Clonal Proliferation and Cancer Associated Mutations in normal uterine endometrium and endometriosis

Clonal Proliferation and Cancer Associated Mutations in normal uterine endometrium and endometriosis By Serdar Balci

Suda et. al., from Niigata University, Japan, has published the article entitled "Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium" in Cell Reports. There are many theories for endometriosis development (retrograde menstruation, coelomic metaplasia, Müllerian remnants),…

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Somatic mutations in iatrogenic endometriosis.

Somatic mutations in iatrogenic endometriosis. By Selma Oransay

Lac and al., from the Department of Molecular Oncology in BC Cancer Research Center, Vancouver, Canada, planned a retrospective and multinational research to investigate the prevalence of somatic cancer-driver mutations in incisional endometriosis and recently published in the "Journal of Human Reproduction". Their…

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CARD10 and CARD11 Mutations: Another Piece of the Puzzle

CARD10 and CARD11 Mutations: Another Piece of the Puzzle By Kasthuri Nair

Zou et al., a research group from China, recently published a study titled “Analysis of CARD10 and CARD11 somatic mutations in patients with ovarian endometriosis” in Oncology Letters. The paper looked at the effects of caspase recruitment domain family member…

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Mutations Associated with Cancer Were Identified in "Endometriosis without Cancer"

Mutations Associated with Cancer Were Identified in By Özge Özkaya

Lesions in deep infiltrating endometriosis harbor genetic mutations that are associated with cancer, found a study published in the New England Journal of Medicine.  The authors believe that this new discovery may help to distinguish between aggressive and non-aggressive forms of…

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Unexpected "cancer-related" mutations in "non-cancerous" endometriosis: Do they predict aggressiveness?

Unexpected By Laura Ardighieri

A study supported by Endometriosis Foundation of America, reported by scientists from Johns Hopkins Medicine (Baltimore, USA) and the University of British Columbia (Vancouver, Canada) have identified the molecular alterations of deep infiltrating endometriosis trough a wide exome­ sequencing (protein-coding genetic alphabet…

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