The role of IL-33 and "T-regs" in lesion progression and fibrosis in endometriosis

The role of IL-33 and By Eylül GÜN

It has been recognized that immune regulation likely plays a crucial role in endometriosis. Regulatory T cells (Tregs) are important immune regulators, and studies have linked Tregs to endometriosis development through signaling pathways involving TGF-β1 and PDGF. IL-33, an inflammatory…

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Fibrosis is not only a histological finding in endometriosis

Fibrosis is not only a histological finding in endometriosis By Eylül GÜN

Endometriosis remains to be an active subject of research with its complex pathophysiology and the indistinct mechanisms that cause the proliferation and progression of the lesions. Besides the already known characteristics of the disease, there is strong evidence to support…

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Endometrioma and its relation with fibrosis, dysmenorrhea, and AMH levels.

Endometrioma and its relation with fibrosis, dysmenorrhea, and AMH levels. By Bahar Yuksel

Endometrioma is an indicator of endometriosis which makes it easy to diagnose the disease for most clinicians. But the symptoms and relationship of endometrioma with menstrual pain severity and the ovarian reserve as well as its markers are not well…

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The cause of PAIN in patients with adenomyosis

The cause of PAIN in patients with adenomyosis By Bahar Yuksel

Adenomyosis is known to be a painful disease with heavy menstrual cycles and negatively affects fertility. Even adenomyosis and endometriosis look alike, it is still crucial to call them as different variation of the same disease. The mechanism underlying the…

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Exploring Pelvic Pain: Deep to Ischial Spine Including Pre-Sacral Roots - A. Taner Usta, MD

Exploring Pelvic Pain: Deep to Ischial Spine Including Pre-Sacral Roots - A. Taner Usta, MD By Irem Onur

Chronic pelvic pain is defined as pain in the pelvic area that lasts for 6 months or longer and results in functional or psychological disability or requires intervention and treatment by the American College of Obstetrics and Gynecologists. There are…

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Inside to outside or from outside to inside?

Inside to outside or from outside to inside? By Nasuhi Engin Aydin

Pathogenesis of "adenomyosis", presence of the ectopic endometrium tissue within the uterine muscles, has largely been classically based on origin from basalis endometrium. Khan and associates from Japan have published their new conceptual findings on adenomyosis in Reproductive BioMedicine Online. In…

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Endometriosis in adolescents

Endometriosis in adolescents By Irem Onur

Dr. Mama S. T. from Cooper University Hospital, Camden, New Jersey, USA, recently has published his review on advances in the management of endometriosis in the adolescent in the journal “Current Opinion Obstetrics and Gynecology”. In adolescence, there is a…

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New Target for Endometriosis Treatment?

New Target for Endometriosis Treatment? By Özge Özkaya

NR4A1 could be a novel target for the treatment of endometriosis, according to a study published in the scientific journal Cell Physiology and Biochemistry. NR4A1 is a receptor protein involved in cell division, inflammation, and programmed cell death. The development…

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Exosomal miR-214 from endometrial stromal cells inhibits endometriosis fibrosis.

Exosomal miR-214 from endometrial stromal cells inhibits endometriosis fibrosis. By Dr. Youngran Park

Fibrosis is an important pathological feature of endometriosis. Novel therapies targeting the mechanisms of fibrosis in endometriosis are indispensable for the development of strategies to prevent and treat endometriosis. Previous microarray studies have detected some miRNAs that are aberrantly expressed…

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Endometriosis and its pro-fibrotic nature. 

Endometriosis and its pro-fibrotic nature.  By Dr. Youngran Park

Endometriosis is currently defined as the presence of endometrial epithelial and stromal cells at ectopic sites. However, with advances in disease knowledge, several vital issues challenge this old definition. Especially, endometrial stromal and glands have been shown to represent only…

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Which cell defines endometriosis?

Which cell defines endometriosis? By Murat Osman

A well-accepted theory regarding the pathogenesis of endometriosis hypothesizes that the origin of endometriosis is from peritoneal dissemination of endometrial cells and stroma during the neonatal period or menarche. Varying cellular components of endometriosis have been observed in the setting…

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Characteristics of Ovarian Endometriotic Cysts Could Help Determine Whether Endometrioma Will Reoccur

Characteristics of Ovarian Endometriotic Cysts Could Help Determine Whether Endometrioma Will Reoccur By Özge Özkaya

The features of ovarian endometriotic cysts could help predict whether endometrioma will re-occur in individual patients, according to a study published in the European Journal of Obstetrics and Gynecology. Predicting the risk of recurrence is important because it can help…

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