By Eylül GÜNHypoxia and endometriosis: A review of mechanisms
By Eylül GÜN
Various mechanisms have been suggested to explain the development of endometriosis lesions. One of these is hypoxia, which can induce changes in endometrial cells, but the exact mechanism is not yet clear. Zhou et al from China wrote a review…
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By Nasuhi Engin AydinPreferential expression of some membrane type matrix metalloproteinase proteins
By Nasuhi Engin Aydin
Dr. Maoga and associates from academic institutions located in Germany and Kenya have published their findings on the immunohistochemical expression of MT-MMP proteins, namely MT2-MMP (MMP15) and MT3-MMP (MMP16) in the eutopic endometrium of healthy and endometriotic patients; and also…
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Matrix metalloproteinases and their role in endometriosis
By Eylül GÜN
The extracellular matrix harbors important macromolecules such as collagen and glycoproteins which are required for tissue remodeling, differentiation, and homeostasis. The main group of enzymes responsible for these properties is called matrix metalloproteinases (MMPs). It has been proven that MMPs…
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By Hale Goksever CelikBody Mass Index and indicators of metabolic syndrome in women with Endometriosis
By Hale Goksever Celik
Endometriosis is a disease of reproductive-aged women and has common pathophysiological mechanisms with other chronic health morbidities due to its estrogen-dependent chronic inflammatory background. The changes in the inflammatory components of adipose tissue may have an impact on the quality of…
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Retinol-binding protein in endometriosis pathogenesis
By Nasuhi Engin Aydin
Dr. Jae Chul Lee and associates from the Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, have published the recent results of their research on endometriosis regarding the role of retinol-binding protein4…
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By Ellen TumimbangA pilot study for Endometriosis Potential biomarkers
By Ellen Tumimbang
Endometriosis is one of the most common female health disorders typically causing dysmenorrhea, dyspareunia, and pelvic pain, and may contribute to infertility. It is necessary to identify potential molecular biomarkers for diagnosis and regulatory factors behind the disease. The study…
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By Dr. Youngran ParkImmune cells and endometriosis pain
By Dr. Youngran Park
Endometriosis is an estrogen-dependent inflammatory disorder in women. This disease leads to dysmenorrhea, pelvic pain, and infertility. The immune reaction is one of the most widely accepted pathologies of endometriosis. Estrogen dysfunction stimulates immune cells in the peritoneal cavity affecting…
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By Yu YuEndometriosis signaling: the role of IL-34
By Yu Yu
An increasing number of studies have suggested that the pathogenesis of endometriosis is mediated by cytokines, such as interleukin (IL)−17, which promoted the formation and progression of endometriosis by up-regulating angiogenesis and pro-inflammatory cytokines secretion. IL-34 is a newly described…
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By Özge ÖzkayaNew Protein for Endometriosis Diagnosis
By Özge Özkaya
A protein called TIMP3 (tissue inhibitor of metalloproteinase-3) could be used for the diagnosis and prognosis (likely course) of endometriosis. The early diagnosis of endometriosis is of paramount importance because it can help to diagnosis and thus initiate the right…
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By Selma OransaySearching new biomarkers for endometriosis
By Selma Oransay
This recent article published in Advances in Clinical Chemistry, is an overall summary of characteristics, physiopathological theories, diagnostic approaches and variety of biomarkers to diagnose endometriosis and penned by Coutinho et al. from Universidade Federal de Juiz de Fora, Belo Horizonte,…
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A link between endometrioid ovarian carcinoma and endometriosis.
By Selma Oransay
Ciavattini et al.from Polytechnic University Ancona, Italy create a pilot study which recently published in Oncology Letters to clarify the link between endometriosis and endometrioid ovarian cancer. The unfolded protein response (UPR) activity as a promoter of neoplastic progression of malignancies is…
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By Kasthuri NairAutophagy, proteolysis and Endometriosis
By Kasthuri Nair
Sui et al., a group of researchers from the Qiqihar Medical University and Qilu Hospital of Shandong University, recently published in Experimental and Therapeutic Medicine. The piece titled “Expression and significance of autophagy genes LC3, Beclin1 and MMP-2 in endometriosis”…
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By Murat OsmanA Balancing Act: How Endometriosis Invades the Body
By Murat Osman
Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterine cavity. Ectopic endometrial tissues have been shown to have some features that mimic malignancy. For example, endometriosis can invade surrounding structures and attach to surfaces such…
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Polymorphism of IL12B May Help Solve Endometriosis
By Kasthuri Nair
Zhao et al. recently published a paper titled “A functional promoter polymorphism in interleukin 12B gene is associated with an increased risk of ovarian endometriosis” in Gene. The research group from Hebei Medical University wanted to explore the potential roles…
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A Potential New Target for the Treatment of Endometriosis
By Özge Özkaya
A protein called STIP1 could be facilitating the migration of endometrial tissue outside the uterus, therefore, leading to endometriosis according to a study by Taiwanese researchers. The protein could, thus, be used as a potential therapeutic target for endometriosis. For…
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Biomarker Networks Might Help Reveal the Mechanism Behind Endometriosis
By Kasthuri Nair
Scientists have yet to uncover the molecular mechanisms that promote endometriosis disease progression. Xiao et al. recently published a study in Experimental and Therapeutic Medicine where they hoped to shed new light on the pathogenesis of endometriosis. In their study…
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Changes in Complement Proteins Affect Infertility in Women with Endometriosis
By Kasthuri Nair
Palomino et al. recently published a paper titled “The endometria of women with endometriosis exhibit dysfunctional expression of complement regulatory proteins during the mid-secretory phase” in the Journal of Reproductive Immunology where they look at the expression of CRPs during the menstrual cycle of…
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Mitogen-Activated Protein Kinase p38 modulates Inflammation in Endometriosis
By Yu Yu
The p38 mitogen-activated protein kinase (MAPK) is a serine/threonine kinase, which transduces signals within the cell in response to various environmental stimuli. In doing so, it mediates intracellular signaling of cytokine production, cell proliferation, and apoptosis amongst many other cellular…
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The Endometrium Itself is Genetically Different in Endometriosis Patients
By Özge Özkaya
Researchers in China identified a number of genes that are differentially expressed in the eutopic endometrium of women with endometriosis and those without. The researchers think that these genes may be involved in the development of endometriosis and that they…
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Could the cell surface protein "EWI-2" be the new diagnostic marker for endometriosis?
By Murat Osman
Further Understanding: Researchers from the Reproductive Medicine Center of Wuhan University sought to observe the differential expression of EWI-2, (a cell surface protein and an early activation marker, also known as IGSF8 - Immunoglobulin superfamily member 8) in 145 women…
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