Programmed-cell death pathway and immune dysfunction in endometriosis

Programmed-cell death pathway and immune dysfunction in endometriosis By Irem Onur

Endometriosis is an estrogen-dependent, immune-associated disease. Women with endometriosis have different proportions of the activated forms of immunocompetent cells, such as T cells and macrophages compared to those from women without. Immune cell dysfunction in the uterine and abdominal cavity…

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Drugs targeting estrogen biosynthesis opening up new approaches to the treatment of endometriosis.

Drugs targeting estrogen biosynthesis opening up new approaches to the treatment of endometriosis. By Selma Oransay

Gibson et al., from the Univerity of Edinburgh, UK, take over a new interest about endometriosis occurrence and progress by endometrial tissue intracrinology in their recently online published article in International Journal of Molecular Sciences. The authors summarize the last…

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Therapeutic potential of ginseng based compound in preclinical models of endometriosis

Therapeutic potential of ginseng based compound in preclinical models of endometriosis By Yu Yu

Currently, the drug option for women with endometriosis mainly focus on reducing estrogens levels (e.g., progestins, androgens, gonadotropin-releasing hormone (GnRH) agonists, and aromatase inhibitors). However, these therapies can have low effectiveness with frequent recurrence and considerable side effects. Therefore, there…

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An Alternative Medical Approach to Treat Endometriosis?

An Alternative Medical Approach to Treat Endometriosis? By Özge Özkaya

Molecules that act on a protein called SRC-1 could constitute a new medical tool to treat endometriosis, according to a study published in the Journal of Endocrinology.  SRC-1 makes certain parts of DNA more accessible therefore increasing gene expression or…

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Endometriosis in a Man as a Rare Source of Abdominal Pain

Endometriosis in a Man as a Rare Source of Abdominal Pain By Dr. Youngran Park

Endometriosis occurs when a tissue resembling endometrial glands and stroma grows in ectopic sites, commonly causing infertility and pain. Endometriosis has largely been found in women of reproductive age. However, in extremely rare cases, it is also found in men…

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Will my Endometriosis Respond to Hormone Therapy?

Will my Endometriosis Respond to Hormone Therapy? By Özge Özkaya

Every woman has a different set of hormone receptors in the lining of their uterus. Yet, hormone-based therapies that are used to treat women with endometriosis do not take into consideration these differences among patients. Analyzing, which particular hormone receptors…

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A clearer picture of "endometriosis after menopause"

A clearer picture of By Irem Onur

Delfin Avendano Tan and Marie Josephine Guanlao Almeria are obstetrician-gynecologists from the Philippines. They recently published a review article titled "Postmenopausal endometriosis: drawing a clearer picture". In this paper, the authors discussed the pathogenesis, risk factors, and management of postmenopausal…

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Therapeutic strategies involving uterine stem cells in reproductive medicine

Therapeutic strategies involving uterine stem cells in reproductive medicine By Murat Osman

Stem cells are undifferentiated cells that often serve to regenerate tissue in states of injury or apoptosis. The endometrium has progenitor cells that replace tissue lost after each menstrual cycle. It has been postulated that excessive stem cell recruitment to…

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Role of GATA6 in Endometriosis

Role of GATA6 in Endometriosis By Özge Özkaya

Researchers discovered that a protein called GATA6 is crucial in turning endometrial stromal cells into endometriotic-like cells, which may be capable of invading surrounding tissues and growing outside the uterus.  This knowledge can be used to create cell models that…

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Enhanced UGT1A1 Gene and Protein Expression in Endometriotic Lesions.

Enhanced UGT1A1 Gene and Protein Expression in Endometriotic Lesions. By Dr. Youngran Park

The estrogen plays an essential role in endometriosis. Lately, it is becoming evident that, besides the circulating levels of estrogens, the balance of synthesis versus inactivation (metabolism) of estrogens by intralesional steroid-metabolizing enzymes also determines the local net estrogen availability.…

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Reason Why Hormone Therapy Alone Cannot Cure Endometriosis Uncovered

Reason Why Hormone Therapy Alone Cannot Cure Endometriosis Uncovered By Özge Özkaya

Researchers in Belgium have shed light on why hormone therapy cannot cure endometriosis on its own in a study published in the scientific journal Gynecological Endocrinology.  Their findings could shape the direction of future research and may help to find…

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Estrogen receptor splice variants may be associated with endometriosis pathogenesis and clinical severity.

Estrogen receptor splice variants may be associated with endometriosis pathogenesis and clinical severity. By Murat Osman

Endometriosis is defined as the presence of uterine stroma and glands outside of the uterine cavity and is one of the leading causes of chronic pelvic pain in women. Thus, understanding key genetic markers of this disease and evaluating those…

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A Potential New Drug for Endometriosis?

A Potential New Drug for Endometriosis?  By Özge Özkaya

A steroid derivative called PBRM could be a new emerging drug to treat endometriosis according to a study by Canadian scientists. In the study that was published in The Journal of Steroid Biochemistry and Molecular Biology, researchers characterized the pharmaceutical…

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Hormonal Contraceptives and the Risk of Breast Cancer

Hormonal Contraceptives and the Risk of Breast Cancer By Kasthuri Nair

A study titled “Contemporary Hormonal Contraception and the Risk of Breast Cancer” was recently published in The New England Journal of Medicine and was immediately picked up and summarized by many well-known newspapers and broadcasting journals, including but not limited…

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Increased Period Pain in Endometriosis Is Linked to Estrogen

Increased Period Pain in Endometriosis Is Linked to Estrogen By Özge Özkaya

Researchers in China shed light on the mechanism of how the female sex hormone estrogen may be linked to increased period pain in women with endometriosis. A better understanding of the biological mechanism leading to pelvic pain in endometriosis could…

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EFA Medical Conference 2017: "Breast Cancer in Young Women; Early Diagnosis Timely Intervention" Presentation by Dr. Stephanie Bernik

EFA Medical Conference 2017: By Kasthuri Nair

Dr. Stephanie Bernik is the Chief of Surgical Oncology of Surgery and General Surgery at the Lenox Hill Hospital. She recently presented at the EFA 2017 Medical Conference, and her presentation was titled “Breast Cancer in Young Women; Early Diagnosis…

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Reducing side effect of estrogen based therapy by using Tissue-Selective Estrogen Complex

Reducing side effect of estrogen based therapy by using Tissue-Selective Estrogen Complex By Yu Yu

The aberrant regulation of the ERα level in endometriosis and other estrogen-related diseases makes it a promising target for therapy. However, the standard beneficial roles of estrogen in specific target tissues, e.g., the bone, can be primarily affected by such…

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Estrogen Receptor-β in Women’s Health

Estrogen Receptor-β in Women’s Health By Yu Yu

Since the discovery of estrogen receptor (ER), there has been a vast number of studies regarding its functions in cellular and physiological processes. The identification of estrogen receptor-β (ERβ), a second receptor, resulted in a much more complex understanding of the…

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An update of estrogen receptors on human disease

An update of estrogen receptors on human disease By Yu Yu

Estrogens and its receptors influence numerous human physiological processes. Two estrogen receptors exist, including estrogen receptor α (ERα) and ERβ. Hence, it is essential to elucidate the functions of these receptors in healthy and diseased states. This is particularly important…

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A New Treatment Time-Table for Controlling Endometriosis-Associated Pelvic Pain

A New Treatment Time-Table for Controlling Endometriosis-Associated Pelvic Pain By Kasthuri Nair

It is no secret that Endometriosis is an extremely painful disease. Unfortunately, science has yet to determine a treatment that can effectively treat the disease or the associated pain. In their paper titled “Ethinylestradiol 20 mg/drospirenone 3 mg in a…

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Updates in the Field of Endometriosis: Epigenetics

Updates in the Field of Endometriosis: Epigenetics By Kasthuri Nair

In this chapter titled “A Review of the Epigenetic Contributions to Endometriosis,” Grimstad and Decherney examine various epigenetic influences that drive endometriosis disease progression. The epigenetic alterations they discuss include DNA methylation, histone modification, chromatin architecture changes, nuclear receptor modulation,…

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Combination Polymorphisms of Three "Estrogene-Related" Genes Increase the Risk of Endometriosis

Combination Polymorphisms of Three By Kasthuri Nair

Cardoso et al. recently published a paper titled “Combined Effect of the PGR +331C > T, CYP17A1 -34A > G and CYP19A1 1531G > A Polymorphisms on the Risk of Developing Endometriosis” in Revista brasileira de ginecologia e obstetrician. The…

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Dienogest for Endometriosis

Dienogest for Endometriosis By Kasthuri Nair

Laganà et al. recently published an article in Expert Opinion on Drug Metabolism & Toxicology titled “Clinical dynamics of Dienogest for the treatment of endometriosis: from bench to bedside.” This article explored the benefits of using Dienogest, a progestin, to…

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Reevaluating response and failure of medical treatment of endometriosis

Reevaluating response and failure of medical treatment of endometriosis By Elisabetta Kuhn

Endometriosis is a chronic disease affecting more than 10% of women in the fertile age and causing "pain" symptoms, that may require medical therapy. Most medical treatments used for endometriosis exert a hormonal mechanism to curtail estrogen effects either locally…

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Is it Estrogen that Regulates Endometriosis Pain?

Is it Estrogen that Regulates Endometriosis Pain? By Yu Yu

Endometriosis-associated pain is a debilitating condition; however, it is surprising that the perceived pain has no correlation to the endometriosis extent. The mechanism that causes the pain is also poorly understood. Nerve growth factor is enhanced in endometriosis and may increase…

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How ERα is regulated in endometriosis?

How ERα is regulated in endometriosis? By Yu Yu

Endometriosis pathogenesis is largely influenced by estrogen. Ectopic endometrium has altered expression of ERα compared to the eutopic endometrium. It is unclear what biological processes regulate such alteration. The article by Toderow et al. in Archives of Gynecology and Obstetrics…

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Female Sex Hormone Necessary but not Enough to Cause Endometriosis

Female Sex Hormone Necessary but not Enough to Cause Endometriosis By Özge Özkaya

Estrogen, the primary female sex hormone may be necessary but is not enough to induce endometriosis, found a study published in the Journal of Bioscience.   This finding is important because it can help scientists better understand factors that cause endometriosis…

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