Reproductive Sciences. This increase was in line with levels of other known…

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