The location of adenomyosis, and recurrent abortion

The location of adenomyosis, and recurrent abortion By Selma Oransay

ESHRE defines repeated pregnancy loss (RPL) as the loss of pregnancies with two or more weeks of gestation. Adenomyosis is the presence of ectopic endometrium, in the myometrium. High-resolution transvaginal ultrasound and sonographic criteria can help to diagnose the disease…

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Endometriosis vs. adenomyosis : is there a common pathogenesis ?

Endometriosis vs. adenomyosis : is there a common pathogenesis ? By Nasuhi Engin Aydin

This is a collaborative review on the pathophysiology of adenomyosis and endometriosis by academicians of the University of Leicester, UK; Fudan University, Shanghai, China and Sapienza University of Rome, Italy, published in a recent issue of “Biomolecules”. The pathophysiology of…

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Pregnancy outcomes of women with endometriosis/adenomyosis.

Pregnancy outcomes of women with endometriosis/adenomyosis. By Selma Oransay

Endometriosis and adenomyosis are diseases presented by ectopic growth of endometrial-gland-like tissues, which we can find in ovaries, pelvic organs, and myometrium. These diseases are causes of hypermenorrhea, dysmenorrhea, chronic pelvic pain, and infertility. Although the number of reports about…

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Blood-based biomarkers for the detection of endometriosis and adenomyosis

Blood-based biomarkers for the detection of endometriosis and adenomyosis By Eylül GÜN

One of the biggest challenges in endometriosis management is the delay in diagnosis. Scientists have been trying to come up with biomarkers to detect it quicker. Thinking blood-based biomarkers could aid in earlier diagnosis and help with the duly administration…

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Underestimation of Dysmenorrhea in adolescents

Underestimation of Dysmenorrhea in adolescents By Hale Goksever Celik

Women with endometriosis may suffer from painful symptoms, especially during menstruation or sexual intercourse. One of the main etiologic reasons for secondary dysmenorrhea is endometriosis, and it has a poor impact on life quality. Underestimation of dysmenorrhea and consideration of…

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Pain Scoring System for Deep Endometriosis

 Pain Scoring System for Deep Endometriosis By Selma Oransay

The numeric pain scale is commonly used to interpret pain score values. According to the National Comprehensive Cancer Network guidelines, pain scores of 4-7 points indicate moderate, and  8-10 points indicate severe pain. Patients with a local pain score of…

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Outcomes of chronic pelvic pain after niche repair

Outcomes of chronic pelvic pain after niche repair By Selma Oransay

Rapidly increasing cesarian section rates in recent years increased the cesarian scar defects and the development of "isthmoceles". Isthmocele is a myometrial lesion located around the isthmic portion of the uterus that is a myometrial discontinuity or hypoechoic triangle in…

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Deep Infiltrating Endometriosis and Adenomyosis have different genetic pathways

 Deep Infiltrating Endometriosis and Adenomyosis have different genetic pathways By Bahar Yuksel

It is still not defined whether adenomyosis is also a deep endometriosis component or not. In the study conducted by Marshall et al, the researchers compared the gene expression patterns between deep infiltrating endometriosis (DIE) and adenomyosis uteri in order…

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Adenomyosis and infertility: Does immunology mapping help?

Adenomyosis and infertility: Does immunology mapping help? By Nasuhi Engin Aydin

Professor Dr. Wolfgang Küpker (MD, PhD), Medical Director and CEO of IVF Baden Baden at the University of Schleswig Holstein in Lübeck delivered a conference at the  Annual International Medical Conference of the Endometriosis Foundation of America held in New York on April…

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The #Enzian classification, an essential tool for surgical management of severe endometriosis

The #Enzian classification, an essential tool for surgical management of severe endometriosis By Hale Goksever Celik

The lecture entitled "The #Enzian classification, an essential tool for surgical management of severe endometriosis" was presented by Professor. Jörg Keckstein, from the University Ulm, Germany, at the Annual International Medical Conference of the Endometriosis Foundation of America held in New York on…

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Epigenetic defects of stromal cells in endometriosis and adenomyosis lead to estrogen sensitivity

Epigenetic defects of stromal cells in endometriosis and adenomyosis lead to estrogen sensitivity By Nasuhi Engin Aydin

Serdar Bulun, MD, J.J. Sciarra Professor and Chair Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois has delivered a conference on “Endometriosis and adenomyosis: single-cell genome-wide approaches” at the Annual International Medical Conference of the Endometriosis Foundation…

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Is there any advantage of addition of hysterectomy on deep endometriotic pelvic pain or on the quality of life?

Is there any advantage of addition of hysterectomy on deep endometriotic pelvic pain or on the quality of life?  By Selma Oransay

 The addition of hysterectomy and salpingo-oophorectomy to the endometriosis excision surgery provided greater benefits when compared to excision surgery alone, according to the results of a comparison study that was recently published in the journal named "Facts Views and Visions in Obstetrics…

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The enhanced invasiveness, migration and the development of adenomyosis: Importance of M2 macrophages

The enhanced invasiveness, migration and the development of adenomyosis: Importance of M2 macrophages By Hale Goksever Celik

Adenomyosis is the ectopic presence of endometrial stromal and glandular cells inside the myometrial tissue. Adenomyosis is diagnosed in women with gynecological problems with an incidence of 20%, although it is encountered much more frequently in hysterectomy specimens. Among many…

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How Common is Adenomyosis Among Subfertile Women?

How Common is Adenomyosis Among Subfertile Women? By Özge Özkaya

Around 10% of women who have reduced fertility have isolated adenomyosis, according to a new study published in the scientific journal Ultrasound in Obstetrics & Gynecology. The prevalence of the disease seems to vary according to the presence of endometriosis…

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The most common gynecologic admissions to the emergency: Endometriosis and adenomyosis

The most common gynecologic admissions to the emergency: Endometriosis and adenomyosis By Hale Goksever Celik

Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Adenomyosis occurs when the endometrial glandular and stromal tissue grows into the muscular wall of the uterus, called the myometrium. Women having adenomyosis also…

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Ultrasonographic Presurgical Staging and Classification of Endometriosis

 Ultrasonographic Presurgical Staging and Classification of Endometriosis By Selma Oransay

Laparoscopic surgery is the gold standard for diagnosing endometriosis, but a preoperative imaging procedure is strongly recommended. Transvaginal sonography by a skilled examiner is not inferior to MRI diagnostics regarding sensitivity and specificity in predicting the extension of deep endometriosis.  …

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Adenomyosis and the anti-mullerian hormone levels

Adenomyosis and  the anti-mullerian hormone levels By Eylül GÜN

The presence of endometrial glands and stroma in the myometrial layer of the uterus is called adenomyosis. It is considered a form of endometriosis and affects up to 35% of women with varying symptomatology, from asymptomatic to subfertility. For a…

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Who Is Diagnosing my Endo?

Who Is Diagnosing my Endo? By Özge Özkaya

It is possible to acquire the skills necessary to diagnose endometriosis lesions as well as adenomyosis using three-dimensional rectosonography after a short learning period in an expert radiology center. This is according to a new study by French researchers published…

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Adenomyosis Increases Risk of Surgical Complications

Adenomyosis Increases Risk of Surgical Complications By Özge Özkaya

Adenomyosis increases the risk of deep endometriosis surgery complications, according to a new study published in the journal Scientific Reports. Patients with deep endometriosis and adenomyosis should therefore be informed about this risk before undergoing surgery. Adenomyosis occurs together with…

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Preferential expression of some membrane type matrix metalloproteinase proteins

Preferential expression of some membrane type matrix metalloproteinase proteins By Nasuhi Engin Aydin

Dr. Maoga and associates from academic institutions located in Germany and Kenya have published their findings on the immunohistochemical expression of MT-MMP proteins, namely MT2-MMP (MMP15) and MT3-MMP (MMP16) in the eutopic endometrium of healthy and endometriotic patients; and also…

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Prevalence of endometriosis and adenomyosis by transvaginal ultrasound.

Prevalence of endometriosis and adenomyosis by transvaginal ultrasound. By Selma Oransay

Women who present dyspareunia, dysmenorrhea, dysuria, dyschezia, chronic abdominal, and pelvic pain, and infertility would benefit from the early investigation. If the correct diagnosis of endometriosis and/or adenomyosis can be made in advance, early treatment will improve the quality of…

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Algorithm for pain management in endometriosis

Algorithm for pain management in endometriosis By Selma Oransay

One of the debilitating symptoms of endometriosis is pain. Mostly due to delayed diagnosis and the high recurrence rate, even after the surgical and hormonal therapy pain control may not be sufficient causing the patient to suffer for decades.  Endometriosis-associated…

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A novel approach to a common lesion: mapping adenomyosis by imaging modalities

A novel approach to a common lesion: mapping adenomyosis by imaging modalities By Nasuhi Engin Aydin

Dr. Habiba from Leicester, UK, and Dr. Benagiano from Rome, Italy, have published their overview on adenomyosis in an attempt to set light on a clinically important topic in a recent issue of the "International Journal of Environmental Research and…

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Cancer invasion genes to explain invasiveness of adenomyosis

Cancer invasion genes to explain invasiveness of adenomyosis By Bahar Yuksel

Adenomyosis looks similar to endometriosis, but it is not the same. However, the invasiveness and migration patterns of both diseases have something in common. The study conducted by Guo et al. questioned whether invasiveness genes that have already been studied…

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Intravascular adenomyomatosis: an important entity to be alert

Intravascular adenomyomatosis: an important entity to be alert By Nasuhi Engin Aydin

Pathologists from Stanford University, USA have recently published four novel cases of intravascular adenomyomatosis co-existing with pelvic endometriosis in a recent issue of “Human Pathology”. Intravascular leiomyomatosis is characterized by the presence of smooth muscle in venous and lymphatic spaces…

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A plea from pathologists: standardized protocols for adenomyosis and endometriosis  

A plea from pathologists: standardized protocols for adenomyosis and endometriosis   By Nasuhi Engin Aydin

Pathologist Drs. Camboni and Marbaix from Brussels, Belgium published their comprehensive review on adenomyosis and endometriosis titled “Ectopic endometrium: the pathologists’ perspective” in a recent issue of the International Journal of Molecular Sciences. Endometriosis and adenomyosis are well-known entities as…

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How does adenomyosis affect IVF outcomes?

How does adenomyosis affect IVF outcomes? By Hale Goksever Celik

Adenomyosis is defined as the localization of endometrial tissue in the muscle layer of uterus. Several theories have been proposed to explain the reasons of adenomyosis-associated infertility including uterine dysperistalsis, abnormal transportation of sperm in the uterine cavity, and embryo…

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Endometriosis Increases the Risk of Premature Labor Study Reports

Endometriosis Increases the Risk of Premature Labor Study Reports By Özge Özkaya

Women with endometriosis who conceive naturally are at a high risk of giving birth prematurely and having their baby admitted to neonatal intensive care unit, compared to women without the disease, according to the results of a clinical study. The…

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Ovarian cancer risk in endometriosis and adenomyosis

Ovarian cancer risk in endometriosis and adenomyosis By Eylül GÜN

Through the historical development of the nomenclature for endometriotic tissue found inside and/or outside the uterus, many terminologies have been used. The accepted terminology is still the one introduced by Sampson: “Endometriosis”. “Adenomyosis” also known as “endometriosis interna” which is…

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Uterine cancer risk in "endometriosis" and "adenomyosis"

Uterine cancer risk in By Selma Oransay

Adenomyosis and endometriosis share similar characteristics, and endometriosis is reported to have an increased risk of ovarian cancer. However, the risk of uterine cancer is not clear yet. Hermens and colleagues from Catharina Hospital, from the Netherlands, designed a population-based…

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Adenomyosis in adolescents

Adenomyosis in adolescents By Nasuhi Engin Aydin

Dr. Exacoustos and colleagues from two tertiary referral university hospitals in Italy published their results on adenomyosis in adolescent patients in a recent issue of  “The Journal of Minimally Invasive Gynecology”. Adenomyosis is the presence of endometrial glands and stroma…

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The clues for pain and infertility in endometriosis/adenomyosis complex

The clues for pain and infertility in endometriosis/adenomyosis complex By Nasuhi Engin Aydin

Drs. Gruber and Mechsner from Charite University-Berlin, Germany published their comprehensive review on pathophysiological background of endometriosis and adenomyosis in the scientific periodical “Cells”. Chronic pain and fertility problems are the main clinical issue in endometriosis and adenomyosis patients. In order to…

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Is the presence of nerve fibers in the endometrium associated with endometriosis?

Is the presence of nerve fibers in the endometrium associated with endometriosis? By Eylül GÜN

Endometriosis is a common disease in reproductive women and diagnostic imaging have a limited role in its diagnosis. The gold standard diagnostic method remains to be the histopathological examination of the tissue obtained via laparoscopy. One of its most common…

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Adenomyosis, fertility, and obstetric outcomes

Adenomyosis, fertility, and obstetric outcomes By Hale Goksever Celik

Adenomyosis is the localization of endometrial glandular and stromal cells within the myometrial wall. Although magnetic resonance imaging has a higher ability to discriminate and identify adenomyosis, transvaginal ultrasonography is a cheaper, more accessible, and practical method in daily clinical practice for…

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Impact of adenomyosis on sexual life

Impact of adenomyosis on sexual life By Selma Oransay

Considering the similar etiopathogenesis and pain symptoms between adenomyosis and deep infiltrating endometriosis, Alcalde et al. from the Department of Gynecology, University of Barcelona, Spain, aimed to call attention to the presence of potential sexual dysfunction not only in patients with deep…

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Predictors for achieving pregnancy in patients with adenomyosis and endometriosis

Predictors for achieving pregnancy in patients with adenomyosis and endometriosis By Bahar Yuksel

Adenomyosis and endometriosis are benign conditions, however, both situations are associated with deterioration of life quality, a requirement of hospital administrations, and infertility. Laparoscopic surgery is the main treatment option especially for women who desire pregnancy. Shi and colleagues aimed…

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Ultrasonographic signs of adenomyosis, surgery and infertility in endometriosis patients

Ultrasonographic signs of adenomyosis, surgery and infertility in endometriosis patients By Bahar Yuksel

Adenomyosis is simply defined as the presence of endometrial glands and stroma within the uterine myometrium and is related to severe menstrual bleeding, pain, and infertility. Previous reports demonstrated the coexisting of endometriosis and adenomyosis is common. In the present…

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The need for the standardization of diagnostic protocols for "adenomyosis"

The need for the standardization of diagnostic protocols for By Nasuhi Engin Aydin

Dr. Squillace and associates from Brasilian Academic and Health Centers published their paper titled “Adenomyosis and in vitro fertilization impacts- a literature review” in a recent issue of "JBRA Assisted Reproduction". As common gynecological ailment adenomyosis frequently coexists with endometriosis.…

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Evaluation of preoperative risk factors of ureteral endometriosis

Evaluation of preoperative risk factors of ureteral endometriosis By Selma Oransay

Endometriosis affects the urinary tract in 1% to 5.5% of the patients, and among them, bladder involvement is 70-85%, while ureteral involvement alone is 9% to 23%.  Ureteral endometriosis is most commonly unilateral, especially on the left side, usually affecting…

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Adenomyosis: accuracy of the diagnostic methods and the synchronism with deep infiltrating endometriosis

Adenomyosis: accuracy of the diagnostic methods and the synchronism with deep infiltrating endometriosis By Nasuhi Engin Aydin

Dr. Alborzi and associates from Shiraz University of Medical Sciences, Iran, have published their comprehensive retrospective research conducted on 3725 patients with clinical symptoms of endometriosis over a period of 3 years, in "Reproductive Sciences" medical journal.  A relationship between…

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Current research on adenomyosis tissues with immunohistochemistry reveal novel findings

Current research on adenomyosis tissues with immunohistochemistry reveal novel findings By Nasuhi Engin Aydin

Dr. Xiaofang Xu and associates from Fudan University, China have recently published their research on adenomyosis-related research results in "Reproductive Biology and Endocrinology". Adenomyosis is a benign gynecological condition, prevalent worldwide that is characterized by the presence of ectopic endometrial tissues in…

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The cause of PAIN in patients with adenomyosis

The cause of PAIN in patients with adenomyosis By Bahar Yuksel

Adenomyosis is known to be a painful disease with heavy menstrual cycles and negatively affects fertility. Even adenomyosis and endometriosis look alike, it is still crucial to call them as different variation of the same disease. The mechanism underlying the…

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Separation of epithelia and stroma components in endometriosis lesions yields remarkable molecular points - Ie-Ming Shih, MD, Ph.D.

Separation of epithelia and stroma components in endometriosis lesions yields remarkable molecular points - Ie-Ming Shih, MD, Ph.D. By Nasuhi Engin Aydin

The pathologies of adenomyosis and endometriosis are unique among non-malignant gynecological diseases and provide fertile research topics. Ectopic endometrial tissues may have distinct molecular changes distinct from eutopic endometria despite having similar morphology. In this regard, there are intriguing suggestions as…

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Further Evidence that endometriosis is related to tubal or ovarian cancer - Togas Tulandi, MD

Further Evidence that endometriosis is related to tubal or ovarian cancer - Togas Tulandi, MD By Selma Oransay

Most authors suggest an association of endometriosis mainly with clear cell, low-grade serous, and endometrioid ovarian cancer.  But in two large cohort studies, no correlation between them is reported (Olson et al. 2002 and Tseng et al. 2019) Dr. Tulandi…

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Insoluble Dilemma of Adenomyosis: Diagnosis, Management, and Treatment  - Errico Zupi, MD

Insoluble Dilemma of Adenomyosis: Diagnosis, Management, and Treatment  - Errico Zupi, MD By Selma Oransay

The prevalence of adenomyosis has been reported to range from 1% to 70% in different studies. This large range can be explained by the lack of standard diagnostic criteria by imaging modalities or pathological analyses. Sixty-five% of the women with adenomyosis…

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Endometriosis and adenomyosis could be the “sides of the same coin”.

Endometriosis and adenomyosis could be the “sides of the same coin”. By Nasuhi Engin Aydin

The two common gynecological disorders, namely adenomyosis, and endometriosis are not settled yet, whether they are representing two different entities or different phenotypes of the same ailment. Dr. Maruyama and colleagues from Nara, Japan searched PubMed and Google Scholar electronic…

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All aspects of endometriosis reviewed with focus on modern management

All aspects of endometriosis reviewed with focus on modern management By Nasuhi Engin Aydin

Dr. Chapron and associates from academic centers in France published in Nature Review Endocrinology, a comprehensive review on endometriosis. The article is inclusive of all aspects of endometriosis but especially focuses on the management of the disease with its contemporary status.  Having a…

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The genetic mutations in uterine adenomyosis

The genetic mutations in uterine adenomyosis By Hale Goksever Celik

Adenomyosis is defined as the localization of endometrial stromal and glandular cells in the myometrium. This disease is a reproductive-aged women disease, like endometriosis. Additionally, adenomyosis is frequently observed together with endometriosis and leiomyomas due to common histological features and…

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A new ultrasound subgrouping reveals good clinical correlations in adenomyosis

A new ultrasound subgrouping reveals good clinical correlations in adenomyosis By Nasuhi Engin Aydin

Exacoustos and colleagues from two endometriosis tertiary referral centers in Rome, Italy published their observational, prospective study of the recently proposed transvaginal ultrasonographic scoring system in the "Journal of Minimally Invasive Gynecology". Adenomyosis or “endometriosis interna” is defined as the…

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Increased obstetrical complications after ART therapy in endometriosis patients.

Increased obstetrical complications after ART therapy in endometriosis patients. By Selma Oransay

To examine the impact of endometriosis and adenomyosis on ART therapy, Harada et al. from the Department of Obstetrics and Gynecology of Tottori University, Japan, planned a prospective cohort study and published their results recently in PLoS One.  The study…

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Inside to outside or from outside to inside?

Inside to outside or from outside to inside? By Nasuhi Engin Aydin

Pathogenesis of "adenomyosis", presence of the ectopic endometrium tissue within the uterine muscles, has largely been classically based on origin from basalis endometrium. Khan and associates from Japan have published their new conceptual findings on adenomyosis in Reproductive BioMedicine Online. In…

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New findings in adenomyosis (endometriosis interna) patients with potential theraupetic research implications

New findings in adenomyosis (endometriosis interna) patients with potential theraupetic research implications By Nasuhi Engin Aydin

Xue Shen and associates from Beijing, China have published their observations related to cannabinoid receptors, i.e., CB1 and CB2, in patients with adenomyosis, recently in the journal  "Biomed Research International".  Adenomyosis is an estrogen-dependent uterine disorder where a nonmalignant invasion…

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Adenomyosis (endometriosis interna): an enigmatic disease that has to be discovered yet

Adenomyosis (endometriosis interna): an enigmatic disease that has to be discovered yet By Nasuhi Engin Aydin

Scientists, Drs. Vannuccini and Petraglia from Italy have published an open access comprehensive review of Adenomyosis in "F1000Research" in March 2019 issue. Adenomyosis is a uterine disorder in which endometrial glands and stroma are pathologically demonstrated within the myometrium, i.e.…

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What clinicians know about adenomyosis? Any association with severe endometriosis?

What clinicians know about adenomyosis? Any association with severe endometriosis? By Selma Oransay

Dior et al. from the Royal Women's Hospital in Parkville, Australia, designed a prospective study to assess the association between severity of endometriosis and sonographic evidence of adenomyosis (SEOA) in their recently published article appearing in The Journal of Minimally…

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A novel neurotransmitter, Ninj1, has been found to be expressed in endometriosis

A novel neurotransmitter, Ninj1, has been found to be expressed in endometriosis By Irem Onur

Chronic inflammation is involved in the pathogenesis of endometriosis and adenomyosis, and inflammatory cytokines such as IL-1b are highly expressed in them. Inflammation and subsequent hyperinnervation are involved in the pathophysiology of pain generation. High levels of expression of various…

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Endometrioma and endometriosis

Endometrioma and endometriosis By Irem Onur

Exacoustos C. et al. published an article titled “The isolated ovarian endometrioma: a history between myth and reality” in the Journal of Minimally Invasive Gynecology in 2018. They aimed to examine the association between ovarian endometriomas detectable at the transvaginal ultrasound…

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The association between endometriosis, adenomyosis and preterm delivery

The association between endometriosis, adenomyosis and preterm delivery By Hale Goksever Celik

Endometriosis and adenomyosis are diseases of the same spectrum which have common features and coexist in some but not all patients. Both diseases are characterized by endometrial implants outside of the uterine cavity. Endometriosis is defined as the localization of…

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Fallopian Tube Capability in Women with Pelvic Endometriosis and Adenomyosis

Fallopian Tube Capability in Women with Pelvic Endometriosis and Adenomyosis By Kasthuri Nair

Xia et al. recently published a paper titled “Effects of pelvic endometriosis and adenomyosis on the ciliary beat frequency and muscular contractions in the human fallopian tube” in Reproductive Biology and Endocrinology. This research group primarily from Shanghai Jiaotong University…

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Benign Gynecological Tumors in Women with Endometriosis

Benign Gynecological Tumors in Women with Endometriosis By Kasthuri Nair

Matalliotaki et al. recently published a paper titled “Coexistence of benign gynecological tumors with endometriosis in a group of 1,000 women” in Oncology Letters. The study had two main objectives. The first goal was to understand the link between endometriosis…

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Diseases that Coexist with Adenomyosis and Endometriosis

Diseases that Coexist with Adenomyosis and Endometriosis By Kasthuri Nair

Adenomyosis, defined by endometrial glands and stroma found within the muscular uterine wall, and endometriosis are two common gynecological diseases that are similar pathologically and symptomatically. Choi et al. recently conducted a study where they hoped to determine the prevalence…

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