The Dysregulated IL-23/TH17 Axis in Endometriosis Pathophysiology
In a study published in the Journal of Immunology, Sisnett et al. explored the therapeutic potential of endometriosis with IL-23/TH17/IL-17 axis with structured into three main investigative components: human sample analysis, in vitro cell culture experiments, and an in vivo mouse model of endometriosis. The study…
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By Selma OransayImaging findings in postmenopausal endometriosis
By Selma Oransay
Most women diagnosed with endometriosis during their reproductive years become asymptomatic in postmenopausal period, but lesions remain biologically active despite lower estrogen levels. The pathophysiology of postmenopausal endometriosis remains unclear, though lesions appear less active and extensive. The risk of…
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By Nasuhi Engin AydinPostmenopausal endometriosis is often neglected
By Nasuhi Engin Aydin
Romanian academicians led by Dr. Mihai-Daniel Dinu have published their review of the published scientific data related to postmenopausal endometriosis in a recent special issue of the medical periodical Life. Even though endometriosis is accepted as a hormone-dependent disorder of…
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"Ovarian Reserve Markers" in Peritoneal Endometriosis
By Selma Oransay
Endometriosis-related subfertility is attributed to multiple factors, including mechanical obstructions, adhesions, pelvic inflammation, and diminished ovarian reserve. Serum anti-Mullerian hormone (AMH) levels and ovarian antral follicle counts (AFC) currently serve as fertility markers to diagnose decreased ovarian reserve and failure.…
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Endometrioma surgery and the ovarian reserve
By Selma Oransay
Traditionally, cystectomy is the gold standard for surgical approach owing to the reduced risk of recurrence. Still, it may lead to a reduction in postoperative ovarian volume and can be a cause of ovarian failure. The recent conservative surgical management of…
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Dienogest versus combined oral contraceptives treatment in postoperative endometriosis care
By Selma Oransay
Dienogest is a synthetic progestin derivative, like oral contraceptives, used to prevent endometriosis recurrence after surgery. Randomized clinical trials verified a significantly higher reduction in endometriotic lesions, clinical symptoms, and improved quality of life obtained when dienogest was given to…
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By Bahar Yuksel2023 MedicalConferance: Pros and cons of hormonal interventions for endometriosis - Sarah Berga, MD
By Bahar Yuksel
Prof. Berga, MD., who is the Chair of Ob&Gyn at Jacobs School Medicine and Biomed Sciences, presented this speech at the 2023 EFA Medical Conference. Dr. Berga explains that the primary goals of endometriosis treatment are to reduce pain and improve quality…
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By Özge ÖzkayaHow Good is Ultra-Long GnRH-a Treatment Before IVF for Women With Endometriosis?
By Özge Özkaya
Pretreatment with ultra-long gonadotropin-releasing hormone agonist (GnRH-a), i.e. for at least three months before in vitro fertilization (IVF), has an adverse effect on patient pregnancy outcomes with endometriosis, according to a meta-analysis of the literature published in the Journal of…
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Relation between hormone replacement therapy and postmenopausal endometriosis.
By Bahar Yuksel
The faith of endometriosis after oophorectomy with hysterectomy is unknown. It is clear that applying only a hysterectomy but leaving the affected tissue behind is not a solution for endometriosis-related symptoms. Either total clearance or leaving endometriotic tissues behind when…
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Endometriosis, Age, and Ovarian Reserve
By Özge Özkaya
The effect of endometriosis on ovarian reserve can be enhanced with older age, according to a new study published in the International Journal of Gynecology & Obstetrics. This finding is important because it can help clinicians guide their patients in…
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By Eylül GÜNAdenomyosis and the anti-mullerian hormone levels
By Eylül GÜN
The presence of endometrial glands and stroma in the myometrial layer of the uterus is called adenomyosis. It is considered a form of endometriosis and affects up to 35% of women with varying symptomatology, from asymptomatic to subfertility. For a…
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By Hale Goksever CelikPostoperative serum markers to predict serum AMH recovery following endometriosis surgery
By Hale Goksever Celik
Women with endometriosis seek treatment including ovarian cystectomy, because of symptoms that reduce their quality of life. Ovarian cystectomy using laparoscopic or robotic devices is the preferred therapy. However, it has been shown in the literature that ovarian reserve is…
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Understanding what we see: endometriosis laparoscopic appearance and microscopic verification
By Nasuhi Engin Aydin
Chia-Sui Weng and colleagues from the Mayo Clinic, USA have published their results on laparoscopic appearances and microscopy of endometriotic lesions in “The Journal of Minimally Invasive Gynecology”. Even though the diagnosis of endometriosis has evolved greatly with advanced imaging…
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The association between severe endometriosis and venous thromboembolism
By Hale Goksever Celik
For clarifying the issue of whether endometriosis patients are at risk for venous thromboembolism due to both their local immune and inflammatory responses and hormonal treatments, Wiegers et al, from the Netherlands, published an explorative cohort study entitled “Risk of…
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Endometrioma and its relation with fibrosis, dysmenorrhea, and AMH levels.
By Bahar Yuksel
Endometrioma is an indicator of endometriosis which makes it easy to diagnose the disease for most clinicians. But the symptoms and relationship of endometrioma with menstrual pain severity and the ovarian reserve as well as its markers are not well…
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A novel target proposal in endometriosis: Phoenixin
By Eylül GÜN
As well as being a hormone-dependent reproductive system disorder, endometriosis is known to be multifactorial, which makes its etiopathogenetic mechanisms even harder to understand. Many new targets have been vastly evaluated with the hope of finding a new diagnostic test…
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Which one is more effective for the preservartion of postoperative ovarian reserve?
By Selma Oransay
Although cystectomy is the most preferred treatment of endometrioma, it is still a matter of debate as it may cause a reduction in the quality and number of remaining follicles, especially important for women who are planning to conceive. Anti-Müllerian…
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It is "pain" that causes sleep disturbances and fatigue in endometriosis patients
By Bahar Yuksel
Endometriosis has been studied previously about its effects on quality of life and the possible effects on sleeping periods. The study conducted by Federica Facchin et al. questioned the reason for endometriosis to cause sleep disturbance. The authors have divided…
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Molecular alterations in endometriosis pathogenesis
By Eylül GÜN
Endometriosis has been in our lives for decades, however little is known about its pathogenesis making it hard to diagnose and manage. A review study conducted by Balasubramanian et al. from India reveals all the characteristics and the underlying conditions…
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The comparison of the effect of hemostatic techniques on ovarian reserve during endometrioma cystectomy
By Hale Goksever Celik
The possible negative effect of the surgical excision of endometriomas on the ovarian reserve has brought up the meticulous implementation of the decision for surgical approach. Dr. Raquel Silveria da Cunha Araujo et al, from Brazil, published a study titled as…
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Etiopathogenesis of Endometriosis and Links with Endometrial Cancer
By Nasuhi Engin Aydin
Professor Terzic and colleagues from the Medical School of Nazarbayev University, Kazakhstan published their review on the molecular aspects of endometriosis and endometrial cancer in “International Journal of Molecular Sciences”. The etiopathogenesis of endometriosis has remained controversial, with recent studies…
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Endometrioma post-surgical-recurrence risk factors
By Nasuhi Engin Aydin
Jiang and associates from Dailan Medical University, China published their review manuscript “Risk factors for ovarian endometrioma recurrence following surgical excision: a systematic review and meta‑analysis” in the June 2021 issue of "Archives of Gynecology and Obstetrics". The most common form of endometriosis, "ovarian…
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Women reject using hormonal drugs for endometriosis, an accelerating need for nonhormonal medications
By Bahar Yuksel
Although the pathophysiology of endometriosis is poorly understood, endocrine drugs are widely used for reducing inflammation and patients’ symptoms. Burla and colleagues aimed to evaluate the patients’ thoughts and expectations about the endocrine drugs which are used in the treatment…
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By Dr. Youngran ParkThe influence of endometrioma and surgery on ovarian reserve
By Dr. Youngran Park
Women with endometriosis and endometrioma, often have subfertility. These patients present considerable problems for the evaluation of ovarian reserve. One of the well-known ovarian reserve biomarkers is anti-Müllerian hormone (AMH) levels. So far, it was known that the reduction of…
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Antioxidant therapy for the endometriosis pain
By Selma Oransay
Ts the protective defense mechanism of cells, hence the destruction of balance between oxidants and antioxidants in our body is called "redox imbalance". The major oxidants are reactive oxygen species (ROS) that are involved in multiple cellular processes by physiologically…
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A Possible genetic target for endometriosis treatment
By Dr. Youngran Park
Mutations in the chromosome remodeling complex SWI/SNF subunit ARID1A were first identified in ovarian clear-cell carcinoma and ovarian endometrioid carcinoma, two endometriosis-associated epithelial ovarian cancer subtypes. ARID1A gene mutations are also observed in deep ovarian and deep infiltrating endometriosis, atypical endometrial…
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Endometrioma size and anti-Müllerian hormone levels
By Hale Goksever Celik
Endometriotic lesions are encountered in different locations in the pelvic cavity, including but not limited to the ovaries, the pouch of Douglas, the ureters, the bladder, and the bowel. Cystic endometriosis lesions located in the ovary are called "endometrioma". Endometriomas have…
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By Yu YuBad bad lipid go away!
By Yu Yu
Much like the progression of endometriosis, accumulating evidence suggests that systemic chronic inflammation and oxidative stress can contribute to atherosclerosis. The excess low-density lipoprotein increases inflammatory processes in the arteries, which may result in atherosclerosis. Previous studies have shown that…
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Hormone Therapy Before Endometriosis Surgery
By Yu Yu
Hormonal therapy can be effective for endometriosis, although laparoscopic surgery is required for the frequent drug-resistant symptoms. Laparoscopic surgery can markedly improve endometriosis-associated pain. The administration of GnRH agonist prior to endometriosis laparoscopic surgery may be beneficial to improve surgical…
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Estrogen Receptors and Endometriosis: What do we know now?
By Yu Yu
It has been well known that endometriosis is closely associated with steroid hormone metabolism and pathways. Estradiol promotes the growth and progression of endometriotic tissue, together with the associated inflammation and pain-related symptoms. Excess estradiol in endometriosis is mainly produced…
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By Yohan SuryoSteroid hormone receptors in endometriosis
By Yohan Suryo
Therapeutics that target the steroid hormones are the standard treatment for women with endometriosis because steroid hormones play an important role in endometrial physiology and pathogenesis of endometriosis. Examples of these therapeutics include anti-estrogens, estrogen receptor (ER) modulators, progestins, and…
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Regulation of Inflammation in Endometriosis
By Dr. Youngran Park
Endometriosis is an estrogen-dependent and multifaceted gynecological condition. Unfortunately, this disease frequently causes chronic and cyclic pelvic pain. Though there are several treatments are available, there is not an actual cure for this disease. Therefore, the development of new therapy…
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Serum anti-Müllerian hormone levels for predicting spontaneous pregnancy after endometriosis surgery
By Hale Goksever Celik
Endometriosis is a disease defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. Although there are several medical and surgical therapeutic options, the most effective treatment modality has not yet been elucidated. The main…
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By Irem OnurUrocortin: A biomarker deserving investigation for endometriosis patients
By Irem Onur
Urocortin is a neuropeptide in the corticotropin-releasing hormone family and is expressed by eutopic and ectopic human endometria. Since it has paracrine and immunomodulatory effects, urocortin is thought to contribute to the pathogenesis of endometriosis. Its expression has been thoroughly…
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Searching new biomarkers for endometriosis
By Selma Oransay
This recent article published in Advances in Clinical Chemistry, is an overall summary of characteristics, physiopathological theories, diagnostic approaches and variety of biomarkers to diagnose endometriosis and penned by Coutinho et al. from Universidade Federal de Juiz de Fora, Belo Horizonte,…
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Does Endometriosis Reduce Ovarian Reserve?
By Özge Özkaya
Markers of ovarian reserve are worse in infertile women with endometriosis compared to women who cannot conceive due to male factor infertility regardless of whether or not they have had ovarian surgery. This finding is important because it suggests that…
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By Murat OsmanThe duration of impairment of ovarian reserve after laparoscopic surgery
By Murat Osman
Endometriosis is a chronic medical condition characterized by ectopic endometrial tissue that grows and invades extra-uterine tissues. It is a significant contributor to chronic pelvic pain in women of reproductive age. Endometriosis involving the ovaries and causing a cystic growth…
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Can we prevent the progression of endometriosis?
By Selma Oransay
Torres-Reveron et al. from the University of Texas, USA, planned this prospective laboratory research on female rats to assay the reduce on the progression of endometriosis and recently published the results in PloS One. At first, endometriosis was induced in female rats…
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Endometriosis and female pelvic pain in all aspects
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal tissue outside the uterine cavity. The prevalence of the disease ranges between 6-10% in reproductive-aged women. However, endometriosis is more frequently encountered in women with chronic pelvic pain and…
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Does ovarian endometrioma damage the ovarian reserve?
By Dr. Youngran Park
Ovarian endometriomas are commonly present in 17% to 44% of women with endometriosis and are often associated with infertility and pelvic pain. There are several treatment options including surgical treatment. Cyst excision is associated with better results in terms of…
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By Kasthuri NairGnRH Analogues Not Beneficial For Superovulation and Intrauterine Insemination
By Kasthuri Nair
Bansal et al, a group of authors from the All India Institute of Medical Sciences, recently published a paper titled “The Role of GnRH Analogues in Improving Outcome in Women Undergoing Superovulation and Intrauterine Insemination after Surgical Correction of Mild…
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Could the Sleep Hormone Treat Endometriosis?
By Özge Özkaya
Melatonin blocks cell proliferation, invasion, and migration in both normal and endometriotic epithelial cells, according to a study published in the scientific journal Reproductive Biology and Endocrinology. Melatonin could, therefore, be a potential treatment for endometriosis The formation and progression…
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Will my Endometriosis Respond to Hormone Therapy?
By Özge Özkaya
Every woman has a different set of hormone receptors in the lining of their uterus. Yet, hormone-based therapies that are used to treat women with endometriosis do not take into consideration these differences among patients. Analyzing, which particular hormone receptors…
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A clearer picture of "endometriosis after menopause"
By Irem Onur
Delfin Avendano Tan and Marie Josephine Guanlao Almeria are obstetrician-gynecologists from the Philippines. They recently published a review article titled "Postmenopausal endometriosis: drawing a clearer picture". In this paper, the authors discussed the pathogenesis, risk factors, and management of postmenopausal…
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Emerging medical treatments for endometriosis
By Murat Osman
Endometriosis is a disease whereby uterine tissue grows outside the walls of the uterus to the surfaces of other tissues in the body. It is a chronic disease and relies upon estrogen to grow and survive. Current medical therapies take…
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Could Endometriosis Be Caused by Bacteria?
By Özge Özkaya
A new concept called the bacterial contamination hypothesis in endometriosis has been proposed for the first time by researchers in Japan. This means that new potential therapies approaches could exist for this condition in addition to the conventional estrogen-suppressing therapies.…
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Treatment of Endometriosis in Adolescents
By Özge Özkaya
Most women with endometriosis who have been treated with Lupron plus add back as adolescents felt the treatment was effective in reducing the pain caused by the condition, according to a study published in the Journal of Pediatric & Adolescent…
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Endocrine and inflammatory factors in current understanding of endometriosis
By Yu Yu
There are three forms of endometriosis: peritoneal, ovarian, and deep infiltrating. All three forms consist of endometriotic lesions containing endometrial glands, stroma, nerves, blood vessels, and inflammatory cells. Endometriosis symptoms can be accounted by these elements and the involving organs.…
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Switching to a Low-Cost Progestin May Help Reduce Endo Pain When Oral Contraceptives Won’t Work
By Özge Özkaya
The majority of women with endometriosis-associated pain were satisfied to have switched to a treatment with norethisterone acetate or NETA, a synthetic, orally active progestin, when their oral contraceptive was ineffective, found a study published in the journal Reproductive Sciences.…
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Reason Why Hormone Therapy Alone Cannot Cure Endometriosis Uncovered
By Özge Özkaya
Researchers in Belgium have shed light on why hormone therapy cannot cure endometriosis on its own in a study published in the scientific journal Gynecological Endocrinology. Their findings could shape the direction of future research and may help to find…
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When Endometriosis Becomes Malignant
By Kasthuri Nair
Anglesio and Yong recently wrote a review titled “Endometriosis-associated Ovarian Cancers” that was published in Clinical Obstetrics and Gynecology. This review explored the relationship between endometriosis and ovarian cancers. It is important to note that this review is a compilation of…
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What is the role of hormones on the function and development of the brain?
By Murat Osman
Dr. Sarah L. Berga, Professor, and Chair of Obstetrics and Gynecology Wake Forest School of Medicine aim to talk about the effects of sex hormones such as estrogens and progestins on brain health with an emphasis on the neuroprotective characteristics…
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Endometriosis Does Not Increase Overall Risk of Breast Cancer, Study Finds
By Özge Özkaya
Endometriosis is not associated with the overall risk of breast cancer, according to a study published in the journal Obstetrics & Gynecology. The condition may, however, be significantly associated with an increased risk of breast tumors that express estrogen receptors (ER)…
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A New Treatment Time-Table for Controlling Endometriosis-Associated Pelvic Pain
By Kasthuri Nair
It is no secret that Endometriosis is an extremely painful disease. Unfortunately, science has yet to determine a treatment that can effectively treat the disease or the associated pain. In their paper titled “Ethinylestradiol 20 mg/drospirenone 3 mg in a…
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Updates in the Field of Endometriosis: Epigenetics
By Kasthuri Nair
In this chapter titled “A Review of the Epigenetic Contributions to Endometriosis,” Grimstad and Decherney examine various epigenetic influences that drive endometriosis disease progression. The epigenetic alterations they discuss include DNA methylation, histone modification, chromatin architecture changes, nuclear receptor modulation,…
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Combination Polymorphisms of Three "Estrogene-Related" Genes Increase the Risk of Endometriosis
By Kasthuri Nair
Cardoso et al. recently published a paper titled “Combined Effect of the PGR +331C > T, CYP17A1 -34A > G and CYP19A1 1531G > A Polymorphisms on the Risk of Developing Endometriosis” in Revista brasileira de ginecologia e obstetrician. The…
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The dose of the GnRHa after laparoscopic surgery
By Yu Yu
Laparoscopic surgery is considered a routine way to diagnose and remove endometriosis. The primary concern with laparoscopic surgery is the recurrence of endometriosis because of incomplete lesion excision. Hence, the challenge is to decrease endometriosis recurrence rate. Gonadotrophin-releasing hormone agonist…
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Dienogest for Endometriosis
By Kasthuri Nair
Laganà et al. recently published an article in Expert Opinion on Drug Metabolism & Toxicology titled “Clinical dynamics of Dienogest for the treatment of endometriosis: from bench to bedside.” This article explored the benefits of using Dienogest, a progestin, to…
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Endometriosis : A Whole Body Disease
By Kasthuri Nair
Endometriosis is a disease that impacts multiple parts of an individual’s body. Seminars in Reproductive Medicine recently published a paper by Alderman III et al. entitled “The Systemic Effects of Endometriosis” explores the various comorbidities that can affect individuals suffering…
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Is it Estrogen that Regulates Endometriosis Pain?
By Yu Yu
Endometriosis-associated pain is a debilitating condition; however, it is surprising that the perceived pain has no correlation to the endometriosis extent. The mechanism that causes the pain is also poorly understood. Nerve growth factor is enhanced in endometriosis and may increase…
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The Most Cost Effective Medical Treatment to Prevent Recurrent Endometriosis
By Özge Özkaya
A new study conducted in China found that a class of drugs called Gonadotropin-releasing hormone agonists (GnRH-a) is more cost effective for the treatment of recurrent endometriosis despite the fact that they are more expensive than oral contraceptives. The results…
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The Benefits of Primary Surgery
By Kasthuri Nair
Ahmad, Hussin, and Ahmad recently conducted a cohort study, and they published the results within an article titled “An evaluation of the quality of life in women with endometriosis who underwent primary surgery: a 6-month follow-up in Sabah Women &…
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Novel Biological Pathway Could Offer new Treatment Option for Endometriosis
By Özge Özkaya
Researchers have identified a novel biological pathway that may be involved in endometriosis. Targeting this pathway may, therefore, be a new alternative approach to treating the condition in the future. Endometriosis is characterized by the tissue that normally lines the…
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How ERα is regulated in endometriosis?
By Yu Yu
Endometriosis pathogenesis is largely influenced by estrogen. Ectopic endometrium has altered expression of ERα compared to the eutopic endometrium. It is unclear what biological processes regulate such alteration. The article by Toderow et al. in Archives of Gynecology and Obstetrics…
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Female Sex Hormone Necessary but not Enough to Cause Endometriosis
By Özge Özkaya
Estrogen, the primary female sex hormone may be necessary but is not enough to induce endometriosis, found a study published in the Journal of Bioscience. This finding is important because it can help scientists better understand factors that cause endometriosis…
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