The duration of impairment of ovarian reserve after laparoscopic surgery

The duration of impairment of ovarian reserve after laparoscopic surgery By Murat Osman

Endometriosis is a chronic medical condition characterized by ectopic endometrial tissue that grows and invades extra-uterine tissues. It is a significant contributor to chronic pelvic pain in women of reproductive age. Endometriosis involving the ovaries and causing a cystic growth…

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Can we prevent the progression of endometriosis?

Can we prevent the progression of endometriosis? By Selma Oransay

Torres-Reveron et al. from the University of Texas, USA, planned this prospective laboratory research on female rats to assay the reduce on the progression of endometriosis and recently published the results in PloS One. At first,  endometriosis was induced in female rats…

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Endometriosis and female pelvic pain in all aspects

Endometriosis and female pelvic pain in all aspects By Hale Goksever Celik

Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence of the disease ranges between 6-10% in reproductive-aged women. However, endometriosis is more frequently encountered in women with chronic pelvic pain and…

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Does ovarian endometrioma damage the ovarian reserve?

Does ovarian endometrioma damage the ovarian reserve? By Dr. Youngran Park

Ovarian endometriomas are commonly present in 17% to 44% of women with endometriosis and are often associated with infertility and pelvic pain. There are several treatment options including surgical treatment. Cyst excision is associated with better results in terms of…

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GnRH Analogues Not Beneficial For Superovulation and Intrauterine Insemination

GnRH Analogues Not Beneficial For Superovulation and Intrauterine Insemination By Kasthuri Nair

Bansal et al, a group of authors from the All India Institute of Medical Sciences, recently published a paper titled “The Role of GnRH Analogues in Improving Outcome in Women Undergoing Superovulation and Intrauterine Insemination after Surgical Correction of Mild…

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Could the Sleep Hormone Treat Endometriosis?

Could the Sleep Hormone Treat Endometriosis? By Özge Özkaya

Melatonin blocks cell proliferation, invasion, and migration in both normal and endometriotic epithelial cells, according to a study published in the scientific journal Reproductive Biology and Endocrinology. Melatonin could, therefore, be a potential treatment for endometriosis  The formation and progression…

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Will my Endometriosis Respond to Hormone Therapy?

Will my Endometriosis Respond to Hormone Therapy? By Özge Özkaya

Every woman has a different set of hormone receptors in the lining of their uterus. Yet, hormone-based therapies that are used to treat women with endometriosis do not take into consideration these differences among patients. Analyzing, which particular hormone receptors…

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A clearer picture of "endometriosis after menopause"

A clearer picture of By Irem Onur

Delfin Avendano Tan and Marie Josephine Guanlao Almeria are obstetrician-gynecologists from the Philippines. They recently published a review article titled "Postmenopausal endometriosis: drawing a clearer picture". In this paper, the authors discussed the pathogenesis, risk factors, and management of postmenopausal…

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Emerging medical treatments for endometriosis

Emerging medical treatments for endometriosis By Murat Osman

Endometriosis is a disease whereby uterine tissue grows outside the walls of the uterus to the surfaces of other tissues in the body. It is a chronic disease and relies upon estrogen to grow and survive. Current medical therapies take…

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Could Endometriosis Be Caused by Bacteria?

Could Endometriosis Be Caused by Bacteria? By Özge Özkaya

A new concept called the bacterial contamination hypothesis in endometriosis has been proposed for the first time by researchers in Japan. This means that new potential therapies approaches could exist for this condition in addition to the conventional estrogen-suppressing therapies.…

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Treatment of Endometriosis in Adolescents

Treatment of Endometriosis in Adolescents By Özge Özkaya

Most women with endometriosis who have been treated with Lupron plus add back as adolescents felt the treatment was effective in reducing the pain caused by the condition, according to a study published in the Journal of Pediatric & Adolescent…

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Endocrine and inflammatory factors in current understanding of endometriosis

Endocrine and inflammatory factors in current understanding of endometriosis By Yu Yu

There are three forms of endometriosis: peritoneal, ovarian, and deep infiltrating. All three forms consist of endometriotic lesions containing endometrial glands, stroma, nerves, blood vessels, and inflammatory cells. Endometriosis symptoms can be accounted by these elements and the involving organs.…

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Switching to a Low-Cost Progestin May Help Reduce Endo Pain When Oral Contraceptives Won’t Work

Switching to a Low-Cost Progestin May Help Reduce Endo Pain When Oral Contraceptives Won’t Work By Özge Özkaya

The majority of women with endometriosis-associated pain were satisfied to have switched to a treatment with norethisterone acetate or NETA, a synthetic, orally active progestin, when their oral contraceptive was ineffective, found a study published in the journal Reproductive Sciences.…

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Reason Why Hormone Therapy Alone Cannot Cure Endometriosis Uncovered

Reason Why Hormone Therapy Alone Cannot Cure Endometriosis Uncovered By Özge Özkaya

Researchers in Belgium have shed light on why hormone therapy cannot cure endometriosis on its own in a study published in the scientific journal Gynecological Endocrinology.  Their findings could shape the direction of future research and may help to find…

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When Endometriosis Becomes Malignant

When Endometriosis Becomes Malignant By Kasthuri Nair

Anglesio and Yong recently wrote a review titled “Endometriosis-associated Ovarian Cancers” that was published in Clinical Obstetrics and Gynecology. This review explored the relationship between endometriosis and ovarian cancers. It is important to note that this review is a compilation of…

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What is the role of hormones on the function and development of the brain?

What is the role of hormones on the function and development of the brain? By Murat Osman

Dr. Sarah L. Berga, Professor, and Chair of Obstetrics and Gynecology Wake Forest School of Medicine aim to talk about the effects of sex hormones such as estrogens and progestins on brain health with an emphasis on the neuroprotective characteristics…

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Endometriosis Does Not Increase Overall Risk of Breast Cancer, Study Finds

Endometriosis Does Not Increase Overall Risk of Breast Cancer, Study Finds By Özge Özkaya

Endometriosis is not associated with the overall risk of breast cancer, according to a study published in the journal Obstetrics & Gynecology.  The condition may, however, be significantly associated with an increased risk of breast tumors that express estrogen receptors (ER)…

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A New Treatment Time-Table for Controlling Endometriosis-Associated Pelvic Pain

A New Treatment Time-Table for Controlling Endometriosis-Associated Pelvic Pain By Kasthuri Nair

It is no secret that Endometriosis is an extremely painful disease. Unfortunately, science has yet to determine a treatment that can effectively treat the disease or the associated pain. In their paper titled “Ethinylestradiol 20 mg/drospirenone 3 mg in a…

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Updates in the Field of Endometriosis: Epigenetics

Updates in the Field of Endometriosis: Epigenetics By Kasthuri Nair

In this chapter titled “A Review of the Epigenetic Contributions to Endometriosis,” Grimstad and Decherney examine various epigenetic influences that drive endometriosis disease progression. The epigenetic alterations they discuss include DNA methylation, histone modification, chromatin architecture changes, nuclear receptor modulation,…

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Combination Polymorphisms of Three "Estrogene-Related" Genes Increase the Risk of Endometriosis

Combination Polymorphisms of Three By Kasthuri Nair

Cardoso et al. recently published a paper titled “Combined Effect of the PGR +331C > T, CYP17A1 -34A > G and CYP19A1 1531G > A Polymorphisms on the Risk of Developing Endometriosis” in Revista brasileira de ginecologia e obstetrician. The…

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The dose of the GnRHa after laparoscopic surgery

The dose of the GnRHa after laparoscopic surgery By Yu Yu

Laparoscopic surgery is considered a routine way to diagnose and remove endometriosis. The primary concern with laparoscopic surgery is the recurrence of endometriosis because of incomplete lesion excision. Hence, the challenge is to decrease endometriosis recurrence rate. Gonadotrophin-releasing hormone agonist…

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Dienogest for Endometriosis

Dienogest for Endometriosis By Kasthuri Nair

Laganà et al. recently published an article in Expert Opinion on Drug Metabolism & Toxicology titled “Clinical dynamics of Dienogest for the treatment of endometriosis: from bench to bedside.” This article explored the benefits of using Dienogest, a progestin, to…

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Endometriosis : A Whole Body Disease

Endometriosis : A Whole Body Disease By Kasthuri Nair

Endometriosis is a disease that impacts multiple parts of an individual’s body. Seminars in Reproductive Medicine recently published a paper by Alderman III et al. entitled “The Systemic Effects of Endometriosis” explores the various comorbidities that can affect individuals suffering…

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Is it Estrogen that Regulates Endometriosis Pain?

Is it Estrogen that Regulates Endometriosis Pain? By Yu Yu

Endometriosis-associated pain is a debilitating condition; however, it is surprising that the perceived pain has no correlation to the endometriosis extent. The mechanism that causes the pain is also poorly understood. Nerve growth factor is enhanced in endometriosis and may increase…

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The Most Cost Effective Medical Treatment to Prevent Recurrent Endometriosis

The Most Cost Effective Medical Treatment to Prevent Recurrent Endometriosis By Özge Özkaya

A new study conducted in China found that a class of drugs called Gonadotropin-releasing hormone agonists (GnRH-a) is more cost effective for the treatment of recurrent endometriosis despite the fact that they are more expensive than oral contraceptives. The results…

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The Benefits of Primary Surgery

The Benefits of Primary Surgery By Kasthuri Nair

Ahmad, Hussin, and Ahmad recently conducted a cohort study, and they published the results within an article titled “An evaluation of the quality of life in women with endometriosis who underwent primary surgery: a 6-month follow-up in Sabah Women &…

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Novel Biological Pathway Could Offer new Treatment Option for Endometriosis

Novel Biological Pathway Could Offer new Treatment Option for Endometriosis By Özge Özkaya

Researchers have identified a novel biological pathway that may be involved in endometriosis. Targeting this pathway may, therefore, be a new alternative approach to treating the condition in the future.  Endometriosis is characterized by the tissue that normally lines the…

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How ERα is regulated in endometriosis?

How ERα is regulated in endometriosis? By Yu Yu

Endometriosis pathogenesis is largely influenced by estrogen. Ectopic endometrium has altered expression of ERα compared to the eutopic endometrium. It is unclear what biological processes regulate such alteration. The article by Toderow et al. in Archives of Gynecology and Obstetrics…

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Female Sex Hormone Necessary but not Enough to Cause Endometriosis

Female Sex Hormone Necessary but not Enough to Cause Endometriosis By Özge Özkaya

Estrogen, the primary female sex hormone may be necessary but is not enough to induce endometriosis, found a study published in the Journal of Bioscience.   This finding is important because it can help scientists better understand factors that cause endometriosis…

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