By Ayse AyhanThe Endometriosis–Brain Connection
By Ayse Ayhan
A study published in Communications Biology (Nature Portfolio), the teaam led by Dr. Scott Holmes at Boston Children’s Hospital and Harvard Medical School, explored whether long-standing endometriosis-associated pain is linked to differences in brain structure, and whether these patterns vary with age. The researchers…
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By Selma OransayLaparoscopic Pudendal Neurolysis: A Solution for Entrapment-Related Pelvic Pain
By Selma Oransay
Pudendal neuralgia is a debilitating condition marked by chronic neuropathic pain in areas innervated by the pudendal nerve, often worsening with sitting and accompanied by urinary, bowel, and sexual dysfunctions. Central sensitization—a heightened nervous system reactivity—affects nearly half of these…
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Linking Endometriosis to Age-Related Macular Degeneration
By Selma Oransay
The macula, the central region of the retina, is crucial for sharp central vision and the color perception. Age-related macular degeneration (AMD) primarily affects this area and progresses through different stages, ranging from early to advanced forms. AMD has two…
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By Eylül GÜNGenetic Insights into Brain Networks and Their Impact on Endometriosis Risk
By Eylül GÜN
While the exact origins of endometriosis are still not fully understood, emerging evidence points to the central nervous system (CNS) as a significant factor in the development and persistence of the condition. The CNS is responsible for processing pain signals,…
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Diaphragma central tendon and catamenial pneumothorax
By Selma Oransay
Endometriosis typically involves ectopic endometrial tissue in pelvic organs, such as the bladder, ovaries, and uterine ligaments, leading to symptoms like dysmenorrhea, dyspareunia, and dyschezia. A rare form occurs in the diaphragm, causing catamenial pneumothorax. Management often includes hormone therapy…
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Exploring the underlying causes of orgasm-related pain in endometriosis
By Eylül GÜN
As one of the most common symptoms of endometriosis, pain may involve peripheral or central mechanisms resulting in different pain sensations. Female orgasm pain is an underexplored condition associated with pelvic floor myalgia and uterine factors like adenomyosis, likely due to…
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An often overlooked symptom: Sleep disorders in patients with endometriosis
By Selma Oransay
Recent reports suggested that women with endometriosis have more frequent complaints of poor sleep, reduced quality of life, and higher pain scores when compared with healthy women. Patients experience fatigue and increased pain the day after insomnia. For this reason,…
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By Hale Goksever CelikThe effect of medical treatment on sexual function and quality of life in women with endometriosis
By Hale Goksever Celik
Women with endometriosis suffer from dysmenorrhea, dyspareunia and chronic pelvic pain, all of which has significant negative consequences on their physical and psychological health regarding sexual function, work and social relationships. Biasioli et al. from Italy, published an article entitled…
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By Özge ÖzkayaObjective Assessment of Pain Sensitization in Women With Chronic Pelvic Pain
By Özge Özkaya
There are objective elements that can help assess the presence of central sensitization, independently of psychological factors, according to a new study published in the American Journal of Obstetrics and Gynecology. This is the first study that assessed whether central sensitization…
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The role of neurogenic inflammation in endometriosis
By Eylül GÜN
Prof. Mechsner from Charité—Universitätsmedizin Berlin, Germany presented on neuroimmunomodulation and its clinical impact on endometriosis at the Annual International Medical Conference of the Endometriosis Foundation of America. Endometriosis is a complex disease and the main symptoms are all pain-related. The pain mechanisms are…
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Endometriosis and the possible mechanisms of pain.
By Selma Oransay
The most common clinical symptoms of endometriosis are chronic pelvic pain and infertility. It is often not enough to treat pain symptoms with hormonal therapy or a surgical approach. Moreover, the stage of endometriosis has weakly associated with the amount,…
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Chronic pelvic pain and endometriosis
By Selma Oransay
Patients may have an average of 7 clinical visits before being diagnosed with endometriosis. Understanding chronic pain conditions including endometriosis-associated pain, and developing chronic pelvic pain benefits the management of the patients. The role of central sensitization, comorbid conditions, and…
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Persistence of Chronic Pelvic Pain after Hysterectomy
By Hale Goksever Celik
Chronic pelvic pain is defined as the "pain in the pelvic area that lasts for 6 months or longer". There are several gynecological, urological, and gastrointestinal reasons for the development of chronic pelvic pain. Nociceptive pain or central sensitization is…
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By Nasuhi Engin AydinThe clues for pain and infertility in endometriosis/adenomyosis complex
By Nasuhi Engin Aydin
Drs. Gruber and Mechsner from Charite University-Berlin, Germany published their comprehensive review on pathophysiological background of endometriosis and adenomyosis in the scientific periodical “Cells”. Chronic pain and fertility problems are the main clinical issue in endometriosis and adenomyosis patients. In order to…
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Women with Persistent Pelvic Pain Have a Lower Pain Threshold
By Özge Özkaya
Women with persistent pelvic pain, whether this is caused by endometriosis or other reason, have a significantly reduced pain threshold compared to women without persistent pelvic pain. This is according to a study by researchers in Sweden, which was published…
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Pain Education or Cognitive Therapy Could Help Women with Endometriosis
By Özge Özkaya
Women with endometriosis have a significantly lower pain tolerance regardless of the intensity of the pain they experience or the severity of their disease, according to a study published in the scientific journal Fertility and Sterility. Although pain is the…
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