"Speckle sign": a novel transvaginal ultrasound finding for posterior compartment endometriosis

By Nasuhi Engin Aydin

Dr. Balcacer and associates from three medical institutions located in the USA report the results of their retrospective study on deep infiltrating endometriosis utilizing transvaginal ultrasound examination and the proposed  “speckle sign” in the "Journal of Ultrasound Medicine". Pelvic ultrasound…

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A pilot study for Endometriosis Potential biomarkers

A pilot study for Endometriosis Potential biomarkers By Ellen Tumimbang

Endometriosis is one of the most common female health disorders typically causing dysmenorrhea, dyspareunia, and pelvic pain, and may contribute to infertility. It is necessary to identify potential molecular biomarkers for diagnosis and regulatory factors behind the disease. The study…

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Interleukin-37b inhibits the growth of murine endometriosis-like lesions

Interleukin-37b inhibits the growth of murine endometriosis-like lesions By Nadire Duru

Endometriosis is a chronic gynecological disease that causes chronic pain and infertility in women. Despite continuous efforts and numerous research, there is, ultimately, still much to understand about the pathogenesis of endometriosis. Inflammatory factors including several interleukins have already been…

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Endometriosis signaling: the role of IL-34

Endometriosis signaling: the role of IL-34 By Yu Yu

An increasing number of studies have suggested that the pathogenesis of endometriosis is mediated by cytokines, such as interleukin (IL)−17, which promoted the formation and progression of endometriosis by up-regulating angiogenesis and pro-inflammatory cytokines secretion. IL-34 is a newly described…

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Cloverleaf Sign: A new MRI sign for diagnosing DIE

Cloverleaf Sign: A new MRI sign for diagnosing DIE By Selma Oransay

Magnetic resonance imaging provides accurate information for the staging of deeply infiltrating endometriosis, especially when the patient is virgin, obese or has limited transvaginal examinations due to pelvic pain. In this recently published study in Investive Radiology, Harma et al.…

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Study Sheds Light on Physiological Processes Associated with Endometriosis

Study Sheds Light on Physiological Processes Associated with Endometriosis By Özge Özkaya

Sensory nerves play an important role in the development of endometriosis as well as fibrosis, confirms a study by Chinese researchers.  A better understanding of physiological processes associated with the development of endometriosis can help researchers devise new ways to…

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Estrogen Receptor Signaling and Endometriosis-Associated Ovarian Cancer

Estrogen Receptor Signaling and Endometriosis-Associated Ovarian Cancer By Selma Oransay

Andersen et al. published a prospective cohort study in the Journal of Hormones and Cancer to enlighten the estrogen signaling pathway during the transition from endometriosis to endometriosis-associated ovarian cancer. Given the shared pathway of endometriosis and ovarian cancer as…

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Study Sheds Light on the Molecular Mechanism of Endometriosis Development

Study Sheds Light on the Molecular Mechanism of Endometriosis Development By Özge Özkaya

A protein called transforming growth factor-beta1 (TGF-B1) enhances the capacity of endometriotic cells or cells that make up the lining of the uterus to migrate, invade, and colonize other areas in the body. This is according to a study published…

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A Brief Review of Endometriosis

A Brief Review of Endometriosis By Timur Seckin

Endometriosis is a common disease among women of reproductive age. It is more frequently seen among women without prior pregnancies, women with a family history of endometriosis, and women with abnormal menstrual periods. Peiris et al., researchers from the United…

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Could the Sleep Hormone Treat Endometriosis?

Could the Sleep Hormone Treat Endometriosis? By Özge Özkaya

Melatonin blocks cell proliferation, invasion, and migration in both normal and endometriotic epithelial cells, according to a study published in the scientific journal Reproductive Biology and Endocrinology. Melatonin could, therefore, be a potential treatment for endometriosis  The formation and progression…

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The pathogenesis of endometriosis : New discoveries with clinical impact

 The pathogenesis of endometriosis : New discoveries with clinical impact By Nasuhi Engin Aydin

In this recent review article that appeared in Current Women’s Health Reviews, compiled by researchers from the Department of Molecular Cell Biology and Human Genetics, Institute of Cell Biology and Neuroscience Frankfurt, Germany the following important points in regard to the molecular and cellular pathogenesis of…

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"N-myc Downstream-Regulated Gene 1" and Endometriosis.

By Dr. Youngran Park

NDRG1 is implicated in many different cellular functions such as differentiation, proliferation, migration, invasion, and vascularization. In endometriosis, NDRG1 is identified as an inhibitor of several important pathways. To focus on the potential function of NDRG1 in endometriosis, Lou et…

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Updates in the Field of Endometriosis

Updates in the Field of Endometriosis By Kasthuri Nair

A lot of progress has been made thus far in the field of endometriosis. Research has discovered various genetic and epigenetic components involved in endometriosis. There has also been a progression in the diagnosis and treatment of the disease since…

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Endometriosis : A Whole Body Disease

Endometriosis : A Whole Body Disease By Kasthuri Nair

Endometriosis is a disease that impacts multiple parts of an individual’s body. Seminars in Reproductive Medicine recently published a paper by Alderman III et al. entitled “The Systemic Effects of Endometriosis” explores the various comorbidities that can affect individuals suffering…

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Retinoic Acid Signaling Involved in Endometrial Decidualization

Retinoic Acid Signaling Involved in Endometrial Decidualization By Murat Osman

Decidualization occurs in the eutopic endometrium during the luteal phase and is controlled by signaling pathways such as cyclic adenosine monophosphate (cAMP) and progesterone. Researchers from the Northwestern University School of Medicine reported in their recent paper entitled "Altered Retinoid…

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