Endometriosis and nuclear receptors

Endometriosis and nuclear receptors By Dr. Youngran Park

It is well recognized that endometriosis is a steroid-dependent disorder. In endometrial stromal cells, progesterone regulates retinoic acid production and action. Retinoids also act via a number of nuclear receptors (NRs) and are involved in normal endometrial function and endometriosis. Estrogen…

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Menstrual blood-derived stem cells

Menstrual blood-derived stem cells By Selma Oransay

Chen et al.  from the Center of Diagnosis and Treatment of İnfectious Disease, Zhejiang University, China penned this recent review in the Journal of Stem Cell Research Therapy which is presenting the clinical potential of MenSCs (Menstrual blood-derived stem cells). …

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Is the mystery for progression of endometriosis hiding out in abnormally located endometrial cells?

Is the mystery for  progression of endometriosis hiding out in abnormally located endometrial cells? By Selma Oransay

This prospective study was conducted by Hapangama et al. in Research İnstute of the University of Liverpool, UK, and the results have recently published in the Journal of Human Reproduction. The authors hypothesized that abnormally located endometrial basalis-like (SSEA1/nSOX9+)cells could be contributing to…

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Endometriosis Development: Pathogenesis and genomics

Endometriosis Development: Pathogenesis and genomics By Selma Oransay

In this review recently published in the International Journal of Molecular Sciences, Baranow et al from Saint Petersburg, Russia,  hypothesize the existence of an endometriosis development genetic program (EMDP) that governs the origin of endometrium stem cells programmed for endometriosis; their transition…

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Therapeutic strategies involving uterine stem cells in reproductive medicine

Therapeutic strategies involving uterine stem cells in reproductive medicine By Murat Osman

Stem cells are undifferentiated cells that often serve to regenerate tissue in states of injury or apoptosis. The endometrium has progenitor cells that replace tissue lost after each menstrual cycle. It has been postulated that excessive stem cell recruitment to…

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Mechanism for Migration of Endometriosis Cells in the Body

Mechanism for Migration of Endometriosis Cells in the Body By Kasthuri Nair

Li et al. recently published a paper in Stem Cells titled “Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis.” This article seeks to understand the mechanisms underlying the migration of endometriosis. The authors initially hypothesize that endometriosis-derived mesenchymal stem cells…

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Endometrial stem cells and Endometriosis

Endometrial stem cells and Endometriosis By Dr. Youngran Park

Human endometrium is a cyclically proliferative tissue, and this monthly regeneration is likely mediated by endometrial stem (or progenitor) cells.The upper functional layer of the endometrium breaks down and is shed into the uterine cavity during menstruation. Re-epithelialization and repair…

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The endometrial stem cell markers notch-1 and numb are associated with endometriosis. 

The endometrial stem cell markers notch-1 and numb are associated with endometriosis.  By Dr. Youngran Park

The pathological mechanisms of endometriosis are still poorly understood. However, stem cells have been candidates of interest because of their high proliferation potential and their ability to differentiate into multiple lineages, contributing to characteristic traits of endometriosis. Also, previous studies…

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EFA Medical Conference 2017: "Cells Are the New Cure" Presentation by Dr. Max Gomez

EFA Medical Conference 2017: By Kasthuri Nair

Dr. Max Gomez is an award-winning broadcast journalist, CBS News Medical Correspondent, and a presenter at the EFA 2017 Medical Conference. Dr. Gomez’s presentation was titled “Cells Are the New Cure: The Cutting-Edge Medical Breakthroughs That Are Transforming Our Health.”…

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Human Endometrium-Derived Mesenchymal Stem Cells for Cell-based Therapies

Human Endometrium-Derived Mesenchymal Stem Cells for Cell-based Therapies By Yu Yu

Mesenchymal stem cells are a promising candidate for cell-based targeted therapies because they have characteristics such as self-renewal, multipotency, low immunogenicity, and non-oncogenicity. It has the capacity to migrate to sites of inflammation including in endometrial lesions and tumor. Most…

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Endometriosis : A Whole Body Disease

Endometriosis : A Whole Body Disease By Kasthuri Nair

Endometriosis is a disease that impacts multiple parts of an individual’s body. Seminars in Reproductive Medicine recently published a paper by Alderman III et al. entitled “The Systemic Effects of Endometriosis” explores the various comorbidities that can affect individuals suffering…

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