Regulatory T cells influence on endometriosis development

Regulatory T cells influence on endometriosis development By Eylül GÜN

While the exact cause of endometriosis is still debated, various theories are being investigated. One approach focuses on the immune system. Regulatory T-cells (Tregs) are crucial in suppressing inflammatory immune responses and preventing autoimmune diseases, allergies, infections, and cancer. Knez…

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Stem cells may open new horizons in various gynecological disorders

Stem cells may open new horizons in various gynecological disorders By Nasuhi Engin Aydin

In-Sun Hong, PhD, a researcher in regenerative medicine at Korean Gachon University has published a comprehensive review on the role of stem cells in gynecological disorders in a recent issue of the International Journal of Biological Sciences. Endometrium changes the menstrual…

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Study Sheds Light on the Molecular Mechanism of Endometriosis Lesion Formation

Study Sheds Light on the Molecular Mechanism of Endometriosis Lesion Formation By Özge Özkaya

The production of a protein called Nucleotide-binding Oligomerization Domain 1 (NOD1) in ectopic mesenchymal stem cells may be associated with the formation of ectopic endometrial lesions, according to a new study published in the International Journal of Stem Cells. This…

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Quercetin and its effects on endometriosis

Quercetin and its effects on endometriosis By Eylül GÜN

Endometriosis, as a disease characterized by chronic inflammation and fibrosis, could be a potential target for quercetin, a flavonoid found in various foods and botanicals, and a known senolytic agent with many effects including antioxidant, anti-inflammatory, and immune-modulatory properties. Studies…

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Vicious cycle: The promoting role of previous endometriosis foci for new lesions

Vicious cycle:  The promoting role of previous endometriosis foci for new lesions By Nasuhi Engin Aydin

An experimental animal study on the pathogenesis of endometriosis from the Institute for Clinical and Experimental Surgery, Saarland University, Hamburg has been published in a recent issue of International Journal of Molecular Sciences. Endometriosis is a well-known common gynecological ailment…

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Peritoneal endometriosis and Peritoneal Immunity

Peritoneal endometriosis and Peritoneal Immunity By Selma Oransay

The peritoneum is an important immune barrier where, under normal conditions, it is balanced. External stimuli cause pro-inflammatory responses. To bring balance to this undesired situation, anti-inflammatory factors come into play. However, in patients with endometriosis, cytotoxicity of T lymphocytes,…

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Alterations of mitochondrial dynamics in endometriosis

Alterations of mitochondrial dynamics in endometriosis By Eylül GÜN

Mitochondria are known as the batteries of the cell with the ATP that they produce through oxidative phosphorylation. Mitochondrial dynamics are important mechanisms for mitochondria to maintain their integrity by continuously undergoing changes. Mitochondrial fusion is the joining of two…

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Role of peritoneal dendritic cells in endometriosis development

Role of peritoneal dendritic cells in endometriosis development By Eylül GÜN

Dendritic cells (DCs), essential antigen-presenting cells bridging innate and adaptive immunity, play a pivotal role in immune response modulation. They capture process, and present antigens, facilitating T-cell activation. DCs also promote self-tolerance by releasing tolerogenic cytokines, contributing to autoimmune disease…

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Conditioned medium from adipose tissue derived stem cells for endometriosis treatment

Conditioned medium from adipose tissue derived stem cells for endometriosis treatment By Eylül GÜN

Despite the effectiveness of both surgical and medical treatments in addressing complications related to endometriosis, there is still a high recurrence rate indicating the need for the development of novel therapeutic approaches to enhance the effectiveness of endometriosis treatment. Adipose-derived…

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Endometriosis disease modelling via induced pluripotent stem cells has been successful

Endometriosis disease modelling via induced pluripotent stem cells has been successful By Nasuhi Engin Aydin

J. Julie Kim, S. Y. Hung Research Professor and Professor of ObGyn, Reproductive Science in Medicine, Northwestern University, Chicago, Illinois, has delivered a conference at the  Annual International Medical Conference of the Endometriosis Foundation of America held in New York on April 1-2,…

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Activities of cytotoxic cells in endometriosis

Activities of cytotoxic cells in endometriosis By Eylül GÜN

Immunological dysfunction is thought to be involved in the etiopathogenesis of endometriosis, leading to defective immunosurveillance and the growth of endometriotic lesions. In this pathway, reduced cytotoxicity of peripheral and peritoneal natural killer (NK) cells is seen as a contributing…

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A call for mast cells from endometriotic lesions

A call for mast cells from endometriotic lesions By Bahar Yuksel

Endometriosis is a well-known hormonal-dependent inflammatory disease. But what type of inflammatory cells is responsible, and when does estrogen take part, are questions that have not been answered yet. In the study conducted by Alison McCallion et al, the role…

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A new potential therapeutic target in endometriosis: Galectin-3

A new potential therapeutic target in endometriosis: Galectin-3 By Eylül GÜN

The endometrial cells migrate and attach to the peritoneal surface according to the most widely accepted retrograde menstruation theory in endometriosis development. Given that only 10% of women have endometriosis, it is thought that some additional factors contribute to the…

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Immune cells in peritoneal endometriosis

Immune cells in peritoneal endometriosis By Nasuhi Engin Aydin

Dr. Burcu Ersoy and associates from The University of Sydney, Australia, published their interesting study on surgically removed peritoneal endometriosis tissues in the journal named "F&S Science". It is still a dilemma how ectopic endometrial tissues attach to the peritoneum, persist…

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Why Do Some Women Develop Endometriosis While Other Don’t?

Why Do Some Women Develop Endometriosis While Other Don’t? By Özge Özkaya

Chemotaxis by natural killer cells as well as cytotoxicity is significantly decreased in the peritoneal cavity of women with endometriosis, according to a new study published in the American Journal of Reproductive Immunology. This means that antigens that enter the…

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An important enigmatic promoter of endometriosis: immune dendritic cells

An important enigmatic promoter of endometriosis: immune dendritic cells By Nasuhi Engin Aydin

Dr. Larinha and associates from a Brasilian academic center have published their comprehensive review on the role of immune dendritic cells in the pathogenesis of endometriosis in a recent issue of the "Journal of Reproductive Immunology". Antigen-presenting dendritic cells of…

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Full understanding the role of nervous system in endometriosis could yield new gateways to novel therapeutic approaches

Full understanding the role of nervous system in endometriosis could yield new gateways to novel therapeutic approaches By Nasuhi Engin Aydin

Dr. Velho and associates from Berlin, Germany have recently published their comprehensive review on the role of the nervous system in endometriosis in a recent issue of “International Journal of Molecular Sciences”. Understanding the role of the peripheral nervous system…

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The Role of Endometrial Cytokines on the Infertility in Endometriosis Patients

The Role of Endometrial Cytokines on the Infertility in Endometriosis Patients By Eylül GÜN

The intrauterine microenvironment and underlying immunological mechanisms in endometriosis pathogenesis have been a popular research topic, mainly due to the efforts to comprehend the reason to elucidate infertility that these patients suffer from. Because of their superiority to other immune…

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Combined contraceptive pills and immune system cells in the endometriotic cyst wall

Combined contraceptive pills and immune system cells in the endometriotic cyst wall By Nasuhi Engin Aydin

Dr. Wanwisa Waiyaput and associates from Mahidol University, Bangkok, Thailand, have published their results on the immune regulatory cells of the surgically resected endometriotic cyst walls in the “Journal of Ovarian Research”. The defective immune response is believed to have…

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Myeloid-Derived Suppressor Cells are gaining importance in endometriosis

Myeloid-Derived Suppressor Cells are gaining importance in endometriosis By Nasuhi Engin Aydin

Dr. Wertel and associates from Polish academic centers published their sentimental review paper on the role of "Myeloid-Derived Suppressor Cells" in human diseases, in a recent issue of  Cells. Endometriosis, the most common gynecological disease affecting about 10% of women globally,…

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Endometrial epithelial stem/progenitor cells have links to endometriosis with potential therapeutic research aspects

Endometrial epithelial stem/progenitor cells have links to endometriosis with potential therapeutic research aspects By Nasuhi Engin Aydin

Dr. Cousins with colleagues from Australia and the USA published their review paper on a not well-known subject, the epithelial stem/progenitor cells of the endometrium. This interesting paper is recently published in the scientific journal named "Frontiers in Cell and Developmental…

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The association of chronic endometritis, endometriosis and tubal infertility

The association of chronic endometritis, endometriosis and tubal infertility By Selma Oransay

Holzer et al. from the Department of Gynecologic Endocrinology and Reproductive Medicine of  Medical University of Vienna, Austria, set up apilot prospective cohort study to evaluate the relationship between chronic endometritis, infertility and endometriosis. The results of the study were recently…

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Is hemoglobin the immune trigger of endometriosis?

Is hemoglobin the immune trigger of endometriosis? By Bahar Yuksel

The role of inflammatory cells in endometriosis has been a popular subject. However, the effects of blood inside the endometriomas were not clarified yet. The study conducted by Kusunoki et al. and published in the "Medical Molecular Morphology" journal has…

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Endometriosis and Inflammation: How to Treat it?

Endometriosis and Inflammation: How to Treat it? By Özge Özkaya

Women with endometriosis have systemic and localized inflammation within eutopic and ectopic endometrial tissues found in a study published in the "American Journal of Reproductive Immunology". More importantly, the study also found that the inflammation caused by the disease could…

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Woof Woof – Bone marrow cells are coming

Woof Woof – Bone marrow cells are coming By Yu Yu

Bone marrow contains cells that can travel to multiple organ sites and differentiate into specific tissue cells. Bone marrow-derived stem cells have also been associated with the pathogenesis of endometriosis. These cells can affect epithelial and stromal cell regeneration both…

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Endometriotic mesenchymal stem cells may promote endometriosis

Endometriotic mesenchymal stem cells may promote endometriosis By Yu Yu

The cause of endometriosis is still debatable. Many researchers have accepted that retrograde menstruation, where the endometrial fragments released during menstruation attach and colonize the ectopic locations, is the most plausible reason. However, the numbers just do not add up.…

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Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis 

Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis  By Ellen Tumimbang

Endometriosis is not only characterized by the implantation of endometriotic tissue outside of the uterine cavity but also necessitates an impaired immune response. It is suggested that abnormal immunological mechanisms causing the dysfunction of immune cells and their mediators are…

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Fallopian tubes and endometriosis

Fallopian tubes and endometriosis By Selma Oransay

There are multiple theories to explain the pathogenesis of endometriosis, among which the most popular one is Sampson's retrograde menstruation theory. The role of endometrial stem cells/progenitors are widely studied to support the origin of ectopic lesions in recent decades.…

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Immune System, Cytokines and Endometriosis

Immune System, Cytokines and Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent chronic disease. Diagnosing endometriosis is difficult because the signs and symptoms vary considerably. Therefore, the discovery of a reliable non-invasive diagnostic biomarker would represent a major advance for the clinical diagnosis of endometriosis.  It has been…

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The role of microbiota in the etiopathogenesis of endometriosis

The role of microbiota in the etiopathogenesis of endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. Although many advanced types of research about the etiology, differential diagnosis and treatment have been performed, it still remains an enigmatic disease. Dr. Bedaiwy, a scientist and physician…

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CXCR4 or CXCR7 antagonists as novel therapies for endometriosis

CXCR4 or CXCR7 antagonists as novel therapies for endometriosis By Dr. Youngran Park

Endometriosis is a common, estrogen-dependent chronic inflammatory disorder. It affects approximately 5-10% of reproductive-aged women and 20-50% of infertile women. Endometriosis also has a significant social and psychological impact on the lives of women. Despite such a significant burden, there…

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A comprehensive review on the etiopathogenesis of endometriosis

A comprehensive review on the etiopathogenesis of endometriosis By Nasuhi Engin Aydin

Endometriosis, being a heterogeneous disease has a highly complex etiopathogenesis.  A multicenter comprehensive review on this important subject from Italy, Germany, and the USA by Lagana and associates, was recently published in the "International Journal of Molecular Sciences" an open-access journal. Computerized…

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Natural killer cells receptor expression in endometriosis

Natural killer cells receptor expression in endometriosis By Yu Yu

Increasingly, studies have reported that endometriosis pathogenesis is related to defect in immune functions. The data also points to the impaired function of natural killer (NK) cells, leading to less cytotoxic NK cell activity in endometriosis. Similar to B and…

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Circulating Endometrial Cells

Circulating Endometrial Cells By Yu Yu

Endometriosis is difficult to diagnose because of non-specific symptoms. Currently, there is no biomarker that allows for non-invasive diagnosis of the condition.  Surgical laparoscopy remains the standard for diagnosis. Circulating endometrial cells (CECs) is the lymphovascular spread of endometrial cells.…

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Control on endometriosis progression by a "tyrosine kinase inhibitor"

Control on endometriosis progression by a By Irem Onur

B cells, which are important players of the immune system, are increased in the blood and peritoneal cavity of endometriosis patients. Activation of B cells and the presence of anti-endometrial autoantibodies have been also been described in women with endometriosis,…

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Importance of monocytic myeloid derived supressor cells in endometriosis

Importance of monocytic myeloid derived supressor cells in endometriosis By Nasuhi Engin Aydin

Myeloid-derived suppressor cells MDSCs are immature myeloid cells that play a major role in immunosuppression in various disease processes.  Ya Sun and associates have investigated these cells in endometriosis utilizing various laboratory methods. published their results in the "American Journal of…

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Analogous pathways of peritoneal tumor wound healing and endometriosis.

Analogous pathways of  peritoneal tumor wound healing and endometriosis. By Selma Oransay

Endometriosis, diagnosed around 10-15% of women population in their reproductive period, is a chronically progressive inflammatory disease to cause peritoneal lesions while spreading into the abdominal cavity. The pathophysiology of the adhesions between the peritoneum and pelvic organs can be…

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Could a defect in phagocytosis cause endometriosis?

Could a defect in phagocytosis cause endometriosis? By Yu Yu

The macrophages are important immune cells in the peritoneal cavity because they function to remove aberrant cells or tissues by the process of phagocytosis. In endometriosis, there is an increased number of peritoneal macrophages and heightened production of inflammation molecules…

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A new hope for a "targeted" drug for endometriosis

A new hope for a By Selma Oransay

Lin et al. from National Cheng Kung University, Taiwan, recently published in"Theranostics" the article entitled "Targeting Anthrax Toxin Receptor 2 Ameliorates Endometriosis Progression”,  report that ANTRX2 may be a novel therapeutic target for endometriosis. Thinking that the adhesion should be the first and the…

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Endometriosis and nuclear receptors

Endometriosis and nuclear receptors By Dr. Youngran Park

It is well recognized that endometriosis is a steroid-dependent disorder. In endometrial stromal cells, progesterone regulates retinoic acid production and action. Retinoids also act via a number of nuclear receptors (NRs) and are involved in normal endometrial function and endometriosis. Estrogen…

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Menstrual blood-derived stem cells

Menstrual blood-derived stem cells By Selma Oransay

Chen et al.  from the Center of Diagnosis and Treatment of İnfectious Disease, Zhejiang University, China penned this recent review in the Journal of Stem Cell Research Therapy which is presenting the clinical potential of MenSCs (Menstrual blood-derived stem cells). …

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Is the mystery for progression of endometriosis hiding out in abnormally located endometrial cells?

Is the mystery for  progression of endometriosis hiding out in abnormally located endometrial cells? By Selma Oransay

This prospective study was conducted by Hapangama et al. in Research İnstute of the University of Liverpool, UK, and the results have recently published in the Journal of Human Reproduction. The authors hypothesized that abnormally located endometrial basalis-like (SSEA1/nSOX9+)cells could be contributing to…

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IL-37 regulates ectopic endometrial stromal cells to prevent endometriosis

IL-37 regulates ectopic endometrial stromal cells to prevent endometriosis By Dr. Youngran Park

Endometriosis has been identified as a chronic inflammatory disease. It has been shown that in the plasma and peritoneal fluid, women with endometriosis exhibit aberrant numbers of immune cells and concentrations of cytokines and chemokines that promote a chronic inflammatory…

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PROPOFOL: a new combat for endometriosis?

PROPOFOL: a new combat for endometriosis? By Selma Oransay

Feng et al, from the Department of  Gynecology Weifang Medical University Hospital, Shandong, China, recently published their prospective experimental research in the journal Experimental and Therapeutic Medicine. Propofol, a rapid and short-term anesthetic substance, recently has been shown to prevent cancer through inhibiting…

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Therapeutic potential of ginseng based compound in preclinical models of endometriosis

Therapeutic potential of ginseng based compound in preclinical models of endometriosis By Yu Yu

Currently, the drug option for women with endometriosis mainly focus on reducing estrogens levels (e.g., progestins, androgens, gonadotropin-releasing hormone (GnRH) agonists, and aromatase inhibitors). However, these therapies can have low effectiveness with frequent recurrence and considerable side effects. Therefore, there…

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Oxidative Stress and Endometriosis

Oxidative Stress and Endometriosis By Murat Osman

Endometriosis is a disease characterized by ectopic endometrial tissue outside the endometrium and is associated with a background of a chronic inflammation. Recent studies have aimed to elucidate the inflammatory mediators involved in endometriotic lesions by studying immune cell interactions,…

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Endometriosis Development: Pathogenesis and genomics

Endometriosis Development: Pathogenesis and genomics By Selma Oransay

In this review recently published in the International Journal of Molecular Sciences, Baranow et al from Saint Petersburg, Russia,  hypothesize the existence of an endometriosis development genetic program (EMDP) that governs the origin of endometrium stem cells programmed for endometriosis; their transition…

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Altered Immunity in Endometriosis

Altered Immunity in Endometriosis By Yu Yu

In recent years, there has been increased attention on the role of immune system in endometriosis development. Normally, immune reactions are supposed to destroy endometrial cells seeding in the peritoneal cavity. Nonetheless, in endometriosis, these cells are able to evade,…

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Therapeutic strategies involving uterine stem cells in reproductive medicine

Therapeutic strategies involving uterine stem cells in reproductive medicine By Murat Osman

Stem cells are undifferentiated cells that often serve to regenerate tissue in states of injury or apoptosis. The endometrium has progenitor cells that replace tissue lost after each menstrual cycle. It has been postulated that excessive stem cell recruitment to…

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Role of GATA6 in Endometriosis

Role of GATA6 in Endometriosis By Özge Özkaya

Researchers discovered that a protein called GATA6 is crucial in turning endometrial stromal cells into endometriotic-like cells, which may be capable of invading surrounding tissues and growing outside the uterus.  This knowledge can be used to create cell models that…

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S100A6 May be a Promising Target for Endometriosis Treatments

S100A6 May be a Promising Target for Endometriosis Treatments By Kasthuri Nair

Peng et al., a group primarily from the Zhejiang University Medical College, recently published a paper in Gynecological Endocrinology titled “Upregulation of S100A6 in patients with endometriosis and its role in ectopic endometrial stromal cells.” This paper delineates a study…

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Mechanism for Migration of Endometriosis Cells in the Body

Mechanism for Migration of Endometriosis Cells in the Body By Kasthuri Nair

Li et al. recently published a paper in Stem Cells titled “Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis.” This article seeks to understand the mechanisms underlying the migration of endometriosis. The authors initially hypothesize that endometriosis-derived mesenchymal stem cells…

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Endometrial stem cells and Endometriosis

Endometrial stem cells and Endometriosis By Dr. Youngran Park

Human endometrium is a cyclically proliferative tissue, and this monthly regeneration is likely mediated by endometrial stem (or progenitor) cells.The upper functional layer of the endometrium breaks down and is shed into the uterine cavity during menstruation. Re-epithelialization and repair…

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The Chance of Getting Pregnant of a Woman with Endometriosis May Soon Be Predictable

The Chance of Getting Pregnant  of a Woman with Endometriosis May Soon Be Predictable By Özge Özkaya

Researchers have found a new way of predicting whether or not an embryo will be able to successfully implant into the womb of a woman with endometriosis. These findings could make it possible to predict whether she is likely to…

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Menstrual Effluent Can Change the Future of Endometriosis

Menstrual Effluent Can Change the Future of Endometriosis By Kasthuri Nair

During Endometriosis Awareness Month, Warren et al. published a paper entitled “Analysis of menstrual effluent: diagnostic potential for endometriosis” in Molecular Medicine. This paper relies heavily on the theory of retrograde menstruation, where menstrual effluent flows into the peritoneal cavity.…

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A review on the role of immune cells on the pathogenesis of endometriosis

A review on the role of immune cells on the pathogenesis of endometriosis By Murat Osman

Immune cells play a vital role in the homeostasis against infectious pathogens but also in the pathogenesis of endometriosis. Recent research has suggested that different immune cells have unique roles in this pathogenesis. Neutrophils, which are typically the primary acute…

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The endometrial stem cell markers notch-1 and numb are associated with endometriosis. 

The endometrial stem cell markers notch-1 and numb are associated with endometriosis.  By Dr. Youngran Park

The pathological mechanisms of endometriosis are still poorly understood. However, stem cells have been candidates of interest because of their high proliferation potential and their ability to differentiate into multiple lineages, contributing to characteristic traits of endometriosis. Also, previous studies…

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Potential New Target to Treat Endometriosis?

Potential New Target to Treat Endometriosis? By Özge Özkaya

Special cells called myeloid-derived suppressor cells (MDSC) could be playing a role in the development of endometriosis, suggests a study published in the European Journal of Immunology.  These cells could, therefore, be targeted by novel therapeutic agents to treat endometriosis. …

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Blood vessels formation in endometriosis

Blood vessels formation in endometriosis By Yu Yu

The endometrium undergoes dynamic changes during the menstrual cycle. Estrogen-driven angiogenesis is associated with the proliferative phase, and progesterone-driven vascular maturation occurs in the secretory phase. Hence, it is reasonable that the vascularization of endometriosis is also under complex regulation…

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Analysis of suppressive regulatory T cells and latent transforming growth factor-β-expressing macrophages in endometriosis peritoneal fluid

Analysis of suppressive regulatory T cells and latent transforming growth factor-β-expressing macrophages in endometriosis peritoneal fluid By Yu Yu

One prominent theory of endometriosis origin is the implantation of steroid hormone-sensitive endometrial cells and tissues on the peritoneal surface during retrograde menstruation and caused an inflammatory response. While women exhibit retrograde menstruation, endometriosis may be affected by women suffering…

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Autophagy in endometriosis

Autophagy in endometriosis By Dr. Youngran Park

Endometriosis is a common gynecologic disease affecting both fertile (5-10%) and infertile (20-50%) women, and it commonly causes chronic pelvic pain, dysmenorrhea, and infertility. Recent research found that the autophagy exerts a pro-apoptotic effect on normal human endometrial cells and…

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Increased Period Pain in Endometriosis Is Linked to Estrogen

Increased Period Pain in Endometriosis Is Linked to Estrogen By Özge Özkaya

Researchers in China shed light on the mechanism of how the female sex hormone estrogen may be linked to increased period pain in women with endometriosis. A better understanding of the biological mechanism leading to pelvic pain in endometriosis could…

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EFA Medical Conference 2017: "Cells Are the New Cure" Presentation by Dr. Max Gomez

EFA Medical Conference 2017: By Kasthuri Nair

Dr. Max Gomez is an award-winning broadcast journalist, CBS News Medical Correspondent, and a presenter at the EFA 2017 Medical Conference. Dr. Gomez’s presentation was titled “Cells Are the New Cure: The Cutting-Edge Medical Breakthroughs That Are Transforming Our Health.”…

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The role of the B lymphocytes in endometriosis: A systematic review

The role of the B lymphocytes in endometriosis: A systematic review By Murat Osman

Insight into the role of an inflammatory response in endometriosis has sparked further study into the role of different immune cells and their causal relationship to the pathogenesis of endometriosis. Several recent studies have found an association between aberrant immune…

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Role of immune cells in endometriosis

Role of immune cells in endometriosis By Demet Candaş Green

Immune cells have essential functions in the body such as detection and clearance of abnormal cells and debris. One of the possible mechanisms for the development of endometriosis is proposed to be the impaired function of immune system cells in…

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The Role of Natural Killer Cells in the Development of Endometriosis Unravelled

The Role of Natural Killer Cells in the Development of Endometriosis Unravelled By Özge Özkaya

Specialized immune cells called natural killer cells found in the peritoneal fluid of women with severe endometriosis may facilitate the development of the disease, according to a study published in the American Journal of Reproductive Immunology.   This finding could help…

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Human Endometrium-Derived Mesenchymal Stem Cells for Cell-based Therapies

Human Endometrium-Derived Mesenchymal Stem Cells for Cell-based Therapies By Yu Yu

Mesenchymal stem cells are a promising candidate for cell-based targeted therapies because they have characteristics such as self-renewal, multipotency, low immunogenicity, and non-oncogenicity. It has the capacity to migrate to sites of inflammation including in endometrial lesions and tumor. Most…

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The Role of IL-35 in the Pathogenesis of Endometriosis

The Role of IL-35 in the Pathogenesis of Endometriosis By Kasthuri Nair

The molecular mechanism that drives endometriosis remains elusive to this day. Zhang et al believe that interleukin 35 (IL-35) plays a role in the pathogenesis of the disease. Their recent publication in Reproductive Sciences titled “Upregulation of Interleukin 35 in…

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Endometriosis : A Whole Body Disease

Endometriosis : A Whole Body Disease By Kasthuri Nair

Endometriosis is a disease that impacts multiple parts of an individual’s body. Seminars in Reproductive Medicine recently published a paper by Alderman III et al. entitled “The Systemic Effects of Endometriosis” explores the various comorbidities that can affect individuals suffering…

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Agents Causing Red Blood Cell Lysis Worsens Endometriosis

Agents Causing Red Blood Cell Lysis Worsens Endometriosis By Kasthuri Nair

Endometriosis is a painful disease characterized by inflammation and the presence of pro-oxidation factors. These pro-oxidation factors are also released when red blood cells (RBCs) lyse. A paper titled “Dapsone hydroxylamine-mediated alterations in human red blood cells from endometriotic patients”…

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Immune Response in Endometriosis and Regulatory T cells

Immune Response in Endometriosis and Regulatory T cells By Yu Yu

The adaptive immune system is crucial for many diseases. Lymphocytes, including T cells, are particularly important in the adaptive immune system. Previous research suggested that defective immune response could play a role in endometriosis. The hypothesis proposes that the immune…

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