Non-coding RNAs and Endometriosis

Non-coding RNAs and Endometriosis By Ellen Tumimbang

Non-coding RNAs may have a fundamental role in the development of endometriosis. Non-coding transcripts have regulatory roles in the expression of protein-coding genes, thus regulate several signaling pathways. Based on their length, these non-coding RNAs are classified into two main classes:…

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Cancer-associated mutations and endometriosis

Cancer-associated mutations and endometriosis By Ellen Tumimbang

Endometriosis is thought to benign gynecological disease. However, recent studies compiled in this review paper suggest that spontaneous somatic mutations are driven to occur during the cyclic bleeding resulting in endometriosis tissue undergoing repeated tissue injury and repair. Mutations are…

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tRNA-derived fragments in ovarian endometriosis?

tRNA-derived fragments in ovarian endometriosis? By Dr. Youngran Park

Endometriosis is an estrogen-dependent mysterious disorder characterized by the presence of endometrium outside the normal location of the uterus cavity. This disease affects approximately 10% of reproductive-aged women and becomes a major reason for infertility in reproductive-aged women and dysmenorrhea…

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The genetic mutations in uterine adenomyosis

The genetic mutations in uterine adenomyosis By Hale Goksever Celik

Adenomyosis is defined as the localization of endometrial stromal and glandular cells in the myometrium. This disease is a reproductive-aged women disease, like endometriosis. Additionally, adenomyosis is frequently observed together with endometriosis and leiomyomas due to common histological features and…

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The genetic predisposition to endometriosis

The genetic predisposition to endometriosis By Hale Goksever Celik

Endometriosis is an estrogen-dependent gynecological disease mostly encountered in reproductive-aged women. Although endometrium is a non-malignant disease, its symptoms can range from mild to severe due to the inflammation that ectopic endometrial tissue forms around itself. The exact etiopathogenetic mechanism…

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New Link Between Endometriosis and Genetics?

New Link Between Endometriosis and Genetics? By Özge Özkaya

Two new genes have been identified that may be associated with endometriosis. This finding increases our understanding of the biology of endometriosis and may take us one small step further towards the development of new ways of treating the condition. …

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Somatic mutations in iatrogenic endometriosis.

Somatic mutations in iatrogenic endometriosis. By Selma Oransay

Lac and al., from the Department of Molecular Oncology in BC Cancer Research Center, Vancouver, Canada, planned a retrospective and multinational research to investigate the prevalence of somatic cancer-driver mutations in incisional endometriosis and recently published in the "Journal of Human Reproduction". Their…

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Protein-Modifying Variants in the Genome and Their Role in Endometriosis

Protein-Modifying Variants in the Genome and Their Role in Endometriosis By Kasthuri Nair

The results of many endometriosis studies are limited in the fact that they only recruit patients from one geographical area; however, this particular study specifically narrowed their participant search to individuals from one continent, namely Europe. Sapkota et al. chose…

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The Endometrium Itself is Genetically Different in Endometriosis Patients

The Endometrium Itself is Genetically Different in Endometriosis Patients By Özge Özkaya

Researchers in China identified a number of genes that are differentially expressed in the eutopic endometrium of women with endometriosis and those without. The researchers think that these genes may be involved in the development of endometriosis and that they…

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