Analysis of steroid hormone receptors in endometriotic tissues reveals chaotic results

Analysis of steroid hormone receptors in endometriotic tissues reveals chaotic results By Nasuhi Engin Aydin

  A group of researchers from academic institutions located at Australia and New Zeland, led by Dr. Holdsworth-Carson, have published their recent findings on steroid receptors in peritoneal endometriosis lesions by immunohistochemistry, in the journal Reproduvtive Biomedicine Online.  Endometriosis is…

Key Points Lay Summary

Potential New Approach to Treat Endometriosis

Potential New Approach to Treat Endometriosis By Özge Özkaya

Inhibiting ribosome biogenesis could be a potential therapeutic approach for endometriosis according to a new study published in the scientific journal Biomedicines. Ribosome biogenesis plays a key role in protein homeostasis during cell growth and division. Previous research has shown…

Key Points Lay Summary

Diaphragmatic endometriosis

Diaphragmatic endometriosis By Selma Oransay

Diaphragmatic endometriosis is a rare clinical condition that may show signs and symptoms like chest pain, right upper quadrant abdominal pain, shoulder pain, pleuritic pain, hemothorax, pneumothorax, hemoptysis, and thoracic endometriosis syndrome while the major part of the patients is…

Key Points Lay Summary

Indocyanin Green dye for recognition of occult endometriotic lesions

Indocyanin Green dye for recognition of occult endometriotic lesions By Bahar Yuksel

The surgery for endometriosis is challenging and the resection of all lesions is not accurately related to not catching all lesions under white light (WL) conventional laparoscopy. In the study conducted by Luigi Carlo Turco et al., in a tertiary…

Key Points Lay Summary

Complex Relation Between Body mass index and endometriosis

Complex Relation Between Body mass index and endometriosis By Selma Oransay

This research aimed to find the relationship between BMI and endometriosis especially related to surgical phenotype and lesion location. An observational cohort study was led by  Holdsworth-Carson et al, from Australia. The article was recently published in "RBMO" . Many earlier studies report…

Key Points Lay Summary

Targeting Endometriosis From a Different Angle

Targeting Endometriosis From a Different Angle By Özge Özkaya

Dopamine agonists could help reduce the size of endometriosis lesions and minimize pain, while maintaining ovulation, according to a new study published in the scientific journal Human Reproduction. This constitutes a completely different approach in targeting endometriosis according to Dr.…

Key Points Lay Summary

Cabergoline or Progesterone not Effective in Rat Model of Endometriosis

Cabergoline or Progesterone not Effective in Rat Model of Endometriosis By Özge Özkaya

Oral treatment with cabergoline or micronized progesterone for four weeks is not effective in the regression of endometriotic implants in a rat model of the disease. This is according to a study published in the "Journal of Investigative Surgery".  Cabergoline…

Key Points Lay Summary

Transvaginal sonography for predicting the distance between rectosigmoid endometriosis and the anal verge

Transvaginal sonography for predicting the distance between rectosigmoid endometriosis and the anal verge By Timur Seckin

For optimal surgery, pre-surgical assessment of the distance between rectosigmoid deep endometriosis lesions and the anal verge (Lesion to Anal Verge Distance-LAVD) is recommended by many specialists. A group of researchers from Norway, Austria, and Australia studied the accuracy of…

Key Points Lay Summary

IL-33 Polarize Peritoneal Macrophages for Endometriosis Growth

IL-33 Polarize Peritoneal Macrophages for Endometriosis Growth By Nadire Duru

M2 type macrophages are the most common type of macrophages found in endometriosis and they enhance the development of endometriosis lesions. The key factors that stimulate macrophages to polarize towards M2 and contribute to the increased endometriosis lesions remain to be…

Key Points Lay Summary

Does Getting Pregnant Really Help When You Have Endometriosis?

Does Getting Pregnant Really Help When You Have Endometriosis? By Özge Özkaya

Pregnancy has a favorable impact on the volume of deep infiltrating endometriosis lesions according to a study published in the scientific journal "PLoS One". This is the first study that demonstrates such a favorable impact of pregnancy on endometriosis lesion…

Key Points Lay Summary

Which cell defines endometriosis?

Which cell defines endometriosis? By Murat Osman

A well-accepted theory regarding the pathogenesis of endometriosis hypothesizes that the origin of endometriosis is from peritoneal dissemination of endometrial cells and stroma during the neonatal period or menarche. Varying cellular components of endometriosis have been observed in the setting…

Key Points Lay Summary

Ultrasound-guided High-intensity Focused Ultrasound can Treat Abdominal Wall Endometriosis

Ultrasound-guided High-intensity Focused Ultrasound can Treat Abdominal Wall Endometriosis By Kasthuri Nair

Endometriosis is a painful and complicated disease that can manifest in various ways. One particular way is Abdominal Wall Endometriosis (AWE), which usually arises from surgery. As is true for other types of endometriosis, there has yet to be a…

Key Points Lay Summary

Detection of Uterine Malformations and its Link to Endometriosis

Detection of Uterine Malformations and its Link to Endometriosis By Kasthuri Nair

Dr. Abd El Fattah recently published a research article titled “Uterine Cavity Abnormalities in Patients with Endometriosis in Alexandria: A Diagnostic Test Accuracy Study” in Obstetrics and Gynecology International that delineated and presented the results of his study. The study has two…

Key Points Lay Summary

Combination Therapy Proves More Efficient in the Treatment of Endometriosis

Combination Therapy Proves More Efficient in the Treatment of Endometriosis By Kasthuri Nair

In their recent paper in British Journal of Pharmacology, entitled “Combination therapy with telmisartan and parecoxib induces regression of endometriotic lesions,” Nenicu et al. illustrate the increased effectiveness of telmisartan used along with a cyclooxygenase-2 (COX-2) inhibitor (a non-steroidal anti-inflammatory…

Key Points Lay Summary