Endometriosis and Progesterone Resistance

Endometriosis and Progesterone Resistance By Selma Oransay

Progesterone resistance is the unresponsiveness of endometrium with subsequent dysregulation of the progesterone signaling pathway, and endometrial gene works. Progestins, on the other hand, are the first-line treatment choice, especially for long-term treatment of endometriosis. In the clinics, one-third of…

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Exploring the Potential Impact of Prenatal Testosterone on Endometriosis

Exploring the Potential Impact of Prenatal Testosterone on Endometriosis By Bahar Yuksel

The exact causes of endometriosis still remain uncertain but emerging evidence suggests that prenatal factors may contribute to its development. In the review study by Bernard J Cresp et al, the authors discuss the hormonal environment during prenatal development and…

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Predictability of IVF success by basal progesterone levels on patients with endometriosis

Predictability of IVF success by basal progesterone levels on patients with endometriosis By Bahar Yuksel

Endometriosis causes infertility in around 30-40% of all diagnosed women. Thus, strategies leading to more successful IVF results remain important. In the prospective study by Jovan Bila, the menstruation day 3 levels of serum progesterone were questioned to have a…

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The effect of postoperative hormonal medication preferences on the recurrence rate of endometrioma

The effect of postoperative hormonal medication preferences on the recurrence rate of endometrioma By Bahar Yuksel

Endometrioma is the most investigated type of endometriosis. The recurrence after surgery is important regarding its and reoperation’s effect on ovarian functions. In the study conducted by Seung-Hye Choi et al, the researchers questioned the effect of different postoperative hormonal…

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A novel contribution to patient management in endometriosis by immunohistochemistry

A novel contribution to patient management in endometriosis by immunohistochemistry By Nasuhi Engin Aydin

Dr. Tarumi and associates from the Kyoto Prefectural University of Medicine, Kyoto, Japan published their retrospective cohort study on the importance of progesterone receptors on recurring ovarian endometriosis in "The Journal of Clinical Endocrinology & Metabolism". Surgery for endometriosis is…

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An Overview on Treatment of endometriosis

An Overview on Treatment of endometriosis By Selma Oransay

There are different guidelines by different gynecological societies for the diagnosis and treatment of endometriosis, which is an extremely complex illness.  Kalaitzopoulos and Samartzis et al. from Switzerland worked on and compared six national and two international widely used guidelines to…

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Is it the new gold mine for endometriosis: oral GnRH antagonists

Is it the new gold mine for endometriosis: oral GnRH antagonists By Bahar Yuksel

Progestins and combined oral contraceptive pills are the first step hormonal options for women with endometriosis. But the more the use expands the more cases are seen with resistance to progestins. This gave birth to a need for different therapeutic…

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A hot research topic: macrophage reprogramming for endometriosis treatment

A hot research topic: macrophage reprogramming for endometriosis treatment By Nasuhi Engin Aydin

 Daria Artemova and colleagues from several research institutes of the Russian Federation have published their review on the cellular aspects of endometriosis related to macrophages, particularly emphasizing  promising therapeutic options for the future in "International Journal of Molecular Sciences". Macrophages have…

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Low-Dose Aspirin as a Potential Treatment for Endometriosis-Related Infertility

Low-Dose Aspirin as a Potential Treatment for Endometriosis-Related Infertility By Özge Özkaya

Treatment with low-dose aspirin could downregulate progesterone resistance and increase the expression of leukemia inhibitory factor (LIF) during the implantation window, according to a study that used a rat model of endometriosis. This, in turn, could improve endometrial receptivity and…

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Implantation failure in endometriosis patients - Jovana Lekovich, MD., PhD.

Implantation failure in endometriosis patients - Jovana Lekovich, MD., PhD. By Hale Goksever Celik

Endometriosis is one of the leading reasons for infertility due to decreased oocyte/embryo quality, fertilization ability, tubal function, and aberrant endometrial receptivity. Whether this failure is caused by oocyte/embryo or eutopic endometrium is one of the investigated topics in endometriosis…

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Progesterone Receptors and Endometriosis.

Progesterone Receptors and Endometriosis. By Ellen Tumimbang

Endometriosis is characterized as a chronic and inflammatory disease in which the specific cause has not been completely understood. Nonetheless, altered estrogen signaling and progesterone resistance are the common attributes of endometriosis. Progesterone resistance is partly attributed to a decrease…

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Cabergoline or Progesterone not Effective in Rat Model of Endometriosis

Cabergoline or Progesterone not Effective in Rat Model of Endometriosis By Özge Özkaya

Oral treatment with cabergoline or micronized progesterone for four weeks is not effective in the regression of endometriotic implants in a rat model of the disease. This is according to a study published in the "Journal of Investigative Surgery".  Cabergoline…

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Menstrual Blood Proteins for Endometriosis Diagnosis

Menstrual Blood Proteins for Endometriosis Diagnosis By Ellen Tumimbang

Endometriosis is a gynecological disorder characterized by endometrial tissue outside the uterine cavity. The backflow of menstrual blood from the uterus through the fallopian tubes is thought to be the cause of endometrial tissue growing outside the uterine cavity when…

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miR-92a and progesterone resistance in endometriosis

miR-92a and progesterone resistance in endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent disorder. This incidence of this disease is 35% to 50% among those who suffer from chronic pelvic pain and infertility, which has a negative effect on the quality of life and on health. Recent genome-wide associations…

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Steroid hormone receptors in endometriosis

Steroid hormone receptors in endometriosis By Yohan Suryo

Therapeutics that target the steroid hormones are the standard treatment for women with endometriosis because steroid hormones play an important role in endometrial physiology and pathogenesis of endometriosis. Examples of these therapeutics include anti-estrogens, estrogen receptor (ER) modulators, progestins, and…

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Regulation of Inflammation in Endometriosis

Regulation of Inflammation in Endometriosis By Dr. Youngran Park

Endometriosis is an estrogen-dependent and multifaceted gynecological condition. Unfortunately, this disease frequently causes chronic and cyclic pelvic pain. Though there are several treatments are available, there is not an actual cure for this disease. Therefore, the development of new therapy…

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A new target for the treatment of endometriosis?

A new target for the treatment of endometriosis? By Dr. Youngran Park

Endometriosis affects around 10% of women in reproductive age, estimating more than 176 million women worldwide. Inflammation in the pelvic cavity is very common in endometriosis patients. Therefore, there are high concentrations of cytokines and immune cells in the peritoneal…

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The Effect of Imbalanced Progesterone Receptors-A/B on Gelatinase Expressions in Endometriosis

The Effect of Imbalanced Progesterone Receptors-A/B on Gelatinase Expressions in Endometriosis By Dr. Youngran Park

Endometriosis is a benign disease which affects approximately 10% of reproductive-aged women and is one of the most common reasons for infertility. Though the underlying mechanisms of disease progression have not been clearly understood, it develops as a consequence of…

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The link between autoimmunity and endometriosis

The link between autoimmunity and endometriosis By Yu Yu

A popular model to explain the etiology of endometriosis is Sampson’s theory of retrograde menstruation. In this model, the viable endometrial tissue is spread and attached to the peritoneal cavity through the fallopian tubes during menstruation, resulting in an inflammatory…

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Endometriosis and nuclear receptors

Endometriosis and nuclear receptors By Dr. Youngran Park

It is well recognized that endometriosis is a steroid-dependent disorder. In endometrial stromal cells, progesterone regulates retinoic acid production and action. Retinoids also act via a number of nuclear receptors (NRs) and are involved in normal endometrial function and endometriosis. Estrogen…

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Progesterone Receptor Status in Endometriosis

Progesterone Receptor Status in Endometriosis By Serdar Balci

Some patients do not respond to progesterone hormone therapy. In this study recently published in the Journal of Clinical Endocrinology and Metabolism, the authors led by Hugh S. Taylor from the Department of Obstetrics, Gynecology and Reproductive Sciences from Yale…

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Will my Endometriosis Respond to Hormone Therapy?

Will my Endometriosis Respond to Hormone Therapy? By Özge Özkaya

Every woman has a different set of hormone receptors in the lining of their uterus. Yet, hormone-based therapies that are used to treat women with endometriosis do not take into consideration these differences among patients. Analyzing, which particular hormone receptors…

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Reason Why Hormone Therapy Alone Cannot Cure Endometriosis Uncovered

Reason Why Hormone Therapy Alone Cannot Cure Endometriosis Uncovered By Özge Özkaya

Researchers in Belgium have shed light on why hormone therapy cannot cure endometriosis on its own in a study published in the scientific journal Gynecological Endocrinology.  Their findings could shape the direction of future research and may help to find…

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EFA Medical Conference 2017: "Hormone and Cytokine Sensitivity in Endometriosis" Presentation by Dr. Robert Taylor

EFA Medical Conference 2017: By Kasthuri Nair

The first presenter of the “Estrogen from Inflammation to Cancer: A Distant Link?” section of EFA 2017 Medical Conference was Dr. Robert Taylor from Wake Forest University Health Sciences. Dr. Taylor’s presentation was titled “Hormone and Cytokine Sensitivity in Endometriosis.”…

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Progesterone resistance can cause endometriosis

Progesterone resistance can cause endometriosis By Demet Candaş Green

Progesterone is a steroid hormone produced by the corpus luteum of ovaries. Abnormal progesterone signaling (i.e., progesterone resistance) in the endometrium has been implicated in the establishment of eutopic and ectopic endometrial implants. Several causes for faulty progesterone signaling have been…

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Estrogen Receptor-β in Women’s Health

Estrogen Receptor-β in Women’s Health By Yu Yu

Since the discovery of estrogen receptor (ER), there has been a vast number of studies regarding its functions in cellular and physiological processes. The identification of estrogen receptor-β (ERβ), a second receptor, resulted in a much more complex understanding of the…

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A New Treatment Time-Table for Controlling Endometriosis-Associated Pelvic Pain

A New Treatment Time-Table for Controlling Endometriosis-Associated Pelvic Pain By Kasthuri Nair

It is no secret that Endometriosis is an extremely painful disease. Unfortunately, science has yet to determine a treatment that can effectively treat the disease or the associated pain. In their paper titled “Ethinylestradiol 20 mg/drospirenone 3 mg in a…

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CCL19/CCR7 Interaction can Casue Characteristic Cell Proliferation

CCL19/CCR7 Interaction can Casue Characteristic Cell Proliferation By Kasthuri Nair

In their paper published in the American Journal of Reproductive Immunology titled “CCL19/CCR7 contributes to the pathogenesis of endometriosis via PI3K/Akt pathway by regulating the proliferation and invasion of ESCs,” Diao et al. hope to elucidate one of the mechanisms…

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Updates in the Field of Endometriosis: Epigenetics

Updates in the Field of Endometriosis: Epigenetics By Kasthuri Nair

In this chapter titled “A Review of the Epigenetic Contributions to Endometriosis,” Grimstad and Decherney examine various epigenetic influences that drive endometriosis disease progression. The epigenetic alterations they discuss include DNA methylation, histone modification, chromatin architecture changes, nuclear receptor modulation,…

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Dienogest for endometriosis pain in clinical practice

Dienogest for endometriosis pain in clinical practice By Yu Yu

Dienogest is a synthetic progestogen that has been marketed as a medical treatment for endometriosis. Previous randomized controlled clinical trials have shown that it is effective in women with endometriosis at different stages of the disease. Given its recent introduction,…

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