​Modeling the feto-maternal interface using pluripotent stem cells

​Modeling the feto-maternal interface using pluripotent stem cells By Özge Özkaya

Researchers from Columbia University led by Dr. Mijo Simunovic created a model using which they can study the relationship between the developing human embryo and the endometrium. The findings were presented at the Annual International Medical Conference of the Endometriosis Foundation…

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A new potential therapeutic target in endometriosis: Galectin-3

A new potential therapeutic target in endometriosis: Galectin-3 By Eylül GÜN

The endometrial cells migrate and attach to the peritoneal surface according to the most widely accepted retrograde menstruation theory in endometriosis development. Given that only 10% of women have endometriosis, it is thought that some additional factors contribute to the…

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A plea from pathologists: standardized protocols for adenomyosis and endometriosis  

A plea from pathologists: standardized protocols for adenomyosis and endometriosis   By Nasuhi Engin Aydin

Pathologist Drs. Camboni and Marbaix from Brussels, Belgium published their comprehensive review on adenomyosis and endometriosis titled “Ectopic endometrium: the pathologists’ perspective” in a recent issue of the International Journal of Molecular Sciences. Endometriosis and adenomyosis are well-known entities as…

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Etiopathogenesis of Endometriosis and Links with Endometrial Cancer

Etiopathogenesis of Endometriosis and Links with Endometrial Cancer By Nasuhi Engin Aydin

Professor Terzic and colleagues from the Medical School of Nazarbayev University, Kazakhstan published their review on the molecular aspects of endometriosis and endometrial cancer in “International Journal of Molecular Sciences”. The etiopathogenesis of endometriosis has remained controversial, with recent studies…

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Not all endometriotic lesions behave similar to the eutopic endometrium

Not all endometriotic lesions behave similar to the eutopic endometrium By Eylül GÜN

The most widely accepted theory of endometriosis pathophysiology is Sampson’s theory of retrograde menstruation which suggests the ectopic lesions undergo the same hormonal and morphological changes as eutopic endometrium during the menstrual cycle. Recent studies have shown that only a…

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Non-invasive Construction of Endometrial Organoids

Non-invasive Construction of Endometrial Organoids By Eylül GÜN

Organoids are 3D culture structures established in vitro and they reflect the aspects of the tissue or the organ they represent. They are seen as important tools in the evaluation of normal development, disease course, and the prediction of the…

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Endometrial epithelial stem/progenitor cells have links to endometriosis with potential therapeutic research aspects

Endometrial epithelial stem/progenitor cells have links to endometriosis with potential therapeutic research aspects By Nasuhi Engin Aydin

Dr. Cousins with colleagues from Australia and the USA published their review paper on a not well-known subject, the epithelial stem/progenitor cells of the endometrium. This interesting paper is recently published in the scientific journal named "Frontiers in Cell and Developmental…

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Autophagy, Endometrium and Endometriosis

Autophagy, Endometrium and Endometriosis By Dr. Youngran Park

Autophagy, or autophagocytosis, is a self-digestion process by which cells recycle non-functional proteins to repurpose them. Unwanted cellular parts in cytosolic material are first isolated within double-membrane vesicles called the autophagosome, which subsequently fuses with the acidic lysosome. Autophagy is a survival…

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DNA damage response in eutopic endometria of endometriosis patients

DNA damage response in eutopic endometria of endometriosis patients By Dr. Youngran Park

The DNA damage response (DDR) is a network of cellular pathways that sense, signal, and repair the lesions occurring in DNA. Surveillance proteins that monitor DNA integrity activate the DNA repair pathways in response to DNA damage and try to prevent the generation of potentially deleterious mutations. Endometriosis is an estrogen-dependent…

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It is time for non-invasive tests for peritoneal endometriosis diagnosis

It is time for non-invasive tests for peritoneal endometriosis diagnosis By Nasuhi Engin Aydin

Maria Szubert with colleagues from Lodz Medical University, Poland, investigated the possibility of potential diagnostic biomarkers in the eutopic endometrial tissue from peritoneal endometriosis patients and published their results in the "Journal of Gynecology Obstetrics and Human Reproduction". Currently, diagnostic…

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Cancer-associated mutations and endometriosis

Cancer-associated mutations and endometriosis By Ellen Tumimbang

Endometriosis is thought to benign gynecological disease. However, recent studies compiled in this review paper suggest that spontaneous somatic mutations are driven to occur during the cyclic bleeding resulting in endometriosis tissue undergoing repeated tissue injury and repair. Mutations are…

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tRNA-derived fragments in ovarian endometriosis?

tRNA-derived fragments in ovarian endometriosis? By Dr. Youngran Park

Endometriosis is an estrogen-dependent mysterious disorder characterized by the presence of endometrium outside the normal location of the uterus cavity. This disease affects approximately 10% of reproductive-aged women and becomes a major reason for infertility in reproductive-aged women and dysmenorrhea…

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The genetic mutations in uterine adenomyosis

The genetic mutations in uterine adenomyosis By Hale Goksever Celik

Adenomyosis is defined as the localization of endometrial stromal and glandular cells in the myometrium. This disease is a reproductive-aged women disease, like endometriosis. Additionally, adenomyosis is frequently observed together with endometriosis and leiomyomas due to common histological features and…

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The role of microbiota in the etiopathogenesis of endometriosis

The role of microbiota in the etiopathogenesis of endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. Although many advanced types of research about the etiology, differential diagnosis and treatment have been performed, it still remains an enigmatic disease. Dr. Bedaiwy, a scientist and physician…

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Endometrial single cells to contribute preexisting endometriosis.

Endometrial single cells to contribute preexisting endometriosis. By Dr. Youngran Park

Endometriosis is an estrogen-dependent inflammatory disease. This disease affects approximately 10% of reproductive-aged women and 20% to 50% of infertile women. Multiple hypotheses have been proposed for the origin of endometriosis. Retrograde menstruation is believed to take part by the…

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A link between endometrioid ovarian carcinoma and endometriosis.

A link between endometrioid ovarian carcinoma and endometriosis. By Selma Oransay

Ciavattini et al.from Polytechnic University Ancona, Italy create a pilot study which recently published in Oncology Letters to clarify the link between endometriosis and endometrioid ovarian cancer. The unfolded protein response (UPR) activity as a promoter of neoplastic progression of malignancies is…

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Is the mystery for progression of endometriosis hiding out in abnormally located endometrial cells?

Is the mystery for  progression of endometriosis hiding out in abnormally located endometrial cells? By Selma Oransay

This prospective study was conducted by Hapangama et al. in Research İnstute of the University of Liverpool, UK, and the results have recently published in the Journal of Human Reproduction. The authors hypothesized that abnormally located endometrial basalis-like (SSEA1/nSOX9+)cells could be contributing to…

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Does the presence of endometriosis increase the risk of gynecologic malignancies?

Does the presence of endometriosis increase the risk of gynecologic malignancies? By Serdar Balci

Endometriosis shares common risk factors with endometrial carcinoma and ovarian carcinomas such as obesity, type 2 diabetes, hyperestrogenism, and reproductive characteristics. Endometriosis is also known to be a risk factor for gynecologic malignant tumors. In this study, Li et.al. have…

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What clinicians know about adenomyosis? Any association with severe endometriosis?

What clinicians know about adenomyosis? Any association with severe endometriosis? By Selma Oransay

Dior et al. from the Royal Women's Hospital in Parkville, Australia, designed a prospective study to assess the association between severity of endometriosis and sonographic evidence of adenomyosis (SEOA) in their recently published article appearing in The Journal of Minimally…

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Fighting with endometriosis

Fighting with endometriosis By Irem Onur

Maduro M.R. reviewed three separate studies on potential new targets to successfully manage endometriosis in her recent paper titled “Novel Strategies to Fight Endometriosis” published in the journal Reproductive Sciences. In the autotransplantation rat model of Torres-Reveron et al., the…

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Catching Endometriosis Early

Catching Endometriosis Early By Kasthuri Nair

Li et al., a group primarily from Sun Yat-sen University in the People’s Republic of China, recently published an article titled “Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages” in Reproductive Biology and Endocrinology. The…

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Non-coding RNAs in endometriosis

Non-coding RNAs in endometriosis By Dr. Youngran Park

The pathophysiological mechanisms causing the development of endometriosis, which is a heterogeneous disease remain enigmatic, and a lack of effective biomarkers necessitates surgical intervention for diagnosis. Non-coding RNA (ncRNA) molecules, which are important regulators of cellular function, have been implicated…

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Endometriosis From an Epigenetic Lens

Endometriosis From an Epigenetic Lens By Kasthuri Nair

Samadieh et al. from the Royan Institute for Reproductive Biomedicine, recently published an article in Reproductive Sciences titled “Epigenetic Dynamics of HOXA10 Gene in Infertile Women With Endometriosis.” In this paper, the researchers wanted to observe HOXA10 gene expression in…

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Endometrial stem cells and Endometriosis

Endometrial stem cells and Endometriosis By Dr. Youngran Park

Human endometrium is a cyclically proliferative tissue, and this monthly regeneration is likely mediated by endometrial stem (or progenitor) cells.The upper functional layer of the endometrium breaks down and is shed into the uterine cavity during menstruation. Re-epithelialization and repair…

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Enhanced UGT1A1 Gene and Protein Expression in Endometriotic Lesions.

Enhanced UGT1A1 Gene and Protein Expression in Endometriotic Lesions. By Dr. Youngran Park

The estrogen plays an essential role in endometriosis. Lately, it is becoming evident that, besides the circulating levels of estrogens, the balance of synthesis versus inactivation (metabolism) of estrogens by intralesional steroid-metabolizing enzymes also determines the local net estrogen availability.…

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The endometrial stem cell markers notch-1 and numb are associated with endometriosis. 

The endometrial stem cell markers notch-1 and numb are associated with endometriosis.  By Dr. Youngran Park

The pathological mechanisms of endometriosis are still poorly understood. However, stem cells have been candidates of interest because of their high proliferation potential and their ability to differentiate into multiple lineages, contributing to characteristic traits of endometriosis. Also, previous studies…

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Inhibition of Histone methyltransferase for fighting endometriosis

Inhibition of Histone methyltransferase for fighting endometriosis By Dr. Youngran Park

Although the histone methyltransferase EZH2 and its product H3K27me3 are well studied in cancer, little is known about their role and potential as therapeutic targets in endometriosis. It has been previously reported that the endometriotic lesions are characterized by global…

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Progesterone resistance can cause endometriosis

Progesterone resistance can cause endometriosis By Demet Candaş Green

Progesterone is a steroid hormone produced by the corpus luteum of ovaries. Abnormal progesterone signaling (i.e., progesterone resistance) in the endometrium has been implicated in the establishment of eutopic and ectopic endometrial implants. Several causes for faulty progesterone signaling have been…

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Biomarkers as a Diagnostic Tool

Biomarkers as a Diagnostic Tool By Kasthuri Nair

Ahn, Singh and Tayade discuss the difficulties and delay in diagnosing Endometriosis in their paper titled “Biomarkers in endometriosis: challenges and opportunities.” Thus far research has identified a multitude of potential biomarkers that are found in various parts of the…

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DNA methylation changes in endometrium during the transition from pre-receptive to receptive phase

DNA methylation changes in endometrium during the transition from pre-receptive to receptive phase By Yu Yu

The endometrium is unique in that it undergoes remarkable changes during menstrual cycle under the control of hormones, estrogen, and progesterone. The function of the endometrium is crucial for embryo implantation, during which the endometrium is receptive around a week…

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Glycodelin and altered endometrial function in endometriosis

Glycodelin and altered endometrial function in endometriosis By Yu Yu

A laparoscopic examination is the only diagnostic tool for endometriosis to date. Since the procedure is invasive, there has been much effort by researchers to develop a biomarker for non-invasive diagnosis of endometriosis. To this end, there has been growing…

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Hormonal Contraceptives and Endometriomas

Hormonal Contraceptives and Endometriomas By Kasthuri Nair

Hormonal contraceptive has recently become a popular choice of birth control for many women. The European Journal of Obstetrics & Gynecology and Reproductive Biology recently published an article entitled “Incidence of ovarian endometrioma among women with peritoneal endometriosis with and…

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The Endometrium Itself is Genetically Different in Endometriosis Patients

The Endometrium Itself is Genetically Different in Endometriosis Patients By Özge Özkaya

Researchers in China identified a number of genes that are differentially expressed in the eutopic endometrium of women with endometriosis and those without. The researchers think that these genes may be involved in the development of endometriosis and that they…

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Scientists Grow Miniature Model of Human Endometrium in the Laboratory

Scientists Grow Miniature Model of Human Endometrium in the Laboratory By Özge Özkaya

Researchers in the U.K. managed to grow a miniature functional model of the human endometrium in the laboratory for the first time. These so-called organoids could help scientists better understands events associated with conditions such as endometriosis and help them…

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