By Eylül GÜNNew developments in endometriosis from a molecular and cellular standpoint
By Eylül GÜN
Researchers are making significant progress in endometriosis regarding molecular and cellular research, with collaborative efforts by clinicians, scientists, surgeons, and biostatisticians. Laganà et al. from Italy wrote an editorial regarding the recent special issue called "Molecular and Cellular Advances in Endometriosis Research…
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By Selma OransayA review for genetics of endometriosis.
By Selma Oransay
There is an increased risk of developing endometriosis among first-degree relatives, which can raise suspicions of the role of genetic factors in endometriosis. Genome-wide association studies and next-generation sequencing have identified numerous genetic loci and variants relating to the disease.…
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By Nasuhi Engin AydinEpigenetic defects of stromal cells in endometriosis and adenomyosis lead to estrogen sensitivity
By Nasuhi Engin Aydin
Serdar Bulun, MD, J.J. Sciarra Professor and Chair Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois has delivered a conference on “Endometriosis and adenomyosis: single-cell genome-wide approaches” at the Annual International Medical Conference of the Endometriosis Foundation…
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Molecular and cellular mechanisms of fibrogenesis in endometriosis
By Selma Oransay
Endometriosis lesions are characterized by endometrium-like cell proliferation, invasion, and oxidative stress associated with inflammation and neoangiogenesis. Fibrosis, which occurs due to these events, causes chronic pelvic pain depending on the location and the severity of endometriosis. For the purpose…
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By Özge ÖzkayaResearchers Develop New Mouse Model of Endometriosis
By Özge Özkaya
Researchers from China developed a new mouse model to study endometriosis that could help researchers better understand the molecular mechanisms that lead to the development of endometriosis and develop potential new treatments for the disease. Even though many animal models…
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Fibrosis is not only a histological finding in endometriosis
By Eylül GÜN
Endometriosis remains to be an active subject of research with its complex pathophysiology and the indistinct mechanisms that cause the proliferation and progression of the lesions. Besides the already known characteristics of the disease, there is strong evidence to support…
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Molecular alterations in endometriosis pathogenesis
By Eylül GÜN
Endometriosis has been in our lives for decades, however little is known about its pathogenesis making it hard to diagnose and manage. A review study conducted by Balasubramanian et al. from India reveals all the characteristics and the underlying conditions…
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Etiopathogenesis of Endometriosis and Links with Endometrial Cancer
By Nasuhi Engin Aydin
Professor Terzic and colleagues from the Medical School of Nazarbayev University, Kazakhstan published their review on the molecular aspects of endometriosis and endometrial cancer in “International Journal of Molecular Sciences”. The etiopathogenesis of endometriosis has remained controversial, with recent studies…
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New molecular insights in endometriosis pathogenesis
By Nasuhi Engin Aydin
Dr. Rosalba Siracusa and associates from Messina University, Italy, have published their research on cellular pathogenesis of experimental endometriotic lesions in the recent issue of the "International Journal of Molecular Sciences". Endometriosis is a debilitating chronic estrogen-dependent inflammatory condition and…
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Separation of epithelia and stroma components in endometriosis lesions yields remarkable molecular points - Ie-Ming Shih, MD, Ph.D.
By Nasuhi Engin Aydin
The pathologies of adenomyosis and endometriosis are unique among non-malignant gynecological diseases and provide fertile research topics. Ectopic endometrial tissues may have distinct molecular changes distinct from eutopic endometria despite having similar morphology. In this regard, there are intriguing suggestions as…
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By Murat OsmanThe Molecular Profile Unique to Endometriosis
By Murat Osman
Endometriosis remains to be a disease entity that is not fully understood. However, recent studies suggest that endometriosis is characterized by several dysregulated biochemical pathways that allow for its survival and growth outside the uterine endometrium. Authors have recently published…
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Additional research in understanding the causative link between Notch signaling and endometriosis
By Nasuhi Engin Aydin
Dustin M. Brown and associates from the University of Arkansas for Medical Sciences published their unique complex molecular research in the Journal of the Endocrine Society. This study group previously showed that decreased expression of the progesterone receptor (PGR) resulted from…
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By Irem OnurEndometriosis in adolescents
By Irem Onur
Dr. Mama S. T. from Cooper University Hospital, Camden, New Jersey, USA, recently has published his review on advances in the management of endometriosis in the adolescent in the journal “Current Opinion Obstetrics and Gynecology”. In adolescence, there is a…
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The pathogenesis of endometriosis : New discoveries with clinical impact
By Nasuhi Engin Aydin
In this recent review article that appeared in Current Women’s Health Reviews, compiled by researchers from the Department of Molecular Cell Biology and Human Genetics, Institute of Cell Biology and Neuroscience Frankfurt, Germany the following important points in regard to the molecular and cellular pathogenesis of…
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Could the cell surface protein "EWI-2" be the new diagnostic marker for endometriosis?
By Murat Osman
Further Understanding: Researchers from the Reproductive Medicine Center of Wuhan University sought to observe the differential expression of EWI-2, (a cell surface protein and an early activation marker, also known as IGSF8 - Immunoglobulin superfamily member 8) in 145 women…
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By Laura ArdighieriHypoxia induces molecular pathways favoring survival of endometriosis
By Laura Ardighieri
Kuei-Yang Hsiao and colleagues from the Department of Physiology and the Department of Obstetrics and Gynecology College of Medicine, National Cheng Kung University, Tainan, Taiwan, have investigated the molecular basis of this phenomenon. In particular, they found that hypoxia significantly…
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