An animal model of endometriosis reveals stress related disturbed vitamin D - vitamin D receptor axis

An animal model of endometriosis reveals stress related disturbed vitamin D - vitamin D receptor axis By Nasuhi Engin Aydin

Lopez and colleagues from academic institutions of Puerto Rico published their experimental endometriosis findings on female rats regarding the effect of stress on vitamin D-vitamin D receptor systems and recently published their findings in "Reproductive Sciences". The group previously showed…

Key Points Lay Summary

IL-33 Polarize Peritoneal Macrophages for Endometriosis Growth

IL-33 Polarize Peritoneal Macrophages for Endometriosis Growth By Nadire Duru

M2 type macrophages are the most common type of macrophages found in endometriosis and they enhance the development of endometriosis lesions. The key factors that stimulate macrophages to polarize towards M2 and contribute to the increased endometriosis lesions remain to be…

Key Points Lay Summary

The role of microbiota in the etiopathogenesis of endometriosis

The role of microbiota in the etiopathogenesis of endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent disease that is commonly diagnosed in reproductive-aged women. Although many advanced types of research about the etiology, differential diagnosis and treatment have been performed, it still remains an enigmatic disease. Dr. Bedaiwy, a scientist and physician…

Key Points Lay Summary

M1 and M2 macrophages in ovarian endometriomas

M1 and M2 macrophages in ovarian endometriomas By Yu Yu

Macrophages play an essential role in the immune response during inflammation and have been implicated in diseases such as inflammatory conditions and cancers. Broadly, macrophages are classified into M1 and M2. The M1 macrophages are pro-inflammatory, and in contrast, the…

Key Points Lay Summary

A Better Way to Diagnose Endometriosis?

A Better Way to Diagnose Endometriosis? By Özge Özkaya

Three proteins found in the blood and endometrial tissues could be used to determine the stage of endometriosis and the severity of painful periods according to a study published in the journal Current Medical Science. Evaluating the levels of these…

Key Points Lay Summary

Altered Immunity in Endometriosis

Altered Immunity in Endometriosis By Yu Yu

In recent years, there has been increased attention on the role of immune system in endometriosis development. Normally, immune reactions are supposed to destroy endometrial cells seeding in the peritoneal cavity. Nonetheless, in endometriosis, these cells are able to evade,…

Key Points Lay Summary

A review on the role of immune cells on the pathogenesis of endometriosis

A review on the role of immune cells on the pathogenesis of endometriosis By Murat Osman

Immune cells play a vital role in the homeostasis against infectious pathogens but also in the pathogenesis of endometriosis. Recent research has suggested that different immune cells have unique roles in this pathogenesis. Neutrophils, which are typically the primary acute…

Key Points Lay Summary

Interleukin 6 secretion from activated macrophages promotes the migration of endometriotic epithelial cells

Interleukin 6 secretion from activated macrophages promotes the migration of endometriotic epithelial cells By Dr. Youngran Park

Endometriosis is a chronic inflammatory disease. Accumulating evidence suggests that endometriosis patients have a higher level of various inflammatory factors which are associated with the pathogenesis of the disease. Several studies have shown marked increases in macrophage populations and activity…

Key Points Lay Summary

EFA Medical Conference 2017: "Hormone and Cytokine Sensitivity in Endometriosis" Presentation by Dr. Robert Taylor

EFA Medical Conference 2017: By Kasthuri Nair

The first presenter of the “Estrogen from Inflammation to Cancer: A Distant Link?” section of EFA 2017 Medical Conference was Dr. Robert Taylor from Wake Forest University Health Sciences. Dr. Taylor’s presentation was titled “Hormone and Cytokine Sensitivity in Endometriosis.”…

Key Points Lay Summary

A key cytokine in endometriosis can be targeted for endometriosis treatment

A key cytokine in endometriosis can be targeted for endometriosis treatment By Demet Candaş Green

Immune system dysfunction has been implicated in the development of endometriosis. One study showed that 95% of cells found in the peritoneal fluid of women with endometriosis are macrophages with impaired phagocytic function, which are unable to eat away unwanted…

Key Points Lay Summary

Interleukin-6 Involved in the Development of Endometriosis

Interleukin-6 Involved in the Development of Endometriosis By Özge Özkaya

A chemical produced by the body called Interleukin-6 (IL-6) and known to be involved in inflammation also seems to promote the development of endometriosis. This is according to a study by Chinese scientists published in the journal Medical Science Monitor.…

Key Points Lay Summary