Separation of epithelia and stroma components in endometriosis lesions yields remarkable molecular points - Ie-Ming Shih, MD, Ph.D.

Separation of epithelia and stroma components in endometriosis lesions yields remarkable molecular points - Ie-Ming Shih, MD, Ph.D. By Nasuhi Engin Aydin

The pathologies of adenomyosis and endometriosis are unique among non-malignant gynecological diseases and provide fertile research topics. Ectopic endometrial tissues may have distinct molecular changes distinct from eutopic endometria despite having similar morphology. In this regard, there are intriguing suggestions as…

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The Molecular Profile Unique to Endometriosis

The Molecular Profile Unique to Endometriosis By Murat Osman

Endometriosis remains to be a disease entity that is not fully understood. However, recent studies suggest that endometriosis is characterized by several dysregulated biochemical pathways that allow for its survival and growth outside the uterine endometrium. Authors have recently published…

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Additional research in understanding the causative link between Notch signaling and endometriosis

Additional research in understanding the causative link between Notch signaling and endometriosis By Nasuhi Engin Aydin

Dustin M. Brown and associates from the University of Arkansas for Medical Sciences published their unique complex molecular research in the Journal of the Endocrine Society. This study group previously showed that decreased expression of the progesterone receptor (PGR) resulted from…

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Endometriosis in adolescents

Endometriosis in adolescents By Irem Onur

Dr. Mama S. T. from Cooper University Hospital, Camden, New Jersey, USA, recently has published his review on advances in the management of endometriosis in the adolescent in the journal “Current Opinion Obstetrics and Gynecology”. In adolescence, there is a…

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The pathogenesis of endometriosis : New discoveries with clinical impact

 The pathogenesis of endometriosis : New discoveries with clinical impact By Nasuhi Engin Aydin

In this recent review article that appeared in Current Women’s Health Reviews, compiled by researchers from the Department of Molecular Cell Biology and Human Genetics, Institute of Cell Biology and Neuroscience Frankfurt, Germany the following important points in regard to the molecular and cellular pathogenesis of…

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Could the cell surface protein "EWI-2" be the new diagnostic marker for endometriosis?

Could the cell surface protein By Murat Osman

Further Understanding: Researchers from the Reproductive Medicine Center of Wuhan University sought to observe the differential expression of EWI-2, (a cell surface protein and an early activation marker, also known as IGSF8 - Immunoglobulin superfamily member 8) in 145 women…

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Hypoxia induces molecular pathways favoring survival of endometriosis

Hypoxia induces molecular pathways favoring survival of endometriosis By Laura Ardighieri

Kuei-Yang Hsiao and colleagues from the Department of Physiology and the Department of Obstetrics and Gynecology College of Medicine, National Cheng Kung University, Tainan, Taiwan, have investigated the molecular basis of this phenomenon. In particular, they found that hypoxia significantly…

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