Autophagy, proteolysis and Endometriosis

Autophagy, proteolysis and Endometriosis By Kasthuri Nair

Sui et al., a group of researchers from the Qiqihar Medical University and Qilu Hospital of Shandong University, recently published in Experimental and Therapeutic Medicine. The piece titled “Expression and significance of autophagy genes LC3, Beclin1 and MMP-2 in endometriosis”…

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Inhibition of PI3K/AKT/mTOR pathway for the treatment of endometriosis.

Inhibition of PI3K/AKT/mTOR pathway for the treatment of endometriosis. By Dr. Youngran Park

Dr. Matsuzaki et al. (2018) published a paper entitled ‘In vitro and in vivo effects of MK2206 and chloroquine combination therapy on endometriosis’ showing that the efficacy of MK2206, an Akt inhibitor, in combination with chloroquine for inducing autophagy in…

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Is there a new hope for the prevention of endometriotic invasions?

Is there a new hope for the prevention of endometriotic invasions? By Selma Oransay

This research which recently published in Biomed Research International is performed by Xiaomei et al. from Obst/Gyn, Pathology and Genetic departments of three hospitals in Changsha, CHINA. The authors planned a prospective and controlled biochemical study to specify the role…

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Commentary on major developments in the pathophysiology of endometriosis

Commentary on major developments in the pathophysiology of endometriosis By Engin Aydin

This commentary article by Dr. Warren G. Foster, from MacMaster University, Canada that appeared at Biology of Reproduction, is highly valuable for its leading role in endometriosis research. Although endometriosis is a common disease affecting up to 10% of women,…

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HOXA10: A Culprit in Endometriosis Disease Progression

HOXA10: A Culprit in Endometriosis Disease Progression By Kasthuri Nair

Zheng et al., a group of authors from the Aerospace Center Hospital in Bejing and from the First Affiliated Hospital of Wenzhou Medical University in Wenzhou, recently published a paper in Reproductive Sciences entitled “Decreased Expression of HOXA10 May Activate the…

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The effects of MK2206 and chloroquine combination therapy on endometriosis.

The effects of MK2206 and chloroquine combination therapy on endometriosis. By Dr. Youngran Park

Endometriosis affects approximately 10% of women of reproductive age. A high recurrence rate after medical treatment with or without surgery is a significant clinical problem for patients with endometriosis. Establishment of a complete cure for patients with endometriosis awaits new…

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Autophagy in endometriosis

Autophagy in endometriosis By Dr. Youngran Park

Endometriosis is a common gynecologic disease affecting both fertile (5-10%) and infertile (20-50%) women, and it commonly causes chronic pelvic pain, dysmenorrhea, and infertility. Recent research found that the autophagy exerts a pro-apoptotic effect on normal human endometrial cells and…

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Retinoic Acid and Beclin1 Play an Opposite Role in Endometriosis Development

Retinoic Acid and Beclin1 Play an Opposite Role in Endometriosis Development By Kasthuri Nair

In their paper titled “Retinoic acid regulates endometriotic stromal cell growth through upregulation of Beclin1,” Lu et al. seek to elucidate the mechanism that drives endometriosis disease progression. Retinoic Acid (RA) is a vitamin A metabolite responsible for regulation of…

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Autophagy in endometriosis: Friend or foe?  

Autophagy in endometriosis: Friend or foe?   By Dr. Youngran Park

Endometriosis is a chronic, estrogen-dependent disease and affects an estimated 10% of the female population of reproductive age. Unfortunately, the etiology of endometriosis is not clear. Recently emerging evidence shows that there is a close relationship between endometriosis and autophagy.…

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