By Selma OransayWomen's willingness to donate menstrual blood for endometriosis research
By Selma Oransay
The menstrual blood is 50-100 ml/per cycle, with 80% lost during the first three days. On the heaviest bleeding day, 2 to 8 ml may be collected from a cup worn for four hours. This fluid could be investigated by…
Key Points Lay Summary
Early diagnosis of deep infiltrating endometriosis in adolescence
By Selma Oransay
Dysmenorrhea is widely observed in adolescence, and endometriosis is one of its causes. However, endometriosis diagnosis is usually made after 25 years of age. It is clear that early diagnosis and management of this progressive disease is essential and will…
Key Points Lay Summary
Peritoneal fluid in young women with endometriosis
By Selma Oransay
Many blood substances are present in peritoneal fluid due to their derivation from the transudation of blood through the peritoneal surface. Ectopic endometriotic lesions can also change the medium to contribute to the definition of the local environment of the…
Key Points Lay Summary
By Eylül GÜNAssessing endometrial receptivity using menstrual blood samples in patients undergoing in-vitro fertilization
By Eylül GÜN
Endometrial receptivity is the endometrium's capacity to allow the embryo the chance to adhere, infiltrate, and develop while ensuring an ideal microenvironment. When impaired, it is one of the two major factors contributing to infertility along with embryo quality by…
Key Points Lay Summary
By Özge ÖzkayaWomen With Endometriosis More Likely to Also Have Non-Specific Symptoms
By Özge Özkaya
Women with endometriosis are more likely to report menstrual symptoms, according to a new study published in the American Journal of Obstetrics and Gynecology. However, they are also at an increased risk of mental health disorders, other pain symptoms, bowel,…
Key Points Lay Summary
By Hale Goksever CelikThe most common gynecologic admissions to the emergency: Endometriosis and adenomyosis
By Hale Goksever Celik
Women with endometriosis demand therapy for the most common symptoms, which are pelvic pain and infertility. Adenomyosis occurs when the endometrial glandular and stromal tissue grows into the muscular wall of the uterus, called the myometrium. Women having adenomyosis also…
Key Points Lay Summary
Endometriosis and IBS Have Different Comorbidities
By Özge Özkaya
Comorbidities of endometriosis and irritable bowel syndrome (IBS) are different despite several overlapping symptoms, according to a new study published in the scientific journal Human Reproduction. These comorbidities are usually related to the organ systems that are primarily involved in…
Key Points Lay Summary
Non-invasive Construction of Endometrial Organoids
By Eylül GÜN
Organoids are 3D culture structures established in vitro and they reflect the aspects of the tissue or the organ they represent. They are seen as important tools in the evaluation of normal development, disease course, and the prediction of the…
Key Points Lay Summary
Endometriosis & adolescents: Overcoming the diagnostic delay via education
By Eylül GÜN
Although the diagnosis of endometriosis is still not timely even in adults, due to its common under- or misdiagnosis in adolescents, the diagnostic delay may further cause the adolescent women to wait to seek medical treatment. A group of researchers…
Key Points Lay Summary
By Timur SeckinBody mass index, the incidence of endometriosis and the severity of dysmenorrhoea
By Timur Seckin
According to a case-control study conducted by researchers from China, there is no association between body mass index (BMI) and the incidence of endometriosis. This finding contrasts with the conventional knowledge that low BMI is a risk factor for endometriosis.…
Key Points Lay Summary
By Yu YuEndometriotic mesenchymal stem cells may promote endometriosis
By Yu Yu
The cause of endometriosis is still debatable. Many researchers have accepted that retrograde menstruation, where the endometrial fragments released during menstruation attach and colonize the ectopic locations, is the most plausible reason. However, the numbers just do not add up.…
Key Points Lay Summary
Adolescent dysmenorrhea diagnosis and management
By Hale Goksever Celik
Endometriosis is usually diagnosed in reproductive-aged women. However, recent literature proved that clinical symptoms of endometriosis are also seen the adolescent girls and young women. Dysmenorrhea, the most common gynecologic complaint among this age group, can develop due to endometriosis.…
Key Points Lay Summary
By Nadire DuruCase-control study to develop a questionnaire for early diagnosis of endometriosis
By Nadire Duru
Endometriosis, which affects 5–10% of women of reproductive age, is a chronic gynecological disease characterized by the presence of endometrial glands and stroma outside the uterus, associated with several discomforts such as pelvic pain, menstrual disorders, and infertility. Ultrasound evaluation…
Key Points Lay Summary
How Long Does it Take to Be Diagnosed with Endometriosis?
By Özge Özkaya
It takes a median of eight years to reach a diagnosis of endometriosis from when the symptoms of the condition first appear confirmed a new British study. Interestingly, it seems that the earlier the symptoms appear, the later the disease…
Key Points Lay Summary
Patients preferences for the treatment of endometriosis-associated pain
By Hale Goksever Celik
Endometriosis is defined as the location of endometrial stroma and glands outside the uterine cavity. The most common presenting complaints are mainly dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility, most of which relate to the menstrual period. Those women affected…
Key Points Lay Summary
Adolescent dysmenorrhea and future endometriosis
By Selma Oransay
Dysmenorrhoea is typically classified as primary, or secondary due to underlying pathologies like fibroids, endometriosis, adenomyosis or uterine anomalies. Generally, long-term dysmenorrhea is present in endometriotic patient's anamnesis, but until recently, the research to clarify this connection remained retrospective. Knox et…
Key Points Lay Summary
Menstrual blood-derived stem cells
By Selma Oransay
Chen et al. from the Center of Diagnosis and Treatment of İnfectious Disease, Zhejiang University, China penned this recent review in the Journal of Stem Cell Research Therapy which is presenting the clinical potential of MenSCs (Menstrual blood-derived stem cells). …
Key Points Lay Summary
Is the mystery for progression of endometriosis hiding out in abnormally located endometrial cells?
By Selma Oransay
This prospective study was conducted by Hapangama et al. in Research İnstute of the University of Liverpool, UK, and the results have recently published in the Journal of Human Reproduction. The authors hypothesized that abnormally located endometrial basalis-like (SSEA1/nSOX9+)cells could be contributing to…
Key Points Lay Summary
Could Endometriosis Be Caused by Bacteria?
By Özge Özkaya
A new concept called the bacterial contamination hypothesis in endometriosis has been proposed for the first time by researchers in Japan. This means that new potential therapies approaches could exist for this condition in addition to the conventional estrogen-suppressing therapies.…
Key Points Lay Summary
By Kasthuri NairMenstrual Effluent Can Change the Future of Endometriosis
By Kasthuri Nair
During Endometriosis Awareness Month, Warren et al. published a paper entitled “Analysis of menstrual effluent: diagnostic potential for endometriosis” in Molecular Medicine. This paper relies heavily on the theory of retrograde menstruation, where menstrual effluent flows into the peritoneal cavity.…
Key Points Lay Summary
Is there any association between menstrual pain and ovarian cancer?
By Yu Yu
Inflammation may be important in ovarian carcinogenesis. Epidemiological studies show that inflammatory conditions such as endometriosis and pelvic inflammatory disease have been associated with an increased risk of ovarian cancer, while regular use of non-steroidal anti-inflammatory drugs has reduced associated…
Key Points Lay Summary
Glycodelin and altered endometrial function in endometriosis
By Yu Yu
A laparoscopic examination is the only diagnostic tool for endometriosis to date. Since the procedure is invasive, there has been much effort by researchers to develop a biomarker for non-invasive diagnosis of endometriosis. To this end, there has been growing…
Key Points Lay Summary
By Murat OsmanRetinoic Acid Signaling Involved in Endometrial Decidualization
By Murat Osman
Decidualization occurs in the eutopic endometrium during the luteal phase and is controlled by signaling pathways such as cyclic adenosine monophosphate (cAMP) and progesterone. Researchers from the Northwestern University School of Medicine reported in their recent paper entitled "Altered Retinoid…
Key Points Lay Summary
TFF3 May Be Involved in Endometriosis Research Suggests
By Özge Özkaya
Levels of a protein called TFF3 are significantly increased in the peritoneal cavity (the abdominal space) of women with endometriosis, found a study published in the scientific journal Reproductive Sciences. This increase was in line with levels of other known…
Lay Summary
Elagolix (ABT-620) for endometriosis pain?
By Yu Yu
Elagolix is an orally active gonadotropin-releasing hormone antagonist that has just recently completed Phase 3 clinical trial for endometriosis-associated pain (NCT01931670). The review article by Alessandro et al in Archives of Gynecology and Obstetrics summarized the current research findings on…
Key Points Lay Summary