Antioxidant Enzymes in Endometriosis

Antioxidant Enzymes in Endometriosis By Dr. Youngran Park

Recent attention has been focused on the effect of oxidative stress in the development of endometriosis. Especially, there are several studies regarding glutathione peroxidase (GPX), a major enzyme in removing various reactive oxygen species. In the field of infertility, the…

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NAT2 as potential biomarker for the diagnosis and treatment of endometriosis

NAT2 as potential biomarker for the diagnosis and treatment of endometriosis By Nadire Duru

Endometriosis affects 5–10% of women of reproductive age causing several discomforts, pelvic pain, menstrual disorders, ectopic bleeding, infertility, and sometimes even malignant transformation but its etiology remains unclear. Accumulating evidence point a key role for genetic factors and there is…

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Polymorphisms and endometriosis: a systematic review and meta-analyses.

Polymorphisms and endometriosis: a systematic review and meta-analyses. By Yohan Suryo

The symptoms of endometriosis are varied among women and include chronic pelvic pain, infertility, and fatigue. There are no reliable blood tests and medical imaging techniques such as MRI and ultrasound are not always satisfactory. The lack of endometriosis-specific symptoms…

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DNA repair defects and Endometriosis

DNA repair defects and Endometriosis By Dr. Youngran Park

Endometriosis is a hormone-dependent disorder and highly associated with inflammation. It is well suggested that endometriosis increases the risks of developing cancers such as ovarian, breast, endocrine, and colorectal cancers. Compared to cancer, there are many similarities in endometriosis. Well-known characteristics…

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Another Genetic Polymorphism That May Increase Risk of Endo

Another Genetic Polymorphism That May Increase Risk of Endo By Özge Özkaya

A single letter change in the Epidermal Growth Factor Receptor (EGFR) gene may significantly increase the risk of endometriosis.  This is according to a study conducted among women in Southwest China and published in the journal Medicine. Identifying genetic risk…

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Polymorphisms of STAT4 gene in the pathogenesis of endometriosis

Polymorphisms of STAT4 gene in the pathogenesis of endometriosis By Dr. Youngran Park

Endometriosis is one of the most common gynecological diseases in reproductive-age women characterized by the occurrence of endometrial tissue outside the uterine cavity. Researchers have put forward numerous hypotheses to explain ectopic endometrial tissue, and the bulk of the evidence…

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Could Endometriosis-Related Infertility Be Genetic?

Could Endometriosis-Related Infertility Be Genetic? By Özge Özkaya

Researchers identified genetic polymorphisms or individual differences in two genes called AMA5 and KAZN among women with endometriosis who were infertile and control women who were fertile. The identification of these polymorphisms could help scientists better understand why some women…

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Molecular Susceptibility to Endometriosis

Molecular Susceptibility to Endometriosis By Kasthuri Nair

Fayez et al., a group of researchers from various institutions in Iran, recently published a paper in the Avicenna Journal of Medical Biotechnology titled “Arylamine N-acetyltransferase 2 Polymorphisms and the Risk of Endometriosis.” This study focused on the relationship between…

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Polymorphism of IL12B May Help Solve Endometriosis

Polymorphism of IL12B May Help Solve Endometriosis By Kasthuri Nair

Zhao et al. recently published a paper titled “A functional promoter polymorphism in interleukin 12B gene is associated with an increased risk of ovarian endometriosis” in Gene. The research group from Hebei Medical University wanted to explore the potential roles…

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Endometriosis-related Mitochondrial DNA Control Region Polymorphisms Found in Brazil

Endometriosis-related Mitochondrial DNA Control Region Polymorphisms Found in Brazil By Kasthuri Nair

The genetic basis for the formation of endometriosis is still at large. Andres et al. from the University of Sao Paulo, Brazil,  looked at various individuals, with and without endometriosis, to determine polymorphisms in the mitochondrial DNA (mtDNA) control region that…

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Combination Polymorphisms of Three "Estrogene-Related" Genes Increase the Risk of Endometriosis

Combination Polymorphisms of Three By Kasthuri Nair

Cardoso et al. recently published a paper titled “Combined Effect of the PGR +331C > T, CYP17A1 -34A > G and CYP19A1 1531G > A Polymorphisms on the Risk of Developing Endometriosis” in Revista brasileira de ginecologia e obstetrician. The…

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