Fallopian tube endometriosis
Endometriosis affects various tissues including pelvic and extra-pelvic organs. Fallopian tube endometriosis is not a widely studied topic in endometriosis, hence the real incidence is unknown as not all studies evaluate microscopically diagnosed Fallopian tube endometriosis. In the retrospective database…
Key Points Lay SummaryNon-coding RNAs and Endometriosis
Non-coding RNAs may have a fundamental role in the development of endometriosis. Non-coding transcripts have regulatory roles in the expression of protein-coding genes, thus regulate several signaling pathways. Based on their length, these non-coding RNAs are classified into two main classes:…
Key Points Lay SummaryCancer-associated mutations and endometriosis
Endometriosis is thought to benign gynecological disease. However, recent studies compiled in this review paper suggest that spontaneous somatic mutations are driven to occur during the cyclic bleeding resulting in endometriosis tissue undergoing repeated tissue injury and repair. Mutations are…
Key Points Lay SummarytRNA-derived fragments in ovarian endometriosis?
Endometriosis is an estrogen-dependent mysterious disorder characterized by the presence of endometrium outside the normal location of the uterus cavity. This disease affects approximately 10% of reproductive-aged women and becomes a major reason for infertility in reproductive-aged women and dysmenorrhea…
Key Points Lay SummaryThe genetic mutations in uterine adenomyosis
Adenomyosis is defined as the localization of endometrial stromal and glandular cells in the myometrium. This disease is a reproductive-aged women disease, like endometriosis. Additionally, adenomyosis is frequently observed together with endometriosis and leiomyomas due to common histological features and…
Key Points Lay SummaryThe prevalence and severity of endometriosis today
Ghiasi M. et al., a group of researchers from the USA, presented a comprehensive review of the prevalence, incidence, and stage of endometriosis worldwide as reported over the past 30 years. Researchers performed a search in four databases, including PubMed,…
Key Points Lay SummaryThe genetic predisposition to endometriosis
Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. Although endometrium is a non-malignant disease, its symptoms can range from mild to severe due to the inflammation that ectopic endometrial tissue forms around itself. The exact etiopathogenetic mechanism…
Key Points Lay SummaryNew Link Between Endometriosis and Genetics?
Two new genes have been identified that may be associated with endometriosis. This finding increases our understanding of the biology of endometriosis and may take us one small step further towards the development of new ways of treating the condition. …
Key Points Lay SummaryA new trial to reduce the failure of IVF/ICS protocols in severe endometriosis
Kong et al., from the first affiliated hospital of Zhengzhou University, China, recently published this single-blinded, a multicentered and randomized controlled study in the Journal of Reproductive Health, with the aim to find a safer and more effective ovulation induction regimen for patients with…
Key Points Lay SummaryThe miscarriage rate in women with endometriosis undergoing IVF fresh cycles
Endometriosis is a chronic estrogen-dependent disease diagnosed in 25-40% of women with infertility. There are several mechanisms explaining the negative impacts of endometriosis on fertility through the entire reproductive process such as sperm-oocyte interaction, ovarian reserve, and implantation. Endometriosis is…
Key Points Lay SummarySomatic mutations in iatrogenic endometriosis.
Lac and al., from the Department of Molecular Oncology in BC Cancer Research Center, Vancouver, Canada, planned a retrospective and multinational research to investigate the prevalence of somatic cancer-driver mutations in incisional endometriosis and recently published in the "Journal of Human Reproduction". Their…
Key Points Lay SummaryNew scientific evidence supporting robotic surgical approach to ureteric endometriosis
Surgical treatment of ureteral endometriosis aims to relieve urinary obstruction besides preserving renal functions. In accomplishing these, the best method of surgical approach is still unclear. Andrea Giannini and her colleagues from the University of Pisa, Italy conducted a retrospective…
Key Points Lay SummaryComorbidity Risks Among Women with Endometriosis
Evidence demonstrates that endometriosis is associated with higher rates of conditions such as ovarian and other gynecological cancers, thyroid cancer, autoimmune diseases, asthma/atopic diseases, and cardiovascular diseases. However, as findings remain fragmented, there is a need to assess these associations…
Key Points Lay SummaryEFA Medical Conference 2017: "NIH Funding - Present and Future" Presentation by Dr. Lisa Halvorson
Dr. Lisa Halvorson, the Chief at the Gynecologic Health and Disease Branch at the National Institute of Health (NIH)/NICHD/HHS, gave a presentation titled “NIH Funding - Present and Future” at the EFA 2107 Medical conference. Dr. Halvorson’s presentation began with…
Key Points Lay SummaryProtein-Modifying Variants in the Genome and Their Role in Endometriosis
The results of many endometriosis studies are limited in the fact that they only recruit patients from one geographical area; however, this particular study specifically narrowed their participant search to individuals from one continent, namely Europe. Sapkota et al. chose…
Key Points Lay SummaryThe Endometrium Itself is Genetically Different in Endometriosis Patients
Researchers in China identified a number of genes that are differentially expressed in the eutopic endometrium of women with endometriosis and those without. The researchers think that these genes may be involved in the development of endometriosis and that they…
Key Points Lay Summary