Cells Constituting Endometriosis Have Different Properties

Cells Constituting Endometriosis Have Different Properties By Özge Özkaya

Many cell types are altered in endometriosis, found a new study published in the Journal of Pathology. The study also found that depending on the subtype of endometriosis, endometriosis cells show signatures of estrogen responsiveness, immunologic cytotoxicity, and proinflammation. Finally, it identified…

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Preclinical organ-on-chip models of endometriosis lesions - Linda Griffith, PhD

Preclinical organ-on-chip models of endometriosis lesions - Linda Griffith, PhD By Özge Özkaya

Professor Linda Griffith, Professor of Biological and Mechanical Engineering and the director of the Center for Gynepathology Research at Massachusetts Institute of Technology gave a presentation about their preclinical organ on-chip models of endometriosis lesions at the 14th Annual International…

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Matrix metalloproteinases and their role in endometriosis

Matrix metalloproteinases and their role in endometriosis By Eylül GÜN

The extracellular matrix harbors important macromolecules such as collagen and glycoproteins which are required for tissue remodeling, differentiation, and homeostasis. The main group of enzymes responsible for these properties is called matrix metalloproteinases (MMPs). It has been proven that MMPs…

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Inflammatory and genetical background of endometriosis may yield new therapeutic approaches

Inflammatory and genetical background of endometriosis may yield new therapeutic approaches By Nasuhi Engin Aydin

Elisa Giacomini and colleagues from medical centers in Milan, Italy have published their review manuscript on the inflammatory and genetical pathogenetic background of endometriosis in a recent issue of  “International Journal of Molecular Sciences”, suggesting also new therapeutic approaches. The inflammatory…

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Menstrual Blood Proteins for Endometriosis Diagnosis

Menstrual Blood Proteins for Endometriosis Diagnosis By Ellen Tumimbang

Endometriosis is a gynecological disorder characterized by endometrial tissue outside the uterine cavity. The backflow of menstrual blood from the uterus through the fallopian tubes is thought to be the cause of endometrial tissue growing outside the uterine cavity when…

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Study Sheds Light on Physiological Processes Associated with Endometriosis

Study Sheds Light on Physiological Processes Associated with Endometriosis By Özge Özkaya

Sensory nerves play an important role in the development of endometriosis as well as fibrosis, confirms a study by Chinese researchers.  A better understanding of physiological processes associated with the development of endometriosis can help researchers devise new ways to…

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Menstrual blood-derived stem cells

Menstrual blood-derived stem cells By Selma Oransay

Chen et al.  from the Center of Diagnosis and Treatment of İnfectious Disease, Zhejiang University, China penned this recent review in the Journal of Stem Cell Research Therapy which is presenting the clinical potential of MenSCs (Menstrual blood-derived stem cells). …

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Exosome: a new avenue for endometriosis research

Exosome: a new avenue for endometriosis research By Dr. Youngran Park

Endometriosis affects 10% of reproductive-aged women. The pathophysiology of this disease remains mysterious, with a lack of effective biomarkers necessitating surgical intervention for diagnosis. This creates an urgent need for accurate noninvasive diagnostic tests and the identification of effective therapeutic…

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A Balancing Act: How Endometriosis Invades the Body

A Balancing Act: How Endometriosis Invades the Body By Murat Osman

Endometriosis is a disease defined by the presence of endometrial tissue outside of the uterine cavity. Ectopic endometrial tissues have been shown to have some features that mimic malignancy. For example, endometriosis can invade surrounding structures and attach to surfaces such…

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Is there a new hope for the prevention of endometriotic invasions?

Is there a new hope for the prevention of endometriotic invasions? By Selma Oransay

This research which recently published in Biomed Research International is performed by Xiaomei et al. from Obst/Gyn, Pathology and Genetic departments of three hospitals in Changsha, CHINA. The authors planned a prospective and controlled biochemical study to specify the role…

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The pathogenesis of endometriosis : New discoveries with clinical impact

 The pathogenesis of endometriosis : New discoveries with clinical impact By Nasuhi Engin Aydin

In this recent review article that appeared in Current Women’s Health Reviews, compiled by researchers from the Department of Molecular Cell Biology and Human Genetics, Institute of Cell Biology and Neuroscience Frankfurt, Germany the following important points in regard to the molecular and cellular pathogenesis of…

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A Potential New Target for the Treatment of Endometriosis

A Potential New Target for the Treatment of Endometriosis By Özge Özkaya

A protein called STIP1 could be facilitating the migration of endometrial tissue outside the uterus, therefore, leading to endometriosis according to a study by Taiwanese researchers. The protein could, thus, be used as a potential therapeutic target for endometriosis.  For…

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Ectoenzymes as endometriosis biomarkers

Ectoenzymes as endometriosis biomarkers By Yu Yu

The diagnosis of endometriosis is often delayed by 7 to 11 years because of the lack of a non-invasive diagnostic test. The ovarian endometriomas occur in about 17%-44% of women with endometriosis and cysts which contain endometrial tissue and fluid…

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