By Eylül GÜNWhy is there a higher risk of stroke for women with endometriosis?
By Eylül GÜN
Women diagnosed with endometriosis might face an increased susceptibility to stroke due to alterations in the levels of some molecules in their systems. Studies indicate that especially those undergoing hysterectomy/oophorectomy, have an approximately 30% higher risk of stroke. Dr. Mormile…
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By Nasuhi Engin AydinA herbal product has promising results in experimental endometriosis
By Nasuhi Engin Aydin
Neroli oil (bitter orange) is a nontoxic volatile substance from the flowers of Citrus aurantium that belongs to the Rutaceae family. This oil has notable anti-inflammatory effects besides potent antioxidant activity with 100% singlet oxygen scavenging activity. Contemporary pathophysiological views…
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Alterations of mitochondrial dynamics in endometriosis
By Eylül GÜN
Mitochondria are known as the batteries of the cell with the ATP that they produce through oxidative phosphorylation. Mitochondrial dynamics are important mechanisms for mitochondria to maintain their integrity by continuously undergoing changes. Mitochondrial fusion is the joining of two…
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By Selma OransayIs continuous hormonal treatment safe and healthy method for endometriotic patients?
By Selma Oransay
One of the studies related to the search for new markers in pathophysiologic causes of endometriosis is circulating microparticles and their subset "tissue factor". In response to damage, activation, or apoptosis, these microparticles are found in human plasma, urine, saliva,…
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By Hale Goksever CelikThe effect of dienogest vs ethynyl estradiol/dienogest on quality of life in women with endometriosis
By Hale Goksever Celik
Women with endometriosis suffer from dysmenorrhea, dyspareunia, and chronic pelvic pain that diminishes the quality of their life. Both physical and mental components of quality of life have been affected by endometriosis-associated symptoms. There are several medical and surgical treatment…
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Endometriosis Hospitalization Trends in Spain
By Eylül GÜN
According to the general assumption, one in every ten women is believed to have endometriosis. However, recent literature shows a big difference in the prevalence rates ranging from 1 to 5%, likely because most cases remain undiagnosed. The need for…
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The necessity of laparoscopy for unexplained infertility.
By Selma Oransay
The standard for accepting a couple as "infertile" is the inability to conceive after 12 months of regular unprotected intercourse. When this condition is met, assessing the number of motile sperm in the male partner and certifying the patency at…
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Endometriosis, ART, fertility preservation
By Selma Oransay
This review entitled "The impact of endometriosis on the outcome of assisted reproductive techniques: role of fertility preservation" was written by Necula et al. from Gynecology and Obstetrics Unit, Biel, Switzerland, and recently published in the journal "Hormone, Molecular Biology and Clinical…
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"Speckle sign": a novel transvaginal ultrasound finding for posterior compartment endometriosis
By Nasuhi Engin Aydin
Dr. Balcacer and associates from three medical institutions located in the USA report the results of their retrospective study on deep infiltrating endometriosis utilizing transvaginal ultrasound examination and the proposed “speckle sign” in the "Journal of Ultrasound Medicine". Pelvic ultrasound…
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By Dr. Youngran ParkImmune cells and endometriosis pain
By Dr. Youngran Park
Endometriosis is an estrogen-dependent inflammatory disorder in women. This disease leads to dysmenorrhea, pelvic pain, and infertility. The immune reaction is one of the most widely accepted pathologies of endometriosis. Estrogen dysfunction stimulates immune cells in the peritoneal cavity affecting…
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By Özge ÖzkayaA New Treatment Approach for Endometriosis?
By Özge Özkaya
A new approach may be effective at relieving pain associated with endometriosis according to a study published in the PM&R Journal. The new technique may also improve “overall pelvic function, particularly in relation to intercourse, working, and sleeping,” according to the…
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Fertility conservation in women with endometriosis
By Selma Oransay
Endometriosis affects 10-15% of women in their reproductive period and almost half of them may need Assisted Reproductive techniques to conceive. Moreover, increased malignancy risk is threatening the women with severe endometriosis in addition to their decreased ovarian reserve. Due…
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By Irem OnurKisspeptin and its Receptor in the Pathogenesis of Endometriosis
By Irem Onur
It is known that matrix metalloproteinases (MMP) may play a role in the pathogenesis of endometriosis. For example, the upregulation of MMP-2 and MMP-9 may enhance the degradation of extracellular matrix proteins, facilitating cell migration and invasion. Kisspeptin (KISS1, also…
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Preoperative serum CA 125 levels predict the severity of adhesions in endometriosis
By Irem Onur
Lee Y. et al., a group of researchers from Korea evaluated the correlation between preoperative serum markers and pelvic adhesions in endometriosis patients and explored the markers’ clinical value for outcome prediction. They have recently published their study in the…
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By Yu YuA miniaturized version of endometrium: organoids for endometriosis research
By Yu Yu
Organoids are a miniaturized version of a tissue that is produced in culture through three dimensions techniques in order to better mimic the tissues of origin. These cultures are supposed to better replicate the complexity of a biological organ/disease. Endometrial…
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Non‑invasive biomarkers for endometriosis diagnosis
By Hale Goksever Celik
Endometriosis is a disease of women in reproductive age and its incidence varies between 5-10%. Since the diagnosis is based on the histological confirmation, there is an average of 7 to 11 years of delays in the diagnosis. Promising non-invasive…
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The reason for lower BMI and less body fat in women with endometriosis.
By Selma Oransay
Zolbin et al. from the Department of Obstetrics and Gynecology of Yale School of Medicine, New Haven, USA, recently published the results of their prospective controlled research on adipocyte alterations in endometriosis, in the journal "Reproductive Biology and Endocrinology". Endometriosis can…
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Conservative Surgery May Be Sufficient to Halt the Development of Deep Endometriosis
By Özge Özkaya
Deep endometriosis develops as a result of collective cell migration and nerve recruitment from surrounding organs, suggests a study published in the scientific journal Fertility and Sterility. Collective cell migration is the biological process whereby a group of cells moves…
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Drugs targeting estrogen biosynthesis opening up new approaches to the treatment of endometriosis.
By Selma Oransay
Gibson et al., from the Univerity of Edinburgh, UK, take over a new interest about endometriosis occurrence and progress by endometrial tissue intracrinology in their recently online published article in International Journal of Molecular Sciences. The authors summarize the last…
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FDA Approves Endometriosis Pain Treatment
By Özge Özkaya
The U.S. Food and Drug Administration (FDA) approved a new medication for the treatment of moderate to severe pain associated with endometriosis, making it the first treatment to be approved in 10 years. The decision was announced in the Journal…
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Will my Endometriosis Respond to Hormone Therapy?
By Özge Özkaya
Every woman has a different set of hormone receptors in the lining of their uterus. Yet, hormone-based therapies that are used to treat women with endometriosis do not take into consideration these differences among patients. Analyzing, which particular hormone receptors…
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Non-coding RNAs in endometriosis
By Dr. Youngran Park
The pathophysiological mechanisms causing the development of endometriosis, which is a heterogeneous disease remain enigmatic, and a lack of effective biomarkers necessitates surgical intervention for diagnosis. Non-coding RNA (ncRNA) molecules, which are important regulators of cellular function, have been implicated…
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By Kasthuri NairHOXA10: A Culprit in Endometriosis Disease Progression
By Kasthuri Nair
Zheng et al., a group of authors from the Aerospace Center Hospital in Bejing and from the First Affiliated Hospital of Wenzhou Medical University in Wenzhou, recently published a paper in Reproductive Sciences entitled “Decreased Expression of HOXA10 May Activate the…
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EFA Medical Conference 2017: "Breast Cancer in Young Women; Early Diagnosis Timely Intervention" Presentation by Dr. Stephanie Bernik
By Kasthuri Nair
Dr. Stephanie Bernik is the Chief of Surgical Oncology of Surgery and General Surgery at the Lenox Hill Hospital. She recently presented at the EFA 2017 Medical Conference, and her presentation was titled “Breast Cancer in Young Women; Early Diagnosis…
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EFA Medical Conference 2017: "Endometriosis: hormonal or surgical? My reality!" Presentation by Dr. Harry Reich
By Kasthuri Nair
Dr. Harry Reich, the Former Director of Advanced Laparoscopic Surgery at Columbia University Department of OBGYN, was the last speaker in the Mission and History part of the EFA 2017 Medical Conference. His presentation was titled “Endometriosis: hormonal or surgical?…
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Reducing side effect of estrogen based therapy by using Tissue-Selective Estrogen Complex
By Yu Yu
The aberrant regulation of the ERα level in endometriosis and other estrogen-related diseases makes it a promising target for therapy. However, the standard beneficial roles of estrogen in specific target tissues, e.g., the bone, can be primarily affected by such…
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EFA Medical Conference 2017: "The Environmental Risks of Breast Cancer" Presentation by Dr. Marisa Weiss
By Kasthuri Nair
The second speaker in the subsection of the conference titled “Estrogen from Inflammation to Cancer: A Distant Link?” was Dr. Marisa Weiss and she gave a presentation titled “The Environmental Risks of Breast Cancer: Common Ground with Endometriosis.” Dr. Weiss…
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